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https://www.readbyqxmd.com/read/28813450/oral-microbial-community-assembly-under-the-influence-of-periodontitis
#1
Hongju Chen, Shuting Peng, Lin Dai, Quan Zou, Bin Yi, Xianghong Yang, Zhanshan Sam Ma
Several ecological hypotheses (e.g., specific plaque, non-specific plaque and keystone pathogen) regarding the etiology of periodontitis have been proposed since the 1990s, most of which have been centered on the concept of dysbiosis associated with periodontitis. Nevertheless, none of the existing hypotheses have presented mechanistic interpretations on how and why dysbiosis actually occurs. Hubbell's neutral theory of biodiversity offers a powerful null model to test hypothesis regarding the mechanism of community assembly and diversity maintenance from the metagenomic sequencing data, which can help to understand the forces that shape the community dynamics such as dysbiosis...
2017: PloS One
https://www.readbyqxmd.com/read/28810949/analysis-of-non-pivotal-bioequivalence-studies-submitted-in-abbreviated-new-drug-submissions-for-delayed-release-drug-products
#2
Paramjeet Kaur, Xiaojian Jiang, Ethan Stier
The US FDA's rule on "Requirements for Submission of Bioequivalence Data" requiring submission of all bioequivalence (BE) studies conducted on the same formulation of the drug product submitted for approval was published in Federal Register in January 2009. With the publication of this rule, we evaluated the impact of data from non-pivotal BE studies in assessing BE and identified the reasons for failed in vivo BE studies for generic oral delayed-release (DR) drug products only. We searched the Agency databases from January 2009 toDecember 2016 to identify Abbreviated New Drug Applications (ANDAs) submitted for DR drug products containing non-pivotal BE studies...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28809759/independent-dose-verification-system-with-monte-carlo-simulations-using-topas-for-passive-scattering-proton-therapy-at-the-national-cancer-center-in-korea
#3
Wook-Geun Shin, Mauro Testa, Hak Soo Kim, Jong Hwi Jeong, Se Byeong Lee, Yeon-Joo Kim, Chul Hee Min
For the independent validation of treatment plans, we developed a Monte Carlo (MC)-based patient dose calculation system with the tool for particle simulation (TOPAS) to enable routine and automatic dose recalculation for each patient. The proton beam nozzle was modeled with TOPAS to simulate the therapeutic beam, and MC commissioning was performed by comparing percent depth dose with the measurement. The beam set-up based on the prescribed beam range and modulation width was automated by modifying the vendor-specific method...
August 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28808766/water-penetration-of-grommets-an-in-vitro-study
#4
Yousef Ibrahim, Paul Fram, Gavin Hughes, Pete Phillips, David Owens
The insertion of grommets has been one of the most common procedures carried out by ENT surgeons for patients with persistent middle ear fluid. There has always been apprehension at the use of grommets by patients undertaking swimming or other water sports due to concerns of grommet penetration by water into the middle ear. Despite this, no common consensus exists amongst otolaryngologists regarding post-operative advice following grommet insertion. Most studies focus on surface swimming and do not consider other activities such as diving that patients may undertake...
August 14, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28808251/continuous-production-of-macroporous-films-an-alternative-to-breath-figure-assembly
#5
Nazia Noor, Joachim Koll, Clarissa Abetz, Heiko Notzke, Volker Abetz
Despite the need for sophisticated instrumentation, breath figure assembly (BFA) methods are restricted to produce macroporous films on a tiny scale so far. The current study narrates the fabrication of macroporous films in hollow fiber geometry which extends to adopt the method for continuous production of isoporous surfaces from commercially available low-priced polymer materials. The fabrication of the films in the hollow fiber geometry is carried out by a co-centric quadruple orifice spinneret through which four different liquids are co-extruded simultaneously: bore fluid (to fill the lumen of the fiber), support layer solution, glycerol, and an isoporous film forming solution through the outer most orifice...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28804698/a-novel-technique-of-posterolateral-suturing-in-thoracoscopic-diaphragmatic-hernia-repair
#6
Yoon Jung Boo, Stephan Rohleder, Oliver J Muensterer
Background  Closure of the posterolateral defect in some cases of congenital diaphragmatic hernia (CDH) can be difficult. Percutaneous transcostal suturing is often helpful to create a complete, watertight closure of the diaphragm. A challenge with the technique is passing the needle out the same tract that it entered so that no skin is caught when the knots are laid down into the subcutaneous tissue. This report describes a novel technique using a Tuohy needle to percutaneously suture the posterolateral defect during thoracoscopic repair of CDH...
