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https://www.readbyqxmd.com/read/27897101/platelets-from-glioblastoma-patients-promote-angiogenesis-of-tumor-endothelial-cells-and-exhibit-increased-vegf-content-and-release
#1
Clara Di Vito, Stefania Elena Navone, Giovanni Marfia, Loubna Abdel Hadi, Maria Elisa Mancuso, Alessandro Pecci, Francesco Maria Crisà, Valeria Berno, Paolo Rampini, Rolando Campanella, Laura Riboni
Glioblastoma multiforme (GBM) is the most common and fatal intracranial cancer in humans and exhibits intense and aberrant angiogenesis that sustains its malignancy and involves several angiogenic signals. Among them, vascular endothelial growth factor (VEGF) plays a key role and is overexpressed in GBM. Different cells appear to act as triggers of the aberrant angiogenesis, and, among them, platelets act as key participants. In order to provide further insights into the platelet features and angiogenic role in GBM, this study investigated the effects of platelet releasate on GBM-derived endothelial cells (GECs) and the levels of VEGF and endostatin, as pro- and anti-angiogenic components of platelet releasate from GBM patients...
November 29, 2016: Platelets
https://www.readbyqxmd.com/read/27890369/anti-tumor-activity-of-tanshinone-iia-in-combined-with-cyclophosphamide-against-lewis-mice-with-lung-cancer
#2
Qi Li, Ke Hu, Si Tang, Li-Fang Xu, Yu-Chuan Luo
OBJECTIVE: To explore the anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer and the effect on cellular immune function. METHODS: Lewis tumor cells were inoculated subcutaneously into the right armpit of mice in each group (n = 20) to establish Lewis lung cancer mice model. After model establishment, mice in the model group were given normal saline by lavage, qd. Mice in treatment I group were given intraperitoneal injection of Tan IIA, 15 mg/kg, qd...
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27888623/recombined-humanized-endostatin-endostar-combined-with-chemotherapy-for-advanced-bone-and-soft-tissue-sarcomas-in-stage-iv
#3
Peipei Xing, Jin Zhang, Zhao Yan, Gang Zhao, Xubin Li, Guowen Wang, Yun Yang, Jun Zhao, Ruwei Xing, Sheng Teng, Yulin Ma, Zhichao Liao, Zhiwu Ren, Chao Zhang, Xiuxin Han, Wei Zhang, Kexin Chen, Ping Wang, Jilong Yang
PURPOSE: This retrospective case-series study evaluated efficacy and safety of Endostar combined with chemotherapy in the treatment of advanced bone and soft tissue sarcomas in stage IV. MATERIALS AND METHODS: Forty-seven patients diagnosed with stage IV bone and soft tissue sarcomas and treated with chemotherapy in Tianjin Medical University Cancer Institute & Hospital were reviewed. Of these patients, 23 patients were treated with Endostar plus chemotherapy (designated as combined group), and 24 patients received only chemotherapy (designated as control group)...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27881337/-inhibitory-effect-of-mig-7-silencing-by-retrovirus-mediated-shrna-on-vasculogenic-mimicry-invasion-and-metastasis-of-human-hepatocellular-carcinoma-cells-in-vitro
#4
Bo Qu, Guan-Nan Sheng, Fei Yu, Guan-Nan Chen, Qi Lv, Zhong-Peng Mao, Long Guo, Yi Lv
OBJECTIVE: To explore the inhibitory effect of migration-inducing gene 7 (Mig-7) gene silencing induced by retroviral-mediated small hairpin RNA (shRNA) on vasculogenic mimicry (VM), invasion and metastasis of human hepatocellular carcinoma (HCC) cells in vitro. METHODS: Two target sequences (Mig-7 shRNA-1 and Mig-7 shRNA-2) and one negative control sequence (Mig-7 shRNA-N) were synthesized. The recombinant retroviral vectors carrying Mig-7 shRNA were constructed, and HCC cell line MHCC-97H were transfected with Mig-7 shRNA-1, Mig-7 shRNA-2, Mig-7 shRNA-N, or the empty vector, or treated with 125 µg/mL recombinant human endostatin (ES)...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27858860/antagonistic-effects-of-endostatin-vascular-endothelial-growth-inhibitor-chimeric-recombinant-adenovirus-on-homocysteine-induced-vascular-endothelial-cells-injury-in-vitro-and-in-vivo
#5
Zhen-Tian Cui, Jian-Ping Liu, Jian-Min Yao
BACKGROUND: The study is inclined to investigate the antagonistic effects of endostatin-vascular endothelial growth inhibitor chimeric recombinant adenovirus (Ad-hENDO-VEGI) on homocysteine (Hcy)-induced vascular endothelial cells (VECs) injury in vitro and in vivo. METHODS: Human VECs cell line ECV304 was selected and infected with Ad-hENDO-VEGI. The LDH leakage, SOD activity, and MDA levels were measured by the automatic biochemical analyzer. Cell survival rate was counted by Trypanblau dying...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27842514/thoracic-perfusion-of-recombinant-human-endostatin-endostar-combined-with-chemotherapeutic-agents-versus-chemotherapeutic-agents-alone-for-treating-malignant-pleural-effusions-a-systematic-evaluation-and-meta-analysis
#6
Rong Biaoxue, Cai Xiguang, Liu Hua, Gao Wenlong, Yang Shuanying
BACKGROUND: Endostar is a new endogenous angiogenic inhibitor with implicated anti-tumor activity. This study was to investigate whether thoracic perfusion of Endostar could be used to control malignant pleural effusions (MPE). METHODS: We searched the databases of MEDLINE, Web of Science, EMBASE, Goggle, Cochrance Library and CNKI to select the studies regarding the efficacy of Endostar to treat MPE. A total of 13 randomised controlled trials (RCTs) with 1066 patients were included...
