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Shear Stress AND Cancer

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https://www.readbyqxmd.com/read/29717355/the-function-of-trp-channels-in-neutrophil-granulocytes
#1
REVIEW
Karolina Najder, Boris Musset, Otto Lindemann, Etmar Bulk, Albrecht Schwab, Benedikt Fels
Neutrophil granulocytes are exposed to widely varying microenvironmental conditions when pursuing their physiological or pathophysiological functions such as fighting invading bacteria or infiltrating cancer tissue. Examples for harsh environmental challenges include among others mechanical shear stress during the recruitment from the vasculature or the hypoxic and acidotic conditions within the tumor microenvironment. Chemokine gradients, reactive oxygen species, pressure, matrix elasticity, and temperature can be added to the list of potential challenges...
May 1, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29678550/low-level-shear-stress-promotes-migration-of-liver-cancer-stem-cells-via-the-fak-erk1-2-signalling-pathway
#2
Jinghui Sun, Qing Luo, Lingling Liu, Guanbin Song
Cancer stem cells (CSCs) are a small subpopulation of tumour cells that have been proposed to be responsible for cancer initiation, chemotherapy resistance and cancer recurrence. Shear stress activated cellular signalling is involved in cellular migration, proliferation and differentiation. However, little is known about the effects of shear stress on the migration of liver cancer stem cells (LCSCs). Here, we studied the effects of shear stress that are generated from a parallel plated flow chamber system, on LCSC migration and the activation of focal adhesion kinase (FAK) and extracellular signal regulated kinase1/2 (ERK1/2), using transwell assay and western blot, respectively...
April 17, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29629709/modeling-cell-substrate-de-adhesion-dynamics-under-fluid-shear
#3
Renu Maan, Garima Rani, Gautam I Menon, Pramod A Pullarkat
Changes in cell-substrate adhesion are believed to signal the onset of
 cancer metastasis, but such changes must be quantified against background levels of
 intrinsic heterogeneity between cells. Intrinsic variations in cell-substrate adhesion
 strengths can be probed through biophysical measurements of cell detachment from
 substrates upon the application of an external force. Here, we investigate, theoretically
 and experimentally, the detachment of cells adhered to substrates when these cells are
 subjected to the fluid shear...
April 9, 2018: Physical Biology
https://www.readbyqxmd.com/read/29566010/fluid-shear-stress-impacts-ovarian-cancer-cell-viability-subcellular-organization-and-promotes-genomic-instability
#4
Alexandra R Hyler, Nicolaas C Baudoin, Megan S Brown, Mark A Stremler, Daniela Cimini, Rafael V Davalos, Eva M Schmelz
Ovarian cancer cells are exposed to physical stress in the peritoneal cavity during both tumor growth and dissemination. Ascites build-up in metastatic ovarian cancer further increases the exposure to fluid shear stress. Here, we used a murine, in vitro ovarian cancer progression model in parallel with immortalized human cells to investigate how ovarian cancer cells of increasing aggressiveness respond to [Formula: see text] of fluid-induced shear stress. This biophysical stimulus significantly reduced cell viability in all cells exposed, independent of disease stage...
2018: PloS One
https://www.readbyqxmd.com/read/29541636/feeling-stress-the-mechanics-of-cancer-progression-and-aggression
#5
REVIEW
Josette M Northcott, Ivory S Dean, Janna K Mouw, Valerie M Weaver
The tumor microenvironment is a dynamic landscape in which the physical and mechanical properties evolve dramatically throughout cancer progression. These changes are driven by enhanced tumor cell contractility and expansion of the growing tumor mass, as well as through alterations to the material properties of the surrounding extracellular matrix (ECM). Consequently, tumor cells are exposed to a number of different mechanical inputs including cell-cell and cell-ECM tension, compression stress, interstitial fluid pressure and shear stress...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29536225/hemodynamic-shear-stress-induces-protective-autophagy-in-hela-cells-through-lipid-raft-mediated-mechanotransduction
#6
Joyjyoti Das, Somnath Maji, Tarun Agarwal, Suman Chakraborty, Tapas K Maiti
During metastatic dissemination, cancer cells experience shear stresses in narrow confinements of in vivo vasculature. Such stresses are currently known to influence a gamut of cellular processes. While a host of cells emanating from a primary tumor perish in circulation due to shear, some cells manage to migrate to distant niches and form secondary tumors. Current research focuses on how cancer cells avert such mechanical stresses and adapt themselves in order to survive. This study deals with the autophagic response of cervical cancer cells HeLa and its subline HeLa 229, exposed to physiological shear stresses in vitro, and evaluates its role as a pro-survival mechanism...
