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https://www.readbyqxmd.com/read/29785591/association-of-reduced-sclerostin-expression-with-collapse-process-in-patients-with-osteonecrosis-of-the-femoral-head
#1
Xiao-Jun Chen, Fan Yang, Zhen-Qiu Chen, Min-Cong He, Guo-Ju Hong, Jun-Yuan Huang, Ying-Chun Zhou, Yi-Xian Qin, Qiu-Shi Wei, Wei He
PURPOSE: Sclerostin is an osteocyte-derived protein that has a potent inhibitory effect on osteoblast activity. The osteocyte apoptosis induced by various causes of osteonecrosis of the femoral head (ONFH) plays a key role in the promotion of femoral head collapse. But the effect of altering sclerostin level on the collapse of ONFH has not been studied. Our aim was to assess the role of sclerostin level in the collapse of ONFH. METHODS: Between May 2016 and November 2016, 236 subjects were enrolled in the present study...
May 21, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29775946/il-9-exhibits-elevated-expression-in-osteonecrosis-of-femoral-head-patients-and-promotes-cartilage-degradation-through-activation-of-jak-stat-signaling-in-vitro
#2
Wei Geng, Wen Zhang, Jinzhu Ma
Osteonecrosis of the femoral head (ONFH) often causes severe symptoms in young people and limits the mobility of the hip joint. Interleukin-9 (IL-9) is a multi-functional inflammatory factor that participates in lumbar disk herniation and arthritis and has been reported in many studies. However, the correlation between IL-9 and ONFH is unclear. The present study aimed to determine the role of IL-9 in the pathogenetic mechanism of osteonecrosis. To assess IL-9 expression in ONFH and femoral neck fracture patients, cartilage tissue was examined through western blot analysis and immunohistochemistry...
May 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29761221/interest-of-short-implants-in-hip-arthroplasty-for-osteonecrosis-of-the-femoral-head-comparative-study-uncemented-short-vs-cemented-conventional-femoral-stems
#3
Mehdi Miladi, Benoît Villain, Nasser Mebtouche, Thierry Bégué, Jean-Charles Aurégan
PURPOSES: Osteonecrosis of the femoral head (ONFH) is a dramatic condition resulting in joint destruction in the late stages. Total hip arthroplasty allows function recovery with satisfactory implant survival. Recently, the use of uncemented short stems has been suggested to improve the conservation of bone stock. METHODS: We performed a retrospective study on 16 hip arthroplasties-11 patients-implanted for ONFH between 2008 and 2017. We aimed to compare the outcomes of the two types of arthroplasty-"uncemented short" vs "cemented conventional" femoral stem-in terms of pain (visual analogue scale), function (Harris Hip Score), and survival (radiography)...
May 15, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29758548/stromal-cell-derived-factor-sdf-1-alpha-overexpression-promotes-bone-regeneration-by-osteogenesis-and-angiogenesis-in-osteonecrosis-of-the-femoral-head
#4
Fan Yang, Feng Xue, Junjie Guan, Zeng Zhang, Jimin Yin, Qingling Kang
BACKGROUND/AIMS: Osteonecrosis of the femoral head (ONFH) is a devastating orthopedic disease. Previous studies suggested that stromal-cell-derived factor (SDF)-1 was involved in osteogenesis and angiogenesis. However, whether SDF-1 potentiates the angiogenesis and osteogenesis of bone marrow-derived stromal stem cells (BMSCs) in ONFH is not clear. METHODS: BMSCs were transfected with green fluorescent protein (GFP) or the fusion gene encoding GFP and SDF-1α, and transgenic efficacy was monitored by immunofluorescence...
May 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29754187/nationwide-multicenter-follow-up-cohort-study-of-hip-arthroplasties-performed-for-osteonecrosis-of-the-femoral-head
#5
Seneki Kobayashi, Toshikazu Kubo, Yukihide Iwamoto, Wakaba Fukushima, Nobuhiko Sugano
PURPOSE: To identify modifiable factors related to post-operative dislocation and reoperation in patients with osteonecrosis of the femoral head (ONFH) in a large cohort. METHODS: We studied 4995 hip arthroplasties: total hip arthroplasty (THA) was performed in 79% of patients; bipolar hemiarthroplasty (BP), 17%; total resurfacing arthroplasty (tRS), 3%; and hemi-resurfacing arthroplasty (hRS), 1%. A new type of BP (accounting for 49% of BPs) comprised a femoral component with a polished or smooth, small-diameter (approximately 10 mm) neck with a round or oval axial cut surface and no sharp corners...
