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Diffusion tract imaging

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https://www.readbyqxmd.com/read/29453442/white-matter-integrity-in-medication-free-women-with-peripartum-depression-a-tract-based-spatial-statistics-study
#1
Michelle Silver, Constance M Moore, Vanessa Villamarin, Nina Jaitly, Janet E Hall, Anthony J Rothschild, Kristina M Deligiannidis
Diffusion tensor imaging (DTI) studies in depression show decreased structural connectivity in the left anterior limb of the internal capsule and the genu of the corpus callosum but no such studies exist in peripartum depression (PPD), which affects 1 in 8 women. We analyzed fractional anisotropy (FA) as a measure of white matter integrity of these two tracts using tract-based spatial statistics (TBSS). We then conducted an exploratory whole-brain analysis to identify additional regions implicated in PPD. Seventy-five pregnant, medication-free women were evaluated with the Edinburgh Postnatal Depression Scale (EPDS) and Structured Clinical Interview (SCID) for DSM-IV-TR in pregnancy and in the postpartum...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29453439/working-memory-and-brain-tissue-microstructure-white-matter-tract-integrity-based-on-multi-shell-diffusion-mri
#2
Sohae Chung, Els Fieremans, Nuri E Kucukboyaci, Xiuyuan Wang, Charles J Morton, Dmitry S Novikov, Joseph F Rath, Yvonne W Lui
Working memory is a complex cognitive process at the intersection of sensory processing, learning, and short-term memory and also has a general executive attention component. Impaired working memory is associated with a range of neurological and psychiatric disorders, but very little is known about how working memory relates to underlying white matter (WM) microstructure. In this study, we investigate the association between WM microstructure and performance on working memory tasks in healthy adults (right-handed, native English speakers)...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453244/white-matter-change-with-apathy-and-impulsivity-in-frontotemporal-lobar-degeneration-syndromes
#3
Claire J Lansdall, Ian T S Coyle-Gilchrist, P Simon Jones, Patricia Vázquez Rodríguez, Alicia Wilcox, Eileen Wehmann, Katrina M Dick, Trevor W Robbins, James B Rowe
OBJECTIVE: To identify the white matter correlates of apathy and impulsivity in the major syndromes associated with frontotemporal lobar degeneration, using diffusion-weighted imaging and data from the PiPPIN (Pick's Disease and Progressive Supranuclear Palsy: Prevalence and Incidence) study. We included behavioral and language variants of frontotemporal dementia, corticobasal syndrome, and progressive supranuclear palsy. METHODS: Seventy patients and 30 controls underwent diffusion tensor imaging at 3-tesla after detailed assessment of apathy and impulsivity...
February 16, 2018: Neurology
https://www.readbyqxmd.com/read/29450711/renal-fat-fraction-and-diffusion-tensor-imaging-in-patients-with-early-stage-diabetic-nephropathy
#4
Yuan-Cheng Wang, Yinglian Feng, Chun-Qiang Lu, Shenghong Ju
OBJECTIVE: To investigate the renal fat fraction and water molecular diffusion features in patients with early-stage DN using Dixon imaging and diffusion tensor imaging (DTI). METHODS: Sixty-one type 2 diabetics (normoalbuminuria: n = 40; microalbuminuria: n = 21) and 34 non-diabetic volunteers were included. All participants received three-point Dixon imaging and DTI using a 3.0-T magnetic resonance imager. The fat fraction [FF] and DTI features [fractional anisotropy (FA), apparent diffusion coefficient (ADC), tract counts and length from DTI tractography] were collected...
