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https://www.readbyqxmd.com/read/28222539/technologies-assessing-limb-bradykinesia-in-parkinson-s-disease
#1
Hasan Hasan, Dilan S Athauda, Thomas Foltynie, Alastair J Noyce
BACKGROUND: The MDS-UPDRS (Movement Disorders Society - Unified Parkinson's Disease Rating Scale) is the most widely used scale for rating impairment in PD. Subscores measuring bradykinesia have low reliability that can be subject to rater variability. Novel technological tools can be used to overcome such issues. OBJECTIVE: To systematically explore and describe the available technologies for measuring limb bradykinesia in PD that were published between 2006 and 2016...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28222396/lawsone-suppresses-azoxymethane-mediated-colon-cancer-in-rats-and-reduces-proliferation-of-dld-1-cells-via-nf-%C3%AE%C2%BAb-pathway
#2
Shi-Bin Wang, Zhenzhou Tao, Ping Li
Lawsone (LS) a colored napthoquinone compound obtained from the plant Lawsonia inermis L. (Lythraceae) is known for its usefulness of being a precursor for synthesis of some anticancer compounds. Literatures support potent anticancer activity of napthoquinone derivatives in human colon cancer, present study evaluates the effect and mechanism of LS on chemical induced colon cancerous rats and human colon cancer DLD-1 cells, the study was supported by endoscopy, histological and immunohistochemistry analysis...
February 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28222345/dc-eeg-recordings-of-mindfulness
#3
Ernst Rodin, Harald Bornfleth, Michael Johnson
OBJECTIVE: To assess the frequency spectrum of the normal waking human eyes-closed EEG while concentrating on a mental task. METHODS: Ten adult normal volunteers listened to a CD encouraging mindfulness for one hour and five minutes while their EEG was recorded on a 128 channel DC based ANT system. The software package BESA Research version 6.1 was used for data analysis. The data were subjected to topographic display, frequency as well as independent component analysis...
January 26, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28222133/maternal-psychological-stress-induced-developmental-disability-neonatal-mortality-and-stillbirth-in-the-offspring-of-wistar-albino-rats
#4
Sakthivel Govindaraj, Annadurai Shanmuganathan, Ravindran Rajan
BACKGROUND: Stress is an inevitable part of life, and maternal stress during the gestational period has dramatic effects in the early programming of the physiology and behavior of offspring. The developmental period is crucial for the well-being of the offspring. Prenatal stress influences the developmental outcomes of the fetus, in part because the developing brain is particularly vulnerable to stress. The etiology of birth defects of the offspring is reported to be 30-40% genetic and 7-10% multifactorial, with the remaining 50% still unknown and also there is no clear cause for neonatal mortality and still-birth...
2017: PloS One
https://www.readbyqxmd.com/read/28221248/early-transcriptomic-changes-in-the-ileal-pouch-provide-insight-into-the-molecular-pathogenesis-of-pouchitis-and-ulcerative-colitis
#5
Yong Huang, Sushila Dalal, Dionysios Antonopoulos, Nathaniel Hubert, Laura H Raffals, Kyle Dolan, Christopher Weber, Jeannette S Messer, Bana Jabri, Albert Bendelac, A Murat Eren, David T Rubin, Mitch Sogin, Eugene B Chang
BACKGROUND: Ulcerative colitis (UC) only involves the colonic mucosa. Yet, nearly 50% of patients with UC who undergo total proctocolectomy with ileal pouch anal anastomosis develop UC-like inflammation of the ileal pouch (pouchitis). By contrast, patients with familial adenomatous polyposis (FAP) with ileal pouch anal anastomosis develop pouchitis far less frequently. We hypothesized that pathogenic events associated with the development of UC are recapitulated by colonic-metaplastic transcriptomic reprogramming of the UC pouch...
