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ischaemic preconditioning

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https://www.readbyqxmd.com/read/27908607/impact-of-remote-ischaemic-preconditioning-on-major-clinical-outcomes-in-patients-undergoing-cardiovascular-surgery-a-meta-analysis-with-trial-sequential-analysis-of-32-randomised-controlled-trials
#1
Shifei Wang, Hairui Li, Nvqin He, Yili Sun, Shengcun Guo, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin
BACKGROUND: The impact of remote ischaemic preconditioning (RIPC) on major clinical outcomes in patients undergoing cardiovascular surgery remains controversial. We systematically reviewed the available evidence to evaluate the potential benefits of RIPC in such patients. METHODS: PubMed, Embase, and Cochrane Library databases were searched for relevant randomised controlled trials (RCTs) conducted between January 2006 and March 2016. The pooled population of patients who underwent cardiovascular surgery was divided into the RIPC and control groups...
November 17, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27884032/-acute-kidney-injury-remote-ischaemic-preconditioning-a-nephroprotective-strategy
#2
Melanie Meersch, Alexander Zarbock
Acute kidney injury is a common and serious complication with a huge impact on morbidity and short- as well as long-term mortality. Sepsis and major surgeries, especially cardiac surgery, are the most common causes of acute kidney injury. Slight increases of serum-creatinine levels are associated with adverse outcomes highlighting the relevance of the need for nephroprotective strategies to reduce the occurrence of acute kidney injury. Remote ischaemic preconditioning is an intervention consisting of brief episodes of ischaemia and reperfusion at a remote site before subsequent ischaemic insults occur...
November 2016: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/27878916/can-the-outcomes-of-mesenchymal-stem-cell-based-therapy-for-myocardial-infarction-be-improved-providing-weapons-and-armour-to-cells
#3
REVIEW
Andrey A Karpov, Daria V Udalova, Michael G Pliss, Michael M Galagudza
Use of mesenchymal stem cell (MSC) transplantation after myocardial infarction (MI) has been found to have infarct-limiting effects in numerous experimental and clinical studies. However, recent meta-analyses of randomized clinical trials on MSC-based MI therapy have highlighted the need for improving its efficacy. There are two principal approaches for increasing therapeutic effect of MSCs: (i) preventing massive MSC death in ischaemic tissue and (ii) increasing production of cardioreparative growth factors and cytokines with transplanted MSCs...
November 23, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27695018/remote-ischaemic-preconditioning-reduces-myocardial-ischaemic-reperfusion-injury-in-patients-with-st-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#4
https://www.readbyqxmd.com/read/27566809/contrast-induced-nephropathy-in-vascular-surgery
#5
G T C Wong, E Y P Lee, M G Irwin
Contrast induced nephropathy (CIN) is traditionally associated with outpatient imaging studies. More recently, patients afflicted with vascular pathologies are increasingly undergoing endovascular treatments that require the use of iodinated contrast media (CM) agents, thus placing them as risk of developing CIN. As perioperative physicians, anaesthetists should be aware of the risk factors and measures that might minimize acute kidney injury caused by CM. This review evaluates recent data regarding preventive measures against CIN and where possible, places the evidence in the context of the patient receiving endovascular surgical treatment...
September 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27564598/a-systematic-review-and-meta-analysis-of-donor-ischaemic-preconditioning-in-liver-transplantation
#6
Francis P Robertson, Louise J Magill, Graham P Wright, Barry Fuller, Brian R Davidson
Ischaemic preconditioning (IPC) is a strategy to reduce ischaemia-reperfusion (IR) injury. Its benefit in human liver transplantation is unclear. The aim of this study was to analyse the current evidence for donor IPC in liver transplantation. Systematic review and meta-analysis of studies involving IPC of liver transplant donors. Ovid Medline, Embase and Cochrane CENTRAL were searched up until January 2015. Data retrieved included the primary outcomes of 1-year mortality, incidence of primary graft non-function (PGNF) and retransplantation...
August 26, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27448845/liver-graft-preconditioning-preservation-and-reconditioning
#7
Nicholas Gilbo, Giorgia Catalano, Mauro Salizzoni, Renato Romagnoli
Liver transplantation is the successful treatment of end-stage liver disease; however, the ischaemia-reperfusion injury still jeopardizes early and long-term post-transplant outcomes. In fact, ischaemia-reperfusion is associated with increased morbidity and graft dysfunction, especially when suboptimal donors are utilized. Strategies to reduce the severity of ischaemia-reperfusion can be applied at different steps of the transplantation process: organ procurement, preservation phase or before revascularization...
