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https://www.readbyqxmd.com/read/28432980/discovery-of-potential-inhibitor-against-human-acetylcholinesterase-a-molecular-docking-and-molecular-dynamics-investigation
#1
Surya Pratap Singh, Dwijendra Gupta
Alzheimer's disease (AD) is a progressive neurodegenerative disease of central nervous system among elderly people. Human acetylcholinesterase (hAChE), an important enzyme in neuronal signaling, is responsible for the degradation of acetylcholine which in turn prevents the post synaptic signal transmissions. hAChE has been an attractive target of drug discovery for the search of therapeutics against AD. In the recent past hAChE has become hot target for the investigation of new potential therapeutics. We performed virtual screening of entire database against hAChE...
April 12, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28425057/quantifying-synergies-in-two-versus-one-situations-in-team-sports-an-example-from-rugby-union
#2
P Passos, J Milho, C Button
Collective behaviors in team sports result in players forming interpersonal synergies that contribute to performance goals. Because of the huge amount of variables that continuously constrain players' behavior during a game, the way that these synergies are formed remain unclear. Our aim was to quantify interpersonal synergies in the team sport of Rugby Union. For that purpose we used the Uncontrolled Manifold Hypothesis (UCM) to identify interpersonal synergies that are formed between ball carrier and support player in two-versus-one situations in Rugby Union...
April 19, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28423538/gene-regulatory-pattern-analysis-reveals-essential-role-of-core-transcriptional-factors-activation-in-triple-negative-breast-cancer
#3
Li Min, Cheng Zhang, Like Qu, Jialiang Huang, Lan Jiang, Jiafei Liu, Luca Pinello, Guo-Cheng Yuan, Chengchao Shou
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. Genome-scale molecular characteristics and regulatory mechanisms that distinguish TNBC from other subtypes remain incompletely characterized. RESULTS: By combining gene expression analysis and PANDA network, we defined three different TF regulatory patterns. A core TNBC-Specific TF Activation Driven Pattern (TNBCac) was specifically identified in TNBC by computational analysis...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28421894/how-learning-analytics-can-early-predict-under-achieving-students-in-a-blended-medical-education-course
#4
Mohammed Saqr, Uno Fors, Matti Tedre
AIM: Learning analytics (LA) is an emerging discipline that aims at analyzing students' online data in order to improve the learning process and optimize learning environments. It has yet un-explored potential in the field of medical education, which can be particularly helpful in the early prediction and identification of under-achieving students. The aim of this study was to identify quantitative markers collected from students' online activities that may correlate with students' final performance and to investigate the possibility of predicting the potential risk of a student failing or dropping out of a course...
April 19, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28412398/recent-update-on-nanoemulgel-as-topical-drug-delivery-system
#5
REVIEW
Hira Choudhury, Bapi Gorain, Manisha Pandey, Lipika Alok Chatterjee, Pinaki Sengupta, Arindam Das, Nagashekhara Molugulu, Prashant Kesharwani
Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising upshots for the lipophilic drugs over other formulations. This lipophilic nature of majority of the newer drugs developed in this modern era resulting in poor oral bioavailability, erratic absorption and pharmacokinetic variations. Therefore, this novel transdermal delivery system has been proved to be advantageous over other oral and/or topical drug delivery to avoid such disturbances. These nanoemulgels are basically oil-in-water nanoemulsions gelled with the use of some gelling agent in it...
April 12, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28409134/anatomical-variations-of-pronator-teres-muscle-predispositional-role-for-nerve-entrapment
#6
Edie Benedito Caetano, Luiz Ângelo Vieira, Fábio Antonio Anversa Sprovieri, Guilherme Camargo Petta, Maurício Tadeu Nakasone, Bárbara Lívia Correa Serafim
OBJECTIVE: To assess the anatomical variations of the pronator teres muscle (PTM) and its implication in the compression of the median nerve, which passes through the humeral and ulnar heads of the PTM. METHODS: For the present study, 100 upper limbs from human cadavers from the anatomy laboratory were dissected. Forty-six specimens were male and four, female, whose aged ranged from 28 to 77 years; 27 were white and 23, non-white. A pilot study consisting of six hands from three fresh cadaver dissections was conducted to familiarize the authors with the local anatomy; these were not included in the present study...
March 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28408279/evaluation-of-leachate-dissolved-organic-nitrogen-discharge-effect-on-wastewater-effluent-quality
#7
Stephanie C Bolyard, Debra R Reinhart
Nitrogen is limited more and more frequently in wastewater treatment plant (WWTP) effluents because of the concern of causing eutrophication in discharge waters. Twelve leachates from eight landfills in Florida and California were characterized for total nitrogen (TN) and dissolved organic nitrogen (DON). The average concentration of TN and DON in leachate was approximately 1146mg/L and 40mg/L, respectively. Solid-phase extraction was used to fractionate the DON based on hydrophobic (recalcitrant fraction) and hydrophilic (bioavailable fraction) chemical properties...
