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https://www.readbyqxmd.com/read/28335886/neoscope-a-randomised-phase-ii-study-of-induction-chemotherapy-followed-by-oxaliplatin-capecitabine-or-carboplatin-paclitaxel-based-pre-operative-chemoradiation-for-resectable-oesophageal-adenocarcinoma
#1
Somnath Mukherjee, Christopher Nicholas Hurt, Sarah Gwynne, David Sebag-Montefiore, Ganesh Radhakrishna, Simon Gollins, Maria Hawkins, Heike I Grabsch, Gareth Jones, Stephen Falk, Ricky Sharma, Andrew Bateman, Rajarshi Roy, Ruby Ray, Jo Canham, Gareth Griffiths, Tim Maughan, Tom Crosby
BACKGROUND: Oxaliplatin-capecitabine (OxCap) and carboplatin-paclitaxel (CarPac) based neo-adjuvant chemoradiotherapy (nCRT) have shown promising activity in localised, resectable oesophageal cancer. PATIENTS AND METHODS: A non-blinded, randomised (1:1 via a centralised computer system), 'pick a winner' phase II trial. Patients with resectable oesophageal adenocarcinoma ≥ cT3 and/or ≥ cN1 were randomised to OxCapRT (oxaliplatin 85 mg/m(2) day 1, 15, 29; capecitabine 625 mg/m(2) bd on days of radiotherapy) or CarPacRT (carboplatin AUC2; paclitaxel 50 mg/m(2) day 1, 8, 15, 22, 29)...
March 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28333590/mean-first-passage-memory-lifetimes-by-reducing-complex-synapses-to-simple-synapses
#2
Terry Elliott
Memory models that store new memories by forgetting old ones have memory lifetimes that are rather short and grow only logarithmically in the number of synapses. Attempts to overcome these deficits include "complex" models of synaptic plasticity in which synapses possess internal states governing the expression of synaptic plasticity. Integrate-and-express, filter-based models of synaptic plasticity propose that synapses act as low-pass filters, integrating plasticity induction signals before expressing synaptic plasticity...
March 23, 2017: Neural Computation
https://www.readbyqxmd.com/read/28332992/clinical-implementation-of-a-model-based-in%C3%A2-vivo-dose-verification-system-for-stereotactic-body-radiation-therapy-volumetric-modulated-arc-therapy-treatments-using-the-electronic-portal-imaging-device
#3
Peter M McCowan, Ganiyu Asuni, Eric Van Uytven, Timothy VanBeek, Boyd M C McCurdy, Shaun K Loewen, Naseer Ahmed, Bashir Bashir, James B Butler, Amitava Chowdhury, Arbind Dubey, Ahmet Leylek, Maged Nashed
PURPOSE: To report findings from an in vivo dosimetry program implemented for all stereotactic body radiation therapy patients over a 31-month period and discuss the value and challenges of utilizing in vivo electronic portal imaging device (EPID) dosimetry clinically. METHODS AND MATERIALS: From December 2013 to July 2016, 117 stereotactic body radiation therapy-volumetric modulated arc therapy patients (100 lung, 15 spine, and 2 liver) underwent 602 EPID-based in vivo dose verification events...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28332443/migration-assessment-and-the-threshold-of-toxicological-concern-applied-to-the-safe-design-of-an-acrylic-adhesive-for-food-contact-laminates
#4
Elena Canellas, Paula Vera, Cristina Nerín
Adhesives are widely used in food packaging. The suitability of an acrylic adhesive used on food packaging has been studied. Six potential migrants have been identified using GC-MS and UPLC-QTOF. Five compounds were intentionally added (2-butoxyethanol and 2,4,7,9-tetramethyl-5-decyne-4,7-diol (TMDD) and TMDD ethoxylates). Moreover, one of the compounds identified as 2-(12-(methacryloyloxy)dodecyl)malonic acid was a non-intenionally added substance (NIAS), that could be a methyl metacrylate derivative. This has demonstrated that the identification of compounds in food packaging is an essential step when the risk evaluation of the package is being studied...
