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https://www.readbyqxmd.com/read/29150328/randomized-phase-2-therapeutic-equivalence-study-of-abiraterone-acetate-fine-particle-formulation-vs-originator-abiraterone-acetate-in-patients-with-metastatic-castration-resistant-prostate-cancer-the-staar-study
#1
Cy A Stein, Richard Levin, Robert Given, Celestia S Higano, Paul Nemeth, Bill Bosch, Jillian Chapas-Reed, Robert Dreicer
BACKGROUND: This multicenter, randomized, open-label, active-controlled study evaluated therapeutic equivalence, steady-state pharmacokinetics, and safety of a novel abiraterone acetate fine particle formulation (AAFP) 500mg plus methylprednisolone vs. the originator AA (OAA) 1000mg plus prednisone in men with metastatic castrate-resistant prostate cancer (mCRPC). The primary endpoint was a comparison of average of serum testosterone levels on treatment days 9 and 10 between groups. METHODS: Men with progressive mCRPC, receiving gonadotropin-releasing hormone agonist or antagonist therapy, and with a serum testosterone level of <50ng/dl were randomized 1:1 to either AAFP 500mg daily plus 4mg methylprednisolone orally twice daily (BID), or OAA 1000mg daily plus 5mg prednisone BID for 84 days...
November 14, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29133503/new-aafp-president-hears-understands-family-physicians-concerns
#2
Sheri Porter
No abstract text is available yet for this article.
November 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28925670/aafp-news-afp-edition
#3
(no author information available yet)
No abstract text is available yet for this article.
August 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925653/aafp-news-afp-edition
#4
(no author information available yet)
No abstract text is available yet for this article.
September 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925649/differences-between-the-aafp-atrial-fibrillation-guideline-and-the-aha-acc-hrs-guideline
#5
Margot L Savoy
No abstract text is available yet for this article.
September 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925646/newly-detected-atrial-fibrillation-aafp-updates-guideline-on-pharmacologic-management
#6
Lisa Hauk
No abstract text is available yet for this article.
September 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28925640/aafp-news-afp-edition
#7
(no author information available yet)
No abstract text is available yet for this article.
September 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28876154/aafp-position-statement-declawing
#8
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28762703/aafp-news-afp-edition
#9
(no author information available yet)
No abstract text is available yet for this article.
July 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28762692/aafp-news-afp-edition
#10
(no author information available yet)
No abstract text is available yet for this article.
August 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28695267/impact-of-an-alternative-steroid-on-the-relative-bioavailability-and-bioequivalence-of-a-novel-versus-the-originator-formulation-of-abiraterone-acetate
#11
Azra Hussaini, Anthony J Olszanski, Cy A Stein, Bill Bosch, Paul Nemeth
PURPOSE: The originator abiraterone acetate (OAA) formulation is used for the treatment of metastatic castration-resistant prostate cancer (mCRPC). This study evaluated the bioavailability and bioequivalence of a novel formulation, abiraterone acetate fine particle (AAFP), versus OAA on a steady-state background of steroids. METHODS: Thirty-seven healthy male subjects were randomized in a crossover design to receive methylprednisolone (4 mg twice daily) or prednisone (5 mg twice daily) for 12 days in Period 1...
July 10, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28694285/aafp-takes-leadership-role-with-launch-of-center-for-diversity-health-equity
#12
Michael Laff
No abstract text is available yet for this article.
July 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28671381/pharmacologic-treatment-of-hypertension-acp-and-aafp-release-recommendations-for-adults-60-years-and-older
#13
Lisa Hauk
No abstract text is available yet for this article.
May 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28425029/comparison-of-a-novel-formulation-of-abiraterone-acetate-vs-the-originator-formulation-in-healthy-male-subjects-two-randomized-open-label-crossover-studies
#14
Ronald Goldwater, Azra Hussaini, Bill Bosch, Paul Nemeth
BACKGROUND AND OBJECTIVE: Abiraterone acetate is approved for the treatment of metastatic castration-resistant prostate cancer. The originator abiraterone acetate (OAA) formulation is poorly absorbed and exhibits large pharmacokinetic variability in abiraterone exposure. Abiraterone acetate fine particle (AAFP) is a proprietary formulation (using SoluMatrix Fine Particle Technology™) designed to increase the oral bioavailability of abiraterone acetate. Here, we report on two phase I studies in healthy male subjects aged 18-50 years...
July 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28418540/guideline-acp-and-aafp-recommend-systolic-bp-targets-based-on-history-and-risk-level-in-adults-%C3%A2-%C3%A2-60-years-of-age
#15
Alena Shantsila, Gregory Y H Lip
No abstract text is available yet for this article.
April 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28409587/management-of-chronic-pain-and-opioid-misuse-a-position-paper-from-the-aafp
#16
Lisa Hauk
No abstract text is available yet for this article.
April 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28376468/family-physicians-play-integral-role-in-emergency-medicine
#17
Gerald C Banks, Anthony W Gerard, Kim Yu, Kim A Bullock
No abstract text is available yet for this article.
January 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28376446/aafp-president-pledges-honest-best-effort-toward-better-future-for-family-physicians
#18
Sheri Porter
No abstract text is available yet for this article.
November 2016: Annals of Family Medicine
https://www.readbyqxmd.com/read/28339076/an-activatable-aptamer-based-fluorescence-probe-for-the-detection-of-hepg2-cells
#19
Zongqiang Lai, Juntao Tan, Ruirong Wan, Jie Tan, Zhenghua Zhang, Zixi Hu, Jieping Li, Wei Yang, Yiwei Wang, Yafeng Jiang, Jian He, Nuo Yang, Xiaoling Lu, Yongxiang Zhao
It is significant to develop a probe with sensitivity and specificity for the detection of cancer cells. The present study aimed to develop an 'activatable' aptamer-based fluorescence probe (AAFP) to detect cancer cells and frozen cancer tissue. This AAFP consisted of two fragments: aptamer TLS11a that targets HepG2 cells, and two short extending complementary DNA sequences with a 5'- and 3'-terminus that make the aptamer in hairpin structure a capable quencher to fluorophore. The ability of the AAFP to bind specifically to cancer cells was assessed using flow cytometry, fluorescence spectroscopy and fluorescence microscopy...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28318213/aafp-news-afp-edition
#20
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2017: American Family Physician
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