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https://www.readbyqxmd.com/read/28319322/an-analysis-of-the-survival-outcomes-of-simultaneous-pancreas-and-kidney-transplantation-compared-to-live-donor-kidney-transplantation-in-patients-with-type-1-diabetes-a-uk-transplant-registry-study
#1
Adam D Barlow, Kourosh Saeb-Parsy, Christopher J E Watson
BACKGROUND: Transplant options for patients with type 1 diabetes and end-stage renal disease (ESRD) include deceased donor kidney, live donor kidney (LDK) and simultaneous pancreas-kidney (SPK) transplantation. The aim of this study was to compare outcomes between LDK and SPK for patients with type 1 diabetes and ESRD in the UK. METHODS: Data on all SPK (n=1739) and LDK (n=385) transplants performed between January 2001 and December 2014 were obtained from the UK Transplant Registry...
March 20, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28317975/exposing-the-g-quadruplex-to-electric-fields-the-role-played-by-telomeres-in-the-propagation-of-dna-errors
#2
José Pedro Cerón-Carrasco, Denis Jacquemin
To protect their core machinery from the attack of exogenous agents, cells locate DNA in their nucleus. Nevertheless, some reactive chemical species and physical agents might reach DNA and alter its natural double helix structure. For instance, pulsed electric fields can be used to selectively rewrite the stored genetic information. However, for such modification to be effective, one needs, as a prerequisite, that the replication mechanism is not stopped by the field, so that the changes propagate over the following generations...
March 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28317015/evaluation-of-the-2015-aga-guidelines-on-pancreatic-cystic-neoplasms-in-a-large-surgically-confirmed-multicenter-cohort
#3
Phillip S Ge, V Raman Muthusamy, Srinivas Gaddam, Diana-Marie Jaiyeola, Stephen Kim, Alireza Sedarat, Timothy R Donahue, Lindsay Hosford, Robert H Wilson, David P Grande, Rajesh N Keswani, Vladimir M Kushnir, Daniel Mullady, Steven A Edmundowicz, Dayna S Early, Srinadh Komanduri, Sachin Wani, Rabindra R Watson
Background and study aims The American Gastroenterological Association (AGA) recently published guidelines for the management of asymptomatic pancreatic cystic neoplasms (PCNs). We aimed to evaluate the diagnostic characteristics of the AGA guidelines in appropriately recommending surgery for malignant PCNs. Patients and methods A retrospective multicenter study was performed of patients who underwent endoscopic ultrasound (EUS) for evaluation of PCNs who ultimately underwent surgical resection from 2004 - 2014...
March 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28316304/postoperative-central-anticholinergic-syndrome-is-it-really-that-rare
#4
Celia Y Quang, Scott G Blair, Robert Watson, Sidney B Brevard, Jon D Simmons, Marcus C B Tan
No abstract text is available yet for this article.
March 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28315927/hla-dr-expression-in-tumor-epithelium-is-an-independent-prognostic-indicator-in-esophageal-adenocarcinoma-patients
#5
Margaret R Dunne, Adriana J Michielsen, Katie E O'Sullivan, Mary Clare Cathcart, Ronan Feighery, Brendan Doyle, Jenny A Watson, Naoimh J O'Farrell, Narayanasamy Ravi, Elaine Kay, John V Reynolds, Elizabeth J Ryan, Jacintha O'Sullivan
Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis, and incidence is increasing rapidly in the Western world. Measurement of immune markers has been shown to have prognostic significance in a growing number of cancers, but whether this is true for EAC has yet to be evaluated. This study aimed to characterize HLA-DR expression in the esophagus across the inflammation to cancer progression sequence and to assess the prognostic significance of HLA-DR expression in EAC. Tissue microarrays (TMA) were constructed from esophageal tissue taken from patients at different stages in the cancer progression sequence; normal, esophagitis, Barrett's esophagus (BE), low- and high-grade dysplasia (LGD, HGD) and EAC...
March 18, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28315771/evidence-for-two-populations-of-hair-bundles-in-the-sea-anemone-nematostella-vectensis
#6
Shelcie S Menard, Glen M Watson
Cytochalasin D (CD) was employed to disrupt F-actin within stereocilia of anemone hair bundles. CD treatment decreases the abundance of hair bundles (by 85%) while significantly impairing predation. The remaining hair bundles are 'CD-resistant.' Surprisingly, the morphology and F-actin content of resistant hair bundles are comparable to those of untreated controls. However, the resistant hair bundles fail to respond normally to the N-acetylated sugar, NANA, by elongating. Instead, they remain at resting length...
