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https://www.readbyqxmd.com/read/28933203/in-vivo-antitumor-effect-of-endostatin-loaded-chitosan-nanoparticles-combined-with-paclitaxel-on-lewis-lung-carcinoma
#1
Fang Xie, Rui-Lin Ding, Wen-Feng He, Zong-Jun-Lin Liu, Shao-Zhi Fu, Jing-Bo Wu, Ling-Lin Yang, Sheng Lin, Qing-Lian Wen
The purpose of this study was to prepare endostatin-loaded chitosan nanoparticles (ES-NPs) and evaluate their antitumor effect when combined with paclitaxel (PTX) on Lewis lung carcinoma (LLC) mouse xenografts. ES-NPs were prepared by ionic cross-linking. Characterization of the ES-NPs included size distribution, drug-loading efficiency (DL), and encapsulation efficiency (EE). An in vitro release test was also used to determine the release behavior of the ES-NPs. A subcutaneous LC xenograft model of C57BL/6J mice was established...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28879702/diagnostic-values-of-svegfr-1-and-endostatin-in-malignant-pleural-effusions-in-patients-with-lung-cancer
#2
Ying-Ying Zhu, Hui-Mei Wu, Rong-Yu Liu
BACKGROUND: The diagnosis of malignant pleural effusion (MPE) remains a common clinical challenge because of the sensitivity of conventional cytology for the detection is insufficient. Thus, a sensitive clinical marker for diagnosis is required. The aim of this study was to assess the role of two anti-angiogenic cytokines, soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and endostatin, in diagnosing MPE. METHODS: Effusion samples from 44 patients with MPE caused by lung cancer and from 36 patients with benign pleural effusion (BPE) were collected...
September 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28863122/a-novel-molecular-agent-for-glioma-angiogenesis-imaging
#3
Chuanwang Miao, Wei Zhao, Shuanghu Yuan, Jinming Yu, Shuqiang Zhao, Li Ma, Dexian Zhang, Xudong Hu
BACKGROUND: Gliomas are rich in blood vessels and are the most primary and malignant type of brain tumor affecting the central nervous system. A few fluorine-18 (F)-labeled imaging agents can be used for imaging of tumor angiogenesis. In the current study, F-labeled recombinant human endostatin (rh-endostatin) was developed and evaluated as a probe for PET imaging of tumor angiogenesis. MATERIALS AND METHODS: F-fluorobenzoyl-endostatin (F-FB-endostatin) was synthesized from radiolabeling of rh-endostatin with N-succinimidyl-4-F-fluorobenzoate produced by a facile module-assisted radiosynthesis procedure...
August 31, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28857121/assessment-of-plasma-endostatin-to-predict-acute-kidney-injury-in-critically-ill-patients
#4
J Mårtensson, S T Vaara, V Pettilä, T Ala-Kokko, S Karlsson, O Inkinen, A Uusaro, A Larsson, M Bell
BACKGROUND: We evaluated whether plasma endostatin predicts acute kidney injury (AKI), need for renal replacement therapy (RRT), or death. METHODS: Prospective, observational, multicenter study from 1 September 2011 to 1 February 2012 with data from 17 intensive care units (ICUs) in Finland. RESULTS: A total of 1112 patients were analyzed. We measured plasma endostatin within 2 h of ICU admission. Early AKI (KDIGO stage within 12 h of ICU admission) was found in 20% of the cohort, and 18% developed late AKI (KDIGO criteria > 12 h from ICU admission)...
August 31, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28835895/antiangiogenic-therapy-for-diabetic-nephropathy
#5
REVIEW
Katsuyuki Tanabe, Yohei Maeshima, Yasufumi Sato, Jun Wada
Angiogenesis has been shown to be a potential therapeutic target for early stages of diabetic nephropathy in a number of animal experiments. Vascular endothelial growth factor (VEGF) is the main mediator for abnormal angiogenesis in diabetic glomeruli. Although beneficial effects of anti-VEGF antibodies have previously been demonstrated in diabetic animal experiments, recent basic and clinical evidence has revealed that the blockade of VEGF signaling resulted in proteinuria and renal thrombotic microangiopathy, suggesting the importance of maintaining normal levels of VEGF in the kidneys...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28771739/endostatin-sensitizes-p53-deficient-non-small-cell-lung-cancer-to-genotoxic-chemotherapy-by-targeting-dna-pkcs
#6
Lin Jia, Xin-An Lu, Guanghua Liu, Shan Wang, Min Xu, Yang Tian, Shaosen Zhang, Yan Fu, Yongzhang Luo
Endostatin was discovered as an endogenous angiogenesis inhibitor with broad-spectrum antitumor activities. Although clinical efficacy was observed when combining endostatin with standard chemotherapy for non-small cell lung cancer (NSCLC), as well as other cancer types, the specific mechanisms underlying the benefit of endostatin are not completely understood. Extensive investigations suggest that endostatin is a multifunctional protein possessing more than anti-angiogenic activity. Here, we identified that endostatin exerts a direct chemosensitizing effect on p53-deficient tumor cells...
