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REVIEW
Florencia Rosetti, Iris K Madera-Salcedo, José C Crispín
Systemic lupus erythematosus (SLE) and other autoimmune diseases are thought to develop in genetically predisposed individuals when triggered by environmental factors. This paradigm does not fully explain disease development, as it fails to consider the delay between birth and disease expression. In this review, we discuss observations described in T cells from patients with SLE that are not related to hereditary factors and have therefore been considered secondary to the disease process itself. Here, we contextualize some of those observations and argue that they may represent a pathogenic layer between genetic factors and disease development...
April 18, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#22
REVIEW
Iris Parés-Salomón, Anna M Señé-Mir, Fernando Martín-Bozas, Bette Loef, Alan Coffey, Kieran P Dowd, Guillem Jabardo-Camprubí, Karin I Proper, Anna Puig-Ribera, Judit Bort-Roig
BACKGROUND: Digital interventions are potential tools for reducing and limiting occupational sedentary behaviour (SB) in sedentary desk-based jobs. Given the harmful effects of sitting too much and sitting for too long while working, the aim of this systematic review and meta-analysis was to examine the effectiveness of workplace interventions, that incorporated digital elements, to reduce the time spent in SB in office workers. METHODS: Randomised control trials that evaluated the implementation of workplace interventions that incorporated digital elements for breaking and limiting SB among desk-based jobs were identified by literature searches in six electronic databases (PubMed, Web of Science, Scopus, CINAHL, PsycINFO and PEDro) published up to 2023...
April 19, 2024: International Journal of Behavioral Nutrition and Physical Activity
#23
JOURNAL ARTICLE
Lorenzo Carosini, Virginia Oddi, Francesco Giorgino, Lena M Hansen, Benoit Seron, Simone Piacentini, Tobias Guggemos, Iris Agresti, Juan C Loredo, Philip Walther
The interference of nonclassical states of light enables quantum-enhanced applications reaching from metrology to computation. Most commonly, the polarization or spatial location of single photons are used as addressable degrees of freedom for turning these applications into praxis. However, the scale-up for the processing of a large number of photons of these architectures is very resource-demanding due to the rapidly increasing number of components, such as optical elements, photon sources, and detectors...
April 19, 2024: Science Advances
#24
JOURNAL ARTICLE
Nitza Heiman Newman, Idan Farber, Eitan Lunenfeld, Atif Zeadna, Iris Har Vardi, Zaki Assi
Infertility, affecting one in six couples, is often related to the male partner's congenital and/or environmental conditions or complications postsurgery. This retrospective study examines the link between orchiopexy for undescended testicles (UDT) and testicular torsion (TT) in childhood and adult fertility as assessed through sperm analysis. The study involved the analysis of semen samples from 7743 patients collected at Soroka University Medical Center (Beer Sheva, Israel) between January 2009 and December 2017...
April 19, 2024: Asian Journal of Andrology
#25
JOURNAL ARTICLE
Cornelius Deuschl, Lukas Goertz, Christoph Kabbasch, Martin Köhrmann, Christoph Kleinschnitz, Ansgar Berlis, Christoph Johannes Maurer, Iris Mühlen, Bernd Kallmünzer, Matthias Gawlitza, Daniel P O Kaiser, Joachim Klisch, Donald Lobsien, Daniel Behme, Maximilian Thormann, Fabian Flottmann, Laurens Winkelmeier, Elke Ruth Gizewski, Lukas Mayer-Suess, Markus Holtmannspoetter, Christoph Moenninghoff, Martin Schlunz-Hendann, Dominik Grieb, Christophe T Arendt, Ferdinand O Bohmann, Jens Altenbernd, Yan Li, Ulrich Sure, Ruben Mühl-Benninghaus, Thomas Rodt, Kai Kallenberg, Alexandru Durutya, Mohamed Elsharkawy, Christian-Paul Stracke, Mathias Gerhard Schumann, Alexander Bock, Omid Nikoubashman, Martin Wiesmann, Hans Henkes, Sebastian Dolff, Aydin Demircioglu, Michael Forsting, Hanna Styczen
BACKGROUND: Data on impact of COVID-19 vaccination and outcomes of patients with COVID-19 and acute ischemic stroke undergoing mechanical thrombectomy are scarce. Addressing this subject, we report our multicenter experience. METHODS AND RESULTS: This was a retrospective analysis of patients with COVID-19 and known vaccination status treated with mechanical thrombectomy for acute ischemic stroke at 20 tertiary care centers between January 2020 and January 2023. Baseline demographics, angiographic outcome, and clinical outcome evaluated by the modified Rankin Scale score at discharge were noted...
