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https://www.readbyqxmd.com/read/28231640/mind-the-gap-mechanisms-regulating-the-endothelial-barrier
#1
REVIEW
Mariya Y Radeva, Jens Waschke
The endothelial barrier consists of intercellular contacts localized in the cleft between endothelial cells, which is covered by the glycocalyx in a sieve-like manner. Both types of barrier-forming junctions, i.e. the adherens junction (AJ) serving mechanical anchorage and mechanotransduction and the tight junction (TJ) sealing the intercellular space to limit paracelullar permeability, are tethered to the actin cytoskeleton. Under resting conditions, the endothelium thereby builds a selective layer controlling the exchange of fluid and solutes with the surrounding tissue...
February 23, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28231626/default-mode-network-deactivation-to-smoking-cue-relative-to-food-cue-predicts-treatment-outcome-in-nicotine-use-disorder
#2
Claire E Wilcox, Eric D Claus, Vince D Calhoun, Srinivas Rachakonda, Rae A Littlewood, Jessica Mickey, Pamela B Arenella, Natalie Goodreau, Kent E Hutchison
Identifying predictors of treatment outcome for nicotine use disorders (NUDs) may help improve efficacy of established treatments, like varenicline. Brain reactivity to drug stimuli predicts relapse risk in nicotine and other substance use disorders in some studies. Activity in the default mode network (DMN) is affected by drug cues and other palatable cues, but its clinical significance is unclear. In this study, 143 individuals with NUD (male n = 91, ages 18-55 years) received a functional magnetic resonance imaging scan during a visual cue task during which they were presented with a series of smoking-related or food-related video clips prior to randomization to treatment with varenicline (n = 80) or placebo...
February 23, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28231508/regulating-dynamic-signaling-between-hematopoietic-stem-cells-and-niche-cells-via-a-hydrogel-matrix
#3
Bhushan P Mahadik, Narayanan A K Bharadwaj, Randy H Ewoldt, Brendan A C Harley
Hematopoietic stem cells (HSC) reside in unique bone marrow niches and are influenced by signals from surrounding cells, the extracellular matrix (ECM), ECM-bound or diffusible biomolecules. Here we describe the use of a three-dimensional hydrogel to alter the balance of HSC-generated autocrine feedback and paracrine signals generated by co-cultured niche-associated cells. We report shifts in HSC proliferation rate and fate specification in the presence of lineage positive (Lin(+)) niche cells. Hydrogels promoting autocrine feedback enhanced expansion of early hematopoietic progenitors while paracrine signals from Lin(+) cells increased myeloid differentiation...
February 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28231459/multisensory-conflict-resolution-should-i-stay-or-should-i-go
#4
Daniel B Polley
Swift action is often required in the face of indeterminate sensory evidence. In this issue of Neuron, Song et al. (2017) describe an inhibitory circuit in the posterior parietal cortex that evaluates conflicting auditory and visual cues and supports resolute perceptual decision making.
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28231041/feasibility-pilot-of-a-randomized-faith-based-intervention-to-reduce-secondhand-smoke-exposure-among-korean-americans
#5
Suzanne C Hughes, Isabel Corcos, Melbourne Hovell, C Richard Hofstetter
INTRODUCTION: Interventions are needed to prevent exposure to secondhand smoke (SHS), which persists in certain immigrant enclaves, including Koreans in the United States. A faith-based and culturally acceptable intervention was developed and pilot tested in collaboration with Korean churches to address SHS exposure among people of Korean descent. METHODS: A pilot cluster randomized intervention trial was conducted with 11 Korean churches in southern California and 75 Korean adults who were exposed to SHS...
February 23, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28230894/diagnosing-crime-and-diagnosing-disease-bias-reduction-strategies-in-the-forensic-and-clinical-sciences
#6
Joseph J Lockhart, Saty Satya-Murti
Cognitive effort is an essential part of both forensic and clinical decision-making. Errors occur in both fields because the cognitive process is complex and prone to bias. We performed a selective review of full-text English language literature on cognitive bias leading to diagnostic and forensic errors. Earlier work (1970-2000) concentrated on classifying and raising bias awareness. Recently (2000-2016), the emphasis has shifted toward strategies for "debiasing." While the forensic sciences have focused on the control of misleading contextual cues, clinical debiasing efforts have relied on checklists and hypothetical scenarios...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230399/not-all-probabilities-are-equivalent-evidence-from-orientation-versus-spatial-probability-learning
#7
Syaheed B Jabar, Britt Anderson
Frequently targets are detected faster, probable locations searched earlier, and likely orientations estimated more precisely. Are these all consequences of a single, domain-general "attentional" effect? To examine this issue, participants were shown brief instances of spatial gratings, and were tasked to draw their location and orientation. Unknown to participants, either the location or orientation probability of these gratings were manipulated. While orientation probability affected the precision of orientation reports, spatial probability did not...
