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warm ischemia injury and reperfusion

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https://www.readbyqxmd.com/read/29762455/the-anti-inflammatory-effect-of-hydrogen-on-lung-transplantation-model-of-pulmonary-microvascular-endothelial-cells-during-cold-storage-period
#1
Guangchao Zhang, Zhe Li, Chao Meng, Jiyu Kang, Mengdi Zhang, Liangjuan Ma, Huacheng Zhou
BACKGROUND: Lung ischemia-reperfusion injury (LIRI) remains an important factor for the early mortality of lung transplantations. Hydrogen (H2) can attenuate lung injury and improve lung function in animal experiments. In previous studies, pulmonary microvascular endothelial cells (PMVECs) were used to simulate LIRI. We hypothesized that H2 can alleviate inflammatory injury in a PMVECs lung transplantation model in the cold ischemia phase. METHODS: PMVECs were divided into 4 groups: Blank, Control, Oxygen (O2), and Hydrogen (H2)...
May 14, 2018: Transplantation
https://www.readbyqxmd.com/read/29707971/human-multilineage-differentiating-stress-enduring-cells-exert-pleiotropic-effects-to-ameliorate-acute-lung-ischemia-reperfusion-injury-in-a-rat-model
#2
Hiroshi Yabuki, Shohei Wakao, Yoshihiro Kushida, Mari Dezawa, Yoshinori Okada
Posttransplantation lung ischemia-reperfusion (IR) injuries affect both patient survival and graft function. In this study, we evaluated the protective effects of infused human multilineage-differentiating stress-enduring (Muse) cells, a novel, easily harvested type of nontumorigenic endogenous reparative stem cell, against acute IR lung injury in a rat model. After a 2-h warm IR injury induction in a left rat lung, human Muse cells, human mesenchymal stem cells (MSCs), and vehicle were injected via the left pulmonary artery after reperfusion...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29683999/normothermic-ex-vivo-kidney-perfusion-reduces-warm-ischemic-injury-of-porcine-kidney-grafts-retrieved-after-circulatory-death-dcd
#3
Matyas Hamar, Peter Urbanellis, Moritz Johann Kaths, Dagmar Kollmann, Ivan Linares, Sujani Ganesh, Aryn Wiebe, Jun Yu Cen, Paul M Yip, Rohan John, Ana Konvalinka, Istvan Mucsi, Anand Ghanekar, Darius Bagli, David R Grant, Lisa A Robinson, Markus Selzner
BACKGROUND: Cold storage is poorly tolerated by kidney grafts retrieved after Donation after Circulatory Death (DCD). It has been determined that normothermic ex vivo kidney perfusion (NEVKP) preservation decreases injury by minimizing cold ischemic storage. The impact of NEVKP on warm ischemic injury is unknown. METHODS: We compared pig kidneys retrieved after 30minutes warm ischemia and immediate transplantation (no-preservation) with grafts that were exposed to 30min of warm ischemia plus 8hr NEVKP or plus 8hr SCS...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29677080/corm-401-reduces-ischemia-reperfusion-injury-in-an-ex-vivo-renal-porcine-model-of-the-donation-after-cardiac-death
#4
Rabindra N Bhattacharjee, Mahms Richard-Mohamed, Qizhi Sun, Aaron Haig, Ghaleb Aboalsamh, Peter Barrett, Richard Mayer, Ibrahim Alhasan, Karen Pineda-Solis, Larry Jiang, Hajed Alharbi, Manujendra Saha, Eric Patterson, Alp Sener, Gediminas Cepinskas, Anthony M Jevnikar, Patrick P W Luke
BACKGROUND: Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CORM-401 has recently been synthesized which can efficiently deliver 3 molar equivalents of CO. We report the ability of this anti-inflammatory CORM-401 to reduce ischemia reperfusion injury associated with prolonged cold storage of renal allografts obtained from donation after cardiac death in a porcine model of transplantation...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29668777/combined-effects-of-melatonin-and-topical-hypothermia-on-renal-ischemia-reperfusion-injury-in-rats
#5
Pablo Cambeses Souza, Emanuel Burck Dos Santos, Guilherme Lang Motta, Silvia Regina Bona, Pedro Guilherme Schaefer, Daniela Campagnol, Tiago Bortolini, Carlos Otávio Corso
PURPOSE: To evaluate whether their combination was more effective than either alone in decreasing renal damage due to ischemia/reperfusion (I/R) injury in rats. METHODS: Thirty-two Wistar rats were assigned to four groups. Following right nephrectomy, their left kidneys were subjected to warm ischemia (IR), cold ischemia (TH+IR), intraperitoneal injection of 10 mg/kg melatonin (MEL+IR), or injection of 10 mg/kg melatonin followed by cold ischemia (MEL+TH+IR). Eight randomly assigned right kidneys constituted the control group...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29611214/hydrogen-gas-does-not-ameliorate-renal-ischemia-reperfusion-injury-in-a-preclinical-model
#6
Sarah A Hosgood, Tom Moore, Maria Qurashi, Tom Adams, Michael L Nicholson
In renal transplantation, ischemia reperfusion injury impairs early graft function and can reduce long term graft survival. Hydrogen has antioxidant and anti-inflammatory properties that can reduce the effects of ischemic injury. The aim of this study was to examine the effects of hydrogen gas administered during reperfusion in a preclinical model of kidney ischemia reperfusion injury. Porcine kidneys underwent 15 min of warm ischemia followed by 22 h of cold ischemia. They were then reperfused for 6 h with whole autologous blood on an ex vivo reperfusion circuit...
