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https://www.readbyqxmd.com/read/28094762/persistent-mullerian-duct-syndrome-with-transverse-testicular-ectopia-a-novel-amh-receptor-mutation
#1
Özlem Korkmaz, Samim Özen, Nurhan Özcan, Petek Bayındır, Sait Şen, Hüseyin Onay, Damla Gökşen, Ali Avanoğlu, Ferda Özkınay, Şükran Darcan
Persistent Mullerian duct syndrome is the result of either anti-Mullerian hormone (AMH) deficiency or AMH receptor resistance. A long tubular structure (testis/?) was palpated during the physical examination of a 13-month-old male patient who admitted because of bilateral undescended testes. Structures suggestive of ovaries, a uterus and fallopian tubes were observed during laparoscopic examination of the ectopic testis. AMHR2 gene sequence analysis performed wıth a preliminary diagnosis of AMH receptor resistance revealed a previously unreported homozygous c...
January 17, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28070708/delayed-treatment-of-undescended-testes-may-promote-hypogonadism-and-infertility
#2
Julia Rohayem, Alessandra Luberto, Eberhard Nieschlag, Michael Zitzmann, Sabine Kliesch
CONTEXT: Undescended testes at birth may be caused by testosterone deficiency during fetal development. It is unclear whether the process of failed descent contributes to permanent endocrine impairment. OBJECTIVES: To evaluate the impact of age at treatment of undescended testes on endocrine and spermatogenic testicular function in middle-aged men. PATIENTS AND METHODS: Reproductive hormone and semen data of 357 men with previously undescended testes were evaluated with respect to age at correction of testicular position and compared to those of 709 controls with eutopic testes at birth and normozoospermia...
January 9, 2017: Endocrine
https://www.readbyqxmd.com/read/28059674/coronal-clival-cleft-in-charge-syndrome
#3
Eman Mahdi, Matthew T Whitehead
CHARGE syndrome is a genetic disorder with multi-systemic congenital anomalies, most commonly including coloboma, heart malformations, choanal atresia, developmental delay, and genital and ear anomalies. The diagnostic criteria for CHARGE syndrome has been refined over the years. However, there are limited reports describing skullbase and craniocervical junction abnormalities. These osseous malformations are often under recognized, especially on MRI. We report here a case of CHARGE syndrome with colobomas, cleft lip and palate, patent ductus arteriosus, undescended testes, and a coronal clival cleft which has not been previously depicted in CHARGE syndrome...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28029537/-congenital-undescended-testis-should-open-processus-vaginalis-have-any-impact-on-the-elected-surgical-approach
#4
E Bey, O Gaget, J Jund, C Overs, O Skowron
PURPOSE: Compare the position of the undescended testis at clinical examination and under general anesthesia with the patency of an open processus vaginalis. PATIENTS AND METHODS: We included children from 2 to 18 years of age operated for a unilateral or bilateral undescended testis between January 2006 and April 2014 at the Annecy Genevois hospital, France. The analysis was conducted considering that the individual was the testis. Testicular position before surgery, under general anesthesia and patency of open processus vaginalis as a surgical finding were prospectively recorded...
October 28, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/28027755/a-preliminary-study-of-shear-wave-elastography-for-the-evaluation-of-unilateral-palpable-undescended-testes
#5
Ayse Kalyoncu Ucar, Deniz Alis, Cesur Samanci, Mine Aslan, Hatice Arioz Habibi, Atilla Suleyman Dikici, Yesim Namdar, Mehmet Hamza Gultekin, Bulent Onal, Ibrahim Adaletli
OBJECTIVES: We sought to compare unilateral palpable undescended testes and contralateral descended testes using shear wave elastography (SWE) to show potential quantitative differences in elasticity patterns, which might reflect the histologic features. METHODS: Approval for this prospective study was obtained from the local ethics committee. A total of 29 patients (mean age, 7.52 years; range, 1-18 years) with unilateral palpable undescended testes and contralateral descended testes were examined by greyscale ultrasonography and SWE between February 2015 and April 2016...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28002344/the-role-of-ultrasound-in-the-management-of-undescended-testes-before-and-after-orchidopexy-an-update
#6
Grzegorz Jedrzejewski, Andrzej Pawel Wieczorek, Pawel Osemlak, Pawel Nachulewicz
The aim of this study was to evaluate the testicular volume and structure using ultrasound (US) before and up to 3 years after orchidopexy in children with different age.A total of 128 patients underwent orchidopexy for undescended testes. Afterwards, patients were invited for annual follow-up and control scrotal US. The total number of analyzed testes after orchidopexy was 184. Patients were divided according to age at the time of surgery: group I (2-4 years old), group II (5-7), and group III (8-10). In all patients, the testicular volume ratio was calculated as the operated testes volume versus the control testes mean volume...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27895374/pediatric-laparoscopic-surgery-initial-experience-from-pakistan-first-100-cases-in-single-center