March 23, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28330271/assessment-of-protein-silver-nanoparticles-toxicity-against-pathogenic-alternaria-solani
#5
Sobhy I I Abdel-Hafez, Nivien A Nafady, Ismail R Abdel-Rahim, Abeer M Shaltout, José-Antonio Daròs, Mohamed A Mohamed
Mycogenic synthesis of silver nanoparticles (AgNPs) was carried out in the present investigation using an aqueous extract of endophytic non-pathogenic Alternaria solani F10 (KT721914). The mycosynthesized AgNPs were characterized by means of spectroscopic and microscopic techniques. The surface plasmon resonance found at 430 nm confirmed the formation of stable AgNPs for several weeks at room temperature. Also, the results revealed the formation of spherical and monodispersed AgNPs with an average size of 14...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28326860/latvian-family-physicians-experience-diagnosing-depression-in-somatically-presenting-depression-patients-a-qualitative-study
#6
Maija S Leff, Jeļena Vrubļevska, Agita Lūse, Elmārs Rancāns
BACKGROUND: Depression continues to be under-diagnosed in primary care settings. One factor that influences physicians' likelihood of diagnosing depression is patients' presentation style. Patients who initially present with somatic symptoms are diagnosed at a lower rate and with greater delay than patients who present with psychosocial complaints. OBJECTIVES: To identify the barriers preventing depression diagnosis in somatically presenting patients in an Eastern European primary care setting...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/28319757/interaction-driver-bicyclist-on-rural-roads-effects-of-cross-sections-and-road-geometric-elements
#7
Francesco Bella, Manuel Silvestri
The interaction of motorists and bicyclists, particularly during passing maneuvers, is cited as one of the primary causes of bicyclist fatalities. This paper reports the results of a driving simulator study, which sought to analyze the effects that three cross-section configurations of a two-lane rural road and four geometric elements of the road have on driver behavior, during the interaction with a cyclist. A two-lane rural road, about 11km long, was designed and implemented in an advanced-interactive driving simulator...
March 17, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28318101/individual-volume-based-3d-gamma-indices-for-pretreatment-vmat-qa
#8
Jinling Yi, Ce Han, Xiaomin Zheng, Yongqiang Zhou, Zhenxiang Deng, Congying Xie, Xiance Jin, Fu Jin
Although gamma analysis is still a widely accepted quantitative tool to analyze and report patient-specific QA for intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT), the correlation between the 2D percentage gamma passing rate (%GP), and the clinical dosimetric difference for IMRT and VMAT has been questioned. The purpose of this study was to investigate the feasibility of individual volume-based 3D gamma indices for pretreatment VMAT QA. Percentage dosimetric errors (%DE) of dose-volume histogram metrics (includes target volumes and organ at risks) between the treatment planning system and QA-reconstructed dose distribution, %GPs for individual volume and global gamma indices, as well their correlations and sensitivities were investigated for one- and two-arc VMAT plans...
March 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28316653/large-scale-virtual-screening-on-public-cloud-resources-with-apache-spark
#9
Marco Capuccini, Laeeq Ahmed, Wesley Schaal, Erwin Laure, Ola Spjuth
BACKGROUND: Structure-based virtual screening is an in-silico method to screen a target receptor against a virtual molecular library. Applying docking-based screening to large molecular libraries can be computationally expensive, however it constitutes a trivially parallelizable task. Most of the available parallel implementations are based on message passing interface, relying on low failure rate hardware and fast network connection. Google's MapReduce revolutionized large-scale analysis, enabling the processing of massive datasets on commodity hardware and cloud resources, providing transparent scalability and fault tolerance at the software level...
