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https://www.readbyqxmd.com/read/29161778/highly-efficient-destruction-of-squamous-carcinoma-cells-of-the-head-and-neck-by-photochemical-internalization-of-ranpirnase
#1
Nora Liebers, Tim Holland-Letz, Mona Welschof, Anders Høgset, Dirk Jäger, Michaela A E Arndt, Jürgen Krauss
Introduction: Photochemical Internalization is a novel drug delivery technology for cancer treatment based on the principle of Photodynamic Treatment. Using a photosensitizer that locates in endocytic vesicles membranes of tumor cells, Photochemical internalization enables cytosolic release of endocytosed antitumor agents in a site-specific manner. The purpose of the present in-vitro study was to explore whether Photochemical Internalization is able to enhance the efficacy of Ranpirnase, a cytotoxic amphibian ribonuclease, for eradication of squamous cell carcinoma of the head and neck...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29160910/epithelial-disruptions-but-not-immune-cell-invasion-induced-secretory-dysfunction-following-innate-immune-activation-in-a-novel-model-of-acute-salivary-gland-injury
#2
Abeer Shaalan, Guy Carpenter, Gordon Proctor
BACKGROUND: Salivary gland (SG) injurious agents are all translated into loss of salivation (xerostomia). An association has been established between activation of innate immunity and salivary gland injury and dysfunction. However, it remains unclear how the secretory epithelia respond by halting saliva production. METHODS: C57BL/6 submandibular glands (SMGs) were acutely challenged using a single dose of the innate immune stimulant: polyinosinic-polycytidylic acid (poly (I:C))...
November 21, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29159721/design-synthesis-in-silico-and-in-vitro-antimicrobial-screenings-of-novel-1-2-4-triazoles-carrying-1-2-3-triazole-scaffold-with-lipophilic-side-chain-tether
#3
Mohamed Reda Aouad, Mariem Mohammed Mayaba, Arshi Naqvi, Sanaa K Bardaweel, Fawzia Faleh Al-Blewi, Mouslim Messali, Nadjet Rezki
BACKGROUND: 1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry. RESULTS: This study describes a green, efficient and quick solvent free click synthesis of new 1,2,3-triazole-4,5-diesters carrying a lipophilic side chain via 1,3-dipolar cycloaddition of diethylacetylene dicarboxylate with different surfactant azides. Further structural modifications of the resulting 1,2,3-triazole diesters to their corresponding 1,2,4-triazole-3-thiones via multi-step synthesis has been also investigated...
November 21, 2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/29159704/neuroimmune-regulation-of-jc-virus-by-intracellular-and-extracellular-agnoprotein
#4
Michael Craigie, Stephanie Cicalese, Ilker Kudret Sariyer
JC virus (JCV) is a human polyomavirus and the etiologic agent of the demyelinating disease progressive multifocal leukoencephalopathy (PML). PML is observed in patients with underlying immunocompromising conditions, suggesting that neuro-immune interactions between peripheral immune cells and neuro-glia play an important role in controlling viral reactivation in the brain. There is little known about the immunobiology of JCV reactivation in glial cells and the role of immune, glial, and viral players in this regulation...
November 20, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29159596/human-monoclonal-antibodies-as-candidate-therapeutics-against-emerging-viruses
#5
REVIEW
Yujia Jin, Cheng Lei, Dan Hu, Dimiter S Dimitrov, Tianlei Ying
The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation...
November 20, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29159502/antifungal-activity-of-myrtus-communis-against-malassezia-sp-isolated-from-the-skin-of-patients-with-pityriasis-versicolor
#6
Aleksandra Barac, Matthew Donadu, Donatella Usai, Vesna Tomic Spiric, Vittorio Mazzarello, Stefania Zanetti, Ema Nikolic, Goran Stevanovic, Natasa Popovic, Salvatore Rubino
The increasing incidence of fungal infections and antifungal resistance has prompted the search for novel antifungal drugs and alternative agents. We explored the antifungal activity of Myrtus communis essential oil (EO) against Malassezia sp. isolated from the skin of patients with pityriasis versicolor. These broad-spectrum antimicrobial activities of M. communis EO and its potent inhibiting activity on Malassezia growth deserve further research with aim to considerate this EO as candidate for topical use in treatment of skin diseases...
