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https://www.readbyqxmd.com/read/29316952/risk-factor-analysis-for-postoperative-complications-requiring-revision-surgery-after-transtrochanteric-rotational-osteotomy-for-osteonecrosis-of-the-femoral-head
#1
Kazuyuki Karasuyama, Goro Motomura, Satoshi Ikemura, Jun-Ichi Fukushi, Satoshi Hamai, Kazuhiko Sonoda, Yusuke Kubo, Takuaki Yamamoto, Yasuharu Nakashima
BACKGROUND: This study investigated the risk factors for postoperative complications requiring revision surgery within 3 years after transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head (ONFH). METHODS: We reviewed 127 patients (147 hips) who underwent TRO (anterior or posterior rotational osteotomy) for ONFH between January 2002 and December 2014. Two patients were lost to follow-up, and five patients with progression of femoral head collapse requiring a salvage procedure such as total hip arthroplasty within 3 years after TRO were excluded...
January 10, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29312574/association-between-mmp-3-polymorphisms-among-chinese-patients-with-osteonecrosis-of-the-femoral-head
#2
Yuxin Qi, Yong Zhu, Yuju Cao, Huiqiang Wu, Mingqi Sun, Hao Wu, Linlin Pan, Guoqiang Wang, Jianzhong Wang
Many potential causative factors are related to the initiation and progression of osteonecrosis of the femoral head (ONFH). The matrix metalloproteinase/tissue inhibitor of metalloproteinases (MMPs/TIMPs) system was found to play a significant role in the development of ONFH. The aim of this study is to investigate the association between polymorphisms of MMP-3 and ONFH in the Chinese population. We selected 8 single-nucleotide polymorphisms (SNPs) in 2 genes selected from the MMPs/TIMPs system in a case-control study with 585 cases of ONFH and 507 healthy controls...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29296770/osteonecrosis-of-the-femoral-head-in-sickle-cell-disease-prevalence-comorbidities-and-surgical-outcomes-in-california
#3
Oyebimpe Adesina, Ann Brunson, Theresa H M Keegan, Ted Wun
Osteonecrosis of the femoral head (ONFH) is a prevalent complication of sickle cell disease (SCD) that has not been well described in population-based cohort studies. Using California's Office of Statewide Planning and Development discharge databases (1991-2013), we estimated the cumulative incidence of ONFH after accounting for the competing risk of death and used a multivariable Cox proportional hazards regression to identify factors associated with ONFH diagnosis. We also calculated rates of readmissions to the hospital or emergency department within 30 to 90 days of hip replacement surgery...
July 11, 2017: Blood Advances
https://www.readbyqxmd.com/read/29247327/il-21-enhances-the-degradation-of-cartilage-through-the-jak-stat-signaling-pathway-during-osteonecrosis-of-femoral-head-cartilage
#4
Bin Chen, Yi Liu, Lei Cheng
This study aims to investigate the role of interleukin-21 (IL-21) in the mechanism of osteonecrosis of the femoral head. The serum content of IL-21 in patients with osteonecrosis of the femoral head (ONFH) and with femoral neck fracture (FNF) was examined by an enzyme-linked immunosorbent assay (ELISA). The cartilage specimens were stained with safranin-O. The expression of IL-21, tumor necrosis factor-α (TNF-α), cyclooxygenase (COX-2), a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), matrix metalloproteinase-13(MMP-13), and aggrecan in the cartilage was detected, by immunohistochemistry and western blot analysis...
