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https://www.readbyqxmd.com/read/29352540/insight-in-schizophrenia-spectrum-disorders-relationship-with-behavior-mood-and-perceived-quality-of-life-underlying-causes-and-emerging-treatments
#1
Paul H Lysaker, Michelle L Pattison, Bethany L Leonhardt, Scott Phelps, Jenifer L Vohs
Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this review, we examine the recent research on the relationship of insight with behavior, mood and perceived quality of life, on its complex roots, and on the effects of existing and emerging treatments. This research indicates that poor insight predicts poorer treatment adherence and therapeutic alliance, higher symptom severity and more impaired community function, while good insight predicts a higher frequency of depression and demoralization, especially when coupled with stigma and social disadvantage...
February 2018: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/29352400/project-date-smart-a-dating-violence-dv-and-sexual-risk-prevention-program-for-adolescent-girls-with-prior-dv-exposure
#2
Christie J Rizzo, Meredith Joppa, David Barker, Charlene Collibee, Caron Zlotnick, Larry K Brown
This study assessed the initial feasibility, acceptability, and efficacy of an intervention aimed at reducing dating violence and sexual risk behavior in a sample of adolescent girls (ages 14-17) with prior exposure to physical dating violence (DV). One hundred and nine girls were randomly assigned to Date SMART (Skills to Manage Aggression in Relationships for Teens) or a Knowledge-only (KO) comparison group. Both intervention arms consisted of six, weekly 2-h sessions and one "booster" session 6 weeks later...
January 20, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29352362/a-preliminary-examination-of-the-link-between-maternal-experiential-avoidance-and-parental-accommodation-in-anxious-and-non-anxious-children
#3
Leah Feinberg, Caroline Kerns, Donna B Pincus, Jonathan S Comer
Studies point to parental experiential avoidance (EA) as a potential correlate of maladaptive parenting behaviors associated with child anxiety. However, research has not examined the relationship between EA and parental accommodation of child anxiety, nor the extent to which parental negative beliefs about child anxiety help explain such a relationship. In a sample of mothers (N = 45) of anxious and non-anxious children, the present study investigated the potential link between maternal EA and accommodation of child anxiety and whether this link may be indirectly accounted for via maternal negative beliefs about child anxiety...
January 19, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29352314/proactive-vs-reactive-car-driving-eeg-evidence-for-different-driving-strategies-of-older-drivers
#4
Melanie Karthaus, Edmund Wascher, Stephan Getzmann
Aging is associated with a large heterogeneity in the extent of age-related changes in sensory, motor, and cognitive functions. All these functions can influence the performance in complex tasks like car driving. The present study aims to identify potential differences in underlying cognitive processes that may explain inter-individual variability in driving performance. Younger and older participants performed a one-hour monotonous driving task in a driving simulator under varying crosswind conditions, while behavioral and electrophysiological data were recorded...
2018: PloS One
https://www.readbyqxmd.com/read/29352267/differential-susceptibility-of-striatal-hippocampal-and-cortical-neurons-to-caspase-6
#5
Anastasia Noël, Libin Zhou, Bénédicte Foveau, P Jesper Sjöström, Andréa C LeBlanc
Active cysteinyl protease Caspase-6 is associated with early Alzheimer and Huntington diseases. Higher entorhinal cortex and hippocampal Caspase-6 levels correlate with lower cognitive performance in aged humans. Caspase-6 induces axonal degeneration in human primary neuron cultures and causes inflammation and neurodegeneration in mouse hippocampus, and age-dependent memory impairment. To assess whether Caspase-6 causes damage to another neuronal system, a transgenic knock-in mouse overexpressing a self-activated form of Caspase-6 five-fold in the striatum, the area affected in Huntington disease, and 2...