July 9, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27443883/roles-of-exosomes-in-cardioprotection
#8
Lucio Barile, Tiziano Moccetti, Eduardo Marbán, Giuseppe Vassalli
Exosomes are extracellular vesicles of endosomal origin which have emerged as key mediators of intercellular communication. All major cardiac cell types-including cardiomyocytes, endothelial cells, and fibroblasts-release exosomes that modulate cellular functions. Exosomes released from human cardiac progenitor cells (CPCs) are cardioprotective and improve cardiac function after myocardial infarction to an extent comparable with that achieved by their parent cells. Cardiac progenitor cell-derived exosomes are enriched in cardioprotective microRNAs, particularly miR-146a-3p...
July 21, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27406142/ischaemic-preconditioning-does-not-alter-the-determinants-of-endurance-running-performance-in-the-heat
#9
Carl A James, Ashley G B Willmott, Alan J Richardson, Peter W Watt, Neil S Maxwell
PURPOSE: Ischaemic preconditioning (IP) has been shown to be ergogenic for endurance performance in normothermic conditions and alleviate physiological strain under hypoxia, potentially through haemodynamic and/or metabolic mechanisms. Exertional hyperthermia is characterised by competition for blood flow between the muscles and skin, an enhanced metabolic strain and impaired endurance performance. This study investigated the effect of IP on the determinants of endurance performance, through an incremental exercise test in the heat...
September 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27373851/chronic-%C3%AE-1-adrenoceptor-blockade-impairs-ischaemic-tolerance-and-preconditioning-in-murine-myocardium
#10
Louise E See Hoe, Jan M Schilling, Anna R Busija, Kristofer J Haushalter, Victoria Ozberk, Malik M Keshwani, David M Roth, Eugene Du Toit, John P Headrick, Hemal H Patel, Jason N Peart
β-adrenoceptor antagonists are commonly used in ischaemic heart disease (IHD) patients, yet may impair signalling and efficacy of 'cardioprotective' interventions. We assessed effects of chronic β1-adrenoceptor antagonism on myocardial resistance to ischaemia-reperfusion (IR) injury and the ability of cardioprotective interventions [classic ischaemic preconditioning (IPC); novel sustained ligand-activated preconditioning (SLP)] to reduce IR injury in murine hearts. Young male C57Bl/6 mice were untreated or received atenolol (0...
October 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27354052/the-pathophysiology-of-acute-myocardial-infarction-and-strategies-of-protection-beyond-reperfusion-a-continual-challenge
#11
Gerd Heusch, Bernard J Gersh
The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over the last two decades in developed countries, but mortality from STEMI despite widespread access to reperfusion therapy is still substantial as is the development of heart failure, particularly among an expanding older population. In developing countries, the incidence of STEMI is increasing and interventional reperfusion is often not available. We here review the pathophysiology of acute myocardial infarction and reperfusion, notably the temporal and spatial evolution of ischaemic and reperfusion injury, the different modes of cell death, and the resulting coronary microvascular dysfunction...
June 26, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27324242/anaesthetics-and-remote-ischaemic-preconditioning-do-not-stop-the-music-despite-a-yet-unhappy-marriage
#12
EDITORIAL
Jürgen Peters
No abstract text is available yet for this article.
July 2016: Basic Research in Cardiology
https://www.readbyqxmd.com/read/27292534/correlation-between-liver-cell-necrosis-and-circulating-alanine-aminotransferase-after-ischaemia-reperfusion-injuries-in-the-rat-liver
#13
Anders R Knudsen, Kasper J Andersen, Stephen Hamilton-Dutoit, Jens R Nyengaard, Frank V Mortensen
Circulating liver enzymes such as alanine transaminase are often used as markers of hepatocellular damage. Ischaemia/reperfusion (I/R) injury is an inevitable consequence of prolonged liver ischaemia. The aim of this study was to examine the correlation between liver enzymes and volume of liver cell necrosis after ischaemia/reperfusion injuries, using design-unbiased stereological methods. Forty-seven male Wistar rats were subjected to 1 h of partial liver ischaemia, followed by either 4 or 24 h of reperfusion...
April 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27289960/long-term-effects-of-remote-ischaemic-preconditioning-in-high-risk-patients-undergoing-cardiac-surgery-follow-up-of-a-randomised-clinical-trial
#14
A Zarbock, J Kellum, H Van Aken, C Schmidt, S Martens, D Görlich, M Meersch
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27249055/the-role-of-toll-like-receptor-4-tlr4-in-cardiac-ischaemic-reperfusion-injury-cardioprotection-and-preconditioning
#15
Sam Man Lee, Mark Hutchinson, David A Saint
Cardiac ischaemic-reperfusion injury (IRI) remains the primary cause of mortality throughout the developed world. Molecular mechanisms underlying IRI are complex and are often interlinked with each other driving a synergistic response. Toll-like receptor 4 (TLR4), an immunosurveillance receptor, is known to enhance tissue injury during IRI by enhancing the inflammatory response. The release of endogenous components during IRI bind onto TLR4 leading to the activation of multiple signalling kinases. Once this event occurs these proteins are defined as danger associated molecular patterns molecules (DAMPs) or alarmins...