March 13, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29520361/beyond-enumeration-functional-and-computational-analysis-of-circulating-tumor-cells-to-investigate-cancer-metastasis
#7
REVIEW
Francesc Castro-Giner, Manuel C Scheidmann, Nicola Aceto
Circulating tumor cells (CTCs) are defined as those cells that detach from a cancerous lesion and enter the bloodstream. While generally most CTCs are subjected to high shear stress, anoikis signals, and immune attack in the circulatory system, few are able to survive and reach a distant organ in a viable state, possibly leading to metastasis formation. A large number of studies, both prospective and retrospective, have highlighted the association between CTC abundance and bad prognosis in patients with various cancer types...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29414985/the-quaternary-state-of-polymerized-human-hemoglobin-regulates-oxygenation-of-breast-cancer-solid-tumors-a-theoretical-and-experimental-study
#8
Donald A Belcher, Julia A Ju, Jin Hyen Baek, Ayla Yalamanoglu, Paul W Buehler, Daniele M Gilkes, Andre F Palmer
A major constraint in the treatment of cancer is inadequate oxygenation of the tumor mass, which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human hemoglobin (PolyhHb) can be transfused into the systemic circulation to increase solid tumor oxygenation, and improve chemotherapeutic outcomes. By locking PolyhHb in the relaxed (R) quaternary state, oxygen (O2) offloading at low O2 tensions (<20 mm Hg) may be increased, while O2 offloading at high O2 tensions (>20 mm Hg) is facilitated with tense (T) state PolyhHb...
2018: PloS One
https://www.readbyqxmd.com/read/29363599/human-bone-perivascular-niche-on-a-chip-for-studying-metastatic-colonization
#9
Alessandro Marturano-Kruik, Michele Maria Nava, Keith Yeager, Alan Chramiec, Luke Hao, Samuel Robinson, Edward Guo, Manuela Teresa Raimondi, Gordana Vunjak-Novakovic
Eight out of 10 breast cancer patients die within 5 years after the primary tumor has spread to the bones. Tumor cells disseminated from the breast roam the vasculature, colonizing perivascular niches around blood capillaries. Slow flows support the niche maintenance by driving the oxygen, nutrients, and signaling factors from the blood into the interstitial tissue, while extracellular matrix, endothelial cells, and mesenchymal stem cells regulate metastatic homing. Here, we show the feasibility of developing a perfused bone perivascular niche-on-a-chip to investigate the progression and drug resistance of breast cancer cells colonizing the bone...
February 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29278411/perfusion-applied-to-a-3d-model-of-bone-metastasis-results-in-uniformly-dispersed-mechanical-stimuli
#10
Boyuan Liu, Suyue Han, Brandon P Hedrick, Yahya Modarres-Sadeghi, Maureen E Lynch
Breast cancer most frequently metastasizes to the skeleton. Bone metastatic cancer is incurable and induces wide-spread bone osteolysis, resulting in significant patient morbidity and mortality. Mechanical cues in the skeleton are an important microenvironmental parameter that modulate tumor formation, osteolysis, and tumor cell-bone cell signaling, but which mechanical signals are the most beneficial and the corresponding molecular mechanisms are unknown. We focused on interstitial fluid flow based on its well-known role in bone remodeling and in primary breast cancer...
April 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29273839/laminar-shear-stress-inhibits-high-glucose-induced-migration-and-invasion-in-human-bladder-cancer-cells
#11
Yu-Hsiang Lee, Chien-Hsuan Yeh
High glucose has been known to play a pathogenic role in the development and progression of bladder cancer in diabetics, whereas the leading cause of death in such patients is mainly attributed to hyperglycemia-enhanced metastasis. In addition to the impact of glucose, cancer cells may be affected by laminar shear stress (LSS) generated from interstitial, blood, and/or lymphatic fluid flows during metastasis. Although the effect of flow-induced mechanical force on cancer pathophysiology has been extensively investigated, very little is understood regarding the cells that are simultaneously stimulated by LSS and hyperglycemia...
February 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29150280/nk-cell-recruitment-and-exercise-potential-immunotherapeutic-role-of-shear-stress-and-endothelial-health
#12
William Evans
Positive cancer patient outcomes, including increased time to recurrent events, have been associated with increased counts and function of natural killer (NK) cells. NK cell counts and function are elevated following acute exercise, and the generally accepted mechanism of increased recruitment suggests that binding of epinephrine releases NK cells from endothelial tissue via decreases in adhesion molecules following. I propose that blood flow-induced shear stress may also play a role in NK cell recruitment from the endothelium...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29143545/taz-responds-to-fluid-shear-stress-to-regulate-the-cell-cycle
#13
Hyun Jung Lee, Adesuwa Ewere, Miguel F Diaz, Pamela L Wenzel
Physical forces associated with tumor growth and drainage alter cancer cell invasiveness and metastatic potential. We previously showed that fluid frictional force, or shear stress, typical of lymphatic flow induces YAP1/TAZ activation in prostate cancer cells to promote motility dependent upon YAP1 but not TAZ. Here, we show that shear stress elevates TAZ protein levels and promotes TAZ nuclear localization. Increased TAZ activity drives increased DNA synthesis and induces AMOTL2, ANKRD1, and CTGF gene transcription independently of YAP1...
