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https://www.readbyqxmd.com/read/27912962/the-influence-of-traditional-chinese-medicine-constitutions-on-the-potential-repair-capacity-after-osteonecrosis-of-the-femoral-head
#1
Tong Yu, Zhennan Zhang, Limin Xie, Xun Ke, Yang Liu
OBJECTIVES: To explore the effects of traditional Chinese medicine (TCM) constitutions on repair capacity after osteonecrosis of the femoral head (ONFH). DESIGN AND SETTING: Ninety-six patients with TCM constitutions of yang-deficiency, dampness-heat and/or blood-stasis were recruited from the orthopedic outpatient clinic of the Guang'anmen Hospital of the China Academy of Chinese Medical Science. Each patient underwent computed tomography (CT) examination of the hips, and CAD software was used to estimate proximal sclerosis ratios based on the CT images...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27910957/mir-27a-attenuates-adipogenesis-and-promotes-osteogenesis-in-steroid-induced-rat-bmscs-by-targeting-ppar%C3%AE-and-grem1
#2
Chenxi Gu, Yan Xu, Shanfeng Zhang, Hongya Guan, Shi Song, Xiuli Wang, Yisheng Wang, Yuebai Li, Guoqiang Zhao
The imbalance between adipogenic and osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs) plays a significant role in the pathogenesis of steroid-induced osteonecrosis of the femoral head (ONFH). Several microRNAs (miRNAs) are involved in regulating adipogenesis and osteogenesis. In this study, we established a steroid-induced ONFH rat model to identify the potential relevant miRNAs. We identified 9 up-regulated and 28 down-regulated miRNAs in the ONFH rat model. Of these, miR-27a was down-regulated and negatively correlated with peroxisome proliferator-activated receptor gamma (PPARγ) and gremlin 1 (GREM1) expression...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904218/core-decompression-or-quadratus-femoris-muscle-pedicle-bone-grafting-for-nontraumatic-osteonecrosis-of-the-femoral-head-a-randomized-control-study
#3
Deqiang Li, Ming Li, Peilai Liu, Yuankai Zhang, Liang Ma, Fei Xu
BACKGROUND: The traditional management for osteonecrosis of the femoral head (ONFH) includes core decompression (CD) and quadratus femoris muscle pedicle bone graft (QF-MPBG). The aim of this study was to investigate the effects of CD and QF-MPBG on the patients with nontraumatic ONFH in an early stage. MATERIALS AND METHODS: 39 patients (47 hips) with ONFH in an early stage (Ficat Stage I or II) were randomly divided into two groups according to random number table method...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27888294/total-hip-arthroplasty-with-dual-mobility-cup-in-osteonecrosis-of-the-femoral-head-in-young-patients-over-ten-years-of-follow-up
#4
Pierre Martz, Alexandre Maczynski, Sebastien Elsair, Ludovic Labattut, Brice Viard, Emmanuel Baulot
Osteonecrosis of the femoral head affects mainly young patients with high functional needs this increases the risk of dislocation. Dual mobility cups known for low rate of dislocation and high mobility range seems indicated. We evaluate functional efficiency, survival and dislocation rate of dual mobility cup for total hip arthroplasty for osteonecrosis in young patients. Monocentric retrospective clinical study, from 2000 to 2008. With a clinical analysis in pre-operative and over ten years of follow-up of one cohort of patients under 55 years old with an indication of THA for ONFH...
