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Uveitis, retinal diseases

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https://www.readbyqxmd.com/read/28820347/association-between-eye-diagnosis-and-positive-syphilis-test-results-in-a-large-urban-sexually-transmitted-infection-primary-care-clinic-population
#1
Ann-Marie Lobo, Yan Gao, Laura Rusie, Magda Houlberg, Supriya D Mehta
In 2015, the Centers for Disease Control and Prevention (CDC) and the American Academy of Ophthalmology (AAO) released clinical advisories on rising cases of ocular syphilis. We examined the association between eye disease and syphilis infection among primary care and sexually transmitted infection (STI) clinic patients attending an urban lesbian, gay, bisexual, transgender (LGBT) health center. We conducted a retrospective medical record review of all patients who underwent syphilis testing at Howard Brown Health between 1 January 2010 and 31 December 2015...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28816862/unilateral-optic-neuritis-and-central-retinal-vasculitis-due-to-ocular-syphilis
#2
Murtaza S Khan, Dulanji K Kuruppu, Tanav A Popli, Ramana S Moorthy, Devin D Mackay
PURPOSE: Report a case of concurrent unilateral optic neuritis and central retinal artery occlusion as the presenting signs of syphilis. METHODS: A case report of a 22-year-old man with progressive unilateral vision loss. RESULTS: With no known previous history of syphilis, genital lesions, or other extraocular manifestations, the patient presented with pain with eye movements and decreased color vision. His vision dramatically worsened after a course of oral steroids...
August 14, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28799185/punctate-retinal-hemorrhage-and-its-relation-to-ocular-and-systemic-disease-in-dogs-83-cases
#3
Nathaniel P Violette, Eric C Ledbetter
OBJECTIVE: To describe clinical aspects of dogs with punctate retinal hemorrhage (PRH). ANIMALS STUDIED: 83 dogs (119 eyes) with PRH. PROCEDURES: Medical records of dogs evaluated by the Cornell University ophthalmology service with a clinical diagnosis of PRH between 2006 and 2015 were reviewed. For this study, PRH was defined as retinal hemorrhages ≤ 1 optic disk diameter in size and dogs with other posterior segment ocular diseases were excluded...
August 10, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28782485/a-low-concentration-of-tacrolimus-semifluorinated-alkane-sfa-eyedrop-suppresses-intraocular-inflammation-in-experimental-models-of-uveitis
#4
S De Majumdar, M Subinya, J Korward, A Pettigrew, D Scherer, H Xu
PURPOSE: Corticosteroids remain the mainstay therapy for uveitis, a major cause of blindness in the working age population. However, a substantial number of patients cannot benefit from the therapy due to steroids resistance or intolerance. Tacrolimus has been used to treat refractory uveitis through systemic administration. The aim of this study was to evaluate the therapeutic potential of 0.03% tacrolimus eyedrop in mouse models of uveitis. METHODS: 0.03% tacrolimus in perfluorobutylpentane (F4H5) (0...
August 7, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28782234/causes-and-outcomes-of-dogs-presenting-with-hyphema-to-a-referral-hospital-in-colorado-a-retrospective-analysis-of-99-cases
#5
Maggie R Jinks, Francisco Olea-Popelka, Kate S Freeman
OBJECTIVE: To investigate the causes of hyphema in dogs and identify factors associated with poor visual outcomes. ANIMALS STUDIED: Ninety-nine dogs (120 eyes) that presented with hyphema. PROCEDURE: Medical records from the Colorado State University Veterinary Teaching Hospital between the years 2004-2015 were reviewed. RESULTS: Overall, 36.4% of dogs were diagnosed with hyphema from systemic causes, 32.9% due to local ocular disease, 26...
August 6, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28776596/ocular-syphilis-the-re-establishment-of-an-old-disease
#6
J Wells, C Wood, A Sukthankar, N P Jones
PurposeTo present the patient profiles, clinical presentations and visual outcomes in those diagnosed with ocular syphilis, attending a subspecialist uveitis service in northern England over a 15-year period.Patients and methodsRetrospective observational case series of patients presenting between January 2002 and December 2016.ResultsA total of 50 eyes of 34 patients had intraocular inflammation due to syphilis. Of these, 94% were male, and 75% were men who had sex with men. Ten (29%), all male, were HIV-positive...
