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https://www.readbyqxmd.com/read/29614220/liquid-state-nmr-analysis-of-nanocelluloses
#1
Alistair William Thomas King, Valtteri Mäkelä, Stephanie A Kedzior, Tiina Laaksonen, Gabriel J Partl, Sami Heikkinen, Harri Koskela, Harri August Heikkinen, Ashley John Holding, Emily D Cranston, Ilkka Antero Kilpeläinen
Recent developments in ionic liquid electrolytes for cellulose or biomass dissolution has also allowed for high-resolution1 H and13 C NMR on very high molecular weight cellulose. This permits the development of advanced liquid-state quantitative NMR methods for characterization of unsubstituted and low degree of substitution celluloses, e.g. surface-modified nanocelluloses, which are insoluble in all molecular solvents. As such, we present the use of the tetrabutylphosphonium acetate ([P4444 ][OAc]):DMSO-d6 electrolyte in the 1D and 2D NMR characterization of poly(methylmethacrylate) (PMMA)-grafted cellulose nanocrystals (CNCs)...
April 3, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29542919/directed-ortho-metalation-and-anionic-ortho-fries-rearrangement-of-polycyclic-aromatic-o-carbamates-regioselective-synthesis-of-substituted-chrysenes
#2
Sindhu Kancherla, Marianne Lorentzen, Victor Snieckus, Kåre B Jørgensen
A general method for the regioselective synthesis of a series of ortho-substituted chrysenyl N, N-diethyl- O-carbamates by the directed ortho-metalation (D oM) strategy is reported. The starting O-carbamates were prepared from the corresponding chrysenols, available by oxidative photochemical cyclization or directed remote metalation tactics. Chrysen-1-yl and chrysene-3-yl ring site selectivity of directed ortho-metalation (D oM) and anionic ortho-Fries rearrangement (A oF) protocols, with s-BuLi/TMEDA, followed by electrophilic quench using a selection of electrophiles, were observed, leading to new chrysenyl derivatives...
April 6, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29489358/convergent-strategy-to-dizocilpine-mk-801-and-derivatives
#3
K Harsha Vardhan Reddy, Expédite Yen-Pon, Sylvia Cohen-Kaminsky, Samir Messaoudi, Mouad Alami
A convergent total synthesis of MK-801 has been achieved. Key synthetic transformations include a multicomponent Barbier-type reaction to construct the α-branched amine, a selective Heck α-coupling tactic to generate the exocyclic alkene skeleton, and a late-stage intramolecular hydroamination reaction between the exocyclic alkene and the secondary protected amine. The efficacy of this method was demonstrated by the synthesis of two news analogues substituted on the aromatic rings.
April 6, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29328877/designing-difference-in-difference-studies-best-practices-for-public-health-policy-research
#4
Coady Wing, Kosali Simon, Ricardo A Bello-Gomez
The difference in difference (DID) design is a quasi-experimental research design that researchers often use to study causal relationships in public health settings where randomized controlled trials (RCTs) are infeasible or unethical. However, causal inference poses many challenges in DID designs. In this article, we review key features of DID designs with an emphasis on public health policy research. Contemporary researchers should take an active approach to the design of DID studies, seeking to construct comparison groups, sensitivity analyses, and robustness checks that help validate the method's assumptions...
April 1, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29243038/what-performance-analysts-need-to-know-about-research-trends-in-association-football-2012-2016-a-systematic-review
#5
REVIEW
Hugo Sarmento, Filipe Manuel Clemente, Duarte Araújo, Keith Davids, Allistair McRobert, António Figueiredo
BACKGROUND: Evolving patterns of match analysis research need to be systematically reviewed regularly since this area of work is burgeoning rapidly and studies can offer new insights to performance analysts if theoretically and coherently organized. OBJECTIVE: The purpose of this paper was to conduct a systematic review of published articles on match analysis in adult male football, identify and organize common research topics, and synthesize the emerging patterns of work between 2012 and 2016, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines...
