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https://www.readbyqxmd.com/read/28717659/identification-and-characterization-of-variants-and-a-novel-4%C3%A2-bp-deletion-in-the-regulatory-region-of-six6-a-risk-factor-for-primary-open-angle-glaucoma
#1
Mohd Hussain Shah, Noemi Tabanera, Subbaiah Ramasamy Krishnadas, Manju R Pillai, Paola Bovolenta, Periasamy Sundaresan
BACKGROUND: Primary open-angle glaucoma (POAG) is a complex disease of multigenic inheritance and the most common subtype of glaucoma. SIX6 encodes a transcription factor involved in retina, optic nerve, and pituitary development. Previous studies showed a genetic association between the SIX6 locus and POAG, identifying risk alleles. Whether these alleles are present also in the south Indian population is unclear. METHODS: To address this question, the SIX6 gene and an already characterized and highly conserved SIX6 enhancer (Ch14:60974427-60974430) were sequenced in two south Indian cohorts, respectively, composed of 65/65 and 200/200 POAG cases/age-matched controls...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28717139/relationship-between-retinal-inner-nuclear-layer-thickness-and-severity-of-visual-field-loss-in-glaucoma
#2
Eun Kyoung Kim, Hae-Young Lopilly Park, Chan Kee Park
Glaucoma is a disease characterized by pathologic changes in inner retinal layers, which are comprised of retinal ganglion cells (RGCs). As retinal ganglion cells (RGCs) cross over other retinal neurons that are connected by synapses, it is meaningful to investigate the outer retinal changes in glaucoma. We evaluated the association between thicknesses of segmented retinal layers in macular region and severity of visual field loss in open-angle glaucoma (OAG). This study involved 103 glaucomatous eyes. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL) thicknesses were measured at the macular level using the Spectral-domain optical coherence tomography with segmentation software...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715584/reduced-retinal-vessel-density-in-obstructive-sleep-apnea-syndrome-patients-an-optical-coherence-tomography-angiography-study
#3
Jian Yu, Kuanlin Xiao, Jingjing Huang, Xinghuai Sun, Chunhui Jiang
Purpose: To examine the retinal vasculature in patients with obstructive sleep apnea-hypopnea syndrome (OSAS) and to determine the correlation between retinal vascularity and the severity of OSAS. Design: Prospective, cross-sectional study. Methods: Sixty-nine consecutive subjects who underwent polysomnography were enrolled. Patients were divided into three groups according to the severity of OSAS, which was defined using the apnea-hypopnea index (AHI) as normal-to-mild (AHI <15), moderate (≥15 to <30), or severe (≥30)...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28706282/retinal-degeneration-in-progressive-supranuclear-palsy-measured-by-optical-coherence-tomography-and-scanning-laser-polarimetry
#4
Birthe Stemplewitz, Robert Kromer, Eik Vettorazzi, Ute Hidding, Andreas Frings, Carsten Buhmann
This cross-sectional study compared the retinal morphology between patients with progressive supranuclear palsy (PSP) and healthy controls. (The retinal nerve fiber layer (RNFL) around the optic disc and the retina in the macular area of 22 PSP patients and 151 controls were investigated by spectral domain optical coherence tomography (SD-OCT). Additionally, the RNFL and the nerve fiber index (NFI) were measured by scanning laser polarimetry (SLP). Results of RNFL measurements with SD-OCT and SLP were compared to assess diagnostic discriminatory power...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28700902/a-novel-algorithm-to-detect-glaucoma-risk-using-texton-and-local-configuration-pattern-features-extracted-from-fundus-images
#5
U Rajendra Acharya, Shreya Bhat, Joel E W Koh, Sulatha V Bhandary, Hojjat Adeli
Glaucoma is an optic neuropathy defined by characteristic damage to the optic nerve and accompanying visual field deficits. Early diagnosis and treatment are critical to prevent irreversible vision loss and ultimate blindness. Current techniques for computer-aided analysis of the optic nerve and retinal nerve fiber layer (RNFL) are expensive and require keen interpretation by trained specialists. Hence, an automated system is highly desirable for a cost-effective and accurate screening for the diagnosis of glaucoma...
June 29, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28699929/arcuate-nerve-fiber-layer-changes-after-internal-limiting-membrane-peeling-in-idiopathic-epiretinal-membrane
#6
Andrea Scupola, Gabriela Grimaldi, Edoardo Abed, Maria G Sammarco, Andrea Giudiceandrea, Andrea Greco, Paola Sasso, Maria A Blasi
PURPOSE: To analyze the relationship between swelling of the arcuate nerve fiber layer (SANFL) and long-term decrease of retinal nerve fiber layer thickness after internal limiting membrane peeling for idiopathic epiretinal membrane, and to investigate if SANFL is related to a mechanical surgical damage. METHODS: Prospective, interventional consecutive case series of 46 eyes that underwent combined epiretinal membrane/internal limiting membrane peeling for idiopathic epiretinal membrane...
