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https://www.readbyqxmd.com/read/29679732/inter-site-variability-of-the-osteocyte-lacunar-network-in-the-cortical-bone-underpins-fracture-susceptibility-of-the-superolateral-femoral-neck
#1
Tim Rolvien, Annika Vom Scheidt, Kilian Stockhausen, Petar Milovanovic, Danijela Djonic, Jan Hubert, Thelonius Hawellek, Alexander Wacker, Volker Jebens, Klaus Püschel, Elizabeth A Zimmermann, Marija Djuric, Michael Amling, Björn Busse
BACKGROUND: The osteocytic lacunar network is considered to be an integral player in the regulation of bone homeostasis, and reduction in osteocytes is associated with reduced bone strength. Here, we analyzed site-specific patterns in osteocyte characteristics and matrix composition in the cortical compartment of the femoral neck to reveal structural basis of its fragility. METHODS: Cross-sections of the human femoral neck - one of the most common fracture sites - were acquired from 12 female cadavers (age 34-86 years) and analyzed with backscattered scanning electron microscopy and high-resolution micro-computed tomography (μ-CT)...
April 18, 2018: Bone
https://www.readbyqxmd.com/read/29679551/histological-and-mechanical-evaluation-of-antifreeze-peptide-afp1m-cryopreserved-skin-grafts-post-transplantation-in-a-rat-model
#2
S M Ibrahim, O H Kareem, K M Saffanah, A A Adamu, M S Khan, M B A Rahman, M M Noordin, M Y Loqman
The objective of this study was to evaluate the use of Afp1m as a cryopreservative agent for skin by examining the transplanted skin histological architecture and mechanical properties following subzero cryopreservation. Thirty four (34) rats with an average weight of 208 ± 31 g (mean ± SD), were used. Twenty four (n = 24) rats were equally divided into four groups: (i) immediate non-cryopreserved skin autografts (onto same site), (ii) immediate non-cryopreserved skin autografts (onto different sites), (iii) skin autografts cryopreserved with glycerol for 72 h and (iv) skin autografts cryopreserved with Afp1m for 72 h at -4 °C...
April 18, 2018: Cryobiology
https://www.readbyqxmd.com/read/29679498/7t-ultra-high-field-body-mr-imaging-with-an-8-channel-transmit-32-channel-receive-radiofrequency-coil-array
#3
Stefan H G Rietsch, Stephan Orzada, Stefan Maderwald, Sascha Brunheim, Bart W J Philips, Tom W J Scheenen, Mark E Ladd, Harald H Quick
PURPOSE: In this work a combined body coil array with 8 transmit/receive (Tx/Rx) meander elements and with 24 receive-only (Rx) loops (8Tx/32Rx) was developed and evaluated in comparison to an 8-channel transmit/receive body array (8Tx/Rx) based on meander elements serving as the reference standard. METHODS: Systematic evaluation of the RF array was performed on a body-sized phantom. Body imaging at 7T was performed in 6 volunteers in the body regions pelvis, abdomen, and heart...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29679270/mutagenic-assessment-of-lithobates-catesbeianus-tadpoles-exposed-to-the-2-4-d-herbicide-in-a-simulated-realistic-scenario
#4
Carlos Mesak, Bruna de Oliveira Mendes, Raíssa de Oliveira Ferreira, Guilherme Malafaia
The aim of the current study is to assess possible erythrocyte mutagenic effects on Lithobates catesbeianus tadpoles exposed to water contaminated with 2,4-D. In order to do so, tadpoles were exposed to a predictive and environmentally relevant herbicide concentration (1.97 mg/L), which is likely to be found in lentic environments formed by superficial water runoffs in pasture areas where the herbicide was applied. The micronucleus test, as well as tests for other nuclear abnormalities, was conducted after 3, 5, and 9 days of exposure (d...
