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JOURNAL ARTICLE
Kangpeng Li, Rui Ma, Rugang Zhao, Qiang Zhang
BACKGROUND: In the post-epidemic era, Acquired Immune Deficiency Syndrome (AIDS) remains one of the most prevalent and detrimental infectious diseases worldwide. The incidence of osteonecrosis of the femoral head (ONFH) in AIDS patients is 100 times higher than that in healthy individuals. Although Total Hip Arthroplasty (THA) is ultimately necessary for most patients, there is still a dearth of evidence regarding its safety and efficacy in Chinese AIDS patients. METHODS: The clinical data of 49 patients who met the inclusion and exclusion criteria were retrospectively analyzed...
April 17, 2024: Current HIV Research
#2
JOURNAL ARTICLE
Na Yuan, Weiying Zhang, Weizhou Yang, Wenchen Ji, Jia Li
Inflammatory reactions are involved in the development of steroid-induced osteonecrosis of the femoral head(ONFH). Studies have explored the therapeutic efficacy of inhibiting inflammatory reactions in steroid-induced ONFH and revealed that inhibiting inflammation may be a new strategy for preventing the development of steroid-induced ONFH. Exosomes derived from M2 macrophages(M2-Exos) display anti-inflammatory properties. This study aimed to examine the preventive effect of M2-Exos on early-stage steroid-induced ONFH and explore the underlying mechanisms involved...
April 16, 2024: Journal of Orthopaedic Surgery and Research
#3
JOURNAL ARTICLE
Xiaoxiao Zhou, Shengyang Guo, Wenjun Pan, Linyuan Zhang, Houlin Ji, Yang Yang
OBJECTIVE: Femoral neck fractures (FNFs) are among the most common fractures in elderly individuals. Surgery is the main treatment for FNFs, and osteonecrosis of the femoral head (ONFH) is one of the unacceptable complications. This study aimed to assess both the clinical and radiological outcomes in patients with FNFs treated with three parallel cannulated screws and to identify relationship between screws position and ONFH. PATIENTS AND METHODS: A total of 100 patients who were treated with closed reduction and fixed with 3 parallel cannulated screws met the inclusion criteria between January 2014 and December 2020 at authors' institution...
April 13, 2024: BMC Musculoskeletal Disorders
#4
JOURNAL ARTICLE
Qing-Yuan Zheng, Ye Tao, Lei Geng, Peng Ren, Ming Ni, Guo-Qiang Zhang
OBJECTIVE: Osteonecrosis of the femoral head (ONFH) is a severe disease that primarily affects the middle-aged population, imposing a significant economic and social burden. Recent research has linked the progression of non-traumatic osteonecrosis of the femoral head (NONFH) to the composition of the gut microbiota. Steroids and alcohol are considered major contributing factors. However, the relationship between NONFH caused by two etiologies and the microbiota remains unclear. In this study, we examined the gut microbiota and fecal metabolic phenotypes of two groups of patients, and analyzed potential differences in the pathogenic mechanisms from both the microbial and metabolic perspectives...
April 12, 2024: Journal of Orthopaedic Surgery and Research
#5
JOURNAL ARTICLE
Jiaqi Shi, Li Chen, Xu Wang, Xin Ma
Steroid-induced osteonecrosis of the femoral head (ONFH) is a serious complication caused by long-term or excessive use of glucocorticoids. The present study aimed to ascertain the effects of tripartite motif-containing protein 21 (TRIM21) on the process of steroid-induced ONFH and its hidden action mechanism. TRIM21 expression in dexamethasone (Dex)-treated mouse MC3T3-E1 preosteoblast cells was examined using reverse transcription-quantitative PCR and western blotting. The Cell Counting Kit-8 (CCK-8) method and lactate dehydrogenase release assay were used to respectively measure cell viability and injury...
