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Trigeminal pain

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https://www.readbyqxmd.com/read/28446645/hypothalamus-as-a-mediator-of-chronic-migraine-evidence-from-high-resolution-fmri
#1
Laura H Schulte, Angie Allers, Arne May
OBJECTIVE: To identify pathophysiologic mechanisms of migraine chronification using a recently standardized protocol for high-resolution brainstem imaging of trigeminal nociceptive stimulation. METHODS: Eighteen episodic migraineurs (EMs), 17 chronic migraineurs (CMs), and 19 healthy controls (HCs) underwent painful ammonia stimulation of the left nostril in a 3T MRI scanner. Functional images were acquired with a brainstem-optimized protocol for high-resolution echo-planar imaging...
April 26, 2017: Neurology
https://www.readbyqxmd.com/read/28442409/sinonasal-mucosal-melanoma-a-44-case-study-and-literature-analysis
#2
M Dréno, M Georges, F Espitalier, C Ferron, A Charnolé, B Dréno, O Malard
OBJECTIVES: Sinonasal mucosal melanoma is a rare disease, representing 4% of nasal cavity and paranasal sinus malignancies. The aim of this study was to assess the clinical characteristics, progression and treatment of this disease and to identify prognostic factors. MATERIAL AND METHODS: This retrospective review presents a cohort of 44 patients treated for a melanoma arising from the nasal cavity and paranasal sinuses, in the ENT Head and Neck Surgery Department of the University Hospital of Nantes (France) between 1988 and 2015...
April 22, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28440673/mechanisms-of-craniofacial-pain
#3
Juliana Geremias Chichorro, Frank Porreca, Barry Sessle
Aim To provide an overview of mechanisms underlying craniofacial pain; to highlight peripheral and central adaptations that may promote chronification of pain in craniofacial pain states such as migraine and temporomandibular disorders (TMD). Background Pain is a common symptom associated with disorders involving craniofacial tissues including the teeth and their supporting structures, the temporomandibular joint and the muscles of the head. Most acute painful craniofacial conditions are easily recognized and well managed, but others, especially those that are chronic (e...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28437509/thermal-perception-as-a-key-factor-for-assessing-effects-of-trigeminal-nerve-injury
#4
Hye-Kyoung Kim, Ki-Suk Kim, Mee-Eun Kim
AIMS: To conduct a functional examination using multimodal exploration of a sample of patients with iatrogenic trigeminal nerve injury to understand the underlying mechanisms of neuropathic pain following trigeminal nerve injury. METHODS: Subjective and objective symptoms and responses to thermal and electrical quantitative sensory testing (QST) were evaluated in 85 patients with unilateral trigeminal nerve injury. Objective symptoms were measured by seven clinical sensory tests...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28434965/trochlear-schwannoma-presenting-with-isolated-trigeminal-neuralgia
#5
Cody L Nesvick, Avital Perry, Christopher S Graffeo, Aditya Raghunathan, Julie E Hammack, Jamie J Van Gompel
BACKGROUND: Schwannomas arising from the cranial nerves controlling extraocular eye movements are very rare and usually present with some degree of diplopia. CASE DESCRIPTION: We report a 50-year-old woman who presented with isolated left-sided trigeminal neuralgia of six months' duration. Imaging demonstrated a homogeneously enhancing mass in the left ambient cistern, and the patient was taken to the operating room for resection. A retrosigmoid approach was used, and the mass was directly visualized arising from the trochlear nerve and compressing on the dorsal root entry zone of the trigeminal nerve...
April 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28432602/sphenopalatine-ganglion-block-in-the-management-of-chronic-headaches
#6
REVIEW
Jeffery Mojica, Bi Mo, Andrew Ng
PURPOSE OF REVIEW: Sphenopalatine ganglion (SPG) block has been used by clinicians in the treatment of a variety of headache disorders, facial pain syndromes, and other facial neuralgias. The sensory and autonomic fibers that travel through the SPG provided the scientific rationale for symptoms associated with these head and neck syndromes. Yet, despite the elucidation of this pathogenic target, the optimal method to block its pain-producing properties has not been determined. Clinicians have developed various invasive and non-invasive techniques, each of which has shown variable rates of success...
June 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28430860/increased-brainstem-perfusion-but-no-blood-brain-barrier-disruption-during-attacks-of-migraine-with-aura
#7
Anders Hougaard, Faisal M Amin, Casper E Christensen, Samaira Younis, Frauke Wolfram, Stig P Cramer, Henrik B W Larsson, Messoud Ashina
The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed by migraine headache. It is currently not understood how the aura symptoms are related to the headache phase of migraine. Animal studies suggest that cortical spreading depression, the likely mechanism of migraine aura, causes disruption of the blood-brain barrier and noxious stimulation of trigeminal afferents leading to activation of brainstem nuclei and triggering of migraine headache...
