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https://www.readbyqxmd.com/read/28017874/factors-influencing-progressive-collapse-of-the-transposed-necrotic-lesion-after-transtrochanteric-anterior-rotational-osteotomy-for-osteonecrosis-of-the-femoral-head
#1
Yusuke Kubo, Goro Motomura, Satoshi Ikemura, Kazuhiko Sonoda, Takuaki Yamamoto, Yasuharu Nakashima
BACKGROUND: Transtrochanteric anterior rotational osteotomy (ARO) for osteonecrosis of the femoral head (ONFH) can preserve for a long-time collapsed femoral head. Progressive collapse of anteriorly-transposed necrotic lesion leads to secondary arthritic changes and clinical failure. Critical factors influencing collapse of the transposed necrotic lesion after ARO remain largely unknown. Therefore we performed a retrospective study of ARO to determine: 1) if pre-operative collapse influences collapse of the transposed necrotic area, 2) if any other factor may influence collapse of the transposed necrotic area...
December 22, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28009135/diagnostics-of-femoral-head-status-in-humans-using-laser-spectroscopy-in-vitro-studies
#2
Huiying Lin, Wansha Li, Hao Zhang, Peng Chen, Delong Chen, Wei He, Sune Svanberg, Katarina Svanberg
Osteonecrosis of the femoral head (ONFH), a recalcitrant and disabling disease, is caused by inadequate or fully disrupted blood supply to the affected segment of the subchondral bone. Theoretically, there will develop gas-filled pores during the bone decay process due to lacking blood supply. Unfortunately, the relationship between the gas-filled pores and ONFH is still unclear. Here, we have introduced diode laser absorption spectroscopy to detect oxygen and water vapor signals in the femoral heads from hip replacement in 19 patients...
December 23, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/28000841/genome-wide-association-scans-for-idiopathic-osteonecrosis-of-the-femoral-head-in-a-korean-population
#3
Seung-Hoon Baek, Kang-Il Kim, Kyung-Sik Yoon, Tae-Ho Kim, Shin-Yoon Kim
Osteonecrosis of the femoral head (ONFH) is a multifactorial disease and is associated with genetic predisposition, and exposure to certain risk factors. In particular, idiopathic ONFH in twins and the clustering of cases in families have indicated that genetic factors are involved. However, the majority of cases of ONFH are sporadic and various studies have demonstrated that differences in the study design and/or the ethnic groups analyzed leads to different results. The present study performed one of the first genome‑wide association studies to identify genetic loci that may increase the risk of idiopathic ONFH...
December 14, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27994198/osteoprotegerin-polymorphisms-are-associated-with-alcohol-induced-osteonecrosis-of-femoral-head-in-chinese-han-population-from-henan-province
#4
Yizhou Li, Yongchang Guo, Quanjian Wang, Yongri Ouyang, Yuju Cao, Tianbo Jin, Jianzhong Wang
Alcohol-induced osteonecrosis of femoral head (ONFH) is one of the most important pathogenesis of nontraumatic ONFH. However, its pathogenesis mechanism is still unknown. Osteoprotegerin (OPG) has been implicated in multiple functions including blocking osteoclast maturation, controlling vascular calcifications, promoting tumour growth and metastasis. This study is focussed on OPG gene polymorphisms associated with alcohol-induced ONFH. A total of 509 participants (209 patients and 300 normal individuals) were recruited, and we selected 13 single-nucleotide polymorphisms (SNPs) to evaluate the association between genetic susceptibility variants and alcohol-induced ONFH by using the χ(2) test and genetic model analysis...