2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/28315666/feasibility-and-safety-of-a-powered-exoskeleton-for-assisted-walking-for-persons-with-multiple-sclerosis-a-single-group-preliminary-study
#10
Allan J Kozlowski, Michelle Fabian, Dipan Lad, Andrew Delgado
OBJECTIVE: To examine the feasibility, safety, and secondary benefit potential of exoskeleton-assisted walking with one device for persons with multiple sclerosis (MS) DESIGN: Single-group longitudinal preliminary study with 8-week baseline, 8-week intervention, and 4-week follow-up. SETTING: Outpatient MS clinic at tertiary care hospital. PARTICIPANTS: The 13 participants were mostly female who ranged in age from 38-62 years and on Expanded Disability Status Scale scores from 5...
March 15, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28304284/scanning-gate-microscopy-of-magnetic-focusing-in-graphene-devices-quantum-vs-classical-simulation
#11
Marko D Petrović, Slaviša Milovanović, Francois Peeters
We compare classical versus quantum electron transport in recently investigated magnetic focusing devices [S. Bhandari et al., Nano Lett. 16, 1690 (2016)] exposed to the perturbing potential of a scanning gate microscope (SGM). Using the Landauer-Büttiker formalism for a multi-terminal device, we calculate resistance maps that are obtained as the SGM tip is scanned over the sample. There are three unique regimes in which the scanning tip can operate (focusing, repelling, and mixed regime) which are investigated...
March 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28302021/cytokines-induced-during-influenza-virus-infection
#12
Tatiana Betáková, Anna Kostrabova, Veronika Lachova, Lucia Turianova
Influenza A virus is one of the major human pathogens. The influenza infection can pass out without any subclinical symptoms or infestation can appear in upper respiratory tract as well as in lower respiratory tract where it can result in lethal outcome. Both innate and adaptive immune responses are activated shortly after infection providing protection against infection. Many activities of the cells of innate and adaptive immunity are coordinated by cytokines. However, inordinate or disbalanced immune response may result in overproduction of cytokines as well as chemokines what can lead to severe inflammation, including excessive recruitment of neutrophils and mononuclear cells at the site of infection...
March 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28301012/evaluation-of-eye-protection-filters-used-with-broad-spectrum-and-conventional-led-curing-lights
#13
Carlos José Soares, Monise de Paula Rodrigues, Andomar Bruno Fernandes Vilela, Erick René Cerda Rizo, Lorraine Braga Ferreira, Marcelo Giannini, Richard Bengt Price
The high irradiance and the different emission spectra from contemporary light curing units (LCU) may cause ocular damage. This study evaluated the ability of 15 eye protection filters: 2 glasses, 1 paddle design, and 12 dedicated filters to block out harmful light from a monowave (HP-3M ESPE) and a broad-spectrum (Valo, Ultradent) LED LCU. Using the anterior sensor in the MARC-Patient Simulator (BlueLight Analytics) the irradiance that was delivered through different eye protection filters was measured three times...
January 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28300388/the-assessment-and-characterization-of-the-built-in-internal-photometer-of-primary-diagnostic-monitors
#14
Andres E Ruuge, Usman A Mahmood, Yusuf E Erdi
The purpose of this work was to perform the initial evaluation of primary diagnostic monitor (PDM) characteristics following the implementation of New York City quality assurance (NYC QA) regulations on January 1, 2016, and compare the results of the QA measurements performed by an external photometer and the PDM manufacturer's built-in photometer. TG-18 and Society of Motion Picture and Television Engineers test patterns were used to evaluate monitor performance. Overall, 79 PDMs were included in the analysis...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28298665/application-of-micropore-filter-technology-exploring-the-blood-flow-path-in-arterial-line-filters-and-its-effect-on-bubble-trapping-functions
#15
Daniel P Herbst
Conventional arterial-line filters commonly use a large volume circular shaped housing, a wetted micropore screen, and a purge port to trap, separate, and remove gas bubbles from extracorporeal blood flow. Focusing on the bubble trapping function, this work attempts to explore how the filter housing shape and its resulting blood flow path affect the clinical application of arterial-line filters in terms of gross air handling. A video camera was used in a wet-lab setting to record observations made during gross air-bolus injections in three different radially designed filters using a 30-70% glycerol-saline mixture flowing at 4...