May 2024: Experimental and Therapeutic Medicine
#6
JOURNAL ARTICLE
Peng Shang, Ying Liu, Jie Ren, Qingqing Liu, Haobo Song, Junqing Jia, Qiang Liu
This study is to probe into the meaning of serum miR-532-5p in nontraumatic osteonecrosis of the femoral head (ONFH), and a molecular mechanism of miR-532-5p in the development of nontraumatic ONFH. This study enrolled 96 patients diagnosed with nontraumatic ONFH and 96 patients with femoral neck fracture. The levels of miR-532-5p, ABL1, MMP-3, MMP-13, and cleaved-caspase3 were determined. Radiographic progression was assessed by ARCO staging system. Visual analog scale (VAS) and Harris hip score (HHS) were employed for evaluation of the symptomatic severity of nontraumatic ONFH...
2024: Open Medicine (Warsaw, Poland)
#7
JOURNAL ARTICLE
Yusuke Ayabe, Goro Motomura, Satoshi Ikemura, Ryosuke Yamaguchi, Takeshi Utsunomiya, Noriko Yamamoto, Hidenao Tanaka, Satoshi Hamai, Shinya Kawahara, Yasuharu Nakashima
BACKGROUND: This study assessed the hip survival rate and patient-reported outcome measures (PROMs) of transtrochanteric curved varus osteotomy (CVO) for osteonecrosis of the femoral head (ONFH) compared with those of conservative management. METHODS: The CVO group comprised 32 consecutive patients (39 hips) who underwent CVO for ONFH between 2000 and 2011. The conservative group consisted of 36 consecutive patients (37 hips) who were managed conservatively for at least 1 year after collapse and who had ONFH classified by the Japanese Investigation Committee of Health and Welfare as type B or C1, for which CVO is indicated...
April 2, 2024: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
#8
JOURNAL ARTICLE
Junichi Nakamura, Wakaba Fukushima, Wataru Ando, Shigeo Hagiwara, Yuya Kawarai, Yuki Shiko, Yohei Kawasaki, Takashi Sakai, Kazuya Ito, Yoshiya Arishima, Etsuo Chosa, Yusuke Fujimoto, Kazuo Fujiwara, Yukiharu Hasegawa, Shinya Hayashi, Takashi Imagama, Yutaka Inaba, Yasuyuki Ishibashi, Yasuhiro Ishidou, Hideya Ito, Hiroshi Ito, Juji Ito, Tetsuya Jinno, Tamon Kabata, Nobuhiro Kaku, Ayumi Kaneuji, Shunji Kishida, Seneki Kobayashi, Setsuro Komiya, Toshikazu Kubo, Tokifumi Majima, Naohiko Mashima, Masaaki Mawatari, Hidenobu Miki, Kazumasa Miyatake, Goro Motomura, Satoshi Nagoya, Hiroaki Nakamura, Yoshihide Nakamura, Ryosuke Nakanishi, Yasuharu Nakashima, Satoshi Nakasone, Takashi Nishii, Takayuki Nishiyama, Yoichi Ohta, Kenji Ohzono, Makoto Osaki, Kan Sasaki, Taisuke Seki, Takaaki Shishido, Takeshi Shoji, Akihiro Sudo, Michiaki Takagi, Daisuke Takahashi, Masaki Takao, Sakae Tanaka, Takeyuki Tanaka, Tomonori Tetsunaga, Keiichiro Ueshima, Kengo Yamamoto, Takuaki Yamamoto, Yuji Yamamoto, Takuma Yamasaki, Yuji Yasunaga, Nobuhiko Sugano
OBJECTIVES: This study documents the time elapsed from the diagnosis of osteonecrosis of the femoral head (ONFH) to surgery, exploring the factors that influence ONFH severity. DESIGN: Retrospective observational study of a nationwide database. SETTING: The Kaplan-Meier method with log-rank tests was applied to examine the period from definitive diagnosis of ONFH to surgery using any surgery as the end point. For bilateral cases, the date of the first surgery was the endpoint...
March 29, 2024: BMJ Open
#9
Joo-Hyoun Song, Young Wook Lim, Se-Won Lee, Hyun Woo Park, Howon Jeong, Seungbae Oh
INTRODUCTION: A fracture of the ceramic head in bipolar hemiarthroplasty using an inner polyliner has not been reported yet, and there seems to be no report of simultaneous breakage of the fourth-generation BIOLOX Delta ceramic head and liner in total hip arthroplasty. METHOD: A 44-year-old male patient underwent bipolar hemiarthroplasty using a third-generation BIOLOX Forte ceramic head 3 years and 9 months earlier for osteonecrosis of femoral head (ONFH) and visited our hospital due to a ceramic head fracture...
