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https://www.readbyqxmd.com/read/28901487/association-of-srebp2-gene-polymorphisms-with-the-risk-of-osteonecrosis-of-the-femoral-head-relates-to-gene-expression-and-lipid-metabolism-disorders
#1
Yang Song, Zhenwu Du, Bingpeng Chen, Ming Ren, Qiwei Yang, Yujie Sui, Qingyu Wang, Ao Wang, Haiyue Zhao, Yanguo Qin, Guizhen Zhang
Although lipid metabolism disorders have been recognized as a primary factor of osteonecrosis of the femoral head (ONFH), the molecular pathogenesis remains unclear. Sterol regulatory element‑binding protein 2 (SREBP2) specifically regulates cholesterol and fatty acid metabolism to maintain lipid homeostasis. To explore the roles of the SREBP2 gene in the development of ONFH, the authors analyzed the gene polymorphism and gene expression of three tag single nucleotide polymorphisms of the SREBP2 gene, the serum lipids levels, and their associations with ONFH development in 182 ONFH patients and 179 healthy controls...
September 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28805950/management-of-osteonecrosis-of-the-femoral-head-with-pedicled-iliac-bone-flap-transfer-a-multicenter-study-of-2190-patients
#2
Dewei Zhao, Hui Xie, Yongqing Xu, Yisheng Wang, Aixi Yu, Youwen Liu, Aimin Wang, Wei He, Xiuli Wang, Zirong Li, Wei Sun, Simiao Tian, Benjie Wang, Baoyi Liu
BACKGROUND: Osteonecrosis of the femoral head (ONFH) often affects young active adults and leads to destruction of the hip joint and disabling arthritis. Several procedures have been developed to arrest the progress of osteonecrosis and postpone the procedure of total hip replacement especially in young patients. The aim of this multicenter study was to analyze the results of the use of the vascularized iliac bone flap transfer for management of ONFH. METHODS: From January 1985 to December 2012, a total of 2190 patients (2690 hips) with the mean age of 43...
August 14, 2017: Microsurgery
https://www.readbyqxmd.com/read/28782831/customized-degradable-functionally-graded-scaffold-for-potential-treatment-of-early-stage-osteonecrosis-of-the-femoral-head
#3
Toshiyuki Kawai, Yaser Shanjani, Saba Fazeli, Anthony W Behn, Yaichiro Okuzu, Stuart B Goodman, Yunzhi P Yang
Osteonecrosis of the femoral head (ONFH) is a debilitating disease that results in progressive collapse of the femoral head and subsequent degenerative arthritis. Few treatments provide both sufficient mechanical support and biological cues for regeneration of bone and vascularity when the femoral head is still round and therefore salvageable. We designed and 3D printed a functionally graded scaffold (FGS) made of polycaprolactone (PCL) and β-tricalcium phosphate (β-TCP) with spatially controlled porosity, degradation, and mechanical strength properties to reconstruct necrotic bone tissue in the femoral head...
August 7, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28782700/effects-of-intertrochanteric-osteotomy-plane-and-pre-operative-femoral-anteversion-on-the-post-operative-morphology-of-the-proximal-femur-in-transtrochanteric-anterior-rotational-osteotomy-3d-ct-based-simulation-study
#4
Kazuhiko Sonoda, Goro Motomura, Satoshi Ikemura, Yusuke Kubo, Takuaki Yamamoto, Yasuharu Nakashima
BACKGROUND: Transtrochanteric anterior rotational osteotomy (ARO) is joint-preserving surgery for patients with osteonecrosis of the femoral head (ONFH).During ARO, femoral neck-shaft varus angulation by changing intertrochanteric osteotomy plane is often designed to obtain a sufficient post-operative intact ratio. However, the effect of intertrochanteric osteotomy plane on post-operative femoral anteversion has not been well examined.Therefore we performed a simulation study of ARO to determinehow intertrochanteric osteotomy plane and pre-operative femoral anteversionaffect both femoral neck-shaft varus angle and post-operative femoral anteversion...