March 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28298482/movement-disorder-associated-with-foreign-body-ingestion
#16
Olugbenga Akingbola, Dinesh Singh, Uwe Blecker
We present a case of recurrent bouts of irritability with arching, head extension, and lethargy in a previously healthy 10-month-old girl admitted to the PICU for acute onset of a movement disorder. The patient's vital signs and physical examination were unremarkable but recurrent bouts of abnormal movements persisted for the first 10 hours of admission in the PICU. Possible diagnoses, such as meningitis, status epilepticus, space occupying lesions, and toxic ingestions, were ruled out because of negative cerebrospinal fluid analysis, normal EEG, and negative results of other ancillary tests...
March 15, 2017: Pediatrics
https://www.readbyqxmd.com/read/28297857/mean-field-message-passing-equations-in-the-hopfield-model-and-its-generalizations
#17
Marc Mézard
Motivated by recent progress in using restricted Boltzmann machines as preprocessing algorithms for deep neural network, we revisit the mean-field equations [belief-propagation and Thouless-Anderson Palmer (TAP) equations] in the best understood of such machines, namely the Hopfield model of neural networks, and we explicit how they can be used as iterative message-passing algorithms, providing a fast method to compute the local polarizations of neurons. In the "retrieval phase", where neurons polarize in the direction of one memorized pattern, we point out a major difference between the belief propagation and TAP equations: The set of belief propagation equations depends on the pattern which is retrieved, while one can use a unique set of TAP equations...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297428/a-dosimetric-comparison-of-copper-and-cerrobend-electron-inserts
#18
Benjamin D Rusk, Robert L Carver, John P Gibbons, Kenneth R Hogstrom
The purpose of this work was to evaluate differences in dose resulting from the use of copper aperture inserts compared to lead-alloy (Cerrobend) aperture inserts for electron beam therapy. Specifically, this study examines if copper aperture inserts can be used clinically with the same commissioning data measured using lead-alloy aperture inserts. The copper inserts were acquired from .decimal, Inc. and matching lead-alloy, Cerrobend inserts were constructed in-house for 32 combinations of nine square insert field sizes (2×2 to 20×20 cm2) and five applicator sizes (6×6 to 25×25 cm2)...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297355/mr-image-based-synthetic-ct-for-imrt-prostate-treatment-planning-and-cbct-image-guided-localization
#19
Shupeng Chen, Hong Quan, An Qin, Seonghwan Yee, Di Yan
The purpose of this study was to propose and evaluate a method of creating a synthetic CT (S-CT) from MRI simulation for dose calculation and daily CBCT localization. A pair of MR and CT images was obtained in the same day from each of 10 prostate patients. The pair of MR and CT images was preregistered using the deformable image registration (DIR). Using the corresponding displacement vector field (atlas-DVF), the CT image was deformed to the MR image to create an atlas MR-CT pair. Regions of interest (ROI) on the atlas MR-CT pair were delineated and used to create atlas-ROI masks...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297276/rounded-leaf-end-modeling-in-pinnacle-vmat-treatment-planning-for-fixed-jaw-linacs
#20
Lori A Young, Fei Yang, Ning Cao, Juergen Meyer
During volume-modulated arc therapies (VMAT), dosimetric errors are introduced by multiple open dynamic leaf gaps that are present in fixed diaphragm linear accelerators. The purpose of this work was to develop a methodology for adjusting the rounded leaf end modeling parameters to improve out-of-field dose agreement in SmartArc VMAT treatment plans delivered by fixed jaw linacs where leaf gap dose is not negligible. Leaf gap doses were measured for an Elekta beam modulator linac with 0.4 cm micro-multileaf collimators (MLC) using an A16 micro-ionization chamber, a MatriXX ion chamber detector array, and Kodak EDR2 film dosimetry in a solid water phantom...
November 2016: Journal of Applied Clinical Medical Physics
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