keyword
https://read.qxmd.com/read/38491545/m6a-methylation-modification-and-immune-infiltration-analysis-in-osteonecrosis-of-the-femoral-head
#1
JOURNAL ARTICLE
Weihua Fang, Peng Peng, Kun Lin, Fangjun Xiao, Wei He, Mincong He, Qiushi Wei
Osteonecrosis of the femoral head (ONFH) is a elaborate hip disease characterized by collapse of femoral head and osteoarthritis. RNA N6-methyladenosine (m6A) plays a crucial role in a lot of biological processes within eukaryotic cells. However, the role of m6A in the regulation of ONFH remains unclear. In this study, we identified the m6A regulators in ONFH and performed subtype classification. We identified 7 significantly differentially expressed m6A regulators through the analysis of differences between ONFH and normal samples in the Gene Expression Omnibus (GEO) database...
March 15, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38476629/human-umbilical-cord-mesenchymal-stem-cells-protect-mc3t3-e1-osteoblasts-from-dexamethasone-induced-apoptosis-via-induction-of-the-nrf2-are-signaling-pathway
#2
JOURNAL ARTICLE
Chen Qiu, Zhaowen Li, Puji Peng
OBJECTIVE: To investigate the protective effect human umbilical cord mesenchymal stem cells (hUC-MSCs) have on Dexamethasone (Dex)-induced apoptosis in osteogenesis via the Nrf2-ARE signaling pathway. METHODS: Glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH) was developed in rats through the administration of lipopolysaccharide and methylprednisolone. The incidence of femoral head necrosis, cavity notch, apoptosis of osteoblasts, and bone density were observed by HE staining, TUNEL staining, and Micro-CT...
December 2024: Regenerative Therapy
https://read.qxmd.com/read/38449033/comparison-of-outcomes-after-total-hip-arthroplasty-between-patients-with-osteonecrosis-of-the-femoral-head-in-association-research-circulation-osseous-stage-iii-and-stage-iv-a-five-year-follow-up-study
#3
JOURNAL ARTICLE
Tianyu Wang, Dongwei Wu, Chengsi Li, Xinqun Cheng, Zhenbang Yang, Yingze Zhang, Yanbin Zhu
BACKGROUND: No large cohort study has evaluated the surgical outcomes of THA between different stages of ONFH patients. This study aimed to compare the surgical outcomes of ONFH patients who underwent THA in ARCO stage III versus IV, in terms of operative parameters, one-year hip function assessments and postoperative at least five-year complications, to inform optimized management of ONFH. METHOD: From our prospectively collected database, 876 patients undergoing THA between October 2014 and April 2017 were analyzed and divided into ARCO stage III group (n = 383) and ARCO stage IV group(n = 493)...
March 6, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38439044/total-hip-arthroplasty-after-failed-transtrochanteric-rotational-osteotomy-for-osteonecrosis-of-the-femoral-head-analysis-of-three-dimensional-morphological-features
#4
JOURNAL ARTICLE
Masamichi Onaga, Satoshi Nakasone, Masato Ishihara, Takahiro Igei, Fumiyuki Washizaki, Sakura Kuniyoshi, Kotaro Nishida
BACKGROUND: In total hip arthroplasty (THA) after failed transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head (ONFH), deformity of the proximal femur has been reported to affect stem placement. The aims of this study were to evaluate the morphological changes in the proximal femur, muscle atrophy, and soft tissue thickening in THA after TRO and the clinical outcomes. METHODS: The TRO group included 17 patients (18 hips) who underwent THA after failed TRO...
March 4, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38431280/investigational-regenerative-medicine-for-non-traumatic-osteonecrosis-of-the-femoral-head-a-survey-of-registered-clinical-trials
#5
REVIEW
Yutaka Kuroda, Toshiyuki Kawai, Yaichiro Okuzu, Yugo Morita, Shuichi Matsuda
INTRODUCTION: Osteonecrosis of the femoral head (ONFH) is arefractory disease requiring joint replacement in young patients. Regenerativetherapies have been developed. AREAS COVERED: This study surveyed clinical trials onregenerative medicine for ONFH. We extractedclinical trials on non-traumatic ONFH from the websites of five publiclyavailable major registries (EuropeanUnion Clinical Trials Register ([EU-CTR],ClinicalTrials.gov, Chinese ClinicalTrial Registry [ChiCTR], University Hospital Medical InformationNetwork - Clinical Trial Registry [UMIN-CTR] and Australian New Zealand Clinical Trials Registry [ANZCTR])...