August 3, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28769047/effect-of-niacin-on-inflammation-and-angiogenesis-in-a-murine-model-of-ulcerative-colitis
#7
Hesham Aly Salem, Walaa Wadie
Butyrate and niacin are produced by gut microbiota, however butyrate has received most attention for its effects on colonic health. The present study aimed at exploring the effect of niacin on experimental colitis as well as throwing some light on the ability of niacin to modulate angiogenesis which plays a crucial role of in the pathogenesis of inflammatory bowel disease. Rats were given niacin for 2 weeks. On day 8, colitis was induced by intrarectal administration of iodoacetamide. Rats were sacrificed on day 15 and colonic damage was assessed macroscopically and histologically...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28755991/optimization-of-high-concentration-endostatin-formulation-harmonization-of-excipients-contributions-on-colloidal-and-conformational-stabilities
#8
Shujing Wang, Xinyi Zhang, Guoliang Wu, Zhou Tian, Feng Qian
Recently, increasing research efforts have been devoted into developing high-concentration protein drugs for subcutaneous injection, especially for those with short half-lives and high-dose requirement. Proteins at high concentrations normally present increased colloidal and structural instability, such as aggregation, fibrillation and gelation, which significantly challenges the high-concentration formulation development of protein drugs. Here we used endostatin, a 20kD recombinant protein, as a model drug for high-concentration formulation optimization...
July 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28736303/the-good-and-the-bad-collagens-of-fibrosis-their-role-in-signaling-and-organ-function
#9
M A Karsdal, S H Nielsen, D J Leeming, L L Langholm, M J Nielsen, T Manon-Jensen, A Siebuhr, N S Gudmann, S Rønnow, J M Sand, S J Daniels, J H Mortensen, D Schuppan
Usually the dense extracellular structure in fibrotic tissues is described as extracellular matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already exemplified by the variant morphological characteristics of fibrosis due to viral versus cholestatic, autoimmune or toxic liver injury, with reticular, chicken wire and bridging fibrosis. Importantly, the overall composition of the ECM, especially the relative amounts of the many types of collagens, which represent the most abundant ECM molecules and which centrally modulate cellular functions and physiological processes, changes dramatically during fibrosis progression...
July 20, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28727816/high-levels-of-flt3-ligand-in-bone-marrow-and-peripheral-blood-of-patients-with-advanced-multiple-myeloma
#10
Normann Steiner, Roman Hajek, Sabina Sevcikova, Bojana Borjan, Karin Jöhrer, Georg Göbel, Gerold Untergasser, Eberhard Gunsilius
INTRODUCTION: Multiple myeloma (MM) is still incurable due to resistance against various therapies. Thus, the identification of biomarkers predicting progression is urgently needed. Here, we evaluated four biomarkers in bone marrow and peripheral blood of MM patients for their prognostic significance. MATERIALS & METHODS: Bone marrow- and peripheral blood plasma levels of FLT3-L, soluble TIE2, endostatin, and osteoactivin were determined in patients with monoclonal gammopathy of undetermined significance (MGUS, n = 14/n = 4), patients with newly diagnosed MM (NDMM, n = 42/n = 31) and patients with relapsed/refractory MM (RRMM, n = 27/n = 16) by sandwich ELISA...