December 15, 2017: Inflammation
https://www.readbyqxmd.com/read/29246013/the-protective-effect-of-pft%C3%AE-on-alcohol-induced-osteonecrosis-of-the-femoral-head
#5
Yi-Xuan Chen, Dao-Yu Zhu, Jun-Hui Yin, Wen-Jing Yin, Yue-Lei Zhang, Hao Ding, Xiao-Wei Yu, Jiong Mei, You-Shui Gao, Chang-Qing Zhang
Epidemiologic studies have shown alcohol plays a pivotal role in the development of osteonecrosis of the femoral head (ONFH). The aim of this study was to explore the underlying mechanism of alcohol-induced ONFH and the protective effect of pifithrin-α (PFTα). In vitro, we found ethanol treatment significantly activated p53, suppressed Wnt/β-catenin signaling and inhibited osteogenic-related proteins. Furthermore, by separating the cytoplasmic and nuclear proteins, we found ethanol inhibited osteogenesis by impairing the accumulation of β-catenin in both the cytoplasm and nucleus in human bone mesenchymal stem cells (hBMSCs), which resulted from activating glycogen synthase kinase-3β (GSK-3β)...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29245246/clinical-analysis-of-23-cases-of-steroid-associated-osteonecrosis-of-the-femoral-head-with-normal-initial-magnetic-resonance-imaging-presentation
#6
Feng-Chao Zhao, Huai-Xia Hu, Xin Zheng, Ding-Wei Cang, Xiaoyun Liu, Jian-Zhi Zhang, Kai-Jin Guo
To explore the clinical characteristics of steroid-associated osteonecrosis of the femoral head (ONFH) presenting initially normal magnetic resonance imaging (MRI) results.This retrospective study examined data from 23 cases that suffered from ONFH but presented a normal image at the first MRI examination after corticosteroid therapy from June 2005 to December 2013. Data on protopathy, age, sex, time of pain onset, MRI examination, and initial diagnosis were collected and analyzed.Average time from steroid therapy to first MRI examination was 45...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29228594/bone-strengthening-pill-bsp-promotes-bone-cell-and-chondrocyte-repair-and-the-clinical-and-experimental-study-of-bsp-in-the-treatment-of-osteonecrosis-of-the-femoral-head
#7
Zheng Li, Lulin Wang, Jin Wei, Liguo Zhu, Xisheng Weng, Jin Jin, Hong Xiao, Jun Zhang, Heming Wang, Guantong Shi, Lingpeng Pei, Fangde Zou, Wanqiang Zhang, Tianzun Tao, Xin Dong
About 1 in 3 people suffer from bone and joint disease, which is a disease of bone and cartilage cells. Osteonecrosis of the femoral head (ONFH) is a typical example of bone and joint disease involving bone cell necrosis. Osteonecrosis of the femoral head leads to the occurrence of premature osteoarthritis of the hip and collapse of the cartilage cells, and there is currently no effective drug treatment available. In order to study the effects of "bone-strengthening pill" (BSP) on the repair of bone and cartilage cells, we investigated the potential effects of the herbal mixture BSP in an animal model of avascular necrosis of the femoral head and in patients...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205600/circulating-microrna-signature-of-steroid-induced-osteonecrosis-of-the-femoral-head
#8
Zheng Li, Chao Jiang, Xingye Li, William K K Wu, Xi Chen, Shibai Zhu, Chanhua Ye, Matthew T V Chan, Wenwei Qian
OBJECTIVES: Steroid-induced osteonecrosis of the femoral head (ONFH) is a common orthopaedic disease of which early detection remains clinically challenging. Accumulating evidences indicated that circulating microRNAs (miRNAs) plays vital roles in the development of several bone diseases. However, the association between circulating miRNAs and steroid-induced ONFH remains elusive. MATERIALS AND METHODS: miRNA microarray was performed to identify the differentially abundant miRNAs in the serums of systemic lupus erythematosus (SLE) patients with steroid-induced ONFH as compared with SLE control and healthy control group...
December 4, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29201897/combined-treatment-with-an-anticoagulant-and-a-vasodilator-prevents-steroid-associated-osteonecrosis-of-rabbit-femoral-heads-by-improving-hypercoagulability
#9
Fang Cao, Ge Liu, Wei Wang, Benjie Wang, Xiaowei Wei, Faqiang Lu, Fan Yang, Kai Kang, Yongxuan Wang, Jiahui Yang, Kairong Qin, Dewei Zhao
Steroid-associated osteonecrosis of the femoral head remains a challenging problem in orthopedics worldwide. One pathomechanism is ischemia of the femoral head, as a result of thrombus formation and vasoconstriction. The present study investigates the effects of combination prevention with enoxaparin and EGb 761 on steroid-associated ONFH in rabbits. Rabbits were randomly divided into 5 groups (control group, model group, enoxaparin group, ginkgo group, and combination group). With the exception of the control group, the groups of rabbits were modeled with lipopolysaccharide and methylprednisolone acetate...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29167942/prognostic-analysis-of-different-morphology-of-the-necrotic-viable-interface-in-osteonecrosis-of-the-femoral-head
#10
Wei Wu, Wei He, Qiu-Shi Wei, Zhen-Qiu Chen, Da-Wei Gao, Peng Chen, Qing-Wen Zhang, Bin Fang, Lei-Lei Chen, Bao-Ling Li
PURPOSE: The purpose of this study was to investigate the collapse progression in different morphologies of the necrotic-viable interface in osteonecrosis of the femoral head (ONFH). METHODS: A total of 168 patients (202 hips) with Association Research Circulation Osseous (ARCO) stage II ONFH were included. Ending with the collapse of the femoral head, all patients received conservative treatment but without surgical intervention and were followed for three to 91 months...
