keyword
MENU ▼
Read by QxMD icon Read
search

Muscular spindle

keyword
https://www.readbyqxmd.com/read/29290914/endoscopic-ultrasound-guided-fine-needle-aspiration-for-diagnosing-a-rare-extraluminal-duodenal-gastrointestinal-tumor
#1
Kazunao Hayashi, Kenya Kamimura, Kazunori Hosaka, Satoshi Ikarashi, Junji Kohisa, Kazuya Takahashi, Kentaro Tominaga, Kenichi Mizuno, Satoru Hashimoto, Junji Yokoyama, Satoshi Yamagiwa, Kazuyasu Takizawa, Toshifumi Wakai, Hajime Umezu, Shuji Terai
Duodenal gastrointestinal stromal tumors (GISTs) are extremely rare disease entities, and the extraluminal type is difficult to diagnose. These tumors have been misdiagnosed as pancreatic tumors; hence, pancreaticoduodenectomy has been performed, although partial duodenectomy can be performed if accurately diagnosed. Developing a diagnostic methodology including endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA) has allowed us to diagnose the tumor directly through the duodenum. Here, we present a case of a 50-year-old woman with a 27-mm diameter tumor in the pancreatic uncus on computed tomography scan...
December 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29287185/insufficient-efficacy-of-vagus-nerve-stimulation-for-epileptic-spasms-and-tonic-spasms-in-children-with-refractory-epilepsy
#2
Tohru Okanishi, Ayataka Fujimoto, Mitsuyo Nishimura, Sotaro Kanai, Hirotaka Motoi, Yoichiro Homma, Hideo Enoki
BACKGROUND: Vagus nerve stimulation (VNS) leads to palliation of refractory seizures. Epileptic spasms (ES) and tonic spasms (TS) appear in children with West syndrome and symptomatic generalized epilepsy. Both types of spasms are often characterized by truncal muscular contractions and ictal electroencephalography (EEG) findings comprising the contiguous phases: phase 1) 15-20 Hz, spindle-like fast activity (occur in 70%), 2) diffuse polyphasic δ/θ waves (100%), and 3) electrodecremental activity (70%)...
December 15, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29222416/functional-analysis-of-human-intrafusal-fiber-innervation-by-human-%C3%AE-motoneurons
#3
A Colón, X Guo, N Akanda, Y Cai, J J Hickman
Investigation of neuromuscular deficits and diseases such as SMA, as well as for next generation prosthetics, utilizing in vitro phenotypic models would benefit from the development of a functional neuromuscular reflex arc. The neuromuscular reflex arc is the system that integrates the proprioceptive information for muscle length and activity (sensory afferent), to modify motoneuron output to achieve graded muscle contraction (actuation efferent). The sensory portion of the arc is composed of proprioceptive sensory neurons and the muscle spindle, which is embedded in the muscle tissue and composed of intrafusal fibers...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29192166/spindle-associated-membrane-protein-1-samp1-is-required-for-the-differentiation-of-muscle-cells
#4
Mohammed Hakim Jafferali, Ricardo A Figueroa, Mehedi Hasan, Einar Hallberg
Muscles are developed and regenerated in a differentiation process called myogenesis, which involves components of the nuclear envelope. We have investigated Samp1 (Spindle Associated Membrane Protein 1), a transmembrane nuclear envelope protein, which interacts with emerin and lamin A, both of which are linked to Emery-Dreifuss muscular dystrophy (EDMD). We found that the levels of Samp1 increased seven-fold during differentiation of mouse C2C12 muscle progenitor cells. To test if Samp1 could have a role in myogenesis we developed stable C2C12 knockdown cell lines expressing short hairpin RNA targeting Samp1 expression...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158164/lmo7-exerts-an-effect-on-mitosis-progression-and-the-spindle-assembly-checkpoint
#5
Yao-Wei Tzeng, Dai-Yu Li, Yvan Chen, Cheng-Hsiu Yang, Chih-Yun Chang, Yue-Li Juang
LMO7 (LIM domain only 7) is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy-relevant genes, and binds to α-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. In this study, we found that human LMO7 interacted with the spindle assembly checkpoint (SAC) protein MAD1. LMO7 colocalized with actin filaments at the cell membrane but did not colocalize with MAD1 at kinetochores in prometaphase. Our observations reveal that overexpression but not depletion of LMO7 caused a SAC defect, and that the LIM domain of LMO7 was a determinant of its ability to interfere with kinetochore localization of the SAC proteins MAD2 and BUBR1 and cause a SAC defect though the LIM peptide itself did neither bind to MAD1, MAD2 and BUBR1 nor localize to the actin filaments...
