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https://www.readbyqxmd.com/read/28239823/inhibitory-effect-and-mechanism-of-metformin-on-human-ovarian-cancer-cells-skov-3-and-a2780
#1
J Huo, X-H Bian, Y Huang, Z-C Miao, L-H Song
OBJECTIVE: Ovarian cancer is the most common malignant tumor in female reproductive system. Metformin is an orally taken hypoglycemic agent, which is extensively applied in the clinic. Clinical trials find that there may be a certain degree of action of the metformin in inhibiting malignant tumors. This paper aims to investigate the inhibitory effect and mechanism of metformin on human ovarian cancer cells. MATERIALS AND METHODS: Through in vitro cell experiment, the influences of metformin on the proliferation, colony formation and apoptosis of ovarian carcinoma cells were studied...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239814/microrna15b-induced-smcc7721-apoptosis-via-down-regulation-of-xiap
#2
W-B Ding, Y-X Wang, C-W Dong
OBJECTIVE: microRNA can regulate cell growth, proliferation, and death; also, it can promote or inhibit cell growth and proliferation through regulation of apoptotic proteins. XIAP is a newly discovered pro-apoptotic protein, but how is XIAP regulated remains unclear. This study investigated the role of microRNA-15b in liver cancer cells' proliferation and apoptosis. MATERIALS AND METHODS: microRNA15b and control microRNA (miRNA) were purchased and transfected with hepatoma SMCC7721 cells using liposomal transfection techniques...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239804/arsenic-trioxide-regulates-gastric-cancer-cell-apoptosis-by-mediating-camp
#3
A Abudoureyimu, A Muhemaitibake
OBJECTIVE: Gastric cancer is a common digestive tract tumor in clinic with increasing incidence. It is suggested that arsenic trioxide (As2O3) has an inhibitory effect on many kinds of digestive system tumors. This study evaluated the impact of As2O3 on the apoptosis of gastric cancer BGC-823 cells, and analyzed its relationship with cyclic adenosine monophosphate (cAMP). MATERIALS AND METHODS: Gastric cancer cell BGC-823 was intervened by different concentrations of As2O3 at 4 ng/ml, 8 ng/ml, and 16 ng/ml, respectively...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239766/up-regulation-of-gbp2-is-associated-with-neuronal-apoptosis-in-rat-brain-cortex-following-traumatic-brain-injury
#4
Qi Miao, Meihong Ge, Lili Huang
Guanylate binding protein 2 (GBP2) is one member of GBP family. Recently, GBP2 has been proposed to be a novel target of anti-cancer drugs. However, the role of GBP2 in the traumatic brain injury (TBI) is very limited. In this study, we sought to define GBP2's role in brain injury. GBP2 protein levels were significantly increased in the brain 3 days after injury, suggesting a functional role for GBP2 in TBI. Neuronal cells overexpressing GBP2 exhibited up-regulation of co-location of GBP2 and NeuN following TBI, suggesting that GBP2 potentiates the neuron apoptosis...
February 27, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28239299/synthetic-curcumin-derivative-dk1-possessed-g2-m-arrest-and-induced-apoptosis-through-accumulation-of-intracellular-ros-in-mcf-7-breast-cancer-cells
#5
Norlaily Mohd Ali, Swee Keong Yeap, Nadiah Abu, Kian Lam Lim, Huynh Ky, Ahmad Zaim Mat Pauzi, Wan Yong Ho, Sheau Wei Tan, Han Kiat Alan-Ong, Seema Zareen, Noorjahan Banu Alitheen, M Nadeem Akhtar
AIMS: Curcumin is a lead compound of the rhizomes of Curcuma longa and possess a broad range of pharmacological activities. Chemically, curcumin is 1,3-dicarbonyl class of compound, which exhibits keto-enol tautomerism. Despite of its strong biological properties, curcumin has yet been recommended as a therapeutic agent because of its poor bioavailability. MAIN METHODS: A curcumin derivative (Z)-3-hydroxy-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (DK1) was synthesized and its cytotoxicity was tested on breast cancer cell MCF-7 and normal cell MCF-10A using MTT assay...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28239297/up-regulation-of-crkl-by-microrna-335-methylation-is-associated-with-poor-prognosis-in-gastric-cancer
#6
Jia-Kui Zhang, Yong-Shuang Li, Chun-Dong Zhang, Dong-Qiu Dai
BACKGROUND: MicroRNAs have been suggested to play a vital role in regulating carcinogenesis, tumor progression and invasion. MiR-335 is involved in suppressing metastasis and invasion in various human cancers. However, the mechanisms responsible for the aberrant expression of miR-335 in gastric cancer (GC) remain unknown. METHODS: Expression of miR-335 in four GC cell lines and 231 GC tissues was determined by real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR)...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28238856/gemcitabine-kills-proliferating-endothelial-cells-exclusively-via-acid-sphingomyelinase-activation
#7
Albert J van Hell, Adriana Haimovitz-Friedman, Zvi Fuks, William D Tap, Richard Kolesnick
Gemcitabine is a widely-used anti-cancer drug with a well-defined mechanism of action in normal and transformed epithelial cells. However, its effect on endothelial cells is largely unknown. Acid sphingomyelinase (ASMase) is highly expressed in endothelial cells, converting plasma membrane sphingomyelin to pro-apoptotic ceramide upon activation by diverse stresses. In the current study, we investigated gemcitabine impact in primary cultures of endothelial cells. We find baseline ASMase increases markedly in bovine aortic endothelial cells (BAEC) as they transit from a proliferative to a confluent growth-arrested state...
