keyword
MENU ▼
Read by QxMD icon Read
search

rapidly fatal infections

keyword
https://www.readbyqxmd.com/read/28644417/herpes-simplex-virus-establishment-maintenance-and-reactivation-in-vitro-modeling-of-latency
#1
REVIEW
Nikki M Thellman, Steven J Triezenberg
All herpes viruses establish lifelong infections (latency) in their host, and herpes simplex viruses (HSVs) are highly prevalent worldwide. Recurrence of HSV infections contributes to significant disease burden in people and on rare occasion can be fatal. Cell culture models that recapitulate latent infection provide valuable insight on the host processes regulating viral establishment and maintenance of latency. More robust and rapid than infections in live animal studies, advancements in neuronal culture techniques have made the systematic analysis of viral reactivation mechanisms feasible...
June 23, 2017: Pathogens
https://www.readbyqxmd.com/read/28643547/rabies%C3%A2-%C3%A2-epidemiology-pathogenesis-public-health-concerns-and-advances-in-diagnosis-and-control-a-comprehensive-review
#2
Rajendra Singh, Karam Pal Singh, Susan Cherian, Mani Saminathan, Sanjay Kapoor, G B Manjunatha Reddy, Shibani Panda, Kuldeep Dhama
Rabies is a zoonotic, fatal and progressive neurological infection caused by rabies virus of the genus Lyssavirus and family Rhabdoviridae. It affects all warm-blooded animals and the disease is prevalent throughout the world and endemic in many countries except in Islands like Australia and Antarctica. Over 60,000 peoples die every year due to rabies, while approximately 15 million people receive rabies post-exposure prophylaxis (PEP) annually. Bite of rabid animals and saliva of infected host are mainly responsible for transmission and wildlife like raccoons, skunks, bats and foxes are main reservoirs for rabies...
December 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28638939/-consequences-of-autopsies-for-the-living-causes-of-death-in-the-clinical-diagnosis-septic-and-toxic-shock
#3
REVIEW
L Ozretić, A Schwindowski, H-P Dienes, R Büttner, U Drebber, J W U Fries
BACKGROUND: There is reason to believe that the diagnosis of septic and toxic shock, as indicated on the death certificate, cannot be confirmed as the cause of death without autopsy and subsequent histological analysis. The external examination of the corpse can therefore not represent the sole basis for a reliable statement about the infection status of a corpse, e. g. as a prerequisite for embalming. MATERIAL AND METHODS: The validity of autopsy in determining septic and toxic shock as the cause of death is demonstrated in 7 exemplary cases...
June 21, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28638665/a-rare-case-of-septic-shock-secondary-to-emphysematous-hepatitis
#4
Khaled M Nada, Ibrahim El Husseini, Mohammad E Abu Hishmeh, Neerav S Shah, Nadezhda Ibragimova, Riyad Basir
OBJECTIVE: To describe a case of emphysematous hepatitis which is a rare clinical entity, characterized by a fatal, rapidly progressive infection of the liver with a radiological appearance simulating emphysematous pyelonephritis and to help provide more data about the causative organisms and precipitating factors of this pathology. DATA SOURCES AND SYNTHESIS: Relevant literature was reviewed and, to the best of our knowledge, there is limited data regarding the pathogenesis, causative organisms, and management of this condition...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28628941/a-novel-cause-of-chronic-viral-meningoencephalitis-cache-valley-virus
#5
Michael R Wilson, Dan Suan, Andrew Duggins, Ryan D Schubert, Lillian M Khan, Hannah A Sample, Kelsey C Zorn, Aline Rodrigues Hoffman, Anna Blick, Meena Shingde, Joseph L DeRisi
OBJECTIVE: Immunodeficient patients are particularly vulnerable to neuroinvasive infections that can be challenging to diagnose. Metagenomic next-generation sequencing can identify unusual or novel microbes and is therefore well suited for investigating the etiology of chronic meningoencephalitis in immunodeficient patients. METHODS: We present the case of a 34 year-old man with X-linked agammaglobulinemia from Australia suffering from three years of meningoencephalitis that defied an etiologic diagnosis despite extensive conventional testing, including a brain biopsy...
