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tildipirosin

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https://www.readbyqxmd.com/read/27027834/clinical-disease-and-lung-lesions-in-calves-experimentally-inoculated-with-histophilus-somni-five-days-after-metaphylactic-administration-of-tildipirosin-or-tulathromycin
#1
Anthony W Confer, Timothy A Snider, Jared D Taylor, Marie Montelongo, Nicholas J Sorensen
OBJECTIVE: To compare clinical disease and lung lesions in calves experimentally inoculated with Histophilus somni 5 days after metaphylactic administration of tildipirosin or tulathromycin. ANIMALS Twenty-four 3-month-old Holstein and Holstein-crossbreed steers. PROCEDURES: Calves were randomly allocated to 3 groups of 8 calves. On day 0, calves in group 1 received tildipirosin (4 mg/kg, SC), calves in group 2 received tulathromycin (2.5 mg/kg, SC), and calves in group 3 received isotonic saline (0...
April 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/26935349/pharmacokinetics-of-tildipirosin-in-pig-tonsils
#2
F Torres, R Santamaria, M Jimenez, R Menjón, A Ibanez, M Collell, O Azlor, L Fraile
The penetration of antimicrobials in pig tonsils is hardly known. The objective of the study was to quantify the tildipirosin (TD) penetration in tonsils. Animals were randomly divided into six groups (control, T1, T2 (1), T2(5), T2(10), and T2(15)) of eight animals. T1 and T2 groups received a dose of 2 and 4 mg of TD/kg bw in one shot (Zuprevo® MSD Animal Health), respectively, and the control group received 2 mL of saline solution. The animals were sacrificed by intravenous administration of pentobarbital sodium 24 h after finishing the treatment for the control, T1, and T2(1) groups, whereas animals of T2(5), T2(10), and T2(15) groups were sacrificed at 5, 10, and 15 days, post-treatment, respectively...
April 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26538405/a-microbiological-assay-to-estimate-the-antimicrobial-activity-of-parenteral-tildipirosin-against-foodborne-pathogens-and-commensals-in-the-colon-of-beef-cattle-and-pigs
#3
M Rose, A Pridmore, A Shaw, C Wilhelm, M Menge, S Kilp, R Röpke, M Nürnberger
Tildipirosin (TIP) is a novel 16-membered-ring macrolide authorized for the treatment of bovine and swine respiratory disease. The pH dependency of macrolide antimicrobial activity is well known. Considering that the pH in the colon contents of growing beef cattle and pigs is usually below pH 7.0, the minimum inhibitory concentrations (MIC) of TIP against foodborne bacterial pathogens such as Campylobacter (C.) coli, C. jejuni and Salmonella enterica and commensal species including Enterococcus (E.) faecalis, E...
June 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/25413993/studies-on-a-suitable-antibiotic-therapy-for-treating-swine-brucellosis
#4
L Dieste-Pérez, L Fraile, M J de Miguel, M Barberán, J M Blasco, P M Muñoz
The aim of this work was developing effective treatments against Brucella suis biovar 2, responsible for swine brucellosis in Europe. MICs for antibiotics used classically in brucellosis and two new macrolides (tulathromycin and tildipirosin) were determined for 33 B. suis biovar 2 field and B. suis reference strains. MIC90 values ranged from 0.01 to 0.25 μg/mL. The best candidates, given alone or combined, were then evaluated in mice. Ten groups (n = 7) of BALB/c mice were inoculated (1 × 10(5) CFU/mouse) with a virulent B...
August 2015: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/25261417/macrolide-resistance-conferred-by-rrna-mutations-in-field-isolates-of-mannheimia-haemolytica-and-pasteurella-multocida
#5
Anders S Olsen, Ralf Warrass, Stephen Douthwaite
OBJECTIVES: To determine how resistance to macrolides is conferred in field isolates of Pasteurella multocida and Mannheimia haemolytica that lack previously identified resistance determinants for rRNA methylation, efflux and macrolide-modifying enzymes. METHODS: Isolates of P. multocida and M. haemolytica identified as being highly resistant (MICs >64 mg/L) to the macrolides erythromycin, gamithromycin, tilmicosin, tildipirosin and tulathromycin were screened by multiplex PCR for the previously identified resistance genes erm(42), msr(E) and mph(E)...