February 23, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28230397/weighted-integration-suggests-that-visual-and-tactile-signals-provide-independent-estimates-about-duration
#8
Danny M Ball, Derek H Arnold, Kielan Yarrow
Humans might possess either a single (amodal) internal clock or multiple clocks for different sensory modalities. Sensitivity could be improved by the provision of multiple signals. Such improvements can be predicted quantitatively, assuming estimates are combined by summation, a process described as optimal when summation is weighted in accordance with the variance associated with each of the initially independent estimates. This possibility was assessed for visual and tactile information regarding temporal intervals...
February 23, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28230395/contextual-cueing-improves-attentional-guidance-even-when-guidance-is-supposedly-optimal
#9
Anthony M Harris, Roger W Remington
Visual search through previously encountered contexts typically produces reduced reaction times compared with search through novel contexts. This contextual cueing benefit is well established, but there is debate regarding its underlying mechanisms. Eye-tracking studies have consistently shown reduced number of fixations with repetition, supporting improvements in attentional guidance as the source of contextual cueing. However, contextual cueing benefits have been shown in conditions in which attentional guidance should already be optimal-namely, when attention is captured to the target location by an abrupt onset, or under pop-out conditions...
February 23, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28230394/the-onset-and-time-course-of-semantic-priming-during-rapid-recognition-of-visual-words
#10
Renske S Hoedemaker, Peter C Gordon
In 2 experiments, we assessed the effects of response latency and task-induced goals on the onset and time course of semantic priming during rapid processing of visual words as revealed by ocular response tasks. In Experiment 1 (ocular lexical decision task), participants performed a lexical decision task using eye movement responses on a sequence of 4 words. In Experiment 2, the same words were encoded for an episodic recognition memory task that did not require a metalinguistic judgment. For both tasks, survival analyses showed that the earliest observable effect (divergence point [DP]) of semantic priming on target-word reading times occurred at approximately 260 ms, and ex-Gaussian distribution fits revealed that the magnitude of the priming effect increased as a function of response time...
February 23, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28230385/auditory-cue-absence-as-a-conditioned-stimulus-for-delay-eyeblink-conditioning
#11
Matthew M Campolattaro, Sean W Savage, Olga Lipatova
The present experiment was designed to determine if the absence of an auditory cue (i.e., a "tone-off" cue) would be an effective conditioned stimulus (CS) for delay eyeblink conditioning and to test if the medial geniculate nucleus (MGN) is part of the sensory pathway for tone-off conditioning. Rats were given paired or unpaired delay eyeblink conditioning to examine if responding to a tone-off CS was due to an associative process. An inactivation technique was performed on a separate group of rats to determine if the MGN is needed to express tone-off conditioning...
February 23, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28230384/familiar-real-world-spatial-cues-provide-memory-benefits-in-older-and-younger-adults
#12
Jessica Robin, Morris Moscovitch
Episodic memory, future thinking, and memory for scenes have all been proposed to rely on the hippocampus, and evidence suggests that these all decline in healthy aging. Despite this age-related memory decline, studies examining the effects of context reinstatement on episodic memory have demonstrated that reinstating elements of the encoding context of an event leads to better memory retrieval in both younger and older adults. The current study was designed to test whether more familiar, real-world contexts, such as locations that participants visited often, would improve the detail richness and vividness of memory for scenes, autobiographical events, and imagination of future events in young and older adults...
February 23, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28230235/seeing-overweight-adults-as-babies-physical-cues-and-implications-for-stigmatization
#13
Anton J M Dijker, Rutger DeLuster, Nicolas Peeters, Nanne K de Vries
Human babies not only are reliable triggers of tender feelings and protective tendencies, they also happen to be exceptionally fat compared to the newborns of most other species. These two facts are used to formulate a hypothesis predicting that overweight males, due to their great physical resemblance to babies, not only are perceived as cute, but also are associated with negatively evaluated traits (e.g., immaturity, lack of willpower) that are saliently inconsistent with traits required for adults. In this study, a great many physical features of adult males varying widely in weight were measured and correlated with subjective judgements...
