keyword
https://read.qxmd.com/read/37038219/efficacy-of-remote-ischaemic-preconditioning-on-outcomes-following-non-cardiac-non-vascular-surgery-a-systematic-review-and-meta-analysis
#21
REVIEW
Aikaterini Papadopoulou, Matthew Dickinson, Theophilus L Samuels, Christian Heiss, Lui Forni, Ben Creagh-Brown
BACKGROUND: Remote ischaemic preconditioning (RIPC) has been investigated as a simple intervention to potentially mitigate the ischaemic effect of the surgical insult and reduce postoperative morbidity. This review systematically evaluates the effect of RIPC on morbidity, including duration of hospital stay and parameters reflective of cardiac, renal, respiratory, and hepatic dysfunction following non-cardiac non-vascular (NCNV) surgery. METHODS: The electronic databases PubMed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from their inception date to November 2021...
April 10, 2023: Perioperative Medicine
https://read.qxmd.com/read/36980253/effect-of-remote-ischaemic-preconditioning-on-perioperative-endothelial-dysfunction-in-non-cardiac-surgery-a-randomised-clinical-trial
#22
JOURNAL ARTICLE
Kirsten L Wahlstrøm, Hannah F Hansen, Madeline Kvist, Jakob Burcharth, Jens Lykkesfeldt, Ismail Gögenur, Sarah Ekeloef
Endothelial dysfunction result from inflammation and excessive production of reactive oxygen species as part of the surgical stress response. Remote ischemic preconditioning (RIPC) potentially exerts anti-oxidative and anti-inflammatory properties, which might stabilise the endothelial function after non-cardiac surgery. This was a single centre randomised clinical trial including 60 patients undergoing sub-acute laparoscopic cholecystectomy due to acute cholecystitis. Patients were randomised to RIPC or control...
March 16, 2023: Cells
https://read.qxmd.com/read/36786037/exosomes-for-angiogenesis-induction-in-ischemic-disorders
#23
REVIEW
Kasra Moeinabadi-Bidgoli, Malihe Rezaee, Nikoo Hossein-Khannazer, Amirhesam Babajani, Hamid Asadzadeh Aghdaei, Mandana Kazem Arki, Siamak Afaghi, Hassan Niknejad, Massoud Vosough
Ischaemic disorders are leading causes of morbidity and mortality worldwide. While the current therapeutic approaches have improved life expectancy and quality of life, they are unable to "cure" ischemic diseases and instate regeneration of damaged tissues. Exosomes are a class of extracellular vesicles with an average size of 100-150 nm, secreted by many cell types and considered a potent factor of cells for paracrine effects. Since exosomes contain multiple bioactive components such as growth factors, molecular intermediates of different intracellular pathways, microRNAs and nucleic acids, they are considered as cell-free therapeutics...
February 14, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/36682935/exosomes-as-perioperative-therapeutics-to-limit-organ-injury
#24
EDITORIAL
Andrew Owen, Creed M Stary, Eric R Gross
Perioperative organ injury is a frequent and major complication for the ∼240 million people undergoing surgery worldwide annually. Ischaemic preconditioning is a powerful technique that reduces organ injury in experimental models of heart, lung, gut, brain, and kidney ischaemia-reperfusion injury. However, ischaemic preconditioning has been a challenge to translate into clinical practice. We describe how utilising isolated pre-conditioned exosomes (secreted vesicles containing many cell-survival mediators), some of the translational hurdles of ischaemic preconditioning can be overcome...
March 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36657187/cysteine-hydropersulfide-reduces-lipid-peroxidation-and-protects-against-myocardial-ischaemia-reperfusion-injury-are-endogenous-persulfides-mediators-of-ischaemic-preconditioning
#25
JOURNAL ARTICLE
Kayleigh Griffiths, Tomoaki Ida, Masanobu Morita, Reece J Lamb, Jordan J Lee, Michael P Frenneaux, Jon M Fukuto, Takaaki Akaike, Martin Feelisch, Melanie Madhani
Earlier studies revealed the presence of cysteine persulfide (CysSSH) and related polysulfide species in various mammalian tissues. CysSSH has both antioxidant and oxidant properties, modulates redox-dependent signal transduction and has been shown to mitigate oxidative stress. However, its functional relevance in the setting of myocardial ischaemia-reperfusion injury (IRI) remains unknown. The present study was undertaken to (1) study the dynamics of production and consumption of persulfides under normoxic and hypoxic conditions in the heart, and (2) determine whether exogenous administration of the CysSSH donor, cysteine trisulfide (Cys-SSS-Cys) at the onset of reperfusion rescues functional impairment and myocardial damage by interfering with lipid peroxidation...