November 17, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29046797/gastrointestinal-tract-like-muscular-walls-in-ovarian-mature-cystic-teratomas-a-histopathological-study
#6
Susumu Matsukuma, Oh Takahashi, Yoshitaka Utsumi, Kosuke Miyai, Hiroaki Takeo
To elucidate the frequency and histopathological features of gastrointestinal (GI) tract-like muscular walls developing in ovarian mature cystic teratoma (MCT), the present study examined 149 MCTs surgically removed from 126 females, including 23 bilateral cases. GI tract-like muscular walls were identified in 9 (7.1%) cases, and were accompanied by mucosa in 5 cases, muscularis mucosae in 5 cases, serosa in 5 cases and all of these components in 3 cases. The mean size of the GI tract-like structures was 0...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28856628/primary-colonic-well-differentiated%C3%A2-%C3%A2-dedifferentiated-liposarcoma-of-the-ascending-colon-a-case-report
#7
Hiroshi Sawayama, Naoya Yoshida, Yuji Miyamoto, Tomoyuki Uchihara, Tasuku Toihata, Taisuke Yagi, Yukiharu Hiyoshi, Masaaki Iwatsuki, Yoshifumi Baba, Hideo Baba
BACKGROUND: Primary colonic and dedifferentiated liposarcomas are both remarkably rare. This work describes a case of primary colonic well-differentiated/dedifferentiated liposarcoma and reviews the clinical characteristics and current therapies for liposarcoma tumors. CASE PRESENTATION: A 52-year-old woman was referred to our hospital with a submucosal tumor of the ascending colon. Clinical analysis by ultrasound colonoscopy and computed tomography revealed a partially ossified tumor with irregular edges continuous with the muscular layer...
August 30, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28823036/muscular-responses-appear-to-be-associated-with-existence-of-kinesthetic-perception-during-combination-of-tendon-co-vibration-and-motor-imagery
#8
Eriko Shibata, Fuminari Kaneko, Masaki Katayose
The afferent inputs from peripheral sensory receptors and efferent signals from the central nervous system that underlie intentional movement can contribute to kinesthetic perception. Previous studies have revealed that tendon vibration to wrist muscles elicits an excitatory response-known as the antagonist vibratory response-in muscles antagonistic to the vibrated muscles. Therefore, the present study aimed to further investigate the effect of tendon vibration combined with motor imagery on kinesthetic perception and muscular activation...
November 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28542067/grb2-associated-binder-1-is-required-for-extrafusal-and-intrafusal-muscle-fiber-development
#9
So Y Park, So Y Jang, Yoon K Shin, Byeol A Yoon, Hye J Lee, Hwan T Park
The neuregulin-1 (NRG1) signaling pathway plays an important role in the development of the peripheral neuromuscular system, including in muscle spindle and postnatal myelination. We previously showed that NRG1 on the axonal membrane regulates peripheral nerve myelination through Grb2-associated binder 1 (Gab1), a scaffolding mediator of receptor tyrosine kinase signaling. Here, we determined the role of Gab1 in the development of muscles and the muscle spindle using muscle-specific conditional Gab1 knockout mice...
July 5, 2017: Neuroreport
https://www.readbyqxmd.com/read/28457998/whole-body-vibration-induces-distinct-reflex-patterns-in-human-soleus-muscle
#10
Ilhan Karacan, Muharrem Cidem, Mehmet Cidem, Kemal S Türker
The neuronal mechanisms underlying whole body vibration (WBV)-induced muscular reflex (WBV-IMR) are not well understood. To define a possible pathway for WBV-IMR, this study investigated the effects of WBV amplitude on WBV-IMR latency by surface electromyography analysis of the soleus muscle in human adult volunteers. The tendon (T) reflex was also induced to evaluate the level of presynaptic Ia inhibition during WBV. WBV-IMR latency was shorter when induced by low- as compared to medium- or high-amplitude WBV (33...
