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https://www.readbyqxmd.com/read/29334576/cheek-volumization-and-nasolabial-folds
#1
Donald S Mowlds, Val Lambros
The impression that cheek filling results in longitudinal shortening ("lift") of the skin and elevation of the nasolabial crease(NLC) or nasolabial fold (NLF) has become common within the facial injection community, but remains unsubstantiated. In this study, seventy-seven patients were evaluated pre and post-injection injection of the cheeks with an Hyaluronic Acid filler using a 3-dimensional camera system. A constant pattern of skin expansion away from the center of the injection and perpendicular to the surface of the skin was observed...
January 10, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29334370/scaffolds-that-mimic-antigen-presenting-cells-enable-ex-vivo-expansion-of-primary-t-cells
#2
Alexander S Cheung, David K Y Zhang, Sandeep T Koshy, David J Mooney
Therapeutic ex vivo T-cell expansion is limited by low rates and T-cell products of limited functionality. Here we describe a system that mimics natural antigen-presenting cells (APCs) and consists of a fluid lipid bilayer supported by mesoporous silica micro-rods. The lipid bilayer presents membrane-bound cues for T-cell receptor stimulation and costimulation, while the micro-rods enable sustained release of soluble paracrine cues. Using anti-CD3, anti-CD28, and interleukin-2, we show that the APC-mimetic scaffolds (APC-ms) promote two- to tenfold greater polyclonal expansion of primary mouse and human T cells compared with commercial expansion beads (Dynabeads)...
January 15, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29334336/engineering-mechanical-microenvironment-of-macrophage-and-its-biomedical-applications
#3
Jing Li, Yuhui Li, Bin Gao, Chuanguang Qin, Yining He, Feng Xu, Hui Yang, Min Lin
Macrophages are the most plastic cells in the hematopoietic system and can be widely found in almost all tissues. Recently studies have shown that mechanical cues (e.g., matrix stiffness and stress/strain) can significantly affect macrophage behaviors. Although existing reviews on the physical and mechanical cues that regulate the macrophage's phenotype are available, engineering mechanical microenvironment of macrophages in vitro as well as a comprehensive overview and prospects for their biomedical applications (e...
January 15, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29333873/survey-regarding-the-05-blood-alcohol-concentration-limit-for-driving-in-the-united-states
#4
Dary D Fiorentino, Brian D Martin
STRUCTURED ABSTRACT Background: On May 14, 2013, the National Transportation Safety Board ("NTSB") proposed that states lower the blood alcohol concentration ("BAC") illegal limit from .08 g/dL to .05 g/dL (also referred to as the ".08 law" and "the .05 limit," respectively). In March of 2017, this recommendation was signed into law in the State of Utah. OBJECTIVE: The objective of this survey is to investigate perceptions regarding enforcement of the .05 g/dL BAC limit. METHOD: Opinions of law enforcement officers, prosecutors, and defense attorneys were obtained through a series of questionnaires and focus groups...
January 15, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29333748/near-infrared-light-sensitive-polyvinyl-alcohol-hydrogel-photoresist-for-spatiotemporal-control-of-cell-instructive-3d-microenvironments
#5
Xiao-Hua Qin, Xiaopu Wang, Markus Rottmar, Bradley J Nelson, Katharina Maniura-Weber
Advanced hydrogel systems that allow precise control of cells and their 3D microenvironments are needed in tissue engineering, disease modeling, and drug screening. Multiphoton lithography (MPL) allows true 3D microfabrication of complex objects, but its biological application requires a cell-compatible hydrogel resist that is sufficiently photosensitive, cell-degradable, and permissive to support 3D cell growth. Here, an extremely photosensitive cell-responsive hydrogel composed of peptide-crosslinked polyvinyl alcohol (PVA) is designed to expand the biological applications of MPL...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29333722/cardiovascular-adjustments-during-anticipated-postural-changes
#6
Neesirg M Patel, Ethan A G Baker, Samuel R Wittman, Isaiah C Engstrom, George H Bourdages, Andrew A McCall, Derek M Miller, Bill J Yates
It is well-documented that feedforward cardiovascular responses occur at the onset of exercise, but it is unclear if such responses are associated with other types of movements. In this study, we tested the hypothesis that feedforward cardiovascular responses occur when a passive (imposed) 60° head-up tilt is anticipated, such that changes in heart rate and carotid artery blood flow (CBF) commence prior to the onset of the rotation. A light cue preceded head-up tilts by 10 sec, and heart rate and CBF were determined for 5-sec time periods prior to and during tilts...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29333326/evaluation-of-the-periodontal-regenerative-properties-of-patterned-human-periodontal-ligament-stem-cell-sheets
#7
Joong-Hyun Kim, Seok-Yeong Ko, Justin Ho Lee, Deok-Ho Kim, Jeong-Ho Yun
Purpose: The aim of this study was to determine the effects of patterned human periodontal ligament stem cell (hPDLSC) sheets fabricated using a thermoresponsive substratum. Methods: In this study, we fabricated patterned hPDLSC sheets using nanotopographical cues to modulate the alignment of the cell sheet. Results: The hPDLSCs showed rapid monolayer formation on various surface pattern widths. Compared to cell sheets grown on flat surfaces, there were no significant differences in cell attachment and growth on the nanopatterned substratum...
