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Diffusion tract imaging

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https://www.readbyqxmd.com/read/28823023/posttraumatic-stress-disorder-symptoms-and-white-matter-abnormalities-among-combat-exposed-veterans
#1
Kirstin Aschbacher, Synthia H Mellon, Owen M Wolkowitz, Clare Henn-Haase, Rachel Yehuda, Janine D Flory, Linda M Bierer, Duna Abu-Amara, Charles R Marmar, Susanne G Mueller
Posttraumatic stress disorder (PTSD) is associated with abnormalities in functional connectivity of a specific cortico-limbic network; however, less is known about white matter abnormalities providing structural connections for this network. This study investigated whether the diagnosis and symptoms of PTSD are associated with alterations in fractional anisotropy (FA), an index reflecting white matter organization, across six, a priori-defined tracts. White matter FA was quantified by diffusion tensor imaging using 3 T-MRI among 57 male, combat-exposed veterans with no history of moderate to severe head injuries or current alcohol dependence: 31 met criteria for PTSD and 26 were demographically comparable, combat-exposed controls without PTSD...
August 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28821748/anxiety-related-experience-dependent-white-matter-structural-differences-in-adolescence-a-monozygotic-twin-difference-approach
#2
Nagesh Adluru, Zhan Luo, Carol A Van Hulle, Andrew J Schoen, Richard J Davidson, Andrew L Alexander, H Hill Goldsmith
Anxiety is linked to deficits in structural and functional connectivity between limbic structures and pre-frontal cortices. We employed a monozygotic (MZ) twin difference design to examine the relationship between structural characteristics of the uncinate fasciculus (UF) measured by Diffusion Tensor Imaging (DTI) and anxiety symptoms in a sample of N = 100 monozygotic (genetically identical), adolescent twins. The MZ difference design allowed us focus on environmental factors that vary within twin pairs while controlling for genetic and environmental factors shared by twin pairs...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821657/fronto-parietal-structural-connectivity-in-childhood-predicts-development-of-functional-connectivity-and-reasoning-ability-a-large-scale-longitudinal-investigation
#3
Carter Wendelken, Emilio Ferrer, Simona Ghetti, Stephen Bailey, Laurie Cutting, Silvia A Bunge
Prior research points to a positive concurrent relationship between reasoning ability and both fronto-parietal structural connectivity, as measured by diffusion tensor imaging (e.g. Tamnes et al., 2010), and fronto-parietal functional connectivity, as measured by fMRI (e.g. Cocchi et al., 2014). Further, recent research demonstrates a link between reasoning ability and functional connectivity of two brain regions in particular: rostrolateral prefrontal cortex (RLPFC) and the inferior parietal lobe (IPL) (Wendelken et al...
August 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28818826/test-retest-and-interreader-reproducibility-of-semiautomated-atlas-based-analysis-of-diffusion-tensor-imaging-data-in-acute-cervical-spine-trauma-in-adult-patients
#4
D J Peterson, A M Rutman, D S Hippe, J G Jarvik, F H Chokshi, M R Reyes, C H Bombardier, M Mossa-Basha
BACKGROUND AND PURPOSE: DTI is a tool for microstructural spinal cord injury evaluation. This study evaluated the reproducibility of a semiautomated segmentation algorithm of spinal cord DTI. MATERIALS AND METHODS: Forty-two consecutive patients undergoing acute trauma cervical spine MR imaging underwent 2 axial DTI scans in addition to their clinical scan. The datasets were put through a semiautomated probabilistic segmentation algorithm that selected white matter, gray matter, and 24 individual white matter tracts...
August 17, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28817574/diffusion-tensor-imaging-profiles-reveal-specific-neural-tract-distortion-in-normal-pressure-hydrocephalus
#5
Nicole C Keong, Alonso Pena, Stephen J Price, Marek Czosnyka, Zofia Czosnyka, Elise E DeVito, Charlotte R Housden, Barbara J Sahakian, John D Pickard
BACKGROUND: The pathogenesis of normal pressure hydrocephalus (NPH) remains unclear which limits both early diagnosis and prognostication. The responsiveness to intervention of differing, complex and concurrent injury patterns on imaging have not been well-characterized. We used diffusion tensor imaging (DTI) to explore the topography and reversibility of white matter injury in NPH pre- and early after shunting. METHODS: Twenty-five participants (sixteen NPH patients and nine healthy controls) underwent DTI, pre-operatively and at two weeks post-intervention in patients...