January 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29352154/resting-state-brain-networks-in-the-prairie-vole
#6
Juan J Ortiz, Wendy Portillo, Raul G Paredes, Larry J Young, Sarael Alcauter
Resting state functional magnetic resonance imaging (rsfMRI) has shown the hierarchical organization of the human brain into large-scale complex networks, referred as resting state networks. This technique has turned into a promising translational research tool after the finding of similar resting state networks in non-human primates, rodents and other animal models of great value for neuroscience. Here, we demonstrate and characterize the presence of resting states networks in Microtus ochrogaster, the prairie vole, an extraordinary animal model to study complex human-like social behavior, with potential implications for the research of normal social development, addiction and neuropsychiatric disorders...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352076/intestinal-dysbiosis-and-permeability-the-yin-and-yang-in-alcohol-dependence-and-alcoholic-liver-disease
#7
REVIEW
Peter Stärkel, Sophie Leclercq, Philippe de Timary, Bernd Schnabl
Alcohol dependence and alcoholic liver disease represent a major public health problem with substantial morbidity and mortality. By yet incompletely understood mechanisms, chronic alcohol abuse is associated with increased intestinal permeability and alterations of the gut microbiota composition, allowing bacterial components, bacteria, and metabolites to reach the portal and the systemic circulation. These gut-derived bacterial products are recognized by immune cells circulating in the blood or residing in remote organs such as the liver leading to the release of pro-inflammatory cytokines which are considered important mediators of the liver-gut-brain communication...
January 31, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29351965/cost-effectiveness-of-cognitive-behavioral-therapy-for-depressed-youth-declining-antidepressants
#8
John F Dickerson, Frances L Lynch, Michael C Leo, Lynn L DeBar, John Pearson, Gregory N Clarke
BACKGROUND AND OBJECTIVES: Adolescents with depression identified in primary care settings often have limited treatment options beyond antidepressant (AD) therapy. We assessed the cost-effectiveness of a brief cognitive behavioral therapy (CBT) program among depressed adolescents who declined or quickly stopped using ADs. METHODS: A total of 212 youth with depression were randomly assigned to treatment as usual (TAU) or TAU plus brief individual CBT. Clinical outcomes included depression-free days (DFDs) and estimated quality-adjusted life-years (QALYs)...
January 19, 2018: Pediatrics
https://www.readbyqxmd.com/read/29351711/-beck-anxiety-inventory-german-version-a-reliable-valid-patientfriendly-instrument-for-measuring-clinical-anxiety
#9
Edgar Geissner, Anne Huetteroth
The Beck Anxiety Inventory (BAI) is available in German. Apart from data in its manual, there are no further reports on the psychometric properties of this questionnaire and on its suitability for clinical use in Germany. This study therefore offers an independent investigation into the psychometrics as well as the clinical characteristics of the BAI. Three samples with n=145, n=90, and n=174 comprised inpatients diagnosed with anxiety disorders and treated in a large psychosomatic hospital. In addition to the BAI, the clinician rating Hamilton Anxiety Scale (HamA), the State-Trait-Anxiety Inventory (STAI) as well as the two anxiety subscales of the Symptom Checklist 90 (SCL 90) were used to establish convergent validity...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29351056/remediation-of-radiation-induced-cognitive-dysfunction-through-oral-administration-of-the-neuroprotective-compound-nsi-189
#10
Barrett Allen, Munjal M Acharya, Celine Lu, Erich Giedzinski, Nicole Chmielewski, David Quach, Mike Hefferan, Karl K Johe, Charles L Limoli
Clinical management of primary and secondary central nervous system (CNS) malignancies frequently includes radiotherapy to forestall tumor growth and recurrence after surgical resection. While cranial radiotherapy remains beneficial, adult and pediatric brain tumor survivors suffer from a wide range of debilitating and progressive cognitive deficits. Although this has been recognized as a significant problem for decades, there remains no clinical recourse for the unintended neurocognitive sequelae associated with these types of cancer treatments...
