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Cortical thickness

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https://www.readbyqxmd.com/read/29143946/multi-scale-account-of-the-network-structure-of-macaque-visual-cortex
#1
Maximilian Schmidt, Rembrandt Bakker, Claus C Hilgetag, Markus Diesmann, Sacha J van Albada
Cortical network structure has been extensively characterized at the level of local circuits and in terms of long-range connectivity, but seldom in a manner that integrates both of these scales. Furthermore, while the connectivity of cortex is known to be related to its architecture, this knowledge has not been used to derive a comprehensive cortical connectivity map. In this study, we integrate data on cortical architecture and axonal tracing data into a consistent multi-scale framework of the structure of one hemisphere of macaque vision-related cortex...
November 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29143443/multiscale-characterisation-of-cortical-bone-composition-microstructure-and-nanomechanical-properties-in-experimentally-induced-osteoporosis
#2
Furqan A Shah, Adrian Stoica, Carina Cardemil, Anders Palmquist
Cortical bone plays a vital role in determining overall bone strength. We investigate the structural, compositional, and nanomechanical properties of cortical bone following ovariectomy (OVX) of 12 week old Sprague Dawley rats, since this animal model is frequently employed to evaluate the performance of implantable biomaterials in compromised bone healing conditions. Morphological parameters and material properties of bone in the geometrical centre of the femoral cortex were investigated four and eight weeks post-OVX and in unoperated controls (Ctrl), using X-ray micro-computed tomography, backscattered electron scanning electron microscopy, Raman spectroscopy, and nanoindentation...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29141793/information-processing-deficits-as-a-driving-force-for-memory-impairment-in-ms-a-cross-sectional-study-of-memory-functions-and-mri-in-early-and-late-stage-ms
#3
Wolfgang Köhler, Martin Fischer, Peter Bublak, Jürgen H Faiss, Frank Hoffmann, Annett Kunkel, Michael Sailer, Matthias Schwab, Erhard Stadler, Uwe K Zettl, Iris-Katharina Penner
BACKGROUND: Memory impairment (MI) is a common symptom of MS. Previous studies were conflicting in respect to the possible existence of early MI and the role of hippocampal atrophy. The objective of this study was to investigate MI and structural MRI correlates in homogenous groups of early and late MS, controlling for a potential information-processing speed (IPS) deficit, and utilizing multiple memory test paradigms. METHODS: 152 individually matched subjects were recruited: early MS (EMS, N = 25, disease duration 1...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29140370/mandibular-bone-structure-analysis-using-cone-beam-computed-tomography-vs-primary-implant-stability-an-ex-vivo-study
#4
Ruben Pauwels, Somchai Sessirisombat, Soontra Panmekiate
PURPOSE: To evaluate the relationship between mandibular bone structure parameters measured on preimplant cone beam computed tomography (CBCT) images and primary implant stability. MATERIALS AND METHODS: Twenty-one hemimandibles were scanned on the 3D Accuitomo 170 CBCT. Next, an implant was placed in each hemimandible, after which insertion torque and implant stability quotient (ISQ) measurements were acquired. The following measurements were performed on the preimplant CBCT scans: bone surface, bone volume, fractal dimension, connectivity, trabecular thickness and spacing, and skeleton analysis...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29139130/less-cortical-thickness-in-patients-with-persistent-post-traumatic-headache-compared-with-healthy-controls-an-mri-study
#5
Catherine D Chong, Visar Berisha, Chia-Chun Chiang, Katherine Ross, Todd J Schwedt
OBJECTIVE: To investigate differences in cortical thickness in patients with persistent post-traumatic headache (PPTH) relative to healthy controls and to interrogate whether cortical morphology relates to headache burden (headache frequency, years with post-traumatic headache, PTH) in patients with PPTH. BACKGROUND: PTHs are one of the most common symptoms following concussion. In some patients, PTHs continue for longer than three months and are classified as PPTH...
