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https://www.readbyqxmd.com/read/28423488/mmp8-polymorphism-is-associated-with-susceptibility-to-osteonecrosis-of-the-femoral-head-in-a-chinese-han-population
#1
Feimeng An, Jieli Du, Yuju Cao, Jianping Shi, Yongchang Guo, Tianbo Jin, Jian Li, Junyu Chen, Ping Li, Mei Dong, Guoqiang Wang, Jianzhong Wang
Osteonecrosis of the femoral head (ONFH) is an orthopedic refractory disease that adversely affects quality of life. Matrix metalloproteinase-8 (MMP-8) produced by the bone marrow has been implicated in the degradation of collagen during bone development. We assessed whether MMP8 polymorphisms are associated with ONFH. In a case-control study, using χ2 tests and genetic model analyses, we genotyped 5 MMP8 single-nucleotide polymorphisms (SNPs) in 585 ONFH patients and 507 healthy control subjects in a Chinese Han population...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422866/the-use-of-anticoagulants-for-prevention-and-treatment-of-osteonecrosis-of-the-femoral-head-a-systematic-review
#2
Peipei Guo, Fuqiang Gao, Yanhua Wang, Zhenkun Zhang, Wei Sun, Baoguo Jiang, Bailiang Wang, Zirong Li
BACKGROUND: Osteonecrosis of the femoral head (ONFH) is a progressive disease, which mainly affects young adults and often necessitates total hip arthroplasty (THA), so early interventions are critical to successfully protect hip joint from THA. In this review, our purpose was to determine the effects of anticoagulants for preventing and treating the primary and secondary ONFH, respectively, before the collapse stage or before the pathology of necrosis. METHODS: We searched PubMed, Embase, Web of Science databases for relevant studies...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422712/combination-analysis-of-nos3-abcb1-and-il23r-polymorphisms-with-alcohol-induced-osteonecrosis-of-the-femoral-head-risk-in-chinese-males
#3
Yuan Wang, Xuejun Yang, Jianping Shi, Yan Zhao, Linlin Pan, Jinqiu Zhou, Guoqiang Wang, Jianzhong Wang
BACKGROUND: Common variants of multiple genes played a crucial role in osteonecrosis of the femoral head (ONFH) onset which was proved by many previous reports. We hypothesized that polymorphisms in NOS3, ABCB1 and IL23R were related to individual differences in alcohol sensitivity and the development of alcohol-induced ONFH. METHODS: In this case-control study, we evaluated 8 SNPs in three genes in the Chinese Han population including 355 male cases and 355 healthy male controls...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415829/association-between-alcohol-induced-osteonecrosis-of-femoral-head-and-risk-variants-of-mmps-in-han-population-based-on-a-case-control-study
#4
Jianzhong Wang, Xugang Shi, Hua Yang, Jieli Du, Yongri Ouyang, Hong Wang, Tianbo Jin, Chao Chen
The study aimed to evaluate the association between MMP gene superfamily and alcohol-induced osteonecrosis of femoral head (alcohol-induced ONFH) risk given its high prevalence, poor therapeutic effect, and serious clinical prognosis. 308 subjects (mean age, 49.47 years; males, 64.0%) who participated in our control group and 300 alcohol-induced ONFH patients (mean age, 43.29 years; males, 99.7%) formed the case group was enrolled to estimate by statistical analysis. We selected 23 single nucleotide polymorphisms (SNPs) from MMPs, and performed the chi-squared test, Fisher's exact test, t-test and genetic model analyses...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415692/novel-akt-activator-sc-79-is-a-potential-treatment-for-alcohol-induced-osteonecrosis-of-the-femoral-head
#5
Yi-Xuan Chen, Shi-Cong Tao, Zheng-Liang Xu, Wen-Jing Yin, Yue-Lei Zhang, Jun-Hui Yin, You-Shui Gao, Chang-Qing Zhang
Alcohol is a leading risk factor for osteonecrosis of the femoral head (ONFH). We explored the molecular mechanisms underlying alcohol-induced ONFH and investigated the protective effect of the novel Akt activator SC-79 against this disease. We found that ethanol inhibited expression of the osteogenic genes RUNX2 and OCN, downregulated osteogenic differentiation, impaired the recruitment of Akt to the plasma membrane, and suppressed Akt phosphorylation at Ser473, thereby inhibiting the Akt/GSK3β/β-catenin signaling pathway in bone mesenchymal stem cells...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28392136/analysis-of-cell-therapies-used-in-clinical-trials-for-the-treatment-of-osteonecrosis-of-the-femoral-head-a-systematic-review-of-the-literature
#6
REVIEW
Nicolas S Piuzzi, Jorge Chahla, Hao Jiandong, Morad Chughtai, Robert F LaPrade, Michael A Mont, George F Muschler, Cecilia Pascual-Garrido
BACKGROUND: Osteonecrosis of the femoral head (ONFH) is associated with regional loss of cells within bone, often resulting in pain and mechanical collapse. Our purpose was to analyze the cell-therapies used in clinical trials for the treatment of ONFH with regard to (1) cell-sources, (2) collection techniques, (3) cell-processing, (4) qualitative and quantitative characterizations, and (5) delivery methods. METHODS: A systematic review of the current literature on the use of cell therapies for the treatment of ONFH was performed...
