keyword
https://read.qxmd.com/read/37628964/probing-the-effect-of-acidosis-on-tether-mode-mechanotransduction-of-proprioceptors
#21
JOURNAL ARTICLE
Yuan-Ren Cheng, Chih-Hung Chi, Cheng-Han Lee, Shing-Hong Lin, Ming-Yuan Min, Chih-Cheng Chen
Proprioceptors are low-threshold mechanoreceptors involved in perceiving body position and strain bearing. However, the physiological response of proprioceptors to fatigue- and muscle-acidosis-related disturbances remains unknown. Here, we employed whole-cell patch-clamp recordings to probe the effect of mild acidosis on the mechanosensitivity of the proprioceptive neurons of dorsal root ganglia (DRG) in mice. We cultured neurite-bearing parvalbumin-positive (Pv+) DRG neurons on a laminin-coated elastic substrate and examined mechanically activated currents induced through substrate deformation-driven neurite stretch (SDNS)...
August 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37628441/biological-responses-to-local-vibratory-stimulation-for-the-lower-legs-and-lower-back-and-criterion-values-based-on-sweep-frequencies-of-healthy-individuals-an-observational-study
#22
JOURNAL ARTICLE
Keitaro Kawai, Yoshiji Kato, Tadashi Ito, Kazunori Yamazaki, Jo Fukuhara, Yoshihito Sakai, Yoshifumi Morita
Declining proprioceptive function is associated with problems such as lower back pain and falls. Therefore, we developed a vibration device using sweep frequency to evaluate several proprioceptors with different response frequency ranges. This study aimed to elucidate the biological responses of healthy individuals to vibratory stimulation at different sites and frequency ranges and to propose cutoff values to determine the decline in proprioceptive function. Mechanical vibration was separately applied to the lower legs and lower back, and proprioceptive function was evaluated by defining the ratio of the center of pressure (CoP) in the anteroposterior direction during mechanical vibration to that during no vibration in the three frequency ranges...
August 9, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37564629/distinctive-features-of-the-central-synaptic-organization-of-drosophila-larval-proprioceptors
#23
JOURNAL ARTICLE
Marie R Greaney, Chris C Wreden, Ellie S Heckscher
Proprioceptive feedback is critically needed for locomotor control, but how this information is incorporated into central proprioceptive processing circuits remains poorly understood. Circuit organization emerges from the spatial distribution of synaptic connections between neurons. This distribution is difficult to discern in model systems where only a few cells can be probed simultaneously. Therefore, we turned to a relatively simple and accessible nervous system to ask: how are proprioceptors' input and output synapses organized in space, and what principles underlie this organization? Using the Drosophila larval connectome, we generated a map of the input and output synapses of 34 proprioceptors in several adjacent body segments (5-6 left-right pairs per segment)...
2023: Frontiers in Neural Circuits
https://read.qxmd.com/read/37562405/biomechanical-origins-of-proprioceptor-feature-selectivity-and-topographic-maps-in-the-drosophila-leg
#24
JOURNAL ARTICLE
Akira Mamiya, Anne Sustar, Igor Siwanowicz, Yanyan Qi, Tzu-Chiao Lu, Pralaksha Gurung, Chenghao Chen, Jasper S Phelps, Aaron T Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Hongjie Li, Natasha Mhatre, John C Tuthill
Our ability to sense and move our bodies relies on proprioceptors, sensory neurons that detect mechanical forces within the body. Different subtypes of proprioceptors detect different kinematic features, such as joint position, movement, and vibration, but the mechanisms that underlie proprioceptor feature selectivity remain poorly understood. Using single-nucleus RNA sequencing (RNA-seq), we found that proprioceptor subtypes in the Drosophila leg lack differential expression of mechanosensitive ion channels...
