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https://www.readbyqxmd.com/read/29323900/enantioselective-1-2-anionotropic-rearrangement-of-acylsilane-through-bisguanidinium-silicate-ion-pair
#1
Weidi Cao, Davin Tan, Richmond Lee, Choon-Hong Tan
Highly enantioselective bisguanidinium-catalyzed tandem rearrangements of acylsilanes are reported. The acylsilanes were activated via an addition of fluoride on the silicon to form a penta-coordinate anionic silicate intermediate. The silicate then underwent alkyl or aryl group migration from the silicon atom to the neighboring carbonyl carbon atom (1,2-anionotropic rearrangement), followed by [1,2]-Brook rearrangement to provide the secondary alcohols in high yields with excellent enantioselectivities (up to 95% ee)...
January 11, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29323728/3d-reconstruction-of-prostate-cancer-architecture-with-serial-immunohistochemical-sections-hallmarks-of-tumour-growth-tumour-compartmentalization-and-implications-for-grading-and-heterogeneity
#2
Yuri Tolkach, Stefan Thomann, Glen Kristiansen
BACKGROUND: Conventional morphology of the prostate cancer (PCA) considers only two-dimensional architecture of the tumour. Our aim was to examine the feasibility of 3D-reconstruction of tumour morphology based on multiple consecutive histological sections and to decipher relevant features of PCA architecture. METHODS: Seventy-five consecutive histological sections (5μm) of a typical prostate adenocarcinoma (Gleason-Score 3+4=7) were immunostained (Pan-Cytokeratin) and scanned for further 3D reconstructions with Fiji / ImageJ software...
January 11, 2018: Histopathology
https://www.readbyqxmd.com/read/29323294/terminal-pleistocene-alaskan-genome-reveals-first-founding-population-of-native-americans
#3
J Víctor Moreno-Mayar, Ben A Potter, Lasse Vinner, Matthias Steinrücken, Simon Rasmussen, Jonathan Terhorst, John A Kamm, Anders Albrechtsen, Anna-Sapfo Malaspinas, Martin Sikora, Joshua D Reuther, Joel D Irish, Ripan S Malhi, Ludovic Orlando, Yun S Song, Rasmus Nielsen, David J Meltzer, Eske Willerslev
Despite broad agreement that the Americas were initially populated via Beringia, the land bridge that connected far northeast Asia with northwestern North America during the Pleistocene epoch, when and how the peopling of the Americas occurred remains unresolved. Analyses of human remains from Late Pleistocene Alaska are important to resolving the timing and dispersal of these populations. The remains of two infants were recovered at Upward Sun River (USR), and have been dated to around 11.5 thousand years ago (ka)...
January 11, 2018: Nature
https://www.readbyqxmd.com/read/29306627/favourable-outcomes-of-endovascular-total-aortic-arch-repair-via-needle-based-in-situ-fenestration-at-a-mean-follow-up-of-5-4%C3%A2-months
#4
Tao Shang, Lu Tian, Dong-Lin Li, Zi-Heng Wu, Hong-Kun Zhang
OBJECTIVES: Endovascular repair of aortic arch pathologies remains challenging. Recently, needle based in situ fenestration (ISF) has shown great potential in endovascular total aortic arch repair (ETAAR). This study aimed to evaluate the feasibility, effectiveness, and safety of ETAAR via needle based ISF, and to present initial experience with this technique. DESIGN AND METHODS: Patients who met the inclusion criteria were enrolled in this prospective study. The supra-arch branches were manually punctured in a retrograde manner using liver biopsy needles (18 gauge/30 cm) in the left common carotid artery (LCCA) and brachiocephalic trunk (BCT), and endo-puncture system or aspiration biopsy needles (21-gauge) in the left subclavian artery (LSA)...
January 3, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29306626/mid-term-outcomes-of-endovascular-repair-of-ruptured-thoraco-abdominal-aortic-aneurysms-with-off-the-shelf-branched-stent-grafts
#5
Kiattisak Hongku, Björn Sonesson, Katarina Björses, Jan Holst, Timothy Resch, Nuno V Dias
OBJECTIVE: To assess the mid-term outcomes and feasibility of branched endovascular repair (b-EVAR) of ruptured thoracoabdominal aortic aneurysms (rTAAAs). METHODS: All patients undergoing b-EVAR of rTAAAs between 2011 and 2016 were included. Pre-, intra and postoperative imaging was reviewed to assess technical success, outcomes, and feasibility of b-EVAR in the emergent setting. RESULTS: Eleven emergency b-EVAR of rTAAAs (10 aneurysms and 1 chronic dissection) were performed using off-the-shelf (OTS) branched stentgrafts...