May 12, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29728733/what-is-the-rate-of-patients-undergoing-a-total-hip-arthroplasty-after-core-decompression-and-insertion-of-a-tantalum-rod-in-osteonecrosis-of-the-femoral-head-a-systematic-review
#6
Jean-Charles Aurégan, Benoît Villain, Thierry Bégué
PURPOSE: Core decompression (CD) may be effective when performed during the early stages of osteonecrosis of the femoral head (ONFH). Tantalum may be added as a rod that would allow putting some mechanical constraints on the femoral head. We aimed to estimate the rate of total hip arthroplasty after CD and insertion of a tantalum rod during early stages of OFNH. METHODS: We searched systematically Medline via PubMed and the Cochrane Library. Our primary endpoint was the rate of patients undergoing a total hip arthroplasty after CD and insertion of a tantalum rod...
May 4, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29725783/stem-cell-therapy-for-osteonecrosis-of-the-femoral-head-current-trends-and-comprehensive-review
#7
REVIEW
Lei Zhao, Alan David Kaye, Aaron J Kaye, Alaa Abd-Elsayed
PURPOSE OF REVIEW: Osteonecrosis of the femoral head (ONFH) is a common and frequently occurring disease. It is caused by interruption of blood supply with different etiologies. ONFH leads to degeneration and necrosis of the subchondral bone of the femoral head and eventually collapse of the femoral head. ONFH has a high disability rate, seriously affecting the quality of living of patients, and often involves middle-aged and younger people. RECENT FINDINGS: In recent years, the technology and understanding of stem cells and regenerative medicine have been developing rapidly...
May 3, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29705871/mid-term-results-of-concentrated-autologous-bone-marrow-aspirate-transplantation-for-corticosteroid-associated-osteonecrosis-of-the-femoral-head-in-systemic-lupus-erythematosus
#8
Yohei Tomaru, Tomokazu Yoshioka, Hisashi Sugaya, Yukiyo Shimizu, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Masashi Yamazaki, Hajime Mishima
PURPOSE: We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head (ONFH). This study aimed to evaluate the effects of CABMAT as a hip-preserving surgical approach, preventing conversion to total hip arthroplasty (THA) and femoral head collapse in patients with systemic lupus erythematosus (SLE). METHODS: Since 2003, 52 SLE patients (8 male, 44 female, 92 hips, mean age 35...
April 28, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29705870/animal-models-of-steroid-induced-osteonecrosis-of-the-femoral-head-a-comprehensive-research-review-up-to-2018
#9
REVIEW
Jianzhong Xu, Hanpu Gong, Shitao Lu, Matthey J Deasey, Quanjun Cui
Osteonecrosis of the femoral head (ONFH) is a significant cause of both pain and disability that often affects young adults during what ought to be their most productive age. Two broad categories of ONFH exist: traumatic and non-traumatic. Traumatic ONFH results from acute mechanical disruption of the femoral head's blood supply. Many factors that increase the risk of non-traumatic osteonecrosis have been identified. Steroid-induced osteonecrosis of the femoral head (SONFH) is the most common form of non-traumatic ONFH...
April 28, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29704023/radiological-analysis-of-cystic-lesion-in-osteonecrosis-of-the-femoral-head
#10
Fuqiang Gao, Jun Han, Zike He, Zirong Li
PURPOSE: Cystic lesions are a common complication in osteonecrosis of the femoral head (ONFH). This study will discuss the cause of cystic lesion formation and the feature of cystic lesion distribution in ONFH. According to the feature of cystic lesion in ONFH, we will discuss the possible mechanisms of cystic lesions and their  influence on collapse of the femoral head. MATERIALS AND METHODS: We retrospectively gathered 102 ONFH patients (168 hips) from November in 2015 to August in 2016 on China-Japan Friendship Hospital...