December 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27930516/single-nucleotide-polymorphisms-of-mmp2-in-mmp-timp-pathways-associated-with-the-risk-of-alcohol-induced-osteonecrosis-of-the-femoral-head-in-chinese-males-a-case-control-study
#5
Yan Yu, Zhilan Xie, Jihan Wang, Chu Chen, Shuli Du, Peng Chen, Bin Li, Tianbo Jin, Heping Zhao
The proportion of alcohol-induced osteonecrosis of the femoral head (ONFH) in all ONFH patients was 30.7%, with males prevailing among the ONFH patients in mainland China (70.1%). Matrix metalloproteinase 2 (MMP2), a member of the MMP gene family, encodes the enzyme MMP2, which can promote osteoclast migration, attachment, and bone matrix degradation. In this case-control study, we aimed to investigate the association between MMP2 and the alcohol-induced ONFH in Chinese males.In total, 299 patients with alcohol-induced ONFH and 396 healthy controls were recruited for a case-control association study...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27912962/the-influence-of-traditional-chinese-medicine-constitutions-on-the-potential-repair-capacity-after-osteonecrosis-of-the-femoral-head
#6
Tong Yu, Zhennan Zhang, Limin Xie, Xun Ke, Yang Liu
OBJECTIVES: To explore the effects of traditional Chinese medicine (TCM) constitutions on repair capacity after osteonecrosis of the femoral head (ONFH). DESIGN AND SETTING: Ninety-six patients with TCM constitutions of yang-deficiency, dampness-heat and/or blood-stasis were recruited from the orthopedic outpatient clinic of the Guang'anmen Hospital of the China Academy of Chinese Medical Science. Each patient underwent computed tomography (CT) examination of the hips, and CAD software was used to estimate proximal sclerosis ratios based on the CT images...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27910957/mir-27a-attenuates-adipogenesis-and-promotes-osteogenesis-in-steroid-induced-rat-bmscs-by-targeting-ppar%C3%AE-and-grem1
#7
Chenxi Gu, Yan Xu, Shanfeng Zhang, Hongya Guan, Shi Song, Xiuli Wang, Yisheng Wang, Yuebai Li, Guoqiang Zhao
The imbalance between adipogenic and osteogenic differentiation in bone marrow mesenchymal stem cells (BMSCs) plays a significant role in the pathogenesis of steroid-induced osteonecrosis of the femoral head (ONFH). Several microRNAs (miRNAs) are involved in regulating adipogenesis and osteogenesis. In this study, we established a steroid-induced ONFH rat model to identify the potential relevant miRNAs. We identified 9 up-regulated and 28 down-regulated miRNAs in the ONFH rat model. Of these, miR-27a was down-regulated and negatively correlated with peroxisome proliferator-activated receptor gamma (PPARγ) and gremlin 1 (GREM1) expression...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904218/core-decompression-or-quadratus-femoris-muscle-pedicle-bone-grafting-for-nontraumatic-osteonecrosis-of-the-femoral-head-a-randomized-control-study
#8
Deqiang Li, Ming Li, Peilai Liu, Yuankai Zhang, Liang Ma, Fei Xu
BACKGROUND: The traditional management for osteonecrosis of the femoral head (ONFH) includes core decompression (CD) and quadratus femoris muscle pedicle bone graft (QF-MPBG). The aim of this study was to investigate the effects of CD and QF-MPBG on the patients with nontraumatic ONFH in an early stage. MATERIALS AND METHODS: 39 patients (47 hips) with ONFH in an early stage (Ficat Stage I or II) were randomly divided into two groups according to random number table method...
November 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27888294/total-hip-arthroplasty-with-dual-mobility-cup-in-osteonecrosis-of-the-femoral-head-in-young-patients-over-ten-years-of-follow-up
#9
Pierre Martz, Alexandre Maczynski, Sebastien Elsair, Ludovic Labattut, Brice Viard, Emmanuel Baulot
Osteonecrosis of the femoral head affects mainly young patients with high functional needs this increases the risk of dislocation. Dual mobility cups known for low rate of dislocation and high mobility range seems indicated. We evaluate functional efficiency, survival and dislocation rate of dual mobility cup for total hip arthroplasty for osteonecrosis in young patients. Monocentric retrospective clinical study, from 2000 to 2008. With a clinical analysis in pre-operative and over ten years of follow-up of one cohort of patients under 55 years old with an indication of THA for ONFH...