September 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27174591/coupling-of-myocardial-stress-resistance-and-signalling-to-voluntary-activity-and-inactivity
#16
B P Budiono, L E See Hoe, A R Brunt, J N Peart, J P Headrick, L J Haseler
AIMS: We examined coupling of myocardial ischaemic tolerance to physical activity and inactivity, and whether this involves modulation of survival (AKT, AMPK, ERK1/2, HSP27, EGFR) and injury (GSK3β) proteins implicated in ischaemic preconditioning and calorie restriction. METHODS: Proteomic modifications were assessed in ventricular myocardium, and tolerance to 25-min ischaemia in ex vivo perfused hearts from C57Bl/6 mice subjected to 14-day voluntary activity in running-naïve animals (Active); 7 days of subsequent inactivity (Inactive); brief (day 3) restoration of running (Re-Active); or time-matched inactivity...
October 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27164905/9th-hatter-biannual-meeting-position-document-on-ischaemia-reperfusion-injury-conditioning-and-the-ten-commandments-of-cardioprotection
#17
REVIEW
R M Bell, H E Bøtker, R D Carr, S M Davidson, J M Downey, D P Dutka, G Heusch, B Ibanez, R Macallister, C Stoppe, M Ovize, A Redington, J M Walker, D M Yellon
In the 30 years since the original description of ischaemic preconditioning, understanding of the pathophysiology of ischaemia/reperfusion injury and concepts of cardioprotection have been revolutionised. In the same period of time, management of patients with coronary artery disease has also been transformed: coronary artery and valve surgery are now deemed routine with generally excellent outcomes, and the management of acute coronary syndromes has seen decade on decade reductions in cardiovascular mortality...
July 2016: Basic Research in Cardiology
https://www.readbyqxmd.com/read/27082229/mending-a-broken-heart-but-breaking-the-kidney
#18
REVIEW
Annette L Mazzone, Robert A Baker, Jonathan M Gleadle
The incidence of acute kidney injury (AKI) is a frequent and serious complication of cardiac surgery. In 2013, 95% of cardiac surgical procedures performed in Australia and New Zealand used cardiopulmonary bypass (CPB). AKI following CPB is well known, yet the perioperative factors contributing to its development are incompletely understood. AKI following CPB has significant implications on both short-term and long-term outcomes. The techniques for conducting CPB have evolved, moving towards evidence-based practice; however, there is still no generally accepted definition of optimal perfusion and its conduct...
October 2016: Nephrology
https://www.readbyqxmd.com/read/27076969/remote-preconditioning-and-cardiac-surgery-regrouping-after-remote-ischemic-preconditioning-for-heart-surgery-ripheart-and-effect-of-remote-ischemic-preconditioning-on-clinical-outcomes-in-patients-undergoing-coronary-artery-bypass-surgery-ericca
#19
Cherry X Cheung, Donagh A Healy, Stewart R Walsh
Remote ischaemic preconditioning (RIPC) is an attractive cardioprotective strategy. Although results from animal studies and phase II study on humans are convincing, it cannot have a role in clinical practice until benefits in clinical outcomes are proven in phase III study. Two phase III studies were recently published [Remote Ischemic Preconditioning for Heart Surgery (RIPHeart) and Effect of Remote Ischemic Preconditioning on Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Surgery (ERICCA)] and this article discusses their design, results and implications...
March 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27072670/combination-of-ischemic-preconditioning-and-postconditioning-can-minimise-skin-flap-loss-experimental-study
#20
Arzu Akcal, Selami Serhat Sirvan, Semra Karsidag, Tahsin Görgülü, Mehmet Akif Akcal, Aysim Ozagari, Soner Tatlidede
OBJECTIVES: Ischaemic preconditioning and postconditioning, which consist of one or a series of short ischaemic events. This study aimed to determine the efficiency of post-conditioning a flap in the minimisation of flap loss after a preconditioned skin flap. METHODS: The rats were divided into five groups: sham group, control group, pre-con group, post-con group, and pre + post-con group. On postoperative days 3 and 7, the entire flaps along with the margins of necrosis were traced onto transparent sheets...
August 2016: Journal of Plastic Surgery and Hand Surgery
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