April 10, 2017: Waste Management
https://www.readbyqxmd.com/read/28407087/rp-hplc-separation-of-isomeric-withanolides-method-development-validation-and-application-to-in-situ-rat-permeability-determination
#8
Mohd Yaseen Malik, Isha Taneja, Kanumuri Siva Rama Raju, Jiaur Rahaman Gayen, Sheelendra Pratap Singh, Neelam S Sangwand, Muhammad Wahajuddin
Withanolides are the group of active chemical constituents of Withania somnifera (L.) Dunal. Withaferin A, withanolide A and withanone presents three of the biologically most active constituents of this herb. These steroidal lactones are isomers of each other and thus, pose significant difficulty in their separation. In present study, a simple, specific and reliable RP-HPLC method has been developed and validated for their separation and simultaneous quantification. Separation was carried out on Lichrocart Purospher STAR RP-18e column (250 × 4...
April 12, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28404553/airway-emergencies-presenting-to-the-paediatric-emergency-department-requiring-advanced-management-techniques
#9
Leopold Simma, Domenic Cincotta, Stefan Sabato, Elliot Long
BACKGROUND: Airway emergencies presenting to the emergency department (ED) are usually managed with conventional equipment and techniques. The patient group managed urgently in the operating room (OR) has not been described. AIMS: This study aims to describe a case series of children presenting to the ED with airway emergencies managed urgently in the OR, particularly the anaesthetic equipment and techniques used and airway findings. METHODS: A retrospective cohort study undertaken at The Royal Children's Hospital, Melbourne, Australia...
April 12, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28401080/comparison-of-the-frequency-of-y-short-tandem-repeats-markers-between-sadat-and-non-sadat-populations-in-isfahan-province-of-iran
#10
Reihaneh Seyedebrahimi, Ebrahim Esfandiari, Bahman Rashidi, Rasoul Salehi, Ali Gholami Dahghi, Shahriar Dabiri, Majid Kheirollahi
BACKGROUND: Y chromosome is one of the two sex chromosomes and is male specific. Due to limited genetic exchange, the main part of that is passed virtually unchanged from one generation to next generation. The short tandem repeats (STRs) are almost constant on chromosomes that make them as an appropriate factor for use in population genetic studies. In this study, we used the STRs of Y chromosome markers in Sadat families and comparison with other families was investigated. MATERIALS AND METHODS: In this study, sampling was done from fifty unrelated males of Sadat families and fifty unrelated males of non-Sadat families...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28399352/socioeconomic-characteristics-health-risk-factors-and-alcohol-consumption-among-the-homeless-in-north-eastern-part-of-poland
#11
Jerzy Romaszko, Robert Kuchta, Cezary Opalach, Anna Bertrand-Bucińska, Anna Maria Romaszko, Beata Giergielewicz-Januszko, Adam Buciński
BACKGROUND: Homelessness is a form of social pathology, which is for various reasons undesirable and as far as possible limited by efforts such as programmes that assist in transitioning out of homelessness. Because, as time passes, the homeless population undergoes both quantitative and qualitative changes, the process of developing these programmes requires up-to-date information on the extent and profile of this phenomenon that takes into account the characteristics of a given country...
March 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28391823/location-of-mammograms-roi-s-and-reduction-of-false-positive
#12
Luis Antonio Salazar-Licea, Jesús Carlos Pedraza-Ortega, Alberto Pastrana-Palma, Marco A Aceves-Fernandez
BACKGROUND AND OBJECTIVE: There are many work related with segmentation techniques, including nearest neighbor algorithm, fuzzy rules, morphological filters, image entropy, thresholding, machine learning, wavelet analysis, and so on. Such methods carry out the segmentation, but take a lot of processing time by modifying the content of the image or showing discern problems in homogeneous areas, and the segmentation technique is designed to work efficiently only with the techniques used...
May 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28391082/estradiol-loaded-plga-nanoparticles-for-improving-low-bone-mineral-density-of-cancellous-bone-caused-by-osteoporosis-application-of-enhanced-charged-nanoparticles-with-iontophoresis
#13
Issei Takeuchi, Shiori Kobayashi, Yukari Hida, Kimiko Makino
Postmenopausal osteoporosis among older women, which occurs by an ovarian hormone deficiency, is one of the major public health problems. 17 β-estradiol (E2) is used to prevent and treat this disease as a drug of hormone replacement therapy. In oral administration, E2 is significantly affected by first-pass hepatic metabolism, and high dose administration must be needed to obtain drug efficacy. Therefore, alternative administration route is needed, and we have focused on the transdermal drug delivery system...