February 15, 2018: European Radiology
https://www.readbyqxmd.com/read/29450539/retinothalamic-white-matter-abnormalities-in-amblyopia
#5
Brian Allen, Melanie A Schmitt, Burton J Kushner, Bas Rokers
Purpose: Amblyopia is associated with a broad array of perceptual and neural abnormalities in the visual system, particularly in untreated or unsuccessfully treated populations. Traditionally, it has been believed that the neural abnormalities are confined to the visual cortex and subcortex (e.g., lateral geniculate nucleus). Here, we investigate the presence of neuroanatomical abnormalities earlier in the visual stream, in the optic nerves and tracts, of participants with two predominant forms of amblyopia...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29449909/alterations-in-the-inferior-longitudinal-fasciculus-in-autism-and-associations-with-visual-processing-a-diffusion-weighted-mri-study
#6
Bart Boets, Lien Van Eylen, Kevin Sitek, Pieter Moors, Ilse Noens, Jean Steyaert, Stefan Sunaert, Johan Wagemans
Background: One of the most reported neural features of autism spectrum disorder (ASD) is the alteration of multiple long-range white matter fiber tracts, as assessed by diffusion-weighted imaging and indexed by reduced fractional anisotropy (FA). Recent methodological advances, however, have shown that this same pattern of reduced FA may be an artifact resulting from excessive head motion and poorer data quality and that aberrant structural connectivity in children with ASD is confined to the right inferior longitudinal fasciculus (ILF)...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29442234/microstructural-changes-in-patients-with-parkinson-disease-and-rem-sleep-behavior-disorder-depressive-symptoms-versus-non-depressed
#7
Farzaneh Ghazi Sherbaf, Farzaneh Rahmani, Sommayeh Mohammadi Jooyandeh, Mohammad Hadi Aarabi
Search for Parkinson's disease (PD) progression biomarkers has led to the identification of both motor and non-motor symptoms relevant of prodromal PD that could be eye-opening to the spreading underlying Lewy body pathogenesis. One most robust predictor of PD is the REM sleep behavior disorder (RBD), and one most common early non-motor symptom of PD is depression. With RBD, frequently coexisting with clinical depression and both predicting dopamine transmission dysfunction, we aimed to survey structural associates of depressive symptoms in early PD patients with comorbid RBD...
February 13, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29440285/nutrient-intake-in-the-first-two-weeks-of-life-and-brain-growth-in-preterm-neonates
#8
Juliane Schneider, Céline J Fischer Fumeaux, Emma G Duerden, Ting Guo, Justin Foong, Myriam Bickle Graz, Patric Hagmann, M Mallar Chakravarty, Petra S Hüppi, Lydie Beauport, Anita C Truttmann, Steven P Miller
BACKGROUND: Optimizing early nutritional intake in preterm neonates may promote brain health and neurodevelopment through enhanced brain maturation. Our objectives were (1) to determine the association of energy and macronutrient intake in the first 2 weeks of life with regional and total brain growth and white matter (WM) maturation, assessed by 3 serial MRI scans in preterm neonates; (2) to examine how critical illness modifies this association; and (3) to investigate the relationship with neurodevelopmental outcomes...
February 13, 2018: Pediatrics
https://www.readbyqxmd.com/read/29433417/clinical-findings-and-neurologic-outcome-in-neonatal-encephalopathy-with-white-matter-injury-accompanied-by-rotavirus
#9
Jae Kyun Ku, Young Jin Heo, Keun Soo Lee, Bo Lyun Lee
Our objective was to elucidate the clinical characteristics and neurodevelopmental outcomes in neonatal encephalopathy with characteristic white matter injury as compared with other injury patterns on magnetic resonance diffusion-weighted imaging. We conducted a retrospective study comparing clinical and laboratory findings, and neurologic outcomes between 17 newborns with diffuse lesions in the periventricular white matter and white matter tract (group I) and 22 newborns with other patterns (group II). Stool samples indicated that 16 neonates (94...
March 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29433118/-trigeminal-herpes-zoster-presenting-with-high-intensity-signals-for-the-spinal-trigeminal-nucleus-and-tract-on-diffusion-weighted-image-a-case-report-of-stroke-mimic
#10
Takahiro Himeno, Shinichi Takeshima, Satoshi Kubo, Naoyuki Hara, Akio Tanaka, Masaru Kuriyama
A 50-year-old woman was admitted to our hospital with dysesthesia on the right upper portion of her face and a headache. Diffusion-weighted brain magnetic resonance imaging (MRI) revealed high-intensity signals in the dorsolateral portion of the medulla oblongata. She was diagnosed with lateral medullary infarction and was intravenously treated with sodium ozagrel. On the second day of hospitalization, she had nausea and vomiting and showed nystagmus to all directions, suggesting damage to the vestibular nucleus...