April 27, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29700584/microrna-mediated-interacting-circuits-predict-hypoxia-and-inhibited-osteogenesis-of-stem-cells-and-dysregulated-angiogenesis-are-involved-in-osteonecrosis-of-the-femoral-head
#11
Gour-Shenq Kao, Yuan-Kun Tu, Pei-Hsun Sung, Feng-Sheng Wang, Yu-Der Lu, Chen-Ta Wu, Rio L C Lin, Hon-Kan Yip, Mel S Lee
PURPOSE: MicroRNAs (miRNAs) are associated with various pathologic conditions and can serve as diagnostic or therapeutic biomarkers. This study tried to identify the differentially expressed miRNAs to predict the possible pathomechanisms involved in osteonecrosis of the femoral head (ONFH). METHODS: We compared the peripheral blood miRNAs in 46 patients with ONFH and 85 healthy controls by microarray and droplet digital polymerase chain reaction (ddPCR). Putative interacted networks between the differentially responded miRNAs were analyzed by web-based bioinformatics prediction tools...
April 26, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29700582/delay-of-total-hip-arthroplasty-to-advanced-stage-worsens-post-operative-hip-motion-in-patients-with-femoral-head-osteonecrosis
#12
Woo-Lam Jo, Young-Kyun Lee, Yong-Chan Ha, Tae-Young Kim, Kyung-Hoi Koo
PURPOSE: Osteonecrosis of the femoral head (ONFH) is commonly detected in young patients and most surgeons tend to delay total hip arthroplasty (THA) until the end stage of the disease. We hypothesised that post-operative range of motion (ROM) of the hip as well as baseline ROM at the time of surgery decreases with the disease progression. The purpose of this study was to determine whether patients, who were operated at an advanced stage, have pre- and post-operative hip ROM similar to ROM of patients, who were operated at earlier stages...
April 26, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29698301/is-there-an-association-between-borderline-to-mild-dysplasia-and-hip-osteoarthritis-analysis-of-ct-osteoabsorptiometry
#13
Tohru Irie, Daisuke Takahashi, Tsuyoshi Asano, Ryuta Arai, Muhammad Alaa Terkawi, Yoichi M Ito, Norimasa Iwasaki
BACKGROUND: The definitive treatment of borderline-to-mild dysplasia remains controversial. A more comprehensive understanding of the etiology of osteoarthritis (OA) and clarification of any possible association between borderline-to-mild dysplasia and the pathogenesis of OA are essential. QUESTIONS/PURPOSES: (1) Does the distribution of acetabular subchondral bone density increase according to dysplasia severity? (2) Is there an association between borderline-to-mild dysplasia and OA pathogenesis? METHODS: We evaluated bilateral hips of patients with developmental dysplasia of the hip who underwent eccentric rotational acetabular osteotomy (ERAO) for inclusion in the dysplasia group and contralateral hips of patients with unilateral idiopathic osteonecrosis of the femoral head (ONFH) who underwent curved intertrochanteric varus osteotomy (CVO) for the control group...
April 23, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29695195/serum-levels-of-carotenoids-in-patients-with-osteonecrosis-of-the-femoral-head-are-lower-than-in-healthy-community-living-people
#14
Toshiaki Okura, Taisuke Seki, Koji Suzuki, Naoki Ishiguro, Yukiharu Hasegawa
PURPOSE: Oxidative stress is closely associated with the pathogenesis of nontraumatic osteonecrosis of the femoral head (ONFH). This study aimed to determine whether the serum levels of antioxidant nutrients were decreased in patients with ONFH. METHODS: We analyzed the serum levels of antioxidant nutrients in 39 patients with ONFH (ONFH group) and 78 age- and gender-matched healthy people (control group) who voluntarily participated in the Yakumo study, which is a comprehensive health examination program...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29662777/herbal-fufang-xian-ling-gu-bao-prevents-corticosteroid-induced-osteonecrosis-of-the-femoral-head-a-first-multicentre-randomised-double-blind-placebo-controlled-clinical-trial
#15
Zi-Rong Li, Li-Ming Cheng, Kun-Zheng Wang, Nan-Ping Yang, Shu-Hua Yang, Wei He, Yi-Sheng Wang, Zhong-Ming Wang, Pei Yang, Xian-Zhe Liu, Yue-Zhong Luo, Wei Sun, Hai-Tao Wang, Li-Zhen Zheng, Xin-Luan Wang, Ling Qin
Background/Objective: This is a multicentre, randomised, double-blind, placebo-controlled clinical trial to investigate the safety and efficacy of Chinese herbal Fufang Xian Ling Gu Bao (XLGB) with antiadipogenic compounds for the prevention of corticosteroid (CS)-induced osteonecrosis of femoral head (ONFH). Methods: Patients of both genders, aged between 18 and 65 years, with diseases such as systemic lupus erythematosus, nephrosis, dermatosis and rheumatoid arthritis indicated for CS treatment and who did not show magnetic resonance imaging of ONFH at baseline were recruited into the study and then randomised into either XLGB group (n = 129) with daily oral administration of XLGB or placebo group (n = 146)...
