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spine and Ewing sarcoma

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https://www.readbyqxmd.com/read/27913051/erg-expression-in-multiple-myeloma-a-potential-diagnostic-pitfall
#1
Juliana Knief, Katharina Reddemann, Jan Gliemroth, Swantje Brede, Tobias Bartscht, Christoph Thorns
INTRODUCTION: ERG expression has been described as a frequent event in prostate cancer indicating poor prognosis and promoting oncogenesis. It has also been demonstrated in Ewing's sarcoma, acute myeloid leukemia and acute T-lymphoblastic leukemia but could not be found in other epithelial tumors, Hodgkin's or Non-Hodgkin's lymphoma. We aimed to analyze ERG expression in multiple myeloma, following an index case of a patient with metastases of unknown origin in the spine strongly expressing ERG, which were thought to be of prostatic origin but turned out to be plasmacytic lesions...
November 3, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/27895949/primary-ewing-s-sarcoma-of-the-spine-in-a-two-year-old-boy
#2
Ali J Electricwala, Jaffer T Electricwala
Ewing's Sarcoma (ES) is a highly malignant bone tumour. It may involve any part of the skeleton but the most frequent parts are the ilium and diaphysis of femur and tibia (Alfeeli et al., 2005; Zhu et al., 2012). Primary ES of the spine is extremely rare (Yan et al., 2011). It accounts for only 3.5 to 14.9 percent of all primary bone sarcomas. The age of presentation ranges from 12 to 24 years (median 21 years) (Ferguson, 1999; Sharafuddin et al., 1992; Klimo Jr. et al., 2009). We report an unusual case of primary ES of the spine in a two-year-old boy, who presented to us with paraparesis and features of cauda equina syndrome...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27856382/prognostic-determinants-and-treatment-outcomes-analysis-of-osteosarcoma-and-ewing-sarcoma-of-the-spine
#3
Armin Arshi, Justin Sharim, Don Y Park, Howard Y Park, Hamed Yazdanshenas, Nicholas M Bernthal, Arya N Shamie
BACKGROUND CONTEXT: Osteosarcoma (OGS) and Ewing sarcoma (EWS) are the two classic primary malignant bone tumors. Due to the rarity of these tumors, evidence on demographics, survival determinants, and treatment outcomes for primary disease of the spine are limited and derived from small case series. PURPOSE: To use population-level data to determine the epidemiology and prognostic indicators in patients with OGS and EWS of the osseous spine. STUDY DESIGN/SETTING: Large-scale retrospective study...
November 14, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27752884/factors-affecting-survival-outcomes-of-patients-with-non-metastatic-ewing-s-sarcoma-family-tumors-in-the-spine-a-retrospective-analysis-of-63-patients-in-a-single-center
#4
Wei Wan, Yan Lou, Zhiqi Hu, Ting Wang, Jinsong Li, Yu Tang, Zhipeng Wu, Leqin Xu, Xinghai Yang, Dianwen Song, Jianru Xiao
Little information has been published in the literature regarding survival outcomes of patients with Ewing's sarcoma family tumors (ESFTs) of the spine. The purpose of this study is to explore factors that may affect the prognosis of patients with non-metastatic spinal ESFTs. A retrospective analysis of survival outcomes was performed in patients with non-metastatic spinal ESFTs. Univariate and multivariate analyses were employed to identify prognostic factors for recurrence and survival. Recurrence-free survival (RFS) and overall survival (OS) were defined as the date of surgery to the date of local relapse and death...
October 17, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/26917429/primary-bone-tumors-of-the-spine
#5
A Navas Cañete, H L Bloem, H M Kroon
Primary bone tumors of the spine are less common than metastases or multiple myeloma. Based on the patient's age and the radiologic pattern and topography of the tumor, a very approximate differential diagnosis can be established for an osseous vertebral lesion. This article shows the radiologic manifestations of the principal primary bone tumors of the spine from a practical point of view, based on our personal experience and a review of the literature. If bone metastases, multiple myeloma, lymphomas, hemangiomas, and enostoses are excluded, only eight types of tumors account for 80% of all vertebral tumors...
April 2016: Radiología
https://www.readbyqxmd.com/read/26917407/the-role-of-radiotherapy-in-local-control-of-nonextremity-ewing-sarcomas
#6
Ozlem O Akagunduz, Serra A Kamer, Burcin Kececi, Bengu Demirag, Haldun Oniz, Mehmet Kantar, Nazan Cetingul, Dundar Sabah, Yavuz Anacak
PURPOSE: To evaluate the results of radiotherapy and the prognostic factors affecting local control in nonextremity Ewing sarcomas. METHODS: Between 1995 and 2011, 44 patients with nonextremity Ewing sarcomas were treated with radiotherapy. Tumor localizations were pelvis in 23, spine in 13, thoracic region in 5, and cranium in 3 patients. Tumor size was ≥8 cm in 56.8% of patients. Distant metastases were present in 19 of the patients at the time of diagnosis (43...
