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https://www.readbyqxmd.com/read/29436895/a-model-to-study-complement-involvement-in-experimental-retinal-degeneration
#1
Camilla Mohlin, Kerstin Sandholm, Anders Kvanta, Kristina N Ekdahl, Kjell Johansson
BACKGROUND: The complement system (CS) plays a role in the pathogenesis of a number of ocular diseases, including diabetic retinopathy (DR), glaucoma, uveitis, and age-related macular degeneration (AMD). Given that many of the complex eye-related degenerative diseases have limited treatment opportunities, we aimed to mimic the in vivo retinal degenerative process by developing a relevant co-culture system. METHOD AND MATERIALS: The adult porcine retina was co-cultured with the spontaneously arising human retinal pigment epithelial cells-19 (ARPE-19)...
February 13, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/29429764/safety-and-efficacy-of-adalimumab-in-patients-with-noninfectious-uveitis-in-an-ongoing-open-label-study-visual-iii
#2
Eric B Suhler, Alfredo Adán, Antoine P Brézin, Eric Fortin, Hiroshi Goto, Glenn J Jaffe, Toshikatsu Kaburaki, Michal Kramer, Lyndell L Lim, Cristina Muccioli, Quan Dong Nguyen, Joachim Van Calster, Luca Cimino, Martina Kron, Alexandra P Song, Jianzhong Liu, Sophia Pathai, Anne Camez, Ariel Schlaen, Mirjam E J van Velthoven, Albert T Vitale, Manfred Zierhut, Samir Tari, Andrew D Dick
PURPOSE: To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis. DESIGN: Phase 3, open-label, multicenter clinical trial extension (VISUAL III). PARTICIPANTS: Adults meeting treatment failure (TF) criteria or who completed VISUAL I or II (phase 3, randomized, double-masked, placebo-controlled) without TF. METHODS: Patients received adalimumab 40 mg every other week...
February 8, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29396390/diagnostic-function-of-3d-optical-coherence-tomography-images-in-diagnosis-of-vogt-koyanagi-harada-disease-at-acute-uveitis-stage
#3
Gui-Ling Zhao, Rui-Zhuang Li, Yan-Hua Pang, Xiu-Qin Wang, Hong-Juan Peng, Jin-Fen Wei, Zhou Zhou
BACKGROUND This study analyzed the macular 3D-OCT images of Vogt-Koyanagi-Harada disease (VKH) in uveitis, explored the characteristics of 3D-OCT images of the macular region of VKH, and assessed which characteristics contribute most to VKH diagnosis. MATERIAL AND METHODS The 3D-OCT examination of 25 cases of VKH was performed on the macular area, and the image characteristics were analyzed. RESULTS Our study included a total of 50 eyes from 25 cases of VKH patients, 10 males and 15 females, aged 17 to 64 years, mean (39...
February 3, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29371007/efficacy-and-safety-of-ranibizumab-0-5-mg-for-the-treatment-of-macular-edema-resulting-from-uncommon-causes-twelve-month-findings-from-prometheus
#4
Giovanni Staurenghi, Timothy Y Y Lai, Paul Mitchell, Sebastian Wolf, Andreas Wenzel, Jun Li, Amitabha Bhaumik, Philip G Hykin
PURPOSE: To evaluate the efficacy and safety of ranibizumab 0.5 mg in adult patients with macular edema (ME) resulting from any cause other than diabetes, retinal vein occlusion, or neovascular age-related macular degeneration. DESIGN: A phase 3, 12-month, double-masked, randomized, sham-controlled, multicenter study. PARTICIPANTS: One hundred seventy-eight eligible patients aged ≥18 years. METHODS: Patients were randomized 2:1 to receive either ranibizumab 0...