November 22, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29162080/modifications-to-advanced-core-decompression-for-treatment-of-avascular-necrosis-of-the-femoral-head
#11
Stefan Landgraeber, Sebastian Warwas, Tim Claßen, Marcus Jäger
BACKGROUND: "Advanced Core Decompression" (ACD) is a new technique for treatment of osteonecrosis of the femoral head (ONFH) that includes removal of the necrotic tissue using a percutaneous expandable reamer followed by refilling of the drill hole and the defect with an injectable, hard-setting, composite calcium sulphate (CaSO4)-calcium phosphate (CaPO4) bone graft substitute. As autologous bone has been shown to be superior to all other types of bone grafts, the aim of the study is to present and evaluate a modified technique of ACD with impaction of autologous bone derived from the femoral neck into the necrotic defect...
November 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29154968/non-traumatic-osteonecrosis-of-the-femoral-head-is-associated-with-low-bone-mass
#12
Valérie Gangji, Muhammad S Soyfoo, Audrey Heuschling, Violaine Afzali, Rodrigo Moreno-Reyes, Joanne Rasschaert, Céline Gillet, Jean-Francois Fils, Jean-Philippe Hauzeur
OBJECTIVE: Osteoporosis (OP) and osteonecrosis of the femoral head (ONFH) share common clinical and pathophysiological features we sought to determine whether ONFH was associated with an increased prevalence of OP and whether the increased prevalence of OP was related to the stage of ONFH at diagnosis. METHODS: We included 243 patients with ONFH and 399 age and sex-matched healthy controls. Data was gathered including demography, risk factors, ARCO staging of ONFH and bone mineral density (BMD)...
November 14, 2017: Bone
https://www.readbyqxmd.com/read/29151233/clinical-results-of-hemiarthroplasty-using-new-bipolar-cups-for-stage-3-or-lower-osteonecrosis-of-the-femoral-head-a-retrospective-study
#13
T Abe, N Kaku, T Tabata, H Tagomori, H Tsumura
PURPOSE: The aim of this study was to evaluate clinical and radiographic findings of stage 3 or lower osteonecrosis of the femoral head (ONFH) with intact acetabular cartilage in patients treated with bipolar hemiarthroplasty (BHA). METHODS: A total of 79 hips that underwent BHA for ONFH were included in this study. The average observation period was 7.6 years. Clinical results were evaluated using the Harris hip score. We performed radiographic analysis to assess the migration of the outer cup, the permanent image around the outer cup, and loosening of the stem...
November 18, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29137306/mmp9-polymorphism-is-associated-with-susceptibility-to-non-traumatic-osteonecrosis-of-femoral-head-in-a-chinese-han-population
#14
Yuan Liu, Yanfei Jia, Yuju Cao, Yan Zhao, Jieli Du, Feimeng An, Yuxin Qi, Xue Feng, Tianbo Jin, Jianping Shi, Jianzhong Wang
Non-traumatic osteonecrosis of femoral head (ONFH) is an orthopedic refractory disease with escalating morbidity in Chinese Han population. In our case-control study, we examined eight previously identified MMP9 single-nucleotide polymorphisms (SNPs) in 585 non-traumatic ONFH patients and 507 healthy individuals from northern China to determine whether these SNPs associated with the risk of developing non-traumatic ONFH. Genetic model and haplotype analyses were used to evaluate the association between SNPs and non-traumatic ONFH...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136757/muscone-exerts-protective-roles-on-alcohol-induced-osteonecrosis-of-the-femoral-head
#15
Yan-Jie Guo, Shi-Hua Luo, Ming-Jie Tang, Zu-Bin Zhou, Jun-Hui Yin, You-Shui Gao, Xiao-Qian Dang
Long-term alcohol abuse causes musculoskeletal disorders, among of which, alcohol-induced osteonecrosis of the femoral head (ONFH) is of concern due to its significant and severe complications. A variety of methods have been attempted to prevent alcohol-induced ONFH, and monomers extracted from Chinese herbs might benefit the disease profoundly. In the current study, muscone, the main ingredient of musk, was used to prevent alcohol-induced ONFH. In vitro, ethanol was used to affect the potential of osteogenesis and proliferation of human bone mesenchymal stem cells (hBMSCs), and beneficial role of muscone was investigated on hBMSCs...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136173/high-levels-of-gsk-3%C3%AE-signaling-reduce-osteogenic-differentiation-of-stem-cells-in-osteonecrosis-of-femoral-head
#16
Lu Huang, Ying Wang, Yangzi Jiang, Yan Wu, Changchang Hu, Hongwei Ouyang
Osteonecrosis of the femoral head (ONFH) is a common but intractable disease. In this study, we investigated the mechanisms regulating alterations in mesenchymal stem cell (MSC) differentiation in ONFH. Five patients who were diagnosed with ONFH were enrolled in this study. BMSCs were isolated from the osteonecrotic zone in the femoral head (FH-pMSCs) and from the normal zone in the pelvis (hMSCs) of the same patient. Morphology, cell proliferation, and expression of mediators of the Wnt signaling pathway were evaluated...