April 18, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28426550/neuropathic-pain-after-chronic-nerve-constriction-may-not-correlate-with-chloride-dysregulation-in-mouse-trigeminal-nucleus-caudalis-neurons
#8
Alberto Castro, Ying Li, Charles Raver, Ramesh Chandra, Radi Masri, Mary Kay Lobo, Asaf Keller
Changes in chloride reversal potential in rat spinal cord neurons have previously been associated with persistent pain in nerve injury and inflammation models. These changes correlate with a decrease in the expression of the potassium% chloride transporter, KCC2, and with increases in neuronal excitability. Here, we test the hypothesis that similar changes occur in mice with neuropathic pain induced by chronic constriction injury of the trigeminal infraorbital nerve (CCI¬-ION). This model allows us to distinguish an acute pain phase (3-¬5 days after injury) from a persistent pain phase (12¬-14 days after CCI-¬ION)...
April 18, 2017: Pain
https://www.readbyqxmd.com/read/28425324/persistent-idiopathic-facial-pain
#9
Rafael Benoliel, Charly Gaul
Background Persistent idiopathic facial pain (PIFP) is a chronic disorder recurring daily for more than two hours per day over more than three months, in the absence of clinical neurological deficit. PIFP is the current terminology for Atypical Facial Pain and is characterized by daily or near daily pain that is initially confined but may subsequently spread. Pain cannot be attributed to any pathological process, although traumatic neuropathic mechanisms are suspected. When present intraorally, PIFP has been termed 'Atypical Odontalgia', and this entity is discussed in a separate article in this special issue...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28425266/nitroglycerin-challenge-induces-lateralized-headache-in-nasociliarynerve-ligated-rats-implications-for-chronic-migraine
#10
Didem Akçali, Ahmet Deniz Belen, Avni Babacan, Hayrunnisa Bolay
BACKGROUND/AIM: Chronic migraine is a common debilitating disease with limited treatment options. We aimed to develop a novel model for chronic migraine by ligating the nasociliary nerve (NCL) and administering nitroglycerin (NTG) to exacerbate acute headache attacks. MATERIALS AND METHODS: Exacerbation of the headache was induced by NTG (10 mg/kg, subcutaneously) administered to male Wistar rats (n = 36) 14 days following unilateral NCL. Cutaneous and cold allodynia was tested using Von Frey (VF) filaments and acetone, respectively...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424990/proteomic-analysis-of-the-hippocampus-in-mouse-models-of-trigeminal-neuralgia-and-inescapable-shock-induced-depression
#11
Qing-Huan Guo, Qing-He Tong, Ning Lu, Hong Cao, Liu Yang, Yu-Qiu Zhang
To investigate the behavioral and biomolecular similarity between neuralgia and depression, a trigeminal neuralgia (TN) mouse model was established by constriction of the infraorbital nerve (CION) to mimic clinical trigeminal neuropathic pain. A mouse learned helplessness (LH) model was developed to investigate inescapable foot-shock-induced psychiatric disorders like depression in humans. Mass spectrometry was used to assess changes in the biomolecules and signaling pathways in the hippocampus from TN or LH mice...
April 19, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28404687/selective-calcium-dependent-inhibition-of-atp-gated-p2x3-receptors-by-bisphosphonates-induced-endogenous-atp-analogue-apppi
#12
Yevheniia Ishchenko, Anastasia Shakirzyanova, Raisa Giniatullina, Andrei Skorinkin, Geneviev Bart, Petri Turhanen, Jorma Maatta, Jukka Monkkonen, Rashid Giniatullin
Pain is the most unbearable symptom accompanying primary bone cancers and bone metastases. Bone resorptive disorders are often associated with hypercalcemia contributing to the pathological process. Nitrogen-containing bisphosphonates (NBP) are efficiently used to treat bone-cancers and metastases. NBP, apart from their toxic effect on cancer cells, also provide analgesia via poorly understood mechanisms. We have previously shown, that NBP, by inhibiting the mevalonate pathway, induced the formation of the novel ATP-analogues such as ApppI which can potentially be involved in NBP analgesia...
