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https://www.readbyqxmd.com/read/29054675/evidence-of-fatigue-disordered-sleep-and-peripheral-inflammation-but-not-increased-brain-tspo-expression-in-seasonal-allergy-a-11-c-pbr28-pet-study
#1
Sandra Tamm, Simon Cervenka, Anton Forsberg, Johanna Estelius, Johan Grunewald, Pär Gyllfors, Bianka Karshikoff, Eva Kosek, Jon Lampa, Catarina Lensmar, Victoria Strand, Torbjörn Åkerstedt, Christer Halldin, Martin Ingvar, Caroline Olgart Höglund, Mats Lekander
Allergy is associated with non-specific symptoms such as fatigue, sleep problems and impaired cognition. One explanation could be that the allergic inflammatory state includes activation of immune cells in the brain, but this hypothesis has not been tested in humans. The aim of the present study was therefore to investigate seasonal changes in the glial cell marker translocator protein (TSPO), and to relate this to peripheral inflammation, fatigue and sleep, in allergy. We examined 18 patients with severe seasonal allergy, and 13 healthy subjects in and out-of pollen season using positron emission tomography (n = 15/13) and the TSPO radioligand [(11)C]PBR28...
October 17, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29054484/mental-health-and-well-being-among-type-1-diabetes-caregivers-in-india-evidence-from-the-idream-study
#2
Benjamin D Capistrant, Greta Friedemann-Sánchez, Lindsey K Novak, Caroline Zuijdwijk, Graham D Ogle, Sharad Pendsey
AIMS: Although more than half of the world's children with T1D live in developing countries, still little is known about how caregiving for children with T1D affects the parent/caregivers' health in low- and middle-income country settings. METHODS: Caregivers of 178 children with T1D from a specialized diabetes clinic in Maharashtra, India were surveyed. Ordered and standard logistic regression models adjusted for caregiver, household and child characteristics, were fit to estimate the association of caregiving burden (objective caregiving burden and subjective caregiving burden (Zarit Burden Inventory - tertiles)) with caregiver depression (Patient Health Questionnaire [PHQ-9]) and well-being (CDC Unhealthy Days) outcomes...
October 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29054368/an-intermediate-level-of-cd161-expression-defines-a-novel-activated-inflammatory-and-pathogenic-subset-of-cd8-t-cells-involved-in-multiple-sclerosis
#3
Bryan Nicol, Marion Salou, Isabel Vogel, Alexandra Garcia, Emilie Dugast, Jeremy Morille, Stéphanie Kilens, Eric Charpentier, Audrey Donnart, Steven Nedellec, Marylène Jacq-Foucher, Fabienne Le Frère, Sandrine Wiertlewski, Arnaud Bourreille, Sophie Brouard, Laure Michel, Laurent David, Pierre-Antoine Gourraud, Nicolas Degauque, Arnaud B Nicot, Laureline Berthelot, David-Axel Laplaud
Several lines of evidence support a key role for CD8(+) T cells in central nervous system tissue damage of patients with multiple sclerosis. However, the precise phenotype of the circulating CD8(+) T cells that may be recruited from the peripheral blood to invade the CNS remains largely undefined to date. It has been suggested that IL-17 secreting CD8 (Tc17) T cells may be involved, and in humans these cells are characterized by the expression of CD161. We focused our study on a unique and recently described subset of CD8 T cells characterized by an intermediate expression of CD161 as its role in neuroinflammation has not been investigated to date...