August 4, 2023: Neuron
https://read.qxmd.com/read/37457034/edge-computing-in-nature-minimal-pre-processing-of-multi-muscle-ensembles-of-spindle-signals-improves-discriminability-of-limb-movements
#25
JOURNAL ARTICLE
Jasmine A Berry, Ali Marjaninejad, Francisco J Valero-Cuevas
Multiple proprioceptive signals, like those from muscle spindles, are thought to enable robust estimates of body configuration. Yet, it remains unknown whether spindle signals suffice to discriminate limb movements. Here, a simulated 4-musculotendon, 2-joint planar limb model produced repeated cycles of five end-point trajectories in forward and reverse directions, which generated spindle Ia and II afferent signals (proprioceptors for velocity and length, respectively) from each musculotendon. We find that cross-correlation of the 8D time series of raw firing rates (four Ia, four II) cannot discriminate among most movement pairs (∼ 29% accuracy)...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37427821/-problems-and-prospects-of-kinesiotaping-use-in-clinical-practice
#26
JOURNAL ARTICLE
M A Spirina, T I Vlasova, A V Sitdikova, E A Shamrova
Currently the concept of kinesiotaping has become widespread. Kinesiotaping, which was originally implemented in sports medicine, is increasingly used in rehabilitation and various spheres of medicine, such as orthopedics, traumatology, pediatrics, etc. In recent years, the new publications about the kinesiotaping use in neurology and rheumatology have been released, where previously unknown effects, such as improved sensory feedback, have been demonstrated. Great attention is paid to comparative studies of the effects of kinesiotaping and other methods of taping, which have been used for many years...
2023: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://read.qxmd.com/read/37417654/role-of-proprioceptors-in-chronic-musculoskeletal-pain
#27
REVIEW
Cheng-Han Lee, Chih-Cheng Chen
NEW FINDINGS: What is the topic of this review? Why proprioceptors, which are non-nociceptive, low-threshold mechanosensory neurons that monitor muscle contraction and body position, express several proton-sensing ion channels and receptors. What advances does it highlight? ASIC3 is a dual function protein for proton-sensing and mechano-sensing in proprioceptors that can be activated by eccentric muscle contraction or lactic acidosis. A role is proposed for proprioceptors in non-nociceptive unpleasantness (or sng), which is associated with their acid-sensing properties, in chronic musculoskeletal pain...
July 7, 2023: Experimental Physiology
https://read.qxmd.com/read/37326668/biomechanical-and-cortical-control-of-tongue-movements-during-chewing-and-swallowing
#28
REVIEW
Callum F Ross, J D Laurence-Chasen, Peishu Li, Courtney Orsbon, Nicholas G Hatsopoulos
Tongue function is vital for chewing and swallowing and lingual dysfunction is often associated with dysphagia. Better treatment of dysphagia depends on a better understanding of hyolingual morphology, biomechanics, and neural control in humans and animal models. Recent research has revealed significant variation among animal models in morphology of the hyoid chain and suprahyoid muscles which may be associated with variation in swallowing mechanisms. The recent deployment of XROMM (X-ray Reconstruction of Moving Morphology) to quantify 3D hyolingual kinematics has revealed new details on flexion and roll of the tongue during chewing in animal models, movements similar to those used by humans...
June 16, 2023: Dysphagia
https://read.qxmd.com/read/37279454/mechanistic-hypotheses-for-proprioceptive-sensing-within-the-avian-lumbosacral-spinal-cord
#29
JOURNAL ARTICLE
Kathryn E Stanchak, Kimberly E Miller, Devany Shikiar, Bingni W Brunton, David J Perkel
Animals need to accurately sense changes in their body position to perform complex movements. It is increasingly clear that the vertebrate central nervous system contains a variety of cells capable of detecting body motion, in addition to the comparatively well-understood mechanosensory cells of the vestibular system and the peripheral proprioceptors. One such intriguing system is the lower spinal cord and column in birds, also known as the avian lumbosacral organ (LSO), which is thought to act as a set of balance sensors that allow birds to detect body movements separately from head movements detected by the vestibular system...
June 2, 2023: Integrative and Comparative Biology
https://read.qxmd.com/read/37214153/does-surgical-resection-of-horizontal-extraocular-muscles-disrupt-ocular-proprioceptors
#30
JOURNAL ARTICLE
Ala Paduca, Per O Lundmark, J Richard Bruenech
PURPOSE: It has been promoted that disturbance of ocular proprioception may play a role in the pathogenesis of concomitant strabismus and other types of oculomotor anomalies. The aim of the study was to obtain knowledge about how surgical foreshortening of the myotendinous region potentially affects the proprioceptors that resides in this area of the muscles and to test the hypothesis that avoiding disruption of ocular proprioceptors result in a more favorable long term postoperative result...
