Ashraf Hamarneh, Andrew Fu Wah Ho, Heerajnarain Bulluck, Vivek Sivaraman, Federico Ricciardi, Jennifer Nicholas, Hilary Shanahan, Elizabeth A Hardman, Peter Wicks, Manish Ramlall, Robin Chung, John McGowan, Roger Cordery, David Lawrence, Tim Clayton, Bonnie Kyle, Maria Xenou, Cono Ariti, Derek M Yellon, Derek J Hausenloy
Remote ischaemic preconditioning (RIPC) using transient limb ischaemia failed to improve clinical outcomes following cardiac surgery and the reasons for this remain unclear. In the ERIC-GTN study, we evaluated whether concomitant nitrate therapy abrogated RIPC cardioprotection. We also undertook a post-hoc analysis of the ERICCA study, to investigate a potential negative interaction between RIPC and nitrates on clinical outcomes following cardiac surgery. In ERIC-GTN, 185 patients undergoing cardiac surgery were randomized to: (1) Control (no RIPC or nitrates); (2) RIPC alone; (3); Nitrates alone; and (4) RIPC + Nitrates...
June 21, 2022: Basic Research in Cardiology