October 17, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29054184/under-utilization-of-pacemaker-therapy-for-sinus-node-dysfunction-real-world-data-from-south-asia
#4
C Narasimhan, J Sanyal, R Sethi, Y Kothari, F T N Malik, U Pandurangi, N Khan, S Sahu, J Lande, H Sachanandani, A Naik
OBJECTIVE: Chronic symptomatic sinus node dysfunction (SND), the most common bradyarrhythmia, can be effectively managed by permanent cardiac pacing. Yet the care pathway and barriers to adoption of pacing therapy are not well understood - particularly in low volume implanting countries. The IMPROVE Brady study is a quality improvement initiative being conducted at centers in South Asia, Latin America, and Russia. We assessed the rates of SND diagnosis and pacemaker treatment for SND in the South Asia cohort...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29054014/sex-differences-in-behavioral-and-neurochemical-effects-of-gonadectomy-and-aromatase-inhibition-in-rats
#5
N Kokras, N Pastromas, D Papasava, C de Bournonville, C A Cornil, C Dalla
Aromatase inhibitors, which are widely used for the treatment of estrogen-dependent cancers, have been associated with psychiatric side effects ranging from mania to depression. In the present study, we investigated sex differences in the behavioral and neurochemical effects of aromatase inhibition on male and female, sham-operated or gonadectomized adult rats. Three weeks after surgery, rats received chronic treatment with the aromatase inhibitor letrozole or vehicle and were then subjected to the open field test, which assesses general activity...
October 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29053930/social-dimension-and-complexity-differentially-influence-brain-responses-during-feedback-processing
#6
Daniela M Pfabigan, Marianne Gittenberger, Claus Lamm
Recent research emphasizes the importance of social factors during performance monitoring. Thus, the current study investigated the impact of social stimuli -such as communicative gestures- on feedback processing. Moreover, it addressed a shortcoming of previous studies, which failed to consider stimulus complexity as potential confounding factor. Twenty-four volunteers performed a time estimation task while their electroencephalogram was recorded. Either social complex, social non-complex, non-social complex, or non-social non-complex stimuli were used to provide performance feedback...
October 20, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/29053842/differential-expression-of-water-channel-and-noncoding-rna-biogenesis-related-genes-in-three-lines-of-chickens-under-a-short-term-water-restriction
#7
S Orlowski, J Flees, N Anthony, S Dridi
Genetic selection for high growth rate has resulted in tremendous changes not only in feed efficiency, but also in water consumption between modern broilers and their ancestor jungle fowl (JF). However molecular mechanisms involved in water homeostasis are still not well defined. This study aimed, therefore, to determine the effect of short-term water restriction on the expression of water channel- and noncoding RNA biogenesis-related genes in the kidney and whole blood of JF, broiler population from the 1990s (RB1995), and modern broiler population developed in 2015 (ARB2015)...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29053383/online-activity-offline-sociability-and-life-satisfaction-among-israelis-with-and-without-disabilities
#8
Ayelet Gur, Arie Rimmerman
The Internet has the power to enrich the lives of persons with and without disabilities, and increase independence and subjective well-being. Using path analysis, the study examines the role of Internet use, offline social participation, and connectedness in explaining life satisfaction among people with and without disabilities. Two mediating models have been examined: the first hypothesizes that social participation and connectedness are mediating variables between online use and life satisfaction; the second posits that the association between participation and connectedness to life satisfaction is mediated by Internet use...
October 20, 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/29053338/disaccharides-determination-a-review-of-analytical-methods
#9
Marta Pokrzywnicka, Robert Koncki
Disaccharides are determined mainly for dietetic purposes, hence the most analyses are carried out for food and drink samples. Its content can also be used to profile groceries in order to identify the origin and quality of the products. They also can be an indicator of the rate of metabolism as well as for the control of some technological and biotechnological processes. Unfortunately most of technological analysis are performed with nonselective polarimetry methods. Sugars due to specific physicochemical properties of compounds are difficult to determine with classical analytical techniques...