November 15, 2017: Headache
https://www.readbyqxmd.com/read/29136119/the-bat-as-a-new-model-of-cortical-development
#6
Verónica Martínez-Cerdeño, Jasmin Camacho, Jeanelle Ariza, Hailee Rogers, Kayla Horton-Sparks, Anna Kreutz, Richard Behringer, John J Rasweiler, Stephen C Noctor
The organization of the mammalian cerebral cortex shares fundamental features across species. However, while the radial thickness of grey matter varies within one order of magnitude, the tangential spread of the cortical sheet varies by orders of magnitude across species. A broader sample of model species may provide additional clues for understanding mechanisms that drive cortical expansion. Here, we introduce the bat Carollia perspicillata as a new model species. The brain of C. perspicillata is similar in size to that of mouse but has a cortical neurogenic period at least 5 times longer than mouse, and nearly as long as that of the rhesus macaque, whose brain is 100 times larger...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29136105/same-genes-different-brains-neuroanatomical-differences-between-monozygotic-twins-discordant-for-musical-training
#7
Örjan de Manzano, Fredrik Ullén
Numerous cross-sectional and observational longitudinal studies show associations between expertise and regional brain anatomy. However, since these designs confound training with genetic predisposition, the causal role of training remains unclear. Here, we use a discordant monozygotic (identical) twin design to study expertise-dependent effects on neuroanatomy using musical training as model behavior, while essentially controlling for genetic factors and shared environment of upbringing. From a larger cohort of monozygotic twins, we were able to recruit 18 individuals (9 pairs) that were highly discordant for piano practice...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29135041/risk-factors-for-tibial-damage-associated-with-the-modified-maquet-technique-in-174-stifles
#8
Michael D Lefebvre, Olivier R Broux, Nicolas P Barthélémy, Martin Hamon, Evelyne V Moyse, Bernard M Bouvy, Marc H Balligand
OBJECTIVE: To identify risk factors for tibial damage associated with the modified Maquet technique (MMT) in dogs with cranial cruciate ligament (CCL) disease. STUDY DESIGN: Retrospective study. SAMPLE POPULATION: One hundred and seventy-four stifles from 147 client-owned dogs. METHODS: Medical records of dogs diagnosed with CCL disease and treated with the current version of MMT were reviewed. Dogs were included if immediate postoperative radiographs were available...
November 14, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29134242/serum-parathyroid-hormone-is-associated-with-increased-cortical-porosity-of-the-inner-transitional-zone-at-the-proximal-femur-in-postmenopausal-women-the-troms%C3%A3-study
#9
M Osima, T T Borgen, M Lukic, G Grimnes, R M Joakimsen, E F Eriksen, Å Bjørnerem
Serum parathyroid hormone (PTH) was associated with increased bone turnover markers and cortical porosity of the inner transitional zone at the proximal femur. These results suggest that PTH through increased intracortical bone turnover leads to trabecularisation of inner cortical bone in postmenopausal women. INTRODUCTION: Vitamin D deficiency leads to secondary hyperparathyroidism and increased risk for fractures, whereas its association with cortical porosity is less clear. We tested (i) whether serum 25-hydroxyvitamin D (25(OH)D) and PTH were associated with cortical porosity and (ii) whether the associations of 25(OH)D) and PTH with fracture risk are dependent on cortical porosity...
November 14, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29133259/loss-of-pit-2-results-in-abnormal-bone-development-and-decreased-bone-mineral-density-and-length-in-mice
#10
Shunsuke Yamada, Mary C Wallingford, Suhaib Borgeia, Timothy C Cox, Cecilia M Giachelli
Normal bone mineralization requires phosphate oversaturation in bone matrix vesicles, as well as normal regulation of phosphate metabolism via the interplay among bone, intestine, and kidney. In turn, derangement of phosphate metabolism greatly affects bone function and structure. The type III sodium-dependent phosphate transporters, PiT-1 and PiT-2, are believed to be important in tissue phosphate metabolism and physiological bone formation, but their requirement and molecular roles in bone remain poorly investigated...
