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https://www.readbyqxmd.com/read/28428451/the-relation-between-serum-endostatin-level-and-carotid-atherosclerosis-in-healthy-residents-of-japan-results-from-the-kyushu-and-okinawa-population-study-kops
#1
Yoshifumi Kato, Norihiro Furusyo, Yuuki Tanaka, Takatsugu Ueyama, Sho Yamasaki, Masayuki Murata, Jun Hayashi
AIM: To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy Japanese population. METHODS: Among 1,057 residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (IMT) were successfully measured. RESULTS: The median endostatin level was 63...
April 20, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28425077/unexpected-and-striking-effect-of-heparin-free-dialysis-on-cytokine-release
#2
Alicja Rydzewska-Rosolowska, Joanna Gozdzikiewicz-Lapinska, Jacek Borawski, Ewa Koc-Zorawska, Michal Mysliwiec, Beata Naumnik
Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (heparin-grafted membrane-Evodial) on the release of monocyte chemoattractant protein 1 (MCP-1), endostatin (ES) and activin A (Act-A). Nineteen stable HD patients were dialyzed with or without heparin, and plasma levels of MCP-1, ES and Act-A were measured after such a dialysis...
April 19, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28401019/a-tumor-vessel-targeting-fusion-protein-elicits-a-chemotherapeutic-bystander-effect-in-pancreatic-ductal-adenocarcinoma
#3
Chun-Te Chen, Yi-Chun Chen, Yi Du, Zhenbo Han, Haoqiang Ying, Richard R Bouchard, Jennifer L Hsu, Jung-Mao Hsu, Trevor M Mitcham, Mei-Kuang Chen, Hui-Lung Sun, Shih-Shin Chang, Donghui Li, Ping Chang, Ronald A DePinho, Mien-Chie Hung
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by a prominent desmoplastic stroma that may constrain tumor progression but also limit the access of therapeutic drugs. In this study, we explored a tumor-targeting strategy that enlists an engineered anti-angiogenic protein consisting of endostatin and cytosine deaminase linked to uracil phosphoribosyltransferase (EndoCD). This protein selectively binds to tumor vessels to compromise tumor angiogenesis and converts the non-toxic 5-fluorocytosine (5-FC) to the cytotoxic 5-fluorouracil to produce a chemotherapeutic bystander effect at the pancreatic tumor site...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28361263/serum-biomarkers-of-myocardial-remodeling-and-coronary-dysfunction-in-early-stages-of-hypertrophic-cardiomyopathy-in-the-young
#4
E Fernlund, T Gyllenhammar, R Jablonowski, M Carlsson, A Larsson, J Ärnlöv, P Liuba
Hypertrophic cardiomyopathy (HCM) remains the leading cause of sudden cardiac death in the young. Early markers for HCM are important to identify individuals at risk. The aim of this study was to investigate novel serum biomarkers reflecting myocardial remodeling, microfibrosis, and vascular endotheliopathy in the early stages of familial HCM in young patients. Twenty-three HCM patients, 16 HCM-risk individuals, and 66 controls (median 15 years) underwent echocardiography and serum analysis for cathepsin S, endostatin, myostatin, type I collagen degradation marker (ICTP), matrix metalloproteinase (MMP)-9, vascular endothelial growth factor receptor (VEGFR)-1, and vascular and intercellular adhesion molecules (VCAM, ICAM)...
April 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28359413/limited-added-value-of-circulating%C3%A2-inflammatory-biomarkers-in%C3%A2-chronic-heart%C3%A2-failure
#5
Ståle H Nymo, Pål Aukrust, John Kjekshus, John J V McMurray, John G F Cleland, John Wikstrand, Pieter Muntendam, Ursula Wienhues-Thelen, Roberto Latini, Erik Tandberg Askevold, Jørgen Gravning, Christen P Dahl, Kaspar Broch, Arne Yndestad, Lars Gullestad, Thor Ueland
OBJECTIVES: This study sought to evaluate whether a panel of biomarkers improved prognostication in patients with heart failure (HF) and reduced ejection fraction of ischemic origin using a systematized approach according to suggested requirements for validation of new biomarkers. BACKGROUND: Modeling combinations of multiple circulating markers could potentially identify patients with HF at particularly high risk and aid in the selection of individualized therapy...
