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https://www.readbyqxmd.com/read/29352812/usefulness-of-a-visual-aid-in-achieving-optimal-positioning-for-spinal-anesthesia-a-randomized-trial
#1
Usha Gurunathan, Shakeel Meeran Kunju, Karen Elizabeth Hay, Sharyn van Alphen
BACKGROUND: Optimal patient positioning is perceived as an essential factor to increase the success of performing neuraxial blockade. The primary objective of this study was to evaluate the benefit of using a visual image in addition to verbal instructions in order to optimize positioning for spinal block. METHODS: This was a prospective randomized controlled trial on 85 adult patients undergoing lower limb joint replacements at a tertiary academic hospital. Group 1(n = 43) randomized to receive standardized verbal instructions; Group 2 (n = 42) received standardized verbal instructions in conjunction with visual aids to achieve positioning for spinal anesthesia...
January 20, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29349776/effect-of-palpable-vs-impalpable-cricothyroid-membranes-in-a-simulated-emergency-front-of-neck-access-scenario
#2
C F Pairaudeau, C Mendonca, C Hillermann, I Qazi, P A Baker, R E Hodgson, S Radhakrishna
The Difficult Airway Society 2015 guidelines recommend and describe in detail a surgical cricothyroidotomy technique for the can't intubate, can't oxygenate (CICO) scenario, but this can be technically challenging for anaesthetists with no surgical training. Following a structured training session, 104 anaesthetists took part individually in a simulated can't intubate, can't oxygenate event using simulation and airway models to evaluate how well they could perform these front-of-neck access techniques. Main outcomes measures were: ability to correctly perform the technical steps; procedural time; and success rate...
January 19, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29347992/anatomical-relation-between-s1-sacroiliac-screws-entrance-points-and-superior-gluteal-artery
#3
Yong Zhao, Libo You, Wei Lian, Dexin Zou, Shengjie Dong, Tao Sun, Shudong Zhang, Dan Wang, Jingning Li, Wenliang Li, Yuchi Zhao
BACKGROUND: To conduct radiologic anatomical study on the relation between S1 sacroiliac screws' entry points and the route of the pelvic outer superior gluteal artery branches with the aim to provide the anatomical basis and technical reference for the avoidance of damage to the superior gluteal artery during the horizontal sacroiliac screw placement. METHODS: Superior gluteal artery CTA (CT angiography) vascular imaging of 74 healthy adults (37 women and 37 men) was done with 128-slice spiral CT (computed tomography)...
January 18, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29346414/reliability-of-plasma-polar-metabolite-concentrations-in-a-large-scale-cohort-study-using-capillary-electrophoresis-mass-spectrometry
#4
Sei Harada, Akiyoshi Hirayama, Queenie Chan, Ayako Kurihara, Kota Fukai, Miho Iida, Suzuka Kato, Daisuke Sugiyama, Kazuyo Kuwabara, Ayano Takeuchi, Miki Akiyama, Tomonori Okamura, Timothy M D Ebbels, Paul Elliott, Masaru Tomita, Asako Sato, Chizuru Suzuki, Masahiro Sugimoto, Tomoyoshi Soga, Toru Takebayashi
BACKGROUND: Cohort studies with metabolomics data are becoming more widespread, however, large-scale studies involving 10,000s of participants are still limited, especially in Asian populations. Therefore, we started the Tsuruoka Metabolomics Cohort Study enrolling 11,002 community-dwelling adults in Japan, and using capillary electrophoresis-mass spectrometry (CE-MS) and liquid chromatography-mass spectrometry. The CE-MS method is highly amenable to absolute quantification of polar metabolites, however, its reliability for large-scale measurement is unclear...