June 19, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28619145/thymol-kills-bacteria-reduces-biofilm-formation-and-protects-mice-against-a-fatal-infection-of-actinobacillus-pleuropneumoniae-strain-l20
#6
Lei Wang, Xueqin Zhao, Chunling Zhu, Xiaojing Xia, Wanhai Qin, Mei Li, Tongzhao Wang, Shijun Chen, Yanzhao Xu, Bolin Hang, Yawei Sun, Jinqing Jiang, Langford Paul Richard, Liancheng Lei, Gaiping Zhang, Jianhe Hu
Actinobacillus pleuropneumoniae is the causative agent of the highly contagious and deadly respiratory infection porcine pleuropneumonia, resulting in serious losses to the pig industry worldwide. Alternative to antibiotics are urgently needed due to the serious increase in antimicrobial resistance. Thymol is a monoterpene phenol and efficiently kills a variety of bacteria. This study found that thymol has strong bactericidal effects on the A. pleuropneumoniae 5b serotype strain, an epidemic strain in China...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28616497/mers-coronavirus-from-discovery-to-intervention
#7
REVIEW
W Widagdo, Nisreen M A Okba, V Stalin Raj, Bart L Haagmans
Middle East respiratory syndrome coronavirus (MERS-CoV) still causes outbreaks despite public awareness and implementation of health care measures, such as rapid viral diagnosis and patient quarantine. Here we describe the current epidemiological picture of MERS-CoV, focusing on humans and animals affected by this virus and propose specific intervention strategies that would be appropriate to control MERS-CoV. One-third of MERS-CoV patients develop severe lower respiratory tract infection and succumb to a fatal outcome; these patients would require effective therapeutic antiviral therapy...
June 2017: One Health
https://www.readbyqxmd.com/read/28614372/intestinal-organoids-model-human-responses-to-infection-by-commensal-and-shiga-toxin-producing-escherichia-coli
#8
Sayali S Karve, Suman Pradhan, Doyle V Ward, Alison A Weiss
Infection with Shiga toxin (Stx) producing Escherichia coli O157:H7 can cause the potentially fatal complication hemolytic uremic syndrome, and currently only supportive therapy is available. Lack of suitable animal models has hindered study of this disease. Induced human intestinal organoids (iHIOs), generated by in vitro differentiation of pluripotent stem cells, represent differentiated human intestinal tissue. We show that iHIOs with addition of human neutrophils can model E. coli intestinal infection and innate cellular responses...
2017: PloS One
https://www.readbyqxmd.com/read/28611446/genome-wide-analysis-of-gene-expression-and-protein-secretion-of-babesia-canis-during-virulent-infection-identifies-potential-pathogenicity-factors
#9
Ramon M Eichenberger, Chandra Ramakrishnan, Giancarlo Russo, Peter Deplazes, Adrian B Hehl
Infections of dogs with virulent strains of Babesia canis are characterized by rapid onset and high mortality, comparable to complicated human malaria. As in other apicomplexan parasites, most Babesia virulence factors responsible for survival and pathogenicity are secreted to the host cell surface and beyond where they remodel and biochemically modify the infected cell interacting with host proteins in a very specific manner. Here, we investigated factors secreted by B. canis during acute infections in dogs and report on in silico predictions and experimental analysis of the parasite's exportome...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28607014/np108-an-antimicrobial-polymer-with-activity-against-methicillin-and-mupirocin-resistant-staphylococcus-aureus
#10
Derry K Mercer, Laura K Katvars, Fiona Hewitt, Daniel W Smith, Jennifer Robertson, Deborah A O'Neil
Staphylococcus aureus is a clinically significant human pathogen that causes infectious diseases ranging from skin and soft tissue infections (SSTI), healthcare associated infections (HAI) to potentially fatal bacteraemia and endocarditis. Nasal carriage of S. aureus, especially persistent carriage, is associated with an increased risk of subsequent infection, particularly nosocomial and surgical site infections (SSI), usually via autoinfection. NP108 is a cationic antimicrobial polymer composed of Generally Recognized as Safe (GRAS) amino acid building blocks...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28606995/synergistic-antibacterial-effect-of-silver-and-ebselen-against-multidrug-resistant-gram-negative-bacterial-infections
#11
Lili Zou, Jun Lu, Jun Wang, Xiaoyuan Ren, Lanlan Zhang, Yu Gao, Martin E Rottenberg, Arne Holmgren
Multidrug-resistant (MDR) Gram-negative bacteria account for a majority of fatal infections, and development of new antibiotic principles and drugs is therefore of outstanding importance. Here, we report that five most clinically difficult-to-treat MDR Gram-negative bacteria are highly sensitive to a synergistic combination of silver and ebselen. In contrast, silver has no synergistic toxicity with ebselen on mammalian cells. The silver and ebselen combination causes a rapid depletion of glutathione and inhibition of the thioredoxin system in bacteria...