August 3, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28777523/transient-osteoporosis-of-the-hip-treated-with-hyperbaric-oxygen-therapy-a-case-series
#5
Kazuyoshi Yagishita, Tetsuya Jinno, Daisuke Koga, Tsuyoshi Kato, Mitsuhiro Enomoto, Tsuyoshi Kato, Takeshi Muneta, Atsushi Okawa
INTRODUCTION: Transient osteoporosis of the hip (TOH) is a self-limiting disorder characterized by bone marrow edema at the femoral head and neck. Patients report pain as moderate or severe at onset; pain gradually subsides at about six months (range four to 12 months). Differential diagnosis of the early stages of osteonecrosis of the femoral head (ONFH) is sometimes difficult. Because hyperbaric oxygen (HBO₂) therapy is effective for reduction of edema in soft tissue injury and early stages of ONFH, we hypothesized that HBO₂ could be effective in TOH for accelerated recovery...
November 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28770971/apolipoprotein-a1-and-neuronal-nitric-oxide-synthase-gene-polymorphisms-and-hormone-related-osteonecrosis-of-the-femoral-head
#6
L Chen, P Wei, K Jiang, X-X Xia
OBJECTIVE: This study was designed to investigate the influence of several polymorphisms in neuronal NOS genes and apolipoprotein AI on the hormone-related osteonecrosis of the femoral head (ONFH) risk. PATIENTS AND METHODS: Peripheral blood mononuclear cell (PBMCs) samples extracted from hormone-related ONFH patients and controls were used to amplify fragments of the apolipoprotein A1 and neuronal NOS exon 7 and intron 4 using specific PCR primers. The products were analyzed by DNA sequencing and mapped to find the genotype distributions...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28732374/the-protective-effect-of-pft%C3%AE-on-alcohol-induced-osteonecrosis-of-the-femoral-head
#7
Yi-Xuan Chen, Dao-Yu Zhu, Jun-Hui Yin, Wen-Jing Yin, Yue-Lei Zhang, Hao Ding, Xiao-Wei Yu, Jiong Mei, You-Shui Gao, Chang-Qing Zhang
Epidemiologic studies have shown alcohol plays a pivotal role in the development of osteonecrosis of the femoral head (ONFH). The aim of this study was to explore the underlying mechanism of alcohol-induced ONFH and the protective effect of pifithrin-α (PFTα). In vitro, we found ethanol treatment significantly activated p53, suppressed Wnt/β-catenin signaling and inhibited osteogenic-related proteins. Furthermore, by separating the cytoplasmic and nuclear proteins, we found ethanol inhibited osteogenesis by impairing the accumulation of β-catenin in both the cytoplasm and nucleus in human bone mesenchymal stem cells (hBMSCs), which resulted from activating glycogen synthase kinase-3β (GSK-3β)...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28716026/short-stem-total-hip-arthroplasty-for-osteonecrosis-of-the-femoral-head-in-patients-60%C3%A2-years-or-younger-a-3-to-10-year-follow-up-study
#8
Antonio Capone, Fabrizio Bienati, Stefania Torchia, Daniele Podda, Giuseppe Marongiu
BACKGROUND: In young patients with osteonecrosis of the femoral head (ONFH), short-stem total hip arthroplasty (THA) could allow a potential advantage in preserving metaphyseal bone-stock, when revision surgery might become necessary. However, only a few studies have evaluated the outcome of short-stem THAs in ONFH. We reviewed the prospectively collected data of a cementless partial neck-retaining short-stem with ceramic-on-ceramic bearings in ONFH patients. METHODS: Thirty patients (37 hips) younger than 60 years (mean age at surgery, 51...
July 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28698612/eif2%C3%AE-signaling-regulates-ischemic-osteonecrosis-through-endoplasmic-reticulum-stress
#9
Daquan Liu, Yunlong Zhang, Xinle Li, Jie Li, Shuang Yang, Xiaoxue Xing, Guanwei Fan, Hiroki Yokota, Ping Zhang
Osteonecrosis of the femoral head (ONFH) primarily results from ischemia/hypoxia to the femoral head, and one of the cellular manifestations is the endoplasmic reticulum (ER) stress. To understand possible linkage of ischemic osteonecrosis to the ER stress, a surgery-induced animal model was employed and salubrinal was administered to evaluate the role of ER stress. Salubrinal is a synthetic chemical that inhibits de-phosphorylation of eIF2α, and it can suppress cell death from the ER stress at a proper dose...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28689862/histological-fibrosis-may-predict-the-failure-of-core-decompression-in-the-treatment-of-osteonecrosis-of-the-femoral-head
#10
Francesco Sadile, Alessio Bernasconi, Flavio Carbone, François Lintz, Gelsomina Mansueto
PURPOSE: Osteonecrosis of femoral head (ONFH) is histopathologically characterized by necrotic areas associated with reactive fibrosis, trabecular bone remodeling and thickening zones. Our double goal was to evaluate if: 1) main ONFH risk factors were related to specific histological specimen patterns 2) different histological patterns were related to the final outcome after a core decompression (CD) procedure. METHODS: This observational longitudinal cohort study respected the STROBE statement...
