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Branch migration

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https://www.readbyqxmd.com/read/28340528/znfe2o4-nanotapers-slag-assistant-growth-and-enhanced-photoelectrochemical-efficiency
#1
Xuefeng She, Zhuo Zhang
In this study, ZnFe2O4 (ZFO) nanotapers are fabricated on the ZnO nanorods (NRs) by recycling rare-earth oxide (REO) slag as the iron source, which thereby exhibits dramatically enhanced photoelectrochemical (PEC) efficiency. Our studies demonstrate that the electron-hole separation and charge migration can be facilitated by the cascade band alignment of ZFO and ZnO and the branched nanotaper structures. Not only the iron source, the slag particles can also act as the passivation layers, leading to improved electron lifetime and significant PEC enhancement...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28337749/branched-i%C3%A2-antigens-on-leukemia-cells-enhanced-sensitivity-against-natural-killer-cell-cytotoxicity-through-affecting-the-target-effector-interaction
#2
Yen-Hua Lee, Yi-Jen Liao, Chin-Han Huang, Fu-Ling Chang, Ting-Hsi Fan, Yuh-Ching Twu
BACKGROUND: The aberrant glycosylation on proteins and lipids has been implicated in malignant transformations for promoting the tumorigenesis, metastasis, and evasion from the host immunity. The I-branching β-1,6-N-acetylglucosaminyltransferase, converting the straight i to branched I histo-blood group antigens, reportedly could influence the migration, invasion, and metastasis of solid tumors. STUDY DESIGN AND METHODS: We first chose the highly cytotoxic natural killer (NK)-92MI cells as effector against leukemia for this cell line has been used in several clinical trials...
March 24, 2017: Transfusion
https://www.readbyqxmd.com/read/28337319/bifunctional-inhibitors-as-a-new-tool-to-reduce-cancer-cell-invasion-by-impairing-mmp-9-homodimerization
#3
Elisa Nuti, Lea Rosalia, Doretta Cuffaro, Caterina Camodeca, Chiara Giacomelli, Eleonora Da Pozzo, Tiziano Tuccinardi, Barbara Costa, Claudia Antoni, Laura Vera, Lidia Ciccone, Elisabetta Orlandini, Susanna Nencetti, Vincent Dive, Claudia Martini, Enrico A Stura, Armando Rossello
Protein homodimers play important roles in physiological and pathological processes, including cancer invasion and metastasis. Recently, MMP-9 natural homodimerization via the PEX domain has been correlated with high migration rates of aggressive cancer cells. Here we propose that bifunctional MMP-9 inhibitors designed to impair natural MMP-9 homodimerization promoted by PEX-PEX interactions might be an effective tool to fight cancer cell invasion. Elaborating a previously described dimeric hydroxamate inhibitor 1, new ligands were synthesized with different linker lengths and branch points...
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28337266/long-non-coding-rna-uca1-promotes-cell-progression-by-acting-as-a-competing-endogenous-rna-of-atf2-in-prostate-cancer
#4
Shilong Zhang, Xinxin Dong, Tongyu Ji, Guoxiao Chen, Lei Shan
Prostate cancer (PCa) is a leading cause of cancer-related deaths in elder men. This disease has limited therapeutic options and poor prognosis as the underlying molecular mechanisms are not clearly understood. LncRNA UCA1 functions as an oncogene in many types of cancers. However, the role of UCA1 in PCa remains unclear. In the present study, we showed that UCA1 was significantly up-regulated in PCa cell lines and tissue samples. High UCA1 expression was positively associated with high gleason score, advanced TNM stage and shorter overall survival of PCa patients...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28334356/transient-cell-intrinsic-activity-regulates-the-migration-and-laminar-positioning-of-cortical-projection-neurons
#5
Nicolas Hurni, Marta Kolodziejczak, Ugo Tomasello, Joan Badia, Moritz Jacobshagen, Julien Prados, Alexandre Dayer
Neocortical microcircuits are built during development and require the coordinated assembly of excitatory glutamatergic projection neurons (PNs) into functional networks. Neuronal migration is an essential step in this process. In addition to cell-intrinsic mechanisms, external cues including neurotransmitters regulate cortical neuron migration, suggesting that early activity could influence this process. Here, we aimed to investigate the role of cell-intrinsic activity in migrating PNs in vivo using a designer receptor exclusively activated by a designer drug (DREADD) chemogenetic approach...