2017: PloS One
https://www.readbyqxmd.com/read/28726562/gene-therapy-for-age-related-macular-degeneration
#11
Nicholas A Moore, Peter Bracha, Rehan M Hussain, Nuria Morral, Thomas A Ciulla
In neovascular age related macular degeneration (nAMD), gene therapy to chronically express anti-vascular endothelial growth factor (VEGF) proteins could ameliorate the treatment burden of chronic intravitreal therapy and improve limited visual outcomes associated with 'real world' undertreatment. Areas covered: In this review, the authors assess the evolution of gene therapy for AMD. Adeno-associated virus (AAV) vectors can transduce retinal pigment epithelium; one such early application was a phase I trial of AAV2-delivered pigment epithelium derived factor gene in advanced nAMD...
October 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28718231/endostatin-concentration-in-plasma-of-healthy-human-volunteers
#12
Inayat Shah, Muhammad Omar Malik, Muhammad Jaffar Khan, Sadia Fatima, Ronald Hugh Baxendale, Syed Hamid Habib
BACKGROUND: Angiogenesis is involved in many cardiovascular and cancerous diseases, including atherosclerosis and is controlled by a fine balance between angiogenic and angiostatic mediators. Endostatin is one of the main angiostatic mediators, and inhibits angiogenesis and prevents progression of atherosclerosis. The available literature shows a broad range of concentrations in relatively small samples of healthy controls and is calculated by using different techniques. This study was aimed to determine the basal endostatin concentration in plasma of healthy volunteers, to fully understand its physiological role...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28716979/blood-biomarkers-for-the-early-diagnosis-of-stroke-the-stroke-chip-study
#13
Alejandro Bustamante, Elena López-Cancio, Sara Pich, Anna Penalba, Dolors Giralt, Teresa García-Berrocoso, Carles Ferrer-Costa, Teresa Gasull, María Hernández-Pérez, Mónica Millan, Marta Rubiera, Pedro Cardona, Luis Cano, Helena Quesada, Mikel Terceño, Yolanda Silva, Mar Castellanos, Moisés Garces, Silvia Reverté, Xavier Ustrell, Rafael Marés, Joan Josep Baiges, Joaquín Serena, Francisco Rubio, Eduardo Salas, Antoni Dávalos, Joan Montaner
BACKGROUND AND PURPOSE: Stroke diagnosis could be challenging in the acute phase. We aimed to develop a blood-based diagnostic tool to differentiate between real strokes and stroke mimics and between ischemic and hemorrhagic strokes in the hyperacute phase. METHODS: The Stroke-Chip was a prospective, observational, multicenter study, conducted at 6 Stroke Centers in Catalonia. Consecutive patients with suspected stroke were enrolled within the first 6 hours after symptom onset, and blood samples were drawn immediately after admission...
July 17, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28714365/conjugation-of-gold-nanoparticles-and-recombinant-human-endostatin-modulates-vascular-normalization-via-interruption-of-anterior-gradient-2-mediated-angiogenesis
#14
Fan Pan, Wende Yang, Wei Li, Xiao-Yan Yang, Shuhao Liu, Xin Li, Xiaoxu Zhao, Hui Ding, Li Qin, Yunlong Pan
Several studies have revealed the potential of normalizing tumor vessels in anti-angiogenic treatment. Recombinant human endostatin is an anti-angiogenic agent which has been applied in clinical tumor treatment. Our previous research indicated that gold nanoparticles could be a nanoparticle carrier for recombinant human endostatin delivery. The recombinant human endostatin-gold nanoparticle conjugates normalized vessels, which improved chemotherapy. However, the mechanism of recombinant human endostatin-gold nanoparticle-induced vascular normalization has not been explored...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28698285/therapeutic-antibody-targeting-of-notch3-signaling-prevents-mural-cell-loss-in-cadasil
#15
Arturo I Machuca-Parra, Alexander A Bigger-Allen, Angie V Sanchez, Anissa Boutabla, Jonathan Cardona-Vélez, Dhanesh Amarnani, Magali Saint-Geniez, Christian W Siebel, Leo A Kim, Patricia A D'Amore, Joseph F Arboleda-Velasquez
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a neurological syndrome characterized by small vessel disease (SVD), stroke, and vascular cognitive impairment and dementia caused by mutations in NOTCH3 No therapies are available for this condition. Loss of mural cells, which encompass pericytes and vascular smooth muscle cells, is a hallmark of CADASIL and other SVDs, including diabetic retinopathy, resulting in vascular instability. Here, we showed that Notch3 signaling is both necessary and sufficient to support mural cell coverage in arteries using genetic rescue in Notch3 knockout mice...