January 3, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29295984/rad54-n-terminal-domain-is-a-dna-sensor-that-couples-atp-hydrolysis-with-branch-migration-of-holliday-junctions
#6
Nadish Goyal, Matthew J Rossi, Olga M Mazina, Yong Chi, Robert L Moritz, Bruce E Clurman, Alexander V Mazin
In eukaryotes, RAD54 catalyzes branch migration (BM) of Holliday junctions, a basic process during DNA repair, replication, and recombination. RAD54 also stimulates RAD51 recombinase and has other activities. Here, we investigate the structural determinants for different RAD54 activities. We find that the RAD54 N-terminal domain (NTD) is responsible for initiation of BM through two coupled, but distinct steps; specific binding to Holliday junctions and RAD54 oligomerization. Furthermore, we find that the RAD54 oligomeric state can be controlled by NTD phosphorylation at S49, a CDK2 consensus site, which inhibits RAD54 oligomerization and, consequently, BM...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29288383/transcription-factors-regulating-embryonic-development-of-pulmonary-vasculature
#7
Craig Bolte, Jeffrey A Whitsett, Tanya V Kalin, Vladimir V Kalinichenko
Lung morphogenesis is a highly orchestrated process beginning with the appearance of lung buds on approximately embryonic day 9.5 in the mouse. Endodermally derived epithelial cells of the primitive lung buds undergo branching morphogenesis to generate the tree-like network of epithelial-lined tubules. The pulmonary vasculature develops in close proximity to epithelial progenitor cells in a process that is regulated by interactions between the developing epithelium and underlying mesenchyme. Studies in transgenic and knockout mouse models demonstrate that normal lung morphogenesis requires coordinated interactions between cells lining the tubules, which end in peripheral saccules, juxtaposed to an extensive network of capillaries...
2018: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/29274743/ankrd11-associated-with-intellectual-disability-and-autism-regulates-dendrite-differentiation-via-the-bdnf-trkb-signaling-pathway
#8
Minhan Ka, Woo-Yang Kim
Haploinsufficiency of ANKRD11 due to deletion or truncation mutations causes KBG syndrome, a rare genetic disorder characterized by intellectual disability, autism spectrum disorder, and craniofacial abnormalities. However, little is known about the neurobiological role of ANKRD11 during brain development. Here we show that ANKRD11 regulates pyramidal neuron migration and dendritic differentiation in the developing moue cerebral cortex. Using an in utero manipulation approach, we found that Ankrd11 knockdown delayed radial migration of cortical neurons...
December 21, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29274553/bisecting-glcnac-restricts-conformations-of-branches-in-model-n-glycans-with-glcnac-termini
#9
Shinya Hanashima, Akitsugu Suga, Yoshiki Yamaguchi
Bisected N-glycans play significant roles in tumor migration and Alzheimer's disease through modulating the action and localization of their carrier proteins. Such biological functions are often discussed in terms of the conformation of the attached N-glycans with or without bisecting GlcNAc. To obtain insights into the effects of bisecting GlcNAc on glycan conformation, a systematic NMR structural analysis was performed on two pairs of synthetic N-glycans, with and without bisecting GlcNAc. The analysis reveals that terminal GlcNAcs and bisecting GlcNAc cooperate to restrict the conformations of both the α1-3 and α1-6 branches of N-glycans...
December 14, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29273858/if-squeezed-a-camel-passes-through-the-eye-of-a-needle-voltage-mediated-stretching-of-dendrimers-facilitates-passage-through-a-nanopore
#10
Alina Asandei, Irina Schiopu, Corina Ciobanasu, Yoonkyung Park, Tudor Luchian
Herein, we report uni-molecular observations of electric potential- and electrolyte-dependent elasticity of poly(amidoamine) (PAMAM)-G1.5 dendrimers containing sodium carboxylate surface groups, using the electric field-assisted migration through the α-hemolysin nanopore (α-HL). Although at moderate transmembrane potentials the dendrimer (~ 2.5 nm in diameter) is sterically excluded from translocation across the constriction region of the nanopore (~ 1.5 nm in diameter), we found a threshold for its translocation that depends on both the electrolyte pH and ionic strength...