April 2, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29607529/transplantation-of-cold-stored-porcine-kidneys-after-controlled-oxygenated-rewarming
#7
Anja Gallinat, Jing Lu, Charlotte von Horn, Moritz Kaths, Marc Ingenwerth, Andreas Paul, Thomas Minor
The concept of "controlled oxygenated rewarming" (COR) using ex vivo machine perfusion after cold storage was evaluated as tool to improve renal graft function after transplantation. Renal function after 20 min warm ischemia and 21 h cold storage was studied in an auto-transplant model in pigs (25-30 kg, n = 6 per group). In the study group, preimplant ex vivo machine perfusion for 90 min was added after cold storage, including gentle warming up of the graft to 20°C (COR). Kidneys that were only cold stored for 21 h served as controls...
April 1, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29603199/indirubin-and-nad-prevent-mitochondrial-ischemia-reperfusion-damage-in-fatty-livers
#8
João Soeiro Teodoro, Ana Teresa Varela, Filipe Valente Duarte, Ana Patrícia Gomes, Carlos Marques Palmeira, Anabela Pinto Rolo
BACKGROUND: Fatty livers are considerably more susceptible to acute stressors, such as ischemia/reperfusion (I/R). Since the incidence of I/R is high due to surgical events and some pathologies, there is an urgent need to find strategies against I/R injury (I/RI) in fatty livers. We postulate that an acute pre-treatment with Indirubin-3'-oxime (Ind) or NAD+ prevents mitochondrial dysfunction associated with warm I/RI in fatty livers. MATERIALS AND METHODS: Zucker fatty rats were subjected to warm ischemia and 12 hrs of reperfusion...
March 30, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29596325/preconditioning-like-properties-of-short-term-hypothermia-in-isolated-perfused-rat-liver-iprl-system
#9
Norma Alva, Raquel G Bardallo, David Basanta, Jesús Palomeque, Teresa Carbonell
Hypothermia may attenuate the progression of ischemia-induced damage in liver. Here, we determined the effects of a brief cycle of hypothermic preconditioning applied before an ischemic/reperfusion (I/R) episode in isolated perfused rat liver (IPRL) on tissue damage and oxidative stress. Rats (male, 200-250 g) were anaesthetised with sodium pentobarbital (60 mg·kg-1 i.p) and underwent laparatomy. The liver was removed and perfused in a temperature-regulated non-recirculating system. Livers were randomly divided into two groups ( n = 6 each group)...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29589772/alda-1-an-aldh2-activator-protects-against-hepatic-ischemia-reperfusion-injury-in-rats-via-inhibition-of-oxidative-stress
#10
Tao Zhang, Qiang Zhao, Fang Ye, Chan-Yan Huang, Wan-Mei Chen, Wen-Qi Huang
AIM: Previous studies have proved that activation of aldehyde dehydrogenase two (ALDH2) can attenuate oxidative stress through clearance of cytotoxic aldehydes, and can protect against cardiac, cerebral and lung ischemia/reperfusion (I/R) injuries. In this study, we investigated the effects of the ALDH2 activator Alda-1 on hepatic I/R injury. METHODS: Partial warm ischemia was performed in the left and middle hepatic lobes of Sprague-Dawley rats for 1 h, followed by 6 h of reperfusion...