January 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29351005/an-integrated-operational-definition-and-conceptual-model-of-asthma-self-management-in-teens
#11
Jennifer Mammen, Hyekyun Rhee, Sally A Norton, Arlene M Butz, Jill S Halterman, Kimberly Arcoleo
OBJECTIVES: A previous definition of adolescent asthma self-management was derived from interviews with clinicians/researchers and published literature; however, it did not incorporate perspectives of teens or parents. Therefore, we conducted in-depth interviews with teens and parents and synthesized present findings with the prior analysis to develop a more encompassing definition and model. METHODS: Focal concepts were qualitatively extracted from 14-day self-management voice-diaries (n = 14) and 1-hour interviews (n = 42) with teens and parents (28 individuals) along with concepts found in the previous clinical/research oriented analysis...
January 19, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29351000/age-effects-on-cerebral-oxygenation-and-behavior-in-children-with-sleep-disordered-breathing
#12
Knarik Tamanyan, Lisa M Walter, Aidan Weichard, Margot J Davey, Gillian M Nixon, Sarah N Biggs, Rosemary Sc Horne
RATIONALE: Childhood sleep disordered breathing ranges in severity from primary snoring to obstructive sleep apnea and is associated with behavioral and neurocognitive deficits. It remains unknown why children with primary snoring, who do not experience peripheral oxygen desaturation or sleep fragmentation, experience similar daytime deficits as those with obstructive sleep apnea or why effects are age dependent. OBJECTIVE: To examine cerebral tissue oxygenation and oxygen extraction as an explanation for daytime deficits in children with primary snoring...
January 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29350708/sleep-wake-disturbance-a-systematic-review-of-evidence-based-interventions-for-management-in-patients-with-cancer
#13
Ellyn Matthews, Patricia Carter, Margaretta Page, Grace Dean, Ann Berger
BACKGROUND: New or worsening sleep-wake disturbance (SWD) can occur throughout the cancer trajectory.
. OBJECTIVES: The purpose of this article is to critically review available empirical evidence supporting the efficacy of interventions for SWD, highlighting new evidence since the 2006 and 2009 Putting Evidence Into Practice (PEP) SWD publications.
. METHODS: A systematic review of studies published from 2009-2017 was conducted to identify effective interventions for cancer-related SWD...
February 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29350556/rehabilitation-of-a-young-athlete-with-extension-based-low-back-pain-addressing-motor-control-impairments-and-central-sensitization
#14
John J Winslow, Mark Jackson, Andrew Getzin, Michael Costello
OBJECTIVE:   To describe the conservative management of a young athlete with extension-based (EB) low back pain (LBP). BACKGROUND:   We present the case of a 15-year-old female high school gymnast with a 4-year history of EB LBP. Magnetic resonance imaging revealed a healed spondylolysis and significant lumbar multifidi muscle (LMM) atrophy with fatty infiltrate. She had several courses of outpatient orthopaedic rehabilitation that focused on core muscle strengthening (improving activation and strength of the LMM and transversus abdominus muscle in a neutral pelvic position) without long-lasting improvement...
January 19, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29350085/divergent-classification-methods-of-post-concussion-syndrome-after-mild-traumatic-brain-injury-prevalence-rates-risk-factors-and-functional-outcome
#15
Daphne Cloë Voormolen, Maryse C Cnossen, Suzanne Polinder, Nicole von Steinbuechel, Pieter E Vos, Juanita Antje Haagsma
Mild Traumatic Brian Injury (mTBI) is a common diagnosis and approximately one third of mTBI patients experience a variety of cognitive, emotional, psychosocial and behavioral post-concussion symptoms. When a cluster of these symptoms persists for more than three months they are often classified as post-concussion syndrome (PCS). The objective of this study was to determine prevalence rates, risk factors and functional outcome associated with PCS six months after mTBI applying divergent classification methods...