April 2018: Sports Medicine
https://www.readbyqxmd.com/read/29191047/stealth-lipid-polymer-hybrid-nanoparticles-loaded-with-rutin-for-effective-brain-delivery-comparative-study-with-the-gold-standard-tween-80-optimization-characterization-and-biodistribution
#6
Rania A H Ishak, Nada M Mostafa, Amany O Kamel
The blood-brain barrier is considered the leading physiological obstacle hindering the transport of neurotherapeutics to brain cells. The application of nanotechnology coupled with surfactant coating is one of the efficacious tactics overcoming this barrier. The aim of this study was to develop lipid polymer hybrid nanoparticles (LPHNPs), composed of a polymeric core and a phospholipid shell entangled, for the first time, with PEG-based surfactants (SAA) viz. TPGS or Solutol HS 15 in comparison with the gold standard Tween 80, aiming to enhance brain delivery and escape opsonization...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28933552/metal-and-solvent-free-approach-to-diversely-substituted-picolinates-via-domino-reaction-of-cyclic-sulfamidate-imines-with-%C3%AE-%C3%AE-unsaturated-%C3%AE-ketocarbonyls
#7
Soumen Biswas, Debashis Majee, Soumitra Guin, Sampak Samanta
An efficient, solvent-free, and eco-friendly domino reaction of 5/6-membered cyclic sulfamidate imines with a variety of β,γ-unsaturated α-ketocarbonyls in neat conditions under MW irradiation promoted by DABCO as a solid organobase has been developed for the rapid construction of a novel class of densely functionalized picolinates. This interesting metal-solvent-free tactic allows a wide range of useful functionalities on the aryl rings and delivers good to excellent yields of the aforesaid aza-heterocycles within short time spans (20-40 min)...
October 2, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28921610/validation-and-adaptation-of-the-danger-assessment-5-da-5-a-brief-intimate-partner-violence-risk-assessment
#8
Jill Theresa Messing, Jacquelyn C Campbell, Carolyn Snider
AIMS: To assess the predictive validity of the DA-5 with the addition of a strangulation item in evaluating the risk of an intimate partner violence (IPV) victim being nearly killed by an intimate partner. BACKGROUND: The DA-5 was developed as a short form of the Danger Assessment for use in healthcare settings, including emergency and urgent care settings. Analyzing data from a sample of IPV survivors who had called the police for domestic violence, the DA-5 was tested with and without an item on strangulation, a potentially fatal and medically damaging IPV tactic used commonly by dangerous abusers...
September 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28749251/identification-of-spirocyclic-or-phosphate-substituted-quinolizine-derivatives-as-novel-hiv-1-integrase-inhibitors-a-patent-evaluation-of-wo2016094197a1-wo2016094198a1-and-wo2016154527a1
#9
REVIEW
Xiqiang Cheng, Ping Gao, Lin Sun, Ye Tian, Peng Zhan, Xinyong Liu
Highly active antiretroviral therapy (HAART) has been widely adopted to control the HIV-1 infection successfully. HIV-1 integrase (IN) inhibitors are primary drugs in HAART regimens targeting integration step in the HIV-1 life cycle. However, due to the emergence of viral resistance and cross-resistance amongst drugs, there is a pressing need for new and potent IN inhibitors. This review covers the three patents describing spirocyclic and phosphate substituted quinolizine derivatives as novel HIV-1 IN inhibitors for the discovery of new anti-HIV-1 drug candidates...
November 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28722252/efficient-access-to-all-carbon-quaternary-and-tertiary-%C3%AE-functionalized-homoallyl-type-aldehydes-from-ketones
#10
Vittorio Pace, Laura Castoldi, Eugenia Mazzeo, Marta Rui, Thierry Langer, Wolfgang Holzer
β,γ-Unsaturated aldehydes with all-carbon quaternary or tertiary α-centers were rapidly assembled from ketones through a unique synthetic operation consisting of 1) C1 homologation, 2) Lewis acid mediated epoxide-aldehyde isomerization, and 3) electrophilic trapping. The synthetic equivalence of a vinyl oxirane and a β,γ-unsaturated aldehyde is the key concept of this previously undisclosed tactic. Mechanistic studies and labeling experiments suggest that an aldehyde enolate is a crucial intermediate...