November 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29133062/anatomical-and-physiological-basis-of-continuous-spike-wave-of-sleep-syndrome-after-early-thalamic-lesions
#11
Alberto Leal, Eulália Calado, José P Vieira, Carla Mendonça, José C Ferreira, Hugo Ferreira, Daniel Carvalho, Fátima Furtado, Roseli Gomes, José P Monteiro
OBJECTIVE: Early neonatal thalamic lesions account for about 14% of continuous spike-wave of sleep (CSWS) syndrome, representing the most common etiology in this epileptic encephalopathy in children, and promise useful insights into the pathophysiology of the disease. METHODS: We describe nine patients with unilateral neonatal thalamic lesions which progressed to CSWS. Longitudinal whole-night and high-density electroencephalograms (EEGs) were performed, as well as detailed imaging and clinical evaluation...
November 10, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29131878/association-of-brain-structure-changes-and-cognitive-function-with-combination-antiretroviral-therapy-in-hiv-positive-individuals
#12
Ryan Sanford, Lesley K Fellows, Beau M Ances, D Louis Collins
Importance: Despite the introduction of combination antiretroviral therapy (cART), HIV-associated neurocognitive disorders continue to be a problem for treated HIV-positive individuals. The cause of this impairment remains unclear. Objective: To determine if detectable brain changes occur during a 2-year period in HIV-positive individuals who were aviremic and treated with cART. Design, Setting, and Participants: In this longitudinal case-control study, participants underwent neuroimaging and neuropsychological assessment approximately 2 years apart...
November 13, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29131517/a-postmortem-study-of-frontal-and-temporal-gyri-thickness-and-cell-number-in-human-obesity
#13
Erick Gómez-Apo, Adrián García-Sierra, Juan Silva-Pereyra, Virgilia Soto-Abraham, Alejandra Mondragón-Maya, Verónica Velasco-Vales, Linda S Pescatello
OBJECTIVE: This study aimed to compare cortex thickness and neuronal cell density in postmortem brain tissue from people with overweight or obesity and normal weight. METHODS: The cortex thickness and neuron density of eight donors with overweight or obesity (mean = 31.6 kg/m(2) ; SD = 4.35; n = 8; 6 male) and eight donors with normal weight (mean = 21.8 kg/m(2) ; SD = 1.5; n = 8; 5 male) were compared. All participants were Mexican and lived in Mexico City...
November 13, 2017: Obesity
https://www.readbyqxmd.com/read/29129406/neuropeptide-y-y2-antagonist-treated-ovariectomized-mice-exhibit-greater-bone-mineral-density
#14
K L Seldeen, P G Halley, C H Volmar, M A Rodríguez, M Hernandez, M Pang, S K Carlsson, L J Suva, C Wahlestedt, B R Troen, S P Brothers
Osteoporosis, a disease characterized by progressive bone loss and increased risk of fracture, often results from menopausal loss of estrogen in women. Neuropeptide Y has been shown to negatively regulate bone formation, with amygdala specific deletion of the Y2 receptor resulting in increased bone mass in mice. In this study, ovariectomized (OVX) mice were injected once daily with JNJ-31020028, a brain penetrant Y2 receptor small molecule antagonist to determine the effects on bone formation. Antagonist treated mice had reduced weight and showed increased whole-body bone mineral density compared to vehicle-injected mice...
November 7, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29128929/freezing-of-gait-in-parkinson-s-disease-gray-and-white-matter-abnormalities
#15
Sara Pietracupa, Antonio Suppa, Neeraj Upadhyay, Costanza Giannì, Giovanni Grillea, Giorgio Leodori, Nicola Modugno, Francesca Di Biasio, Alessandro Zampogna, Claudio Colonnese, Alfredo Berardelli, Patrizia Pantano
Freezing of gait (FOG) is a disabling disorder that often affects Parkinson's disease (PD) patients in advanced stages of the disease. To study structural gray matter (GM) and white matter (WM) changes in PD patients with and without FOG, twenty-one PD patients with FOG (PD-FOG), 16 PD patients without FOG (PD-nFOG) and 19 healthy subjects (HS) underwent a standardized MRI protocol. For the gray matter evaluation, cortical volume (CV), cortical thickness (CTh), and surface area (SA) were analyzed using the FreeSurfer pipeline...