2023: Clinical Ophthalmology
https://read.qxmd.com/read/37206924/isolation-of-human-pluripotent-stem-cell-derived-sensory-neuron-subtypes-by-immunopanning
#31
JOURNAL ARTICLE
Kenyi Saito-Diaz, Christina James, Archie Jayesh Patel, Nadja Zeltner
Sensory neurons (SNs) detect a wide range of information from the body and the environment that is critical for homeostasis. There are three main subtypes of SNs: nociceptors, mechanoreceptors, and proprioceptors, which express different membrane proteins, such as TRKA, TRKB, or TRKC, respectively. Human pluripotent stem cell technology provides an ideal platform to study development and diseases of SNs, however there is not a viable method to isolate individual SN subtype for downstream analysis available...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37119460/mechanosensory-encoding-in-ex-vivo-muscle-nerve-preparations
#32
REVIEW
Stephen N Housley, Evelyn A Gardolinski, Paul Nardelli, J'Ana Reed, Mark M Rich, Timothy C Cope
NEW FINDINGS: What is the central question of this study? How well have studies using ex vivo  muscle- nerve preparations represented in vivo features of sensory encoding by low threshold mechanoreceptors in muscle? What is the main finding and its importance? We find experimental adjustments to the ex vivo approach that improve representation of mechanosensory encoding observed in vivo. These adjustments will enhance accuracy in the search for molecular identity and encoding mechanisms of heterogeneous muscle mechanosensory neurons...
April 29, 2023: Experimental Physiology
https://read.qxmd.com/read/37040389/enhanced-corticospinal-excitability-in-the-tibialis-anterior-during-static-stretching-of-the-soleus-in-young-healthy-individuals
#33
JOURNAL ARTICLE
Francesco Budini, Monica Christova
Corticospinal excitability is known to be affected by afferent inflow arising from the proprioceptors during active or passive muscle movements. Also during static stretching (SS) afferent activity is enhanced, but its effect on corticospinal excitability received limited attention and has only been investigated as a single average value spread over the entire stretching period. Using transcranial magnetic stimulation (TMS) the present study was conducted to explore the time course of corticospinal excitability during 30 seconds SS...
2023: PloS One
https://read.qxmd.com/read/36991912/effects-of-sensing-tactile-arrays-shear-force-and-proprioception-of-robot-on-texture-recognition
#34
JOURNAL ARTICLE
Jung-Hwan Yang, Seong-Yong Kim, Soo-Chul Lim
In robotics, tactile perception is important for fine control using robot grippers and hands. To effectively incorporate tactile perception in robots, it is essential to understand how humans use mechanoreceptors and proprioceptors to perceive texture. Thus, our study aimed to investigate the impact of tactile sensor arrays, shear force, and the positional information of the robot's end effector on its ability to recognize texture. A deep learning network was employed to classify tactile data from 24 different textures that were explored by a robot...
March 17, 2023: Sensors
https://read.qxmd.com/read/36923003/symbiotic-electroneural-and-musculoskeletal-framework-to-encode-proprioception-via-neurostimulation-propriostim
#35
JOURNAL ARTICLE
Andrea Cimolato, Federico Ciotti, Jelena Kljajić, Giacomo Valle, Stanisa Raspopovic
Peripheral nerve stimulation in amputees achieved the restoration of touch, but not proprioception, which is critical in locomotion. A plausible reason is the lack of means to artificially replicate the complex activity of proprioceptors. To uncover this, we coupled neuromuscular models from ten subjects and nerve histologies from two implanted amputees to develop ProprioStim: a framework to encode proprioception by electrical evoking neural activity in close agreement with natural proprioceptive activity. We demonstrated its feasibility through non-invasive stimulation on seven healthy subjects comparing it with standard linear charge encoding...