March 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28388869/annals-express-stimulating-tsh-receptor-autoantibodies-immunoassay-analytical-evaluation-and-clinical-performance-in-graves-disease
#14
Chiara Autilio, Renato Morelli, Pietro Locantore, Alfredo Pontecorvi, Cecilia Zuppi, Cinzia Carrozza
BACKGROUND: Thyroid stimulating hormone (TSH) receptor (TSHR) autoantibodies (TRAbs) are a heterogeneous group of antibodies (Abs) with different functionality. Among all TRAbs only the stimulating one (S-TRAbs) are considered the pathogenetic marker of Graves' Disease (GD). To date, the methods available for TRAbs testing are based on immunoassays (IMAs) which detect total serum TRAbs or bioassays which are not suitable in clinical practice, even though they discern Abs functionality...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28385174/take-home-training-in-laparoscopy
#15
Ebbe Thinggaard
When laparoscopy was first introduced, skills were primarily taught using the apprenticeship model. A limitation of this method when compared to open surgery, was that it requires more time to practise and more frequent learning opportunities in clinical practice. The unique set of skills required in laparoscopy highlighted the need for new training methods that reduce the need for supervision and do not put the patient at risk. Simulation training was developed to meet this need. The overall purpose of this thesis was to explore simulation-based laparoscopic training at home...
April 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28379057/metoclopramide-nasal-spray-in-vitro-evaluation-and-in-vivo-pharmacokinetic-studies-in-dogs
#16
Ying Li, Xianpeng Fan, Wanqing Li, Peng Yang, Hui Zhang, Daoquan Tang, Xiaoxin Yin, Jianxu Sun, Aiping Zheng
Metoclopramide (MCP) can effectively alleviate motion sickness-caused nausea and vomiting. Nasal administration offers the greatest patient compliance. It is suitable for self-administration and offers rapid and complete absorption, no first-pass effects, and high bioavailability. In present study, a MCP nasal spray was prepared and evaluated in vitro and in vivo. Nasal cilia toxicity of Bufo toads was used to screen the preservative types and concentrations. Rabbit nasal mucosa was used to evaluate the mucosa permeability of different MCP nasal sprays with different penetration enhancers and preservative...
April 5, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28378675/student-life-student-to-newly-qualified-nurse-make-a-checklist
#17
Jessica Ross
It is natural to feel nervous and apprehensive on your first day in uniform, but hopefully you will also feel excited. Your first day is a celebration of all the hard-won achievements throughout your training, so here are a few tips to help you make the most of it: » Organise a ward induction beforehand, or have a look around. Knowing where you are going and what your workplace looks like can help quell your nerves. » Running around trying to find a pair of scrubs to wear during handover is not ideal, so see if you can get your uniform in advance...
April 5, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28377644/finite-element-analysis-of-sagittal-balance-in-different-morphotype-forces-and-resulting-strain-in-pelvis-and-spine
#18
REVIEW
Vincenzo Filardi, Portaro Simona, Giorgio Cacciola, Salvatore Bertino, Luigi Soliera, Andrea Barbanera, Alessandro Pisani, Demetrio Milardi, Bramanti Alessia
In humans, vertical posture acquisition caused several changes in bones and muscles which can be assumed as verticalization. Pelvis, femur, and vertebral column gain an extension position which decreases muscular work by paravertebral muscles in the latter. It's widely known that six different morphological categories exist; each category differs from the others by pelvic parameters and vertebral column curvatures. Both values depend on the Pelvic Incidence, calculated as the angle between the axes passing through the rotation centre of the two femur heads and the vertical axis passing through the superior plate of the sacrum...
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28377153/clinical-performance-of-cardiac-troponin-i-a-comparison-between-the-poct-aqt90-flex-and-the-dimension-vista-analyzer-in-an-emergency-setting
#19
Monica Maria Mion, Giada Bragato, Alessandra Casarotti, Chiara Cosma, Stefania Vigolo, Gianna Vettore, Franco Tosato, Martina Zaninotto, Mario Plebani
BACKGROUND: Cardiac troponin [cTn (I or T)] is the preferred biomarker for the diagnosis of myocardial infarction (MI). AIM: We studied the analytical performance of the POCT AQT90 FLEX cTnI assay and its diagnostic accuracy, in comparison to the Dimension Vista cTnI method, in patients presenting to the Emergency Department (ED) with suspect of acute coronary syndrome (ACS). METHODS: 786 consecutive patients were enrolled. cTnI was measured at admission to the ED and about 3 and 6 hours later...
April 1, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28375281/collimation-testing-using-deflectometry-in-conjunction-with-windowed-fourier-transform-analysis
#20
Jitendra Dhanotia, Vimal Bhatia, Shashi Prakash
In this paper, we demonstrate a simple automated procedure for the detection of collimation of an optical beam by incorporating the windowed Fourier fringe analysis technique into a deflectometric setup. The experimental arrangement consists of a deflectometry-based system in which light from a laser is expanded and passed through a collimating lens. The transmitted light illuminates a coarse sinusoidal grating. The grating image is directly captured through a charge-coupled device. Typical image patterns corresponding to "in-focus," "at-focus," and "out-of-focus" positions of an optical beam are recorded...
March 10, 2017: Applied Optics
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