November 14, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27826199/effect-of-vegf-c-sirna-and-endostatin-on-ring-formation-and-proliferation-of-esophageal-squamous-cell-carcinoma-lymphatic-endothelial-cells
#7
Yuping Zheng, Miaomiao Sun, Jinyan Chen, Lulu He, Na Zhao, Kuisheng Chen
OBJECTIVE: To study the effects of vascular endothelial growth factor C small interfering RNA and endostatin on esophageal squamous cell carcinoma-related ring formation in vitro and proliferation of lymphatic endothelial cells. MATERIALS AND METHODS: KYSE150 cells were subjected to analysis of cell transfection and endostatin operation. The groups were as follows: negative group, blank group, negative plus endostatin group, endostatin group, SG1 group, SG2 group, SG1 plus endostatin group, and SG2 plus endostatin group...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27822063/the-accumulation-of-macrophages-attenuates-the-effect-of-recombinant-human-endostatin-on-lung-cancer
#8
Yanyang Liu, Li Tu, Li Wang, Jianlin Long, Jiantao Wang, Yuyi Wang, Feng Luo, Dan Cao
BACKGROUND: Although anti-angiogenic therapy is widely applied clinically, its efficacy has been less than expected. Screening for regulatory factors and sensitive indicators to define the effectiveness of these drugs is required. Through a retrospective study of clinical data, we found that patients with a higher peripheral monocyte-to-lymphocyte ratio (MLR) obtained less benefit from recombinant human endostatin (rhES, Endostar(®)), an anti-angiogenic drug, in lung cancer. Because MLR is positively correlated with macrophage count in tumors, this result suggests that macrophages may influence the effectiveness of rhES therapy in lung cancer...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27821588/smooth-muscle-cell-pro-angiogenic-phenotype-induced-by-cyclopentenyl-cytosine-promotes-endothelial-cell-proliferation-and-migration
#9
Rui Tang, Gui Zhang, Shi-You Chen
Vascular smooth muscle cells (SMCs) and endothelial cells (ECs) have a close contact with the blood vessel. SMC phenotypes can be altered during pathological vascular remodeling. However, how SMC phenotypes affect EC properties remain largely unknown. In the present study, we found that platelet-derived growth factor (PDGF)-BB-induced synthetic SMC suppressed EC proliferation and migration while exhibiting an increased expression of anti-angiogenic factors such as endostatin and decreased pro-angiogenic factors including C-X-C motif ligand 1 (CXCL1)...
November 7, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27800134/effect-of-culture-condition-variables-on-human-endostatin-gene-expression-in-escherichia-coli-using-response-surface-methodology
#10
Abbas Mohajeri, Yones Pilehvar-Soltanahmadi, Jalal Abdolalizadeh, Pouran Karimi, Nosratollah Zarghami
BACKGROUND: Recombinant human endostatin (rhES) is an angiogenesis inhibitor used as a specific drug for the treatment of non-small-cell lung cancer. As mRNA concentration affects the recombinant protein expression level, any factor affecting mRNA concentration can alter the protein expression level. Response surface methodology (RSM) based on the Box-Behnken design (BBD) is a statistical tool for experimental design and for optimizing biotechnological processes. OBJECTIVES: This investigation aimed to predict and develop the optimal culture conditions for mRNA expression of the synthetic human endostatin (hES) gene in Escherichia coli BL21 (DE3)...
