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https://www.readbyqxmd.com/read/28645554/monocrotophos-an-organophosphorus-insecticide-disrupts-the-expression-of-hpnetrin-and-its-receptor-neogenin-during-early-development-in-the-sea-urchin-hemicentrotus-pulcherrimus
#1
Xiaona Zhang, Lei Xu, Hua Tian, Cuicui Wang, Wei Wang, Shaoguo Ru
Netrins, chemotropic guidance cues, can guide the extension of serotonergic axons by binding to netrin receptors during neural development. However, little is known about whether disruption of netrin signaling is involved in the mechanisms by which organophosphorus pesticides affect serotonergic nervous system (SNS) development. In this study, we evaluated the effects of the pesticide monocrotophos (MCP) on the expression patterns of HpNetrin and its receptor neogenin as well as on the intracellular calcium ion (Ca(2+)) levels in Hemicentrotus pulcherrimus (sea urchin) by exposing fertilized embryos to 0, 0...
June 20, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28640882/quantitation-of-underivatized-branched-chain-amino-acids-in-sport-nutritional-supplements-by-capillary-electrophoresis-with-direct-or-indirect-uv-absorbance-detection
#2
Jun Qiu, Jinhao Wang, Zhongqi Xu, Huiqing Liu, Jie Ren
The branched-chain amino acids (BCAAs) including leucine (Leu), isoleucine (Ile) and valine (Val) play a pivotal role in the human body. Herein, we developed capillary electrophoresis (CE) coupled with conventional UV detector to quantify underivatized BCAAs in two kinds of sport nutritional supplements. For direct UV detection at 195 nm, the BCAAs (Leu, two enantiomers of Ile and Val) were separated in a background electrolyte (BGE) consisting of 40.0 mmol/L sodium tetraborate, and 40.0 mmol/L β-cyclodextrin (β-CD) at pH 10...
2017: PloS One
https://www.readbyqxmd.com/read/28631253/portal-branch-ligation-does-not-counteract-the-inhibiting-effect-of-temsirolimus-on-extrahepatic-colorectal-metastatic-growth
#3
Sebastian Senger, Jens Sperling, Barbara Oberkircher, Martin K Schilling, Otto Kollmar, Michael D Menger, Christian Ziemann
The mTor-inhibitor temsirolimus (TEM) has potent anti-tumor activities on extrahepatic colorectal metastases. Treatment of patients with advanced disease may require portal branch ligation (PBL). While PBL can induce intrahepatic tumor growth, the effect of PBL on extrahepatic metastases under TEM treatment is unknown. Therefore, we analyzed the effects of TEM treatment on extrahepatic metastases during PBL-associated liver regeneration. GFP-transfected CT26.WT colorectal cancer cells were implanted into the dorsal skinfold chamber of BALB/c-mice...
June 19, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28619056/ophthalmic-artery-occlusion-following-neuro-embolization-of-the-external-carotid-artery-a-case-report
#4
Ng Wei Loon, Balwant Singh Gendeh, Rozman Zakaria, Jemaima Che Hamzah, Norshamsiah Md Din
BACKGROUND: Embozene® is a new neuroembolizing microsphere used to reduce intraoperative bleeding for head and neck tumours. We report a case of iatrogenic ophthalmic artery occlusion after Embozene® embolization of the external carotid artery (ECA). CASE PRESENTATION: A 22-year-old African gentleman presented with left nasal obstruction and epistaxis for 2 years and was diagnosed with nasopharyngeal carcinoma. He subsequently underwent embolization of the maxillary branch of the left ECA using Embozene® Microspheres - 250 μm in size before endoscopic tumour excision to reduce intra-operative bleeding...