March 15, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28386565/a-10-year-follow-up-of-two-incision-and-modified-watson-jones-total-hip-arthroplasty-in-patients-with-osteonecrosis-of-the-femoral-head
#7
Shih-Jie Lin, Tsan-Wen Huang, Po-Chun Lin, Feng-Chih Kuo, Kuo-Ti Peng, Kuo-Chin Huang, Mel S Lee
Long-term data and information indicating whether minimally invasive surgery (MIS) approaches are safe and effective with total hip arthroplasty (THA) are lacking. Between 2004 and 2006, 75 patients with alcohol-related osteonecrosis of the femoral head (ONFH) who underwent 75 THAs with the two-incision approach were studied. The medical records, radiographic parameters, and functional outcomes were collected prospectively. All data were compared with those for matched patients who underwent a modified Watson-Jones (WJ) approach...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28371498/chinese-guideline-for-the-diagnosis-and-treatment-of-osteonecrosis-of-the-femoral-head-in-adults
#8
(no author information available yet)
The treatment of adult osteonecrosis of the femoral head (ONFH), with 8.12 million patients in China, remains a challenge to surgeons. To standardize and improve the efficacy of the treatment of ONFH, Chinese specialists updated the experts' suggestions in March 2015, and an experts' consensus was given to provide a current basis for the diagnosis, treatment and evaluation of ONFH. The current guideline provides recommendations for ONFH with respect to epidemiology, etiology, diagnostic criteria, differential diagnosis, staging, treatment, as well as rehabilitation...
February 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28256626/treatment-of-steroid-induced-osteonecrosis-of-the-femoral-head-using-porous-se-sio2-nanocomposites-to-suppress-reactive-oxygen-species
#9
Guoying Deng, Kerun Niu, Feng Zhou, Buxiao Li, Yingjie Kang, Xijian Liu, Junqing Hu, Bo Li, Qiugen Wang, Chengqing Yi, Qian Wang
Reducing oxidative stress (ROS) have been demonstrated effective for steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH). Selenium (Se) plays an important role in suppressing oxidative stress and has huge potential in ONFH treatments. However the Se has a narrow margin between beneficial and toxic effects which make it hard for therapy use in vivo. In order to make the deficiency up, a control release of Se (Se@SiO2) were realized by nanotechnology modification. Porous Se@SiO2 nanocomposites have favorable biocompatibility and can reduced the ROS damage effectively...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28255363/exosomes-derived-from-human-platelet-rich-plasma-prevent-apoptosis-induced-by-glucocorticoid-associated-endoplasmic-reticulum-stress-in-rat-osteonecrosis-of-the-femoral-head-via-the-akt-bad-bcl-2-signal-pathway
#10
Shi-Cong Tao, Ting Yuan, Bi-Yu Rui, Zhen-Zhong Zhu, Shang-Chun Guo, Chang-Qing Zhang
An excess of glucocorticoids (GCs) is reported to be one of the most common causes of osteonecrosis of the femoral head (ONFH). In addition, GCs can induce bone cell apoptosis through modulating endoplasmic reticulum (ER) stress. Among the three main signal pathways in ER stress, the PERK (protein kinase RNA-like ER kinase)/CHOP (CCAAT-enhancer-binding protein homologous protein) pathway has been considered to be closely associated with apoptosis. Platelet-rich plasma (PRP) has been referred to as a concentration of growth factors and the exosomes derived from PRP (PRP-Exos) have a similar effect to their parent material...