February 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29427332/genetic-relatedness-of-axial-and-radial-diffusivity-indices-of-cerebral-white-matter-microstructure-in-late-middle-age
#11
Sean N Hatton, Matthew S Panizzon, Eero Vuoksimaa, Donald J Hagler, Christine Fennema-Notestine, Daniel Rinker, Lisa T Eyler, Carol E Franz, Michael J Lyons, Michael C Neale, Ming T Tsuang, Anders M Dale, William S Kremen
Two basic neuroimaging-based characterizations of white matter tracts are the magnitude of water diffusion along the principal tract orientation (axial diffusivity, AD) and water diffusion perpendicular to the principal orientation (radial diffusivity, RD). It is generally accepted that decreases in AD reflect disorganization, damage, or loss of axons, whereas increases in RD are indicative of disruptions to the myelin sheath. Previous reports have detailed the heritability of individual AD and RD measures, but have not examined the extent to which the same or different genetic or environmental factors influence these two phenotypes (except for corpus callosum)...
February 9, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29425267/global-white-matter-diffusion-characteristics-predict-longitudinal-cognitive-change-independently-of-amyloid-status-in-clinically-normal-older-adults
#12
Jennifer S Rabin, Rodrigo D Perea, Rachel F Buckley, Taylor E Neal, Randy L Buckner, Keith A Johnson, Reisa A Sperling, Trey Hedden
White matter degradation has been proposed as one possible explanation for age-related cognitive decline. In the present study, we examined 2 main questions: 1) Do diffusion characteristics predict longitudinal change in cognition independently or synergistically with amyloid status? 2) Are the effects of diffusion characteristics on longitudinal cognitive change tract-specific or global in nature? Cognitive domains of executive function, episodic memory, and processing speed were measured annually (mean follow-up = 3...
February 7, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29423575/normalized-steam-based-diffusion-tensor-imaging-provides-a-robust-assessment-of-muscle-tears-in-football-players-preliminary-results-of-a-new-approach-to-evaluate-muscle-injuries
#13
Chiara Giraudo, Stanislav Motyka, Michael Weber, Manuela Karner, Christoph Resinger, Thorsten Feiweier, Siegfried Trattnig, Wolfgang Bogner
OBJECTIVES: To assess acute muscle tears in professional football players by diffusion tensor imaging (DTI) and evaluate the impact of normalization of data. METHODS: Eight football players with acute lower limb muscle tears were examined. DTI metrics of the injured muscle and corresponding healthy contralateral muscle and of ROIs drawn in muscle tears (ROItear) in the corresponding healthy contralateral muscle (ROIhc_t) in a healthy area ipsilateral to the injury (ROIhi) and in a corresponding contralateral area (ROIhc_i) were compared...
February 8, 2018: European Radiology
https://www.readbyqxmd.com/read/29421348/diffusion-weighted-mri-measures-suggest-increased-white-matter-integrity-in-internet-gaming-disorder-evidence-from-the-comparison-with-recreational-internet-game-users
#14
Guangheng Dong, Lingdan Wu, Ziliang Wang, Yifan Wang, Xiaoxia Du, Marc N Potenza
Several studies have suggested that Internet gaming disorder (IGD) is related to altered brain white matter integrity. However, seeming inconsistencies exist and may reflect comparison groups not matched well for certain gaming characteristics. In order to address this possible concern, we recruited in the present study individuals with recreational Internet game use (RGU) comprised of individuals who spend similar amounts of time as IGD subjects playing online games without developing IGD. Diffusion tensor imaging data were collected from 42 IGD and 44 RGU subjects...
February 2, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29417492/quantitative-susceptibility-mapping-as-a-biomarker-for-evaluating-white-matter-alterations-in-parkinson-s-disease
#15
Xiaojun Guan, Peiyu Huang, Qiaoling Zeng, Chunlei Liu, Hongjiang Wei, Min Xuan, Quanquan Gu, Xiaojun Xu, Nian Wang, Xinfeng Yu, Xiao Luo, Minming Zhang
Myelinated white matter showing diamagnetic susceptibility is important for information transfer in the brain. In Parkinson's disease (PD), the white matter is also suffering degenerative alterations. Quantitative susceptibility mapping (QSM) is a novel technique for noninvasive assessment of regional white matter ultrastructure, and provides different information of white matter in addition to standard diffusion tensor imaging (DTI). In this study, we used QSM to detect spatial white matter alterations in PD patients (n = 65) and age- and sex-matched normal controls (n = 46)...