June 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28618962/amelioration-of-dalton-s-lymphoma-induced-angiogenesis-by-melatonin
#5
Rani Kumari, Kavita Rawat, Anupma Kumari, Anju Shrivastava
For tumor to grow beyond 1-2 mm(3) size, tumor recruits new blood vessels referred as angiogenesis; therefore, targeting angiogenesis can be a promising strategy to suppress cancer progression. In this study, in order to develop a good angiogenesis model, we investigated effect of Dalton's lymphoma on angiogenesis and further monitored the role of melatonin on regulation of angiogenesis. To evaluate angiogenesis, endothelial cells were isolated from main thoracic aorta and cultured in vitro in the presence or absence of Dalton's lymphoma supplemented with or without melatonin to monitor their role on its proliferation and migration, a hallmark of angiogenesis...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28613306/size-tunable-microvortex-capture-of-rare-cells
#6
Reem Khojah, Ryan Stoutamore, Dino Di Carlo
Inertial separation of particles and cells based on their size has advanced significantly over the last decade. However, size-based inertial separation methods require precise tuning of microfluidic device geometries to adjust the separation size of particles or cells. Here, we show a passive capture method that targets a wide size range of cells by controlling the flow conditions in a single device geometry. This multimodal capture device is designed to generate laminar vortices in lateral cavities that branch from long rectangular channels...
June 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28605952/migration-of-contraceptive-implant-into-the-left-pulmonary-arterial-system
#7
Ee Phui Kew, Eshan Senanayake, Madava Djearaman, Ehab Bishay
An 18-year-old woman had an etonogestrel implant inserted into her left upper arm 2 years earlier for menorrhagia. Her symptoms were not well controlled and she requested the implant to be removed. However, clinicians were unable to locate the implant on her left arm. Computed tomography showed that the implant had migrated to a sub-lobar branch of the left lower lobe pulmonary artery. The long-term effect of leaving an etonogestrel implant in the pulmonary arterial system is unknown. This report adds to the small body of evidence on intravascular migration of a subdermally placed contraceptive implant...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28583734/thoracic-endovascular-aortic-repair-with-branched-inoue-stent-graft-for-arch-aortic-aneurysms
#8
Junichi Tazaki, Kanji Inoue, Hirooki Higami, Nobuya Higashitani, Masanao Toma, Naritatsu Saito, Masahide Kawatou, Takeshi Kimura
BACKGROUND: Thoracic endovascular aortic repair (TEVAR) for thoracic aortic aneurysms (TAAs) is in rapid expansion due to its minimal invasiveness. However, TEVAR for an arch aneurysm with a straight stent graft needs surgical reconstruction for supra-aortic vessels. A branched stent graft pioneered by Inoue (branched Inoue Stent Graft [ISG]) has been expected to resolve this problem, but its utility remains to be established in the real clinical setting. This study evaluated the long-term clinical outcome of branched ISGs for TAAs...
June 2, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28570446/vascular-endothelial-growth-factor-induction-of-muscle-derived-stem-cells-enhances-vascular-phenotype-while-preserving-myogenic-potential
#9
Howard D Wang, Qiongyu Guo, Amy Quan, Joseph Lopez, Jose C Alonso-Escalante, Denver M Lough, W P Andrew Lee, Gerald Brandacher, Anand R Kumar
BACKGROUND: Previous work by our group and other laboratories have revealed that muscle-derived stem cells (MDSCs) may contain both myogenic and endothelial progenitors, making MDSCs a promising option for skeletal muscle regeneration. The purpose of this study was to investigate the impact of vascular endothelial growth factor (VEGF) induction on the vascular and myogenic potential of MDSCs. METHODS: Muscle-derived stem cells were isolated from 4- to 8-week-old C57BL/6J mice using a preplate technique and recombinant human VEGFa was used as the induction agent...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28561029/bacterial-rada-is-a-dnab-type-helicase-interacting-with-reca-to-promote-bidirectional-d-loop-extension
#10
Léa Marie, Chiara Rapisarda, Violette Morales, Mathieu Bergé, Thomas Perry, Anne-Lise Soulet, Clémence Gruget, Han Remaut, Rémi Fronzes, Patrice Polard
Homologous recombination (HR) is a central process of genome biology driven by a conserved recombinase, which catalyses the pairing of single-stranded DNA (ssDNA) with double-stranded DNA to generate a D-loop intermediate. Bacterial RadA is a conserved HR effector acting with RecA recombinase to promote ssDNA integration. The mechanism of this RadA-mediated assistance to RecA is unknown. Here, we report functional and structural analyses of RadA from the human pathogen Streptococcus pneumoniae. RadA is found to facilitate RecA-driven ssDNA recombination over long genomic distances during natural transformation...