December 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29333059/innate-food-aversions-and-culturally-transmitted-food-taboos-in-pregnant-women-in-rural-southwest-india-separate-systems-to-protect-the-fetus
#8
Caitlyn D Placek, Purnima Madhivanan, Edward H Hagen
Pregnancy increases women's nutritional requirements, yet causes aversions to nutritious foods. Most societies further restrict pregnant women's diet with food taboos. Pregnancy food aversions are theorized to protect mothers and fetuses from teratogens and pathogens or increase dietary diversity in response to resource scarcity. Tests of these hypotheses have had mixed results, perhaps because many studies are in Westernized populations with reliable access to food and low exposure to pathogens. If pregnancy food aversions are adaptations, however, then they likely evolved in environments with uncertain access to food and high exposure to pathogens...
November 2017: Evolution and Human Behavior: Official Journal of the Human Behavior and Evolution Society
https://www.readbyqxmd.com/read/29332672/motivational-factors-associated-with-drowsy-driving-behavior-a-qualitative-investigation-of-college-students
#9
Kenneth H Beck, Clark J Lee, Talia Weiner
OBJECTIVES: This qualitative investigation sought to identify the motivational factors that contribute to drowsy driving in college students and to discover important messaging strategies that may help prevent or reduce this behavior in this population. DESIGN: Four focus groups of college students. SETTING: A large university in the Washington, DC, metropolitan area during the Fall 2016 term. PARTICIPANTS: Twenty-six undergraduate students between the ages of 18 and 25 years...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29332229/sociability-modifies-dogs-sensitivity-to-biological-motion-of-different-social-relevance
#10
Yuko Ishikawa, Daniel Mills, Alexander Willmott, David Mullineaux, Kun Guo
Preferential attention to living creatures is believed to be an intrinsic capacity of the visual system of several species, with perception of biological motion often studied and, in humans, it correlates with social cognitive performance. Although domestic dogs are exceptionally attentive to human social cues, it is unknown whether their sociability is associated with sensitivity to conspecific and heterospecific biological motion cues of different social relevance. We recorded video clips of point-light displays depicting a human or dog walking in either frontal or lateral view...
January 13, 2018: Animal Cognition
https://www.readbyqxmd.com/read/29331767/lessons-from-simple-marine-models-on-the-bacterial-regulation-of-eukaryotic-development
#11
REVIEW
Arielle Woznica, Nicole King
Molecular cues from environmental bacteria influence important developmental decisions in diverse marine eukaryotes. Yet, relatively little is understood about the mechanisms underlying these interactions, in part because marine ecosystems are dynamic and complex. With the help of simple model systems, including the choanoflagellate Salpingoeca rosetta, we have begun to uncover the bacterial cues that shape eukaryotic development in the ocean. Here, we review how diverse bacterial cues-from lipids to macromolecules-regulate development in marine eukaryotes...
January 10, 2018: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29331727/individual-variation-in-working-memory-is-associated-with-fear-extinction-performance
#12
Daniel M Stout, Dean T Acheson, Tyler M Moore, Ruben C Gur, Dewleen G Baker, Mark A Geyer, Victoria B Risbrough
PTSD has been associated consistently with abnormalities in fear acquisition and extinction learning and retention. Fear acquisition refers to learning to discriminate between threat and safety cues. Extinction learning reflects the formation of a new inhibitory-memory that competes with a previously learned threat-related memory. Adjudicating the competition between threat memory and the new inhibitory memory during extinction may rely, in part, on cognitive processes such as working memory (WM). Despite significant shared neural circuits and signaling pathways the relationship between WM, fear acquisition, and extinction is poorly understood...
January 5, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29330906/generating-retinoic-acid-gradients-by-local-degradation-during-craniofacial-development-one-cell-s-cue-is-another-cell-s-poison
#13
REVIEW
Aditi Dubey, Rebecca E Rose, Drew R Jones, Jean-Pierre Saint-Jeannet
Retinoic acid (RA) is a vital morphogen for early patterning and organogenesis in the developing embryo. RA is a diffusible, lipophilic molecule that signals via nuclear RA receptor heterodimeric units that regulate gene expression by interacting with RA response elements in promoters of a significant number of genes. For precise RA signaling, a robust gradient of the morphogen is required. The developing embryo contains regions that produce RA, and specific intracellular concentrations of RA are created through local degradation mediated by Cyp26 enzymes...
