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https://www.readbyqxmd.com/read/28750312/synthesis-of-2-imino-and-2-hydrazono-thiazolo-4-5-d-pyrimidines-as-corticotropin-releasing-factor-crf-antagonists
#1
Mohamed Teleb, Bhimanna Kuppast, Katerina Spyridaki, George Liapakis, Hesham Fahmy
Corticotropin-releasing factor (CRF) is an important neuropeptide hormone which controls the body's overall response to stress. It plays a crucial role in regulating the behavioral, cardiovascular, immune and gastrointestinal systems. Over-activation of the CRF system has been implicated in many disorders including anxiety, depression, drug addiction, hypertension, Irritable Bowel Syndrome (IBS), peptic ulcers, inflammation and others. Thus, binding of CRF to its receptors is an attractive target to develop new medications which aim at treating ailments associated with chronic stress...
July 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28750179/effects-of-propofol-on-conditioned-place-preference-in-male-rats-involvement-of-nitrergic-system
#2
Andleeb Shahzadi, Tuğçe Uskur, A Gökhan Akkan, Burcu Çevreli, Tayfun Uzbay
BACKGROUND: Drug-induced conditioned place preference (CPP) is linked to the addictive properties of the drug used. The number of studies that have investigated the effects of propofol on CPP is limited. Research findings suggest that nitric oxide (NO) might play an important role in substance use disorders. OBJECTIVES: The present study sought to investigate the role of the nitrergic system on the rewarding effects of propofol by using the CPP protocol in rats...
July 27, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28749641/factors-affecting-mental-patients%C3%A2-behaviors-and-attitudes-regarding-smoking
#3
Michael Kourakos, Maria Saridi, Theodora Kafkia, Maria Rekleiti, Kyriakos Souliotis, Hero Brokalaki, Evmorfia Koukia
Background: Patients with mental health problems are in high risk to develop addiction, since smoking incidence is three times higher than that of the general population. The aim of the study was to investigate the factors affecting mental health patients’ smoking habits. Methods: The sample of study were 356 patients out of 403 initially approached, with 142 hospitalized in hospital facilities and 214 in community settings. The «Smoking in psychiatric hospitals” and General Health Questionnaire (GHQ-28) questionnaires were used...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749524/academic-outcomes-and-cognitive-performance-in-problematic-internet-users
#4
María Marín Vila, José Luis Carballo Crespo, Ainhoa Coloma Carmona
Only few studies have examined the relationship between problematic Internet use (PIU) and cognitive and academic performance in adolescents. The aim of this study was to analyze the differences in academic and cognitive performance (perception, attention, memory, verbal fluency and abstract reasoning) between adolescents with and without PIU. A total of 575 students from different high schools of the region of Alicante participated. Students were divided into two groups: adolescents with and without PIU (PIU and NPIU, respectively)...
July 13, 2017: Adicciones
https://www.readbyqxmd.com/read/28749523/questionnaire-of-core-beliefs-related-to-drug-use-and-craving-for-assessment-of-relapse-risk
#5
José Miguel Martínez-González, Raquel Vilar López, Oscar Lozano-Rojas, Antonio Verdejo-García
This study was aimed at designing a questionnaire for the assessment of addiction-related core beliefs and craving. The sample comprised 215 patients (85.8% males and 14.2% females) in treatment for dependence to alcohol (40%), cocaine (36.3%) and cannabis (23.7%). Descriptive statistics were used to characterize the sample. Variance, regression and factorial analyses were conducted to study the questionnaire structure and its relation with variables such as abstinence and craving. Items about drug-related beliefs yielded a four-factor structure: what patient think that they could not do without drug use, lack of withdrawal, conditions required to use drugs again, and use of drugs as the only way to feel good...
July 12, 2017: Adicciones
https://www.readbyqxmd.com/read/28749122/tobacco-use-and-effects-of-professional-advice-on-smoking-cessation-among-youth-in-india
#6
Siddardha G Chandrupatla, Mary Tavares, Zuhair S Natto
Objective: Healthcare professionals and addiction programs play important roles in tobacco use prevention and cessation activities. In this study, we analyzed the prevalence of tobacco use and the impact of smoking cessation advice through programs/professionals among a nationally representative sample of youth in India. Methods: The data were obtained from the Global Youth Tobacco Survey (GYTS) 2009 dataset from a nationally representative school based survey of 8th to 10th grade students in India (n=14,543)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28748984/deaths-from-acute-drug-reactions-in-galician-spain-prisons-2001-2010
#7
D Miguel-Arias, C Pereiro-Gómez, A M Bermejo-Barrera, C Vázquez-Ventoso, T Rodríguez-Barca
INTRODUCTION AND OBJECTIVES: drug use is associated with multiple complications with an increase in morbidity, with death by acute drugs reactions (ADR) being the most serious. A large percentage of the prison population has problems associated with drug additions, and substance abuse is also a common internal problem of penal institutions, despite their control measures. The goal of this study is to analyse the prevalence of ADR in penitentiaries, deceased sociodemographic characteristics as well as the circumstances in which they are produced...
