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https://www.readbyqxmd.com/read/27903863/internalization-of-secreted-antigen-targeted-antibodies-by-the-neonatal-fc-receptor-for-precision-imaging-of-the-androgen-receptor-axis
#1
Daniel L J Thorek, Philip A Watson, Sang-Gyu Lee, Anson T Ku, Stylianos Bournazos, Katharina Braun, Kwanghee Kim, Kjell Sjöström, Michael G Doran, Urpo Lamminmäki, Elmer Santos, Darren Veach, Mesruh Turkekul, Emily Casey, Jason S Lewis, Diane S Abou, Marise R H van Voss, Peter T Scardino, Sven-Erik Strand, Mary L Alpaugh, Howard I Scher, Hans Lilja, Steven M Larson, David Ulmert
Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. AR-regulated human kallikrein-related peptidase 2 (free hK2) is a prostate tissue-specific antigen produced in prostate cancer and androgen-stimulated breast cancer cells...
November 30, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27902983/perinatal-asphyxia-and-erythropoietin-and-vegf-serial-serum-and-cerebrospinal-fluid-responses
#2
Deirdre U Sweetman, Chike Onwuneme, William R Watson, John F A Murphy, Eleanor J Molloy
BACKGROUND: Infants with neonatal encephalopathy (NE) of hypoxic-ischaemic origin are at risk of oxidative and ischaemia-reperfusion injury, which may induce abnormal inflammatory responses involving excessive cytokine production and release in serum and cerebrospinal fluid (CSF). Systemic inflammation is found in infants with NE, and we therefore were interested in cytokines associated with hypoxia, including vascular endothelial growth factor (VEGF) and erythropoietin (Epo). OBJECTIVE: To investigate the relationship between Epo, VEGF levels, brain injury and outcome in a group of term infants exposed to perinatal asphyxia (PA) compared to controls...
December 1, 2016: Neonatology
https://www.readbyqxmd.com/read/27902809/estimated-cost-of-sunburn-associated-visits-to-us-hospital-emergency-departments
#3
Gery P Guy, Zahava Berkowitz, Meg Watson
No abstract text is available yet for this article.
November 30, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27901302/factors-associated-with-intentional-and-unintentional-non-adherence-to-adjuvant-endocrine-therapy-following-breast-cancer
#4
J Brett, D Fenlon, M Boulton, N J Hulbert-Williams, F M Walter, P Donnelly, B Lavery, A Morgan, C Morris, E Watson
Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimal despite its known efficacy in reducing recurrence and mortality. This study aims to investigate factors associated with non-adherence and inform the development of interventions to support women and promote adherence. A questionnaire survey to measure level of adherence, side effects experienced, beliefs about medicine, support received and socio-demographic details was sent to 292 women 2-4 years post breast cancer diagnosis...
November 30, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27900161/past-and-projected-temporal-trends-in-arthroscopic-hip-surgery-in-england-between-2002-and-2013
#5
A J R Palmer, T T Malak, J Broomfield, J Holton, L Majkowski, G E R Thomas, A Taylor, A J Andrade, G Collins, K Watson, A J Carr, S Glyn-Jones
INTRODUCTION: Hip arthroscopy is increasingly adopted for the treatment of intra-articular and extra-articular pathologies. Studies from USA demonstrate a 365% increase in the number of procedures performed between 2004 and 2009 and 250% increase between 2007 and 2011. There is limited evidence of long-term efficacy for this procedure and hip arthroscopy is not universally funded across England. The aim of this study is to describe temporal trends in the adoption of hip arthroscopy in England between 2002 and 2013 and to forecast trends for the next 10 years...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27899327/novel-application-of-species-richness-estimators-to-predict-the-host-range-of-parasites
#6
David M Watson, Kirsty V Milner, Andrea Leigh
Host range is a critical life history trait of parasites, influencing prevalence, virulence and ultimately determining their distributional extent. Current approaches to measure host range are sensitive to sampling effort, the number of known hosts increasing with more records. Here, we develop a novel application of results-based stopping rules to determine how many hosts should be sampled to yield stable estimates of the number of primary hosts within regions, then use species richness estimation to predict host ranges of parasites across their distributional ranges...