March 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28220580/molecular-diagnosis-of-von-willebrand-disease
#6
REVIEW
L Baronciani, A Goodeve, F Peyvandi
The role of molecular characterization in the diagnosis of von Willebrand disease (VWD) is not essential if the patients have been extensively investigated using phenotypic analysis. On the other hand, if some of these phenotype assays are not available, the identification of the mutation causing the disease could be crucial for an accurate diagnosis. Nevertheless, there are several reasons for performing molecular analysis in patients phenotypically well characterized, e.g. to identify the mutation causing VWD can be useful for patients and their family members when prenatal diagnosis is required (type 3 or severe type 2)...
February 20, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28220261/does-a-foot-drop-implant-improve-kinetic-and-kinematic-parameters-in-the-foot-and-ankle
#7
Kiriakos Daniilidis, Eike Jakubowitz, Anna Thomann, Sarah Ettinger, Christina Stukenborg-Colsman, Daiwei Yao
INTRODUCTION: Unlike the drop foot therapy with ortheses, the therapeutic effect of an implantable peroneus nerve stimulator (iPNS) is not well described. IPNS is a dynamic therapy option which is placed directly to the motoric part of the peroneal nerve and evokes a dorsiflexion of the paralysed foot. This retrospective study evaluates the kinematics and kinetics in drop foot patients who were treated with an iPNS. MATERIALS AND METHODS: 18 subjects (mean age 51...
February 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28220200/intraurethral-bulking-agents-for-the-management-of-female-stress-urinary-incontinence-a-systematic-review
#8
REVIEW
Zain A Siddiqui, Hamid Abboudi, Ruairidh Crawford, Shahzad Shah
INTRODUCTION AND HYPOTHESIS: The object of this review was to assess the efficacy and safety of urethral bulking agents (UBA), principally Macroplastique and Bulkamid, in the treatment of female stress urinary incontinence (SUI). METHODS: MEDLINE® and EMBASE® databases were systematically searched up to June 2016. Year of publication, study type, outcome measures, urodynamics before and after the procedure, number of participants, procedure complications, proportion requiring repeat injections or surgical procedures, frequency of follow-up, and results were analysed...
February 21, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28219960/comparison-of-substance-use-subjective-well-being-and-interpersonal-relationships-among-young-people-in-foster-care-and-private-households-a-cross-sectional-analysis-of-the-school-health-research-network-survey-in-wales
#9
Sara Jayne Long, Rhiannon E Evans, Adam Fletcher, Gillian Hewitt, Simon Murphy, Honor Young, Graham F Moore
OBJECTIVE: To investigate the association of living in foster care (FC) with substance use and subjective well-being in a sample of secondary school students (11-16 years) in Wales in 2015/16, and to examine whether these associations are attenuated by the perceived quality of interpersonal relationships. DESIGN: Cross-sectional, population-based health behaviour and lifestyle questionnaire. SETTING AND PARTICIPANTS: Wales, UK; young people who took part in the 2015/16 School Health Research Network (SHRN) questionnaire (n=32 479)...
February 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28219781/adenosine-a2-receptor-activation-ameliorates-mitochondrial-oxidative-stress-upon-reperfusion-through-the-posttranslational-modification-of-ndufv2-subunit-of-complex-i-in-the-heart
#10
Jingman Xu, Xiyun Bian, Yuan Liu, Lan Hong, Tianming Teng, Yuemin Sun, Zhelong Xu
While it is well known that adenosine receptor activation protects the heart from ischemia/reperfusion injury, the precise mitochondrial mechanism responsible for the action remains unknown. This study probed the mitochondrial events associated with the cardioprotective effect of 5'-(N-ethylcarboxamido) adenosine (NECA), an adenosine A2 receptor agonist. Isolated rat hearts were subjected to 30min ischemia followed by 10min of reperfusion, whereas H9c2 cells experienced 20min ischemia and 10min reperfusion...
