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https://www.readbyqxmd.com/read/29245144/the-myorobot-a-novel-automated-biomechatronics-system-to-assess-voltage-ca2-biosensors-and-active-passive-biomechanics-in-muscle-and-biomaterials
#1
M Haug, B Reischl, G Prölß, C Pollmann, T Buckert, C Keidel, S Schürmann, M Hock, S Rupitsch, M Heckel, T Pöschel, T Scheibel, C Haynl, L Kiriaev, S I Head, O Friedrich
We engineered an automated biomechatronics system, MyoRobot, for robust objective and versatile assessment of muscle or polymer materials (bio-)mechanics. It covers multiple levels of muscle biosensor assessment, e.g. membrane voltage or contractile apparatus Ca2+ ion responses (force resolution 1µN, 0-10mN for the given sensor; [Ca2+] range ~ 100nM-25µM). It replaces previously tedious manual protocols to obtain exhaustive information on active/passive biomechanical properties across various morphological tissue levels...
December 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29245087/genotyping-of-common-egfr-mutations-in-lung-cancer-patients-by-electrochemical-biosensor
#2
Xiu-Hua Weng, Xiong-Wei Xu, Chang-Lian Wang, Wei-Wei Lin, Ai-Lin Liu, Wei Chen, Xin-Hua Lin
In this study, we constructed a sandwich-type biosensor to identify six common types of mutations in exon 19 of the epidermal growth factor receptor (EGFR) gene, and tested them using tissue samples from patients with non-small cell lung carcinomas. Considering the characteristics that different locations of non-complementary in DNA probes resulting in different hybridization efficiency, we investigated the design of DNA capture probes with varying non-complementary sequence locations in an effort to optimize the selectivity of the biosensor...
December 9, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29244756/recent-progress-in-biosensors-for-environmental-monitoring-a-review
#3
REVIEW
Celine I L Justino, Armando C Duarte, Teresa A P Rocha-Santos
The environmental monitoring has been one of the priorities at the European and global scale due to the close relationship between the environmental pollution and the human health/socioeconomic development. In this field, the biosensors have been widely employed as cost-effective, fast, in situ, and real-time analytical techniques. The need of portable, rapid, and smart biosensing devices explains the recent development of biosensors with new transduction materials, obtained from nanotechnology, and for multiplexed pollutant detection, involving multidisciplinary experts...
December 15, 2017: Sensors
https://www.readbyqxmd.com/read/29243492/a-label-free-platform-for-dopamine-biosensing
#4
Jesús Navarro, Javier Galbán, Susana de Marcos
AIM: This work presents a label-free platform for dopamine (DA) monitoring based on the spectroscopic properties of laccase. RESULTS: Working in batch mode, DA ranging from 25 to 250 μM, can be determined without the interference of norepinephrine and epinephrine. Laccase immobilized in a polyacrylamide film is the basis of a platform for the label-free determination of DA. The linear range goes from 100 to 900 μM with an RSD of 5.3% and a film lifetime of more than 30 measurements...
December 15, 2017: Bioanalysis
https://www.readbyqxmd.com/read/29243083/enhancing-the-copper-sensing-capability-of-escherichia-coli-based-whole-cell-bioreporters-by-genetic-engineering
#5
Yerin Kang, Woonwoo Lee, Sunghoon Kim, Geupil Jang, Bong-Gyu Kim, Youngdae Yoon
Metals are essential to all organisms; accordingly, cells employ numerous genes to maintain metal homeostasis as high levels can be toxic. In the present study, the gene operons responsive to metal(loid)s were employed to generate bacterial cell-based biosensors to detect target metal(loid)s. The cluster of genes related to copper transport known as the cop-operon is regulated by the interaction between the copA promoter region (copAp) and CueR, turning on and off gene expression upon copper ion binding. Therefore, the detection of copper ions could be achieved by inserting a plasmid harboring the fusion of copAp and reporter genes, such as enzymes and fluorescent genes...