January 10, 2023: Redox Biology
https://read.qxmd.com/read/36645250/remote-ischaemic-preconditioning-versus-no-remote-ischaemic-preconditioning-for-vascular-and-endovascular-surgical-procedures
#26
REVIEW
Fuxiang Liang, Shidong Liu, Guangzu Liu, Hongxu Liu, Qi Wang, Bing Song, Liang Yao
BACKGROUND: Despite advances in perioperative care, elective major vascular surgical procedures still carry a significant risk of morbidity and mortality. Remote ischaemic preconditioning (RIPC) is the temporary blocking of blood flow to vascular beds remote from those targeted by surgery. It has the potential to provide local tissue protection from further prolonged periods of ischaemia. However, the efficacy and safety of RIPC in people undergoing major vascular surgery remain unknown...
January 16, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/36497011/extracellular-vesicles-from-human-umbilical-cord-derived-mscs-affect-vessel-formation-in-vitro-and-promote-vegfr2-mediated-cell-survival
#27
JOURNAL ARTICLE
Ana Muñiz-García, Bettina Wilm, Patricia Murray, Michael J Cross
Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) have emerged as novel tools in regenerative medicine. Angiogenesis modulation is widely studied for the treatment of ischaemic diseases, wound healing, and tissue regeneration. Here, we have shown that EVs from human umbilical cord-derived MSCs can affect VEGFR2 signalling, a master regulator of angiogenesis homeostasis, via altering the phosphorylation of AKT. This translates into an inhibition of apoptosis, promoting exclusively cell survival, but not proliferation, in human microvascular endothelial cells...
November 24, 2022: Cells
https://read.qxmd.com/read/36374343/non-responsiveness-to-cardioprotection-by-ischaemic-preconditioning-in-ossabaw-minipigs-with-genetic-predisposition-to-but-without-the-phenotype-of-the-metabolic-syndrome
#28
COMMENT
Petra Kleinbongard, Helmut Raphael Lieder, Andreas Skyschally, Mouhamad Alloosh, Axel Gödecke, Sven Rahmann, Michael Sturek, Gerd Heusch
The translation of successful preclinical and clinical proof-of-concept studies on cardioprotection to the benefit of patients with reperfused acute myocardial infarction has been difficult so far. This difficulty has been attributed to confounders which patients with myocardial infarction typically have but experimental animals usually not have. The metabolic syndrome is a typical confounder. We hypothesised that there may also be a genuine non-responsiveness to cardioprotection and used Ossabaw minipigs which have the genetic predisposition to develop a diet-induced metabolic syndrome, but before they had developed the diseased phenotype...
November 11, 2022: Basic Research in Cardiology
https://read.qxmd.com/read/36369239/the-ischaemic-preconditioning-paradox-and-its-implications-for-islet-isolation-from-heart-beating-and-non-heart-beating-donors
#29
JOURNAL ARTICLE
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R V Johnson
The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia. The present study was aimed to assess the effect of hypoxic preconditioning (HP) performed ex-vivo in islets isolated from heart-beating donor (HBD) and non heart-beating donor (NHBD) rats. After HP purified islets were cultured for 24 h in hypoxia followed by islet characterisation. Post-culture islet yields were significantly lower in sham-treated NHBD than in HBD...
November 11, 2022: Scientific Reports
https://read.qxmd.com/read/36347723/plasma-exosomes-generated-by-ischaemic-preconditioning-are-cardioprotective-in-a-rat-heart-failure-model
#30
JOURNAL ARTICLE
Zhaofei Luo, Xudong Hu, Chao Wu, Jinzhong Chan, Zhong Liu, Chengxiao Guo, Rui Zhu, Li Zhang, Ye Zhang, Shiyun Jin, Shufang He
BACKGROUND: Exosomes released into the plasma after brief cardiac ischaemia mediate subsequent cardioprotection. Whether donor exosomes can provide cardioprotection to recipients with chronic heart failure, which confers the highest perioperative risk, is unknown. We examined whether ischaemic preconditioning (IPC)-induced plasma exosomes exerted cardioprotection after their transfer from normal donors to post-infarcted failing hearts. METHODS: Plasma exosomes were obtained from adult rats after IPC or sham...