April 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28337358/gastric-cancer-and-angiogenesis-is-vegf-a-useful-biomarker-to-assess-progression-and-remission
#6
REVIEW
Filipa Macedo, Kátia Ladeira, Adhemar Longatto-Filho, Sandra F Martins
Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this work was to review the angiogenic biomarkers related to the behavior of GC, documented in the literature. A search of the PubMed database was conducted with the MeSH terms: "Stomach neoplasms/blood [MeSH] or stomach neoplasms/blood supply [MeSH] and angiogenic proteins/blood [Major]". A total of 30 articles were initially collected, and 4 were subsequently excluded...
March 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28193190/enhanced-expression-of-vastatin-inhibits-angiogenesis-and-prolongs-survival-in-murine-orthotopic-glioblastoma-model
#7
Yi Li, Jun Li, Yat Ming Woo, Zan Shen, Hong Yao, Yijun Cai, Marie Chia-Mi Lin, Wai Sang Poon
BACKGROUND: Antiangiogenic therapies are considered promising for the treatment of glioblastoma (GB). The non-collagenous C-terminal globular NC1 domain of type VIII collagen a1 chain, Vastatin, is an endogenous antiangiogenic polypeptide. Sustained enhanced expression of Vastatin was shown to inhibit tumour growth and metastasis in murine hepatocellular carcinoma models. In this study, we further explored the efficacy of Vastatin in the treatment of GB xenografts. METHOD: Treatment of Vastatin was carried out using a nanopolymer gene vector PEI600-CyD-Folate (H1)...
February 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28165807/preparation-of-endostatin-loaded-chitosan-nanoparticles-and-evaluation-of-the-antitumor-effect-of-such-nanoparticles-on-the-lewis-lung-cancer-model
#8
Rui-Lin Ding, Fang Xie, Yue Hu, Shao-Zhi Fu, Jing-Bo Wu, Juan Fan, Wen-Feng He, Yu He, Ling-Lin Yang, Sheng Lin, Qing-Lian Wen
The purpose of this study was to prepare ES-loaded chitosan nanoparticles (ES-NPs) and evaluate the antitumor effect of these particles on the Lewis lung cancer model. ES-NPs were prepared by a simple ionic cross-linking method. The characterization of the ES-NPs, including size distribution, zeta potential, loading efficiency and encapsulation efficiency (EE), was performed. An in vitro release test was also used to determine the release behavior of the ES-NPs. Cell viability and cell migration were assayed to detect the in vitro antiangiogenic effect of ES-NPs...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165672/controlled-release-of-an-endostatin-peptide-using-chitosan-nanoparticles
#9
Sanaz Ebrahimi Samani, Zahra Seraj, Hossein Naderimanesh, Khosro Khajeh, Ahmad Reza Esmaeili Rastaghi, Taher Droudi, Peirhosein Kolivand, Hadi Kazemi, S Mohsen Asghari
Whereas several anticancer peptides are in different stages of clinical development, their administration is limited by fast elimination from the systemic circulation. Peptide loading on nano-carriers can pave the way for their future application. We have recently indicated that a disulfide loop rather than a Zn-binding loop improves the antiangiogenic and antitumor activities of the N-terminal fragment of endostatin. In this study, chitosan nanoparticles (CS NPs) are used for the controlled release of the engineered peptide...
February 6, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28155728/multi-scale-mathematical-modelling-of-tumour-growth-and-microenvironments-in-anti-angiogenic-therapy
#10
Yan Cai, Jie Zhang, Zhiyong Li
BACKGROUND: Angiogenesis, a process of generation of new blood vessels from the pre-existing vasculature, has been demonstrated to be a basic prerequisite for sustainable growth and proliferation of tumour. Anti-angiogenic treatments show normalization of tumour vasculature and microenvironment at least transiently in both preclinical and clinical settings. METHODS: In this study, we proposed a multi-scale mathematical model to simulate the dynamic changes of tumour microvasculature and microenvironment in response to anti-angiogenic drug endostatin (ES)...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28133527/time-course-of-neuroprotection-induced-by-in-vivo-normobaric-hyperoxia-preconditioning-and-angiogenesis-factors
#11
Meisam Shahhoseini, Mohammad Reza Bigdeli
OBJECTIVES: Every year, a large number of people lose their lives due to stroke. Stroke is the second leading cause of death worldwide. Surprisingly, recent studies have shown that preconditioning with hyperoxia (HO) increases tissue tolerance to ischemia, ultimately reducing damages caused by stroke. Addressed in this study are beneficial contributions from HO preconditioning into reduced harm to be incurred by the attack, as well as its effect on the expression levels of vascular endothelial growth factor (VEGF) and endostatin...