November 26, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27899072/appropriateness-of-antibiotic-management-of-uncomplicated-skin-and-soft-tissue-infections-in-hospitalized-adult-patients
#7
Thomas L Walsh, Lynn Chan, Chelsea I Konopka, Michael J Burkitt, Matthew A Moffa, Derek N Bremmer, Monika A Murillo, Courtney Watson, Noreen H Chan-Tompkins
BACKGROUND: Skin and soft tissue infections (SSTIs) are a leading cause for hospitalizations in the United States. Few studies have addressed the appropriateness of antibiotic therapy in the management of SSTIs without complicating factors. We aimed to determine the appropriateness of antibiotic treatment duration for hospitalized adult patients with uncomplicated SSTIs. METHODS: This was a retrospective analysis performed at two academic medical centers in Pittsburgh, Pennsylvania on patients aged 18 years and older with primary ICD-9 code for SSTIs admitted August 1st, 2014-March 31st, 2015...
November 29, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27898216/characterization-of-prostacyclin-associated-leg-pain-in-patients-with-pulmonary-arterial-hypertension
#8
Gabriel L Pagani-Estévez, Keith M Swetz, Michael D McGoon, Robert P Frantz, Susan K Tointon, Ann M Karnyski, Louise A Durst, James C Watson
RATIONALE: Prostacyclin-associated leg pain is a potentially debilitating adverse effect of prostacyclin therapy for patients with pulmonary arterial hypertension (PAH). However, to our knowledge, this entity has not been systematically studied. OBJECTIVE: To characterize the clinical features and metabolic risk factors for prostacyclinassociated leg pain. METHODS: At one academic medical center we assembled and analyzed a case series of patients with PAH and prostacyclin-associated leg pain...
November 29, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27897967/an-observational-study-of-donor-ex-vivo-lung-perfusion-in-uk-lung-transplantation-develop-uk
#9
Andrew Fisher, Anders Andreasson, Alexandros Chrysos, Joanne Lally, Chrysovalanto Mamasoula, Catherine Exley, Jennifer Wilkinson, Jessica Qian, Gillian Watson, Oli Lewington, Thomas Chadwick, Elaine McColl, Mark Pearce, Kay Mann, Nicola McMeekin, Luke Vale, Steven Tsui, Nizar Yonan, Andre Simon, Nandor Marczin, Jorge Mascaro, John Dark
BACKGROUND: Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. OBJECTIVE: The objective of the Donor Ex Vivo Lung Perfusion in UK lung transplantation study was to evaluate the clinical effectiveness and cost-effectiveness of EVLP in increasing UK lung transplant activity. DESIGN: A multicentre, unblinded, non-randomised, non-inferiority observational study to compare transplant outcomes between EVLP-assessed and standard donor lungs...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27895832/clostridium-difficile-a-healthcare-associated-infection-of-unknown-significance-in-adults-in-sub-saharan-africa
#10
REVIEW
Alexander J Keeley, Nicholas J Beeching, Katharine E Stott, Paul Roberts, Alastair J Watson, Michael Bj Beadsworth
BACKGROUND: Clostridium difficile infection (CDI) causes a high burden of disease in high-resource healthcare systems, with significant morbidity, mortality, and financial implications. CDI is a healthcare-associated infection for which the primary risk factor is antibiotic usage, and it is the leading cause of bacterial diarrhoea in HIV-infected patients in the United States. Little is known about the disease burden of CDI in sub-Saharan Africa, where HIV and healthcare-associated infections are more prevalent and antibiotic usage is less restricted...
June 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27894903/structural-basis-of-accurate-replication-beyond-a-bulky-major-benzo-a-pyrene-adduct-by-human-dna-polymerase-kappa
#11
Vikash Jha, Hong Ling
Human Y-family DNA polymerase kappa (polκ) is specialized to bypass bulky lesions in DNA in an error-free way, thus protecting cells from carcinogenic bulky DNA adducts. Benzo[a]pyrene (BP) is one of the most ubiquitous polycyclic aromatic hydrocarbons and an environmental carcinogen. BP covalently modifies DNA and generates mutagenic, bulky adducts. The major BP adduct formed in cells is 10S (+)-trans-anti-BP-N(2)-dG adduct (BP-dG), which is associated with cancer. The molecular mechanism of how polκ replicates BP-dG accurately is not clear...