2017: PloS One
https://www.readbyqxmd.com/read/28816545/role-of-diffusion-tensor-imaging-in-the-diagnosis-and-management-of-post-traumatic-anosmia
#6
Lilla Bonanno, Silvia Marino, Simona De Salvo, Rosella Ciurleo, Antonio Costa, Daniele Bruschetta, Demetrio Milardi, Galletti Francesco, Placido Bramanti, Fabrizia Caminiti
INTRODUCTION: Anosmia is a possible complication of Traumatic Brain Injury (TBI). Psychometric and electrophysiological methods of olfaction measure and Magnetic Resonance Imaging (MRI) are the tools to evaluate the post-traumatic olfactory loss. Diffusion Tensor Imaging (DTI) provides useful data for a better understanding of etiopathogenesis TBI-related anosmia, in particular the loss of neural connections and their eventual recovery over time. MATERIALS AND METHODS: This study describes a case of TBI-related anosmia...
August 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28815879/calibrated-imaging-reveals-altered-grey-matter-metabolism-related-to-white-matter-microstructure-and-symptom-severity-in-multiple-sclerosis
#7
Nicholas A Hubbard, Monroe P Turner, Minhui Ouyang, Lyndahl Himes, Binu P Thomas, Joanna L Hutchison, Shawheen Faghihahmadabadi, Scott L Davis, Jeremy F Strain, Jeffrey Spence, Daniel C Krawczyk, Hao Huang, Hanzhang Lu, John Hart, Teresa C Frohman, Elliot M Frohman, Darin T Okuda, Bart Rypma
Multiple sclerosis (MS) involves damage to white matter microstructures. This damage has been related to grey matter function as measured by standard, physiologically-nonspecific neuroimaging indices (i.e., blood-oxygen-level dependent signal [BOLD]). Here, we used calibrated functional magnetic resonance imaging and diffusion tensor imaging to examine the extent to which specific, evoked grey matter physiological processes were associated with white matter diffusion in MS. Evoked changes in BOLD, cerebral blood flow (CBF), and oxygen metabolism (CMRO2 ) were measured in visual cortex...
August 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28815853/changes-to-white-matter-microstructure-in-transient-ischemic-attack-a-longitudinal-diffusion-tensor-imaging-study
#8
Jennifer K Ferris, Jodi D Edwards, Jennifer A Ma, Lara A Boyd
Transient ischemic attack (TIA) is associated with localized ischemic changes, identifiable by diffusion-weighted imaging. Past research has not considered whether TIA is also associated with diffuse changes to white matter microstructure; further past work has not tracked changes longitudinally. Here we examine whole-brain changes in fractional anisotropy (FA) in individuals with TIA presenting with sensorimotor symptoms. Twenty individuals with a recent (within 30 days) TIA and 12 healthy older adults were recruited...
August 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28815625/association-of-transcallosal-motor-fibres-with-function-of-both-hands-after-unilateral-neonatal-arterial-ischemic-stroke
#9
Samuel Groeschel, Lucie Hertz-Pannier, Matthieu Delion, Sébastien Loustau, Béatrice Husson, Manoelle Kossorotoff, Cyrille Renaud, Sylvie Nguyen The Tich, Stéphane Chabrier, Mickael Dinomais
AIM: The objective of this study was to investigate the involvement of the motor fibres of the corpus callosum after unilateral neonatal arterial ischemic stroke (NAIS) of the middle cerebral artery territory and the relationship to both ipsilesional and contralesional hand function. METHOD: Using high-resolution structural magnetic resonance imaging (MRI), functional MRI, and magnetic resonance diffusion-tractography, we compared the midsagittal area of the motor part of the corpus callosum (defined by the fibres connecting the precentral gyri) between 33 7-year-old children after unilateral NAIS and 31 typically developing 7-year-old children...