July 7, 2017: Retina
https://www.readbyqxmd.com/read/28687846/comparison-of-the-retinal-microvascular-density-between-open-angle-glaucoma-and-nonarteritic-anterior-ischemic-optic-neuropathy
#7
Chun-Hsiu Liu, Wei-Chi Wu, Ming-Hui Sun, Ling-Yuh Kao, Yung-Sung Lee, Henry Shen-Lih Chen
Purpose: To compare optical coherence tomography angiography (OCT-A) retinal vasculature measurements between nonarteritic anterior ischemic optic neuropathy (NAION) and open angle glaucoma (OAG) with altitudinal hemifield visual field defects. Methods: This retrospective cross-sectional study included 10 NAION eyes and 16 OAG eyes, both demonstrating hemifield visual field defects, and 27 normal eyes serving as controls. The peripapillary and macular OCT-A scans were acquired...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28683484/-retinal-nerve-fiber-layer-thickness-measurements-with-optical-coherence-tomography-in-glaucoma-patients-and-healthy-controls
#8
Christian Yahya Mardin
Thickness measurements of the retinal nerve fiber layer in glaucomas have become an important tool for diagnosis and follow-up of progression. High image resolution and advanced evaluation algorithms led to this achievement. In the following OCT anatomy, imaging technique, normative values, monitoring of progression and the influence of artefacts on OCT measurements are matter of discussion. Knowledge of capabilities and pitfalls of RNF imaging with OCT should help to integrate this technique into daily patient routine...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28683479/-diagnostic-precision-of-the-confocal-scanning-laser-ophthalmoscopy-in-the-large-optic-disc-with-physiological-excavation-a-long-term-study
#9
Eva Charlotte Koch, Niklas Plange, Matthias Fuest, Hannah Schimitzek, David Kuerten
We repeatedly examined 17 subjects with presumed bilateral physiological excavation labeled as pathological and/or borderline via HRT to verify the diagnosis of physiological cupping or to monitor the long-term progression into normal tension glaucoma. Patients and Methods 17 Subjects with presumed bilateral physiological cupping and large optic discs were included in this long-term follow-up study. All subjects underwent regular detailed ophthalmologic examinations, including intraocular pressure measurement via Goldmann applanation tonometry (GAT), retinal nerve fiber layer imaging via optical coherence tonometry (OCT) and visual field testing and optic disc imaging using the HRT...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28678834/normative-database-for-separate-inner-retinal-layers-thickness-using-spectral-domain-optical-coherence-tomography-in-caucasian-population
#10
María Nieves-Moreno, Jose M Martínez-de-la-Casa, Pilar Cifuentes-Canorea, Marina Sastre-Ibáñez, Enrique Santos-Bueso, Federico Sáenz-Francés, Laura Morales-Fernández, Julián García-Feijoó
PURPOSE: Develop the first normative database of the thickness of every inner retinal layer in the macular area in a healthy, Caucasian population between 18 to 87 years old, using Spectralis Optical Coherence Tomography (OCT). METHODS: On this transversal, observational study, 300 patients between 18 to 87 years old and without an ophthalmological condition were recruited. Macular OCT scans were performed on all patients (Spectralis OCT, Heidelberg Engineering)...
2017: PloS One
https://www.readbyqxmd.com/read/28676353/more-sensitive-correlation-of-afferent-pupillary-defect-with-ganglion-cell-complex
#11
Eulogio Besada, Barry J Frauens, Rim Makhlouf, Diana Shechtman, Julie Rodman, Marlon Demeritt, Patrick Hardigan
PURPOSE: This study investigated the correlation between the relative afferent pupillary defect (RAPD) and retinal nerve fiber layer thickness (RNFLT) in optic neuropathy. METHODS: RAPD assessment was performed using a log unit neutral density filter bar. Spectral domain optical coherence tomography RTVue-100 (Optovue) was used to examine the subjects. The optic nerve head pattern (ONH) was subdivided and identified for the purpose of the study into circumpapillary RNFLT (cpRNFLT) and peripheral circumpapillary RNFLT (pcpRNFLT)...
July 1, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28676313/ganglion-cell-complex-loss-precedes-retinal-nerve-fiber-layer-thinning-in-patients-with-pituitary-adenoma
#12
Yichao Zhang, Zhao Ye, Min Wang, Nidan Qiao
No abstract text is available yet for this article.
July 1, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28676014/citicoline-and-retinal-ganglion-cells-effects-on-morphology-and-function
#13
Vincenzo Parisi, Francesco Oddone, Lucia Ziccardi, Gloria Roberti, Gianluca Coppola, Gianluca Manni
Retinal ganglion cells (RGCs) are the nervous retinal elements that connect the visual receptors to the brain forming the nervous visual system. Functional and/or morphological involvement of RGCs occurs in several ocular and neurological disorders and therefore these cells are targeted in neuroprotective strategies. Cytidine 5-diphosphocholine or Citicoline is an endogenous compound that acts in the biosynthesis of phospholipids of cell membranes and increases neurotransmitters' levels in the Central Nervous System...