March 28, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29569721/resolvin-d1-attenuates-liver-ischaemia-reperfusion-injury-through-modulating-thioredoxin-2-mediated-mitochondrial-quality-control
#11
Jung-Woo Kang, Hyo-Sun Choi, Sun-Mee Lee
BACKGROUND AND PURPOSE: Liver ischaemia and reperfusion (IR) injury is a sterile inflammatory response involving production of ROS. Mitochondrial homeostasis is maintained by mitochondrial quality control (QC). Thioredoxin (TRX) 2 is a key mitochondrial redox-sensitive protein. Resolvin D1 (RvD1), a specialized pro-resolving lipid mediator, exerts anti-inflammatory and antioxidant activities. We investigated mechanisms of RvD1 protection against IR-induced oxidative damage to the liver, focusing on TRX2-mediated mitochondrial QC...
March 23, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29538260/impact-of-mitochondrial-permeability-on-endothelial-cell-immunogenicity-in-transplantation
#12
Danh T Tran, Scott Esckilsen, Jennifer Mulligan, Shikhar Mehrotra, Carl Atkinson, Satish N Nadig
BACKGROUND: Microvascular endothelial cells (ECs) are central to an allograft's immunogenicity. Cold ischemia and reperfusion injury associated with static cold storage and warm reperfusion activates ECs and increases the immunogenicity of the allograft. After reperfusion, mitochondrial permeability transition pore (mPTP) opening contributes to mitochondrial dysfunction in the allograft, which correlates to alloimmune rejection. Current understanding of this relationship, however, centers on the whole allograft instead of ECs...
June 2018: Transplantation
https://www.readbyqxmd.com/read/29470355/effects-of-warm-versus-cold-ischemic-donor-lung-preservation-on-the-underlying-mechanisms-of-injuries-during-ischemia-and-reperfusion
#13
Ilker Iskender, Marcelo Cypel, Tereza Martinu, Manyin Chen, Jin Sakamoto, Hyunhee Kim, Keke Yu, Huiqing Lin, Zehong Guan, Kohei Hashimoto, Thomas K Waddell, Mingyao Liu, Shaf Keshavjee
BACKGROUND: Ischemia-reperfusion injury related to lung transplantation is a major contributor to early postoperative morbidity and mortality. We hypothesized that donation after cardiac death donor lungs experience warm ischemic conditions that activate different injurious mechanisms compared with donor lungs that undergo prolonged cold ischemic conditions. METHODS: Rat donor lungs were preserved under different cold ischemic times (CIT) (12 hours or 18 hours), or under warm ischemia time (WIT) (3 hours) after cardiac death, followed by single left lung transplantation...
May 2018: Transplantation
https://www.readbyqxmd.com/read/29464890/serelaxin-induces-notch1-signaling-and-alleviates-hepatocellular-damage-in-orthotopic-liver-transplantation
#14
Shoichi Kageyama, Kojiro Nakamura, Bibo Ke, Ronald W Busuttil, Jerzy W Kupiec-Weglinski
Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). We have reported on the crucial role of macrophage Notch1 signaling in mouse warm hepatic IRI model. However, its clinical relevance or therapeutic potential remain unknown. Here, we used Serelaxin (SER), to verify Notch1 induction and putative hepatoprotective function in ischemia-reperfusion-stressed OLT. C57BL/6 mouse livers subjected to extended (18-hour) cold storage were transplanted to syngeneic recipients...
February 21, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29464158/hyperbaric-oxygen-for-ischemia-due-to-injection-of-cosmetic-fillers-case-report-and-issues
#15
Raven Henderson, Debra A Reilly, Jeffrey S Cooper
Natural and synthetic fillers have revolutionized aesthetic facial rejuvenation and soft-tissue augmentation. We present a case highlighting the dangers of filler self-injection. A 37-year-old woman self-injected a dermal filler around both temples. She immediately experienced left--side hearing loss, blanching over the left face, and pain. Prompt treatment with hyaluronidase, topical nitro paste, and warm compresses ensued. An emergency computed tomography angiogram showed occlusion of a superficial temporal artery branch...
