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https://www.readbyqxmd.com/read/29154968/non-traumatic-osteonecrosis-of-the-femoral-head-is-associated-with-low-bone-mass
#1
Valérie Gangji, Muhammad S Soyfoo, Audrey Heuschling, Violaine Afzali, Rodrigo Moreno-Reyes, Joanne Rasschaert, Céline Gillet, Jean-Francois Fils, Jean-Philippe Hauzeur
OBJECTIVE: Osteoporosis (OP) and osteonecrosis of the femoral head (ONFH) share common clinical and pathophysiological features we sought to determine whether ONFH was associated with an increased prevalence of OP and whether the increased prevalence of OP was related to the stage of ONFH at diagnosis. METHODS: We included 243 patients with ONFH and 399 age and sex-matched healthy controls. Data was gathered including demography, risk factors, ARCO staging of ONFH and bone mineral density (BMD)...
November 14, 2017: Bone
https://www.readbyqxmd.com/read/29151233/clinical-results-of-hemiarthroplasty-using-new-bipolar-cups-for-stage-3-or-lower-osteonecrosis-of-the-femoral-head-a-retrospective-study
#2
T Abe, N Kaku, T Tabata, H Tagomori, H Tsumura
PURPOSE: The aim of this study was to evaluate clinical and radiographic findings of stage 3 or lower osteonecrosis of the femoral head (ONFH) with intact acetabular cartilage in patients treated with bipolar hemiarthroplasty (BHA). METHODS: A total of 79 hips that underwent BHA for ONFH were included in this study. The average observation period was 7.6 years. Clinical results were evaluated using the Harris hip score. We performed radiographic analysis to assess the migration of the outer cup, the permanent image around the outer cup, and loosening of the stem...
November 18, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29137306/mmp9-polymorphism-is-associated-with-susceptibility-to-non-traumatic-osteonecrosis-of-femoral-head-in-a-chinese-han-population
#3
Yuan Liu, Yanfei Jia, Yuju Cao, Yan Zhao, Jieli Du, Feimeng An, Yuxin Qi, Xue Feng, Tianbo Jin, Jianping Shi, Jianzhong Wang
Non-traumatic osteonecrosis of femoral head (ONFH) is an orthopedic refractory disease with escalating morbidity in Chinese Han population. In our case-control study, we examined eight previously identified MMP9 single-nucleotide polymorphisms (SNPs) in 585 non-traumatic ONFH patients and 507 healthy individuals from northern China to determine whether these SNPs associated with the risk of developing non-traumatic ONFH. Genetic model and haplotype analyses were used to evaluate the association between SNPs and non-traumatic ONFH...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136757/muscone-exerts-protective-roles-on-alcohol-induced-osteonecrosis-of-the-femoral-head
#4
Yan-Jie Guo, Shi-Hua Luo, Ming-Jie Tang, Zu-Bin Zhou, Jun-Hui Yin, You-Shui Gao, Xiao-Qian Dang
Long-term alcohol abuse causes musculoskeletal disorders, among of which, alcohol-induced osteonecrosis of the femoral head (ONFH) is of concern due to its significant and severe complications. A variety of methods have been attempted to prevent alcohol-induced ONFH, and monomers extracted from Chinese herbs might benefit the disease profoundly. In the current study, muscone, the main ingredient of musk, was used to prevent alcohol-induced ONFH. In vitro, ethanol was used to affect the potential of osteogenesis and proliferation of human bone mesenchymal stem cells (hBMSCs), and beneficial role of muscone was investigated on hBMSCs...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136173/high-levels-of-gsk-3%C3%AE-signaling-reduce-osteogenic-differentiation-of-stem-cells-in-osteonecrosis-of-femoral-head
#5
Lu Huang, Ying Wang, Yangzi Jiang, Yan Wu, Changchang Hu, Hongwei Ouyang
Osteonecrosis of the femoral head (ONFH) is a common but intractable disease. In this study, we investigated the mechanisms regulating alterations in mesenchymal stem cell (MSC) differentiation in ONFH. Five patients who were diagnosed with ONFH were enrolled in this study. BMSCs were isolated from the osteonecrotic zone in the femoral head (FH-pMSCs) and from the normal zone in the pelvis (hMSCs) of the same patient. Morphology, cell proliferation, and expression of mediators of the Wnt signaling pathway were evaluated...