October 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28620396/identification-of-a-potential-isr-determinant-from-pseudomonas-aeruginosa-pm12-against-fusarium-wilt-in-tomato
#11
Sabin Fatima, Tehmina Anjum
Biocontrol of plant diseases through induction of systemic resistance is an environmental friendly substitute to chemicals in crop protection measures. Different biotic and abiotic elicitors can trigger the plant for induced resistance. Present study was designed to explore the potential of Pseudomonas aeruginosa PM12 in inducing systemic resistance in tomato against Fusarium wilt. Initially the bioactive compound, responsible for ISR, was separated and identified from extracellular filtrate of P. aeruginosa PM12...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28613319/thermal-ring-opening-polymerization-of-an-unsymmetrical-silicon-bridged-1-ferrocenophane-in-coordination-nanochannels
#12
Yuichiro Kobayashi, Kayako Honjo, Susumu Kitagawa, Jessica Gwyther, Ian Manners, Takashi Uemura
Thermal ring-opening polymerization of the unsymmetrically substituted [1]ferrocenophane was performed in one-dimensional nanochannels of porous coordination polymers (PCPs). In contrast to conventional thermal polymerization in bulk, formation of cyclic polymer was inhibited in the channels. In addition, the tacticity of the resulting polymer was dependent on the pore size of PCPs.
June 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28546955/biofabrication-and-biomaterials-for-urinary-tract-reconstruction
#13
REVIEW
Moustafa M Elsawy, Achala de Mel
Reconstructive urologists are constantly facing diverse and complex pathologies that require structural and functional restoration of urinary organs. There is always a demand for a biocompatible material to repair or substitute the urinary tract instead of using patient's autologous tissues with its associated morbidity. Biomimetic approaches are tissue-engineering tactics aiming to tailor the material physical and biological properties to behave physiologically similar to the urinary system. This review highlights the different strategies to mimic urinary tissues including modifications in structure, surface chemistry, and cellular response of a range of biological and synthetic materials...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28019078/target-site-mutations-conferring-resistance-to-glyphosate-in-feathertop-rhodes-grass-chloris-virgata-populations-in-australia
#14
The D Ngo, Mahima Krishnan, Peter Boutsalis, Gurjeet Gill, Christopher Preston
BACKGROUND: Chloris virgata is a warm-season, C4 , annual grass weed affecting field crops in northern Australia that has become an emerging weed in southern Australia. Four populations with suspected resistance to glyphosate were collected in South Australia, Queensland and New South Wales, Australia, and compared with one susceptible (S) population to confirm glyphosate resistance and elucidate possible mechanisms of resistance. RESULTS: Based on the rate of glyphosate required to kill 50% of treated plants (LD50 ), glyphosate resistance (GR) was confirmed in four populations of C...
May 2018: Pest Management Science
https://www.readbyqxmd.com/read/27755986/tactics-for-preclinical-validation-of-receptor-binding-radiotracers
#15
REVIEW
Susan Z Lever, Kuo-Hsien Fan, John R Lever
INTRODUCTION: Aspects of radiopharmaceutical development are illustrated through preclinical studies of [125 I]-(E)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-4-(iodoallyl)piperazine ([125 I]-E-IA-BF-PE-PIPZE), a radioligand for sigma-1 (σ1 ) receptors, coupled with examples from the recent literature. Findings are compared to those previously observed for [125 I]-(E)-1-(2-(2,3-dimethoxy-5-yl)ethyl)-4-(iodoallyl)piperazine ([125 I]-E-IA-DM-PE-PIPZE). METHODS: Syntheses of E-IA-BF-PE-PIPZE and [125 I]-E-IA-BF-PE-PIPZE were accomplished by standard methods...