November 19, 2016: DNA Repair
https://www.readbyqxmd.com/read/27893639/surgical-rescue-the-next-pillar-of-acute-care-surgery
#12
Matthew E Kutcher, Jason L Sperry, Matthew R Rosengart, Deepika Mohan, Marcus K Hoffman, Matthew D Neal, Louis H Alarcon, Gregory A Watson, Juan Carlos Puyana, Graciela M Bauzá, Vaishali D Schuchert, Anisleidy Fombona, Tianhua Zhou, Samuel Zolin, Robert D Becher, Timothy R Billiar, Raquel M Forsythe, Brian S Zuckerbraun, Andrew B Peitzman
BACKGROUND: The evolving field of Acute Care Surgery (ACS) traditionally includes trauma, emergency general surgery, and critical care. However, the critical role of ACS in the rescue of patients with a surgical complication has not been explored. We here describe the role of 'surgical rescue' in the practice of Acute Care Surgery (ACS). METHODS: A prospective, electronic medical record-based ACS registry spanning January 2013 to May 2014 at a large urban academic medical center was screened by ICD-9 codes for acute surgical complications of an operative or interventional procedure...
November 23, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27893040/association-of-a-dedicated-post-hospital-discharge-follow-up-visit-and-30-day-readmission-risk-in-a-medicare-advantage-population
#13
Ernest Shen, Sandra Y Koyama, Dan N Huynh, Heather L Watson, Brian Mittman, Michael H Kanter, Huong Q Nguyen
No abstract text is available yet for this article.
November 21, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27892617/does-education-in-italy-produce-nurses-fit-for%C3%A2-future-healthcare-needs
#14
Roger Watson, Giuseppe Aleo, Loredana Sasso, Annamaria Bagnasco, Gianluca Catania, Milko Zanini
No abstract text is available yet for this article.
December 2016: International Nursing Review
https://www.readbyqxmd.com/read/27889953/ecology-under-lake-ice
#15
REVIEW
Stephanie E Hampton, Aaron W E Galloway, Stephen M Powers, Ted Ozersky, Kara H Woo, Ryan D Batt, Stephanie G Labou, Catherine M O'Reilly, Sapna Sharma, Noah R Lottig, Emily H Stanley, Rebecca L North, Jason D Stockwell, Rita Adrian, Gesa A Weyhenmeyer, Lauri Arvola, Helen M Baulch, Isabella Bertani, Larry L Bowman, Cayelan C Carey, Jordi Catalan, William Colom-Montero, Leah M Domine, Marisol Felip, Ignacio Granados, Corinna Gries, Hans-Peter Grossart, Juta Haberman, Marina Haldna, Brian Hayden, Scott N Higgins, Jeff C Jolley, Kimmo K Kahilainen, Enn Kaup, Michael J Kehoe, Sally MacIntyre, Anson W Mackay, Heather L Mariash, Robert M McKay, Brigitte Nixdorf, Peeter Nõges, Tiina Nõges, Michelle Palmer, Don C Pierson, David M Post, Matthew J Pruett, Milla Rautio, Jordan S Read, Sarah L Roberts, Jacqueline Rücker, Steven Sadro, Eugene A Silow, Derek E Smith, Robert W Sterner, George E A Swann, Maxim A Timofeyev, Manuel Toro, Michael R Twiss, Richard J Vogt, Susan B Watson, Erika J Whiteford, Marguerite A Xenopoulos
Winter conditions are rapidly changing in temperate ecosystems, particularly for those that experience periods of snow and ice cover. Relatively little is known of winter ecology in these systems, due to a historical research focus on summer 'growing seasons'. We executed the first global quantitative synthesis on under-ice lake ecology, including 36 abiotic and biotic variables from 42 research groups and 101 lakes, examining seasonal differences and connections as well as how seasonal differences vary with geophysical factors...