#7
Hassan Ishaq, Saqib Hamid Qazi, Sohail Dogar, Muhammad Younus Khan Durrani, Ahmad Vaqas Faruque
In a developing country like Pakistan, laparoscopic surgeries are not considered favourable by many, possibly because of high costs or a lack of expertise. It is an established fact that laparoscopic surgery offers better surgical treatments with a shorter hospital stay and fewer complications. The current retrospective study was conducted at a tertiary care hospital in Karachi and comprised of laparoscopy cases performed by a single surgeon from March 2012 to September of 2014. A total of 100laparoscopic surgeries were performed; mostly appendectomies 49(49%) and undescended testes (UDTs) 34(34%)...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27867845/current-management-of-non-palpable-testes-a-literature-review-and-clinical-results
#8
REVIEW
Ximena Sepúlveda, Pedro-José López Egaña
Cryptorchidism is a common pathology that occurs in 3% in full term newborns, and it decreases to 0.8-1.2% at 1 year of age. Nearly a 20% of undescended testes are non-palpable. Various surgical treatments have been described, but its management is still controversial. A literature review was made of non-palpable testes, analysing diagnostic tools, treatment and its results. Additionally we reviewed non-palpable testes cases treated in our centre in the last 20 years. Different techniques are described for the management of non-palpable testes; with or without section of the spermatic vessels and/or in 1 or 2 stages...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27866870/commentary-to-management-of-undescended-testes-european-association-of-urology-european-society-for-paediatric-urology-guidelines
#9
Thomas F Kolon
No abstract text is available yet for this article.
December 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27845220/staged-fowler-stephens-and-single-stage-laparoscopic-orchiopexy-for-intra-abdominal-testes-is-there-a-difference-a-single-institution-experience
#10
Alireza Alam, Joan C Delto, Ruben Blachman-Braun, George Wayne, Angela G Mittal, Miguel Castellan, Kristin Kozakowski, Andrew Labbie, Rafael Gosalbez
OBJECTIVE: To compare single-stage laparoscopic orchiopexy (SSLO) and staged Fowler-Stephens (SFS) procedures in the management of intra-abdominal undescended testes, and to analyze postoperative atrophy and malpositioning as end points. MATERIALS AND METHODS: A retrospective chart review identified laparoscopic orchiopexy patients with intra-abdominal testes between November 2006 and November 2014. Of 167 patients who had laparoscopic orchiopexy, 73 (85 testes) were identified as having laparoscopic orchiopexy...
November 11, 2016: Urology
https://www.readbyqxmd.com/read/27785439/malignancy-in-disorders-of-sex-development
#11
REVIEW
Martin Kathrins, Thomas F Kolon
Disorders of sex development (DSD) represent a spectrum of conditions in which chromosomal, gonadal, or anatomic sex are atypical and affect 1 in 4,500-5,000 live births. The diagnosis of DSD raises concerns of tumor risk and treatment as well as future fertility preservation. We review the current understanding of the types of gonadal tumors that arise in DSD patients as well as possible markers and treatment. The goal is to inform the members of the DSD team (urologist, endocrinologist, geneticist, psychologist) of the latest findings regarding malignancy in DSD...
October 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27722006/a-unique-case-of-intraabdominal-polyorchidism-a-case-study
#12
Javier Otero, Natalie Ben-Yakar, Biruk Alemayehu, Steven D Kozusko, Frank Borao, Thomas S Vates Iii
Background. Polyorchidism, alternatively supernumerary testes (SNT), is a condition where an individual is born with more than two testicles. This congenital anomaly is quite rare and the literature has described various presentations. Questions/Purposes. To our knowledge, this presentation of polyorchidism has yet to be described in the literature. The goal of this case study is to add to the pediatric, general, and urologic surgery's body of knowledge of the subject matter. Case Study. A nine-month-old boy was admitted for an impalpable right testis and phimosis...
2016: Case Reports in Urology
https://www.readbyqxmd.com/read/27715712/us-of-the-inguinal-canal-comprehensive-review-of-pathologic-processes-with-ct-and-mr-imaging-correlation
#13
Margarita V Revzin, Devrim Ersahin, Gary M Israel, Jonathan D Kirsch, Mahan Mathur, Jamal Bokhari, Leslie M Scoutt
Ultrasonography (US) has a fundamental role in the initial examination of patients who present with symptoms indicating abnormalities of the inguinal canal (IC), an area known for its complex anatomy. A thorough understanding of the embryologic and imaging characteristics of the contents of the IC is essential for any general radiologist. Moreover, an awareness of the various pathologic conditions that can affect IC structures is crucial to preventing misdiagnoses and ensuring optimal patient care. Early detection of IC abnormalities can reduce the risk of morbidity and mortality and facilitate proper treatment...