November 20, 2017: Infection
https://www.readbyqxmd.com/read/29159425/novel-biosynthetic-pathway-for-sulfur-amino-acids-in-cryptococcus-neoformans
#7
Akio Toh-E, Misako Ohkusu, Kiminori Shimizu, Naruhiko Ishiwada, Akira Watanabe, Katsuhiko Kamei
We elucidated a unique feature of sulfur metabolism in Cryptococcus neoformans. C. neoformans produces cysteine solely by the O-acetylserine pathway that consists of serine-O-acetyl transferase and cysteine synthase. We designated the gene encoding the former enzyme CYS2 (locus tag CNE02740) and the latter enzyme CYS1 (locus tag CNL05880). The cys1Δmutant strain was found to be avirulent in a murine infection model. Methionine practically does not support growth of the cys1Δ strain, and cysteine does not serve as a methionine source, indicating that the transsulfuration pathway does not contribute to sulfur amino acid synthesis in C...
November 20, 2017: Current Genetics
https://www.readbyqxmd.com/read/29159359/highly-selective-and-sensitive-chromogenic-detection-of-nerve-agents-sarin-tabun-and-vx-a-multianalyte-detection-approach
#8
Vinod Kumar, G Raviraju, Hemlata Rana, Vepa Kameswara Rao, Arvind K Gupta
A novel strategy using ferrocenyl dye (1) was developed for highly selective chromogenic detection of all nerve agents. The protocol was first established with nerve agent mimics (DFP, DCNP, and malaoxon) and then implemented on real agents, i.e. sarin, tabun and VX. The developed chemosensor showed no interferences from the most probable interferents such as acetyl chloride, sulfur mustard, oxygen mustard and DMMP. Real-time visual detection with a lower limit of detection (below LD50) made the present protocol highly appealing and versatile...
November 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29159187/the-role-of-costimulation-blockade-in-solid-organ-and-islet-xenotransplantation
#9
REVIEW
Kannan P Samy, James R Butler, Ping Li, David K C Cooper, Burcin Ekser
Pig-to-human xenotransplantation offers a potential bridge to the growing disparity between patients with end-stage organ failure and graft availability. Early studies attempting to overcome cross-species barriers demonstrated robust humoral immune responses to discordant xenoantigens. Recent advances have led to highly efficient and targeted genomic editing, drastically altering the playing field towards rapid production of less immunogenic porcine tissues and even the discussion of human xenotransplantation trials...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29158872/neuroprotective-and-cognitive-enhancing-effects-of-microencapsulation-of-mulberry-fruit-extract-in-animal-model-of-menopausal-women-with-metabolic-syndrome
#10
Supannika Kawvised, Jintanaporn Wattanathorn, Wipawee Thukham-Mee
Currently, the neuroprotectant and memory-enhancing agent for menopausal women with metabolic syndrome is required. Based on the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation method, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory impairment in an animal model of menopause with metabolic syndrome. To test this hypothesis, MME at doses of 10, 50, and 250 mg/kg was given to female Wistar rats which were induced experimental menopause with metabolic syndrome by bilateral ovariectomy (OVX) and fed with high-carbohydrate high-fat (HCHF) diet for 8 weeks...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29158836/a-laser-activated-biocompatible-theranostic-nanoagent-for-targeted-multimodal-imaging-and-photothermal-therapy
#11
Liming Deng, Xiaojun Cai, Danli Sheng, Yang Yang, Eric M Strohm, Zhigang Wang, Haitao Ran, Dong Wang, Yuanyi Zheng, Pan Li, Tingting Shang, Yi Ling, Fengjuan Wang, Yang Sun
Multifunctional nanoparticles have been reported for cancer detection and treatment currently. However, the accurate diagnosis and efficient treatment for tumors are still not satisfied. Here we report on the development of targeted phase change multimodal polymeric nanoparticles for the imaging and treatment of HER2-positive breast cancer. METHODS: We evaluated the multimodal imaging capabilities of the prepared nanoparticles in vitro using agar-based phantoms. The targeting performance and cytotoxicity of the nanoparticles were examined in cell culture using SKBR3 (over-expressing HER2) and MDA-MB-231 (HER2 negative) cells...