February 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28219478/assessment-of-the-multi-criteria-evaluation-system-of-the-welfare-quality%C3%A2-protocol-for-growing-pigs
#11
I Czycholl, C Kniese, L Schrader, J Krieter
Animal welfare has become an important subject of public and political debate, leading to the necessity of an objective evaluation system for on-farm use. As welfare is a multi-dimensional concept, it makes sense to use a multi-criteria aggregation system to obtain an overall welfare score. Such an aggregation system is provided by the Welfare Quality® Network. The present paper focusses on the assessment of the multi-criteria evaluation model included in the Welfare Quality® protocol for growing pigs in order to aggregate the animal-based indicators first to criteria, then to principles and finally to an overall welfare score...
February 21, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28219453/a-consult-is-just-a-page-away-a-prospective-observational-study-on-the-impact-of-jinxing-on-call-karma-in-neurosurgery
#12
Holger Joswig, Lauren Zarnett, David A Steven, Martin N Stienen
OBJECTIVE: Our aim was to assess the impact of jinxing on "call karma" in neurosurgery. METHODS: We conducted a prospective observational study on 15 residents on call for the neurosurgery service, recording the total number of admissions, consults, deaths encountered, surgeries performed, hours of sleep and subjective call rating on a numeric rating scale (NRS) of 0-10 in terms of general awfulness. RESULTS: Some 204 on-call nightshifts were analyzed, of which 61 (29...
February 21, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28219440/tau-pet-imaging-present-and-future-directions
#13
REVIEW
Laure Saint-Aubert, Laetitia Lemoine, Konstantinos Chiotis, Antoine Leuzy, Elena Rodriguez-Vieitez, Agneta Nordberg
Abnormal aggregation of tau in the brain is a major contributing factor in various neurodegenerative diseases. The role of tau phosphorylation in the pathophysiology of tauopathies remains unclear. Consequently, it is important to be able to accurately and specifically target tau deposits in vivo in the brains of patients. The advances of molecular imaging in the recent years have now led to the recent development of promising tau-specific tracers for positron emission tomography (PET), such as THK5317, THK5351, AV-1451, and PBB3...
February 20, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28219283/defining-the-relationship-between-health-and-well-being-in-bioethics
#14
David Elliot
Doctors and psychologists often use 'well-being' and 'quality of life' interchangeably, with quality of health overdetermining both. Insights from virtue ethics and St. Thomas Aquinas challenge this. Well-being has a primary 'eudaimonic' dimension, and an accompanying 'subjective' dimension. The 'eudaimonic' consists in a virtuous way of life in which our affective, cognitive, and other capacities are developed in pursuit of worthwhile aims. The 'subjective' consists in attaining and enjoying the goods necessary and fitting to a full human life...
April 2016: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/28219069/predictors-of-bmi-vary-along-the-bmi-range-of-german-adults-results-of-the-german-national-nutrition-survey-ii
#15
Kilson Moon, Carolin Krems, Thorsten Heuer, Alexander Roth, Ingrid Hoffmann
OBJECTIVE: The objective of the study was to identify predictors of BMI in German adults by considering the BMI distribution and to determine whether the association between BMI and its predictors varies along the BMI distribution. METHODS: The sample included 9,214 adults aged 18-80 years from the German National Nutrition Survey II (NVS II). Quantile regression analyses were conducted to examine the association between BMI and the following predictors: age, sports activities, socio-economic status (SES), healthy eating index-NVS II (HEI-NVS II), dietary knowledge, sleeping duration and energy intake as well as status of smoking, partner relationship and self-reported health...