March 2, 2024: Expert Opinion on Investigational Drugs
https://read.qxmd.com/read/38430380/subtracting-adding-strategy-for-necrotic-lesion-segmentation-in-osteonecrosis-of-the-femoral-head
#6
JOURNAL ARTICLE
Jiping Zhang, Sijia Guo, Degang Yu, Cheng-Kung Cheng
PURPOSE: Osteonecrosis of the femoral head (ONFH) is a severe bone disease that can progressively lead to hip dysfunction. Accurately segmenting the necrotic lesion helps in diagnosing and treating ONFH. This paper aims at enhancing deep learning models for necrosis segmentation. METHODS: Necrotic lesions of ONFH are confined to the femoral head. Considering this domain knowledge, we introduce a preprocessing procedure, termed the "subtracting-adding" strategy, which explicitly incorporates this domain knowledge into the downstream deep neural network input...
March 2, 2024: International Journal of Computer Assisted Radiology and Surgery
https://read.qxmd.com/read/38429811/correlation-of-serum-and-local-cxcl13-levels-with-disease-severity-in-patients-with-non-traumatic-osteonecrosis-of-femoral-head
#7
JOURNAL ARTICLE
Yong-Heng Zhao, Wen-Xiu Zhu, Qing-He Ye, Peng Zhang, Biao-Fang Wei
OBJECTIVE: The primary aim of the present study was to explore the potential correlation of serum / local CXCL13 expressions and disease severity in non-traumatic osteonecrosis of the femoral head (NT-ONFH). METHODS: In total, NT-ONFH patients (n = 130) together with healthy controls (HCs, n = 130) were included in this investigation. Radiographic progression was evaluated based on the imaging criteria outlined in the ARCO classification system...
March 1, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38416186/what-are-the-differences-in-the-recovery-of-physical-function-and-clinical-score-between-patients-with-steroid-related-osteonecrosis-of-the-femoral-head-and-hip-osteoarthritis-undergoing-total-hip-arthroplasty-a-propensity-score-matched-study
#8
JOURNAL ARTICLE
Ryota Hamada, Takumi Kawano, Masanobu Murao, Manabu Nankaku, Yaichiro Okuzu, Toshiyuki Kawai, Yutaka Kuroda, Ryosuke Ikeguchi, Shuichi Matsuda
PURPOSE: Steroid-related osteonecrosis of the femoral head (ONFH), arising from steroid administration for underlying diseases, represents a unique pathology for total hip arthroplasty (THA) and typically affects a younger demographic compared to osteoarthritis (OA). Given the significant age-related differences, this study aims to employ propensity score matching to align patient backgrounds between these two diseases and compare physical function. Additionally, our objective is to scrutinize the patterns of clinical score recovery over the course of one year following THA...
February 28, 2024: International Orthopaedics
https://read.qxmd.com/read/38382305/automatic-planning-and-geometric-analysis-of-the-drilling-path-in-core-decompression-surgery-for-osteonecrosis-of-the-femoral-head
#9
JOURNAL ARTICLE
Jiping Zhang, Sijia Guo, Mingzhu Tao, Degang Yu, Cheng-Kung Cheng
BACKGROUND AND OBJECTIVE: Core decompression surgery is an effective treatment method for patients with pre-collapse osteonecrosis of the femoral head (ONFH). The treatment relies on accurately predrilling the wire into the necrotic lesion. However, the surgical planning of this drilling path remains unclear. This paper aims to develop a framework to automatically plan the drilling path and analyze its geometric parameters. METHODOLOGY: The proposed system consists of two stages...
February 8, 2024: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/38376531/evaluation-of-the-long-term-patient-reported-outcomes-after-hip-arthroplasty-or-joint-preserving-with-sugioka-femoral-osteotomy-in-patients-with-femoral-head-osteonecrosis
#10
JOURNAL ARTICLE
Takeshi Shoji, Hideki Shozen, Shinichi Ueki, Hiroki Kaneta, Yuji Yaunaga, Nobuo Adachi
PURPOSE: This study retrospectively evaluated long-term clinical outcomes and patient-reported outcome measures (PROMs) in patients with osteonecrosis of the femoral head (ONFH) who underwent transtrochanteric rotational osteotomy (TRO), curved varus osteotomy (CVO), and total hip arthroplasty (THA). METHODS: We retrospectively reviewed the 109 hips in 96 patients (46 men, 50 women) who underwent CVO, TRO, or THA for ONFH treatment. The mean follow-up period for the TRO, CVO, and THA groups was 14...