February 23, 2017: British Journal of Psychology
https://www.readbyqxmd.com/read/28229973/female-conspecifics-restore-rhythmic-singing-behaviour-in-arrhythmic-male-zebra-finches
#14
Neelu Anand Jha, Vinod Kumar
The present study investigated whether pairing with a conspecific female would restore rhythmicity in the singing behaviour of arrhythmic male songbirds. We recorded the singing and, as the circadian response indicator, monitored the activity-rest pattern in male zebra finches (Taeniopygia guttata) housed without or with a conspecific female under 12 h light: 12 h darkness (12L:12D) or constant bright light (LL bright). Both unpaired and paired birds exhibited a significant daily rhythm in the singing and activity behaviour, but paired birds, under 12L:12D, showed a ~2 h extension in the evening...
March 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/28229500/money-for-microbes-pathogen-avoidance-and-out-group-helping-behaviour
#15
Michael Laakasuo, Nils Köbis, Jussi Palomäki, Markus Jokela
Humans have evolved various adaptations against pathogens, including the physiological immune system. However, not all of these adaptations are physiological: the cognitive mechanisms whereby we avoid potential sources of pathogens-for example, disgust elicited by uncleanliness-can be considered as parts of a behavioural immune system (BIS). The mechanisms of BIS extend also to inter-group relations: Pathogen cues have been shown to increase xenophobia/ethnocentrism, as people prefer to keep their societal in-group norms unaltered and "clean...
February 23, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28229429/stimulus-response-incompatibility-eliminates-inhibitory-cueing-effects-with-saccadic-but-not-manual-responses
#16
Vivian Eng, Alfred Lim, Simon Kwon, Su Ren Gan, S Azrin Jamaluddin, Steve M J Janssen, Jason Satel
There are thought to be two forms of inhibition of return (IOR) depending on whether the oculomotor system is activated or suppressed. When saccades are allowed, output-based IOR is generated, whereas input-based IOR arises when saccades are prohibited. In a series of 4 experiments, we mixed or blocked compatible and incompatible trials with saccadic or manual responses to investigate whether cueing effects would follow the same pattern as those observed with more traditional peripheral onsets and central arrows...
February 22, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28229428/low-is-large-spatial-location-and-pitch-interact-in-voice-based-body-size-estimation
#17
Katarzyna Pisanski, Sari G E Isenstein, Kelyn J Montano, Jillian J M O'Connor, David R Feinberg
The binding of incongruent cues poses a challenge for multimodal perception. Indeed, although taller objects emit sounds from higher elevations, low-pitched sounds are perceptually mapped both to large size and to low elevation. In the present study, we examined how these incongruent vertical spatial cues (up is more) and pitch cues (low is large) to size interact, and whether similar biases influence size perception along the horizontal axis. In Experiment 1, we measured listeners' voice-based judgments of human body size using pitch-manipulated voices projected from a high versus a low, and a right versus a left, spatial location...
February 22, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28229407/assessment-of-energy-metabolic-changes-in-adipose-tissue-derived-stem-cells
#18
Ghazaleh Hajmousa, Martin C Harmsen
Adipose tissue-derived stem cells (ADSC) are promising candidates for therapeutic applications in cardiovascular regenerative medicine. By definition, the phenotype ADSCs, e.g., the ubiquitous secretion of growth factors, cytokines, and extracellular matrix components is not met in vivo, which renders ADSC a culture "artefact." The medium constituents therefore impact the efficacy of ADSC. Little attention has been paid to the energy source in medium, i.e., glucose, which feeds the cell's power plants: mitochondria...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28229330/the-involvement-of-the-myelin-associated-inhibitors-and-their-receptors-in-cns-plasticity-and-injury
#19
REVIEW
Anthony G Boghdadi, Leon Teo, James A Bourne
The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies have attempted to elucidate the biochemical and molecular mechanisms that inhibit neuronal repair with increasing evidence suggesting that several inhibitory factors and repulsive guidance cues active during development actually persist into adulthood and may be contributing to the inhibition of repair...
February 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28229088/glutathione-induces-gaba-release-through-p2x7r-activation-on-m%C3%A3-ller-glia
#20
Hércules Rezende Freitas, Ricardo A de Melo Reis
The retinal tissue of warm-blooded vertebrates performs surprisingly complex and accurate transduction of visual information. To achieve precision, a multilayered neuroglia structure is established throughout the embryonic development, and the presence of radial Müller (glial) cells ensure differentiation, growth and survival for the neuronal elements within retinal environment. It is assumed that Müller cells serve as a dynamic reservoir of progenitors, capable of expressing transcription factors, differentiating and proliferating as either neuronal or glial cells depending on extrinsic cues...
2017: Neurogenesis (Austin, Tex.)
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