February 23, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28238782/vaccination-efficacy-with-marrow-mesenchymal-stem-cell-against-cancer-was-enhanced-under-simulated-microgravity
#8
Jing Li, Jun Chen, Xiuyu Li, Yanfang Qian
Stem cell vaccination can induce consistent and strong anti-tumor immunity against cancer in mice model. The antigenic similarity between tumors and embryos has been appreciated for many years and reflects the expression of embryonic gene products by cancer cells and/or cancer-initiating stem cells. Taking advantage of this similarity, we have tested a prophylactic lung cancer vaccine composed of allogeneic murine MSCs. Based on this conception, we first compared their tumor vaccines intervention effects of adult MSCs and MSCs under simulated microgravity (MSC/SMG)...
February 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28237877/osimertinib-induces-autophagy-and-apoptosis-via-reactive-oxygen-species-generation-in-non-small-cell-lung-cancer-cells
#9
Zheng-Hai Tang, Wen-Xiang Cao, Min-Xia Su, Xiuping Chen, Jin-Jian Lu
Osimertinib (OSI), also known as AZD9291, is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that has been approved for the treatment of non-small cell lung cancer (NSCLC) patients harboring EGFR T790M mutation. Herein, we indicated for the first time that OSI increased the accumulations of cytoplasmic vacuoles, the expression of phosphatidylethanolamine-modified microtubule-associated protein light-chain 3 (LC3-II), and the formation of GFP-LC3 puncta in various cancer cells...
February 22, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28237794/combination-of-amino-acid-dipeptide-with-ligustrazine-betulinic-acid-as-antitumor-agents
#10
Bing Xu, Wen-Qiang Yan, Xin Xu, Gao-Rong Wu, Chen-Ze Zhang, Yao-Tian Han, Fu-Hao Chu, Rui Zhao, Peng-Long Wang, Hai-Min Lei
The lead compound TBA, 3β-Hydroxy-lup-20(29)-ene-28-oic acid-3, 5, 6-trimethylpyrazin-2-methyl ester, which exhibited promising antitumor activity and induced tumor cell apoptosis in various cancer cell lines, had previously been reported. Moreover, reports have revealed that the introduction of amino acid to betulinic acid could improve selective cytotoxicity as well as water solubility. Thus, a series of novel TBA amino acid and dipeptide derivatives were designed, synthesized and screened for selective cytotoxic activity against five cancer cell lines (HepG2, HT-29, Hela, BCG-823 and A549) and the not malignant cell line MDCK by standard MTT assay...
February 17, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28237792/facile-and-efficient-access-to-androsten-17-1-3-4-pyrazoles-and-androst-17%C3%AE-1-3-4-pyrazoles-via-vilsmeier-reagents-and-their-antiproliferative-activity-evaluation-in%C3%A2-vitro
#11
Jian Li, Haibo Huo, Rui Guo, Biao Liu, Longbo Li, Wenjia Dan, Xinmin Xiao, Jiwen Zhang, Baojun Shi
In this work, twenty-seven novel steroidal pyrazole derivatives were designed and effectively synthesized with two different commercially available staring material, Isopregnanolone 1 and 5,16-Pregnadienolone 7, via the key intermediates, 17β-(4'-formyl)pyrazolylandrost-3β-yl formate and 17-(4'-formyl)pyrazolylandrost- 5,16-dienes-3β-yl formate, which were obtained from the cyclization of steroidal phenylhydrazone with Vilsmeier reagent catalyzed by phosphorous oxychloride followed by hydrolysis, then Borch reduction to afford the target derivatives under mild conditions...