April 19, 2024: Journal of the American Heart Association
#26
JOURNAL ARTICLE
Michele Massimo Gulizia, Fabio Maria Turazza, Pietro Ameri, Marco Alings, Ronan Collins, Leonardo De Luca, Marcello Di Nisio, Donata Lucci, Domenico Gabrielli, Stefan Janssens, Iris Parrini, Fausto J Pinto, Jose Luis Zamorano, Furio Colivicchi
BACKGROUND: Cancer is an important condition associated with the development of atrial fibrillation (AF). The objectives of the BLITZ-AF Cancer study were to collect real-life information on the clinical profile and use of antithrombotic drugs in patients with AF and cancer to improve clinical management, as well as the evaluation of the association between different antithrombotic treatments (or their absence) and the main clinical events. METHODS: European multinational, multicenter, prospective, non-interventional study conducted in patients with AF (electrocardiographically confirmed) and cancer occurring within 3 years...
May 2024: Giornale Italiano di Cardiologia
#27
JOURNAL ARTICLE
Antônio Bonfada Collares Machado, Katia Irie Teruya, Rogério Friedman, Gibson Juliano Weydmann, Eduardo Remor, Lisiane Bizarro
Objective: The current cross-sectional study aimed to examine the association between childhood trauma, impulsivity, binge eating symptoms, and body mass index (BMI) in a sample of males and females. We also aimed to investigate the indirect association of childhood trauma with binge eating through impulsivity while controlling for BMI. Method: Participants were 410 young adults (mean age = 20.9 years, range 18-24; female = 73.9%) who completed online measures of childhood trauma, impulsivity, binge eating symptoms, and self-reported height and weight...
April 18, 2024: Journal of Child and Adolescent Mental Health
#28
REVIEW
Huy Q Ta, Maniselvan Kuppusamy, Swapnil K Sonkusare, Mark E Roeser, Victor E Laubach
The success of lung transplantation is limited by the high rate of primary graft dysfunction due to ischemia-reperfusion injury (IRI). Lung IRI is characterized by a robust inflammatory response, lung dysfunction, endothelial barrier disruption, oxidative stress, vascular permeability, edema, and neutrophil infiltration. These events are dependent on the health of the endothelium, which is a primary target of IRI that results in pulmonary endothelial barrier dysfunction. Over the past 10 years, research has focused more on the endothelium, which is beginning to unravel the multi-factorial pathogenesis and immunologic mechanisms underlying IRI...
April 18, 2024: Respiratory Research
#29
JOURNAL ARTICLE
Kim Robin van Daalen, Nanine Wyma, Johanna Schauer-Berg, Iris M Blom, Juliette Mattijsen, Razan Othman, Mohamed Eissa, Robbie M Parks, Arthur Wyns, Ahmed Taha Aboushady, Muha Hassan, Tarek Ezzine, Salman Khan, Menna-Allah Elsayed Zayed, Sarah Neggazi, Lujain Alqodmani, Rachel Lowe
No abstract text is available yet for this article.