July 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28685377/alcohol-intake-and-the-risk-of-osteonecrosis-of-the-femoral-head-in-japanese-populations-a-dose-response-meta-analysis-of-case-control-studies
#11
Byung-Ho Yoon, Tae-Young Kim, In-Soo Shin, Hee Young Lee, Yun Jong Lee, Kyung-Hoi Koo
Studies examining the association between alcohol intake and the risk of osteonecrosis of the femoral head (ONFH) have inconsistent results. The purpose of this study was to examine and summarize the evidence regarding the association between alcohol intake and ONFH based on results from case-control studies. This analysis included five case-control studies reporting data from 1251 individuals. Alcohol intake habits (never, former, or current), average drinking consumption (g/week), and cumulative drinking consumption (drink-years) were extracted...
July 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28683795/hip-preserving-surgery-with-concentrated-autologous-bone-marrow-aspirate-transplantation-for-the-treatment-of-asymptomatic-osteonecrosis-of-the-femoral-head-retrospective-review-of-clinical-and-radiological-outcomes-at-6%C3%A2-years-postoperatively
#12
Yohei Tomaru, Tomokazu Yoshioka, Hisashi Sugaya, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Masashi Yamazaki, Hajime Mishima
BACKGROUND: We had previously established concentrated autologous bone marrow aspirate transplantation (CABMAT), a one-step, low-invasive, joint-preserving surgical technique for treating osteonecrosis of the femoral head (ONFH). The present study aimed to evaluate the effects of CABMAT as a hip preserving surgical approach, preventing femoral head collapse in asymptomatic ONFH. METHODS: In total, 222 patients (341 hips) with ONFH were treated with CABMAT between April 2003 and March 2013...
July 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28682898/heterotopic-ossification-related-to-the-use-of-recombinant-human-bmp-2-in-osteonecrosis-of-femoral-head
#13
Lijun Shi, Wei Sun, Fuqiang Gao, Liming Cheng, Zirong Li
Despite the wide use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in bone defect, its application in treating osteonecrosis of femoral head (ONFH) is yet to be elucidated. The heterotopic ossification (HO) after rhBMP-2 usage in some orthopedic surgeries has been reported previously; however, only a few studies describe this complication in the treatment of ONFH.The present study investigated whether the rhBMP-2 application would increase the risk of HO formation in selected ONFH patients with nonvascularized bone grafting surgery and enhance the surgical results of nonvascularized bone grafting as compared to patients who did not receive intraoperative rhBMP-2...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28634093/total-hip-arthroplasty-after-transtrochanteric-rotational-osteotomy-for-osteonecrosis-of-the-femoral-head-a-mean-10-year-follow-up
#14
Yusuke Osawa, Taisuke Seki, Daigo Morita, Yasuhiko Takegami, Toshiaki Okura, Naoki Ishiguro
BACKGROUND: The objective of the present study was to investigate clinical, quality of life, and radiographic outcomes of patients who underwent total hip arthroplasty (THA) after transtrochanteric rotational osteotomy (TRO) for osteonecrosis of the femoral head (ONFH). METHODS: We performed a case-control study. The participants were 29 patients (34 hips) who underwent THA after TRO (TRO group). These patients had a mean age at surgery of 51.6 years (range, 30-72 years) and underwent postoperative follow-up for a mean period of 10...
May 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28623889/surgical-accuracy-function-and-quality-of-life-of-simultaneous-versus-staged-bilateral-total-hip-arthroplasty-in-patients-with-osteonecrosis-of-the-femoral-head
#15
Seung-Chan Kim, Young-Wook Lim, Woo-Lam Jo, Dong-Chul Park, Jin-Woo Lee, Won-Woo Kang, Yong-Sik Kim
BACKGROUND: The optimal surgical option for patients requiring bilateral hip replacement remains controversial. The purpose of this study was to compare surgical accuracy; functional outcome and health-related quality of life; and prosthetic-related complications and revision surgery of a simultaneous bilateral total hip arthroplasty (THA) with those of a staged bilateral THA with an interval between procedures <12 months. METHODS: A total of 123 unselected consecutive patients (mean age, 43...