August 7, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28616903/-study-on-the-relationship-between-normalization-of-tumor-microvessels-and-ca9-for-rh-endostatin-to-inhibit-lewis-lung-cancer
#16
Lang He, Yong-Hong Sun, Kang Liu, Xing-Xing Xu, Mi Yang, Xun Wu, Li Jiang
OBJECTIVES: To explore the relationship between normalization of tumor microvessels and CA9 for rh-Endostatin to inhibit Lewis lung cancer (LLC) and the expression level of CA9 in LLC. METHODS: Lewis cells of logarithmic growth phase were collected and made into 1×10(6) mL(-1) cell suspensions were prepared. The transplanted tumor model of LLC was established on C57/BL6 mice by injected 0.2 mL cell suspensions/mice into 40 C57/BL6 mice. 40 LLC mice were randomly divided into control group and rh-ES group (20 mice per group)...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28602918/angiogenic-and-angiostatic-factors-in-renal-scleroderma-associated-vasculopathy
#17
Antonietta Gigante, Luca Navarini, Domenico Margiotta, Antonio Amoroso, Biagio Barbano, Rosario Cianci, Antonella Afeltra, Edoardo Rosato
BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis. Intrarenal resistance index are considered markers of renal vasculopathy. The aim of the study is to evaluate angiogenic and angiostatic factors (VEGF and endostatin) in SSc patients and to correlate with intrarenal hemodynamic parameters...
June 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28599441/effects-of-silencing-endothelin-1-on-invasion-and-vascular-formation-in-lung-cancer
#18
Zhen-Yu Zhang, Li-Li Chen, Wei Xu, Keshavraj Sigdel, Xing-Tang Jiang
Endothelin-1 (ET-1), which exists not only in the vascular endothelium but is also widely present in various tissues and cells, is an important cardiovascular regulatory factor that serves an important role in maintaining the basal vascular tone and homeostasis in the cardiovascular system. In the present study, the ET-1 gene was silenced by RNA interference, and the effects on lung cancer cell proliferation and tumor cell invasion were then detected by Cell Counting kit-8 and Transwell assays. In addition, the expression of apoptosis, growth and invasion-associated proteins, including RhoA/C, vascular endothelial growth factor, pigment epithelium-derived factor, AKT, E-cadherin and cyclooxygenase-2 was evaluated by western blotting upon silencing ET-1...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28598834/do-cell-based-tissue-engineering-products-for-meniscus-regeneration-influence-vascularization
#19
Matthias Koch, Tobias Ehrenreich, Gudrun Koehl, Girish Pattappa, Christian Pfeifer, Markus Loibl, Michael Müller, Michael Nerlich, Peter Angele, Johannes Zellner
BACKGROUND: Meniscus regeneration is observed within the peripheral, vascularized zone but decreases in the inner two thirds alongside the vascularization. Within this avascular area, cell-based tissue-engineering-approaches appears to be a promising strategy for the treatment of meniscal defects. OBJECTIVE: Evaluation of the angiogenic potential of cell-based tissue-engineering-products for meniscus healing. METHODS: Evaluation of angiogenesis induced by rabbit meniscus-pellets, meniscus-cells (MC) or mesenchymal stem-cells (MSC) in cell-based tissue-engineering-products within a rabbit meniscus-ring was performed using a transparent dorsal skin fold chamber in nude mice...
June 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28580627/age-related-modulation-of-angiogenesis-regulating-factors-in-the-swine-meniscus
#20
Alessia Di Giancamillo, Daniela Deponti, Silvia Modina, Irene Tessaro, Cinzia Domeneghini, Giuseppe Maria Peretti
An in-depth knowledge of the native meniscus morphology and biomechanics in its different areas is essential to develop an engineered tissue. Meniscus is characterized by a great regional variation in extracellular matrix components and in vascularization. Then, the aim of this work was to characterize the expression of factors involved in angiogenesis in different areas during meniscus maturation in pigs. The menisci were removed from the knee joints of neonatal, young and adult pigs, and they were divided into the inner, intermediate and outer areas...
June 4, 2017: Journal of Cellular and Molecular Medicine
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