January 2018: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29619500/early-stage-osteonecrosis-of-the-femoral-head-where-are-we-and-where-are-we-going-in-year-2018
#16
REVIEW
Eric Larson, Lynne C Jones, Stuart B Goodman, Kyung-Hoi Koo, Quanjun Cui
Osteonecrosis of the femoral head (ONFH) is a devastating condition affecting relatively young patients whereby the femoral head is necrotic, resulting in significant pain, articular surface collapse, and eventual osteoarthritis. This condition has been highly associated with chronic steroid use, alcoholism, and hip trauma, as well as other less common conditions. Without intervention, this condition has a high likelihood of progressing and developing into end-stage osteoarthritis. Unfortunately, ONFH is difficult to diagnose on plain radiographs in the early stages of the disease, and often requires more advanced imaging modalities such as MRI in order to fully assess for early degeneration...
April 4, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29606872/porous-se-sio-2-nanocomposites-protect-the-femoral-head-from-methylprednisolone-induced-osteonecrosis
#17
Guoying Deng, Chenyun Dai, Jinyuan Chen, Anqi Ji, Jingpeng Zhao, Yue Zhai, Yingjie Kang, Xijian Liu, Yin Wang, Qiugen Wang
Background: Methylprednisolone (MPS) is an important drug used in therapy of many diseases. However, osteonecrosis of the femoral head is a serious damage in the MPS treatment. Thus, it is imperative to develop new drugs to prevent the serious side effect of MPS. Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1β and TNF-α...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29594456/combined-pharmacotherapy-for-osteonecrosis-of-the-femoral-head-after-severe-acute-respiratory-syndrome-and-interstitial-pneumonia-two-and-a-half-to-fourteen-year-follow-up
#18
Weiguo Wang, Nianfei Zhang, Wanshou Guo, Fuqiang Gao
PURPOSE: The purpose of this study was to retrospectively analyze the clinical, functional, and radiological outcomes of combined pharmacotherapy to ONFH after high-dose corticosteroid therapy. METHOD: From August 2003 to June 2015, five patients (ten hips) of ONFH in ARCO stage I, after SARS and Interstitial pneumonia, were treated by combined pharmacotherapy. Lipo-prostaglandin E1 10 μg iv Bid × 28 days, enoxaparin 6000 iu H QD × 12 weeks, alendronate sodium tablet 10 mg QD × 1 year...
March 28, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29589087/imbalanced-bone-turnover-markers-and-low-bone-mineral-density-in-patients-with-osteonecrosis-of-the-femoral-head
#19
Lulu Tian, Seung-Hoon Baek, JinAn Jang, Shin-Yoon Kim
PURPOSE: There have been few studies investigating the cumulative effect of individual factors related to bone metabolism on the systemic balance between bone formation and resorption in patients with osteonecrosis of the femoral head (ONFH). We investigated bone mineral density (BMD) of lumbar spine and bone turnover markers that reflect systemic bone metabolism. METHODS: Two-hundred twenty patients with ONFH were matched to 220 healthy subjects according to age, gender, and body mass index...
March 27, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29589085/real-time-computerised-tomography-assisted-porous-tantalum-implant-in-arco-stage-i-ii-non-traumatic-osteonecrosis-of-the-femoral-head-minimum-five-year-follow-up
#20
Ruyin Hu, Pengfei Lei, Bo Li, Hao Liu, Xucheng Yang, Ting Wen, Yihe Hu, Xiaobin Tian
PURPOSES: This study was established to investigate the medium-term clinical effect of real-time CT assisted porous tantalum implant for the treatment of ARCO stage I-II non-traumatic osteonecrosis of the femoral head (ONFH). METHODS: This study comprised 24 ONFH patients (29 hips) who were treated with intra-operative real-time CT accurate rapid positioning assisted drilling decompression, lesion removal and porous tantalum implant. Harris score, VAS score and imaging in pre-operation and follow-up period were recorded...
March 27, 2018: International Orthopaedics
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