February 20, 2024: International Orthopaedics
https://read.qxmd.com/read/38374383/the-efficacy-of-denosumab-in-the-treatment-of-femoral-head-osteonecrosis-a-retrospective-comparative-study
#11
JOURNAL ARTICLE
Jun-Ki Moon, Jinyong Park, Yisack Yoo, Jae Youn Yoon, Sunhyung Lee, Pil Whan Yoon
The present study aimed to compare clinical and radiological differences of ONFH patients who were treated with denosumab, and a control group. A total of 178 patients (272 hips) with symptomatic, nontraumatic ONFH were divided into a denosumab group (98 patients, 146 hips) and a control group (80 patients, 126 hips). Patients in the denosumab group received a 60 mg subcutaneous dose of denosumab every 6 months. For the clinical assessments, Harris hip scores (HHS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were evaluated...
February 20, 2024: Scientific Reports
https://read.qxmd.com/read/38372559/risk-factors-portending-a-total-hip-arthroplasty-for-patients-who-have-osteonecrosis-of-the-femoral-head
#12
JOURNAL ARTICLE
Zhongming Chen, Jeremy A Dubin, Sandeep S Bains, Daniel Hameed, Mallory C Moore, Ronald E Delanois, Michael A Mont, James Nace
INTRODUCTION: Osteonecrosis of the femoral head (ONFH) poses a substantial burden to orthopaedic surgeons. However, the exact risk attributed by each specific patient factor for those who end up receiving a total hip arthroplasty (THA) are not well known. We assessed: (1) patient demographics (age and sex); (2) blood cell dyscrasias (sickle-cell disease and hypercoagulable states); and (3) substance use (oral corticosteroid use, tobacco use, and alcohol abuse). MATERIALS AND METHODS: A retrospective search examined all patients who had a primary THA (n=715,100) between January 1, 2010 and April 30, 2020 using a national, all-payer database...
February 13, 2024: Surgical Technology International
https://read.qxmd.com/read/38371173/detection-of-hiv-1-dna-rna-in-peripheral-blood-bone-marrow-and-femoral-head-of-patients-with-osteonecrosis-of-the-femoral-head
#13
JOURNAL ARTICLE
Kangpeng Li, Bo Liu, Rui Ma, Qiang Zhang
BACKGROUND: With the increasing life expectancy of people living with HIV (PLWH) following antiretroviral therapy (ART), there is a growing prevalence of chronic diseases such as osteonecrosis of the femoral head (ONFH). Compared with the more accessible blood, the viral infection profile in bone marrow and necrotic femoral heads in PLWH remains inadequately characterized. METHODS: Femoral head and bone marrow were collected from 15 PLWH undergoing total hip arthroplasty...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38337011/cellular-senescence-is-associated-with-osteonecrosis-of-the-femoral-head-while-mesenchymal-stem-cell-conditioned-medium-inhibits-bone-collapse
#14
JOURNAL ARTICLE
Masanori Okamoto, Hiroaki Nakashima, Kiyoshi Sakai, Yasuhiko Takegami, Yusuke Osawa, Junna Watanabe, Sadayuki Ito, Hideharu Hibi, Shiro Imagama
Osteonecrosis of the femoral head (ONFH) is a type of ischemic osteonecrosis that causes pain, loss of function, and femoral head collapse. Here, we analyzed samples of femoral heads excised from patients with ONFH to clarify the relationship between ischemic osteonecrosis and cellular senescence. X-gal staining was strong and p16INK4a-positive cells were abundant in the transitional region of ONFH. The β-galactosidase-positive cells in the transitional region were also positive for nestin, periostin, or DMP-1...
February 9, 2024: Scientific Reports
https://read.qxmd.com/read/38322788/partial-femoral-head-replacement-a-new-innovative-hip-preserving-approach-for-treating-osteonecrosis-of-the-femoral-head-and-its-finite-element-analysis
#15
JOURNAL ARTICLE
Yanjiang Yang, Xiaodong Cheng, Wei Chen, Guimiao Li, Yuchuan Wang, Weiyi Sun, Wen An, Qi Zhang, Yingze Zhang
Purpose: Controversy remains regarding the optimal treatment for stage III Osteonecrosis of the femoral head (ONFH). This study presents, for the first time, the precise treatment of stage III ONFH using the "substitute the beam for a pillar" technique and performs a comparative finite element analysis with other hip-preserving procedures. Methods: A formalin-preserved femur of male cadavers was selected to obtain the CT scan data of femur. The proximal femur model was reconstructed and assembled using Mimics 20...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38317366/-the-detecting-value-of-virtual-non-calcium-technique-of-dual-energy-ct-for-bone-marrow-edema-around-nontraumatic-osteonecrosis-of-the-femoral-head
#16
JOURNAL ARTICLE
S H Yang, T R Li, J Lu, Y B Wu, P J Zhang, L T Shang, Y Zhong, B T Yang
Objective: To evaluate the value of virtual non-calcium (VNCa) technique of dual-energy CT (DECT) for detecting bone marrow edema (BME) around nontraumatic osteonecrosis of the femoral head (ONFH) using MRI as reference standard. Methods: Nontraumatic ONFH patients were prospectively studied in the Fourth Medical Center of Chinese PLA General Hospital from October 2022 to May 2023, and their MRI and DECT images were analyzed. The diagnostic efficiency of the subjective assessment of BME around ONFH by two radiologists in VNCa color-coded images were calculated using the MRI results as the reference standard...