January 19, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29323215/green-tea-extract-attenuates-lps-induced-retinal-inflammation-in-rats
#5
Jia Lin Ren, Qiu Xiao Yu, Wei Cheng Liang, Pui Ying Leung, Tsz Kin Ng, Wai Kit Chu, Chi Pui Pang, Sun On Chan
Inflammation is in a wide spectrum of retinal diseases, causing irreversible blindness and visual impairment. We have previously demonstrated that Green Tea Extract (GTE) is a potent anti-inflammatory agent for anterior uveitis. Here we investigated the anti-inflammatory effect of GTE on lipopolysaccharides (LPS)-induced retinal inflammation in rats and explored the underlying mechanism. Adult rats were injected with LPS and GTE was administered intra-gastrically at 2, 8, 26 and 32 hours post-injection. Staining of whole-mount retina showed that the number of activated microglia cells was significantly increased at 48 hours post-injection, which was suppressed after GTE treatment in a dose-dependent manner...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317400/two-year-outcomes-of-intravitreal-ziv-aflibercept
#6
Ahmad M Mansour, Mohammed Ashraf, Abdulrazzak Charbaji, Muhammad H Younis, Ahmed A Souka, Avantika Dogra, Hana A Mansour, Jay Chhablani
AIM: To assess the two-year outcome of intravitreal ziv-aflibercept (IVZ) in eyes with macular diseases. METHODS: Consecutive subjects with various macular diseases that received six or more of 0.05 mL IVZ (1.25 mg) injections with at least 1 year follow-up were included. Outcome measures were best-corrected visual acuity (BCVA) (logarithm of the minimum angle of resolution) and central macular thickness (CMT) on spectral domain optical coherence tomography...
January 9, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29308276/beh%C3%A3-et-s-disease-in-the-united-states-a-single-center-descriptive-and-comparative-study
#7
Nathan C Kilian, Amr H Sawalha
Objective: Behçet's disease is heterogeneous with clinical variability across ethnicities and geographic locations. The goal of this study was to analyze the clinical characteristics of our multi-ethnic Behçet's disease cohort at the University of Michigan. Material and Methods: A detailed patient characterization was performed. Differences in disease characteristics between men and women, and between patients fulfilling the International Criteria for Behçet's Disease (ICBD) and the International Study Group criteria (ISG) were determined in our cohort...
December 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29300249/pigmented-paravenous-chorioretinal-atrophy-detailed-clinical-study-of-a-large-cohort
#8
Olajumoke A Shona, Farrah Islam, Anthony G Robson, Andrew R Webster, Anthony T Moore, Michel Michaelides
PURPOSE: To review and describe in detail the demographics, functional and anatomical characteristics, and clinical course of pigmented paravenous chorioretinal atrophy in a large cohort of adults and children. METHODS: This is a retrospective case series of consecutive patients diagnosed with pigmented paravenous chorioretinal atrophy at a single U.K. referral center from 1974 to 2016. Clinical records, retinal imaging (color fundus photography, fundus autofluorescence, and optical coherence tomography), and electrophysiological assessments were reviewed...
January 3, 2018: Retina
https://www.readbyqxmd.com/read/29229445/optical-coherence-tomography-angiography
#9
REVIEW
Richard F Spaide, James G Fujimoto, Nadia K Waheed, Srinivas R Sadda, Giovanni Staurenghi
Optical coherence tomography (OCT) was one of the biggest advances in ophthalmic imaging. Building on that platform, OCT angiography (OCTA) provides depth resolved images of blood flow in the retina and choroid with levels of detailed far exceeding that obtained with older forms of imaging. This new modality is challenging because of the need for new equipment and processing techniques, current limitations of imaging capability, and rapid advancements in both imaging and in our understanding of the imaging and applicable pathophysiology of the retina and choroid, and the requirement for understanding the origins of image artifacts...