April 2024: Indian Journal of Orthopaedics
#10
REVIEW
Wenkai Shao, Ping Wang, Xiao Lv, Bo Wang, Song Gong, Yong Feng
Osteonecrosis of the femoral head (ONFH) is a disabling disease characterized by the disruption of the blood supply to the femoral head, leading to the apoptosis and necrosis of bone cells and subsequent joint collapse. Total hip arthroplasty is not optimal since most patients are young. Multiple risk factors contribute to osteonecrosis, including glucocorticoid (GC) usage, excessive alcohol intake, hypercholesterolemia, and smoking. Continuous stimulation by many variables causes a chronic inflammatory milieu, with clinical repercussions including endothelial dysfunction, leading to thrombosis, coagulopathy, and poor angiogenesis...
March 15, 2024: Biomedicines
#11
JOURNAL ARTICLE
Chuankai Shi, Xin Li, Yu Sun, Zhenwu Du, Guizhen Zhang, Zhenjia Che, Qingyu Li, Shiliang Song, Jing Guo, Haoyan Sun, Yang Song
The genes of Wnt/β-catenin pathway may have potential roles in fat accumulation of Non-traumatic osteonecrosis of the femoral head (ONFH), but the effects of their variants in the pathway on ONFH development have been remained unclear. To explore the potential roles of the variants in the development of ONFH, we completed the investigation of the paired interactions as well as their related biological functions of 17 variants of GSK3β, LRP5, and FRP4 genes etc. in the pathway. The genotyping of the 17 variants were finished by MASS ARRAY PLATFORM in a 560 ONFH case-control system...
March 27, 2024: Scientific Reports
#12
JOURNAL ARTICLE
Hongbin Luo, Jie Wei, Songye Wu, Qunya Zheng, Xinhua Lin, Peng Chen
BACKGROUND: Steroid-induced osteonecrosis of the femoral head (SONFH) is a prevalent and incapacitating condition that affects the hip joint. Unfortunately, early diagnostic and treatment measures are limited. METHODS: Our study employed Tandem Mass Tag (TMT) labeling mass spectrometry (MS)-based quantitative proteome to compare the proteins of femoral head tissues in patients with SONFH with those of patients who sustained femoral neck fracture (FNF). We investigated the level and effects of glucose transporter member 1 (GLUT1) in SONFH patients and MC3T3-E1 cells and examined the function and molecular mechanism of GLUT1 in the context of SONFH using in vivo and in vitro approaches...
March 20, 2024: Bone
#13
JOURNAL ARTICLE
Shengbao Chen, Kai Fu, Qianying Cai, Yong Feng, Haiyan He, Yun Gao, Zhenzhong Zhu, Dongxu Jin, Jiagen Sheng, Changqing Zhang
Identification and differentiation of appropriate indications on hip preserving with bone grafting therapy remains a crucial challenge in the treatment of osteonecrosis of the femoral head (ONFH). A prospective cohort study on bone grafting therapy for ONFH aimed to evaluate hip survival rates, and to establish a risk scoring derived from potential risk factors (multivariable model) for hip preservation. Eight variables were identified to be strongly correlated with a decreased rate of hip survival post-therapy, and a comprehensive risk scoring was developed for predicting hip-preservation outcomes...
April 19, 2024: IScience
#14
JOURNAL ARTICLE
Congcong Luo, Yiping Dong, Qiang Yuan, Ning Zhang, Ying Zhang
OBJECTIVE: To evaluate the correlation between pelvic incidence (PI) angle, hip deflection angle (HDA), combined deflection angle (CDA) and osteonecrosis of the femoral head (ONFH) after femoral neck fracture, in order to explore early predictive indicators for ONFH occurrence after femoral neck fracture. METHODS: A study was conducted on patients with femoral neck fractures who underwent cannulated screw internal fixation between December 2018 and December 2020...