2017: Theranostics
https://www.readbyqxmd.com/read/28255275/exosomes-secreted-from-human-induced-pluripotent-stem-cell-derived-mesenchymal-stem-cells-prevent-osteonecrosis-of-the-femoral-head-by-promoting-angiogenesis
#11
Xiaolin Liu, Qing Li, Xin Niu, Bin Hu, Shengbao Chen, Wenqi Song, Jian Ding, Changqing Zhang, Yang Wang
Background: Local ischemia is the main pathological performance in osteonecrosis of the femoral head (ONFH). There is currently no effective therapy to promote angiogenesis in the femoral head. Recent studies revealed that exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSC-Exos) have great therapeutic potential in ischemic tissues, but whether they could promote angiogenesis in ONFH has not been reported, and little is known regarding the underlying mechanism. Methods: iPS-MSC-Exos were intravenously injected to a steroid-induced rat osteonecrosis model...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28251470/3d-printed-porous-titanium-changed-femoral-head-repair-growth-patterns-osteogenesis-and-vascularisation-in-porous-titanium
#12
Wei Zhu, Yan Zhao, Qi Ma, Yingjie Wang, Zhihong Wu, Xisheng Weng
Osteonecrosis of the femoral head (ONFH) is a major cause of morbidity, and total hip arthroplasty is both traumatic and expensive. Here, we created a gelatine scaffold embedded in uniquely shaped, 3D-printed porous titanium parts, which could attract and promote the proliferation of osteoblasts as well as bone regeneration, as the extracellular matrix (ECM) does in vivo. Interestingly, after hybridisation with platelets, the scaffold exhibited a low yet considerable rate of stable, safe and long-term growth factor release...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28247166/progranulin-protects-against-osteonecrosis-of-the-femoral-head-by-activating-erk1-2-pathway
#13
Yingguang Han, Meng Si, Yunpeng Zhao, Yi Liu, Kaiyuan Cheng, Yuedong Zhang, Jialin Jia, Jingkun Li, Lin Nie
The aim of this study was to investigate progranulin (PGRN) expression and its effect in cartilage degradation and in the pathogenesis of osteonecrosis of the femoral head (ONFH). Cartilage specimens were obtained from ONFH and FNF patients and PGRN expression was analyzed by immunohistochemistry, western blot analysis, and RT-PCR. Peripheral blood PGRN level was detected by ELISA. Additionally, primary chondrocytes were cultured and treated with PGRN. Next, the expression of aggrecan and collagen II and the activation of ERK1/2 were detected...
February 28, 2017: Inflammation
https://www.readbyqxmd.com/read/28207735/long-non-coding-rna-hotair-inhibits-mir-17-5p-to-regulate-osteogenic-differentiation-and-proliferation-in-non-traumatic-osteonecrosis-of-femoral-head
#14
Biaofang Wei, Wei Wei, Baoxiang Zhao, Xiaxia Guo, Song Liu
BACKGROUND AND AIM: The biological functions of non-coding RNAs (ncRNAs) have been widely identified in many human diseases. In the present study, the relationship between long non-coding RNA HOTAIR and microRNA-17-5p (miR-17-5p) and their roles in osteogenic differentiation and proliferation in non-traumatic osteonecrosis of femoral head (ONFH) were investigated. METHODS: The expression levels of HOTAIR and miR-17-5p in the mesenchymal stem cells (MSCs) derived from patients with non-traumatic ONFH and osteoarthritis (OA) were examined by real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/28167850/hip-osteonecrosis-is-associated-with-increased-plasma-il-33-level
#15
Jinhui Ma, Wanshou Guo, Zirong Li, Bailiang Wang, Shirui Li, Peng Wang
The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass index- (BMI-) matched healthy subjects were included in this prospective study between March 2016 and September 2016. A commercially available ELISA kit was used to test the level of plasma IL-33...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28162838/evidence-for-the-use-of-cell-based-therapy-for-the-treatment-of-osteonecrosis-of-the-femoral-head-a-systematic-review-of-the-literature
#16
Nicolas S Piuzzi, Jorge Chahla, John B Schrock, Robert F LaPrade, Cecilia Pascual-Garrido, Michael A Mont, George F Muschler
BACKGROUND: Cell-therapy has been promoted among the therapeutic arsenal that can aid in bone formation and remodeling, in early stages of osteonecrosis of the femoral head (ONFH). The purpose of this systematic review was to assess the evidence supporting the (1) clinical efficacy; (2) structural modifying effect, as evaluated radiographically; (3) revision rates; and (4) safety of cell-therapy for the treatment of ONFH. METHODS: A systematic review was performed including studies with a level-of-evidence of III or higher...