January 2017: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/28804642/e-learning-for-medical-imaging-specialists-introducing-blended-learning-in-a-nuclear-medicine-specialist-course
#7
Torjan Haslerud, Andreas Julius Tulipan, Robert M Gray, Martin Biermann
BACKGROUND: While e-learning has become an important tool in teaching medical students, the training of specialists in medical imaging is still dominated by lecture-based courses. PURPOSE: To assess the potential of e-learning in specialist education in medical imaging. MATERIAL AND METHODS: An existing lecture-based five-day course in Clinical Nuclear Medicine (NM) was enhanced by e-learning resources and activities, including practical exercises...
July 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28801741/scleral-suture-fixation-technique-for-dislocated-plate-haptic-toric-iol
#8
Remzi Karadag, Bahar Gunes, Veysel Aykut, Halit Oguz, Ahmet Demirok
Purpose We describe a scleral suture fixation technique for dislocated plate haptic toric intraocular lens (IOL) implantation. Materials and methods A double-armed 10-0 straight polypropylene suture was passed into the eye from the sclera (2 mm away from the limbus). A suture needle was passed through the hole on the corner of the IOL and pulled out from the paracentesis with a 27-gauge needle. Afterward, the suture needle was reinserted from the same paracentesis and then removed from the eye with the help of a 27-gauge needle entering the eye from a nearby point to the first scleral entrance...
August 11, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28800632/radar-a-novel-fast-screening-method-for-reading-difficulties-with-special-focus-on-dyslexia
#9
Ioannis Smyrnakis, Vassilios Andreadakis, Vassilios Selimis, Michail Kalaitzakis, Theodora Bachourou, Georgios Kaloutsakis, George D Kymionis, Stelios Smirnakis, Ioannis M Aslanides
Dyslexia is a developmental learning disorder of single word reading accuracy and/or fluency, with compelling research directed towards understanding the contributions of the visual system. While dyslexia is not an oculomotor disease, readers with dyslexia have shown different eye movements than typically developing students during text reading. Readers with dyslexia exhibit longer and more frequent fixations, shorter saccade lengths, more backward refixations than typical readers. Furthermore, readers with dyslexia are known to have difficulty in reading long words, lower skipping rate of short words, and high gaze duration on many words...
2017: PloS One
https://www.readbyqxmd.com/read/28795576/proximity-band-structure-and-spin-textures-on-both-sides-of-topological-insulator-ferromagnetic-metal-interface-and-their-charge-transport-probes
#10
Juan Manuel Marmolejo-Tejada, Kapildeb Dolui, Predrag Lazić, Po-Hao Chang, Søren Smidstrup, Daniele Stradi, Kurt Stokbro, Branislav K Nikolić
The control of recently observed spintronic effects in topological-insulator/ferromagnetic-metal (TI/FM) heterostructures is thwarted by the lack of understanding of band structure and spin textures around their interfaces. Here we combine density functional theory with Green's function techniques to obtain the spectral function at any plane passing through atoms of Bi2Se3 and Co or Cu layers comprising the interface. Instead of naively assumed Dirac cone gapped by the proximity exchange field spectral function, we find that the Rashba ferromagnetic model describes the spectral function on the surface of Bi2Se3 in contact with Co near the Fermi level EF(0), where circular and snowflake-like constant energy contours coexist around which spin locks to momentum...
August 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/28795511/a-sequential-case-series-of-23-intubations-in-a-rural-emergency-department-in-new-zealand
#11
Eleanor Powell, Hatem Alkhouri, Sally McCarthy, John Mackenzie, Toby Fogg, John Vassiliadis, Chris Cresswell
OBJECTIVE: To describe the practice and procedure of emergency intubation in Whanganui Emergency Department, New Zealand and determine whether intubation can be carried out effectively in the rural setting. METHOD: A prospective observational study using the Australia and New Zealand Airway Registry proforma to collect data on the indication, lead intubator, first-pass success rate and peri-procedural complications. Data were also collected on whether a formal airway assessment was carried out and whether a checklist was used...
August 10, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/28791244/to-compare-the-efficacy-of-tamsulosin-and-alfuzosin-as-medical-expulsive-therapy-for-ureteric-stones
#12
Rikki Singal, Gaurav Bhatia, Amit Mittal, Samita Singal, Muzzafar Zaman
AIMS AND OBJECTIVES: This study aims to evaluate the efficacy of tamsulosin and alfuzosin for the distal ureteral stone. This study assessed the spontaneous passage and expulsion of the stone. MATERIALS AND METHODS: The study was conducted in the Department of Surgery at Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, from May 2013 to May 2014. A total number of 136 patients diagnosed as distal ureteric stone (US) of size <10 mm were included in this study...
July 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28783844/thinking-big
#13
Sean Price
Most public health measures languished in the 85th Texas Legislature, but those for mental health care stood out as a giant exception. Lawmakers passed more than a dozen bills aimed at improving mental health care. And at a time when most state budgets were slashed, funding for mental health care rose - by a lot.