January 19, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29349594/pacifists-and-revenge-seekers-in-response-to-unambiguous-peer-provocation
#16
Kristina L McDonald, Steven R Asher
In order to better understand why some children retaliate when they feel provoked and others do not, the present study identified "pacifistically-oriented" children who made negative interpretations in response to unambiguous provocations, yet did not endorse revenge goals, and compared them to "revenge-seeking" children who also made negative interpretations but did endorse revenge goals. Groups were identified based on seventh graders' (N = 367; 54.77% male; 22.89% racial/ethnic minority) responses to hypothetical situations in which a peer excluded and insulted them...
January 19, 2018: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29349291/spontaneous-infraslow-fluctuations-modulate-hippocampal-epsp-ps-coupling
#17
Michael B Dash, Stephen Ajayi, Lynde Folsom, Paul E Gold, Donna L Korol
Extensive trial-to-trial variability is a hallmark of most behavioral, cognitive, and physiological processes. Spontaneous brain activity (SBA), a ubiquitous phenomenon that coordinates levels and patterns of neuronal activity throughout the brain, may contribute to this variability by dynamically altering neuronal excitability. In freely-behaving male rats, we observed extensive variability of the hippocampal evoked response across 28-min recording periods despite maintaining constant stimulation parameters of the medial perforant path...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29348190/pronounced-hyperactivity-cognitive-dysfunctions-and-bdnf-dysregulation-in-dopamine-transporter-knockout-rats
#18
Damiana Leo, Ilya Sukhanov, Francesca Zoratto, Placido Illiano, Lucia Caffino, Fabrizio Sanna, Giulia Messa, Marco Emanuele, Alessandro Esposito, Maria Dorofeikova, Evgeny A Budygin, Liudmila Mus, Evgenia E Efimova, Marco Niello, Stefano Espinoza, Tatyana D Sotnikova, Marius C Hoener, Gianni Laviola, Fabio Fumagalli, Walter Adriani, Raul R Gainetdinov
Dopamine (DA) controls many vital physiological functions and is critically involved in several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder (ADHD). The major function of the plasma membrane dopamine transporter (DAT) is the rapid uptake of released DA into presynaptic nerve terminals leading to control of both the extracellular levels of DA and the intracellular stores of DA. Here, we present a newly developed strain of rats (DAT-knockout, DAT-KO rats) in which the gene encoding the DAT has been disrupted by using zinc finger nuclease technology (ZFN)...
January 18, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29347904/social-skills-training-and-play-group-intervention-for-children-with-oppositional-defiant-disorders-conduct-disorder-mediating-mechanisms-in-a-head-to-head-comparison
#19
Josepha Katzmann, Anja Goertz-Dorten, Christopher Hautmann, Manfred Doepfner
OBJECTIVE: Social-cognitive information processing, social skills, and social interactions are problem-maintaining variables for aggressive behavior in children. We hypothesized that these factors may be possible mediators of the mechanism of change in the child-centered treatment of conduct disorders (CDs). The aim of the present study (Clinical trials.gov Identifier: NCT01406067) was to examine putative mechanisms of change for the decrease in oppositional-defiant behavior resulting from child-centered treatment of patients with oppositional-defiant disorder (ODD) or CD...
January 19, 2018: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/29347888/patient-baseline-interpersonal-problems-as-moderators-of-outcome-in-two-psychotherapies-for-bulimia-nervosa
#20
Juan Martin Gomez Penedo, Michael J Constantino, Alice E Coyne, Samantha L Bernecker, Lotte Smith-Hansen
OBJECTIVE: We tested an aptitude by treatment interaction; namely, whether patients' baseline interpersonal problems moderated the comparative efficacy of cognitive-behavioral therapy (CBT) vs. interpersonal psychotherapy (IPT) for bulimia nervosa (BN). METHOD: Data derived from a randomized-controlled trial. Patients reported on their interpersonal problems at baseline; purge frequency at baseline, midtreatment, and posttreatment; and global eating disorder severity at baseline and posttreatment...
January 19, 2018: Psychotherapy Research: Journal of the Society for Psychotherapy Research
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