August 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27788725/-inhibitory-effect-of-migration-inducing-gene-7-shrna-recombinant-retrovirus-combined-with-endostatin-on-growth-and-metastasis-of-hepatoma-xenograft
#11
B Qu, G N Chen, G N Sheng, F Yu, Q Lyu, Y J Gu, L Guo, Y Lyu
Objective: To investigate the inhibitory effect of migration-inducing gene-7(Mig-7)interfered with retrovirus-mediated RNA(shRNA)combined with recombinant human endostatin(ES)on the growth and metastasis of subcutaneous xenograft of human hepatoma cells in nude mice. Methods: Two Mig-7-mRNA oligonucleotide sequences(Mig-7-shRNA-1 and Mig-7-shRNA-2)and one sequence as a negative control(Mig-7-shRNA-N)were designed. The specific Mig-7-shRNA recombinant retrovirus expression vector plasmid was constructed and used for the transfection of human hepatoma MHCC-97H cells with high expression of Mig-7...
September 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27760596/-recombinant-human-endostatin-in-the-treatment-of-advanced-lung-squamous-cell-carcinoma
#12
Puyuan Xing, Xuezhi Hao, Xingsheng Hu, Yan Wang, Junling Li
BACKGROUND: Squamous cell carcinoma (SCC) is a common pathological type of non-small cell lung cancer, and advanced lung SCC is incurable. Chemotherapy combined with anti-angiogenesis agents can prolong the patients' survival time. The aim of the study was to analyze the efficacy and safety of recombinant human endostatin (Endostar) in treating advanced lung SCC. METHODS: We retrospectively analyzed the short-term efficacy and toxicity of recombinant human endostatin combined with traditional chemotherapy regimens in treating 15 advanced lung squamous cell carcinoma patients in Department of Medical Oncology retrospectively, Cancer Hospital, Chinese Academy of Medical Sciences from November 2011 to May 2015...
October 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27758098/gold-nanoparticle-reprograms-pancreatic-tumor-microenvironment-and-inhibits-tumor-growth
#13
Sounik Saha, Xunhao Xiong, Prabir K Chakraborty, Khader Shameer, Rochelle R Arvizo, Rachel A Kudgus, Shailendra Kumar Dhar Dwivedi, Md Nazir Hossen, Elizabeth M Gillies, J David Robertson, Joel T Dudley, Raul A Urrutia, Russell G Postier, Resham Bhattacharya, Priyabrata Mukherjee
Altered tumor microenvironment (TME) arising from a bidirectional crosstalk between the pancreatic cancer cells (PCCs) and the pancreatic stellate cells (PSCs) is implicated in the dismal prognosis in pancreatic ductal adenocarcinoma (PDAC), yet effective strategies to disrupt the crosstalk is lacking. Here, we demonstrate that gold nanoparticles (AuNPs) inhibit proliferation and migration of both PCCs and PSCs by disrupting the bidirectional communication via alteration of the cell secretome. Analyzing the key proteins identified from a functional network of AuNP-altered secretome in PCCs and PSCs, we demonstrate that AuNPs impair secretions of major hub node proteins in both cell types and transform activated PSCs toward a lipid-rich quiescent phenotype...
October 19, 2016: ACS Nano
https://www.readbyqxmd.com/read/27750216/filamin-a-interacting-protein-1-like-expression-inhibits-progression-in-colorectal-cancer
#14
Young-Lan Park, Sun-Young Park, Seung-Hyun Lee, Rul-Bin Kim, Joong-Keun Kim, Sung-Yoon Rew, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Hyun-Soo Kim, Young-Eun Joo
Filamin A interacting protein 1-like (FILIP1L) expression, which is decreased in various cancers, may inhibit carcinogenesis. In this study, we evaluated the effects of FILIP1L on oncogenic behavior and prognosis in colorectal cancer. siRNA-mediated FILIP1L knockdown enhanced tumor cell migration and invasion and inhibited apoptosis and cell cycle arrest in COLO205 cells. pcDNA-myc vector-mediated FILIP1L overexpression suppressed tumor cell migration and invasion and induced apoptosis and cell cycle arrest in HCT116 cells...
October 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27746220/collagen-xviii-in-tissue-homeostasis-and-dysregulation-lessons-learned-from-model-organisms-and-human-patients
#15
Ritva Heljasvaara, Mari Aikio, Heli Ruotsalainen, Taina Pihlajaniemi
Collagen XVIII is a ubiquitous basement membrane (BM) proteoglycan produced in three tissue-specific isoforms that differ in their N-terminal non-collagenous sequences, but share collagenous and C-terminal non-collagenous domains. The collagenous domain provides flexibility to the large collagen XVIII molecules on account of multiple interruptions in collagenous sequences. Each isoform has a complex multi-domain structure that endows it with an ability to perform various biological functions. The long isoform contains a frizzled-like (Fz) domain with Wnt-inhibiting activity and a unique domain of unknown function (DUF959), which is also present in the medium isoform...