February 2015: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/25125397/performance-characterization-of-a-quantitative-liquid-chromatography-tandem-mass-spectrometric-method-for-12-macrolide-and-lincosamide-antibiotics-in-salmon-shrimp-and-tilapia
#6
Leslie C Dickson
This paper describes an extension and performance characterization of a quantitative confirmatory multi-residue liquid chromatography-tandem mass spectrometric method for residues of macrolide and lincosamide antibiotics, originally validated for application to bovine kidney tissues, to tissues of salmon, shrimp and tilapia. The 12 analytes include clindamycin, erythromycin A, gamithromycin, josamycin, lincomycin, neospiramycin 1, oleandomycin, pirlimycin, spiramycin 1, tildipirosin, tilmicosin and tylosin A...
September 15, 2014: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/24503775/overall-decrease-in-the-susceptibility-of-mycoplasma-bovis-to-antimicrobials-over-the-past-30-years-in-france
#7
Anne V Gautier-Bouchardon, Séverine Ferré, Dominique Le Grand, Agnès Paoli, Emilie Gay, François Poumarat
Mycoplasma (M.) bovis is frequently implicated in respiratory diseases of young cattle worldwide. Today, to combat M. bovis in Europe, only antimicrobial therapy is available, but often fails, leading to important economical losses. The antimicrobial susceptibility of M. bovis is not covered by antimicrobial resistance surveillance networks. The objectives of this study were to identify resistances that were acquired over the last 30 years in France and to determine their prevalence within contemporary strains...
2014: PloS One
https://www.readbyqxmd.com/read/24243906/pulmonary-lesions-and-clinical-disease-response-to-mannheimia-haemolytica-challenge-10-days-following-administration-of-tildipirosin-or-tulathromycin
#8
RANDOMIZED CONTROLLED TRIAL
D E Amrine, B J White, R L Larson, D A Mosier
This clinical trial evaluated the impact of metaphylactic antimicrobial administration 10 d before experimental inoculation with Mannheimia haemolytica (MH) to mitigate pulmonary lesions. Thirty-three crossbreed heifers were procured as a single group and were randomly allocated to 1 of 3 blocks and to treatment, tildipirosin (ZUP; 4 mg/kg) or tulathromycin (DRX; 2.5 mg/kg) or saline (SAL; 1 mL/45.5 kg), within block on arrival at Kansas State University. All trial procedures were staggered by 7-d intervals for each block, resulting in all animals within a block receiving treatment, challenge, and necropsy on the same dates...
January 2014: Journal of Animal Science
https://www.readbyqxmd.com/read/23076759/-new-drugs-for-horses-and-production-animals-in-2011
#9
I U Emmerich
In 2011, three newly developed active pharmaceutical ingredients for horses and food producing animals were released on the German market for veterinary drug products. Two of these new products represent different drug classes of antibiotics, the polypeptide antibiotic Bacitracin (Bacivet™) and the macrolide antibiotic Clorsulon (Levatum®). The third product represents an anticestodal antiparasitic (Tildipirosin, Zuprevo®). Furthermore, three established veterinary active pharmaceutical ingredients were modified to allow their application for additional species...
October 17, 2012: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/22926570/inhibition-of-protein-synthesis-on-the-ribosome-by-tildipirosin-compared-with-other-veterinary-macrolides
#10
COMPARATIVE STUDY
Niels Møller Andersen, Jacob Poehlsgaard, Ralf Warrass, Stephen Douthwaite
Tildipirosin is a 16-membered-ring macrolide developed to treat bacterial pathogens, including Mannheimia haemolytica and Pasteurella multocida, that cause respiratory tract infections in cattle and swine. Here we evaluated the efficacy of tildipirosin at inhibiting protein synthesis on the ribosome (50% inhibitory concentration [IC(50)], 0.23 ± 0.01 μM) and compared it with the established veterinary macrolides tylosin, tilmicosin, and tulathromycin. Mutation and methylation at key rRNA nucleotides revealed differences in the interactions of these macrolides within their common ribosomal binding site...