July 3, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28671919/evaluation-of-layer-by-layer-segmented-ganglion-cell-complex-thickness-for-detecting-early-glaucoma-according-to-different-macular-grids
#14
Hae Jin Kim, Ki Ho Park, Young Kook Kim, Jin Wook Jeoung
PURPOSE: To investigate the diagnostic performance of layer-by-layer segmented macular ganglion cell complex (GCC) thickness for detecting early glaucoma using spectral-domain optical coherence tomography (SD-OCT) with different macular grids. MATERIALS AND METHODS: Sixty-two early-stage open-angle glaucoma patients and 70 healthy subjects were enrolled in this study. The SD-OCT with automated segmentation was used to obtain macular scans with different grids of "1, 2, and 3 mm"; "1, 2...
June 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28669780/impact-of-normal-aging-and-progression-definitions-on-the-specificity-of-detecting-retinal-nerve-fiber-layer-thinning
#15
Zhichao Wu, Luke J Saunders, Linda M Zangwill, Fábio B Daga, Jonathan G Crowston, Felipe A Medeiros
PURPOSE: To evaluate the specificity of current definitions used to identify progressive change of the average peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained on optical coherence tomography (OCT) imaging. DESIGN: Prospective observational cohort study METHODS: Setting: University of California, San Diego. STUDY POPULATION: 75 eyes from 45 normal participants. OBSERVATION PROCEDURE: Patients were seen at an average of 5...
June 29, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28669275/early-retinal-atrophy-predicts-long-term-visual-impairment-after-acute-optic-neuritis
#16
Bernardo Sanchez-Dalmau, Elena H Martinez-Lapiscina, Ruben Torres-Torres, Santiago Ortiz-Perez, Irati Zubizarreta, Irene V Pulido-Valdeolivas, Salut Alba-Arbalat, Ana Guerrero-Zamora, David Calbet, Pablo Villoslada
BACKGROUND: Visual recovery after optic neuritis (ON) used to be defined as good, although patients frequently complain of poor vision. METHODS: We carried out a prospective study on 38 consecutive patients with acute ON followed monthly for 6 months and evaluated high- and low-contrast visual acuity (HCVA and LCVA, respectively), quality of vision (National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25)), visual fields, and retinal thickness by spectral domain optical coherence tomography (OCT)...
June 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28668999/heterozygous-deletion-of-the-opa1-gene-in-patients-with-dominant-optic-atrophy
#17
Takaaki Hayashi, Hiroyuki Sasano, Satoshi Katagiri, Kazushige Tsunoda, Shuhei Kameya, Mitsuru Nakazawa, Takeshi Iwata, Hiroshi Tsuneoka
PURPOSE: Several OPA1 variants cause dominant optic atrophy (DOA), the most common hereditary optic atrophy. Here, we describe a newly discovered OPA1 deletion in 3 patients with DOA. METHODS: A female proband, her brother, and her mother underwent complete ophthalmologic examinations that included optical coherence tomography and visual field assessments using a Humphrey Field Analyzer with both standard automated perimetry (SAP) and short-wavelength automated perimetry (SWAP)...
July 1, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28668421/quantitative-assessment-of-optic-nerve-in-patients-with-leber-s-hereditary-optic-neuropathy-using-reduced-field-of-view-diffusion-tensor-imaging
#18
Ling Wang, Ke Fan, Yanqiu Zhang, Yanzi Chen, Qin Tian, Dapeng Shi
PURPOSE: To quantitatively analyze the optic nerve alterations in chronic Leber's hereditary optic neuropathy (LHON) using reduced field-of-view diffusion tensor imaging (rFOV-DTI) and evaluate the correlation of diffusion parameters with visual functional and peripapillary retinal nerve fiber layer (RNFL) thickness. METHODS: Twenty-five patients (50 affected optic nerves) with chronic LHON and 28 healthy controls (56 normal optic nerves) were enrolled. The rFOV-DTI was performed in the bilateral optic nerves for all the subjects...
August 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28660081/analysis-of-peripapillary-retinal-vessel-diameter-in-unilateral-normal-tension-glaucoma
#19
Yong Un Shin, Sang Eon Lee, Heeyoon Cho, Min Ho Kang, Mincheol Seong
PURPOSE: This study sought to analyze peripapillary retinal vessel diameter and evaluate its correlation with retinal nerve fiber layer (RNFL) thickness in patients with unilateral normal-tension glaucoma (NTG). METHODS: This retrospective study included 37 patients with unilateral NTG and 40 healthy controls. The unilateral NTG patients were selected based on RNFL photography and unilateral visual field (VF) defects from the Humphrey central 30-2 threshold test...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28660077/relationship-between-retinal-nerve-fiber-layer-thickness-and-hemoglobin-present-in-the-optic-nerve-head-in-glaucoma
#20
Marta Gonzalez-Hernandez, Jose Sigut Saavedra, Manuel Gonzalez de la Rosa
PURPOSE: To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. METHODS: 96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from conventional color photographs (Horus Scope DEC 200 fundus camera). RESULTS: The correlation between Laguna ONhE glaucoma discriminant function (GDF) and SPECTRALIS BMO-MRW was R = 0...
2017: Journal of Ophthalmology
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