December 2017: Revista Española de Sanidad Penitenciaria
https://www.readbyqxmd.com/read/28748788/reward-mechanisms-across-aggressive-and-addictive-forms-of-externalizing-psychopathology
#8
Noah C Venables
No abstract text is available yet for this article.
August 15, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28747877/combining-multiple-resting-state-fmri-features-during-classification-optimized-frameworks-and-their-application-to-nicotine-addiction
#9
Xiaoyu Ding, Yihong Yang, Elliot A Stein, Thomas J Ross
Machine learning techniques have been applied to resting-state fMRI data to predict neurological or neuropsychiatric disease states. Existing studies have used either a single type of resting-state feature or a few feature types (<4) in the prediction model. However, resting-state data can be processed in many different ways, yielding different feature types containing complementary and/or novel information, leaving uncertain the most informative features to provide to the classifier. In this study, multiple resting-state features were calculated from two main analytical categories: local measures and network measures...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28747817/conducting-systematic-outcome-assessment-in-private-addictions-treatment-settings
#10
Gerard J Connors, Stephen A Maisto, Clare E Campbell, Brenda To, David Sack
Systematic outcome assessment is central to ascertaining the impact of treatment services and to informing future treatment initiatives. This project was designed to be conducted within the clinical operations of 4 private addictions treatment centers. A structured interview was used to assess patients' alcohol and other drug use and related variables (on treatment entry and at 1, 3, and 6 months following treatment discharge). The primary outcomes were percentage of days abstinent (PDA) from alcohol and drugs, PDA from alcohol, and PDA from other drugs...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/28747521/a-novel-18-f-labeled-kappa-opioid-receptor-antagonist-as-pet-radiotracer-synthesis-and-in-vivo-evaluation-of-18-f-ly2459989-in-non-human-primates
#11
Songye Li, Zhengxin Cai, Ming-Qiang Zheng, Daniel Holden, Mika Naganawa, Shu-Fei Lin, Jim Ropchan, David Labaree, Michael Kapinos, Teresa Lara-Jaime, Antonio Navarro, Yiyun Huang
The kappa opioid receptor (KOR) is implicated in depression, addictions, and other central nervous system (CNS) disorders and thus an important target for drug development. We have previously developed a number of (11)C-labeled PET radiotracers for KOR imaging in humans. Here we report the synthesis and evaluation of (18)F-LY2459989 as the first (18)F-labeled KOR antagonist radiotracer in non-human primates and its comparison with (11)C-LY2459989. Methods: The novel radioligand (18)F-LY2459989 was synthesized by (18)F-displacement of a nitro group or an iodonium ylide...
July 26, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28747183/harm-reduction-in-name-but-not-substance-a-comparative-analysis-of-current-canadian-provincial-and-territorial-policy-frameworks
#12
Elaine Hyshka, Jalene Anderson-Baron, Kamagaju Karekezi, Lynne Belle-Isle, Richard Elliott, Bernie Pauly, Carol Strike, Mark Asbridge, Colleen Dell, Keely McBride, Andrew Hathaway, T Cameron Wild
BACKGROUND: In Canada, funding, administration, and delivery of health services-including those targeting people who use drugs-are primarily the responsibility of the provinces and territories. Access to harm reduction services varies across jurisdictions, possibly reflecting differences in provincial and territorial policy commitments. We examined the quality of current provincial and territorial harm reduction policies in Canada, relative to how well official documents reflect internationally recognized principles and attributes of a harm reduction approach...
July 26, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28747086/menthol-enhances-nicotine-induced-locomotor-sensitization-and-in-vivo-functional-connectivity-in-adolescence
#13
Matthew F Thompson, Guillaume L Poirier, Martha I Dávila-García, Wei Huang, Kelly Tam, Maxwell Robidoux, Michelle L Dubuke, Scott A Shaffer, Luis Colon-Perez, Marcelo Febo, Joseph R DiFranza, Jean A King
Mentholated cigarettes capture a quarter of the US market, and are disproportionately smoked by adolescents. Menthol allosterically modulates nicotinic acetylcholine receptor function, but its effects on the brain and nicotine addiction are unclear. To determine if menthol is psychoactive, we assessed locomotor sensitization and brain functional connectivity. Adolescent male Sprague Dawley rats were administered nicotine (0.4 mg/kg) daily with or without menthol (0.05 mg/kg or 5.38 mg/kg) for nine days. Following each injection, distance traveled in an open field was recorded...