January 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28123541/differential-effects-of-recombinant-human-endostatin-treatment-on-differentiated-and-undifferentiated-blood-vessels-in-lewis-lung-cancer
#12
Weijiang Fu, Jing Zhuo, Likuan Hu
In the present study, we evaluated the effects of recombinant human (rh-)endostatin treatment on differentiated and undifferentiated tumor vasculature in Lewis lung cancer for the first time. Lewis lung carcinoma models were established. The animals were treated daily with varying doses of rh-endostatin or physiological saline for 14 days. Intravital microscopy was performed following treatment. The expression of CD31 and CD34 was determined by immunohistochemical staining, and microvessel density (MVD) was determined...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28093678/changes-in-serum-vascular-endothelial-growth-factor-and-endostatin-concentrations-associated-with-circulating-endothelial-progenitor-cells-after-acute-ischemic-stroke
#13
Lixia Xue, Hao Chen, Ting Zhang, Jingjiong Chen, Zhi Geng, Yuwu Zhao
Angiogenesis is an important pathophysiological response to cerebral ischemia, and can be modulated by vascular endothelial growth factor (VEGF) and endostatin. Circulating endothelial progenitor cells (EPCs) also play an important role as an endogenous repair mechanism for ischemic injury. We sought to investigate early changes in the expression of VEGF and endostatin in serum and the circulating EPCs in patients with acute ischemic stroke (AIS) and analyzed the relations between them. The peripheral blood and serum samples were obtained from 30 patients at 1, 3, 5 and 7 d after AIS...
April 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28069826/endostatin-inhibits-androgen-independent-prostate-cancer-growth-by-suppressing-nuclear-receptor-mediated-oxidative-stress
#14
Joo Hyoung Lee, Minsung Kang, Hong Wang, Gurudatta Naik, James A Mobley, Guru Sonpavde, W Timothy Garvey, Victor M Darley-Usmar, Selvarangan Ponnazhagan
Androgen-deprivation therapy has been identified to induce oxidative stress in prostate cancer (PCa), leading to reactivation of androgen receptor (AR) signaling in a hormone-refractory manner. Thus, antioxidant therapies have gained attention as adjuvants for castration-resistant PCa. Here, we report for the first time that human endostatin (ES) prevents androgen-independent growth phenotype in PCa cells through its molecular targeting of AR and glucocorticoid receptor (GR) and downstream pro-oxidant signaling...
April 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28068681/hypoxia-and-hyperoxia-affect-serum-angiogenic-regulators-in-t2dm-men-during-cycling
#15
Christian Brinkmann, Alexander Metten, Philipp Scriba, Christos V M Tagarakis, Patrick Wahl, Jo Latsch, Klara Brixius, Wilhelm Bloch
Exercise-induced transient increases in pro-angiogenic regulators can promote angiogenesis.This pilot study aims to analyze the potential of exercise to positively affect angiogenic regulators in patients with type 2 diabetes mellitus (T2DM), who often exhibit abnormal angiogenesis, under different environmental conditions. 9 overweight/obese men with uncomplicated T2DM (8 took anti-diabetic drugs) performed submaximal cycling for 40 min in normoxia (≈21 vol%O2), hypoxia (≈14 vol%O2) and during alternating hypoxia/hyperoxia (≈14 vol%O2/≈30 vol%O2, 5-min intervals) (3×3 crossover design)...