February 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28237749/redox-sensitive-self-assembled-nanoparticles-based-on-alpha-tocopherol-succinate-modified-heparin-for-intracellular-delivery-of-paclitaxel
#12
Xiaoye Yang, Xiaoqing Cai, Aihua Yu, Yanwei Xi, Guangxi Zhai
To remedy the problems riddled in cancer chemotherapy, such as poor solubility, low selectivity, and insufficient intra-cellular release of drugs, novel heparin-based redox-sensitive polymeric nanoparticles were developed. The amphiphilic polymer, heparin-alpha-tocopherol succinate (Hep-cys-TOS) was synthesized by grafting hydrophobic TOS to heparin using cystamine as the redox-sensitive linker, which could self-assemble into nanoparticles in phosphate buffer saline (PBS) with low critical aggregation concentration (CAC) values ranging from 0...
February 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28237650/inhibition-and-inactivation-of-human-cyp2j2-implications-in-cardiac-pathophysiology-and-opportunities-in-cancer-therapy
#13
REVIEW
Aneesh Karkhanis, Yanjun Hong, Eric Chun Yong Chan
Extrahepatic cytochrome P450 enzymes (CYP450) are pivotal in the metabolism of endogenous substrates and xenobiotics. CYP2J2 is a major cardiac CYP450 and primarily metabolizes polyunsaturated fatty acids such as arachidonic acid to cardioactive epoxyeicosatrienoic acids. Due to its role in endobiotic metabolism, CYP2J2 has been actively studied in recent years with the focus on its biological functions in cardiac pathophysiology. Additionally, CYP2J2 metabolizes a number of xenobiotics such as astemizole and terfenadine and is potently inhibited by danazol and telmisartan...
February 22, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28237487/hsp70-inhibitor-combined-with-cisplatin-suppresses-the-cervical-cancer-proliferation-in%C3%A2-vitro-and-transplanted-tumor-growth-an-experimental-study
#14
Jian Liu, Jing Liu, Su-Yang Guo, Hong-Li Liu, Sheng-Ze Li
OBJECTIVE: To study the regulating effect of HSP70 inhibitor (PES) combined with cisplatin on cervical cancer proliferation in vitro and transplanted tumor growth. METHODS: Cervical cancer Hela cell lines were cultured and divided into control group, cisplatin group, PES group and cisplatin + PES group that were treated with serum-free DMEM, cisplatin with final concentration of 10 μmol/L, PES 20 μmol/L and cisplatin 10 μmol/L combined with PES with 20 μmol/L, respectively; animal models with cervical cancer xenografts were established and divided into control group, cisplatin group, PES group and cisplatin + PES group who received intra-tumor injection of normal saline, 10 μmol/L cisplatin, 20 μmol/L PES as well as 10 μmol/L cisplatin + 20 μmol/L PES, respectively...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28237486/targeted-inhibition-of-notch1-gene-enhances-the-killing-effects-of-paclitaxel-on-triple-negative-breast-cancer-cells
#15
Yu-Fu Zhou, Qian Sun, Ya-Jun Zhang, Geng-Ming Wang, Bin He, Tao Qi, Yan Zhou, Xing-Wang Li, Sheng Li, Lin He
OBJECTIVE: To study the influence of targeted inhibition of Notch1 gene on the killing effects of paclitaxel on triple negative breast cancer cells. METHODS: The triple negative [estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (Her2)] breast cancer cell line MDA-MB-231 and ER/PR/HER-2-positive breast cancer cell line MCF-7 were cultured, transfected with Notch1-siRNA-overexpression plasmid and blank plasmid, and treated with different concentrations of paclitaxel, and then the cell proliferation activity and apoptosis rate as well as the mRNA expression of Caspase-3, Caspase-9 and Bcl-2 were determined...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28236767/triggering-autophagic-cell-death-with-a-di-manganese-ii-developmental-therapeutic
#16
Creina Slator, Zara Molphy, Vickie McKee, Andrew Kellett
There is an unmet need for novel metal-based chemotherapeutics with alternative modes of action compared to clinical agents such as cisplatin and metallo-bleomycin. Recent attention in this field has focused on designing intracellular ROS-mediators as powerful cytotoxins of human cancers and identifying potentially unique toxic mechanisms underpinning their utility. Herein, we report the developmental di-manganese(II) therapeutic [Mn2(μ-oda)(phen)4(H2O)2][Mn2(μ-oda)(phen)4(oda)2]·4H2O (Mn-Oda) induces autophagy-promoted apoptosis in human ovarian cancer cells (SKOV3)...