March 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
#15
JOURNAL ARTICLE
Weihua Fang, Peng Peng, Kun Lin, Fangjun Xiao, Wei He, Mincong He, Qiushi Wei
Osteonecrosis of the femoral head (ONFH) is a elaborate hip disease characterized by collapse of femoral head and osteoarthritis. RNA N6-methyladenosine (m6A) plays a crucial role in a lot of biological processes within eukaryotic cells. However, the role of m6A in the regulation of ONFH remains unclear. In this study, we identified the m6A regulators in ONFH and performed subtype classification. We identified 7 significantly differentially expressed m6A regulators through the analysis of differences between ONFH and normal samples in the Gene Expression Omnibus (GEO) database...
March 15, 2024: Journal of Orthopaedic Surgery and Research
#16
JOURNAL ARTICLE
Chen Qiu, Zhaowen Li, Puji Peng
OBJECTIVE: To investigate the protective effect human umbilical cord mesenchymal stem cells (hUC-MSCs) have on Dexamethasone (Dex)-induced apoptosis in osteogenesis via the Nrf2-ARE signaling pathway. METHODS: Glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH) was developed in rats through the administration of lipopolysaccharide and methylprednisolone. The incidence of femoral head necrosis, cavity notch, apoptosis of osteoblasts, and bone density were observed by HE staining, TUNEL staining, and Micro-CT...
December 2024: Regenerative Therapy
#17
JOURNAL ARTICLE
Tianyu Wang, Dongwei Wu, Chengsi Li, Xinqun Cheng, Zhenbang Yang, Yingze Zhang, Yanbin Zhu
BACKGROUND: No large cohort study has evaluated the surgical outcomes of THA between different stages of ONFH patients. This study aimed to compare the surgical outcomes of ONFH patients who underwent THA in ARCO stage III versus IV, in terms of operative parameters, one-year hip function assessments and postoperative at least five-year complications, to inform optimized management of ONFH. METHOD: From our prospectively collected database, 876 patients undergoing THA between October 2014 and April 2017 were analyzed and divided into ARCO stage III group (n = 383) and ARCO stage IV group(n = 493)...
March 6, 2024: Journal of Orthopaedic Surgery and Research
#18
JOURNAL ARTICLE
Masamichi Onaga, Satoshi Nakasone, Masato Ishihara, Takahiro Igei, Fumiyuki Washizaki, Sakura Kuniyoshi, Kotaro Nishida
BACKGROUND: In total hip arthroplasty (THA) after failed transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head (ONFH), deformity of the proximal femur has been reported to affect stem placement. The aims of this study were to evaluate the morphological changes in the proximal femur, muscle atrophy, and soft tissue thickening in THA after TRO and the clinical outcomes. METHODS: The TRO group included 17 patients (18 hips) who underwent THA after failed TRO...
March 4, 2024: BMC Musculoskeletal Disorders
#19
REVIEW
Yutaka Kuroda, Toshiyuki Kawai, Yaichiro Okuzu, Yugo Morita, Shuichi Matsuda
INTRODUCTION: Osteonecrosis of the femoral head (ONFH) is arefractory disease requiring joint replacement in young patients. Regenerativetherapies have been developed. AREAS COVERED: This study surveyed clinical trials onregenerative medicine for ONFH. We extractedclinical trials on non-traumatic ONFH from the websites of five publiclyavailable major registries (EuropeanUnion Clinical Trials Register ([EU-CTR],ClinicalTrials.gov, Chinese ClinicalTrial Registry [ChiCTR], University Hospital Medical InformationNetwork - Clinical Trial Registry [UMIN-CTR] and Australian New Zealand Clinical Trials Registry [ANZCTR])...
March 2, 2024: Expert Opinion on Investigational Drugs
#20
JOURNAL ARTICLE
Jiping Zhang, Sijia Guo, Degang Yu, Cheng-Kung Cheng
PURPOSE: Osteonecrosis of the femoral head (ONFH) is a severe bone disease that can progressively lead to hip dysfunction. Accurately segmenting the necrotic lesion helps in diagnosing and treating ONFH. This paper aims at enhancing deep learning models for necrosis segmentation. METHODS: Necrotic lesions of ONFH are confined to the femoral head. Considering this domain knowledge, we introduce a preprocessing procedure, termed the "subtracting-adding" strategy, which explicitly incorporates this domain knowledge into the downstream deep neural network input...
March 2, 2024: International Journal of Computer Assisted Radiology and Surgery
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