November 10, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29131454/emerging-roles-of-micrornas-in-osteonecrosis-of-the-femoral-head
#6
REVIEW
Zheng Li, Bo Yang, Xisheng Weng, Gary Tse, Matthew T V Chan, William Ka Kei Wu
Osteonecrosis of the femoral head (ONFH) is one of the most common orthopaedic diseases. The exact pathogenic mechanism of ONFH is still unknown. MicroRNAs (miRNAs) are a class of non-coding RNAs that negatively modulate gene expression at post-transcriptional level. An increasing number of studies have shown that miRNAs play crucial roles in different physiological processes, including development, cell proliferation, differentiation and metabolism. Recently, multiple studies demonstrated that miRNAs are involved in the pathogenesis of ONFH...
November 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29120670/correlation-between-steroid-induced-osteonecrosis-of-the-femoral-head-and-hepatic-cyp3a-activity-a-systematic-review-and-meta-analysis
#7
Fa-Qi Guo, Min Deng
BACKGROUND: Steroid-induced osteonecrosis of the femoral head (ONFH) in young adults is a challenging disorder that can impairs the quality of life of a patient. The disease also leads to frequent occurrences of collapse of the femoral head and resultant dysfunction of the hip joint. In recent years, some scholars have studied steroid-induced lipid metabolism disorder and achieved the effect of steroid-induced ONFH treatment. This study aims to review the investigations on the hepatic CYP3A (cytochrome P4503A enzyme) genetic polymorphisms in steroid-induced ONFH patients...
November 9, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29089773/a-12-year-follow-up-study-of-combined-treatment-of-post-severe-acute-respiratory-syndrome-patients-with-femoral-head-necrosis
#8
Tiansheng Liu, Jinchao Ma, Bin Su, Hao Wang, Qi Wang, Xinlong Ma
OBJECTIVE: To investigate the long-term efficacy of a combination treatment of alendronate, extracorporeal shock and hyperbaric oxygen for osteonecrosis of the femoral head (ONFH) of post-severe acute respiratory syndrome (SARS) patients. PATIENTS AND METHODS: The retrospective study was performed including a total of 37 post-SARS ONFH patients (66 hip joints) in the Department of Orthopedics of the General Hospital of Tianjin Medical University between November 2003 and November 2015, consisting of 6 males (11 hip joints) and 31 females (55 hip joints), with age between 19 and 47 years (average 29...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29069795/variants-of-gsk3%C3%AE-and-sfrp4-genes-in-wnt-signaling-were-not-associated-with-osteonecrosis-of-the-femoral-head
#9
Yang Song, Zhenwu Du, Qiwei Yang, Ming Ren, Qingyu Wang, Gaoyang Chen, Haiyue Zhao, Zhaoyan Li, Guizhen Zhang
Genome-wide association studies have identified that the gene variants in Wnt signaling associate with bone mineral density and fracture risk but the effects of the variants on the development of osteonecrosis of the femoral head (ONFH) have been unclear. Here, we analyzed the polymorphisms of 4 variants in GSK3β and SFRP4 genes of Wnt signaling and their association with the development of ONFH through Mass ARRAY(®) platform in 200 ONFH patients and 177controls in Chinese population. Our results showed that the genotypes and allele frequencies of all variants detected in SFRP4 and GSK3β genes were not significantly different between patients and controls (p > 0...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29067959/corticosteroid-induced-osteonecrosis-of-the-femoral-head-detection-diagnosis-and-treatment-in-earlier-stages
#10
REVIEW
Li-Hua Liu, Qing-Yu Zhang, Wei Sun, Zi-Rong Li, Fu-Qiang Gao
OBJECTIVE: This review aimed to provide a current recommendation to multidisciplinary physicians for early detection, diagnosis, and treatment of corticosteroid-induced osteonecrosis of the femoral head (ONFH) based on a comprehensive analysis of the clinical literature. DATA SOURCES: For the purpose of collecting potentially eligible articles, we searched for articles in the PubMed, Cochrane Library, Embase, and CNKI databases up to February 2017, using the following key words: "corticosteroid", "osteonecrosis of the femoral head", "risk factors", "diagnosis", "prognosis", and "treatment"...