January 2023: British Journal of Anaesthesia
https://read.qxmd.com/read/36247436/strategies-for-post-cardiac-surgery-acute-kidney-injury-prevention-a-network-meta-analysis-of-randomized-controlled-trials
#31
JOURNAL ARTICLE
Jia-Jin Chen, Tao Han Lee, George Kuo, Yen-Ta Huang, Pei-Rung Chen, Shao-Wei Chen, Huang-Yu Yang, Hsiang-Hao Hsu, Ching-Chung Hsiao, Chia-Hung Yang, Cheng-Chia Lee, Yung-Chang Chen, Chih-Hsiang Chang
OBJECTS: Cardiac surgery is associated with acute kidney injury (AKI). However, the effects of various pharmacological and non-pharmacological strategies for AKI prevention have not been thoroughly investigated, and their effectiveness in preventing AKI-related adverse outcomes has not been systematically evaluated. METHODS: Studies from PubMed, Embase, and Medline and registered trials from published through December 2021 that evaluated strategies for preventing post-cardiac surgery AKI were identified...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36007332/integrative-analysis-of-the-roles-of-lncrnas-and-mrnas-in-ischaemic-preconditioning-to-alleviate-liver-ischaemia-reperfusion-injury-in-mice
#32
JOURNAL ARTICLE
Yongliang Hua, Yanan Xu, Xinglong Li, Bing Yin, Shounan Lu, Chaoqun Wang, Shanjia Ke, Baolin Qian, Hongjun Yu, Miaoyu Bai, Yong Ma
The objective of our study was to elucidate the possible underlying mechanism for the protective effect of ischaemic preconditioning (IPC) against ischaemia-reperfusion (I/R) injury and to provide new research perspectives of long non-coding RNAs (lncRNAs). In this study, serum and liver tissue samples were collected to measure indexes of liver injury from a mouse liver model in sham, I/R injury and I/R + IPC groups. Furthermore, liver samples from 5 randomly selected mice per group were extracted and subjected to the microarray and subsequent bioinformatics analysis...
October 30, 2022: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/35848989/ischaemic-preconditioning-improves-upper-body-endurance-performance-without-altering-%C3%A2-o-2-kinetics
#33
JOURNAL ARTICLE
D Bellini, C Chapman, D Peden, S P Hoekstra, R A Ferguson, C A Leicht
PURPOSE: Whilst pre-exercise ischaemic preconditioning (IPC) can improve lower-body exercise performance, its impact on upper-limb performance has received little attention. This study examines the influence of IPC on upper-body exercise performance and oxygen uptake (⩒O2 ) kinetics. METHODS: Eleven recreationally-active males (24 ± 2 years) completed an arm-crank graded exercise test to exhaustion to determine the power outputs at the ventilatory thresholds (VT1 and VT2) and ⩒O2peak (40...
July 18, 2022: European Journal of Sport Science
https://read.qxmd.com/read/35796462/kidney-targeted-irradiation-triggers-renal-ischemic-preconditioning-in-mice
#34
JOURNAL ARTICLE
Badr Khbouz, François Lallemand, Arianna Cirillo, Pascal Rowart, David Legouis, Nor Eddine Sounni, Agnès Noël, Pascal De Tullio, Sophie de Seigneux, François Jouret
Renal ischemia-reperfusion (I/R) causes acute kidney injury (AKI). Ischemic preconditioning (IPC) attenuates I/R-associated AKI. Whole body irradiation induces renal IPC in mice. Still, the mechanisms remain largely unknown. Furthermore, the impact of kidney-centered irradiation on renal resistance against I/R has not been studied. Renal irradiation (8.5 Gy) was done in male 8- to 12-wk-old C57bl/6 mice using a small animal radiation therapy device. Left renal I/R was performed by clamping the renal pedicles for 30 min, with simultaneous right nephrectomy, at 7, 14, and 28 days postirradiation...
August 1, 2022: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/35727392/negative-interaction-between-nitrates-and-remote-ischemic-preconditioning-in-patients-undergoing-cardiac-surgery-the-eric-gtn-and-ericca-studies
#35
RANDOMIZED CONTROLLED TRIAL
Ashraf Hamarneh, Andrew Fu Wah Ho, Heerajnarain Bulluck, Vivek Sivaraman, Federico Ricciardi, Jennifer Nicholas, Hilary Shanahan, Elizabeth A Hardman, Peter Wicks, Manish Ramlall, Robin Chung, John McGowan, Roger Cordery, David Lawrence, Tim Clayton, Bonnie Kyle, Maria Xenou, Cono Ariti, Derek M Yellon, Derek J Hausenloy
Remote ischaemic preconditioning (RIPC) using transient limb ischaemia failed to improve clinical outcomes following cardiac surgery and the reasons for this remain unclear. In the ERIC-GTN study, we evaluated whether concomitant nitrate therapy abrogated RIPC cardioprotection. We also undertook a post-hoc analysis of the ERICCA study, to investigate a potential negative interaction between RIPC and nitrates on clinical outcomes following cardiac surgery. In ERIC-GTN, 185 patients undergoing cardiac surgery were randomized to: (1) Control (no RIPC or nitrates); (2) RIPC alone; (3); Nitrates alone; and (4) RIPC + Nitrates...