April 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29678902/development-of-a-breast-cancer-risk-prediction-model-for-women-in-nigeria
#5
Shengfeng Wang, Temidayo O Ogundiran, Adeyinka Ademola, Olayiwola A Oluwasola, Adewunmi O Adeoye, Adenike Sofoluwe, Imran Morhason-Bello, Stella O Odedina, Imaria Agwai, Clement Adebamowo, Millicent Obajimi, Oladosu Ojengbede, Olufunmilayo I Olopade, Dezheng Huo
BACKGROUND: Risk prediction models have been widely used to identify women at higher risk of breast cancer. We aim to develop a model for absolute breast cancer risk prediction for Nigerian women. METHODS: A total of 1,811 breast cancer cases and 2,225 controls from the Nigerian Breast Cancer Study (NBCS, 1998~2015) were included. Subjects were randomly divided into the training and validation sets. Incorporating local incidence rates, multivariable logistic regressions were used to develop the model...
April 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29678488/medicolegal-considerations-involving-iatrogenic-lingual-nerve-damage
#6
REVIEW
Roberto Pippi, Andrea Spota, Marcello Santoro
The aim of this review is to improve risk management strategies through analysis of the anatomic, semeiotic, and medicolegal aspects that characterize iatrogenic lingual nerve damage (LND) and its legal consequences in the case of legal proceedings for a claim for compensation. In dental practice, LND can be caused by local or general anesthesia or by mechanical, chemical, or thermal mechanisms. A certain postoperative identification of LND etiopathogenesis is often very challenging because it can be difficult to show at what time the damage occurred and which mechanism actually caused it...
March 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29678325/does-hearing-in-response-to-soft-tissue-stimulation-involve-skull-vibrations-a-within-subject-comparison-between-skull-vibration-magnitudes-and-hearing-thresholds
#7
Shai Chordekar, Ronen Perez, Cahtia Adelman, Haim Sohmer, Liat Kishon-Rabin
Hearing can be elicited in response to bone as well as soft-tissue stimulation. However, the underlying mechanism of soft-tissue stimulation is under debate. It has been hypothesized that if skull vibrations were the underlying mechanism of hearing in response to soft-tissue stimulation, then skull vibrations would be associated with hearing thresholds. However, if skull vibrations were not associated with hearing thresholds, an alternative mechanism is involved. In the present study, both skull vibrations and hearing thresholds were assessed in the same participants in response to bone (mastoid) and soft-tissue (neck) stimulation...
April 3, 2018: Hearing Research
https://www.readbyqxmd.com/read/29678313/is-the-amount-of-exposure-to-aggressive-challenging-behaviour-related-to-staff-work-related-well-being-in-intellectual-disability-services-evidence-from-a-clustered-research-design
#8
Samantha Flynn, Richard P Hastings, David Gillespie, Rachel McNamara, Elizabeth Randell
BACKGROUND: Previous research has demonstrated an association between aggressive challenging behaviour (CB) and reductions in work-related well-being for intellectual disability (ID) support staff. Much of this research has used subjective measures of CB. AIMS: To examine whether exposure to aggressive CB is associated with reduced work-related well-being in staff working in ID residential settings across the UK. METHODS AND PROCEDURE: A cross-sectional analysis was undertaken as part of a randomised trial; 186 staff from 100 settings completed questionnaires on their CB self-efficacy, empathy, positive work motivation, and burnout...