March 17, 2023: IScience
https://read.qxmd.com/read/36908788/plastic-changes-induced-by-muscle-focal-vibration-a-possible-mechanism-for-long-term-motor-improvements
#36
JOURNAL ARTICLE
Guido M Filippi, Angelo Rodio, Luigi Fattorini, Mario Faralli, Giampietro Ricci, Vito E Pettorossi
Repetitive focal vibrations can induce positive and persistent after-effects. There is still no satisfactory interpretation of the underlying mechanisms. A rationale, which can provide consistency among different results, is highly desirable to guide both the use of the application and future research. To date, interpretive models are formulated to justify the results, depending on the specific protocol adopted. Indeed, protocol parameters, such as stimulus intensity and frequency, intervention time and administration period, are variable among different studies...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/36869596/proprioceptors-in-extraocular-muscles
#37
REVIEW
Roland Blumer, Génova Carrero-Rojas, Paula M Calvo, Johannes Streicher, Rosa R de la Cruz, Angel M Pastor
NEW FINDINGS: What is the topic of this review? This review aims to evaluate the literature on proprioceptors and particular nerve specializations (palisade endings) in mammalian extraocular muscles (EOMs) and to reconsider current knowledge of their structure and function. What advances does it highlight? Classical proprioceptors (muscle spindles and Golgi tendon organs) are absent in the EOMs of most mammals. Instead, palisade endings are present in most mammalian EOMs. For many years, palisade endings were considered to be sensory but recent studies show that they combine sensory and motor features...
March 3, 2023: Experimental Physiology
https://read.qxmd.com/read/36865673/proprioceptors-enriched-neuronal-cultures-from-induced-pluripotent-stem-cells-from-friedreich-ataxia-patients-show-altered-transcriptomic-and-proteomic-profiles-abnormal-neurite-extension-and-impaired-electrophysiological-properties
#38
JOURNAL ARTICLE
Chiara Dionisi, Marine Chazalon, Myriam Rai, Céline Keime, Virginie Imbault, David Communi, Hélène Puccio, Serge N Schiffmann, Massimo Pandolfo
Friedreich ataxia is an autosomal recessive multisystem disorder with prominent neurological manifestations and cardiac involvement. The disease is caused by large GAA expansions in the first intron of the FXN gene, encoding the mitochondrial protein frataxin, resulting in downregulation of gene expression and reduced synthesis of frataxin. The selective loss of proprioceptive neurons is a hallmark of Friedreich ataxia, but the cause of the specific vulnerability of these cells is still unknown. We herein perform an in vitro characterization of human induced pluripotent stem cell-derived sensory neuronal cultures highly enriched for primary proprioceptive neurons...
2023: Brain communications
https://read.qxmd.com/read/36842298/adapting-the-pantograph-limb-differential-robustness-of-fore-and-hindlimb-kinematics-against-genetically-induced-perturbation-in-the-neural-control-networks-and-its-evolutionary-implications
#39
JOURNAL ARTICLE
Danny Schnerwitzki, Christoph Englert, Manuela Schmidt
The evolutionary transformation of limb morphology to the four-segmented pantograph of therians is among the milestones of mammalian evolution. But, it is still unknown if changes of the mechanical limb function were accompanied by corresponding changes in development and sensorimotor control. The impressive locomotor performance of mammals leaves no doubt about the high integration of pattern formation, neural control and mechanics. But, deviations from normal intra- and interlimb coordination (spatial and temporal) become evident in the presence of perturbations...
April 2023: Zoology: Analysis of Complex Systems, ZACS
https://read.qxmd.com/read/36791896/proprioceptive-response-strength-in-the-primary-sensorimotor-cortex-is-invariant-to-the-range-of-finger-movement
#40
JOURNAL ARTICLE
Timo Nurmi, Maria Hakonen, Mathieu Bourguignon, Harri Piitulainen
Proprioception is the sense of body position and movement that relies on afference from the proprioceptors in muscles and joints. Proprioceptive responses in the primary sensorimotor (SM1) cortex can be elicited by stimulating the proprioceptors using evoked (passive) limb movements. In magnetoencephalography (MEG), proprioceptive processing can be quantified by recording the movement evoked fields (MEFs) and movement-induced beta power modulations or by computing corticokinematic coherence (CKC) between the limb kinematics and cortical activity...
February 13, 2023: NeuroImage
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