February 7, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29414128/the-effects-of-5-httlpr-and-bdnf-val66met-polymorphisms-on-neurostructural-changes-in-major-depressive-disorder
#16
Kyu-Man Han, Sunyoung Choi, Aram Kim, June Kang, Eunsoo Won, Woo-Suk Tae, Yong-Ku Kim, Min-Soo Lee, Byung-Joo Ham
The serotonin-transporter-linked polymorphic region (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have been implicated in the pathophysiology of major depressive disorder (MDD). We aimed to investigate the effects of genetic variants of the 5-HTTLPR and BDNF Val66Met polymorphisms and their interactions with MDD on cortical volume and white matter integrity. Ninety-five patients with MDD and 65 healthy participants aged 20-65 years were recruited. The subjects were genotyped for the 5-HTTLPR and BDNF Val66Met polymorphisms and scanned with T1-weighted and diffusion tensor imaging...
February 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29413143/longitudinal-diffusion-tensor-imaging-study-of-adolescents-and-young-adults-with-bipolar-disorder
#17
Judah Weathers, Elizabeth T C Lippard, Linda Spencer, Brian Pittman, Fei Wang, Hilary P Blumberg
OBJECTIVE: Longitudinal neuroimaging during adolescence/young adulthood, when bipolar disorder (BD) commonly emerges, can help elucidate the neurodevelopmental pathophysiology of BD. Adults with BD have shown reduced structural integrity in the uncinate fasciculus (UF), a white matter (WM) tract providing major connections between the amygdala and ventral prefrontal cortex (vPFC), important in emotion regulation. In this longitudinal diffusion tensor imaging (DTI) study of adolescents/young adults, we hypothesized differences in age- and time-related changes in UF integrity in BD compared to healthy controls (HC)...
February 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29410291/orienting-toward-threat-contributions-of-a-subcortical-pathway-transmitting-retinal-afferents-to-the-amygdala-via-the-superior-colliculus-and-pulvinar
#18
Kristin Koller, Robert D Rafal, Adam Platt, Nicholas D Mitchell
Probabilistic diffusion tractography was used to provide the first direct evidence for a subcortical pathway from the retina to the amygdala, via the superior colliculus and pulvinar, that transmits visual stimuli signalling threat. A bias to orient toward threat was measured in a temporal order judgement saccade decision task, under monocular viewing, in a group of 19 healthy participants who also underwent diffusion weighted MR imaging. On each trial of the behavioural task a picture depicting threat was presented in one visual field and a competing non-threating stimulus in the other...
February 2, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29408817/prelemniscal-lesion-for-selective-improvement-of-parkinson-disease-tremor
#19
Francisco Velasco, Mauricio Esqueda-Liquidano, Ana Luisa Velasco, Maria Guadalupe García-Gomar
BACKGROUND: Selective improvement of symptoms may be required when treating Parkinson disease (PD) patients with a predominantly monosymptomatic clinical picture. OBJECTIVE: To define a target in prelemniscal radiation fibers (Raprl) related to the physiopathology of tremor evidenced by tractography. CASE REPORT: We report a patient with predominant unilateral rest and postural tremor, diagnosed as PD based on 80% improvement induced by the administration of L-DOPA/carbidopa, subsequently complicated by motor fluctuations, L-DOPA dyskinesia, and a reduced ON period...
February 6, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29403431/acquired-sleep-related-hypermotor-epilepsy-with-disrupted-white-matter-tracts-assessed-by-multishell-diffusion-magnetic-resonance-imaging
#20
Zahari N Tchopev, Ping-Hong Yeh, Greg W Morgan, Eric Meyer, Johanna M Wolf, John M Ollinger, Gerard P Riedy, Lisa C Young
Sleep-related hypermotor epilepsy (SHE) (previously frontal lobe epilepsy) is a rare seizure disorder commonly misdiagnosed or unrecognized, causing negative patient sequelae. While usually reported in familial studies, it is more commonly acquired. Diagnosis is a challenge due to its low incidence in comparison with the more common sleep disorders or psychogenic etiologies in the differential diagnosis. Diagnosis is scaled on degree of certainty based on described or clinically documented semiology, with video EEG as a helpful, but not necessary, adjunct...
2018: Frontiers in Neurology
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