March 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28331069/efficiency-of-lamellipodia-protrusion-is-determined-by-the-extent-of-cytosolic-actin-assembly
#6
Georgi Dimchev, Anika Steffen, Frieda Kage, Vanessa Dimchev, Julien Pernier, Marie-France Carlier, Klemens Rottner
Cell migration and cell-cell communication involves the protrusion of actin-rich cell surface projections such as lamellipodia and filopodia. Lamellipodia are networks of actin filaments generated and turned over by filament branching through Arp2/3 complex. Inhibition of branching is commonly agreed to eliminate formation and maintenance of lamellipodial actin networks, but the regulation of nucleation or elongation of Arp2/3-independent filament populations within the network e.g. by formins or Ena/VASP family members and its impact on the effectivity of protrusion have remained unclear...
March 22, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28327544/fmnl-formins-boost-lamellipodial-force-generation
#7
Frieda Kage, Moritz Winterhoff, Vanessa Dimchev, Jan Mueller, Tobias Thalheim, Anika Freise, Stefan Brühmann, Jana Kollasser, Jennifer Block, Georgi Dimchev, Matthias Geyer, Hans-Joachim Schnittler, Cord Brakebusch, Theresia E B Stradal, Marie-France Carlier, Michael Sixt, Josef Käs, Jan Faix, Klemens Rottner
Migration frequently involves Rac-mediated protrusion of lamellipodia, formed by Arp2/3 complex-dependent branching thought to be crucial for force generation and stability of these networks. The formins FMNL2 and FMNL3 are Cdc42 effectors targeting to the lamellipodium tip and shown here to nucleate and elongate actin filaments with complementary activities in vitro. In migrating B16-F1 melanoma cells, both formins contribute to the velocity of lamellipodium protrusion. Loss of FMNL2/3 function in melanoma cells and fibroblasts reduces lamellipodial width, actin filament density and -bundling, without changing patterns of Arp2/3 complex incorporation...
March 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28319069/the-branched-chain-amino-acid-transaminase-1-sustains-growth-of-antiestrogen-resistant-and-er%C3%AE-negative-breast-cancer
#8
V Thewes, R Simon, M Hlevnjak, M Schlotter, P Schroeter, K Schmidt, Y Wu, T Anzeneder, W Wang, P Windisch, M Kirchgäßner, N Melling, N Kneisel, R Büttner, U Deuschle, H P Sinn, A Schneeweiss, S Heck, S Kaulfuss, H Hess-Stumpp, J G Okun, G Sauter, A E Lykkesfeldt, M Zapatka, B Radlwimmer, P Lichter, M Tönjes
Antiestrogen-resistant and triple-negative breast tumors pose a serious clinical challenge because of limited treatment options. We assessed global gene expression changes in antiestrogen-sensitive compared with antiestrogen-resistant (two tamoxifen resistant and two fulvestrant resistant) MCF-7 breast cancer cell lines. The branched-chain amino acid transaminase 1 (BCAT1), which catalyzes the first step in the breakdown of branched-chain amino acids, was among the most upregulated transcripts in antiestrogen-resistant cells...