August 4, 2017: Eye
https://www.readbyqxmd.com/read/28760677/optical-coherence-tomography-angiography-a-comprehensive-review-of-current-methods-and-clinical-applications
#7
REVIEW
Amir H Kashani, Chieh-Li Chen, Jin K Gahm, Fang Zheng, Grace M Richter, Philip J Rosenfeld, Yonggang Shi, Ruikang K Wang
OCT has revolutionized the practice of ophthalmology over the past 10-20 years. Advances in OCT technology have allowed for the creation of novel OCT-based methods. OCT-Angiography (OCTA) is one such method that has rapidly gained clinical acceptance since it was approved by the FDA in late 2016. OCTA images are based on the variable backscattering of light from the vascular and neurosensory tissue in the retina. Since the intensity and phase of backscattered light from retinal tissue varies based on the intrinsic movement of the tissue (e...
July 28, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28721309/retinal-pigment-epithelial-cells-are-a-potential-reservoir-for-ebola-virus-in-the-human-eye
#8
Justine R Smith, Shawn Todd, Liam M Ashander, Theodosia Charitou, Yuefang Ma, Steven Yeh, Ian Crozier, Michael Z Michael, Binoy Appukuttan, Keryn A Williams, David J Lynn, Glenn A Marsh
PURPOSE: Success of Ebola virus (EBOV) as a human pathogen relates at the molecular level primarily to blockade the host cell type I interferon (IFN) antiviral response. Most individuals who survive Ebola virus disease (EVD) develop a chronic disease syndrome: approximately one-quarter of survivors suffer from uveitis, which has been associated with presence of EBOV within the eye. Clinical observations of post-Ebola uveitis indicate involvement of retinal pigment epithelial cells. METHODS: We inoculated ARPE-19 human retinal pigment epithelial cells with EBOV, and followed course of infection by immunocytochemistry and measurement of titer in culture supernatant...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28720143/mhc-class-ii-expression-and-potential-antigen-presenting-cells-in-the-retina-during-experimental-autoimmune-uveitis
#9
Deborah A Lipski, Rémi Dewispelaere, Vincent Foucart, Laure E Caspers, Matthieu Defrance, Catherine Bruyns, François Willermain
BACKGROUND: Controversy exists regarding which cell types are responsible for autoantigen presentation in the retina during experimental autoimmune uveitis (EAU) development. In this study, we aimed to identify and characterize the retinal resident and infiltrating cells susceptible to express major histocompatibility complex (MHC) class II during EAU. METHODS: EAU was induced in C57BL/6 mice by adoptive transfer of autoreactive lymphocytes from IRBP1-20-immunized animals...
July 18, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28665750/cat-scratch-disease-not-a-benign-condition
#10
Sandra Barros, Gabriel Costa De Andrade, Cecilia Cavalcanti, Heloisa Nascimento
PURPOSE: Describe a case series of ocular Cat-scratch-disease (CSD) with vision-threatening findings and poor outcomes, indicating severity of disease. METHODS: Retrospective case series from the Uveitis Department of São Paulo Federal University from 2011 to 2015. RESULTS: In this period, six eyes of four patients had confirmed diagnosis of CSD. Two were male and two female. Mean age was 24.8 years old [7-45]. Two had bilateral disease. Visual acuity at presentation ranged from no light perception to 20/25...
June 30, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28622198/ocular-sarcoidosis-new-diagnostic-modalities-and-treatment
#11
Sung J Yang, Sherveen Salek, James T Rosenbaum
PURPOSE OF REVIEW: Ocular involvement in sarcoidosis is present in up to 80% of patients and is frequently manifested before diagnosis of the underlying systemic disease. Considering the therapeutic consequences, early diagnosis of the underlying disease is advantageous in patients presenting with ocular inflammation. There are several ocular findings suggestive of underlying sarcoidosis, such as granulomatous keratic precipitates, iris nodules, cells in the vitreous humor known as snowballs and snowbanks, and retinal periphlebitis...