November 25, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27882161/potential-diagnostic-role-of-diffusion-tensor-imaging-in-early-stage-osteonecrosis-of-the-femoral-head
#10
Hongwei Min, Feng Xu, Rui Gu, Xinzuo Han, Anqing Wang, Kemin Liu
The present study aimed to explore the potential diagnostic role of diffusion tensor magnetic resonance imaging (DTI) in the early stage of modified corticosteroid-induced osteonecrosis of the femoral head (ONFH). A total of 20 beagles were randomly classified (1:1) into either an experimental group (LM), which were intramuscularly injected with lipopolysaccharide (LPS) and methylprednisolone (MPS) on three consecutive days, or control (CON) group, which were injected with saline. Magnetic resonance imaging (MRI) and DTI were performed at pre-induction and 8 and 12 weeks post-induction...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882083/dimethyloxaloylglycine-increases-bone-repair-capacity-of-adipose-derived-stem-cells-in-the-treatment-of-osteonecrosis-of-the-femoral-head
#11
Zhen-Hong Zhu, Wen-Qi Song, Chang-Qing Zhang, Ji-Min Yin
Mesenchymal stem cells have been widely studied to promote local bone regeneration of osteonecrosis of the femoral head (ONFH). Previous studies observed that dimethyloxaloylglycine (DMOG) enhanced the angiogenic and osteogenic activity of mesenchymal stem cells by activating the expression of hypoxia inducible factor-1α (HIF-1α), thereby improving the bone repair capacity of mesenchymal stem cells. In the present study, it was investigated whether DMOG could increase the bone repair capacity of adipose-derived stem cells (ASCs) in the treatment of ONFH...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27858915/genetic-polymorphisms-of-cyp3a4-among-chinese-patients-with-steroid-induced-osteonecrosis-of-the-femoral-head
#12
Yuan Wang, Xiuling Li, Yaoyu Gao, Zhi Li, Lidong Yu, Qingbo Meng, Li Sun, Jianzhong Wang
BACKGROUND: Steroid therapy has been an important reason of nontraumatic osteonecrosis of the femoral head (ONFH). Steroids are metabolized by hepatic cytochrome P4503A, a low endogenous activity of this enzyme can contribute to the pathogenesis of ONFH. The aim of this study was to investigate the associations of polymorphisms of cytochrome P4503A4 (CYP3A4) gene with steroid-induced ONFH in Chinese patients. METHODS: A total of 150 steroid-induced ONFH patients and 250 healthy controls were enrolled...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27833839/patient-reported-outcomes-of-femoral-osteotomy-and-total-hip-arthroplasty-for-osteonecrosis-of-the-femoral-head-a-prospective-case-series-study
#13
Yusuke Kubo, Takuaki Yamamoto, Goro Motomura, Kazuyuki Karasuyama, Kazuhiko Sonoda, Yukihide Iwamoto
BACKGROUND: Patient-reported scoring systems have recently been used after surgical procedures. The purpose of this prospective study was to evaluate the patient-reported outcomes of femoral osteotomy and total hip arthroplasty (THA) for osteonecrosis of the femoral head (ONFH). METHODS: Forty-two symptomatic ONFH patients with asymptomatic contralateral hip underwent either transtrochanteric anterior rotational osteotomy (ARO) or THA as a primary operation. Of these, 20 patients whose contralateral hips remained asymptomatic at the final follow-up (more than 1 year postoperatively) were recruited to participate in this study...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27826791/rational-derivation-extension-and-cyclization-of-self-inhibitory-peptides-to-target-tgf-%C3%AE-bmp-signaling-in-onfh
#14
Zhenhong Zhu, Chi Zhang, Wenqi Song
The human transforming growth factor β (TGF-β)/bone morphogenic protein (BMP) signaling has been recognized as an attractive target to suppress fibroblast activation in osteonecrosis of the femoral head (ONFH). Here, we reported successful derivation of a self-inhibitory peptide from the crystal complex interface of TGF-β with its cognate receptor TβRI using rational molecular design and in vitro binding assay. Computational modeling suggested that the peptide possesses a large flexibility and would incur considerable entropy penalty...