November 25, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27882161/potential-diagnostic-role-of-diffusion-tensor-imaging-in-early-stage-osteonecrosis-of-the-femoral-head
#5
Hongwei Min, Feng Xu, Rui Gu, Xinzuo Han, Anqing Wang, Kemin Liu
The present study aimed to explore the potential diagnostic role of diffusion tensor magnetic resonance imaging (DTI) in the early stage of modified corticosteroid-induced osteonecrosis of the femoral head (ONFH). A total of 20 beagles were randomly classified (1:1) into either an experimental group (LM), which were intramuscularly injected with lipopolysaccharide (LPS) and methylprednisolone (MPS) on three consecutive days, or control (CON) group, which were injected with saline. Magnetic resonance imaging (MRI) and DTI were performed at pre-induction and 8 and 12 weeks post-induction...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882083/dimethyloxaloylglycine-increases-bone-repair-capacity-of-adipose-derived-stem-cells-in-the-treatment-of-osteonecrosis-of-the-femoral-head
#6
Zhen-Hong Zhu, Wen-Qi Song, Chang-Qing Zhang, Ji-Min Yin
Mesenchymal stem cells have been widely studied to promote local bone regeneration of osteonecrosis of the femoral head (ONFH). Previous studies observed that dimethyloxaloylglycine (DMOG) enhanced the angiogenic and osteogenic activity of mesenchymal stem cells by activating the expression of hypoxia inducible factor-1α (HIF-1α), thereby improving the bone repair capacity of mesenchymal stem cells. In the present study, it was investigated whether DMOG could increase the bone repair capacity of adipose-derived stem cells (ASCs) in the treatment of ONFH...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27858915/genetic-polymorphisms-of-cyp3a4-among-chinese-patients-with-steroid-induced-osteonecrosis-of-the-femoral-head
#7
Yuan Wang, Xiuling Li, Yaoyu Gao, Zhi Li, Lidong Yu, Qingbo Meng, Li Sun, Jianzhong Wang
BACKGROUND: Steroid therapy has been an important reason of nontraumatic osteonecrosis of the femoral head (ONFH). Steroids are metabolized by hepatic cytochrome P4503A, a low endogenous activity of this enzyme can contribute to the pathogenesis of ONFH. The aim of this study was to investigate the associations of polymorphisms of cytochrome P4503A4 (CYP3A4) gene with steroid-induced ONFH in Chinese patients. METHODS: A total of 150 steroid-induced ONFH patients and 250 healthy controls were enrolled...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27833839/patient-reported-outcomes-of-femoral-osteotomy-and-total-hip-arthroplasty-for-osteonecrosis-of-the-femoral-head-a-prospective-case-series-study
#8
Yusuke Kubo, Takuaki Yamamoto, Goro Motomura, Kazuyuki Karasuyama, Kazuhiko Sonoda, Yukihide Iwamoto
BACKGROUND: Patient-reported scoring systems have recently been used after surgical procedures. The purpose of this prospective study was to evaluate the patient-reported outcomes of femoral osteotomy and total hip arthroplasty (THA) for osteonecrosis of the femoral head (ONFH). METHODS: Forty-two symptomatic ONFH patients with asymptomatic contralateral hip underwent either transtrochanteric anterior rotational osteotomy (ARO) or THA as a primary operation. Of these, 20 patients whose contralateral hips remained asymptomatic at the final follow-up (more than 1 year postoperatively) were recruited to participate in this study...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27826791/rational-derivation-extension-and-cyclization-of-self-inhibitory-peptides-to-target-tgf-%C3%AE-bmp-signaling-in-onfh
#9
Zhenhong Zhu, Chi Zhang, Wenqi Song
The human transforming growth factor β (TGF-β)/bone morphogenic protein (BMP) signaling has been recognized as an attractive target to suppress fibroblast activation in osteonecrosis of the femoral head (ONFH). Here, we reported successful derivation of a self-inhibitory peptide from the crystal complex interface of TGF-β with its cognate receptor TβRI using rational molecular design and in vitro binding assay. Computational modeling suggested that the peptide possesses a large flexibility and would incur considerable entropy penalty...