October 20, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/29053133/-ophthalmic-disorders-as-a-manifestation-of-parkinson-s-disease
#10
N B Chesnokova, T A Pavlenko, M V Ugrumov
Parkinson's disease is a severe neurodegenerative disease accompanied with the degeneration of dopaminergic neurons in the central and peripheral nervous system. The diagnosis of Parkinson's disease can still be made only on the stage of irreversible and nearly total degeneration of the nigrostriatum dopaminergic system and exhaustion of brain compensatory mechanisms that explains the low efficacy of therapy. Ophthalmic pathology is one of the nonmotor symptoms of Parkinson's disease. This can be explained firstly by the fact that eye is a 'peripheral part of brain' and secondly by the involvement of dopaminergic neurons (dopamine-producing cells) that are subject to the selective degeneration during Parkinson's disease in the regulation of visual function in the eye and brain...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29052849/clinical-applications-of-iddsi-framework-for-texture-recommendation-for-dysphagia-patients
#11
Mingsong Su, Gangying Zheng, Yanqiu Chen, Hua Xie, Weijia Han, Qing Yang, Jianqin Sun, Zhihong Lv, Jianshe Chen
Dysphagia is a highly prevalent eating and swallowing disorder among elderly people, impacting negatively on the health and well-being of those afflicted. With increasing populations of elderly people, food industries are under growing pressure to produce appropriately texture-modified food for safe consumption by these vulnerable populations. Recently published IDDSI framework provides a new global guideline on texture modification and standardization for dysphagia patients. This work was designed to test the feasibility of IDDSI framework for clinical applications by assessing the correlation between swallowing capability of dysphagia patients and the IDDSI texture levels...
October 20, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/29052754/development-of-a-method-for-the-detection-of-polystyrene-microplastics-in-paraffin-embedded-histological-sections
#12
Cátia Gonçalves, Marta Martins, Maria H Costa, Pedro M Costa
The concerns about the presence of microplastics (MPs) in marine ecosystems have widely increased in the past years. This is reflected in a growing number of studies addressing the effects of exposure to these materials in indigenous, farmed and even laboratory marine animals subjected to toxicity-oriented bioassays. There have been, however, many constraints in the detection of MPs in biological tissues, as routine histological techniques tend to degrade these materials, which are especially sensitive to organic solvents...
October 20, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29052599/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-a-review-for-pathologists
#13
REVIEW
Raja R Seethala, Zubair W Baloch, Justine A Barletta, Elham Khanafshar, Ozgur Mete, Peter M Sadow, Virginia A LiVolsi, Yuri E Nikiforov, Giovanni Tallini, Lester Dr Thompson
The rising incidence of papillary thyroid carcinoma is linked in part to inclusion of noninvasive follicular variant of papillary thyroid carcinoma. Despite its designation as carcinoma, noninvasive follicular variant of papillary thyroid carcinoma appears to be exceptionally indolent, often over treated by current treatment practices. Additionally, criteria for diagnosis have historically been subjective and challenging. Recently, an international multidisciplinary collaborative group performed a clinicopathologic survey of such cases with extended follow-up and concluded based on the outcome data that a revision in nomenclature was warranted, proposing 'Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP)...
October 20, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29052424/the-moderating-effect-of-subjective-age-on-the-association-between-depressive-symptoms-and-cognitive-functioning-in-korean-older-adults
#14
Eun Young Choi, Young Sun Kim, Hee Yun Lee, Hye Ri Shin, SeolWoo Park, Sung Eun Cho
OBJECTIVES: Depressive symptoms are greatly associated with cognitive impairment in older adults. Recent growing body of literature has reported that the subjective perception of one's own age (subjective age) predicts both cognitive performance and mental well-being in old age. This study aims to examine whether subjective age moderates the association between depressive symptoms and cognitive functioning in a representative sample of Korean older adults. To address this research question, we employed the Stereotype-Embodiment Theory as a theoretical guide...
October 20, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29052333/label-free-quantitative-proteomic-analysis-of-differentially-expressed-membrane-proteins-of-pulmonary-alveolar-macrophages-infected-with-highly-pathogenic-porcine-reproductive-and-respiratory-syndrome-virus-and-its-attenuated-strain
#15
Zehui Qu, Fei Gao, Liwei Li, Yujiao Zhang, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Hao Zheng, Wu Tong, Guoxin Li, Guangzhi Tong
Significant differences exist between the highly pathogenic (HP) porcine reproductive and respiratory syndrome virus (PRRSV) and its attenuated pathogenic (AP) strain in the ability to infect host cells. The mechanisms by which different virulent strains invade host cells remain relatively unknown. In this study, pulmonary alveolar macrophages (PAMs) were infected with HP-PRRSV (HuN4) and AP-PRRSV (HuN4-F112) for 24 h, then harvested and subjected to label-free quantitative mass spectrometry. A total of 2849 proteins were identified, including 95 that were differentially expressed...