February 21, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28218888/using-clinical-signs-and-symptoms-for-medical-management-of-radiation-casualties-2015-nato-exercise
#16
H Dörr, M Abend, W F Blakely, D L Bolduc, D Boozer, T Costeira, T Dant, A De Amicis, S De Sanctis, M Dondey, M Drouet, F Entine, S Francois, G Gagna, N Guitard, F Hérodin, M Hoefer, A Lamkowski, G La Sala, F Lista, P Loiacono, M Majewski, P Martigne, D Métivier, X Michel, J Pateux, J Pejchal, G Reeves, D Riccobono, Z Sinkorova, L Soyez, D Stricklin, A Tichy, M Valente, C R Woodruff, L Zarybnicka, M Port
The utility of early-phase (≤5 days) radiation-induced clinical signs and symptoms (e.g., vomiting, diarrhea, erythema and changes in blood cell counts) was examined for the prediction of later occurring acute radiation syndrome (ARS) severity and the development of medical management strategies. Medical treatment protocols for radiation accident victims (METREPOL) was used to grade ARS severities, which were assigned response categories (RCs). Data on individuals (n = 191) with mild (RC1, n = 45), moderate (RC2, n = 19), severe (RC3, n = 20) and fatal (RC4, n = 18) ARS, as well as nonexposed individuals (RC0, n = 89) were generated using either METREPOL (n = 167) or the system for evaluation and archiving of radiation accidents based on case histories (SEARCH) database (n = 24), the latter comprised of real-case descriptions...
February 20, 2017: Radiation Research
https://www.readbyqxmd.com/read/28218538/electrochemical-control-of-copper-intercalation-into-nanoscale-bi2se3
#17
Jinsong Zhang, Jie Sun, Yanbin Li, Feifei Shi, Yi Cui
Intercalation of exotic atoms or molecules into the layered materials remains an extensively investigated subject in current physics and chemistry. However, traditionally melt-growth and chemical interaction strategies are either limited by insufficiency of intercalant concentrations or destitute of accurate controllability. Here, we have developed a general electrochemical intercalation method to efficaciously regulate the concentration of zero-valent copper atoms into layered Bi2Se3, followed by a comprehensive experimental characterization and analyses...
February 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28218067/melanocortin-4-receptor-gene-mutations-in-a-group-of-turkish-obese-children-and-adolescents
#18
Selma Tunç, Korcan Demir, Fatma Ajlan Tükün, Cihan Topal, Filiz Hazan, Burcu Sağlam, Özlem Nalbantoğlu, Melek Yıldız, Behzat Özkan
OBJECTIVE: Melanocortin-4 receptor (MC4R) mutations are the most common known cause of monogenic obesity but there is limited data regarding MC4R mutations in Turkish subjects. To determine the prevalence of MC4R mutations in a group of Turkish morbid obese children and adolescents. METHODS: MC4R was sequenced in 47 consecutive morbidly obese children and adolescents (28 girls and 19 boys, aged 1-18 years) who presented during a 1-year period. Inclusion criterion was a BMI ≥120% of the 95th percentile or ≥35 kg/m2...
February 20, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28217948/shrna-mediated-ablation-of-prostate-and-testis-expressed-pate-messenger-rna-results-in-impaired-sperm-function-and-fertility
#19
A Rajesh, S Yenugu
Spermatogenesis and sperm maturation are complex processes mediated by a variety of proteins present in the testicular and epididymal mileu. In the recent years, functional characterization of these proteins is being studied by genetic manipulations that involve targeted over expression or knock down of specific genes. In this study, we adopted FuGENE 6-based in vivo transfection of rat cauda epididymis with pGFP-V-RS plasmid that encodes shRNA to knock down Pate mRNA levels to implicate a possible role for this gene in sperm function...
February 19, 2017: Andrology
https://www.readbyqxmd.com/read/28217934/population-dynamics-of-wild-rodents-induce-stochastic-fadeouts-of-a-zoonotic-pathogen
#20
Giorgio Guzzetta, Valentina Tagliapietra, Sarah E Perkins, Heidi C Hauffe, Piero Poletti, Stefano Merler, Annapaola Rizzoli
Stochastic processes play an important role in the infectious disease dynamics of wildlife, especially in species subject to large population oscillations. Here we study the case of a free ranging population of yellow-necked mice (Apodemus flavicollis) in northern Italy, where circulation of Dobrava-Belgrade hantavirus (DOBV) has been detected intermittently since 2001, until an outbreak emerged in 2010. We analyzed the transmission dynamics of the recent outbreak using a computational model that accounts for seasonal changes of the host population and territorial behavior...
February 19, 2017: Journal of Animal Ecology
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