2018: PloS One
https://www.readbyqxmd.com/read/29344007/four-factor-prothrombin-complex-concentrate-improves-thrombin-generation-and-prothrombin-time-in-patients-with-bleeding-complications-related-to-rivaroxaban-a-single-center-pilot-trial
#5
Bettina Schenk, Stephanie Goerke, Ronny Beer, Raimund Helbok, Dietmar Fries, Mirjam Bachler
Background: Direct oral anticoagulants (DOACs) pose a great challenge for physicians in life-threatening bleeding events. The aim of this study was to test the efficacy of reversing the DOAC rivaroxaban using four-factor PCC (prothrombin complex concentrate), a non-specific reversing agent. Methods: Patients with life-threatening bleeding events during rivaroxaban treatment were included and administered 25 U kg-1 of PCC. Blood samples were collected immediately prior to as well as after PCC treatment at predefined time intervals...
2018: Thrombosis Journal
https://www.readbyqxmd.com/read/29343992/validation-of-bp-devices-qardioarm%C3%A2-in-the-general-population-and-omron-m6-comfort%C3%A2-in-type-ii-diabetic-patients-according-to-the-european-society-of-hypertension-international-protocol-esh-ip
#6
Mirna N Chahine, Jirar Topouchian, Parounak Zelveian, Zoya Hakobyan, Arevik Melkonyan, Alaa Azaki, Reem Diab, Aya Harb, Roland Asmar
Background: Following the European Society of Hypertension International Protocol (ESH-IP) Revision 2010, QardioArm® and Omron M6 Comfort IT® oscillometric devices were evaluated in the general population and in patients with type II diabetes, respectively, for self-blood pressure (BP) measurement. Methods: Both devices, QardioArm® and Omron M6 Comfort®, measure BP at the brachial level. The ESH-IP Revision 2010 includes a total number of 33 subjects. For each measure, the difference between observer and device BP values was calculated...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29330599/infraorbital-foramen-localization-in-orbitozygomatic-fractures-a-ct-study-with-intraoperative-finding
#7
Mohammad Waheed El-Anwar, Ahmed Hassan Sweed
OBJECTIVE: The aim of this study was to assess the infraorbital foramen (IOF) using CT in patients with Zygomaticomaxillary complex (ZMC) fractures (midface fracture). PATIENTS AND METHODS: This prospective study was carried out on 49 patients had ZMC fractures (98 sides) and 27 patients (54 sides) with craniomaxillofacial fractures rather than fractured ZMC as a control. Using CT, position of IOF was documented on 3D view in relation to inferior orbital rim, tooth root relation and finally with a novel imaginary line passing between anterior nasal spine and whitnall tubercle...
January 12, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29329756/phospholipid-composition-of-the-outer-membrane-of-escherichia-coli-influences-its-susceptibility-against-antimicrobial-peptide-apidaecin-1b
#8
Rico Schmidt, Ding Yonghong, Ralf Hoffmann
Proline-rich antimicrobial peptides (PrAMPs) kill bacteria in a multimodal mechanism by inhibiting the 70S ribosome (i.e., protein translation) as dominant lethal mechanism besides inhibition of several other proteins, such as chaperone DnaK. PrAMPs pass the outer membrane of Gram-negative bacteria, probably by a self-promoted uptake followed by a transporter-mediated uptake from the periplasm. Mutation of transporter protein SbmA is a well-studied resistance mechanism observed in vitro by resistance induction with PrAMPs...
November 21, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29325429/a-novel-method-for-re-positioning-suboptimally-preoperatively-placed-nephrostomy-tubes-for-pcnl-without-renal-re-puncture
#9
Yazeed Barghouthy, Vasileios Kourmpetis, Snir Dekalo, Yuval Bar-Yosef, Simon Conti, Alexander Greenstein, Mario Sofer
OBJECTIVE: Nephrostomy tubes (NT) inserted in emergency settings by interventional radiologists are frequently unsuitable for subsequent percutaneous nephrolithotomy (PCNL). We report a novel method of adjusting these NTs to be used as PCNL tracts and avoid renal re-puncture. PATIENTS AND METHODS: A retrospective search of 981 consecutive PCNLs performed in our institution between 2002-2017 identified all patients with preoperatively inserted NTs. The NTs unsuitable for PCNL were adjusted by a novel approach in which a 5-mm incision was made at the ideal puncture location (IPL) as indicated under fluoroscopic guidance...