October 7, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27687532/management-of-undescended-testes-european-association-of-urology-european-society-for-paediatric-urology-guidelines
#14
REVIEW
Christian Radmayr, Hasan S Dogan, Piet Hoebeke, Radim Kocvara, Rien Nijman, Raimund Stein, Shabnam Undre, Serdar Tekgul
CONTEXT: Undescended testis is the most common endocrinological disease in the male newborn period. Incidence varies between 1.0% and 4.6% in full-term neonates, with rates as high as 45% in preterm neonates. Failure or delay of treatment can result in reduced fertility and/or increased testicular cancer risk in adulthood. OBJECTIVE: To provide recommendations for the diagnosis and treatment of boys with undescended testes which reduce the risk of impaired fertility and testicular cancer in adulthood...
December 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27649393/what-animal-models-of-testicular-descent-and-germ-cell-maturation-tell-us-about-the-mechanism-in-humans
#15
John Medwyn Hutson, Ruili Li, Jaya Vikraman, Moshe Loebenstein
Testicular descent occurs in most mammals in two main steps that have different hormonal control and anatomical processes. The evolution of testicular descent reveals the same basic processes in humans and animals, with minor differences in timing and anatomy, especially the location of the scrotum and the processus vaginalis. Animal models are useful as they reveal some embryological processes that cannot be studies easily in humans, such as the potential role of the mammary line and the role of the genitofemoral nerve...
October 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27631723/surgical-management-of-the-undescended-testis-recent-advances-and-controversies
#16
Jack S Elder
Undescended testis (UDT) is the most common disorder of sexual development in boys and affects 3.5% of male newborns. Although approximately half of newborn UDTs descend spontaneously, some boys develop an ascending testis later in childhood. Recent guideline recommendations advocate orchiopexy by 18 months of age to maximize potential for fertility and perhaps reduce the risk for testicular carcinoma in the future. For palpable testes, a standard inguinal approach is appropriate. However, the prescrotal approach is often effective for low inguinal testes and reduces surgical time and patient discomfort with an equivalent success rate in boys with an ascending testis...
October 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27631023/immediate-postpartum-intrauterine-contraceptive-device-insertions-in-caesarean-and-vaginal-deliveries-a-comparative-study-of-follow-up-outcomes
#17
Reetu Hooda, Sonika Mann, Smiti Nanda, Anjali Gupta, Hemant More, Jaikrit Bhutani
Background. Immediate postpartum intrauterine contraceptive device (IPPIUCD) is a lucrative postpartum family planning method which provides effective reversible contraception to women in the delivery setting. Our aim was to study the clinical outcomes of IPPIUCD insertions and compare them as a factor of route of insertion (vaginal versus caesarean). Methods. This is a retrospective analytical study done in a tertiary care teaching institute. A Cohort of 593 vaginal and caesarean deliveries with IPPIUCD insertions, over a two-year period, was studied and compared for follow-up results...
2016: International Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/27628837/re-pre-and-postoperative-status-of-gonadotropins-fsh-and-lh-and-inhibin-b-in-relation-to-testicular-histopathology-at-orchiopexy-in-infant-boys-with-unilateral-undescended-testes
#18
https://www.readbyqxmd.com/read/27614808/the-diagnostic-impact-of-testicular-biopsies-for-intratubular-germ-cell-neoplasia-in-cryptorchid-boys-and-the-subsequent-risk-of-testicular-cancer-in-men-with-prepubertal-surgery-for-syndromic-or-non-syndromic-cryptorchidism
#19
Lene Osterballe, Erik Clasen-Linde, Dina Cortes, Gerda Engholm, Rasmus Hertzum-Larsen, Susanne Reinhardt, Jorgen Thorup
INTRODUCTION: Cryptorchidism is a risk factor for testicular cancer in adult life. It remains unclear how prepubertal surgery for cryptorchidism impacts later development of adult testicular cancer. The aim of study was to investigate tools to identify the cryptorchid boys who later develop testicular cancer. METHODS: The study cohort consisted of 1403 men operated prepubertally/pubertally for undescended testis between 1971 and 2003. At surgery testicular biopsies were taken from the cryptorchid testes...
August 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27614119/urological-findings-in-beckwith-wiedemann-syndrome-with-chromosomal-duplications-of-11p15-5-evaluation-and-management
#20
Carmen C Tong, Kelly A Duffy, David I Chu, Dana A Weiss, Arun K Srinivasan, Douglas A Canning, Jennifer M Kalish
Beckwith-Wiedemann Syndrome (BWS) is an overgrowth disorder with various congenital anomalies. Although the most classic constellation includes macrosomia, macroglossia, and omphalocele, nephrourological findings are commonly associated with BWS. Clinical presentation is highly variable because of its complex molecular heterogeneity, which involves changes in DNA methylation and disruption of growth regulatory genes. We report 3 pediatric patients, ages 13 months to 3 years old, who presented with clinical features consistent with BWS...
September 7, 2016: Urology
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