March 20, 2017: Oncogene
https://www.readbyqxmd.com/read/28303030/formyl-peptide-receptors-promotes-neural-differentiation-in-mouse-neural-stem-cells-by-ros-generation-and-regulation-of-pi3k-akt-signaling
#9
Liang Zhang, Guan Wang, Xingxing Chen, Xin Xue, Qiaonan Guo, Mingyong Liu, Jianhua Zhao
This study aimed to determine whether formyl peptide receptors (FPRs) regulated the differentiation of neural stem cells (NSCs). FPRs promote the migration of NSCs both in vitro and in vivo. However, the role of FPRs during differentiation of NSCs is unknown. Analysis by Western blot showed significantly increased expression of FPR1 and FPR2 during differentiation of NSCs. The activation of FPRs promotes NSCs to differentiate into neurons with more primary neurites and branch points and longer neurites per cell...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28280571/a-full-lifespan-model-of-vertebrate-lens-growth
#10
Hrvoje Šikić, Yanrong Shi, Snježana Lubura, Steven Bassnett
The mathematical determinants of vertebrate organ growth have yet to be elucidated fully. Here, we utilized empirical measurements and a dynamic branching process-based model to examine the growth of a simple organ system, the mouse lens, from E14.5 until the end of life. Our stochastic model used difference equations to model immigration and emigration between zones of the lens epithelium and included some deterministic elements, such as cellular footprint area. We found that the epithelial cell cycle was shortened significantly in the embryo, facilitating the rapid growth that marks early lens development...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28252672/acute-podocyte-injury-is-not-a-stimulus-for-podocytes-to-migrate-along-the-glomerular-basement-membrane-in-zebrafish-larvae
#11
Florian Siegerist, Antje Blumenthal, Weibin Zhou, Karlhans Endlich, Nicole Endlich
Podocytes have a unique 3D structure of major and interdigitating foot processes which is the prerequisite for renal blood filtration. Loss of podocytes leads to chronic kidney disease ending in end stage renal disease. Until now, the question if podocytes can be replaced by immigration of cells along the glomerular basement membrane (GBM) is under debate. We recently showed that in contrast to former theories, podocytes are stationary in the zebrafish pronephros and neither migrate nor change their branching pattern of major processes over 23 hours...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28238763/structure-and-function-of-a-novel-atpase-that-interacts-with-holliday-junction-resolvase-hjc-and-promotes-branch-migration
#12
Binyuan Zhai, Kevin DuPrez, Tzanko I Doukov, Huan Li, Mengting Huang, Guijun Shang, Jinfeng Ni, Lichuan Gu, Yulong Shen, Li Fan
Holliday junction (HJ) is a hallmark intermediate in DNA recombination and must be processed by dissolution (for double HJ) or resolution to ensure genome stability. Although HJ resolvases have been identified in all domains of life, there is a long-standing effort to search in prokaryotes and eukarya for proteins promoting HJ migration. Here, we report the structural and functional characterization of a novel ATPase, Sulfolobus islandicusPilT N-terminal-domain-containing ATPase (SisPINA), encoded by the gene adjacent to the resolvase Hjc coding gene...
February 24, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28219567/contraceptive-implant-embolism-into-the-pulmonary-artery-thoracoscopic-retrieval
#13
Pascal A Thomas, Donatella Di Stefano, Cécile Couteau, Xavier Benoît D'Journo
An 18-year old woman had migration of a subdermal contraceptive implant in a subsegmental branch of her left lower lobe pulmonary artery. She was managed successfully through a conservative surgical approach, as the implant was removed from the pulmonary artery thoracoscopically, thereby avoiding the need of thoracotomy or lung resection.
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219140/-effects-of-transient-exposure-to-high-glucose-on-biological-behaviors-of-human-dermal-microvascular-endothelial-cells
#14
L Qiao, H Z Yang, X C Li, X Q Huang, B Yuan, Z D Zhou
Objective: To observe the effects of transient exposure to high glucose on biological behaviors of human dermal microvascular endothelial cells cultured in vitro. Methods: The dividing method and treatment of cells for the detection of all indexes in this study were as follows. Human dermal microvascular endothelial cells of the 4th passage were divided into 3 groups according to the random number table, with 12 wells in each group. Cells in control group (C) were cultured with complete culture solution containing 5 mmol/L D-glucose for 7 d...
February 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28214893/the-role-of-netrins-and-their-receptors-in-epithelial-mesenchymal-plasticity-during-development
#15
Michael J Murray
Transitions between mesenchymal and epithelial cells are underpinned by changes in motility, adhesion, and polarity. Netrins and their receptors can control each of these cellular properties, and are emerging as important regulators of epithelial mesenchymal plasticity (EMP). Netrins were first identified in the worm Caenorhabditis elegans as secreted chemoattractants/repellents that could guide migrating mesodermal cells and axonal growth cones. Orthologues were subsequently found to play conserved roles in vertebrates and in the vinegar fly Drosophila...