May 31, 2017: Nature Communications
https://www.readbyqxmd.com/read/28559174/prospective-multicenter-study-of-endovascular-repair-of-aortoiliac-and-iliac-aneurysms-using-the-gore-iliac-branch-endoprosthesis
#11
Darren B Schneider, Jon S Matsumura, Jason T Lee, Brian G Peterson, Rabih A Chaer, Gustavo S Oderich
OBJECTIVE: The GORE EXCLUDER Iliac Branch Endoprosthesis (IBE; W. L. Gore and Associates, Flagstaff, Ariz) is an iliac branch stent graft system designed to preserve internal iliac artery perfusion during endovascular repair of aortoiliac aneurysms (AIAs) and common iliac artery (CIA) aneurysms (CIAAs). We report the 6-month primary end point results of the IBE 12-04 United States pivotal trial for endovascular treatment of AIAs and CIAAs using the IBE device. METHODS: The trial prospectively enrolled 63 patients with AIA or CIAA who underwent implantation of the IBE device at 28 centers in the United States from 2013 to 2015...
May 27, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28534963/n-acetylglucosaminyltransferase-iva-promotes-invasion-of-choriocarcinoma
#12
Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Yoko Sekiya, Yoriko Yamashita, Fumitaka Kikkawa
Gestational trophoblastic neoplasia (GTN) results from the malignant transformation of placental trophoblasts which secrete human chorionic gonadotropin (hCG) as do normal placenta or hydatidiform mole. N-acetylglucosaminyltransferase IV (GnT-IV) is a glycosyltransferase which catalyses the formation of β1,4GlcNAc branches on the mannose core of N-glycans. Previous studies reported that β1,4GlcNAc branches on hCG were detected in GTN but not in normal pregnancy or hydatidiform mole. The aim of the present study was to understand the role of GnT-IVa in choriocarcinoma and find the target proteins for GnT-IVa glycosylation which contribute to the malignancy of choriocarcinoma...
May 23, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28534019/migration-of-a-contraceptive-subdermal-device-into-the-lung
#13
Ji Hui Choi, Ha-Yeon Kim, Sung Soo Lee, SiHyun Cho
A single-rod subdermal contraceptive implant is usually located around the insertion site, has been usually known to migrate within less than 2 cm of the insertion site and the true migration over 2 cm has been rarely reported. We report a case of migrated radiopaque subdermal contraceptive implant into lung in a 37-year-old woman. On conducted chest computed tomography, subdermal contraceptive implant was in subsegmental branch in left posterior basal segment of lung. Removal of subdermal contraceptive implant in left posterior basal segment of lung by mini-thoracotomy was performed by a chest surgeon...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28528944/structure-analysis-of-a-novel-heteroxylan-from-the-stem-of-dendrobium-officinale-and-anti-angiogenesis-activities-of-its-sulfated-derivative
#14
Han Yue, Yanqiu Liu, Huanhuan Qu, Kan Ding
Dendrobium officinale Kimura et Migo (Tie-Pi-Shi-Hu), a precious folk medicine exhibiting multiple bioactivities, including antitumor, immune-enhancing and so on. Although evidences showed polysaccharide is one of the major bioactive substances from this herb, several of them were homogenous with fine structures elucidated. In this study, we showed a novel homogeneous heteroxylan obtained from alkali-extracted crude polysaccharide. It composed of arabinose, xylose, glucose and 4-O-methylglucuronic acid (4-MGA) as well as trace amount of rhamnose and galactose in a ratio of 8...
May 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28526753/altered-feto-placental-vascularization-feto-placental-malperfusion-and-fetal-growth-restriction-in-mice-with-egfl7-loss-of-function
#15
Lauretta A Lacko, Romulo Hurtado, Samantha Hinds, Michael G Poulos, Jason M Butler, Heidi Stuhlmann
EGFL7 is a secreted, angiogenic factor produced by embryonic endothelial cells. To understand its role in placental development, we established a novel Egfl7 knockout mouse. The mutant mice have gross defects in chorioallantoic branching morphogenesis and placental vascular patterning. Microangiography and 3D imaging revealed patchy perfusion of Egfl7(-/-) placentas marked by impeded blood conductance through sites of narrowed vessels. Consistent with poor feto-placental perfusion, Egfl7 knockout resulted in reduced placental weight and fetal growth restriction...