February 4, 2017: Redox Biology
https://www.readbyqxmd.com/read/28236701/an-alternative-poldip3-transcript-promotes-hepatocellular-carcinoma-progression
#17
Xiao-Ning Liu, Ji-Hang Yuan, Tian-Tian Wang, Wei Pan, Shu-Han Sun
Alternative splicing plays critical roles in many pathophysiological processes and splicing dysregulation is a hallmark of cancer. The different isoforms may have significantly different effects on cancers. POLDIP3 is a target of ribosomal protein S6 kinase 1, and regulates DNA replication and mRNA translation. In this study, we measured the expression of an alternative POLDIP3 transcript (POLDIP3-β), which lacks exon 3 and 29 amine acids, in clinical hepatocellular carcinoma (HCC) tissues. The roles of POLDIP3-β on HCC cell proliferation, apoptosis, and migration were assessed by Glo cell viability assays, Ethynyl deoxyuridine incorporation assays, colony formation assays, TUNEL assays, Annexin V-propidium iodide staining and flow cytometry, transwell assays, wound healing assays, and in vivo xenograft growth...
February 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28236685/conjugation-of-chlorins-with-spermine-enhances-phototoxicity-to-cancer-cells-in-vitro
#18
Mariia Darmostuk, Michal Jurášek, Kamila Lengyel, Jaroslav Zelenka, Michaela Rumlová, Pavel Drašar, Tomáš Ruml
Photodynamic therapy (PDT) is one of the most promising methods of specific cancer treatment. However, commercially available photosensitizers (PSs) show significant drawbacks, such as side toxicity, low penetration ability, low blood solubility, low tumor selectivity etc. In addition, as was shown previously, a conjugation of polyamines with several toxic agents led to an increased toxicity to cancer cells. Here, we synthesized conjugates of two chlorine photosensitizers, purpurin 18 and pheophorbide a, with spermine in natural and Boc-protected form...
February 17, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28236621/proapoptotic-and-growth-inhibitory-effects-of-plumbagin-on-human-gastric-cancer-cells-via-suppression-of-signal-transducer-and-activator-of-transcription-3-and-protein-kinase-b
#19
Jing Li, Jia Li, Guowei Cai, Lin Shen, Furong Lu
Context • Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer-related deaths in the world. The current treatments include surgery and chemotherapy, either alone or in combination with radiotherapy, but the prognosis for patients with GC is usually poor. A safe and effective chemopreventive treatment for this malignant disease is urgently needed. Objective • The study intended to investigate the effects and underlying mechanisms of plumbagin, a quinonoid constituent that is derived from the roots of the medicinal plant Plumbago zeylanica, which exhibits potent anticancer properties against a number of cancers...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28236592/novel-conjugates-of-endoperoxide-and-4-anilinoquinazoline-as-potential-anticancer-agents
#20
Jing Yang, Zhengchao Tu, Xin Xu, Jinfeng Luo, Xing Yan, Chongzhao Ran, Xinliang Mao, Ke Ding, Chunhua Qiao
In the present study, endoperoxide and 4-anilinoqnazoline were conjugated to obtain a series of compounds. These conjugates exhibited high antiproliferative potency against a number of cancer cell lines, including the epidermal growth factor receptor (EGFR) L858R/T790M mutant cell. Compound 5 was selected as a representative for mechanistic study. Further experiments revealed the conjugate's reactive oxygen species (ROS) generating ability, apoptosis inducing activity and involvement in EGFR downstream signaling pathways...
February 13, 2017: Bioorganic & Medicinal Chemistry Letters
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