2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28208423/modeling-angiogenesis-a-discrete-to-continuum-description
#16
Samara Pillay, Helen M Byrne, Philip K Maini
Angiogenesis is the process by which new blood vessels develop from existing vasculature. During angiogenesis, endothelial tip cells migrate via diffusion and chemotaxis, loops form via tip-to-tip and tip-to-sprout anastomosis, new tip cells are produced via branching, and a vessel network forms as endothelial cells follow the paths of tip cells. The latter process is known as the snail trail. We use a mean-field approximation to systematically derive a continuum model from a two-dimensional lattice-based cellular automaton model of angiogenesis in the corneal assay, based on the snail-trail process...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28201758/a-branch-migration-based-fluorescent-probe-for-straightforward-sensitive-and-specific-discrimination-of-dna-mutations
#17
Xianjin Xiao, Tongbo Wu, Lei Xu, Wei Chen, Meiping Zhao
No abstract text is available yet for this article.
February 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28186970/high-expression-of-gfat1-predicts-unfavorable-prognosis-in-patients-with-hepatocellular-carcinoma
#18
Lili Li, Miaomiao Shao, Peike Peng, Caiting Yang, Shushu Song, Fangfang Duan, Dongwei Jia, Mingming Zhang, Junjie Zhao, Ran Zhao, Weicheng Wu, Lan Wang, Can Li, Hao Wu, Jie Zhang, Xin Wu, Yuanyuan Ruan, Jianxin Gu
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. As a branch of glucose metabolism, hexosamine biosynthesis pathway (HBP) has been reported to play a critical role in the insulin resistance and progression of cancer. Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the rate-limiting enzyme of the HBP; nevertheless, the prognostic value of GFAT1 in HCC remains elusive. In this study, we found that high expression of GFAT1 was significantly associated with serum alpha-fetoprotein (AFP), serum alanine aminotransferase (ALT), tumor size, tumor encapsulation, T stage and TNM stage...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28181379/inhibitory-effects-of-leucaena-leucocephala-on-the-metastasis-and-invasion-of-human-oral-cancer-cells
#19
Hsiao-Hang Chung, Mu-Kuan Chen, Yu-Chao Chang, Shun-Fa Yang, Chia-Chieh Lin, Chiao-Wen Lin
Oral cancer is one of the most common cancers worldwide, and metastasis is recognized as a major factor causing its low survival rate. The inhibition of metastasis progress and the improvement of the survival rate for oral cancer are critical research objectives. Leucaena leucocephala from the mimosa branch Leucaena genus is native to Central and South America and has been used as a traditional remedy for treating various disorders. Previous studies have demonstrated antioxidant, anti-inflammatory as well as anticancer properties of L...
February 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28178688/upregulated-wee1-protects-endothelial-cells-of-colorectal-cancer-liver-metastases
#20
Peter J Webster, Anna T Littlejohns, Hannah J Gaunt, Richard S Young, Baptiste Rode, Judith E Ritchie, Lucy F Stead, Sally Harrison, Alastair Droop, Heather L Martin, Darren C Tomlinson, Adam J Hyman, Hollie L Appleby, Sally Boxall, Alexander F Bruns, Jing Li, Raj K Prasad, J Peter A Lodge, Dermot A Burke, David J Beech
Surgical resection of colorectal cancer liver metastases (CLM) can be curative, yet 80% of patients are unsuitable for this treatment. As angiogenesis is a determinant of CLM progression we isolated endothelial cells from CLM and sought a mechanism which is upregulated, essential for angiogenic properties of these cells and relevant to emerging therapeutic options. Matched CLM endothelial cells (CLMECs) and endothelial cells of normal adjacent liver (LiECs) were superficially similar but transcriptome sequencing revealed molecular differences, one of which was unexpected upregulation and functional significance of the checkpoint kinase WEE1...
February 2, 2017: Oncotarget
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