March 15, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28315573/mortality-length-of-stay-and-cost-implications-of-procedural-bleeding-after-percutaneous-interventions-using-large-bore-catheters
#7
Björn Redfors, Brendan M Watson, Thomas McAndrew, Emilie Palisaitis, Dominic P Francese, Mehdi Razavi, Jordan Safirstein, Roxana Mehran, Ajay J Kirtane, Philippe Généreux
Importance: Bleeding complications after percutaneous transcatheter interventions that used large-bore catheters are frequent and associated with high mortality and morbidity. Objective: To describe the incidence of bleeding complications among patients undergoing contemporary endovascular interventions involving large-bore catheters and its association with in-hospital mortality, length of stay, and health care cost. Design, Setting, and Participants: This retrospective cohort study analyzed all 17 672 patients from the Healthcare Cost and Utilization Project's National Inpatient Sample database who were recorded as having undergone a transcatheter aortic valve replacement (n = 3223), an endovascular aneurysm repair (n = 12 633), or a percutaneous left ventricular assist device implant (n = 1816) between January 1, 2012, and December 31, 2013...
March 18, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28315414/the-dynamics-of-hcv-specific-antibody-responses-in-hiv-hcv-patients-on-long-term-antiretroviral-therapy
#8
Silvia Lee, Alfred Laiman, Martyn A French, James Flexman, Mark W Watson, Patricia Price
Antibody responses have not been fully characterised in chronically HIV/HCV patients receiving antiretroviral therapy (ART). Seventeen HIV/HCV patients receiving ART were followed for a median (range) interval of 597 (186-766) weeks. Prior to ART, HIV/HCV patients had lower levels of antibodies reactive with HCV core and JFH-1, and lower genotype cross-reactive neutralising antibodies (nAb) titres, than HCV patients. Levels of JFH-1 reactive antibody increased on ART, irrespective of CD4(+) T-cell counts or changes in serum ALT levels...
March 14, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28314075/expert-views-on-biological-threat-characterization-for-the-u-s-government-a-delphi-study
#9
Crystal R Watson, Matthew C Watson, Gary Ackerman, Gigi Kwik Gronvall
Biological threat characterization (BTC) involves laboratory research conducted for the purpose of biological defense. BTC research is important for improving biological risk assessment and informing resource prioritization. However, there are also risks involved in BTC work, including potential for escape from the laboratory or the misuse of research results. Using a modified Delphi study to gather opinions from U.S. experts in biosecurity and biodefense, this analysis explores what principles and safeguards can maximize the benefits of BTC research and ensure that it is conducted safely and securely...
March 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28306267/multiband-one-dimensional-electronic-structure-and-spectroscopic-signature-of-tomonaga-luttinger-liquid-behavior-in-k_-2-cr_-3-as_-3
#10
M D Watson, Y Feng, C W Nicholson, C Monney, J M Riley, H Iwasawa, K Refson, V Sacksteder, D T Adroja, J Zhao, M Hoesch
We present angle-resolved photoemission spectroscopy measurements of the quasi-one-dimensional superconductor K_{2}Cr_{3}As_{3}. We find that the Fermi surface contains two Fermi surface sheets, with linearly dispersing bands not displaying any significant band renormalizations. The one-dimensional band dispersions display a suppression of spectral intensity approaching the Fermi level according to a linear power law, over an energy range of ∼200  meV. This is interpreted as a signature of Tomonoga-Luttinger liquid physics, which provides a new perspective on the possibly unconventional superconductivity in this family of compounds...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28302674/urine-culture-follow-up-and-antimicrobial-stewardship-in-a-pediatric-urgent-care-network
#11
Dipanwita Saha, Jimisha Patel, Don Buckingham, David Thornton, Terry Barber, Joshua R Watson
BACKGROUND AND OBJECTIVES: Empiric antibiotic therapy for presumed urinary tract infection (UTI) leads to unnecessary antibiotic exposure in many children whose urine culture results fail to confirm the diagnosis. The objective of this quality improvement study was to improve follow-up management of negative urine culture results in the off-campus urgent care network of Nationwide Children's Hospital to reduce inappropriate antibiotic exposure in children. METHODS: A multidisciplinary task force developed and implemented a protocol for routine nurse and clinician follow-up of urine culture results, discontinuation of unnecessary antibiotics, and documentation in the electronic medical record...
March 16, 2017: Pediatrics
https://www.readbyqxmd.com/read/28301195/mode-of-administration-effects-in-psychopathology-assessment-analyses-of-gender-age-and-education-differences-in-self-rated-versus-interview-based-depression
#12
Holly F Levin-Aspenson, David Watson
Respondents may answer sensitive questions differently depending on the mode of assessment (e.g., questionnaire, interview). The possibility of differences in these mode effects across groups is an important assessment consideration given the implications for test-score validity and bias. Although differences in mode effects are highly relevant to issues in clinical assessment, research is limited and generally fails to make use of psychometrically sound methods. The present research argues for greater attention to demographic differences in mode effects with regard to the assessment of psychopathology...