November 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29049204/the-genetic-association-between-pon1-polymorphisms-and-osteonecrosis-of-femoral-head-a-case-control-study
#11
Jian-Mei Li, Yi Li, Lu Wang
The purpose of this study was to investigate the relationship between Paraoxonase-1 (PON1) gene rs662, rs854555 polymorphisms and osteonecrosis of the femoral head (ONFH) in Han population, northern China.Polymerase chain reaction-restriction fragment length polymorphism was used to determine genotypes of PON1 polymorphisms in 84 patients with ONFH and 96 healthy persons. χ test was used to compare distribution differences of genotype, allele, and haplotype between the case and control groups. The odds ratio (OR) and 95% confidence interval (CI) were calculated to reveal the effects of PON1 polymorphisms on risk of ONFH, and the results were adjusted using logistic regression analysis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049169/association-between-plasminogen-activator-inhibitor-gene-polymorphisms-and-osteonecrosis-of-the-femoral-head-susceptibility-a-case-control-study
#12
Yi Li, Feng-Xia Liu, Chao Yuan, Lingguo Meng
This study aimed to analyze the correlation of the plasminogen activator inhibitor (PAI-1) gene polymorphisms (rs6092 and rs7242) with susceptibility of osteonecrosis of the femoral head (ONFH).This case-control study included 106 ONFH patients and 151 healthy controls. PAI-1 polymorphisms were genotyped by polymerase chain reaction (PCR) with direct sequencing. The genotype distribution of polymorphism in the control group was checked with the status of Hardy-Weinberg equilibrium (HWE). The χ test was applied to compare the genotypes of polymorphisms between the case and control groups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29045937/adenovirus-mediated-expression-of-bmp-2-and-bfgf-in-bone-marrow-mesenchymal-stem-cells-combined-with-demineralized-bone-matrix-for-repair-of-femoral-head-osteonecrosis-in-beagle-dogs
#13
Wu-Xun Peng, Lei Wang
BACKGROUND: This study investigated the effect of using adenovirus-mediated expression of bone morphogenetic protein 2 (Ad-BMP-2) and basic fibroblast growth factor (bFGF) in bone marrow mesenchymal stem cells (BMSCs) in combination with a demineralized bone matrix (DBM) to repair osteonecrosis of the femoral head (ONFH) in Beagle dogs. METHODS: A total of 30 Beagle dogs were selected for the isolation of BMSCs, which were cultured and transfected with the recombinant adenovirus vector Ad-BMP2-bFGF-GFP (carrying BMP-2 and bFGF) or a control adenovirus plasmid (encoding green fluorescent protein (Ad-GFP))...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29042814/attenuated-serum-adiponectin-levels-are-associated-with-disease-severity-in-patients-with-non-traumatic-osteonecrosis-of-the-femoral-head
#14
Yong-Bin Yue, Xin Liu, Biao-Fang Wei
OBJECTIVE: Decreased adiponectin (APN) levels have been detected in patients with osteonecrosis of the femoral head (ONFH). The scope of this study was aimed to explore the relationship between serum APN levels and disease severity in nontraumatic ONFH patients. PATIENTS AND METHODS: Ninety two nontraumatic ONFH patients and 92 healthy controls were enrolled for this study following the estimation of sample size. Serum APN concentrations were examined by enzyme-linked immunosorbent assay (ELISA)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29042586/bone-microarchitecture-and-biomechanics-of-the-necrotic-femoral-head
#15
Jian-Xiong Ma, Wei-Wei He, Jie Zhao, Ming-Jie Kuang, Hao-Hao Bai, Lei Sun, Bin Lu, Ai-Xian Tian, Ying Wang, Ben-Chao Dong, Yan Wang, Xin-Long Ma
The mechanism behind osteonecrosis of the femoral head (ONFH) remains unclear. The aim of this study was to explore the pathogenesis of ONFH from a biomechanical standpoint to provide a theoretical basis for improved treatments. We compared the bone structure of fractured femoral heads with that of necrotic femoral heads by Micro-CT scanning and histological evaluation. In addition, we compared the biomechanical properties of each zone in fractured femoral heads with those in necrotic femoral heads by using biomechanical tests...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29039481/administration-of-erythropoietin-prevents-bone-loss-in-osteonecrosis-of-the-femoral-head-in-mice
#16