October 13, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27730697/recombinant-human-endostatin-inhibits-tnf-alpha-induced-receptor-activator-of-nf-%C3%AE%C2%BAb-ligand-expression-in-fibroblast-like-synoviocytes-in-mice-with-adjuvant-arthritis
#16
Qiu-Fang Gao, Xiu-Hong Zhang, Feng-Lai Yuan, Ming-Dong Zhao, Xia Li
Bone loss is a critical pathology responsible for the functional disability in patients with rheumatoid arthritis (RA). It is well known that receptor activator of nuclear factor kappa-B (NF-κB) ligand (RANKL) plays a crucial role in bone loss in RA. The purpose of this study was to determine whether recombinant human endostatin (rh-endostatin) mediates bone erosion in RA by regulation of RANKL expression in an experimental model of RA, consisting of mice with adjuvant-induced arthritis (AA). Cultured AA fibroblast-like synoviocytes (FLSs) obtained from these mice were induced by tumor necrosis factor-α (TNF-α) combined with or without rh-endostatin...
October 12, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27710144/lentiviral-vector-gene-transfer-of-endostatin-angiostatin-for-macular-degeneration-gem-study
#17
Peter A Campochiaro, Andreas K Lauer, Elliott H Sohn, Tahreem A Mir, Stuart Naylor, Matthew C Anderton, Michelle Kelleher, Richard Harrop, Scott Ellis, Kyriacos A Mitrophanous
Neovascular age-related macular degeneration (NVAMD) is a prevalent cause of vision loss. Intraocular injections of VEGF-neutralizing proteins provide benefit, but many patients require frequent injections for a prolonged period. Benefits are often lost over time due to lapses in treatment. New treatments that sustain anti-angiogenic activity are needed. This study tested the safety and expression profile of a lentiviral Equine Infectious Anemia Virus (EIAV) vector expressing endostatin and angiostatin (RetinoStat(®))...
September 26, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27703219/antiangiogenic-therapy-using-endostatin-increases-the-number-of-aldh-lung-cancer-stem-cells-by-generating-intratumor-hypoxia
#18
Yang Yu, Yu-Yi Wang, Yi-Qin Wang, Xia Wang, Yan-Yang Liu, Jian-Tao Wang, Chi Du, Li Wang, Mei Li, Feng Luo, Ming Jiang
Antiangiogenic therapy is becoming a promising option for cancer treatment. However, many investigations have recently indicated that these therapies may have limited efficacy, and the cancers in most patients eventually develop resistance to these therapies. There is considerable recently acquired evidence for an association of such resistance with cancer stem-like cells (CSLCs). Here, we used xenograft tumor murine models to further suggest that antiangiogenic agents actually increase the invasive and metastatic properties of lung cancer cells...
October 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27693124/inhibitory-effect-of-recombinant-human-endostatin-on-the-proliferation-of-hypertrophic-scar-fibroblasts-in-a-rabbit-ear-model
#19
Yong-Fang Gong, Xiao-Ming Zhang, Fei Liu, Zhen-Zhen Wang, Xue-Fei Deng, Yi Jiao, Xiao-Jing Li, Xue-Ying Huang
Hypertrophic scar (HS) is a pathological scar that particularly occurs after traumatic injuries, surgical procedures and burning. Abnormal activation of hypertrophic scar fibroblasts (HSFs) intensifies fibrosis during wound healing. Our previous studies demonstrated that recombinant human endostatin (rhEndostatin) prevented synovial thickening in adjuvant arthritis (AA) rats via inhibition of proliferation and enhancement of apoptosis in synovial fibroblasts. However, the effect of this protein on HSF proliferation is not known...
September 28, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27693049/the-antiangiogenic-and-antitumor-activities-of-the-n-terminal-fragment-of-endostatin-augmented-by-ile-arg-substitution-the-overall-structure-implicated-the-biological-activity
#20
Reyhane Chamani, S Mohsen Asghari, Ali Mohammad Alizadeh, Kamran Mansouri, Taher Doroudi, Peir Hossein Kolivand, Hossein Ghafouri, Somayeh Ehtesham, Hanieh Rabouti, Faramarz Mehrnejad
The antiangiogenic and antitumor activities of the 27-amino acid fragment corresponding to the N-terminal domain of endostatin were shown to be dependent on a Zn-binding loop in the N-terminus. To investigate whether the regions outside of the N-terminal loop play a role in the peptide function, the structure and function of a variant containing Ile26Arg mutation (ES-R) were compared with those of the native peptide (ES-Zn). Structural analysis using far-UV CD, intrinsic fluorescence and molecular dynamics simulation provided information regarding the overall changes upon the mutation...
December 2016: Biochimica et Biophysica Acta
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