November 9, 2016: Amino Acids
https://www.readbyqxmd.com/read/27779162/local-administration-of-bisphosphonate-soaked-hydroxyapatite-for-the-treatment-of-osteonecrosis-of-the-femoral-head-in-rabbit
#10
Jin-Hui Ma, Wan-Shou Guo, Zi-Rong Li, Bai-Liang Wang
BACKGROUND: Systemic administration of bisphosphonates has shown promising results in the treatment of osteonecrosis of the femoral head (ONFH). However, few studies have evaluated the efficacy of local zoledronate (ZOL) administration in the treatment of ONFH. The purpose of this study was to investigate whether local administration of bisphosphonate-soaked hydroxyapatite (HA) could improve bone healing in an experimental rabbit model of ONFH. METHODS: This experimental study was conducted between October 2014 and June 2015...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27766040/exosomes-from-human-synovial-derived-mesenchymal-stem-cells-prevent-glucocorticoid-induced-osteonecrosis-of-the-femoral-head-in-the-rat
#11
Shang-Chun Guo, Shi-Cong Tao, Wen-Jing Yin, Xin Qi, Jia-Gen Sheng, Chang-Qing Zhang
Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies indicate the transplanted cells exert therapeutic effects primarily via a paracrine mechanism and exosomes are an important paracrine factor that can be directly used as therapeutic agents for tissue engineering...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27755641/radiologic-and-clinical-features-of-misdiagnosed-idiopathic-osteonecrosis-of-the-femoral-head
#12
Wataru Ando, Kengo Yamamoto, Tsuyoshi Koyama, Yoshichika Hashimoto, Takashi Tsujimoto, Kenji Ohzono
Idiopathic osteonecrosis of the femoral head (ONFH) can be correctly diagnosed in accordance with the established criteria. However, some general orthopedic physicians have misdiagnosed patients as having ONFH. The goal of this study was to clarify the radiologic and clinical features of misdiagnosed patients. This study included 50 patients who were referred to the authors' hospital by general physicians with a diagnosis of ONFH. The correct diagnosis was made based on the Japanese Investigation Committee diagnostic criteria for ONFH...
October 18, 2016: Orthopedics
https://www.readbyqxmd.com/read/27704894/associations-of-igfbp3-gene-polymorphism-and-gene-expression-with-the-risk-of-osteonecrosis-of-the-femoral-head-in-a-han-population-in-northern-china
#13
Yang Song, Zhenwu Du, Qiwei Yang, Ming Ren, Yujie Sui, Qingyu Wang, Ao Wang, Haiyue Zhao, Jincheng Wang, Guizhen Zhang
The critical roles of IGFBP3 in regulating the osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells strongly indicate its potential effects on the pathogenesis of osteonecrosis of the femoral head (ONFH). In this study, we investigated the association of IGFBP3 gene polymorphism and its protein expression with the development of ONFH to further explore its molecular pathogenesis. Ligase detection reactions and enzyme-linked immunosorbent assay were used to detect the polymorphisms of rs2453839[C/T] and rs3110697[A/G] and the serum protein expression of IGFBP3 gene in 182 cases and 179 controls, respectively...
October 5, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27703421/treatment-of-pre-collapse-stages-of-osteonecrosis-of-the-femoral-head-a-systematic-review-of-randomized-control-trials
#14
REVIEW
Jordan C Villa, Solomon Husain, Jelle P van der List, Arianna Gianakos, Joseph M Lane
BACKGROUND: Treatment for osteonecrosis of the femoral head (ONFH) remains controversial. Current reviews include low-level evidence studies evaluating the treatment of both pre-collapse and collapse stages of the disease. QUESTIONS/PURPOSES: The purpose of the current study is to systematically review the literature evaluating core decompression (CD) with bone marrow mesenchymal cells (BMMCs), CD alone, and bisphosphonate treatment in pre-collapse ONFH by focusing just on randomized clinical trials (RCTs) reporting functional and radiologic outcomes...
October 2016: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/27664561/dosage-effects-of-extracorporeal-shockwave-therapy-in-early-hip-necrosis
#15
Ching-Jen Wang, Chung-Cheng Huang, Hon-Kan Yip, Ya-Ju Yang
BACKGROUND: This study investigated the effects of different dosages of extracorporeal shockwave therapy (ESWT) in early osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS: Thirty-three patients (42 hips) were randomly divided into three groups. Group A (10 patients with 16 hips) received 2000 impulses of ESWT at 24 Kv to the affected hip. Group B (11 patients with 14 hips) and Group C (12 patients with 12 hips) received 4000 and 6000 impulses of ESWT respectively...