April 17, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29678170/self-reported-functional-recovery-after-reconstruction-versus-repair-in-acute-anterior-cruciate-ligament-rupture-rotor-a-randomized-controlled-clinical-trial
#9
Barbara C Boer, Roy A G Hoogeslag, Reinoud W Brouwer, Anna Demmer, Rianne M H A Huis In 't Veld
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction is today's surgical gold standard for ACL rupture. Although it provides satisfactory results, not all patients return to their previous activity level and moreover, early posttraumatic osteoarthritis is not prevented. As such, a renewed interest has emerged in ACL suture repair combined with dynamic augmentation. Compared to ACL reconstruction, the hypothesized advantages of ACL suture repair are earlier return to sports, reduction of early posttraumatic osteoarthritis and preservation of the patient's native ACL tissue and proprioceptive envelope of the knee...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29678024/opportunities-and-pitfalls-in-the-definition-of-data-validity
#10
Jürgen Stausberg, Nils Kuklik, Karl-Heinz Jöckel
Several dimensions of data quality are described in the literature. One overriding aspect is considered to be the extent to which data represent the truth which is captured by data validity. Unfortunately, a common terminology, well defined concepts, and approved measures are missing in regard to data validity. In particular, there is a need to discuss the gold standard as reference for the data at hand and respective measures. Ultimate gold standard would be the state of the patient which itself is subjected to human and personal interpretations...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677745/one-pot-synthesis-of-magnesium-aminoclay-titanium-dioxide-nanocomposites-for-improved-photocatalytic-performance
#11
Vu K H Bui, Duckshin Park, Vinh V Tran, Go-Woon Lee, Seo Yeong Oh, Yun Suk Huh, Young-Chul Lee
TiO2 nanoparticles (NPs) with their excellent photocatalytic performance are among the hottest research subjects for environmental-cleanup applications. In the present work, we developed a method of one-pot synthesis of magnesium aminoclay-titanium dioxide [MgAC-TiO2] nanocomposites in ethanol solution and then treated the obtained nanocomposites in a 350 °C muffle furnace for 3 hours. The obtained X-ray diffraction (XRD) patterns confirmed the growth of the anatase TiO2 NPs in the amorphous MgAC phase. In the scanning electron microscopy (SEM) morphological observation, the MgAC-TiO2 nanocomposites exhibited an aggregate form of 246...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677375/characteristics-of-retinal-structural-and-microvascular-alterations-in-early-type-2-diabetic-patients
#12
Qi Chen, Fan Tan, Yufei Wu, Xiran Zhuang, Chaoming Wu, Yuheng Zhou, Yingzi Li, Dan Cheng, Jianhua Wang, Fan Lu, Meixiao Shen
Purpose: To investigate early retinal structural and microvascular changes in patients with type 2 diabetes mellitus (DM) and to analyze relationships among the retinal structure, microvasculature, and choroid. Methods: Seventy-seven patients with type 2 DM (40 with no diabetic retinopathy [DR], 37 with nonproliferative diabetic retinopathy [NPDR]), and 34 control subjects were enrolled. Spectral-domain optical coherence tomography, operating in radial 18-line mode, obtained macular images of the eight intraretinal layers and the choroid...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677367/stable-microsaccades-and-microsaccade-induced-global-alpha-band-phase-reset-across-the-life-span
#13
Ying Gao, Carl Huber, Bernhard A Sabel
Purpose: To understand the effect of aging on microsaccade functions and brain physiologic responses, we quantified microsaccades and their physiologic correlates (including their interaction with alpha band brain oscillation) in normal subjects of different ages. Methods: Twenty-two normally sighted young (18 to 29 years), 22 middle-aged (31 to 55 years), and 22 elderly subjects (56 to 77 years) participated in this cross-sectional study. Dense array EEG and high-resolution eye-tracking data were simultaneously recorded during a fixation task...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677161/fast-gpu-pcc-a-gpu-based-technique-to-compute-pairwise-pearson-s-correlation-coefficients-for-time-series-data-fmri-study
#14
Taban Eslami, Fahad Saeed
Functional magnetic resonance imaging (fMRI) is a non-invasive brain imaging technique, which has been regularly used for studying brain’s functional activities in the past few years. A very well-used measure for capturing functional associations in brain is Pearson’s correlation coefficient. Pearson’s correlation is widely used for constructing functional network and studying dynamic functional connectivity of the brain. These are useful measures for understanding the effects of brain disorders on connectivities among brain regions...