May 19, 2017: Development
https://www.readbyqxmd.com/read/28523566/radial-glia-cells-control-angiogenesis-in-the-developing-cerebral-cortex-through-tgf-%C3%AE-1-signaling
#16
Michele Siqueira, Daniel Francis, Diego Gisbert, Flávia Carvalho Alcantara Gomes, Joice Stipursky
Neuroangiogenesis in the developing central nervous system is controlled by interactions between endothelial cells (ECs) and radial glia (RG) neural stem cells, although RG-derived molecules implicated in these events are not fully known. Here, we investigated the role of RG-secreted TGF-β1, in angiogenesis in the developing cerebral cortex. By isolation of murine microcapillary brain endothelial cells (MBECs), we demonstrate that conditioned medium from RG cultures (RG-CM) promoted MBEC migration and formation of vessel-like structures in vitro, in a TGF-β1-dependent manner...
May 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28521993/chitosan-oligosaccharides-inhibit-epithelial-cell-migration-through-blockade-of-n-acetylglucosaminyltransferase-v-and-branched-glcnac-structure
#17
Qingsong Xu, Wenjing Wang, Chen Qu, Jianguo Gu, Heng Yin, Zhihao Jia, Linsheng Song, Yuguang Du
Chitosan oligosaccharides (COS) have been shown to regulate various cellular and biological functions. The aim of this study was to investigate the antimetastatic potency of COS and the underlying mechanism. Here, we established a stably N-acetylglucosaminyltransferase V (GnT-V)-overexpressed MCF10A cell line. As expected, GnT-V overexpression greatly promoted cell migration in the transfectants by using wound healing assay. However, the induction in the cell migration was significantly suppressed by an addition of COS...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28515858/three-dimensional-optical-coherence-tomography-reconstruction-of-bifurcation-stenting-using-the-szabo-anchor-wire-technique
#18
Katherine Yu, Harkawal Hundal, Todd Zynda, Arnold Seto
Ostial lesions present unique challenges for percutaneous coronary intervention (PCI). These lesions are often more calcified, fibrotic, rigid, and more prone to elastic recoil. Intervention on these lesions is associated with higher procedural complications and higher rates of restenosis. Ostial lesions require precise stent placement in the ostium with the absence of side branch compromise. Accurate stent placement in the ostium without side branch compromise is difficult to accomplish with angiography alone...
April 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28511132/activity-and-in-vivo-dynamics-of-bacillus-subtilis-disa-are-affected-by-rada-sms-and-by-holliday-junction-processing-proteins
#19
Carolina Gándara, Daniella K C de Lucena, Rubén Torres, Ester Serrano, Stephan Altenburger, Peter L Graumann, Juan C Alonso
Bacillus subtilis c-di-AMP synthase DisA and RecA-related RadA/Sms are involved in the repair of DNA damage in exponentially growing cells. We provide genetic evidence that DisA or RadA/Sms is epistatic to the branch migration translocase (BMT) RecG and the Holliday junction (HJ) resolvase RecU in response to DNA damage. We provide genetic evidence damage. Functional DisA-YFP formed dynamic foci in exponentially growing cells, which moved through the nucleoids at a speed compatible with a DNA-scanning mode...
May 5, 2017: DNA Repair
https://www.readbyqxmd.com/read/28506999/btbd7-is-essential-for-region-specific-epithelial-cell-dynamics-and-branching-morphogenesis-in-vivo
#20
William P Daley, Kazue Matsumoto, Andrew D Doyle, Shaohe Wang, Brian J DuChez, Kenn Holmbeck, Kenneth M Yamada
Branching morphogenesis of developing organs requires coordinated but poorly understood changes in epithelial cell-cell adhesion and cell motility. We report that Btbd7 is a crucial regulator of branching morphogenesis in vivo. Btbd7 levels are elevated in peripheral cells of branching epithelial end buds, where it enhances cell motility and cell-cell adhesion dynamics. Genetic ablation of Btbd7 in mice disrupts branching morphogenesis of salivary gland, lung and kidney. Btbd7 knockout results in more tightly packed outer bud cells, which display stronger E-cadherin localization, reduced cell motility and decreased dynamics of transient cell separations associated with cleft formation; inner bud cells remain unaffected...
June 15, 2017: Development
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