April 18, 2024: BMJ Global Health
#30
JOURNAL ARTICLE
Wouter H Zwart, Sofieke J D Temmink, Geke A P Hospers, Corrie A M Marijnen, Hein Putter, Iris D Nagtegaal, Lennart Blomqvist, Elma Meershoek-Klein Kranenbarg, Annet G H Roodvoets, Anna Martling, Cornelis J H van de Velde, Bengt Glimelius, Koen C M J Peeters, Boudewijn van Etten, Per J Nilsson
BACKGROUND: A pathological complete response (pCR) following chemoradiation (CRT) or short-course radiotherapy (scRT) leads to a favourable prognosis in patients with rectal cancer. Total neo-adjuvant therapy (TNT) doubles the pCR rate, but it is unknown whether oncological outcomes remain favourable and whether the same characteristics are associated with pCR as after CRT. METHODS: Comparison between patients with pCR in the RAPIDO trial in the experimental [EXP] (scRT, chemotherapy, surgery, as TNT) and standard-of-care treatment [STD] (CRT, surgery, postoperative chemotherapy depending on hospital policy) groups...
April 7, 2024: European Journal of Cancer
#31
JOURNAL ARTICLE
Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner.
Aikaterini Karagianni, Anastasia Iris Karkempetzaki, Daniel J Brooks, Shinobu Matsuura, Vrinda Dambal, Philip C Trackman, Katya Ravid
Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.
April 18, 2024: Blood
#32
JOURNAL ARTICLE
Sibel Nayman, Isabelle Florence Schricker, Iris Reinhard, Janina Kim Dreer, Annika Sophie Richter, Christine Kuehner
Premenstrual dysphoric disorder (PMDD) is characterized by a cyclical symptom course. Previous research provides limited findings on possible menstrual-cycle-related psychological and psychoendocrinological processes in PMDD. By using ambulatory assessment (AA), we aimed to compare mood and cortisol cyclicity in individuals with PMDD and healthy controls (HC), and to assess effects of habitual and momentary repetitive negative thinking (RNT) and present moment awareness (PMA) on mood and cortisol across the cycle in both groups...
April 18, 2024: J Psychopathol Clin Sci
#33
JOURNAL ARTICLE
Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.
Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Zineb Imane, Brittany Resnick, Evangelia Williams, Rui Pedro Galão, Richard Caswell, James Russ-Silsby, Yoann Seeleuthner, Darawan Rinchai, Iris Fagniez, Basilin Benson, Matthew J Dufort, Cate Speake, Megan E Smithmyer, Michelle Hudson, Rebecca Dobbs, Zoe Quandt, Andrew T Hattersley, Peng Zhang, Stephanie Boisson-Dupuis, Mark S Anderson, Jean-Laurent Casanova, Timothy I Tree, Richard A Oram
We previously reported two siblings with inherited PD-1 deficiency who died from autoimmune pneumonitis at 3 and 11 years of age after developing other autoimmune manifestations, including type 1 diabetes (T1D). We report here two siblings, aged 10 and 11 years, with neonatal-onset T1D (diagnosed at the ages of 1 day and 7 wk), who are homozygous for a splice-site variant of CD274 (encoding PD-L1). This variant results in the exclusive expression of an alternative, loss-of-function PD-L1 protein isoform in overexpression experiments and in the patients' primary leukocytes...
June 3, 2024: Journal of Experimental Medicine
#34
JOURNAL ARTICLE
Rajesh Sinha, Shahnaz Anjum, Aafreen Bari
We describe and assess the efficiency of a novel technique of placing implantable collamer lens (ICL) footplates in the sulcus in poorly dilated pupils utilizing perioptic holes and two instruments simultaneously (Sinskey hook and ICL manipulator). Twelve eyes of 10 patients underwent ICL implantation through this technique. The technique employs a bimanual approach engaging perioptic holes in the eyes with intraoperative miosis. Perioptic holes were engaged with a Sinskey hook and pulled slightly back, while the footplates were tucked under the iris by using an ICL manipulator...
April 16, 2024: Indian Journal of Ophthalmology
#35
JOURNAL ARTICLE
Kyungho Lee, Sepideh Gharaie, Johanna T Kurzhagen, Andrea M Newman-Rivera, Lois J Arend, Sanjeev Noel, Hamid Rabb
T cells mediate organ injury and repair. A proportion of unconventional kidney T cells called double-negative (DN) T cells (TCR+ CD4- CD8- ), with anti-inflammatory properties, were previously demonstrated to protect from early injury in moderate experimental AKI. However, their role in repair after AKI has not been studied. We hypothesized that DN T cells mediate repair after severe AKI. C57B6 mice underwent severe (40min) unilateral ischemia-reperfusion injury (IRI). Kidney DN T cells were studied by flow cytometry and compared to gold-standard anti-inflammatory CD4+ Tregs...