June 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28317591/renal-myolipoosteoma-a-distinctive-lesion-in-a-child
#11
REVIEW
Hongbiao Jing, Tailing Li, Shujian Zhai, Yan Xi, Qingda Meng
We describe a distinctive renal tumor, a myolipoosteoma (MLO), in an 11-year-old boy who presented with a 6-month history of slight right flank intermittent pain. A gross examination revealed a well-defined, 5.5 cm mass with bone-like consistency. The lesion histologically featured an admixture of mature adipose tissue, spindle cells, and bony components. No atypia, mitotic activity, or pleomorphisms were observed in the tumor. The spindle cells were smooth muscle actin (SMA) and desmin positive but HMB45 and Melan-A negative, indicating that they were of a muscular nature and differed from that of angiomyolipoma (AML)...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28224240/simulation-of-cell-substrate-traction-force-dynamics-in-response-to-soluble-factors
#12
Tao Liu
Finite element (FE) simulations of contractile responses of vascular muscular thin films (vMTFs) and endothelial cells resting on an array of microposts under stimulation of soluble factors were conducted in comparison with experimental measurements reported in the literature. Two types of constitutive models were employed in the simulations, i.e. smooth muscle cell type and non-smooth muscle cell type. The time histories of the effects of soluble factors were obtained via calibration against experimental measurements of contractile responses of tissues or cells...
August 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28159911/nerve-specific-input-modulation-to-spinal-neurons-during-a-motor-task-in-the-monkey
#13
Joachim Confais, Geehee Kim, Saeka Tomatsu, Tomohiko Takei, Kazuhiko Seki
If not properly regulated, the large amount of reafferent sensory signals generated by our own movement could destabilize the CNS. We investigated how input from peripheral nerves to spinal cord is modulated during behavior. We chronically stimulated the deep radial nerve (DR; proprioceptive, wrist extensors), the median nerve (M; mixed, wrist flexors and palmar skin) and the superficial radial nerve (SR; cutaneous, hand dorsum) while four monkeys performed a delayed wrist flexion-extension task. Spinal neurons putatively receiving direct sensory input were defined based on their evoked response latency following nerve stimulation...
March 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27666369/tbce-mutations-cause-early-onset-progressive-encephalopathy-with-distal-spinal-muscular-atrophy
#14
Antonella Sferra, Gilbert Baillat, Teresa Rizza, Sabina Barresi, Elisabetta Flex, Giorgio Tasca, Adele D'Amico, Emanuele Bellacchio, Andrea Ciolfi, Viviana Caputo, Serena Cecchetti, Annalaura Torella, Ginevra Zanni, Daria Diodato, Emanuela Piermarini, Marcello Niceta, Antonietta Coppola, Enrico Tedeschi, Diego Martinelli, Carlo Dionisi-Vici, Vincenzo Nigro, Bruno Dallapiccola, Claudia Compagnucci, Marco Tartaglia, Georg Haase, Enrico Bertini
Tubulinopathies constitute a family of neurodevelopmental/neurodegenerative disorders caused by mutations in several genes encoding tubulin isoforms. Loss-of-function mutations in TBCE, encoding one of the five tubulin-specific chaperones involved in tubulin folding and polymerization, cause two rare neurodevelopmental syndromes, hypoparathyroidism-retardation-dysmorphism and Kenny-Caffey syndrome. Although a missense mutation in Tbce has been associated with progressive distal motor neuronopathy in the pmn/pmn mice, no similar degenerative phenotype has been recognized in humans...
October 6, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27590447/cellular-evidence-of-telocytes-as-novel-interstitial-cells-within-the-magnum-of-chicken-oviduct
#15
Ping Yang, Xudong Zhu, Lingling Wang, Nisar Ahmed, Yufei Huang, Hong Chen, Qian Zhang, Shakeeb Ullah, Tengfei Liu, Dawei Guo, Sarfaraz Ahmed Brohi, Qiusheng Chen
Telocytes are a novel type of interstitial cell that has been identified in many organs of mammals, but there is little information available on these cells in avian species. This study shows the latest findings associated with telocytes in the muscular layer and lamina propria of the magnum of chicken oviduct analyzed by transmission electron microscopy. Telocytes are characterized by telopodes, which are thin and long prolongations, and a small amount of cytoplasm rich with mitochondria. Spindle- or triangular-shaped telocytes were detected at various locations in the magnum...