December 15, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29241669/cytokine-contributions-to-alterations-of-the-volatile-metabolome-induced-by-inflammation
#6
Patrick Millet, Maryanne Opiekun, Talia Martin, Gary K Beauchamp, Bruce A Kimball
Several studies demonstrate that inflammation affects body odor. Volatile signals associated with inflammation induced by pyrogens like LPS are detectable both by conspecifics and chemical analyses. However, little is known about the mechanisms which translate detection of a foreign molecule or pathogen into a unique body odor, or even how unique that odor may be. Here, we utilized C57BL/6J trained mice to identify the odor of LPS-treated conspecifics to investigate potential pathways between LPS-induced inflammation and changes in body odor, as represented by changes in urine odor...
December 11, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29241061/scfv-modified-graphene-coated-ide-arrays-for-label-free-screening-of-cardiovascular-disease-biomarkers-in-physiological-saline
#7
Lotta E Delle, Vivek Pachauri, Shikha Sharma, Olena Shaforost, Hui Ma, Mohammad Adabi, Rainer Lilischkis, Patrick Wagner, Ronald Thoelen, Norbert Klein, Richard O'Kennedy, Sven Ingebrandt
Fatty-acid binding proteins (FABP) and myeloperoxidases (MPO) are associated with many chronic conditions in humans and considered to be important biomarkers for diagnosis of cardiac diseases. Here we assemble a new electrical biosensor platform based on graphene-coated interdigitated electrode arrays (IDE-arrays) towards ultrafast, label-free screening of heart type-FABP and MPO. Arrays of nanoscale (nanoIDE) and microscale (microIDE) electrode-arrays were fabricated on wafer-scale by combining nanoimprint and photolithography processes...
December 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29240395/narrow-band-gap-conjugated-polyelectrolytes
#8
Qiuhong Cui, Guillermo C Bazan
Two essential structural elements define a class of materials called conjugated polyelectrolytes (CPEs). The first is a polymer framework with an electronically delocalized, π-conjugated structure. This component allows one to adjust desirable optical and electronic properties, for example the range of wavelengths absorbed, emission quantum yields, electron affinity, and ionization potential. The second defining feature is the presence of ionic functionalities, which are usually linked via tethers that can modulate the distance of the charged groups relative to the backbone...
December 14, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29239604/nitrosoreductase-like-nanocatalyst-for-ultrasensitive-and-stable-biosensing
#9
Ponnusamy Nandhakumar, Byeongyoon Kim, Nam-Sihk Lee, Young Ho Yoon, Kwangyeol Lee, Haesik Yang
Enzyme-like nanocatalytic reactions developed for high signal amplification in biosensors are of limited use because of their low reaction rates and/or unwanted side reactions in aqueous electrolyte solutions containing dissolved O2. Herein, we report a nitrosoreductase-like catalytic reaction, employing 4-nitroso-1-naphthol, Pd nanoparticles, and H3N-BH3, which affords a high reaction rate and minimal side reactions, enabling its use in ultrasensitive electrochemical biosensors. 4-Nitroso-1-naphthol was chosen after five hydroxy-nitro(so)arene compounds were compared in terms of high signal and low background levels...
December 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29239408/qcm-nanomagnetic-beads-biosensor-for-lead-ion-detection
#10
Qingli Zhang, Haixia Cui, Xingliang Xiong, Jun Chen, Ying Wang, Jia Shen, Yiting Luo, Longcong Chen
As lead poses a serious threat to humans even in small amounts, all kinds of lead detection sensors with high sensitivity and selectivity are being constantly improved and put forward. In this report, a novel, simple and label-free quartz crystal microbalance (QCM) biosensor is proposed for detecting lead ions (Pb2+). The biosensor takes full advantage of the high specificity of GR-5 DNAzyme to Pb2+ and the high sensitivity of QCM. In particular, nanomagnetic beads (NMBs) are used as a novel and effective mean of signal amplification in the biosensor because of their mass and their ability to enhance the inductive effect, which are very beneficial for both higher sensitivity and a lower detection limit...