January 12, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29320418/analysis-of-an-abe-scheme-with-verifiable-outsourced-decryption
#10
Yongjian Liao, Yichuan He, Fagen Li, Shaoquan Jiang, Shijie Zhou
Attribute-based encryption (ABE) is a popular cryptographic technology to protect the security of users' data in cloud computing. In order to reduce its decryption cost, outsourcing the decryption of ciphertexts is an available method, which enables users to outsource a large number of decryption operations to the cloud service provider. To guarantee the correctness of transformed ciphertexts computed by the cloud server via the outsourced decryption, it is necessary to check the correctness of the outsourced decryption to ensure security for the data of users...
January 10, 2018: Sensors
https://www.readbyqxmd.com/read/29314458/quality-of-omeprazole-purchased-via-the-internet-and-personally-imported-into-japan-comparison-with-products-sampled-in-other-asian-countries
#11
Mohammad Sofiqur Rahman, Naoko Yoshida, Sakura Sugiura, Hirohito Tsuboi, Tep Keila, Heng Bun Kiet, Theingi Zin, Tsuyoshi Tanimoto, Kazuko Kimura
OBJECTIVE: To evaluate the quality of omeprazole personally imported into Japan via the internet and to compare the quality of these samples with previously collected samples from two other Asian countries. METHODS: The samples were evaluated by observation, authenticity investigation, and pharmacopoeial quality analysis. Quality comparison of some selected samples was carried out by dissolution profiling, Raman spectroscopy, and principle component analysis (PCA)...
January 5, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29314457/orientation-control-of-molecularly-functionalized-surfaces-applied-to-the-simultaneous-alignment-and-sorting-of-carbon-nanotubes
#12
Serxho Selmani, Derek Schipper
Self-assembly has been relied upon to provide molecular alignment in many advanced technological applications. However, despite its effectiveness it is inherently limited in its capability for optimization. Despite the potential benefits, the seemingly fundamental strategy of external orientation control has yet to be realized. Here we demonstrate a scheme which allows for the control of the orientation of small molecules covalently bound to a surface. The method exploits an alignment relay technique, passing alignment information through a liquid crystal medium to small molecules, yielding control over surface functionalization events...
January 4, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29314418/cerebral-blood-volume-mapping-with-ferumoxytol-in-dynamic-susceptibility-contrast-perfusion-mri-comparison-to-standard-of-care
#13
Csanad G Varallyay, Eric Nesbit, Andrea Horvath, Peter Varallyay, Rongwei Fu, Seymur Gahramanov, Leslie L Muldoon, Xin Li, William D Rooney, Edward A Neuwelt
BACKGROUND: Cerebral blood volume (CBV) mapping with a dynamic susceptibility contrast (DSC) perfusion technique has become a clinical tool in diagnosing and follow-up of brain tumors. Ferumoxytol, a long-circulating iron oxide nanoparticle, has been tested for CBV mapping, but the optimal dose has not been established. PURPOSE: To compare ferumoxytol DSC of two different doses to standard of care gadoteridol by analyzing time-intensity curves and CBV maps in normal-appearing brain regions...
January 4, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29313261/enhancement-of-in-vivo-efficacy-and-oral-bioavailability-of-aripiprazole-with-solid-lipid-nanoparticles
#14
Silki, Vivek Ranjan Sinha
Aripiprazole (ARP), a second-generation or atypical antipsychotic, is poorly soluble and undergoes extensive hepatic metabolism and P-glycoprotein efflux which lead to reduced in vivo efficacy and increased dose-related side effects. To enhance in vivo efficacy and oral bioavailability of aripiprazole, aripiprazole-loaded solid lipid nanoparticles (SLNs) were developed using tristearin as solid lipid. Tween 80 and sodium taurocholate were used as surfactants to prepare SLNs using microemulsification method...