January 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29452207/glycogen-synthase-kinase-3%C3%AE-promotes-liver-innate-immune-activation-by-restraining-amp-activated-protein-kinase-activation
#16
Haoming Zhou, Han Wang, Ming Ni, Shi Yue, Yongxiang Xia, Ronald W Busuttil, Jerzy W Kupiec-Weglinski, Ling Lu, Xuehao Wang, Yuan Zhai
BACKGROUND & AIMS: Glycogen synthase kinase 3β (Gsk3β [Gsk3b]) is a ubiquitously expressed kinase with distinctive functions in different types of cells. Although its roles in regulating innate immune activation and ischaemia and reperfusion injuries (IRIs) have been well documented, the underlying mechanisms remain ambiguous, in part because of the lack of cell-specific tools in vivo. METHODS: We created a myeloid-specific Gsk3b knockout (KO) strain to study the function of Gsk3β in macrophages in a murine liver partial warm ischaemia model...
February 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29448828/role-of-terminal-warm-blood-cardioplegia-in-complex-congenital-heart-surgery
#17
Pribadi Wiranda Busro, Harvey Romolo, Sudigdo Sastroasmoro, Jusuf Rachmat, Mohammad Sadikin, Anwar Santoso, Cindy Elfira Boom, Suhendro Suwarto, Ahmad Aulia Jusuf
Introduction Myocardial protection is vital to ensure successful open heart surgery. Cardioplegic solution is one method to achieve good myocardial protection. Inevitably, ischemia-reperfusion injury occurs with aortic crossclamping. Histidine-tryptophan-ketoglutarate solution is a frequently used cardioplegia for complex congenital heart surgery. We postulated that addition of terminal warm blood cardioplegia before removal of the aortic crossclamp might improve myocardial protection. Method A randomized controlled trial was conducted on 109 cyanotic patients aged, 1 to 5 years who underwent complex biventricular repair...
March 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29446738/how-do-dendritic-cells-play-the-role-in-ischemia-reperfusion-triggered-kidney-allograft-rejection
#18
Songjie Cai, Naotsugu Ichimaru, Shiro Takahara
In deceased donors, Ischemia/Reperfusion Injury (IRI) is an important cause of allograft dysfunction. Prolonged cold and warm ischemia time leads to a high risk of early post-transplant complications, including acute and chronic rejection. Ischemia not only up-regulates inflammatory cytokines and chemokines, but also enhances the expression of MHC-class II and adhesion molecules on epithelial and dendritic cells. Moreover, the Danger Associated Molecular Patterns (DAMPs) released from stressed or dying cells, not only cause or amplify tissue inflammation and trigger tissue repair in response to IRI, but also act as adjuvants that enhance DC maturation and potentiate the adaptive immune response...
2017: Current Gene Therapy
https://www.readbyqxmd.com/read/29446653/cgas-mediated-autophagy-protects-the-liver-from-ischemia-reperfusion-injury-independent-of-sting
#19
Zhao Lei, Meihong Deng, Zhongjie Yi, Qian Sun, Richard A Shapiro, Hongbo Xu, Tunliang Li, Patricia A Loughran, John E Griepentrog, Hai Huang, Melanie J Scott, Feizhou Huang, Timothy R Billiar
Liver ischemia/reperfusion (I/R) injury occurs through induction of oxidative stress and release of damage-associated molecular patterns (DAMPs), including cytosolic DNA released from dysfunctional mitochondria or from the nucleus. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor known to trigger stimulator of interferon genes (STING) and downstream type1 interferon (IFN-I) pathways, which are pivotal innate immune system responses to pathogen. However, little is known about the role of cGAS/STING in liver I/R injury...
February 15, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29428575/s-adenosylmethionine-attenuates-bile-duct-early-warm-ischemia-reperfusion-injury-after-rat-liver-transplantation
#20
Yong Tang, Hongpeng Chu, Guojun Cao, Xiaolong Du, Xiaobo Min, Chidan Wan
Warm ischemia reperfusion injury (IRI) plays a key role in biliary complication, which is a substantial vulnerability of liver transplantation. The early pathophysiological changes of IRI are characterized by an excessive inflammatory response. S-Adenosylmethionine (SAM) is an important metabolic intermediate that modulates inflammatory reactions; however, its role in bile duct warm IRI is not known. In this study, male rats were treated with or without SAM (170 μmol/kg body weight) after orthotopic autologous liver transplantation...
March 2018: Molecular Immunology
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