June 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28574127/influence-of-cigarette-smoking-on-osteonecrosis-of-the-femoral-head-onfh-a-systematic-review-and-meta-analysis
#16
Zhenxing Wen, Zan Lin, Wenlong Yan, Jian Zhang
BACKGROUND: Current studies demonstrate controversy regarding the relationship between cigarette smoking and osteonecrosis of the femoral head (ONFH). METHODS: We conducted a meta-analysis to evaluate the association between smoking and ONFH. Relevant articles published before September 2016 were identified by a systematic search of EMBASE and MEDLINE via Ovid. Summary odds ratios (OR) were calculated using random effects models, and study quality was assessed using a modified Newcastle-Ottawa scale...
May 29, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28540628/effect-of-collapse-on-the-deformity-of-the-femoral-head-neck-junction-in-osteonecrosis-of-the-femoral-head
#17
Yusuke Kubo, Goro Motomura, Satoshi Ikemura, Kazuhiko Sonoda, Takuaki Yamamoto, Yasuharu Nakashima
INTRODUCTION: The purpose of this study was to morphologically assess the effect of collapse on the deformity of the femoral head-neck junction in patients with nontraumatic osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS: From January 2005 through March 2016, magnetic resonance (MR) imaging including the oblique view was repeatedly performed before and after collapse in 24 hips of patients with ONFH (16 men, 8 women; mean age 43 years; range 23-68 years), that were the subjects of this study...
May 24, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28539248/percutaneously-drilling-through-femoral-head-and-neck-fenestration-combining-with-compacted-autograft-for-early-femoral-head-necrosis-a-retrospective-study
#18
Donghai Li, Xiaowei Xie, Pengde Kang, Bin Shen, Fuxing Pei, Changde Wang
BACKGROUND: The purpose of this study was to evaluate the clinical results, survivorship and quick rehabilitation effects of modified surgery of percutaneously drilling and decompression through femoral head and neck fenestration combined with compacted autograft for early femoral head necrosis. METHODS: We conducted a retrospective cohort study with 83 hips performed percutaneous decompression through femoral head and neck fenestration (Modified group) combined with autogenous bone grafting for early ONFH...
May 21, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28529456/ethyl-acetate-fraction-of-huogu-formula-inhibits-adipogenic-differentiation-of-bone-marrow-stromal-cells-via-the-bmp-and-wnt-signaling-pathways
#19
Xiangying Kong, Xiaomin Li, Cun Zhang, Liuluan Zhu, Chunfang Liu, Qingxia Qin, Cuiling Liu, Qianqian Wang, Jia Zhu, Xuan Wu, Hongye Wan, Weiheng Chen, Na Lin
Elevated adipogenesis of bone marrow stromal cells (BMSCs) is closely associated with non-traumatic osteonecrosis of femoral head (ONFH). Our previous studies have shown that Huogu (HG) formula was effective both in clinic experience and experimental ONFH. How HG impacts the differentiation of BMSCs and what is the underlying molecular mechanism remain largely unknown. Our results showed that ethyl acetate extract of HG (HGE) significantly decreased the adipocyte differentiation as determined by oil red staining, while slightly increased the ALP activity...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28529111/the-results-of-total-hip-arthroplasty-after-sugioka-transtrochanteric-anterior-rotational-osteotomy-for-osteonecrosis
#20
Takeshi Utsunomiya, Goro Motomura, Satoshi Ikemura, Satoshi Hamai, Jun-Ichi Fukushi, Yasuharu Nakashima
BACKGROUND: Since Sugioka transtrochanteric anterior rotational osteotomy (ARO) for osteonecrosis of the femoral head (ONFH) changes the morphology of the proximal femur, total hip arthroplasty (THA) after previous ARO is considered a technically demanding procedure. The purpose of this study was to compare the clinicoradiologic outcomes of THA after ARO with those of THA without any antecedent surgery for ONFH. METHODS: Twenty-four hips in 20 patients who underwent cementless THA after ARO (postosteotomy group) were retrospectively reviewed and compared with patients who underwent cementless THA without any antecedent surgery for ONFH during the same period (primary group)...
April 27, 2017: Journal of Arthroplasty
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