November 9, 2016: Amino Acids
https://www.readbyqxmd.com/read/27779162/local-administration-of-bisphosphonate-soaked-hydroxyapatite-for-the-treatment-of-osteonecrosis-of-the-femoral-head-in-rabbit
#15
Jin-Hui Ma, Wan-Shou Guo, Zi-Rong Li, Bai-Liang Wang
BACKGROUND: Systemic administration of bisphosphonates has shown promising results in the treatment of osteonecrosis of the femoral head (ONFH). However, few studies have evaluated the efficacy of local zoledronate (ZOL) administration in the treatment of ONFH. The purpose of this study was to investigate whether local administration of bisphosphonate-soaked hydroxyapatite (HA) could improve bone healing in an experimental rabbit model of ONFH. METHODS: This experimental study was conducted between October 2014 and June 2015...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27766040/exosomes-from-human-synovial-derived-mesenchymal-stem-cells-prevent-glucocorticoid-induced-osteonecrosis-of-the-femoral-head-in-the-rat
#16
Shang-Chun Guo, Shi-Cong Tao, Wen-Jing Yin, Xin Qi, Jia-Gen Sheng, Chang-Qing Zhang
Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in the animal model of GC-induced ONFH by inducing cell proliferation and preventing cell apoptosis. Recent studies indicate the transplanted cells exert therapeutic effects primarily via a paracrine mechanism and exosomes are an important paracrine factor that can be directly used as therapeutic agents for tissue engineering...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27755641/radiologic-and-clinical-features-of-misdiagnosed-idiopathic-osteonecrosis-of-the-femoral-head
#17
Wataru Ando, Kengo Yamamoto, Tsuyoshi Koyama, Yoshichika Hashimoto, Takashi Tsujimoto, Kenji Ohzono
Idiopathic osteonecrosis of the femoral head (ONFH) can be correctly diagnosed in accordance with the established criteria. However, some general orthopedic physicians have misdiagnosed patients as having ONFH. The goal of this study was to clarify the radiologic and clinical features of misdiagnosed patients. This study included 50 patients who were referred to the authors' hospital by general physicians with a diagnosis of ONFH. The correct diagnosis was made based on the Japanese Investigation Committee diagnostic criteria for ONFH...
October 18, 2016: Orthopedics
https://www.readbyqxmd.com/read/27704894/associations-of-igfbp3-gene-polymorphism-and-gene-expression-with-the-risk-of-osteonecrosis-of-the-femoral-head-in-a-han-population-in-northern-china
#18
Yang Song, Zhenwu Du, Qiwei Yang, Ming Ren, Yujie Sui, Qingyu Wang, Ao Wang, Haiyue Zhao, Jincheng Wang, Guizhen Zhang
The critical roles of IGFBP3 in regulating the osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells strongly indicate its potential effects on the pathogenesis of osteonecrosis of the femoral head (ONFH). In this study, we investigated the association of IGFBP3 gene polymorphism and its protein expression with the development of ONFH to further explore its molecular pathogenesis. Ligase detection reactions and enzyme-linked immunosorbent assay were used to detect the polymorphisms of rs2453839[C/T] and rs3110697[A/G] and the serum protein expression of IGFBP3 gene in 182 cases and 179 controls, respectively...
December 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27703421/treatment-of-pre-collapse-stages-of-osteonecrosis-of-the-femoral-head-a-systematic-review-of-randomized-control-trials
#19
REVIEW
Jordan C Villa, Solomon Husain, Jelle P van der List, Arianna Gianakos, Joseph M Lane
BACKGROUND: Treatment for osteonecrosis of the femoral head (ONFH) remains controversial. Current reviews include low-level evidence studies evaluating the treatment of both pre-collapse and collapse stages of the disease. QUESTIONS/PURPOSES: The purpose of the current study is to systematically review the literature evaluating core decompression (CD) with bone marrow mesenchymal cells (BMMCs), CD alone, and bisphosphonate treatment in pre-collapse ONFH by focusing just on randomized clinical trials (RCTs) reporting functional and radiologic outcomes...
October 2016: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/27664561/dosage-effects-of-extracorporeal-shockwave-therapy-in-early-hip-necrosis
#20
Ching-Jen Wang, Chung-Cheng Huang, Hon-Kan Yip, Ya-Ju Yang
BACKGROUND: This study investigated the effects of different dosages of extracorporeal shockwave therapy (ESWT) in early osteonecrosis of the femoral head (ONFH). MATERIALS AND METHODS: Thirty-three patients (42 hips) were randomly divided into three groups. Group A (10 patients with 16 hips) received 2000 impulses of ESWT at 24 Kv to the affected hip. Group B (11 patients with 14 hips) and Group C (12 patients with 12 hips) received 4000 and 6000 impulses of ESWT respectively...
September 21, 2016: International Journal of Surgery
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