August 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28782316/rediscovering-chirality-role-of-s-metoprolol-in-cardiovascular-disease-management
#14
Jagdish C Mohan, Siddharth N Shah, Sunny Chinchansurkar, Arindam Dey, Rishi Jain
BACKGROUND: The process of drug discovery and development today encompass a myriad of paths for bringing a new therapeutic molecule that has minimal adverse effects and of optimal use to the patient. Chirality was proposed in the direction of providing a purer and safer form of drug [Ex- cetrizine and levocetrizine]. Decades have passed since the introduction of this concept and numerous chiral molecules are in existence in therapeutics, yet somehow this concept has been ignored. This review aims to rediscover the ignored facts about chirality, its benefits and clear some common myths considering the example of S-Metoprolol in the management of Hypertension and other cardiovascular diseases...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28775255/an-analysis-of-signal-processing-algorithm-performance-for-cortical-intrinsic-optical-signal-imaging-and-strategies-for-algorithm-selection
#15
J A Turley, K Zalewska, M Nilsson, F R Walker, S J Johnson
Intrinsic Optical Signal (IOS) imaging has been used extensively to examine activity-related changes within the cerebral cortex. A significant technical challenge with IOS imaging is the presence of large noise, artefact components and periodic interference. Signal processing is therefore important in obtaining quality IOS imaging results. Several signal processing techniques have been deployed, however, the performance of these approaches for IOS imaging has never been directly compared. The current study aims to compare signal processing techniques that can be used when quantifying stimuli-response IOS imaging data...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774182/annals-express-the-prediction-of-haematocrit-in-dried-blood-spots-from-the-measurement-of-haemoglobin-using-commercially-available-sodium-lauryl-sulphate
#16
Gareth Richardson, David John Marshall, Brian G Keevil
BACKGROUND: When preparing dried blood spots (DBS), the haematocrit (Hct) can affect the ability of the blood to spread through the filter paper, thus resulting in varying quantities of sample being measured when fixed sub- punches of the DBS are taken. It may be important to predict the sample Hct to correct for volume differences. METHODS: Blood (10 µL) was applied to Perkin Elmer 226® paper. The samples (n=165) were allowed to dry for 24 hrs and the entire blood spots were cut out...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28768550/abuse-and-disrespect-in-childbirth-process-and-abortion-situation-in-latin-america-and-the-caribbean-systematic-review-protocol
#17
Sofia Madeira, Vicky Pileggi, João Paulo Souza
BACKGROUND: Studies show that a large number of women around the world have experienced situations of abuse, disrespect, abuse, and neglect during childbirth and/or abortion. This violence is a serious violation of the rights of women, especially because it is a period in which the woman is more physiologically, socially, and psychologically vulnerable. Although this type of violence is known, there is still no international consensus on the definition of such violence and its prevalence is not known...
August 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28767920/implementing-apportionment-strategy-to-identify-costs-in-a-multidisciplinary-clinic
#18
Renato Ribeiro Nogueira Ferraz, Anna Sofia Costa Neri, Estela Capelas Barbosa, Marcus Vinícius Cesso da Silva
Objective: To present the implementation of an apportionment strategy proportional to the productive areas of a multidisciplinary clinic, defining the minimum values to be passed monthly to health professionals who work there. Methods: A study of the clinic structure was carried out, in which the area of occupation of each service was defined. Later the cost was prorated, allocating a value to each room, proportional to the space occupied. Results: The apportionment implementation allowed the clinic managers to visualize the cost of each room, providing a value base for formation of a minimum amount necessary to be passed monthly to each professional, as a form of payment for rent of using their facilities...
April 2017: Einstein
https://www.readbyqxmd.com/read/28767265/professors-principals-and-textbooks-from-the-midwifery-school-in-zadar
#19
REVIEW
Jovan Maksimović, Marko Maksimović
Midwifery in Dalmatia was highly undeveloped at the beginning of the XIX century. The health report from 1813 suggested that there were only 48 midwives in the whole province, and none of them with a degree from the midwifery school. After abolishing the Central Schools ("Ecoles Centrales"), which were founded at the time of French reign, and which had the university range, the professors who stayed in Zadar continued their work and teaching in the Midwifery School, which was founded in 1820 according to the decision made by Emperor Franz I, and started working in 1821...
June 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/28764201/the-need-and-importance-of-incorporating-academic-research-results-in-to-the-curricula-of-ayurveda-in-india
#20
Janmejaya Samal, Ranjit Kumar Dehury
Every year a noticeable number of MD and PhD students pass out from various Ayurveda colleges across the country. Each of these Post Graduate (PG) and doctoral students do submit a research thesis as a part of fulfillment of their respective degrees. As on 01/04/2015 there were 98 PG Ayurveda colleges in India with an admission capacity of 2441 seats each year. Moreover many of the post graduate institutes provide doctoral level (PhD) education which is primarily involved with research thesis. Such meticulous research carried out under the supervision of an academic expert should not go in vein and hence the research findings need to be slotted in to the respective areas and disciplines of Ayurveda syllabus...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
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