2017: Theranostics
https://www.readbyqxmd.com/read/29158821/ultra-small-ph-responsive-nd-doped-nadyf4-nanoagents-for-enhanced-cancer-theranostic-by-in-situ-aggregation
#12
Yuxin Liu, Huimin Fan, Quanwei Guo, Anqi Jiang, Xiaoxia Du, Jing Zhou
To achieve accurate tumor location and highly efficient cancer therapy effect, the properties of cancer theranostic agents should be optimized and enhanced. In this work, ultra-small Nd doped NaDyF4 were firstly reported as novel contrast agents for near-infrared second window downconversion luminescence (NIR II DCL) and magnetic resonance imaging. Based on the optimization strategy, gallic acid-Fe(III) complex modified NaDyF4:10%Nd (NaDyF4:10%Nd-GA-Fe) was selected as the optimal agent with high transversal relaxivity, strong NIR II DCL, high photothermal conversion efficiency, and low toxicity...
2017: Theranostics
https://www.readbyqxmd.com/read/29158817/extracellular-vesicles-in-cardiovascular-theranostics
#13
REVIEW
Yihua Bei, Saumya Das, Rodosthenis S Rodosthenous, Paul Holvoet, Maarten Vanhaverbeke, Marta Chagas Monteiro, Valter Vinicius Silva Monteiro, Jana Radosinska, Monika Bartekova, Felix Jansen, Qian Li, Johnson Rajasingh, Junjie Xiao
Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells. Increasing evidence has shown the important regulatory effects of EVs in cardiovascular diseases (CVDs). EVs secreted by cardiomyocytes, endothelial cells, fibroblasts, and stem cells play essential roles in pathophysiological processes such as cardiac hypertrophy, cardiomyocyte survival and apoptosis, cardiac fibrosis, and angiogenesis in relation to CVDs...
2017: Theranostics
https://www.readbyqxmd.com/read/29158811/transforming-doxorubicin-into-a-cancer-stem-cell-killer-via-epcam-aptamer-mediated-delivery
#14
Dongxi Xiang, Sarah Shigdar, Andrew G Bean, Matthew Bruce, Wenrong Yang, Motilal Mathesh, Tao Wang, Wang Yin, Phuong Ha-Lien Tran, Hadi Al Shamaileh, Roberto A Barrero, Pei-Zhuo Zhang, Yong Li, Lingxue Kong, Ke Liu, Shu-Feng Zhou, Yingchun Hou, Aina He, Wei Duan
Chemotherapy-resistant cancer stem cells (CSCs) are a major obstacle to the effective treatment of many forms of cancer. To overcome CSC chemo-resistance, we developed a novel system by conjugating a CSC-targeting EpCAM aptamer with doxorubicin (Apt-DOX) to eliminate CSCs. Incubation of Apt-DOX with colorectal cancer cells resulted in high concentration and prolonged retention of DOX in the nuclei. Treatment of tumour-bearing xenograft mice with Apt-DOX resulted in at least 3-fold more inhibition of tumour growth and longer survival as well as a 30-fold lower frequency of CSC and a prolonged longer tumourigenic latency compared with those receiving the same dose of free DOX...