June 12, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28594232/revisiting-the-aids-epidemic-in-pakistan-where-we-stand-and-what-we-must-aim-for
#12
Hamza Arshad Dar, Areeba Mubashir, Manal Adil, Aiman Farzeen, Hasaan Naseer, Gohar Ayub, Sajid Mansoor, Aneela Javed
Human Immunodeficiency type 1 (HIV-1) is the major cause of Acquired Immunodeficiency Syndrome (AIDS) in humans, where the immune system totally succumbs to the virus. Large proportion of the AIDS infected belong to developing countries and AIDS prevalence is intensified by severe poverty, malnutrition and famine; fatal illnesses with a scorn shortage of medical amenities complemented with the lack of education and development. Current Pakistani health system setting is in a dire need of improvement. Low literacy rates, high birth rates and associated maternal mortality plus a lack of clean drinking water and appropriate sanitation system have a serious impact on general living conditions contributing to a relatively short life-span...
June 8, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28586594/risk-factors-for-necrotizing-fasciitis-and-its-outcome-at-a-tertiary-care-centre
#13
Yogendra Gupta, Manisha Chhetry, Kamal Raj Pathak, Ranjib Kumar Jha, Nischal Ghimire, Bibhuti Nath Mishra, Navin Kumar Karn, Ganesh Kumar Singh, Jatindra Nath Bhagabati
OBJECTIVE: Necrotizing fasciitis (NF) is a serious and potentially fatal condition where there is rapid progression of inflammation of skin, subcutaneous tissue, and superficial fascia and can be mono-microbial or poly-microbial. The disease is rapidly progressive in nature and if not promptly treated leads to significant morbidity or even mortality. This study was designed to explore the various risk factors commonly present and study the outcome of the disease. METHODS: This was a cross sectional study done in tertiary centre over period of one year from April 2014 to March 2015...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28574091/macrocyclic-peptide-inhibitors-for-the-protein-protein-interaction-of-zaire-ebola-virus-protein-24-and-karyopherin-alpha-5
#14
Xiao Song, Lu-Yi Lu, Toby Passioura, Hiroaki Suga
Ebola virus infection leads to severe hemorrhagic fever in human and non-human primates with an average case fatality rate of 50%. To date, numerous potential therapies are in development, but FDA-approved drugs or vaccines are yet unavailable. Ebola viral protein 24 (VP24) is a multifunctional protein that plays critical roles in the pathogenesis of Ebola virus infection, e.g. innate immune suppression by blocking the interaction between KPNA and PY-STAT1. Here we report macrocyclic peptide inhibitors of the VP24-KPNA5 protein-protein interaction (PPI) by means of the RaPID (Random non-standard Peptides Integrated Discovery) system...
June 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28570275/long-term-culture-of-human-liver-tissue-with-advanced-hepatic-functions
#15
Soon Seng Ng, Anming Xiong, Khanh Nguyen, Marilyn Masek, Da Yoon No, Menashe Elazar, Eyal Shteyer, Mark A Winters, Amy Voedisch, Kate Shaw, Sheikh Tamir Rashid, Curtis W Frank, Nam Joon Cho, Jeffrey S Glenn
A major challenge for studying authentic liver cell function and cell replacement therapies is that primary human hepatocytes rapidly lose their advanced function in conventional, 2-dimensional culture platforms. Here, we describe the fabrication of 3-dimensional hexagonally arrayed lobular human liver tissues inspired by the liver's natural architecture. The engineered liver tissues exhibit key features of advanced differentiation, such as human-specific cytochrome P450-mediated drug metabolism and the ability to support efficient infection with patient-derived inoculums of hepatitis C virus...