Taotao Xu, Hongting Jin, Yangjun Lao, Pinger Wang, Shanxing Zhang, Hongfeng Ruan, Qiang Mao, Li Zhou, Luwei Xiao, Peijian Tong, Chengliang Wu
Long‑term administration of glucocorticoid hormones is considered one of predominant pathological factors inducing osteonecrosis of the femoral head (ONFH) development and progression, in which reduction of blood supply leads to a progressive bone loss and impairment of bone structure in the majority of cases. In a non‑hematopoietic system, erythropoietin (EPO) can stimulate angiogenesis and bone regeneration. However, the specific mechanism underlying the role of EPO in ONFH remains to be elucidated. Therefore, the purpose of this study was to determine the effect of EPO on the prevention of bone loss in ONFH...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28990818/serum-%C3%AE-melanocyte-stimulating-hormone-may-act-as-a-protective-biomarker-for-non-traumatic-osteonecrosis-of-the-femoral-head
#17
Zheng Mao, Gang Liu, Jing-Jie Chen, Dan Liu, Min-Peng Xu, Chang Zhao, Hai-Tao Yang, Yong-Bin Yue
Background The α-melanocyte-stimulating hormone (α-MSH), an endogenous neuropeptide derived from proopiomelanocortin (POMC), has been identified to suppress inflammation and prevent osteoblast damage. Objective The present study was aimed to investigate the role of serum α-MSH in non-traumatic osteonecrosis of the femoral head (ONFH). Methods Seventy-nine patients diagnosed with non-traumatic ONFH and 79 sex- and age-matched healthy controls were enrolled in the study. Serum α-MSH concentrations were examined with a double antibody radioimmunoassay...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28988340/inefficacy-of-autologous-bone-marrow-concentrate-in-stage-three-osteonecrosis-a-randomized-controlled-double-blind-trial
#18
Jean-Philippe Hauzeur, Viviane De Maertelaer, Etienne Baudoux, Michel Malaise, Yves Beguin, Valérie Gangji
PURPOSE: The fracture stage of non-traumatic osteonecrosis (ON stage 3) of the femoral head (ONFH) has an unfavourable prognosis frequently requiring total hip replacement (THR). The percentage could be lowered after core decompression. In earlier non-fracture ON stages, implantation of autologous bone marrow aspirate concentrate (BMAC) improved the effect of core decompression. The purpose was to evaluate the effect of BMAC in addition to core decompression in stage 3 ONFH. METHODS: A double blind RCT was conducted comparing two groups: core decompression plus saline injection or core decompression plus BMAC implantation...
October 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28980933/predictive-role-of-cytokines-il-10-il-12-and-tnf-%C3%AE-gene-polymorphisms-for-the-development-of-osteonecrosis-of-the-femoral-head-in-the-chinese-han-population
#19
L Yuan, W Li, Z B Tian, Y Li, S Sun
The progressive neurodegenerative process in osteonecrosis of the femoral head (ONFH) is accompanied by chronic inflammation, including activation of microglia and astrocytes that express pro-inflammatory cytokines. Up to now, numerous studies of genetic epidemiology have assessed the association of anti- and pro-inflammation cytokines gene polymorphisms and risk of ONFH in different populations, but contradictory results were obtained due to the genetic heterogeneity of in different populations. In the study, 250 ONFH patients and 228 matched healthy controls from Shandong Province were recruited to evaluate the influence of interleukin-10 (IL-10) rs1800872, IL-12 rs3212227 and tumor necrosis factor-(TNF-α) rs1800629 polymorphism in ONFH...
September 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28975995/mir-146a-inhibits-proliferation-and-induces-apoptosis-in-murine-osteoblastic-mc3t3-e1-by-regulating-bcl2
#20
B Zhang, J Yi, C-L Zhang, Q-H Zhang, J-F Xu, H-Q Shen, D-W Ge
OBJECTIVE: The dysregulation of proliferation and apoptosis plays a significant role in the pathogenesis of hormone-induced osteonecrosis of femoral head (ONFH). The research aimed to explore the regulatory role of miR-146a in dexamethasone (DEX)-induced proliferation and apoptosis change in MC3T3-E1 cells from murine osteoblastic. MATERIAL AND METHODS: In this study, MC3T3-E1 was co-cultured with 10-7 DEX for 6 h, then RT-PCR was employed to test the expression level of miR-146a and Bcl2...
October 2017: European Review for Medical and Pharmacological Sciences
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