April 12, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28403646/neuropathic-orofacial-pain-facts-and-fiction
#13
Lene Baad-Hansen, Rafael Benoliel
Definition and taxonomy This review deals with neuropathic pain of traumatic origin affecting the trigeminal nerve, i.e. painful post-traumatic trigeminal neuropathy (PTTN). Symptomatology The clinical characteristics of PTTN vary considerably, partly due to the type and extent of injury. Symptoms involve combinations of spontaneous and evoked pain and of positive and negative somatosensory signs. These patients are at risk of going through unnecessary dental/surgical procedures in the attempt to eradicate the cause of the pain, due to the fact that most dentists only rarely encounter PTTN...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28399652/facial-presentations-of-primary-headache-disorders
#14
Yair Sharav, Zaza Katsarava, Andrew Charles
Background Many patients with mid-face or lower face craniofacial pain are diagnosed, based on accompanying signs and symptoms and features other than location, as either atypical migraines or atypical TACs. Distinguishing features of headache disorders as a cause of facial pain include the temporal pattern of pain, associated symptoms including light and sound sensitivity and nausea, cranial autonomic symptoms, and the lack of local triggering among others. Results An intraoral neurovascular pain has been observed, and was termed neurovascular orofacial pain (NVOP)...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28396882/afferent-fiber-remodeling-in-the-somatosensory-thalamus-of-mice-as-a-neural-basis-of-somatotopic-reorganization-in-the-brain-and-ectopic-mechanical-hypersensitivity-after-peripheral-sensory-nerve-injury
#15
Yuichi Takeuchi, Hironobu Osaki, Yuki Yagasaki, Yoko Katayama, Mariko Miyata
Plastic changes in the CNS in response to peripheral sensory nerve injury are a series of complex processes, ranging from local circuit remodeling to somatotopic reorganization. However, the link between circuit remodeling and somatotopic reorganization remains unclear. We have previously reported that transection of the primary whisker sensory nerve causes the abnormal rewiring of lemniscal fibers (sensory afferents) on a neuron in the mouse whisker sensory thalamus (V2 VPM). In the present study, using transgenic mice whose lemniscal fibers originate from the whisker sensory principle trigeminal nucleus (PrV2) are specifically labeled, we identified that the transection induced retraction of PrV2-originating lemniscal fibers and invasion of those not originating from PrV2 in the V2 VPM...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28392449/clinical-analysis-and-surgical-treatment-of-trigeminal-neuralgia-caused-by-vertebrobasilar-dolichoectasia-a-retrospective-study
#16
Shoujia Sun, Wei Jiang, Junwen Wang, Pan Gao, Xiaojing Zhang, Liwu Jiao, Weihua Liu, Kai Shu, Ting Lei
BACKGROUND: Trigeminal neuralgia (TN) caused by vertebrobasilar dolichoectasia (VBD) is rare and needs further exploration. The purpose of this study is to investigate the clinical features and surgical treatment of TN caused by VBD. METHODS: 15 patients with TN caused by VBD were included in our study. The patient data regarding clinical characteristics, neuroimaging presentations, intraoperative findings and treatment outcomes were analyzed retrospectively. Moreover, the previous relevant literature was reviewed simultaneously...
April 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28387834/pain-extent-is-associated-with-the-emotional-and-physical-burdens-of-chronic-tension-type-headache-but-not-with-depression-or-anxiety
#17
María Palacios-Ceña, Marco Barbero, Deborah Falla, Filippo Ghirlanda, Lars Arend-Nielsen, César Fernández-de-Las-Peñas
Objective.:  Earlier studies suggest that pain extent, extracted from the patients' pain drawings, can help clinicians to identify people with central sensitization or worse clinical features. Our aim was to investigate possible associations between perceived pain extent and clinical pain features, burden of headache, psychological outcomes, and pressure sensitivity in people with chronic tension-type headache (CTTH). Methods.:  Ninety-nine people (27% men) with CTTH reported their pain on four different body charts representing the head and neck...
April 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28377244/trigeminal-neuralgia-toward-a-multimodal-approach
#18
REVIEW
Alfio Spina, Pietro Mortini, Federica Alemanno, Elise Houdayer, Sandro Iannaccone
OBJECTIVES: Trigeminal neuralgia (TN) is the most common cranial neuralgia in adults, with a slight prevalence in women. Antiepileptic drugs represent the mainstay of the medical treatment, whereas microvascular decompression is the best option in case of neurovascular conflict. Although these treatments showed good rate of efficacy, they can be contraindicated in some patients and more than 50% of patients undergoing these treatments will present recurrence of pain in the following months...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28375911/trigeminal-neuralgia
#19
Giorgio Cruccu
PURPOSE OF REVIEW: Although trigeminal neuralgia is well known to neurologists, recent developments in classification and clinical diagnosis, new MRI methods, and a debate about surgical options necessitate an update on the topic. RECENT FINDINGS: Currently, a worldwide controversy exists regarding the classification, diagnostic process, and surgical treatment of trigeminal neuralgia. This controversy has been caused on one side by the recognition that some 50% of patients with trigeminal neuralgia, apart from characteristic paroxysmal attacks, also have continuous pain in the same territory, which results in greater diagnostic difficulties and is associated with a lower response to medical and surgical treatments...
April 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28366470/ascending-projections-of-nociceptive-neurons-from-trigeminal-subnucleus-caudalis-a-population-approach
#20
Hiroto Saito, Ayano Katagiri, Shinji Okada, Lou Mikuzuki, Asako Kubo, Tatsuro Suzuki, Kinuyo Ohara, Jun Lee, Nobuhito Gionhaku, Toshimitsu Iinuma, David A Bereiter, Koichi Iwata
Second-order neurons in trigeminal subnucleus caudalis (Vc) and upper cervical spinal cord (C1) are critical for craniofacial pain processing and project rostrally to terminate in: ventral posteromedial thalamic nucleus (VPM), medial thalamic nuclei (MTN) and parabrachial nuclei (PBN). The contribution of each region to trigeminal nociception was assessed by the number of phosphorylated extracellular signal-regulated kinase-immunoreactive (pERK-IR) neurons co-labeled with fluorogold (FG). The phenotype of pERK-IR neurons was further defined by the expression of neurokinin 1 receptor (NK1)...
March 31, 2017: Experimental Neurology
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