June 2, 2017: JCI Insight
https://www.readbyqxmd.com/read/28569141/disease-burden-and-antimicrobial-resistance-of-invasive-group-b-streptococcus-among-infants-in-china-a-protocol-for-a-national-prospective-observational-study
#16
Wenjing Ji, Haiying Liu, Zhengjiang Jin, Aimin Wang, Xiaoping Mu, Xiaosong Qin, Weidong Wang, Chunyan Gao, Yuning Zhu, Xiaodan Feng, Jine Lei, Shangyang She, Lan Jiang, Jing Liu, Shuhua Yang, Zeshi Liu, Gang Li, Qiuhong Li, Dawen Guo, Muhammad Majid Aziz, Ali Hassan Gillani, Yu Fang
BACKGROUND: Group B Streptococcus (GBS) is a cause of neonatal sepsis, pneumonia, and meningitis that can lead to neurological sequelae in infants less than 3 months of age. The GBS disease burden is not known in China, therefore it cannot receive major attention. The main objectives of this study are the evaluation of the incidence of neonatal GBS infection, GBS case-fatality ratio, its serotypes and genotypes, bacterial resistance, clinical treatment and outcomes in China. METHODS: We are conducting a nation-wide, population-based, multi-center, prospective, observational cohort study in China from May 2016 to December 2017...
May 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28551451/a-sandwich-elisa-for-the-detection-of-neuraminidase-of-avian-influenza-a-h7n9-virus
#17
Yueyang Yu, Xi Zhang, Baihui Zhao, Ying Sun, Xiaoguang Zhang, Tian Bai, Jian Lu, Zi Li, Liqi Liu, Dayan Wang, Yuelong Shu, Jianfang Zhou, Kun Qin
Although exhibiting no or low virulence in poultry, avian influenza virus H7N9 has caused around 1400 confirmed human infections in China with a case-fatality rate of 30% since 2013. A highly pathogenic H7N9 virus (HP-H7), with the HA antigenicity distinct from the previous, were recently detected in patients and poultry. Therefore, convenient rapid diagnosis with reliability will allow early antiviral use and management for H7N9 infection. Here, a sandwich ELISA targeting the conserved viral antigen, neuraminidase (NA) was developed...
May 25, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28548485/clinically-relevant-detection-of-streptococcus-pneumoniae-with-dna-antibody-nanostructures
#18
Jinping Wang, May Ching Leong, Eric Zhe Wei Leong, Win Sen Kuan, David Tai Leong
Streptococcus pneumoniae (SP) is a pathogenic bacterium and a major cause of community-acquired pneumonia that could be fatal if left untreated. Therefore, rapid and sensitive detection of SP is crucial to enable targeted treatment during SP infections. In this study, DNA tetrahedron (DNA TH) with a hollow structure is anchored on gold electrodes to construct an electrochemical immunosensor for rapid detection of pneumococcal surface protein A (PspA) peptide and SP lysate from synthetic and actual human samples...
June 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28542123/malaria-surveillance-united-states-2014
#19
Kimberly E Mace, Paul M Arguin
PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is occasionally acquired by persons who have not traveled out of the country through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission...
May 26, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28535809/safety-and-tolerability-of-adjunctive-rosiglitazone-treatment-for-children-with-uncomplicated-malaria
#20
Rosauro Varo, Valerie M Crowley, Antonio Sitoe, Lola Madrid, Lena Serghides, Rubao Bila, Helio Mucavele, Alfredo Mayor, Quique Bassat, Kevin C Kain
BACKGROUND: Despite the widespread use and availability of rapidly acting anti-malarials, the fatality rate of severe malaria in sub-Saharan Africa remains high. Adjunctive therapies that target the host response to malaria infection may further decrease mortality over that of anti-malarial agents alone. Peroxisome proliferator-activated receptor-gamma agonists (e.g. rosiglitazone) have been shown to act on several pathways implicated in the pathogenesis of severe malaria and may improve clinical outcome as an adjunctive intervention...
May 23, 2017: Malaria Journal
keyword
keyword
33354
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"