September 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28597994/corneal-sensitivity-and-tear-production-in-108-horses-with-ocular-disease
#12
Kelly E Knickelbein, Nicole M Scherrer, Mary Lassaline
PURPOSE: To compare corneal sensitivity and tear production in horses with keratitis to horses with other ocular disease. METHOD: Retrospective medical record review was used to identify equine patients presented during a 1-year period for an ocular complaint who had Schirmer Tear Test (STT) or Corneal Touch Threshold (CTT) measured. Variables studied included patient age and sex; affected eye; category of presenting ocular complaint (keratitis vs. other ocular complaint); STT; and CTT...
June 9, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28596917/assessment-of-vascular-change-using-swept-source-optical-coherence-tomography-angiography-a-new-theory-explains-central-visual-loss-in-behcet-s-disease
#13
Thanapong Somkijrungroj, Sritatath Vongkulsiri, Wijak Kongwattananon, Peranut Chotcomwongse, Sasivarin Luangpitakchumpol, Korrawan Jaisuekul
OBJECTIVE: To evaluate retinal vascular structural change in ocular Behcet's using optical coherence tomography angiography (OCTA) and fluorescein angiography (FA). METHODS: An analytic cross-sectional study of 37 eyes of 21 Behcet's uveitic patients was performed. Foveal retinal thickness (FRT), perifoveal hypoperfusion areas in superficial capillary plexus (SCP), and deep capillary plexus (DCP) were measured with swept-source optical coherence tomography and OCTA...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28585111/morphometric-features-on-enhanced-depth-imaging-optical-coherence-tomography-scans-in-idiopathic-posterior-uveitis-or-panuveitis
#14
Rupesh Agrawal, Rashi Arora, Pearse A Keane, Aniruddha Agarwal, Carlos Pavesio
PURPOSE: Enhanced depth imaging (EDI) optical coherence tomography (OCT) has emerged as a novel tool for qualitative and quantitative choroidal assessment in posterior uveitis. The objective of this study was to investigate the role of EDI-OCT to assess the choroidal and retinal changes in posterior uveitis. METHODS: In this retrospective study, EDI-OCT scans of patients with idiopathic posterior uveitis or panuveitis were reviewed. Morphological features from retina and choroid from the OCT scans were assessed and compared to the fellow normal eyes...
June 5, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28562149/in-vivo-laser-confocal-microscopy-using-the-hrt-rostock-cornea-module-diversity-and-diagnostic-implications-in-patients-with-uveitis
#15
Lyndell L Lim, Jing Xie, Chyn C Chua, Tiffany Wong, Lani T Hoang, Matthias D Becker, Eric B Suhler, James T Rosenbaum, Friederike Mackensen
PURPOSE: Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications. METHODS: Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers. RESULTS: 120 scans on 120 eyes from 110 subjects were included. The majority (N = 93) had non-infectious uveitis...
May 31, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28558009/association-between-aqueous-humor-and-vitreous-fluid-levels-of-th17-cell-related-cytokines-in-patients-with-proliferative-diabetic-retinopathy
#16
Masaru Takeuchi, Tomohito Sato, Yutaka Sakurai, Manzo Taguchi, Kozo Harimoto, Yoko Karasawa, Masataka Ito
Inflammation is known to be involved in the progression of diabetic retinopathy. We have recently reported that vitreous levels of IL-4, IL-17A, IL-22, IL-31, and TNFα are higher than the respective serum levels in proliferative diabetic retinopathy (PDR) patients, and that vitreous levels of these cytokines are higher in PDR than in other non-inflammatory vitreoretinal diseases or uveitis associated with sarcoidosis. In the present study, we investigated inflammatory cytokines including Th17 cell-related cytokines in aqueous humor samples obtained from eyes with PDR, and analyzed the association between the aqueous humor and vitreous fluid levels of individual cytokines...