November 27, 2016: Ecology Letters
https://www.readbyqxmd.com/read/27888895/treating-scars-in-the-auricle-region
#16
REVIEW
Deborah Watson, Bharat Panuganti
This article provides a review of the surgical and nonsurgical options available to manage a variety of auricular scars. The basics of wound healing are discussed in addition to the etiology of keloids and the cauliflower ear. Many auricular scars can be revised with scar excision techniques, but separate discussions for the treatment of keloids and the cauliflower ear are provided. The management plan for auricular scarring requires appropriate patient counseling regarding the risk of recurrence in keloids, regrowth of scar tissue in cauliflower ears, scar hypertrophy at the line of closure, widening of the scar, and persisting ear contour deformities...
February 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/27888090/rationale-and-design-of-mi-care-the-mile-square-colorectal-cancer-screening-awareness-and-referral-and-education-project
#17
Joanna Buscemi, Yazmin San Miguel, Lisa Tussing-Humphreys, Elizabeth A Watts, Marian L Fitzgibbon, Karriem Watson, Robert A Winn, Kameron L Matthews, Yamile Molina
Although colorectal cancer (CRC) is largely preventable through identification of pre-cancerous polyps through various screening modalities, morbidity and mortality rates remain a challenge, especially in African-American, Latino, low-income and uninsured/underinsured patients. Barriers to screening include cost, access to health care facilities, lack of recommendation to screen, and psychosocial factors such as embarrassment, fear of the test, anxiety about testing preparation and fear of a cancer diagnosis...
November 22, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27886470/stability-of-high-density-two-dimensional-excitons-against-a-mott-transition-in-high-magnetic-fields-probed-by-coherent-terahertz-spectroscopy
#18
Qi Zhang, Yongrui Wang, Weilu Gao, Zhongqu Long, John D Watson, Michael J Manfra, Alexey Belyanin, Junichiro Kono
We have performed time-resolved terahertz absorption measurements on photoexcited electron-hole pairs in undoped GaAs quantum wells in magnetic fields. We probed both unbound- and bound-carrier responses via cyclotron resonance and intraexciton resonance, respectively. The stability of excitons, monitored as the pair density was systematically increased, was found to dramatically increase with increasing magnetic field. Specifically, the 1s-2p_{-} intraexciton transition at 9 T persisted up to the highest density, whereas the 1s-2p feature at 0 T was quickly replaced by a free-carrier Drude response...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27884946/analysis-of-the-caenorhabditis-elegans-innate-immune-response-to-coxiella-burnetii
#19
James M Battisti, Lance A Watson, Myo T Naung, Adam M Drobish, Ekaterina Voronina, Michael F Minnick
The nematode Caenorhabditis elegans is well established as a system for characterization and discovery of molecular mechanisms mediating microbe-specific inducible innate immune responses to human pathogens. Coxiella burnetii is an obligate intracellular bacterium that causes a flu-like syndrome in humans (Q fever), as well as abortions in domesticated livestock, worldwide. Initially, when wild type C. elegans (N2 strain) was exposed to mCherry-expressing C. burnetii (CCB) a number of overt pathological manifestations resulted, including intestinal distension, deformed anal region and a decreased lifespan...
November 24, 2016: Innate Immunity
https://www.readbyqxmd.com/read/27883997/cbt4bn-a-randomized-controlled-trial-of-online-chat-and-face-to-face-group-therapy-for-bulimia-nervosa
#20
Stephanie C Zerwas, Hunna J Watson, Sara M Hofmeier, Michele D Levine, Robert M Hamer, Ross D Crosby, Cristin D Runfola, Christine M Peat, Jennifer R Shapiro, Benjamin Zimmer, Markus Moessner, Hans Kordy, Marsha D Marcus, Cynthia M Bulik
OBJECTIVE: Although cognitive-behavioral therapy (CBT) represents the first-line evidence-based psychotherapy for bulimia nervosa (BN), most individuals seeking treatment do not have access to this specialized intervention. We compared an Internet-based manualized version of CBT group therapy for BN conducted via a therapeutic chat group (CBT4BN) to the same treatment conducted via a traditional face-to-face group therapy (CBTF2F). METHOD: In a two-site, randomized, controlled noninferiority trial, we tested the hypothesis that CBT4BN would not be inferior to CBTF2F...
November 25, 2016: Psychotherapy and Psychosomatics
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