December 14, 2017: Analyst
https://www.readbyqxmd.com/read/29239109/shape-controlled-3d-periodic-metal-nanostructures-fabricated-via-nanowelding
#11
Zhi-Jun Zhao, Sang-Ho Shin, Dae-Geun Choi, Sang-Hu Park, Jun-Ho Jeong
A novel method for fabricating 3D metallic nanostructures to be used in polarized color filters based on nanoimprint lithography, electron-beam evaporation, and nanowelding is proposed. The shape of the nanostructures can be controlled by adjusting the temperature for the nanowelding process. Ag nanowires deposited on polymer patterns are accumulated by the nanowelding process to build up diverse 3D nanostructures. The morphologies of the fabricated 3D nanostructures are analyzed using scanning electron microscopy, atomic force microscopy, and focused ion beam; the heating temperature is varied from 90 to 130 °C in steps of 10 °C...
December 14, 2017: Small
https://www.readbyqxmd.com/read/29235863/entrance-effects-induced-rectified-ionic-transport-in-a-nanopore-channel
#12
Yu Ma, Jinxiu Guo, Laibing Jia, Yanbo Xie
The nanofluidic diode, as one of the emerging nanofluidic logic devices, has been used in many fields such as biosensors, energy harvesting and so on. However, the entrance effects of the nanofluidic ionic conductance were less discussed, which can be a crucial factor for the ionic conduction. Here we calculate the ionic conductance as a function of the length-to-pore ratio (L/r), which has a clear boundary between nanopore (surface dominated) and nanochannel (geometry dominated) electrically in diluted salt solution...
December 13, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29235484/paper-based-mos2-nanosheet-mediated-fret-aptasensor-for-rapid-malaria-diagnosis
#13
Alisha Geldert, Kenry, Chwee Teck Lim
There has been growing interest in the development of paper-based biosensors because their simplicity and low cost are attractive for point-of-care diagnosis, especially in low-resource areas. However, only a limited range of paper materials - primarily chromatography papers - have been incorporated into diagnostics thus far. Here, we investigate the performance of different types of paper in order to develop an aptamer- and MoS2 nanosheet-based sensor relying on fluorescence resonance energy transfer (FRET) to signal the presence of a target protein...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233745/retropath2-0-a-retrosynthesis-workflow-for-metabolic-engineers
#14
Baudoin Delépine, Thomas Duigou, Pablo Carbonell, Jean-Loup Faulon
Synthetic biology applied to industrial biotechnology is transforming the way we produce chemicals. However, despite advances in the scale and scope of metabolic engineering, the research and development process still remains costly. In order to expand the chemical repertoire for the production of next generation compounds, a major engineering biology effort is required in the development of novel design tools that target chemical diversity through rapid and predictable protocols. Addressing that goal involves retrosynthesis approaches that explore the chemical biosynthetic space...
December 9, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29233679/graphene-paper-supported-mos2-nanocrystals-monolayer-with-cu-submicron-buds-high-performance-flexible-platform-for-sensing-in-sweat
#15
Zhengyun Wang, Shuang Dong, Mengxi Gui, Muhammad Asif, Wei Wang, Feng Wang, Hongfang Liu
Flexible sweat biosensors are of considerable current interest for the development of wearable smart miniature devices. In this work, we report a novel type of flexible and electrochemical sweat platform fabricated by depositing Cu submicron buds on freestanding graphene paper (GP) carrying MoS2 nanocrystals monolayer for bio-functional detection of glucose and lactate. Quantitative analysis of glucose and lactate was carried out by using amperometric i-t method. Linear ranges were obtained between 5 and 1775 μM for glucose and 0...