August 17, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28813079/diffusion-tensor-imaging-of-brain-white-matter-in-huntington-gene-mutation-individuals
#10
Roberta Arb Saba, James H Yared, Thomas M Doring, Med Phys, Vanderci Borges, Henrique Ballalai Ferraz
Objective: To evaluate the role of the involvement of white matter tracts in huntingtin gene mutation patients as a potential biomarker of the progression of the disease. Methods: We evaluated 34 participants (11 symptomatic huntingtin gene mutation, 12 presymptomatic huntingtin gene mutation, and 11 controls). We performed brain magnetic resonance imaging to assess white matter integrity using diffusion tensor imaging, with measurement of fractional anisotropy...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28812201/effectiveness-of-navigation-guided-cyst-aspiration-before-resection-of-large-cystic-brain-tumors-a-proof-of-concept-for-more-radical-surgery
#11
Tae Hoon Roh, Kyoung Su Sung, Seok-Gu Kang, Ju Hyung Moon, Eui Hyun Kim, Sun Ho Kim, Jong Hee Chang
BACKGROUND: Resection of tumors close to the corticospinal tract (CST) carries a high risk of damage to the CST. For cystic tumors, aspirating the cyst before resection may reduce the risk of damage to vital structures. This study evaluated the effectiveness of cyst aspiration, by comparing the results before and after aspiration of diffusion tensor image (DTI) tractography. METHODS: This study enrolled 23 patients with large cystic brain tumors (>20 cm(3)) between 2012 and 2016...
August 16, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28803550/palliative-end-ileostomy-and-gastrojejunostomy-for-a-metastatic-distal-transverse-colonic-malignancy-complicated-by-a-proximal-duodenocolic-fistula-a-case-report
#12
Gnanaselvam Pamathy, Umesh Jayarajah, Yapa Hamillage Hemantha Gunathilaka, Sivasuriya Sivaganesh
BACKGROUND: Fistulae between the colon and upper gastrointestinal tract are distressing and uncommon complications of malignancies involving this region. We report a case of a middle-aged man with a locally advanced and metastatic distal transverse colon malignancy who presented with a duodenocolic fistula proximal to the primary tumor and underwent palliative surgery. CASE PRESENTATION: A 50-year-old Sri Lankan man presented to our hospital with a history of feculent vomiting of 1 week's duration preceded by worsening constipation and abdominal fullness of 2 months' duration...
August 14, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28797663/improvement-of-olfactory-function-after-sinus-surgery-correlates-with-white-matter-properties-measured-by-diffusion-tensor-imaging
#13
Daniel Güllmar, Tabea Seeliger, Hilmar Gudziol, Ulf K M Teichgräber, Jürgen R Reichenbach, Orlando Guntinas-Lichius, Thomas Bitter
Impaired olfaction is associated with a volume decrease in the olfactory bulb as well as in the gray matter of cortical olfactory areas. On the other hand, restitution of an impaired olfaction results in a regain of volume in these regions. Studies investigating similar changes in the cerebral white matter are virtually not existent. The aim of this prospective study therefore was to investigate cerebral white matter using magnetic resonance diffusion tensor imaging (DTI). 31 patients (54±13years) with olfactory impairment (chronic rhinosinusitis) and planned functional endoscopic sinus surgery (FESS) were included...
August 7, 2017: Neuroscience
https://www.readbyqxmd.com/read/28796748/diffusion-basis-spectral-imaging-detects-ongoing-brain-inflammation-in-virologically-well-controlled-hiv-patients
#14
Jeremy F Strain, Tricia H Burdo, Sheng-Kwei Song, Peng Sun, Omar El-Ghazzawy, Brittany Nelson, Elizabeth Westerhaus, Laurie Baker, Florin Vaida, Beau M Ances
Inflammation occurs after HIV infection and persists despite highly active antiretroviral therapy (HAART). Diffusion tensor imaging (DTI), measures HIV associated white matter changes, but can be confounded by inflammation. Currently, the influence of inflammation on white matter integrity in well-controlled HIV+ patients remains unknown. We used diffusion basis spectral imaging (DBSI) derived cellularity to isolate restricted water diffusion associated with inflammation separated from the anisotropic diffusion associated with axonal integrity...
August 5, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28796415/white-matter-tract-integrity-is-associated-with-antidepressant-response-to-lurasidone-in-bipolar-depression
#15
Martin J Lan, Harry Rubin-Falcone, Fatima Motiwala, Ying Chen, Jonathan W Stewart, David J Hellerstein, J John Mann, Patrick J McGrath
OBJECTIVES: Patients with bipolar disorder spend the most time in the depressed phase, and that phase is associated with the most morbidity and mortality. Treatment of bipolar depression lacks a test to determine who will respond to treatment. White matter disruptions have been found in bipolar disorder. Previous reports suggest that white matter disruptions may be associated with resistance to antidepressant medication, but this has never been investigated in a prospective study using a Food and Drug Administration (FDA)-approved medication...