November 2012: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/22564832/multiplex-pcr-to-identify-macrolide-resistance-determinants-in-mannheimia-haemolytica-and-pasteurella-multocida
#11
Simon Rose, Benoit Desmolaize, Puneet Jaju, Cornelia Wilhelm, Ralf Warrass, Stephen Douthwaite
The bacterial pathogens Mannheimia haemolytica and Pasteurella multocida are major etiological agents in respiratory tract infections of cattle. Although these infections can generally be successfully treated with veterinary macrolide antibiotics, a few recent isolates have shown resistance to these drugs. Macrolide resistance in members of the family Pasteurellaceae is conferred by combinations of at least three genes: erm(42), which encodes a monomethyltransferase and confers a type I MLS(B) (macrolide, lincosamide, and streptogramin B) phenotype; msr(E), which encodes a macrolide efflux pump; and mph(E), which encodes a macrolide-inactivating phosphotransferase...
July 2012: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/22563863/visualizing-the-16-membered-ring-macrolides-tildipirosin-and-tilmicosin-bound-to-their-ribosomal-site
#12
Jacob Poehlsgaard, Niels M Andersen, Ralf Warrass, Stephen Douthwaite
The veterinary antibiotic tildipirosin (20,23-dipiperidinyl-mycaminosyl-tylonolide, Zuprevo) was developed recently to treat bovine and swine respiratory tract infections caused by bacterial pathogens such as Pasteurella multocida. Tildipirosin is a derivative of the naturally occurring compound tylosin. Here, we define drug-target interactions by combining chemical footprinting with structure modeling and show that tildipirosin, tylosin, and an earlier tylosin derivative, tilmicosin (20-dimethylpiperidinyl-mycaminosyl-tylonolide, Micotil), bind to the same macrolide site within the large subunit of P...
August 17, 2012: ACS Chemical Biology
https://www.readbyqxmd.com/read/22500881/pharmacokinetics-of-tildipirosin-in-porcine-plasma-lung-tissue-and-bronchial-fluid-and-effects-of-test-conditions-on-in-vitro-activity-against-reference-strains-and-field-isolates-of-actinobacillus-pleuropneumoniae
#13
M Rose, M Menge, C Bohland, E Zschiesche, C Wilhelm, S Kilp, W Metz, M Allan, R Röpke, M Nürnberger
The pharmacokinetics of tildipirosin (Zuprevo(®) 40 mg/mL solution for injection for pigs), a novel 16-membered-ring macrolide for the treatment for swine respiratory disease (SRD), was investigated in studies collecting blood plasma and postmortem samples of lung tissue and bronchial fluid (BF) from swine. In view of factors influencing the in vitro activity of macrolides, and for the interpretation of tildipirosin pharmacokinetics in relation to minimum inhibitory concentrations (MIC), additional experiments were conducted to study the effects of pH, carbon dioxide-enriched atmosphere, buffers, and serum on tildipirosin MICs for various reference strains and Actinobacillus (A...
April 2013: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/22188102/pharmacokinetics-of-tildipirosin-in-bovine-plasma-lung-tissue-and-bronchial-fluid-from-live-nonanesthetized-cattle
#14
M Menge, M Rose, C Bohland, E Zschiesche, S Kilp, W Metz, M Allan, R Röpke, M Nürnberger
The pharmacokinetics of tildipirosin (Zuprevo(®) 180 mg/mL solution for injection for cattle), a novel 16-membered macrolide for treatment, control, and prevention of bovine respiratory disease, were investigated in studies collecting blood plasma, lung tissue, and in vivo samples of bronchial fluid (BF) from cattle. After single subcutaneous (s.c.) injection at 4 mg/kg body weight, maximum plasma concentration (C(max)) was 0.7 μg/mL. T(max) was 23 min. Mean residence time from the time of dosing to the time of last measurable concentration (MRT(last)) and terminal half-life (T(1/2) ) was 6 and 9 days, respectively...
December 2012: Journal of Veterinary Pharmacology and Therapeutics
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