January 13, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29330694/volatile-compounds-from-beneficial-or-pathogenic-bacteria-differentially-regulate-root-exudation-transcription-of-iron-transporters-and-defense-signaling-pathways-in-sorghum-bicolor
#14
Erasto Hernández-Calderón, Maria Elizabeth Aviles-Garcia, Diana Yazmín Castulo-Rubio, Lourdes Macías-Rodríguez, Vicente Montejano Ramírez, Gustavo Santoyo, José López-Bucio, Eduardo Valencia-Cantero
Our results show that Sorghum bicolor is able to recognize bacteria through its volatile compounds and differentially respond to beneficial or pathogens via eliciting nutritional or defense adaptive traits. Plants establish beneficial, harmful, or neutral relationships with bacteria. Plant growth promoting rhizobacteria (PGPR) emit volatile compounds (VCs), which may act as molecular cues influencing plant development, nutrition, and/or defense. In this study, we compared the effects of VCs produced by bacteria with different lifestyles, including Arthrobacter agilis UMCV2, Bacillus methylotrophicus M4-96, Sinorhizobium meliloti 1021, the plant pathogen Pseudomonas aeruginosa PAO1, and the commensal rhizobacterium Bacillus sp...
January 12, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29330680/the-illusion-of-control-sequential-dependencies-underlie-contingent-attentional-capture
#15
Greg Huffman, Victoria M Antinucci, Jay Pratt
The degree to which humans have top-down control over which information they process remains a central debate within the attention literature. Most of the evidence supporting the top-down control of visuospatial attention has come from cueing paradigms in which target stimuli are preceded by cues that are similar or dissimilar from the target. These studies find that the cues similar to targets capture attention, but dissimilar cues do not, suggesting the top-down control of attention. Here, we used a modified cueing paradigm to investigate an alternative possibility that the cue type differences are due to sequential dependency effects occurring between cue and target processing rather than the top-down control of attention...
January 12, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29330595/consistency-not-speed-temporal-regularity-as-a-metacognitive-cue
#16
Lisa M Stevenson, Richard A Carlson
We examined the hypothesis that skilled performance is monitored on the basis of fluency, where fluency is operationally defined as temporal regularity or rhythmicity rather than speed. Since error is often associated with variable timing, we tested the possibility that people use varied timing as a metacognitive cue. Using a sequential counting task, which may be representative of the broader class of skilled, multi-step tasks, we found that shifting between irregular and regular timing led to greater confidence ratings when the timing associated with the task was regular...
January 12, 2018: Psychological Research
https://www.readbyqxmd.com/read/29330559/a-post-translational-balancing-act-the-good-and-the-bad-of-sumoylation-in-pancreatic-islets
#17
EDITORIAL
Patrick E MacDonald
Post-translational modification of proteins contributes to the control of cell function and survival. The balance of these in insulin-producing pancreatic beta cells is important for the maintenance of glucose homeostasis. Protection from the damaging effects of reactive oxygen species is required for beta cell survival, but if this happens at the expense of insulin secretory function then the ability of islets to respond to changing metabolic conditions may be compromised. In this issue of Diabetologia, He et al ( https://doi...
January 12, 2018: Diabetologia
https://www.readbyqxmd.com/read/29330498/replication-of-biocompatible-nanotopographic-surfaces
#18
Xiaoyu Sun, Matt J Hourwitz, Eleni M Baker, B U Sebastian Schmidt, Wolfgang Losert, John T Fourkas
The ability of cells to sense and respond to nanotopography is being implicated as a key element in many physiological processes such as cell differentiation, immune response, and wound healing, as well as in pathologies such as cancer metastasis. To understand how nanotopography affects cellular behaviors, new techniques are required for the mass production of biocompatible, rigid nanotopographic surfaces. Here we introduce a method for the rapid and reproducible production of biocompatible, rigid, acrylic nanotopographic surfaces, and for the functionalization of the surfaces with adhesion-promoting molecules for cell experiments...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330334/detection-of-heterozygous-mutation-in-hook-microtubule-tethering-protein-1-in-three-patients-with-decapitated-and-decaudated-spermatozoa-syndrome
#19
Huixing Chen, Yong Zhu, Zijue Zhu, Erlei Zhi, Keming Lu, Xiaobo Wang, Feng Liu, Zheng Li, Weiliang Xia
BACKGROUND: The mechanism of intramanchette transport is crucial to the transformation of sperm tail and the nuclear condensation during spermiogenesis. Although few dysfunctional proteins could result in abnormal junction between the head and tail of spermatozoon, little is known about the genetic cues in this process. OBJECTIVE: Based on patients with severe decapitated and decaudated spermatozoa (DDS) syndrome, the study aimed to validate whether new mutation exists on their Hook microtubule-tethering protein 1 (HOOK1) genes and follow their results of assisted reproduction treatment (ART)...
January 12, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29330086/learning-profitable-habitat-types-by-juvenile-crayfish
#20
Taylor M Johnson, Adam L Crane
Habitat selection is fundamentally important to animal ecology, and animals that can learn about habitats can increase the probability of avoiding detection by predators or quickly finding food. Here, we tested whether juveniles of the red swamp crayfish, Procambarus clarkii, can learn preference for habitat types based on experience with food availability. Crayfish were housed in arenas with two habitat types, half leaf habitat and half rock habitat. Over several days, crayfish were fed consistently in one of the habitat types...
January 9, 2018: Behavioural Processes
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