August 10, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28796115/cerebral-white-matter-structure-is-disrupted-in-gulf-war-veterans-with-chronic-musculoskeletal-pain
#16
Stephanie M VanRiper, Andrew L Alexander, Kelli F Koltyn, Aaron J Stegner, Laura D Ellingson, Daniel J Destiche, Ryan J Dougherty, Jacob B Lindheimer, Dane B Cook
Chronic musculoskeletal pain (CMP) affects ∼25% of the 700,000 Veterans deployed during the Persian Gulf War (1990-91). The cause of their pain is unknown and there are no efficacious treatments. A small body of literature suggests that brain abnormalities exist in Gulf War Veterans (GVs), yet relationships between brain abnormalities and disease symptoms remain largely unexplored. Our purpose was to compare white matter (WM) integrity between GVCMP and matched, healthy Veteran controls (GVCO) and investigate relationships between cerebral WM integrity and symptoms...
August 8, 2017: Pain
https://www.readbyqxmd.com/read/28794981/a-test-retest-study-on-parkinson-s-ppmi-dataset-yields-statistically-significant-white-matter-fascicles
#17
Martin Cousineau, Pierre-Marc Jodoin, Félix C Morency, Verena Rozanski, Marilyn Grand'Maison, Barry J Bedell, Maxime Descoteaux
In this work, we propose a diffusion MRI protocol for mining Parkinson's disease diffusion MRI datasets and recover robust disease-specific biomarkers. Using advanced high angular resolution diffusion imaging (HARDI) crossing fiber modeling and tractography robust to partial volume effects, we automatically dissected 50 white matter (WM) fascicles. These fascicles connect deep nuclei (thalamus, putamen, pallidum) to different cortical functional areas (associative, motor, sensorimotor, limbic), basal forebrain and substantia nigra...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28783808/recrudescence-of-deficits-after-stroke-clinical-and-imaging-phenotype-triggers-and-risk-factors
#18
Mehmet A Topcuoglu, Esen Saka, Scott B Silverman, Lee H Schwamm, Aneesh B Singhal
Importance: Reemergence of previous stroke-related deficits (or poststroke recrudescence [PSR]) is an underrecognized and inadequately characterized phenomenon. Objective: To investigate the clinical features, triggers, and risk factors for PSR. Design, Setting, and Participants: This retrospective study incorporated a crossover cohort study to identify triggers and a case-control study to identify risk factors. The study used the Massachusetts General Hospital Research Patient Data Repository to identify patients for the period January 1, 2000, to November 30, 2015, who had a primary or secondary diagnosis of cerebrovascular disease, who underwent magnetic resonance imaging of the brain at least once, and whose inpatient or outpatient clinician note or discharge summary stated the term recrudescence...
August 7, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28780927/white-matter-microstructure-predicts-longitudinal-social-cognitive-outcomes-after-paediatric-traumatic-brain-injury-a-diffusion-tensor-imaging-study
#19
N P Ryan, S Genc, M H Beauchamp, K O Yeates, S Hearps, C Catroppa, V A Anderson, T J Silk
BACKGROUND: Deficits in social cognition may be among the most profound and disabling sequelae of paediatric traumatic brain injury (TBI); however, the neuroanatomical correlates of longitudinal outcomes in this domain remain unexplored. This study aimed to characterize social cognitive outcomes longitudinally after paediatric TBI, and to evaluate the use of sub-acute diffusion tensor imaging (DTI) to predict these outcomes. METHODS: The sample included 52 children with mild complex-severe TBI who were assessed on cognitive theory of mind (ToM), pragmatic language and affective ToM at 6- and 24-months post-injury...
August 7, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28774764/anatomical-targeting-of-the-optimal-location-for-thalamic-deep-brain-stimulation-in-patients-with-essential-tremor
#20
Nicolas K K King, Vibhor Krishna, Francesco Sammartino, Ausaf Bari, Gaddum Duemani Reddy, Mojgan Hodaie, Suneil K Kalia, Alfonso Fasano, Renato P Munhoz, Andres M Lozano, Clement Hamani
BACKGROUND: Thalamic deep brain stimulation (DBS) is an effective strategy for the treatment of essential tremor (ET). With limitations of imaging modalities, targeting largely relies on indirect methods. This study was designed to determine the optimal target for DBS in ET and construct a targeting method based on probabilistic maps. METHODS: Patients with ET who had sustained tremor reduction at 1-year and optimal microelectrode recordings were selected. Stimulation volume was individually modeled in standard space and a final optimal region was derived for the whole population...
July 31, 2017: World Neurosurgery
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