2017: PloS One
https://www.readbyqxmd.com/read/28557602/systemic-steroid-sparing-effect-of-intravitreal-dexamethasone-implant-in-chronic-noninfectious-uveitic-macular-edema
#17
Claudia Fabiani, Antonio Vitale, Giacomo Emmi, Giuseppe Lopalco, Lorenzo Vannozzi, Daniela Bacherini, Silvana Guerriero, Rosa Anna Favale, Fiorella Fusco, Rossella Franceschini, Bruno Frediani, Florenzo Iannone, Mauro Galeazzi, Gian Marco Tosi, Luca Cantarini
PURPOSE: To evaluate the effectiveness and the systemic corticosteroid sparing effect of a single intravitreal dexamethasone (DEX) implant in patients with chronic noninfectious uveitic macular edema (UME). METHODS: Data from 22 eyes treated with DEX implant for UME related to systemic or ocular-confined noninfectious diseases were retrospectively analyzed. RESULTS: The mean systemic prednisone (or equivalent) dosage significantly decreased at 3- and 6-month follow-up evaluations compared to baseline (P = 0...
May 30, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28557287/epidemiology-and-clinical-features-of-inflammatory-retinal-vascular-occlusions-pooled-data-from-two-tertiary-referral-institutions
#18
Aniruddha Agarwal, Samendra Karkhur, Kanika Aggarwal, Alessandro Invernizzi, Ramandeep Singh, Mangat R Dogra, Vishali Gupta, Amod Gupta, Diana V Do, Quan D Nguyen
IMPORTANCE: In a subset of patients with retinal vasculitis, there is occlusion of blood flow through the retinal vessels. These eyes are at high risk of sight-threatening complications. BACKGROUND: To characterize epidemiology, clinical course, treatment and outcomes of occlusive retinal vasculitis (ORV). DESIGN: Retrospective study PARTICIPANTS: Seventy-seven uveitis patients with ORV at two large tertiary-care institutions (the USA and India)...
May 29, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28539679/the-association-of-pathergy-reaction-and-active-clinical-presentations-of-beh%C3%A3-et-s-disease
#19
Shirin Assar, Bahar Sadeghi, Fereydoun Davatchi, Seyyedeh Zahra Ghodsi, Abdolhadi Nadji, Farhad Shahram, Farimah Ashofte, Seyyedeh Roghieh Larimi, Masoud Sadeghi
OBJECTIVES: The pathergy skin test is a hypersensitivity reaction to a prick skin trauma caused by a pin or a needle, which is considered as a specific presentation in Behçet's disease (BD) and the precise mechanism of this test is not well elucidated. This study was designed to evaluate the association of pathergy reaction (PR) with the active clinical manifestations of BD patients, to assess the clinical importance of PR. MATERIALS AND METHODS: This was a cohort study on 1675 BD patients who fulfilled the entry criteria based on the International Criteria for Behçet's Disease (ICBD) from 1975 to 2011...
2017: Reumatologia
https://www.readbyqxmd.com/read/28524639/high-dose-intravenous-steroid-pulse-therapy-in-ocular-involvement-of-behcet-s-disease-a-pilot-double-blind-control-study
#20
Mastaneh Mohammadi, Farhad Shahram, Hormoz Shams, Massoomeh Akhlaghi, Farimah Ashofteh, Fereydoun Davatchi
AIM: To evaluate the efficacy of intravenous high-dose pulses of methylprednisolone (IVPM) for treatment of ocular involvement in Behcet's disease (BD). METHOD: In a double-blind control study, we randomized BD patients with posterior uveitis (PU) and/or retinal vasculitis (RV) into two groups. They received either IVPM (1000 mg methylprednisolone) or placebo for 3 consecutive days. Both groups received combination therapy with IV cyclophosphamide, azathioprine and prednisolone for 6 months...
May 19, 2017: International Journal of Rheumatic Diseases
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