September 21, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27648614/necrotic-bone-stimulates-proinflammatory-responses-in-macrophages-through-the-activation-of-toll-like-receptor-4
#16
Naga Suresh Adapala, Ryosuke Yamaguchi, Matthew Phipps, Olumide Aruwajoye, Harry K W Kim
In children with Legg-Calvé-Perthes disease, loss of blood supply to the femoral head results in ischemic osteonecrosis. Generally, macrophages play important roles in the inflammatory response to tissue necrosis, but their role in ischemic osteonecrosis of the femoral head (ONFH) is not known. The purpose of this study was to determine the macrophage-inflammatory responses after ONFH and the receptor mechanisms involved in sensing the necrotic bone, using a piglet model of Legg-Calvé-Perthes disease. Induction of ONFH resulted in increased numbers of CD14(+) macrophages (4...
September 17, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27637086/a-single-nucleotide-polymorphism-in-mmp9-is-associated-with-decreased-risk-of-steroid-induced-osteonecrosis-of-the-femoral-head
#17
Jieli Du, Wanlin Liu, Tianbo Jin, Zhenqun Zhao, Rui Bai, Huiqin Xue, Junyu Chen, Mingqi Sun, Xiyang Zhang, Guoqiang Wang, Jianzhong Wang
Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations...
September 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27634376/efficacy-of-umbilical-cord-derived-mesenchymal-stem-cell-based-therapy-for-osteonecrosis-of-the-femoral-head-a-three-year-follow-up-study
#18
Chun Chen, Zhiguo Qu, Xiaoguang Yin, Chunyu Shang, Qiang Ao, Yongquan Gu, Ying Liu
This is a retrospective analysis of the clinical effects of transplant of mesenchymal stem cells (MSCs) derived from human umbilical cord-derived MSCs (hUC‑MSCs) for the treatment of osteonecrosis of the femoral head (ONFH). The biological characteristics of hUC-MSCs were assessed using flow cytometry. Nine eligible patients were enrolled in the study as they adhered to the Association Research Circulation Osseous (ARCO) classification of stage Ⅱ‑Ⅲa, and hUC‑MSCs were grafted by intra‑arterial infusion...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27631232/association-between-genetic-polymorphisms-of-mmp8-and-the-risk-of-steroid-induced-osteonecrosis-of-the-femoral-head-in-the-population-of-northern-china
#19
Jieli Du, Tianbo Jin, Yuju Cao, Junyu Chen, Yongchang Guo, Mingqi Sun, Jian Li, Xiyang Zhang, Guoqiang Wang, Jianzhong Wang
BACKGROUND: Steroid-induced osteonecrosis of the femoral head (ONFH) is the most common clinical nontraumatic ONFH. Once ONFH occurs, it seriously reduces patients' quality of life. The matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP) system was found to play a significant role in the development of ONFH. The aim of this study was to identify the associations between 7 genes selected from the MMP/TIMP system and steroid-induced ONFH. METHODS: We genotyped 34 single-nucleotide polymorphisms (SNPs) of 7 genes selected from the MMP/TIMP system in a case-control study with 285 cases of steroid-induced ONFH and 308 healthy controls...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27573979/what-factors-predict-the-failure-of-curved-intertrochanteric-varus-osteotomy-for-the-osteonecrosis-of-the-femoral-head
#20
Toshiaki Okura, Yukiharu Hasegawa, Daigo Morita, Yusuke Osawa, Naoki Ishiguro
INTRODUCTION: The purpose of this study was to examine the 10-year survivorship and clinical outcome after curved intertrochanteric varus osteotomy (CVO) for the osteonecrosis of the femoral head (ONFH), and to determine what factors predict the failure of this procedure. MATERIALS AND METHODS: We retrospectively reviewed 102 consecutive CVOs in 93 patients diagnosed with ONFH. Mean follow-up duration was 10.1 years (3.0-23.2 years). Factors associated with radiographic failure (secondary collapse and/or osteoarthritic change), conversion to total hip arthroplasty (THA) and low Harris Hip Score (HHS), were assessed...
August 29, 2016: Archives of Orthopaedic and Trauma Surgery
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