June 21, 2022: Basic Research in Cardiology
https://read.qxmd.com/read/35694149/a-sting-agonist-preconditions-against-ischaemic-stroke-via-an-adaptive-antiviral-type-1-interferon-response
#36
JOURNAL ARTICLE
Nandini Kundu, Amit Kumar, Carlo Corona, Yingxin Chen, Sonia Seth, Saravanan S Karuppagounder, Rajiv R Ratan
Converging lines of inquiry have highlighted the importance of the Type I antiviral response not only in defending against viruses but also in preconditioning the brain against ischaemic stroke. Despite this understanding, treatments that foster brain resilience by driving antiviral interferon responses have yet to be developed for human use. Studies from our laboratory showed that tilorone, the first human antiviral immunomodulatory agent to be developed, robustly preconditioned against stroke in mice and rats...
2022: Brain communications
https://read.qxmd.com/read/35687060/role-of-nuclear-factor-kappa-b-in-tnf-induced-cytoprotection
#37
JOURNAL ARTICLE
Roisin Kelly-Laubscher, Sarin Somers, Lydia Lacerda, Sandrine Lecour
Ischaemic heart disease (IHD) is a leading cause of death worldwide. Understanding prosurvival signalling pathways that protect against ischaemia-reperfusion injury (IRI) may assist in the development of novel cardioprotective strategies against IHD. In this regard, the transcription factor, nuclear factor kappa-B (NFκB) is activated by tumour necrosis factor (TNF), but its role in TNF-induced cytoprotection is unknown. Therefore, to investigate the role of NFκB in TNF-induced cytoprotection, C2C12 cells were pretreated with TNF (0...
June 8, 2022: Cardiovascular Journal of Africa
https://read.qxmd.com/read/35596644/remote-ischaemic-preconditioning-translating-cardiovascular-benefits-to-humans
#38
JOURNAL ARTICLE
James A Lang, Jahyun Kim
Remote ischaemic preconditioning (RIPC), induced by intermittent periods of limb ischaemia and reperfusion, confers cardiac and vascular protection from subsequent ischaemia-reperfusion (IR) injury. Early animal studies reliably demonstrate that RIPC attenuated infarct size and preserved cardiac tissue. However, translating these adaptations to clinical practice in humans has been challenging. Large clinical studies have found inconsistent results with respect to RIPC eliciting IR injury protection or improving clinical outcomes...
May 21, 2022: Journal of Physiology
https://read.qxmd.com/read/35426434/no-sex-related-differences-in-infarct-size-no-reflow-and-protection-by-ischaemic-preconditioning-in-g%C3%A3-ttingen-minipigs
#39
JOURNAL ARTICLE
Petra Kleinbongard, Helmut Lieder, Andreas Skyschally, Gerd Heusch
AIMS: Female sex has been proposed to be cardioprotective per se. Studies with myocardial ischaemia/reperfusion and infarct size as endpoint have demonstrated cardioprotection in female, castrated male and male pigs. These studies are difficult to compare, given the different pig strains, models, durations of ischaemia and methods of infarct size quantification. The few studies using both female and male pigs reported no differences in infarct size and cardioprotection. We therefore prospectively compared infarct size in Göttingen minipigs undergoing ischaemia/reperfusion (I/R) without and with ischaemic preconditioning (IPC) between female, castrated male and male pigs...
April 15, 2022: Cardiovascular Research
https://read.qxmd.com/read/35407378/remote-ischaemic-preconditioning-in-intra-abdominal-cancer-surgery-ripca-a-pilot-randomised-controlled-trial
#40
JOURNAL ARTICLE
Aikaterini Papadopoulou, Matthew Dickinson, Theophilus L Samuels, Christian Heiss, Julie Hunt, Lui Forni, Ben C Creagh-Brown
There is limited evidence on the effect of remote ischaemic preconditioning (RIPC) following non-cardiac surgery. The aim of this study was to investigate the effect of RIPC on morbidity following intra-abdominal cancer surgery. We conducted a double blinded pilot randomised controlled trial that included 47 patients undergoing surgery for gynaecological, pancreatic and colorectal malignancies. The patients were randomized into an intervention (RIPC) or control group. RIPC was provided by intermittent inflations of an upper limb tourniquet...
March 23, 2022: Journal of Clinical Medicine
keyword
keyword
33401
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.