November 11, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29128580/reduction-of-protein-phosphatase-2a-c%C3%AE-promotes-in-vivo-bone-formation-and-adipocyte-differentiation
#16
Kaya Yoshida, Jumpei Teramachi, Kenta Uchibe, Mika Ikegame, Lihong Qiu, Di Yang, Hirohiko Okamura
Serine/threonine protein phosphatase 2A (PP2A) regulates diverse physiological processes such as cell cycle, growth, apoptosis, and signal transduction. Previously, we demonstrated that silencing of the α-isoform of PP2A catalytic subunit (PP2A Cα) in osteoblasts accelerated osteoblast differentiation, whereas its overexpression suppressed differentiation. In this study, we examined the role of PP2A Cα in in vivo bone formation by generating transgenic mice (PP2A-Tg), in which the dominant negative form of PP2A Cα was specifically expressed in osteoblasts...
November 8, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29127344/catabolic-effects-of-human-pth-1-34-on-bone-requirement-of-monocyte-chemoattractant-protein-1-in-murine-model-of-hyperparathyroidism
#17
Jawed A Siddiqui, Joshua Johnson, Carole Le Henaff, Claudine L Bitel, Joseph A Tamasi, Nicola C Partridge
The bone catabolic actions of parathyroid hormone (PTH) are seen in patients with hyperparathyroidism, or with infusion of PTH in rodents. We have previously shown that the chemokine, monocyte chemoattractant protein-1 (MCP-1), is a mediator of PTH's anabolic effects on bone. To determine its role in PTH's catabolic effects, we continuously infused female wild-type (WT) and MCP-1(-/-) mice with hPTH or vehicle. Microcomputed tomography (µCT) analysis of cortical bone showed that hPTH-infusion induced significant bone loss in WT mice...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29126935/age-dependent-and-region-specific-alteration-of-parvalbumin-neurons-and-perineuronal-nets-in-the-mouse-cerebral-cortex
#18
Hiroshi Ueno, Keizo Takao, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Motoi Okamoto, Shozo Aoki, Takeshi Ishihara
Cognitive function declines with age. Such function depends on γ-oscillation in the frontal cortex. Pyramidal neurons, and the parvalbumin-expressing interneurons (PV neurons) that control them, are important for the generation of γ-oscillation. The mechanism by which cognitive function declines is unclear. Perineuronal nets (PNNs) mainly surround the soma and proximal dendrites and axon segments of PV neurons in the cerebral cortex. Previous evidence indicates that PNNs inhibit neural plasticity. If this is true, an increase in the number of neurons surrounded by PNNs or in the thickness or density of the PNNs around neurons could decrease plasticity in the cortex...
November 7, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29126813/automated-immunohistochemical-method-to-analyze-large-areas-of-the-human-cortex
#19
Mohamad Abbass, Kathleen Trought, David Long, Anton Semechko, Albert H C Wong
BACKGROUND: There have been inconsistencies in the histological abnormalities found in the cerebral cortex from patients with schizophrenia, bipolar disorder and major depression. Discrepancies in previously published reports may arise from small sample sizes, inconsistent methodology and biased cell counting. New METHOD: We applied automated quantification of neuron density, neuron size and cortical layer thickness in vast regions of human cortex in psychiatric patients. This method accurately segments DAPI positive cells that are also stained with CUX2 and FEZF2...
November 7, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29126229/osteoblast-amp-activated-protein-kinase-regulates-postnatal-skeletal-development-in-male-mice
#20
Ippei Kanazawa, Ayumu Takeno, Ken-Ichiro Tanaka, Masakazu Notsu, Toshitsugu Sugimoto
Studies have shown that AMP-activated protein kinase (AMPK), a crucial regulator of energy homeostasis, plays important roles in osteoblast differentiation and mineralization. However, little is known about in vivo roles of osteoblastic AMPK in bone development. Thus, to investigate in vivo roles of osteoblast AMPK, we conditionally inactivated Ampk in osterix (Osx)-expressing cells by crossing Osx-Cre mice with floxed AMPKα1 to generate mice lacking AMPKα1 in osteoblasts (Ampk-/- mice). Compared with wild-type and Ampk+/- mice, Ampk-/- mice displayed retardation of postnatal bone development, although bone deformity was not observed at birth...
November 3, 2017: Endocrinology
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