April 18, 2024: American Journal of Physiology. Renal Physiology
#36
JOURNAL ARTICLE
Ioannis Kouroudis, Kenedy Tabah Tanko, Masoud Karimipour, Aziz Ben Ali, D Kishore Kumar, Vediappan Sudhakar, Ritesh Kant Gupta, Iris Visoly-Fisher, Monica Lira-Cantu, Alessio Gagliardi
The commercial development of perovskite solar cells (PSCs) has been significantly delayed by the constraint of performing time-consuming degradation studies under real outdoor conditions. These are necessary steps to determine the device lifetime, an area where PSCs traditionally suffer. In this work, we demonstrate that the outdoor degradation behavior of PSCs can be predicted by employing accelerated indoor stability analyses. The prediction was possible using a swift and accurate pipeline of machine learning algorithms and mathematical decompositions...
April 12, 2024: ACS Energy Letters
#37
Sadhvi G Naik, Muness Akhtarkhavari, Aradhana Nagarsekar, Meena A Aras, Vidya Chitre
Trauma, cancer, and congenital defects may all result in the loss of an eye. This leads to significant emotional and physical challenges in an individual's life. In such cases, cautious preoperative, surgical, and prosthetic planning employing a multidisciplinary approach is essential for effective rehabilitation. Iris positioning is one of the crucial steps in the fabrication of a customized ocular prosthesis. Iris positioning is a technique-sensitive process, hence visual evaluation by itself could not provide reliable results...
March 2024: Curēus
#38
Pedja Kovacevic, Sasa Dragic, Milka Jandric, Danica Momcicevic, Vedrana Malesevic, Tijana Kovacevic, Marijana Matejic-Spasic, Tanja Knezevic, Biljana Zlojutro
Drowning remains a significant global health concern, claiming over 300,000 lives annually, with a disproportionate impact on young individuals in low-and middle-income countries. Conventional mechanical ventilation, while common, falls short in addressing the hypoxemia and hypercapnia often observed in severe near-drowning cases. Veno-venous extracorporeal membrane oxygenation (vvECMO) emerges as a critical intervention for cardiopulmonary failure post-drowning. This case report delves into the pivotal role of ischemia-reperfusion injury (IRI) in a near-drowning-related pathology...
2024: Frontiers in Medicine
#39
JOURNAL ARTICLE
Nienke D Sijtsema, Iris Lauwers, Gerda M Verduijn, Mischa S Hoogeman, Dirk H J Poot, Juan A Hernandez-Tamames, Aad van der Lugt, Marta E Capala, Steven F Petit
BACKGROUND AND PURPOSE: Diffusion-weighted imaging (DWI) is a promising technique for response assessment in head-and-neck cancer. Recently, we optimized Non-Gaussian Intravoxel Incoherent Motion Imaging (NG-IVIM), an extension of the conventional apparent diffusion coefficient ( ADC ) model, for the head and neck. In the current study, we describe the first application in a group of patients with human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma...
April 2024: Physics and Imaging in Radiation Oncology
#40
JOURNAL ARTICLE
Iris van der Heide, Anneke L Francke, Carola Döpp, Marianne Heins, Hein P J van Hout, Robert A Verheij, Karlijn J Joling
INTRODUCTION: This paper provides insight into the development of the Dutch Dementia Care and Support Registry and the lessons that can be learned from it. The aim of this Registry was to contribute to quality improvement in dementia care and support. METHODS: This paper describes how the Registry was set up in four stages, reflecting the four FAIR principles: the selection of data sources (Findability); obtaining access to the selected data sources (Accessibility); data linkage (Interoperability); and the reuse of data (Reusability)...
April 2024: Learning Health Systems
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