July 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28746733/mothers-with-substance-addictions-show-reduced-reward-responses-when-viewing-their-own-infant-s-face
#14
Sohye Kim, Udita Iyengar, Linda C Mayes, Marc N Potenza, Helena J V Rutherford, Lane Strathearn
Maternal addiction constitutes a major public health problem affecting children, with high rates of abuse, neglect, and foster care placement. However, little is known about the ways in which substance addiction alters brain function related to maternal behavior. Prior studies have shown that infant face cues activate similar dopamine-associated brain reward regions to substances of abuse. Here, we report on a functional MRI study documenting that mothers with addictions demonstrate reduced activation of reward regions when shown reward-related cues of their own infants...
July 26, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28746146/isolated-native-tricuspid-valve-endocarditis-due-to-group-a-%C3%AE-hemolytic-streptococcus-without-drug-addiction
#15
Roberto Spoladore, Eustachio Agricola, Rossella D'Amato, Alessandro Durante, Gabriele Fragasso, Alberto Margonato
No abstract text is available yet for this article.
September 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28745916/experiences-and-perceived-social-support-among-iranian-men-on-methadone-maintenance-therapy-a-qualitative-study
#16
Nader Aghakhani, Violeta Lopez, Michelle Cleary
The use of drugs predominantly among Iranian men leads to health and social problems. Iran has established methadone maintenance therapy centres but there is limited research exploring the experiences of men who make use of this therapy. The aim of this qualitative study was to explore the experiences of men on methadone maintenance therapy in Urmia, Iran. Sixteen opioid-dependent males on methadone syrup substitution therapy were interviewed. Transcribed data were subjected to thematic analysis. Three themes emerged from the data: (1) the role of family in drug addiction; (2) the role of environment in drug addiction; and (3) the support needed to overcome drug addiction...
July 26, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28745668/-an-interim-analysis-of-the-results-of-treatment-program-implementation-with-the-use-of-injectable-extended-release-naltrexone-for-opioid-addicted-patients
#17
T V Agibalova, O V Nedobylskiy, K N Poplevchenkov, I I Sirotko, A V Shcherban, S A Tsarev
AIM: To analyze outcomes of treatment in the 'Point of soberness' program for opioid addicted patients (2015-2016 гг.). MATERIAL AND METHODS: The results of treatment of 83 opioid addicted patients were analyzed. Seventy-four (89.16%) patients received treatment course of injections of extended-release naltrexone (from 4 to 6 injections), maintaining their participation in the outpatient medical rehabilitation program. Thirty-six (43.37%) patients completed a full course of injections of extended-release naltrexone...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28745447/commentary-perspectives-on-alcohol-related-gene-and-environment-interplay-in-diverse-populations
#18
Marcia S Scott
BACKGROUND AND OBJECTIVES: Racial/ethnic groups comprise more than 20% of the U.S. population, but many experience disproportionately high risk for alcohol misuse, often resulting in higher rates of alcohol-associated consequences. Completion of mapping the human genome has launched rapidly evolving research methods aimed at improved understanding of genetic contribution to disease. Despite decades of research on the influence of genetic and environmental risks on alcohol use disorders and outcomes, few studies have included racial/ethnic subpopulations in sufficient numbers to allow for proper statistical analysis...
August 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28745446/conclusion-special-issue-on-genetic-and-alcohol-use-disorder-research-with-diverse-racial-ethnic-groups-key-findings-and-potential-next-steps
#19
Karen G Chartier, Michie N Hesselbrock, Victor M Hesselbrock
BACKGROUND AND OBJECTIVES: This special issue brings together papers focusing on a wide range of topics relevant to the research and understanding of the role of race/ethnicity and genetic variation for the susceptibility of developing an alcohol use disorder (AUD). METHODS: The key findings from the issue's 10 articles are reviewed and organized here around three topics: I: addictive behaviors and potential environmental influences; II: a focus on four racial/ethnic groups; and III: special methodologies...
August 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28745266/adolescents-from-upper-middle-class-communities-substance-misuse-and-addiction-across-early-adulthood-corrigendum
#20
Suniya S Luthar, Phillip J Small, Lucia Ciciolla
No abstract text is available yet for this article.
July 26, 2017: Development and Psychopathology
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