November 16, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29138312/correlating-cell-shape-and-cellular-stress-in-motile-confluent-tissues
#14
Xingbo Yang, Dapeng Bi, Michael Czajkowski, Matthias Merkel, M Lisa Manning, M Cristina Marchetti
Collective cell migration is a highly regulated process involved in wound healing, cancer metastasis, and morphogenesis. Mechanical interactions among cells provide an important regulatory mechanism to coordinate such collective motion. Using a self-propelled Voronoi (SPV) model that links cell mechanics to cell shape and cell motility, we formulate a generalized mechanical inference method to obtain the spatiotemporal distribution of cellular stresses from measured traction forces in motile tissues and show that such traction-based stresses match those calculated from instantaneous cell shapes...
November 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29137378/trastuzumab-distribution-in-an-in-vivo-and-in-vitro-model-of-brain-metastases-of-breast-cancer
#15
Tori B Terrell-Hall, Mohamed Ismail Nounou, Fatema El-Amrawy, Jessica I G Griffith, Paul R Lockman
Background: Drug and antibody delivery to brain metastases has been highly debated in the literature. The blood-tumor barrier (BTB) is more permeable than the blood-brain barrier (BBB), and has shown to have highly functioning efflux transporters and barrier properties, which limits delivery of targeted therapies. Methods: We characterized the permeability of125 I-trastuzumab in an in-vivo , and fluorescent trastuzumab-Rhodamine123 (t-Rho123) in a novel microfluidic in-vitro , BBB and BTB brain metastases of breast cancer model...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29069374/cellular-shear-stiffness-reflects-progression-of-arsenic-induced-transformation-during-g1
#16
Alexandra Muñoz, Will J Eldridge, Nina Munkholt Jakobsen, Helle Sørensen, Adam Wax, Max Costa
Cancer cells consistently exhibit decreased stiffness; however, the onset and progression of this change have not been characterized. To study the development of cell stiffness changes, we evaluated the shear stiffness of populations of cells during transformation to a carcinogenic state. Bronchial epithelial cells were exposed to sodium arsenite to initiate early stages of transformation. Exposed cells were cultured in soft agar to further transformation and select for clonal populations exhibiting anchorage-independent growth...
February 9, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29063816/stress-analysis-of-irradiated-human-tooth-enamel-using-finite-element-methods
#17
Ganesh Thiagarajan, Bruno Vizcarra, Venkata Bodapudi, Rachel Reed, Rasoul Seyedmahmoud, Yong Wang, Jeffrey P Gorski, Mary P Walker
The objectives of this project were to use finite element methods to determine how changes in the elastic modulus due to oral cancer therapeutic radiation alter the distribution of mechanical stresses in teeth and to determine if observed failures in irradiated teeth correlate with changes in mechanical stresses. A thin slice section finite element (FE) model was constructed from micro CT sections of a molar tooth using MIMICS and 3-Matic software. This model divides the tooth into three enamel regions, the dentin-enamel junction (DEJ) and dentin...
November 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/29034587/open-fluidics-a-cell-culture-flow-system-developed-over-wettability-contrast-based-chips
#18
Nuno M Oliveira, Rui L Reis, João F Mano
Biological tissues are recurrently exposed to several dynamic mechanical forces that influence cell behavior. On this work, the focus is on the shear stress forces induced by fluid flow. The study of flow-induced effects on cells leads to important advances in cardiovascular, cancer, stem cell, and bone biology understanding. These studies are performed using cell culture flow (CCF) systems, mainly parallel plate flow chambers (PPFC), and microfluidic systems. Here, it is proposed an original CCF system based on the open fluidics concept...
December 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28951564/mechanobiology-of-yap-and-taz-in-physiology-and-disease
#19
REVIEW
Tito Panciera, Luca Azzolin, Michelangelo Cordenonsi, Stefano Piccolo
A growing body of evidence suggests that mechanical signals emanating from the cell's microenvironment are fundamental regulators of cell behaviour. Moreover, at the macroscopic scale, the influence of forces, such as the forces generated by blood flow, muscle contraction, gravity and overall tissue rigidity (for example, inside of a tumour lump), is central to our understanding of physiology and disease pathogenesis. Still, how mechanical cues are sensed and transduced at the molecular level to regulate gene expression has long remained enigmatic...
December 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28837150/three-dimensional-tumor-cell-growth-stimulates-autophagic-flux-and-recapitulates-chemotherapy-resistance
#20
Corinna Bingel, Emily Koeneke, Johannes Ridinger, Annika Bittmann, Martin Sill, Heike Peterziel, Jagoda K Wrobel, Inga Rettig, Till Milde, Uta Fernekorn, Frank Weise, Andreas Schober, Olaf Witt, Ina Oehme
Current preclinical models in tumor biology are limited in their ability to recapitulate relevant (patho-) physiological processes, including autophagy. Three-dimensional (3D) growth cultures have frequently been proposed to overcome the lack of correlation between two-dimensional (2D) monolayer cell cultures and human tumors in preclinical drug testing. Besides 3D growth, it is also advantageous to simulate shear stress, compound flux and removal of metabolites, e.g., via bioreactor systems, through which culture medium is constantly pumped at a flow rate reflecting physiological conditions...
August 24, 2017: Cell Death & Disease
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