October 20, 2017: Proteomics
https://www.readbyqxmd.com/read/29052247/meta-analysis-approaches-to-combine-multiple-gene-set-enrichment-studies
#16
Wentao Lu, Xinlei Wang, Xiaowei Zhan, Adi Gazdar
In the field of gene set enrichment analysis (GSEA), meta-analysis has been used to integrate information from multiple studies to present a reliable summarization of the expanding volume of individual biomedical research, as well as improve the power of detecting essential gene sets involved in complex human diseases. However, existing methods, Meta-Analysis for Pathway Enrichment (MAPE), may be subject to power loss because of (1) using gross summary statistics for combining end results from component studies and (2) using enrichment scores whose distributions depend on the set sizes...
October 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29052225/peripheral-nerve-block-in-ankle-fracture-surgery-a-qualitative-study-of-patients-experiences
#17
M J Henningsen, R Sort, A M Møller, S F Herling
Peripheral nerve blocks are popular as a mode of anaesthesia for limb surgery and their beneficial effects are well documented in elective surgery. However, concerns have been raised about potential rebound pain outweighing the benefits in acute ankle fracture surgery. Furthermore, pain scores and morphine consumption do not provide a full picture, as pain is subjective. To evaluate the clinical usefulness of peripheral nerve blocks, we explored patients' expectations and experiences by means of semi-structured interviews analysed with systematic text condensation...
October 19, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29051989/a-randomized-phase-i-study-to-evaluate-the-safety-tolerability-pharmacokinetics-and-food-effect-of-iguratimod-in-healthy-adult-volunteers
#18
Feng Xiao, Feng Zhang, Ling-Ling Zhang, Wei Wei
OBJECTIVE: The aim of this study was to investigate the safety, maximum tolerated dose and pharmacokinetics (PK) of iguratimod and the effect of food on PK parameters in healthy adult volunteers. METHODS: This phase 1 study consisted of four parts. Part 1 was a single-ascending dose (3.125, 6.25, 12.5, 25, 50, 75 mg) study to assess the maximum tolerated dose and safety of iguratimod. Part 2 was a single-ascending dose study to analyze the pharmacokinetic (PK) parameters of iguratimod; subjects were divided into three groups, with each group receiving iguratimod at a different dose (25, 50 or 75 mg)...
October 19, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29051741/prediction-of-quality-of-life-in-asian-patients-with-schizophrenia-a-cross-sectional-pilot-study
#19
Carol C Choo, Peter K H Chew, Cyrus S Ho, Roger C Ho
BACKGROUND: There has been a shift in mental health services from an emphasis on treatment focused on reducing symptoms to a more holistic approach involving quality of life (QOL) and overall well-being. Many psychosocial variables are associated with QOL but a parsimonious framework is needed to deepen our understanding about the contribution of psychosocial factors in influencing the QOL of Asian patients with schizophrenia in Singapore. The study aimed to address the current gap in literature by analysis of QOL using available predictors in Asian patients with schizophrenia in Singapore...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29051584/radiation-induced-resistance-oscillations-in-2d-electron-systems-with-strong-rashba-coupling
#20
Jesús Iñarrea
We present a theoretical study on the effect of radiation on the mangetoresistance of two-dimensional electron systems with strong Rashba spint-orbit coupling. We want to study the interplay between two well-known effects in these electron systems: the radiation-induced resistance oscillations and the typical beating pattern of systems with intense Rashba interaction. We analytically derive an exact solution for the electron wave function corresponding to a total Hamiltonian with Rashba and radiation terms...
October 19, 2017: Scientific Reports
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