December 8, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29200130/diffuse-retinal-vascular-leakage-and-cone-rod-dystrophy-in-a-family-with-the-homozygous-missense-c-1429g-a-p-gly477arg-mutation-in-crb1
#10
Hamed Al Sulaiman, Patrik Schatz, Sawsan R Nowilaty, Ehab Abdelkader, Leen Abu Safieh
PURPOSE: To describe a specific cone-rod dystrophy phenotype in a family with the homozygous c.1429G>A; p.Gly477Arg mutation in CRB1. The detailed phenotype of subjects with this specific mutation has not been described previously. METHODS: Clinical examination included full-field electroretinography and high-resolution and widefield retinal imaging and uveitis workup. Molecular genetic analysis included next-generation sequencing of known retinal dystrophy genes and Sanger sequencing for segregation analysis...
December 1, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29176536/paracentral-acute-middle-maculopathy-associated-with-bilateral-optic-disk-swelling-and-meningitis
#11
Zhenyang Zhao, Parker Faith, Kaivon Pakzad-Vaezi, Zhongdi Chu, Ruikang K Wang, Raghu C Mudumbai, Kasra A Rezaei
BACKGROUND/PURPOSE: To present a novel case of paracentral acute middle maculopathy associated with bilateral optic disk swelling. METHODS: Retrospective case report. RESULTS: A 67-year-old woman presented with sudden onset of central vision loss and subsequent bilateral optic disk edema, retinal vessel attenuation, and anterior uveitis. Cerebrospinal fluid analysis showed signs of inflammation. Spectral domain optical coherence tomography demonstrated the pathognomonic hyperreflectivity of the middle retinal layers consistent with paracentral acute middle maculopathy...
November 22, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29172842/review-for-disease-of-the-year-clinic-of-cytomegalovirus-induced-anterior-uveitis
#12
Nicole Shu-Wen Chan, Soon-Phaik Chee, Laure Caspers, Bahram Bodaghi
Cytomegalovirus (CMV) anterior uveitis is the most common ocular manifestation of CMV disease in immunocompetent individuals. It is thought to be due to a local reactivation of latent CMV and is usually unilateral. The acute form presents as Posner-Schlossman Syndrome, a recurrent hypertensive anterior uveitis with few granulomatous keratic precipitates. There are geographic differences in the chronic form of CMV anterior uveitis. Asian patients commonly present as Fuchs Uveitis Syndrome with diffuse stellate keratic precipitates, while the European patients present with a chronic hypertensive anterior uveitis with fewer keratic precipitates that are brown in color and located inferiorly...
November 27, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29170182/panuveitis-simulating-ocular-beh%C3%A3-et-s-in-cases-of-chronic-myelogenous-leukaemia-in-remission
#13
Rohan Chawla, Koushik Tripathy
We report two patients with chronic myelogenous leukaemia (CML) in remission phase who developed panuveitis simulating Behçet's disease. A 26-year-old man presented with bilateral panuveitis (hypopyon in the right eye, bilateral anterior segment inflammation, vitritis and retinitis). He was on imatinib for CML which was in remission. He gave a history of recurrent oral ulcers. The panuveitis responded to oral and topical steroids but recurred after the steroids were stopped. His ocular condition again stabilised on restarting oral steroids and azathioprine...
November 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#14
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29122311/-uveitis-diagnostic-work-up-recommendations-from-an-expert-committee
#15
P Sève, B Bodaghi, S Trad, J Sellam, D Bellocq, P Bielefeld, D Sène, G Kaplanski, D Monnet, A Brézin, M Weber, D Saadoun, P Cacoub, C Chiquet, L Kodjikian
INTRODUCTION: Diagnostic work-up of uveitis involves many uncertainties. Search for an etiology should take into account the epidemiology of uveitis and focus on the most severe diseases or those, which can be treated. This work was undertaken to establish recommendations for the diagnosis work-up of uveitis. METHODS: Recommendations were developed by a multidisciplinary panel of 15 experts, including internists, ophthalmologists and a rheumatologist and are based on a review of the literature with regard to effectiveness of investigations and the results of the ULISSE study, which is the first prospective study assessing the efficiency of a standardized strategy for the etiological diagnosis of uveitis...