December 9, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29233567/obtaining-continuous-brac-bac-estimates-in-the-field-a-hybrid-system-integrating-transdermal-alcohol-biosensor-intellidrink-smartphone-app-and-brac-estimator-software-tools
#16
Susan E Luczak, Ashley L Hawkins, Zheng Dai, Raphael Wichmann, Chunming Wang, I Gary Rosen
Biosensors have been developed to measure transdermal alcohol concentration (TAC), but converting TAC into interpretable indices of blood/breath alcohol concentration (BAC/BrAC) is difficult because of variations that occur in TAC across individuals, drinking episodes, and devices. We have developed mathematical models and the BrAC Estimator software for calibrating and inverting TAC into quantifiable BrAC estimates (eBrAC). The calibration protocol to determine the individualized parameters for a specific individual wearing a specific device requires a drinking session in which BrAC and TAC measurements are obtained simultaneously...
December 2, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29232897/biomimetic-sensors-for-the-senses-towards-better-understanding-of-taste-and-odor-sensation
#17
REVIEW
Chunsheng Wu, Ya-Wen Du, Liquan Huang, Yaron Ben-Shoshan Galeczki, Ayana Dagan-Wiener, Michael Naim, Masha Y Niv, Ping Wang
Taste and smell are very important chemical senses that provide indispensable information on food quality, potential mates and potential danger. In recent decades, much progress has been achieved regarding the underlying molecular and cellular mechanisms of taste and odor senses. Recently, biosensors have been developed for detecting odorants and tastants as well as for studying ligand-receptor interactions. This review summarizes the currently available biosensing approaches, which can be classified into two main categories: in vitro and in vivo approaches...
December 11, 2017: Sensors
https://www.readbyqxmd.com/read/29232842/a-new-laccase-based-biosensor-for-tartrazine
#18
Siti Zulaikha Mazlan, Yook Heng Lee, Sharina Abu Hanifah
Laccase enzyme, a commonly used enzyme for the construction of biosensors for phenolic compounds was used for the first time to develop a new biosensor for the determination of the azo-dye tartrazine. The electrochemical biosensor was based on the immobilization of laccase on functionalized methacrylate-acrylate microspheres. The biosensor membrane is a composite of the laccase conjugated microspheres and gold nanoparticles (AuNPs) coated on a carbon-paste screen-printed electrode. The reaction involving tartrazine can be catalyzed by laccase enzyme, where the current change was measured by differential pulse voltammetry (DPV) at 1...
December 9, 2017: Sensors
https://www.readbyqxmd.com/read/29232614/evaluation-of-carbon-nanotube-based-copper-nanoparticle-composite-for-the-efficient-detection-of-agroviruses
#19
Muhammad Ali Tahir, Sadia Z Bajwa, Shahid Mansoor, Rob W Briddon, Waheed S Khan, Brian E Scheffler, Imran Amin
We report a biosensor that combines the construction of a three-dimensional nanocomposite with electrochemical methods for the detection of viruses in plants. This is the first report, where carbon nanotubes are used as a conductive frame to anchor highly electrolytic agglomerates of copper nanoparticles to detect agroviruses. Morphological analysis of nanocomposite revealed the presence of carbon nanotubes having a diameter of 50-100nm with copper nanoparticles of 20-100nm, attached in the form of bunches...
December 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29228983/characterization-of-interactions-between-hepatitis-c-virus-ns5b-polymerase-annexin-a2-and-rna-effects-on-ns5b-catalysis-and-allosteric-inhibition
#20
Sara M Ø Solbak, Eldar Abdurakhmanov, Anni Vedeler, U Helena Danielson
BACKGROUND: Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients. They risk developing HCV-induced hepatocellular carcinoma (HCC), for which the mechanism remains obscure and therapy is missing. Annexin A2 (AnxA2) has been reported to co-precipitate with the non-structural (NS) HCV proteins NS5B and NS3/NS4A, indicating a role in HCC tumorigenesis and effect on DAA therapy...
December 11, 2017: Virology Journal
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