January 12, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28148658/long-term-outcomes-of-transtrochanteric-rotational-osteotomy-for-non-traumatic-osteonecrosis-of-the-femoral-head
#17
D Morita, Y Hasegawa, T Okura, Y Osawa, N Ishiguro
AIMS: Transtrochanteric rotational osteotomy (TRO) is performed for young patients with non-traumatic osteonecrosis of the femoral head (ONFH) to preserve the hip. We aimed to investigate the long-term outcomes and the risk factors for failure 15 years after this procedure. PATIENTS AND METHODS: This study included 95 patients (111 hips) with a mean age of 40 years (21 to 64) who underwent TRO for ONFH. The mean follow-up was 18.2 years (3 to 26). Kaplan-Meier survivorship analyses were performed with conversion to total hip arthroplasty (THA) and radiological failure due to secondary collapse of the femoral head or osteoarthritic changes as the endpoint...
February 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28121934/extracorporeal-shockwave-therapy-in-osteonecrosis-of-femoral-head-a-systematic-review-of-now-available-clinical-evidences
#18
REVIEW
Qingyu Zhang, Lihua Liu, Wei Sun, Fuqiang Gao, Liming Cheng, Zirong Li
BACKGROUND: Osteonecrosis is an incapacitating disorder with high morbidity. Though extracorporeal shockwave therapy (ESWT) provides a noninvasive treatment option, controversial subjects still exist about its effectiveness, indications, and mechanism of action. METHODS: An electronic databases search was performed using PubMed, Embase, and the Cochrane library to collect clinical trials, case reports, and cases series on this topic and then useful data were extracted and appraised by experienced clinicians...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28108757/degeneration-of-articular-cartilage-in-osteonecrosis-of-the-femoral-head-begins-at-the-necrotic-region-after-collapse-a-preliminary-study-using-t1-rho-mri
#19
Kazuhiko Sonoda, Goro Motomura, Satoshi Kawanami, Yukihisa Takayama, Hiroshi Honda, Takuaki Yamamoto, Yasuharu Nakashima
OBJECTIVE: The purpose of this study is to evaluate the role of collapse on the degeneration of articular cartilage in patients with osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS: Sixteen hips in 12 patients (four men, eight women; mean age, 34.8 years) with a history of systemic corticosteroid treatment were studied using T1 rho magnetic resonance imaging (MRI). Six hips had collapsed ONFH, five had non-collapsed ONFH, and five had no osteonecrosis (controls)...
January 21, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28106233/a-novel-digital-templating-methodology-for-arthroplasty-experience-from-patients-with-osteonecrosis-of-the-femoral-head
#20
Ning Dong, Chen Yang, Shu-Qiang Li, Yu-Hang Gao, Jian-Guo Liu, Xin Qi
PURPOSE: To assess the accuracy of a novel digital templating methodology for total hip arthroplasty (THA) in patients with osteonecrosis of the femoral head (ONFH). METHODS: A retrospective study was carried out on 77 hips in 58 patients who had undergone uncemented THA for ONFH. Preoperative radiographs were templated using a 2-step procedure: (i) calculation of basic cup and stem sizes based on the anatomical morphology; (ii) adjustment of the basic sizes to account for variables such as femoral external rotation, osteoporotic changes in the femur, osteosclerotic changes in the acetabulum, and the type of stem...
January 20, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
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