February 20, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38309414/anti-sclerostin-antibody-therapy-prevents-post-ischemic-osteonecrosis-bone-collapse-via-interleukin-6-association
#17
JOURNAL ARTICLE
Yuto Ozawa, Yasuhiro Takegami, Yusuke Osawa, Takamune Asamoto, Shinya Tanaka, Shiro Imagama
Osteonecrosis of the femoral head (ONFH) is a debilitating condition characterized by subchondral bone necrosis, which frequently culminates in joint destruction. Although total hip arthroplasty is conventionally practiced to remediate ONFH, for patients under the age of 60, the outcomes can be suboptimal. Chronic inflammation, particularly that mediated by interleukin-6 (IL-6), has been conjectured to be a potential mechanism underlying the etiology of ONFH. This study aimed at exploring the interplay between IL-6, the canonical Wnt signaling pathway, and ONFH to provide insights for potential therapeutic interventions...
February 1, 2024: Bone
https://read.qxmd.com/read/38296807/analysis-of-the-potential-angiogenic-mechanisms-of-bushenhuoxue-decoction-against-osteonecrosis-of-the-femoral-head-based-on-network-pharmacology-and-experimental-validation
#18
JOURNAL ARTICLE
Di Luo, Hao Liu, Xue-Zhen Liang, Wei Yan, Chou Ding, Cheng-Bo Hu, De-Zhi Yan, Jin-Song Li, Ji-Biao Wu
OBJECTIVE: Osteonecrosis of the femoral head (ONFH) is a common orthopedic disease with a high disability rate. The clinical effect of BuShenHuoXue decoction (BSHX) for ONFH is satisfactory. We aimed to elucidate the potential angiogenic mechanisms of BSHX in a rat femoral osteonecrosis model and bone marrow mesenchymal stem cells (BMSCs). METHODS: With in vivo experiments, we established the steroid-induced osteonecrosis of the femoral head (SONFH) model using Sprague-Dawley (SD) rats (8-week-old)...
January 31, 2024: Orthopaedic Surgery
https://read.qxmd.com/read/38278996/cortistatin-prevents-glucocorticoid-associated-osteonecrosis-of-the-femoral-head-via-the-ghsr1a-akt-pathway
#19
JOURNAL ARTICLE
Yuan Gao, Yunhao You, Pengfei Zhang, Yang Yu, Zhaoning Xu, Hui Wei, Zhicheng Liu, Ruixuan Yu, Gaoxin Jin, Hao Wang, Shuai Zhang, Yuhua Li, Weiwei Li
Long-term use of glucocorticoids (GCs) is known to be a predominant cause of osteonecrosis of the femoral head (ONFH). Moreover, GCs can mediate apoptosis of various cell types by exaggerating oxidative stress. We have previously found that Cortistatin (CST) antagonizes oxidative stress and improves cell apoptosis in several conditions. In this study, we detected that the CST expression levels were diminished in patients with ONFH compared with femoral neck fracture (FNF). In addition, a GC-induced rat ONFH model was established, which impaired bone quality in the femoral head...
January 26, 2024: Communications Biology
https://read.qxmd.com/read/38275745/insight-into-steroid-induced-onfh-the-molecular-mechanism-and-function-of-epigenetic-modification-in-mesenchymal-stem-cells
#20
REVIEW
Chengxiong Huang, Liming Qing, Yu Xiao, Juyu Tang, Panfeng Wu
Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease, which is one of the common causes of hip pain and dysfunction. ONFH has a very high disability rate, which is associated with a heavy burden to patients, families, and society. The pathogenesis of ONFH is not completely clear. At present, it is believed that it mainly includes coagulation dysfunction, abnormal lipid metabolism, an imbalance of osteogenic/adipogenic differentiation, and poor vascularization repair. The prevention and treatment of ONFH has always been a great challenge for clinical orthopedic surgeons...
December 20, 2023: Biomolecules
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