January 24, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/27560658/immunomodulatory-capacity-of-the-local-mesenchymal-stem-cells-transplantation-after-severe-skeletal-muscle-injury-in-female-rats
#16
Mona A M Helal, Noura E M Shaheen, Fatma A Abu Zahra
CONTEXT: Cell therapy technique with stem cells is a very attractive strategy for the treatment of muscle disorders. OBJECTIVE: The objective of this study was to investigate the mechanism of local transplantation of mesenchymal stem cells (MSCs) which could contribute to skeletal muscle healing. MATERIALS AND METHODS: Female rats were divided into three equal groups as the following: group 1, the negative control group (untreated group), group 2, sham-treated group, rats with muscle injuries involving volumetric muscle loss (VML) of adductor brevis muscle and injected locally with phosphate-buffered saline (PBS) 0...
August 25, 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27068506/angioleiomyoma-in-a-conger-conger-conger
#17
F Marino, L Licata, M Albano, A Ieni, G Di Caro, B Macrì
A wild adult male conger Conger conger, captured by a SCUBA diver in the waters of coastal Italy, was sent for laboratory analysis due to the presence of multiple productive ulcerous skin lesions localized in the dorso-lateral body area, caudally to the gill operculum under the dorsal fin. The main mass was sessile, ulcerated and hemorrhaging in appearance and was surrounded by several smaller masses, which originated peripherally from the same mass or were isolated, always with a tendency to ulceration. Histology confirmed that the newly formed tissue originated from derma invading the closer tissues...
April 12, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/26793900/extreme-spindles-and-leukoencephalopathy-after-acute-lymphoblastic-leukemia-treatment-an-undescribed-association
#18
Paulo Afonso Medeiros Kanda, Rafael Guimarães Kanda, Paulo Afonso Mei, Ivan José Cury
We report a case of a child whose EEG demonstrated extreme spindles (ES) after acute lymphoblastic leukemia treatment. This finding has not been reported previously. In 1962, Gibbs and Gibbs described the ES EEG pattern due to its high amplitude (200 to 400 μV). ES are a rare spindle variant that is found in EEGs of 0.05% of normal children (average age, 3 years, with a range of 1 to 12 years), and are even rarer after 11 years. Moreover due to changes in the white matter of the frontal lobe, ES have been associated with such conditions as cerebral palsy and mental retardation, residual brain damage, undefined infections, infantile neuroaxonal dystrophy, Menkes' kinky-hair syndrome, congenital muscular dystrophy, hydrocephalus, porencephaly, epilepsy, progressive cerebellar degeneration, and mycoplasma encephalitis...
December 2015: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/26691377/ultrastructure-and-histogenesis-of-the-acral-calcified-angioleiomyoma
#19
Lucio Díaz-Flores, Ricardo Gutiérrez, Hugo Alvarez-Argüelles, Miriam González-Gómez, Maria Del Pino García, Lucio Díaz-Flores
We studied the ultrastructure, immunohistochemistry, and histogenesis of the acral calcified angioleiomyoma, observing three concentric zones: (a) pseudocapsular, thin, with spindle-shaped stromal cells (SCs), presenting scarce organelles and expressing CD34, (b) muscular, forming a ring, with smooth muscle cells of heterogenous phenotype (mainly in quantity and thickness of filaments, and in expression of h-caldesmon, αSMA, and desmin), and (c) central, extensive, calcified (spicular and/or star-shaped calcium deposits around collagen fibers), with pericytic involutive vasculature...
2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/26601735/an-update-on-primary-hepatic-solitary-fibrous-tumor-an-examination-of-the-clinical-and-pathological-features-of-four-case-studies-and-a-literature-review
#20
REVIEW
Long-Hai Feng, Hui Dong, Yu-Yao Zhu, Wen-Ming Cong
BACKGROUND: Primary hepatic solitary fibrous tumor is a rare neoplasm that originates in the submesothelial tissue of the liver and is frequently misdiagnosed because of its rarity and unfamiliar characteristics. AIM: To analyze, summarize and update the clinical and pathological features of primary hepatic solitary fibrous tumor. METHODS: We systematically extract the clinical data of 4 cases from the relevant medical records, analyze the macroscopic, histological and immunohistochemical features and review the 59 previously reported cases in the English literatures...
December 2015: Pathology, Research and Practice
keyword
keyword
33410
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"