December 22, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29260085/migration-of-segmental-arteriolar-fluorescein-staining-peripherally-in-eye-with-idiopathic-recurrent-branch-retinal-arterial-occlusion
#11
Kenichi Kawano, Yasuki Ito, Fuminori Haga, Taichi Tsunekawa, Hiroko Terasaki
Purpose: To report a novel finding in a case of idiopathic recurrent branch retinal arterial occlusions. Observations: We report our findings in a 31-year-old woman with an idiopathic recurrent branch retinal arterial occlusions (BRAOs) who was followed in our clinic for 16 years. Repeated fluorescein angiographies were performed to evaluate the idiopathic recurrent BRAOs. The findings showed multiple segmental arteriolar staining in the fundus. These staining were found at locations with and without branch retinal arterial occlusions...
September 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29246081/uncovered-chimney-stent-graft-for-renal-arteries-with-the-nellix-endovascular-aneurysm-sealing-technique
#12
Luca Garriboli, Antonio Maria Jannello
PURPOSE: To describe the application of uncovered chimney stent grafts with the Nellix endovascular aneurysm sealing technique (ChEVAS) for juxtarenal abdominal aortic aneurysms (JAAAs). CASE REPORT: Two patients with JAAA and multiple comorbidities were considered unfit for open surgery and were selected for an endovascular approach. Fenestrated and branched endografts were too expensive, and a chimney endovascular approach was considered inappropriate for the relatively high incidence of proximal type I endoleak and graft migration...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29238372/transplantation-of-rat-mesenchymal-stem-cells-overexpressing-hypoxia-inducible-factor-2%C3%AE-improves-blood-perfusion-and-arteriogenesis-in-a-rat-hindlimb-ischemia-model
#13
Weifeng Lu, Xiaoli Chen, Yi Si, Shichai Hong, Zhengyu Shi, Weiguo Fu
Mesenchymal stem cells (MSCs) have been increasingly tested in cell-based therapy to treat numerous diseases. Genetic modification to improve MSC behavior may enhance posttransplantation outcome. This study aims to test the potential therapeutic benefits of rat bone marrow MSCs overexpressing hypoxia-inducible factor 2α (rMSCsHIF-2α ) in a rat hindlimb ischemia model. PBS, rMSCs, or rMSCsHIF-2α were injected into rat ischemic hindlimb. Compared with the injection of PBS or rMSCs, transplantation of rMSCsHIF-2α significantly improved blood perfusion, increased the number of vessel branches in the muscle of the ischemic hindlimb, and improved the foot mobility of the ischemic hindlimb (all P < 0...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29232694/hyperbranched-poly-%C3%AF%C2%B5-lysine-substrate-presenting-the-laminin-sequence-yigsr-induces-the-formation-of-spheroids-in-adult-bone-marrow-stem-cells
#14
Valeria Perugini, Steve T Meikle, Anna L Guildford, Matteo Santin
Unlike the fibroblast-like cells formed upon monolayer culture of human mesenchymal stem cells, the natural stem cell niche of the bone marrow and other types of tissues favours the formation of 3-dimensional (3D) cell clusters. The structuring and biological activity of these clusters are regulated by the contacts established by cells with both the basement membrane and neighbour cells and results in their asymmetric division and the consequent maintenance of both a stem population and a committed progeny...