January 8, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29310249/calibration-transfer-of-a-raman-spectroscopic-quantification-method-for-the-assessment-of-liquid-detergent-compositions-from-at-line-laboratory-to-in-line-industrial-scale
#15
D Brouckaert, J-S Uyttersprot, W Broeckx, T De Beer
Calibration transfer or standardisation aims at creating a uniform spectral response on different spectroscopic instruments or under varying conditions, without requiring a full recalibration for each situation. In the current study, this strategy is applied to construct at-line multivariate calibration models and consequently employ them in-line in a continuous industrial production line, using the same spectrometer. Firstly, quantitative multivariate models are constructed at-line at laboratory scale for predicting the concentration of two main ingredients in hard surface cleaners...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29308546/fluid-mechanics-of-windkessel-effect
#16
C C Mei, J Zhang, H X Jing
We describe a mechanistic model of Windkessel phenomenon based on the linear dynamics of fluid-structure interactions. The phenomenon has its origin in an old-fashioned fire-fighting equipment where an air chamber serves to transform the intermittent influx from a pump to a more steady stream out of the hose. A similar mechanism exists in the cardiovascular system where blood injected intermittantly from the heart becomes rather smooth after passing through an elastic aorta. In existing haeodynamics literature, this mechanism is explained on the basis of electric circuit analogy with empirical impedances...
January 8, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29305200/ultrasound-for-intraoperative-confirmation-of-antegrade-ureteral-stent-placement-during-laparoscopic-pyeloplasty
#17
David B Bayne, Manint Usawachintachit, Thomas Chi
OBJECTIVE: To describe our ultrasound technique for confirming intraoperative, antegrade-placed ureteral stent position during laparoscopic pyeloplasty. BACKGROUND: Disadvantages of retrograde stent placement include the need to reposition the patient into and out of the lithotomy position. Antegrade stent placement can reduce procedure time but requires confirming appropriate distal placement into the bladder with cystoscopy, percutaneous drain placement, or instillation of methylthioninium chloride or indigo carmine...
January 2, 2018: Urology
https://www.readbyqxmd.com/read/29304180/the-effect-of-facility-characteristics-on-patient-safety-patient-experience-and-service-availability-for-procedures-in-non-hospital-affiliated-outpatient-settings-a-systematic-review
#18
Nancy F Berglas, Molly F Battistelli, Wanda K Nicholson, Mindy Sobota, Richard D Urman, Sarah C M Roberts
BACKGROUND: Over recent decades, numerous medical procedures have migrated out of hospitals and into freestanding ambulatory surgery centers (ASCs) and physician offices, with possible implications for patient outcomes. In response, states have passed regulations for office-based surgeries, private organizations have established standards for facility accreditation, and professional associations have developed clinical guidelines. While abortions have been performed in office setting for decades, states have also enacted laws requiring that facilities that perform abortions meet specific requirements...
2018: PloS One
https://www.readbyqxmd.com/read/29303149/assessment-and-management-of-dry-eye-disease
#19
R J Buckley
The topic of the 1984 Cambridge Ophthalmological Symposium was 'The Dry Eye'; it was chaired by my colleague and mentor Mr Peter Wright. In the 33 years that have passed since then we have learned a great deal more about this condition. This short paper sets out to review some of the more recent developments.Eye advance online publication, 5 January 2018; doi:10.1038/eye.2017.289.
January 5, 2018: Eye
https://www.readbyqxmd.com/read/29301001/the-gateway-from-near-into-remote-oceania-new-insights-from-genome-wide-data
#20
Irina Pugach, Ana T Duggan, D Andrew Merriwether, Françoise R Friedlaender, Jonathan S Friedlaender, Mark Stoneking
A widely accepted two-wave scenario of human settlement of Oceania involves the first out-of-Africa migration ca 50,000 ya, and one of the most geographically-widespread dispersals of people, known as the Austronesian expansion, which reached the Bismarck Archipelago by about 3,450 ya. While earlier genetic studies provided evidence for extensive sex-biased admixture between the incoming and the indigenous populations, some archaeological, linguistic and genetic evidence indicates a more complicated picture of settlement...
January 2, 2018: Molecular Biology and Evolution
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