February 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28053548/recombinant-human-endostatin-in-combination-with-chop-regimen-for-peripheral-t-cell-lymphoma
#16
Qunling Zhang, Junning Cao, Kai Xue, Xiaojian Liu, Dongmei Ji, Ye Guo, Xiaonan Hong
Peripheral T cell lymphoma (PTCL) has a poor prognosis. Overexpression of vascular endothelial growth factor (VEGF) might contribute to the poor prognosis of PTCL and could be the target of novel therapy. The efficacy and safety of recombinant human endostatin (Endostar) in combination with cyclophosphamide, doxorubicin, vincristine and prednisone (ECHOP) have been explored in 15 PTCL patients. The objective response rate was 80%, with 53.3% patients having achieved complete response (CR) rate. The CR rate was 100% (3/3) in angioimmunoblastic T cell lymphoma (AITL) patients compared to only 36...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27988246/identification-of-neuronal-and-angiogenic-growth-factors-in-an-in-vitro-blood-brain-barrier-model-system-relevance-in-barrier-integrity-and-tight-junction-formation-and-complexity
#17
Christian Freese, Sanshiro Hanada, Petra Fallier-Becker, C James Kirkpatrick, Ronald E Unger
We previously demonstrated that the co-cultivation of endothelial cells with neural cells resulted in an improved integrity of the in vitro blood-brain barrier (BBB), and that this model could be useful to evaluate the transport properties of potential central nervous system disease drugs through the microvascular brain endothelial. In this study we have used real-time PCR, fluorescent microscopy, protein arrays and enzyme-linked immunosorbent assays to determine which neural- and endothelial cell-derived factors are produced in the co-culture and improve the integrity of the BBB...
May 2017: Microvascular Research
https://www.readbyqxmd.com/read/27968915/dynamic-contrast-enhanced-mri-to-predict-response-to-vinorelbine-cisplatin-alone-or-with-rh-endostatin-in-patients-with-non-small-cell-lung-cancer-and-bone-metastases-a-randomised-double-blind-placebo-controlled-trial
#18
Rui Zhang, Zhi-Yu Wang, Yue-Hua Li, Yao-Hong Lu, Shuai Wang, Wen-Xi Yu, Hui Zhao
BACKGROUND: Metastatic bone disease is a frequent complication of advanced non-small-cell lung cancer and causes skeletal-related events which result in a poor prognosis. A standard method to assess the therapeutic response of bone metastases does not currently exist. We used dynamic contrast-enhanced MRI to obtain quantitative measures to assess the suitability of this technique to gauge therapeutic response to vinorelbine-cisplatin plus rh-endostatinfor previously untreated non-small cell lung cancer with bone metastases...
October 2016: Lancet
https://www.readbyqxmd.com/read/27956223/the-effect-of-cryopreservation-on-anti-cancer-activity-of-human-amniotic-membrane
#19
Khashayar Modaresifar, Sara Azizian, Maryam Zolghadr, Hamideh Moravvej, Abolhassan Ahmadiani, Hassan Niknejad
Human amniotic membrane (AM) is an appropriate candidate for treatment of cancer due to special properties, such as inhibition of angiogenesis and secretion of pro-apoptotic factors. This research was designed to evaluate the impact of cryopreservation on cancer cell death induction and anti-angiogenic properties of the AM. Cancer cells were treated with fresh and cryopreserved amniotic condition medium during 24 h and cancer cell viability was determined by MTT assay. To evaluate angiogenesis, the rat aorta ring assay was performed for both fresh and cryopreserved AM within 7 days...
December 9, 2016: Cryobiology
https://www.readbyqxmd.com/read/27930387/noninvasive-estimation-of-liver-fibrosis-in-biopsy-proven-hepatitis-c-virus-infected-patients-angiogenic-fibrogenic-link
#20
El-Shahat A Toson, Gamal E Shiha, Hatem A El-Mezayen, Waleed Samir, Mohamed M El-Khininy
BACKGROUND/AIM: The assessment of liver fibrosis provides useful information not only for diagnosis but also for therapeutic decisions. This study aimed to develop and evaluate a predictive score named the angiogenic index (Angio-Index) for liver fibrosis staging and to compare Angio-Index by King, Gotebörg University Cirrhosis Index, Lok, FIB-4, and aspartate aminotranferase/alanine aminotranferase scores in hepatitis C virus-infected patients. PATIENTS AND METHODS: Serum levels of angiopoietin-2, basic fibroblast growth factor, hepatocyte growth factor, and endostatin were assayed using an enzyme-linked immunosorbent assay in 122 HCV patients represented in two sets (estimation group and validation group)...
February 2017: European Journal of Gastroenterology & Hepatology
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