2017: PloS One
https://www.readbyqxmd.com/read/29225873/migration-of-emboli-in-the-retinal-artery-case-report
#15
Alexandr Stepanov, Marketa Machackova, Tereza Rehakova, Nada Jiraskova, Jan Lestak
Branch retinal artery occlusion (BRAO) is a prevalent vascular occlusive disorder of the eye. In transient BRAO, an embolus temporarily blocks the vessel and then moves on resulting in recovery of blood circulation. In this case, we have documented migration of the embolus with recovery of perfusion of the retina and improvement of visual acuity in a patient with transient BRAO. Early diagnosis and fast action are important in the case of patients with retinal artery occlusion.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29212790/the-arp2-3-regulatory-system-and-its-deregulation-in-cancer
#16
REVIEW
Nicolas Molinie, Alexis Gautreau
The Arp2/3 complex is an evolutionary conserved molecular machine that generates branched actin networks. When activated, the Arp2/3 complex contributes the actin branched junction and thus cross-links the polymerizing actin filaments in a network that exerts a pushing force. The different activators initiate branched actin networks at the cytosolic surface of different cellular membranes to promote their protrusion, movement, or scission in cell migration and membrane traffic. Here we review the structure, function, and regulation of all the direct regulators of the Arp2/3 complex that induce or inhibit the initiation of a branched actin network and that controls the stability of its branched junctions...
January 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29211847/changes-in-neuronal-signaling-and-cell-stress-response-pathways-are-associated-with-a-multigenic-response-of-drosophila-melanogaster-to-ddt-selection
#17
Keon Mook Seong, Brad S Coates, Weilin Sun, John M Clark, Barry R Pittendrigh
The adaptation of insect populations to insecticidal control is a continual threat to human health and sustainable agricultural practices, but many complex genomic mechanisms involved in this adaption remain poorly understood. This study applied a systems approach to investigate the interconnections between structural and functional variance in response to dichlorodiphenyltrichloroethane (DDT) within the Drosophila melanogaster strain 91-R. Directional selection in six selective sweeps coincided with constitutive gene expression differences in DDT resistant flies, including the most highly up-regulated transcript, Unc-115b, which plays a central role in axon guidance, and the most highly down-regulated transcript, the angiopoietin-like CG31832, which is involved in directing vascular branching and dendrite outgrowth but likely under trans-regulatory control...
December 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29211753/response-of-pumas-puma-concolor-to-migration-of-their-primary-prey-in-patagonia
#18
Maria L Gelin, Lyn C Branch, Daniel H Thornton, Andrés J Novaro, Matthew J Gould, Anthony Caragiulo
Large-scale ungulate migrations result in changes in prey availability for top predators and, as a consequence, can alter predator behavior. Migration may include entire populations of prey species, but often prey populations exhibit partial migration with some individuals remaining resident and others migrating. Interactions of migratory prey and predators have been documented in North America and some other parts of the world, but are poorly studied in South America. We examined the response of pumas (Puma concolor) to seasonal migration of guanacos (Lama guanicoe) in La Payunia Reserve in northern Patagonia Argentina, which is the site of the longest known ungulate migration in South America...
2017: PloS One
https://www.readbyqxmd.com/read/29183984/unraveling-the-structure-and-chemical-mechanisms-of-highly-oxygenated-intermediates-in-oxidation-of-organic-compounds
#19
Zhandong Wang, Denisia M Popolan-Vaida, Bingjie Chen, Kai Moshammer, Samah Y Mohamed, Heng Wang, Salim Sioud, Misjudeen A Raji, Katharina Kohse-Höinghaus, Nils Hansen, Philippe Dagaut, Stephen R Leone, S Mani Sarathy
Decades of research on the autooxidation of organic compounds have provided fundamental and practical insights into these processes; however, the structure of many key autooxidation intermediates and the reactions leading to their formation still remain unclear. This work provides additional experimental evidence that highly oxygenated intermediates with one or more hydroperoxy groups are prevalent in the autooxidation of various oxygenated (e.g., alcohol, aldehyde, keto compounds, ether, and ester) and nonoxygenated (e...
November 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29180570/perturbation-of-canonical-and-non-canonical-bmp-signaling-affects-migration-polarity-and-dendritogenesis-of-mouse-cortical-neurons
#20
Monika Saxena, Nitin Agnihotri, Jonaki Sen
Bone Morphogenetic Protein (BMP) signaling has been implicated in regulation of patterning of the forebrain and as a regulator of neurogenesis and gliogenesis in the mammalian cortex. However, its role in regulating other aspects of cortical development in vivo remains unexplored. We hypothesized that BMP signaling may regulate additional processes during the development of cortical neurons after observing the presence of active BMP signaling in a spatio-temporally dynamic pattern in the mouse cortex. Our investigation revealed that BMP signaling specifically regulates migration, polarity and the dendritic morphology of upper layer cortical neurons born at E15...
November 27, 2017: Development
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