November 10, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29131454/emerging-roles-of-micrornas-in-osteonecrosis-of-the-femoral-head
#17
REVIEW
Zheng Li, Bo Yang, Xisheng Weng, Gary Tse, Matthew T V Chan, William Ka Kei Wu
Osteonecrosis of the femoral head (ONFH) is one of the most common orthopaedic diseases. The exact pathogenic mechanism of ONFH is still unknown. MicroRNAs (miRNAs) are a class of non-coding RNAs that negatively modulate gene expression at post-transcriptional level. An increasing number of studies have shown that miRNAs play crucial roles in different physiological processes, including development, cell proliferation, differentiation and metabolism. Recently, multiple studies demonstrated that miRNAs are involved in the pathogenesis of ONFH...
November 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29120670/correlation-between-steroid-induced-osteonecrosis-of-the-femoral-head-and-hepatic-cyp3a-activity-a-systematic-review-and-meta-analysis
#18
Fa-Qi Guo, Min Deng
BACKGROUND: Steroid-induced osteonecrosis of the femoral head (ONFH) in young adults is a challenging disorder that can impairs the quality of life of a patient. The disease also leads to frequent occurrences of collapse of the femoral head and resultant dysfunction of the hip joint. In recent years, some scholars have studied steroid-induced lipid metabolism disorder and achieved the effect of steroid-induced ONFH treatment. This study aims to review the investigations on the hepatic CYP3A (cytochrome P4503A enzyme) genetic polymorphisms in steroid-induced ONFH patients...
November 9, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29089773/a-12-year-follow-up-study-of-combined-treatment-of-post-severe-acute-respiratory-syndrome-patients-with-femoral-head-necrosis
#19
Tiansheng Liu, Jinchao Ma, Bin Su, Hao Wang, Qi Wang, Xinlong Ma
OBJECTIVE: To investigate the long-term efficacy of a combination treatment of alendronate, extracorporeal shock and hyperbaric oxygen for osteonecrosis of the femoral head (ONFH) of post-severe acute respiratory syndrome (SARS) patients. PATIENTS AND METHODS: The retrospective study was performed including a total of 37 post-SARS ONFH patients (66 hip joints) in the Department of Orthopedics of the General Hospital of Tianjin Medical University between November 2003 and November 2015, consisting of 6 males (11 hip joints) and 31 females (55 hip joints), with age between 19 and 47 years (average 29...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29069795/variants-of-gsk3%C3%AE-and-sfrp4-genes-in-wnt-signaling-were-not-associated-with-osteonecrosis-of-the-femoral-head
#20
Yang Song, Zhenwu Du, Qiwei Yang, Ming Ren, Qingyu Wang, Gaoyang Chen, Haiyue Zhao, Zhaoyan Li, Guizhen Zhang
Genome-wide association studies have identified that the gene variants in Wnt signaling associate with bone mineral density and fracture risk but the effects of the variants on the development of osteonecrosis of the femoral head (ONFH) have been unclear. Here, we analyzed the polymorphisms of 4 variants in GSK3β and SFRP4 genes of Wnt signaling and their association with the development of ONFH through Mass ARRAY(®) platform in 200 ONFH patients and 177controls in Chinese population. Our results showed that the genotypes and allele frequencies of all variants detected in SFRP4 and GSK3β genes were not significantly different between patients and controls (p > 0...
September 22, 2017: Oncotarget
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