Daryn E Erickson, Kyle M Simmons, Zachary A Barrand, Chase L Ridenour, Paige B Hawkinson, Lacey Lemke, Shayne P Sellner, Breezy N Brock, Alexis N Rivas, Krystal Sheridan, Darrin Lemmer, Hayley D Yaglom, W Tanner Porter, Monique Belanger, Rachel M Torrey, Aidan James R Stills, Kiley McCormack, Matt Black, Wydale Holmes, Drew Rostain, Jeremy Mikus, Kimberly Sotelo, Emmen Haq, Reshma Neupane, Joli Weiss, Jasmine Johnson, Clancey Collins, Sarah Avalle, Chelsi White, Brandon J Howard, Sara A Maltinsky, Ryann N Whealy, Nathaniel B Gordon, Jason W Sahl, Talima Pearson, Viacheslav Y Fofanov, Tara Furstenau, Elizabeth M Driebe, J Gregory Caporaso, Jarrett Barber, Joel Terriquez, David M Engelthaler, Crystal M Hepp
BACKGROUND: Most seasonally circulating enteroviruses result in asymptomatic or mildly symptomatic infections. In rare cases, however, infection with some subtypes can result in paralysis or death. Of the 300 subtypes known, only poliovirus is reportable, limiting our understanding of the distribution of other enteroviruses that can cause clinical disease. OBJECTIVE: The overarching objectives of this study were to: 1) describe the distribution of enteroviruses in Arizona during the late summer and fall of 2022, the time of year when they are thought to be most abundant, and 2) demonstrate the utility of viral pan-assay approaches for semi-agnostic discovery that can be followed up by more targeted assays and phylogenomics...
March 20, 2024: medRxiv