January 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27546719/beyond-chemoselectivity-catalytic-site-selective-aldolization-of-diketones-and-exploitation-for-enantioselective-alzheimer-s-drug-candidate-synthesis
#16
Thomas C Nugent, Foad Tehrani Najafian, Hussein Ali El Damrany Hussein, Ishtiaq Hussain
Site selectivity, differentiating instances of the same functional group type on one substrate, represents a forward-looking theme within chemistry: reduced dependence on protection/deprotection protocols for increased overall yield and step-efficiency. Despite these potential benefits and the expanded tactical advantages afforded to synthetic design, site selectivity remains elusive and especially so for ketone-based substrates. Herein, site-selective intermolecular mono-aldolization has been demonstrated for an array of prochiral 4-keto-substituted cyclohexanones with concomitant regio-, diastereo-, and enantiocontrol...
September 26, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27430659/-trip-sitting-in-the-black-hole-a-netnographic-study-of-dissociation-and-indigenous-harm-reduction
#17
Evelyn Hearne, Marie Claire Van Hout
An array of dissociative novel psychoactive substances, including "methoxetamine," "3-MeO-PCP," and "methoxphenidine," have emerged as substitutes for the illicit substance "ketamine." A netographic research methodology aimed to describe online, dissociative novel psychoactive substance users' perceptions of risk, informed knowledge around use, and indigenous harm-reduction practices as advocated within online drug fora, so as to provide credible information which can be used to inform public online health education and drug prevention...
September 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27384693/practitioners-perceptions-of-the-soccer-extra-time-period-implications-for-future-research
#18
Liam D Harper, Melissa Fothergill, Daniel J West, Emma Stevenson, Mark Russell
Qualitative research investigating soccer practitioners' perceptions can allow researchers to create practical research investigations. The extra-time period of soccer is understudied compared to other areas of soccer research. Using an open-ended online survey containing eleven main and nine sub questions, we gathered the perceptions of extra-time from 46 soccer practitioners, all working for different professional soccer clubs. Questions related to current practices, views on extra-time regulations, and ideas for future research...
2016: PloS One
https://www.readbyqxmd.com/read/27232659/rifamycin-biosynthetic-congeners-isolation-and-total-synthesis-of-rifsaliniketal-and-total-synthesis-of-salinisporamycin-and-saliniketals-a-and-b
#19
Yu Feng, Jun Liu, Yazmin P Carrasco, John B MacMillan, Jef K De Brabander
We describe the isolation, structure elucidation, and total synthesis of the novel marine natural product rifsaliniketal and the total synthesis of the structurally related variants salinisporamycin and saliniketals A and B. Rifsaliniketal was previously proposed, but not observed, as a diverted metabolite from a biosynthetic precursor to rifamycin S. Decarboxylation of rifamycin provides salinisporamycin, which upon truncation with loss of the naphthoquinone ring leads to saliniketals. Our synthetic strategy hinged upon a Pt(II)-catalyzed cycloisomerization of an alkynediol to set the dioxabicyclo[3...
June 8, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27228214/quantitative-assessment-of-the-impact-of-fluorine-substitution-on-p-glycoprotein-p-gp-mediated-efflux-permeability-lipophilicity-and-metabolic-stability
#20
Martin Pettersson, Xinjun Hou, Max Kuhn, Travis T Wager, Gregory W Kauffman, Patrick R Verhoest
Strategic replacement of one or more hydrogen atoms with fluorine atom(s) is a common tactic to improve potency at a given target and/or to modulate parameters such as metabolic stability and pKa. Molecular weight (MW) is a key parameter in design, and incorporation of fluorine is associated with a disproportionate increase in MW considering the van der Waals radius of fluorine versus hydrogen. Herein we examine a large compound data set to understand the effect of introducing fluorine on the risk of encountering P-glycoprotein mediated efflux (as measured by MDR efflux ratio), passive permeability, lipophilicity, and metabolic stability...
June 9, 2016: Journal of Medicinal Chemistry
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