November 6, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29103560/equine-glaucoma
#16
REVIEW
Tammy Miller Michau
Glaucoma is a multifactorial neurodegenerative ocular disease leading to progressive loss of retinal ganglion cells and their axons that form the optic nerve, causing blindness. Knowledge of the pathogenesis and development of equine glaucoma is in its infancy compared with human glaucoma. Glaucoma occurs most commonly secondary to uveitis and may be underdiagnosed or misdiagnosed in horses suffering from uveitis. Recognition and clinical diagnosis of glaucoma in the horse is improved with clinician awareness and the availability of handheld tonometers...
December 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/29084331/the-anti-inflammatory-effect-of-ripasudil-k-115-a-rho-kinase-rock-inhibitor-on-endotoxin-induced-uveitis-in-rats
#17
Takatoshi Uchida, Megumi Honjo, Reiko Yamagishi, Makoto Aihara
Purpose: To investigate the anti-inflammatory properties of ripasudil, a Rho kinase (ROCK) inhibitor, using endotoxin-induced uveitis (EIU) in rats. Methods: Endotoxin-induced uveitis was induced by footpad injection of lipopolysaccharide (LPS). Ripasudil was administered intraperitoneally 1 hour before and after LPS injection. The aqueous humor was collected 24 hours after injection, and the infiltrating cells, protein concentration, and levels of monocyte chemotactic protein-1 (MCP-1) were determined...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29079770/ocular-antigen-does-not-cause-disease-unless-presented-in-the-context-of-inflammation
#18
Valentina Voigt, Matthew E Wikstrom, Jelena M Kezic, Iona S Schuster, Peter Fleming, Kimmo Makinen, Stephen R Daley, Christopher E Andoniou, Mariapia A Degli-Esposti, John V Forrester
Ocular antigens are sequestered behind the blood-retina barrier and the ocular environment protects ocular tissues from autoimmune attack. The signals required to activate autoreactive T cells and allow them to cause disease in the eye remain in part unclear. In particular, the consequences of peripheral presentation of ocular antigens are not fully understood. We examined peripheral expression and presentation of ocular neo-self-antigen in transgenic mice expressing hen egg lysozyme (HEL) under a retina-specific promoter...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29068389/clinical-effect-of-irt-5-probiotics-on-immune-modulation-of-autoimmunity-or-alloimmunity-in-the-eye
#19
Jaeyoung Kim, Se Hyun Choi, Yu Jeong Kim, Hyun Jeong Jeong, Jin Suk Ryu, Hyun Ju Lee, Tae Wan Kim, Sin-Hyeog Im, Joo Youn Oh, Mee Kum Kim
BACKGROUND: Although the relation of the gut microbiota to a development of autoimmune and inflammatory diseases has been investigated in various animal models, there are limited studies that evaluate the effect of probiotics in the autoimmune eye disease. Therefore, we aimed to investigate the effect of IRT-5 probiotics consisting of Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus reuteri, Bifidobacterium bifidum, and Streptococcus thermophilus on the autoimmunity of uveitis and dry eye and alloimmunity of corneal transplantation...
October 25, 2017: Nutrients
https://www.readbyqxmd.com/read/29057162/augmenting-endogenous-levels-of-retinal-annexin-a1-suppresses-uveitis-in-mice
#20
Peter J Gardner, Samia Yazid, Joana Ribeiro, Robin R Ali, Andrew D Dick
PURPOSE: The purpose of this study was to examine the expression of the anti-inflammatory protein Annexin A1 (AnxA1) in mice and human retinae during uveitis and to determine whether local administration of human recombinant AnxA1 (hrAnxA1) can suppress uveitis in mice. METHODS: Retinal sections from mice (healthy normal and uveitis) and postmortem human (no history of eye disease (n = 5) and uveitis (n = 7)) were stained for AnxA1 expression and imaged by immunofluorescence microscopy...
September 2017: Translational Vision Science & Technology
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