April 20, 2018: High-throughput
https://www.readbyqxmd.com/read/29676310/comparative-analysis-of-non-absorbable-10-0-nylon-sutures-with-absorbable-10-0-vicryl-sutures-in-pediatric-cataract-surgery
#15
Jyoti Matalia, Pratibha Panmand, Pooja Ghalla
Purpose: The purpose of the study is to compare the efficiency as well as the rate and type of suture-related complications between 10-0 monofilament nylon (Aurolab Nylon Sutures, double arm, Aurolab) and 10-0 polyglactin 910 sutures (Vicryl, single arm, Aurolab) for pediatric cataract surgery. Methods: It is a prospective, comparative study performed in children who underwent surgery for congenital or developmental cataract from March 2013 to February 2016. Patients underwent suturing with either nylon or Vicryl in unilateral cases, but in most bilateral surgeries, one eye received Vicryl sutures while the other eye received nylon...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676066/allergen-specific-immunotherapies-for-food-allergy
#16
REVIEW
Elizabeth Feuille, Anna Nowak-Wegrzyn
With rising prevalence of food allergy (FA), allergen-specific immunotherapy (AIT) for FA has become an active area of research in recent years. In AIT, incrementally increasing doses of inciting allergen are given with the goal to increase tolerance, initially through desensitization, which relies on regular exposure to allergen. With prolonged therapy in some subjects, AIT may induce sustained unresponsiveness, in which tolerance is retained after a period of allergen avoidance. Methods of AIT currently under study in humans include oral, sublingual, epicutaneous, and subcutaneous delivery of modified allergenic protein, as well as via DNA-based vaccines encoding allergen with lysosomal-associated membrane protein I...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675685/laplace-based-modeling-of-fiber-orientation-in-the-tongue
#17
Arnold D Gomez, Nahla Elsaid, Maureen L Stone, Jiachen Zhuo, Jerry L Prince
Mechanical modeling of tongue deformation plays a significant role in the study of breathing, swallowing, and speech production. In the absence of internal joints, fiber orientations determine the direction of sarcomeric contraction and have great influence over real and simulated tissue motion. However, subject-specific experimental observations of fiber distribution are difficult to obtain; thus, models of fiber distribution are generally used in mechanical simulations. This paper describes modeling of fiber distribution using solutions of Laplace equations and compares the effectiveness of this approach against tractography from diffusion tensor magnetic resonance imaging...
April 19, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29675376/clinical-efficacy-of-combined-topical-0-05-cyclosporine-a-and-0-1-sodium-hyaluronate-in-the-dry-eyes-with-meibomian-gland-dysfunction
#18
Ho-Yun Kim, Ji-Eun Lee, Ha-Na Oh, Ju-Whan Song, Sang-Youp Han, Jong-Soo Lee
AIM: To investigate the efficacy of combined topical 0.05% cyclosporine A (CsA; Restasis® , Allergan pharmaceuticals, USA) and 0.1% sodium hyaluronate treatment in dry eyes with meibomian gland dysfunction (MGD). METHODS: In a retrospective analysis, 53 patients (106 eyes) with MGD were enrolled and performed lid warm massage for 10min daily and be instilled preservative free sodium hyaluronate 0.1% eye drops 4 times daily. Patients were divided into subjects treated with topical 0...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675071/pediatric-head-injury-a-study-of-403-cases-in-a-tertiary-care-hospital-in-a-developing-country
#19
Abrar Ahad Wani, Arif Hussain Sarmast, Muzaffar Ahangar, Nayil Khursheed Malik, Sarabjit Singh Chhibber, Sajad Hussain Arif, Altaf Umar Ramzan, Bashir Ahmed Dar, Zulfiqar Ali
Introduction: Traumatic brain injury (TBI) in children is a significant cause of morbidity and mortality worldwide. Falls are the most common type of injury, followed by motor vehicle-related accidents and child abuse. Aims and Objectives: The aim and objective of this study was to elucidate the various modes of injury, prognostic factors, complications, incidence of various modes of injury, and outcome in TBI in pediatric population. Materials and Methods: Patients with TBI, 18 years or less in age, managed in our Department of Neurosurgery, over a period of 2 years, were studied prospectively...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29674845/blood-pressure-response-to-resistance-training-in-hypertensive-and-normotensive-older-women
#20
Dahan da Cunha Nascimento, Cristiane Rocha da Silva, Renato Valduga, Bruno Saraiva, Ivo Vieira de Sousa Neto, Amilton Vieira, Silvana Schwerz Funghetto, Alessandro Oliveira Silva, Samuel da Cunha Oliveira, Guilherme Borges Pereira, Jeffrey M Willardson, Jonato Prestes
Purpose: The purpose of the present study was to identify the variability of blood pressure response to a 10-week resistance training (RT) program in hypertensive and normotensive elderly women. Participants and methods: Twenty-seven untrained hypertensive and 12 normotensive elderly women participated in the present study. A whole-body RT program was performed on two nonconsecutive days per week for 10 weeks. The responsiveness of resting systolic blood pressure (SBP) was determined based on the percent decline between the pre- and post-training time points T1 and T4...
2018: Clinical Interventions in Aging
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