2017: Theranostics
https://www.readbyqxmd.com/read/29158790/synergy-of-purine-scaffold-tlr7-agonist-with-doxorubicin-on-systemic-inhibition-of-lymphoma-in-mouse-model
#15
Dong Gao, Wang Li, Wanmin Wang, Yongguang Cai, Yuhuan Wang, Xiaoling Luo, Chih-Chang Wei
Chemo- and radio-therapy suffer from certain well-recognized drawbacks for lymphoma therapy. Passive immunotherapy with monoclonal antibody has improved outcome for patients with CD20(+) B cell lymphoma, but not for T cell lymphoma. Therefore, novel treatment approaches are clearly required for T cell lymphoma. To date, the combined application targeting TLR7, 8 and 9 has established long-term antitumor immunity. We previously synthesized a purine-scaffold TLR7 agonist named GD5. Here, we report that the intratumoral administration of GD5 combined with doxorubicin (DOX), a conventional chemotherapeutic agent in T cell lymphoma...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29158702/novel-essential-amino-acid-sulfanilamide-hybrid-as-safe-anti-ulcerogenic-agent-with-anti-helicobacter-pylori-activity
#16
Amani S Awaad, Ahmed M Alafeefy, Fatmah A S Alasmary, Reham M El-Meligy, M E Zain, Saleh I Alqasoumi
A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29158521/characterization-and-separation-performance-of-a-novel-polyethersulfone-membrane-blended-with-acacia-gum
#17
Yehia Manawi, Viktor Kochkodan, Ebrahim Mahmoudi, Daniel J Johnson, Abdul Wahab Mohammad, Muataz Ali Atieh
Novel polyethersulfone (PES) membranes blended with 0.1-3.0 wt. % of Acacia gum (AG) as a pore-former and antifouling agent were fabricated using phase inversion technique. The effect of AG on the pore-size, porosity, surface morphology, surface charge, hydrophilicity, and mechanical properties of PES/AG membranes was studied by scanning electron microscopy (SEM), Raman spectroscopy, contact angle and zeta potential measurements. The antifouling -properties of PES/AG membranes were evaluated using Escherichia coli bacteria and bovine serum albumine (BSA)...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158468/evaluating-the-mechanism-and-therapeutic-potential-of-ptc-028-a-novel-inhibitor-of-bmi-1-function-in-ovarian-cancer
#18
Anindya Dey, Xunhao Xiong, Aleia Crim, Shailendra Kumar Dhar Dwivedi, Soumyajit Banerjee Mustafi, Priyabrata Mukherjee, Liangxian Cao, Nadiya Sydorenko, Ramil Baiazitov, Young-Choon Moon, Melissa Dumble, Thomas Davis, Resham Bhattacharya
BMI-1, also known as a stem cell factor, is frequently upregulated in several malignancies. Elevated expression of BMI-1 correlates with poor prognosis and is therefore considered a viable therapeutic target in a number of malignancies including ovarian cancer. Realizing the immense pathological significance of BMI-1, small molecule inhibitors against BMI1 are recently being developed. In the current study, we functionally characterize PTC-028, an orally bioavailable compound that decreases BMI-1 levels by post-translational modification We report that PTC-028 treatment selectively inhibits cancer cells in clonal growth and viability assays whereas normal cells remain unaffected...
November 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29158143/urinary-concentration-and-antimicrobial-activity-of-tobramycin-in-healthy-volunteers-receiving-a-single-oral-dose-of-a-novel-formulation-for-improved-absorption
#19
Maria Loose, Kurt G Naber, Paul Shields, Harald Reinhart, Florian M E Wagenlehner
BACKGROUND: Oral antibiotics for the treatment of UTI are scarce. In this ex vivo phase 1 annex study, clinical safety, urinary concentrations and bactericidal activity of a new formulation for improved oral absorption of tobramycin (Tobrate(TM)) were evaluated. METHODS: The minimal inhibitory and bactericidal concentrations (MIC/MBC) of five test strains, one reference strain and four clinical uropathogenic strains, were determined in cation-adjusted Mueller-Hinton Broth (CAMHB) and in pooled antimicrobial agent-free urine of the subjects at different pH (5...
November 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29158114/early-relapse-for-multiple-myeloma-patients-undergoing-single-autologous-stem-cell-therapy-a-single-center-experience
#20
Holly Lee, Peter Duggan, Ahsan Chaudhry, Paola Neri, Jason Tay, Fariborz Rashid-Kolvear, Nizar J Bahlis, Victor H Jimenez-Zepeda
INTRODUCTION: Multiple myeloma is a heterogeneous disease with diverse clinical courses and patient outcomes. Although the introduction of novel agents has improved the overall survival (OS) of multiple myeloma patients, reports have highlighted that a subset of patients persists who experience early relapse (ER) and whose prognosis is significantly poorer than that of patients with a longer therapy response. METHODS: The purpose of the present study was to understand the effect of ER on OS and identify other predictors of OS...
November 1, 2017: Clinical Lymphoma, Myeloma & Leukemia
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