March 16, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28299467/cardiomyocyte-ogt-limits-ventricular-dysfunction-in-mice-following-pressure-overload-without-affecting-hypertrophy
#13
Sujith Dassanayaka, Robert E Brainard, Lewis J Watson, Bethany W Long, Kenneth R Brittian, Angelica M DeMartino, Allison L Aird, Anna M Gumpert, Timothy N Audam, Peter J Kilfoil, Senthilkumar Muthusamy, Tariq Hamid, Sumanth D Prabhu, Steven P Jones
The myocardial response to pressure overload involves coordination of multiple transcriptional, posttranscriptional, and metabolic cues. The previous studies show that one such metabolic cue, O-GlcNAc, is elevated in the pressure-overloaded heart, and the increase in O-GlcNAcylation is required for cardiomyocyte hypertrophy in vitro. Yet, it is not clear whether and how O-GlcNAcylation participates in the hypertrophic response in vivo. Here, we addressed this question using patient samples and a preclinical model of heart failure...
May 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28297170/meibomian-gland-disease-and-the-microbiotome-is-it-time-for-ocular-probiotics
#14
EDITORIAL
Stephanie Watson
No abstract text is available yet for this article.
March 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28297147/compound-heterozygosity-of-dominant-and-recessive-col7a-alleles-in-a-severely-affected-patient-with-a-family-history-of-dystrophic-epidermolysis-bullosa-clinical-findings-genetic-testing-and-treatment-implications
#15
Kendra D Watson, Jennifer J Schoch, Geoffrey J Beek, Jennifer L Hand
An 8-year-old girl born to a family with more than three generations of dominant dystrophic epidermolysis bullosa (DDEB) presented with life-threatening confluent skin erosions, mitten hand deformity, and failure to thrive. Reassessment of her family history and genetic testing showed compound heterozygous COL7A mutations, one inherited from her DDEB-affected mother and one from her unaffected, healthy father. This family illustrates the risk of unexpected, severe, autosomal recessive epidermolysis bullosa (EB) in a family with milder, multigenerational autosomal dominant EB...
March 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28296451/proactive-vendor-management-for-healthcare-technology
#16
Samantha Jacques, Aimee Watson
No abstract text is available yet for this article.
March 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28295461/what-do-uk-medical-students-value-most-in-their-careers-a-discrete-choice-experiment
#17
Jennifer A Cleland, Peter Johnston, Verity Watson, Nicolas Krucien, Diane Skåtun
CONTEXT: Many individual- and job-related factors are known to influence medical careers decision making. Previous research has extensively studied medical trainees' (residents') and students' views of the factors that are important. However, how trainees and students trade off these factors at times of important careers-related decision making is under-researched. Information about trade-offs is crucial to the development of effective policies to enhance the recruitment and retention of junior doctors...
March 14, 2017: Medical Education
https://www.readbyqxmd.com/read/28295409/working-memory-capacity-and-task-goals-modulate-error-related-erps
#18
James R Coleman, Jason M Watson, David L Strayer
The present study investigated individual differences in information processing following errant behavior. Participants were initially classified as high or as low working memory capacity using the Operation Span Task. In a subsequent session, they then performed a high congruency version of the flanker task under both speed and accuracy stress. We recorded ERPs and behavioral measures of accuracy and response time in the flanker task with a primary focus on processing following an error. The error-related negativity was larger for the high working memory capacity group than for the low working memory capacity group...
March 15, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28291826/endothelial-progenitor-cells-in-chronic-obstructive-pulmonary-disease-and-emphysema
#19
Margaret F Doyle, Russell P Tracy, Megha A Parikh, Eric A Hoffman, Daichi Shimbo, John H M Austin, Benjamin M Smith, Katja Hueper, Jens Vogel-Claussen, Joao Lima, Antoinette Gomes, Karol Watson, Steven Kawut, R Graham Barr
Endothelial injury is implicated in the pathogenesis of COPD and emphysema; however the role of endothelial progenitor cells (EPCs), a marker of endothelial cell repair, and circulating endothelial cells (CECs), a marker of endothelial cell injury, in COPD and its subphenotypes is unresolved. We hypothesized that endothelial progenitor cell populations would be decreased in COPD and emphysema and that circulating endothelial cells would be increased. Associations with other subphenotypes were examined. The Multi-Ethnic Study of Atherosclerosis COPD Study recruited smokers with COPD and controls age 50-79 years without clinical cardiovascular disease...
2017: PloS One
https://www.readbyqxmd.com/read/28291157/deceased-organ-donors-with-a-history-of-increased-risk-behavior-for-the-transmission-of-blood-borne-viral-infection-the-uk-experience
#20
Patrick B Trotter, Dominic M Summers, Matthew Robb, William Hulme, Ines Ushiro-Lumb, Christopher J E Watson, James Neuberger, Andrew J Bradley
BACKGROUND: Deceased organ donors are routinely screened for behaviors that increase the risk of transmissible blood borne viral (BBV) infection, but the impact of this information on organ donation and transplant outcome is not well documented. Our aim was to establish the impact of such behavior on organ donation and utilization, as well transplant recipient outcomes. METHODS: We identified all UK deceased organ donors from 2003-2015 with a disclosed history of increased risk behavior (IRB) including intravenous drug use (IVDU), imprisonment and increased risk sexual behavior...
March 13, 2017: Transplantation
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