March 2016: Tumori
https://www.readbyqxmd.com/read/26883654/do-patients-after-chondrosarcoma-treatment-have-age-appropriate-bone-mineral-density-in-the-long-term
#7
Gerhard M Hobusch, Thomas M Tiefenboeck, Janina Patsch, Christoph Krall, Gerold Holzer
BACKGROUND: In long-term survivors of osteosarcoma and Ewing sarcoma treated with the addition of radio- and chemotherapy, low bone mineral density (BMD) and fractures have been observed, presumably resulting from these adjuvants. Because patients with chondrosarcoma usually are not treated with conventional adjuvant treatment, observation of low BMD in patients with chondrosarcoma presumably would be the result of other mechanisms. However, BMD in patients with a history of chondrosarcoma has not been well characterized...
June 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/26882852/primary-ewing-sarcoma-of-the-lumbar-spine-presenting-as-cauda-equina-syndrome-in-a-pediatric-patient
#8
Cahit Kafadar, Onur Levent Ulusoy, Ersin Ozturk, Ayhan Mutlu
No abstract text is available yet for this article.
September 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/26847997/ct-and-clinical-findings-of-peripheral-primitive-neuroectodermal-tumour-in-children
#9
Huijuan Xiao, Fengchang Bao, Hongna Tan, Bo Wang, Wei Liu, Jianbo Gao, Xianzheng Gao
OBJECTIVE: To describe the clinical, CT and pathological findings of paediatric peripheral primitive neuroectodermal tumours (pPNETs) to enhance the recognition of these rare tumours. METHODS: The clinical, CT and pathological findings of 18 paediatric patients with pPNETs confirmed by biopsy or surgical pathology were retrospectively reviewed. RESULTS: The age of these 18 paediatric patients with pPNETs ranged from 4 months to 15 years, with a mean age of 7...
2016: British Journal of Radiology
https://www.readbyqxmd.com/read/26776236/a-rare-cause-of-low-back-pain-primary-ewing-sarcoma-of-the-lumbar-spine
#10
Hatice Resorlu, Adem B Aras, Coskun Zateri, Ferdi Goksel
No abstract text is available yet for this article.
July 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/26677423/computer-assisted-navigation-during-an-anterior-posterior-en-bloc-resection-of-a-sacral-tumor
#11
Sami Al Eissa, Amro F Al-Habib, Faisal R Jahangiri
Previously, a computer-based navigation system has not been used routinely for en-bloc resection of sacral tumors. In order to improve the accuracy of tumor resection, O-arm navigation was used to join anterior and posterior osteotomies during an en-bloc resection of a sacral Ewing's sarcoma. This case study describes the technique for en-bloc resection of a sacral Ewing's sarcoma guided by O-arm computer navigation and intraoperative neurophysiological monitoring (IONM). An 18-year-old male presented with weakness in his left lower extremity...
2015: Curēus
https://www.readbyqxmd.com/read/26335676/reconstruction-of-the-upper-cervical-spine-using-a-personalized-3d-printed-vertebral-body-in-an-adolescent-with-ewing-sarcoma
#12
Nanfang Xu, Feng Wei, Xiaoguang Liu, Liang Jiang, Hong Cai, Zihe Li, Miao Yu, Fengliang Wu, Zhongjun Liu
STUDY DESIGN: Case report. OBJECTIVE: To describe a three-dimensional (3D) printed axial vertebral body used in upper cervical spine reconstruction after a C2 Ewing sarcoma resection in an adolescent boy. SUMMARY OF BACKGROUND DATA: Ewing sarcoma is a malignant musculoskeletal neoplasm with a peak incidence in adolescents. Cervical spine as the primary site of the tumor has been related to a worse prognosis. Tumor resection is particularly challenging in the atlantoaxial region due to complexity of the anatomy, necessity for extensive resection according to oncological principles, and a lack of specialized implants for reconstruction...
January 2016: Spine
https://www.readbyqxmd.com/read/26308634/the-neurological-compromised-spine-due-to-ewing-sarcoma-what-first-surgery-or-chemotherapy-therapy-survival-and-neurological-outcome-of-15-cases-with-primary-ewing-sarcoma-of-the-vertebral-column
#13
Lida Mirzaei, Suzanne E J Kaal, Hendrik W B Schreuder, Ronald H M A Bartels
BACKGROUND: The vertebral column is an infrequent site of primary involvement in Ewing sarcoma. Yet when Ewing sarcoma is found in the spine, the urge for decompression is high because of the often symptomatic compression of neural structures. It is unclear in alleviating a neurological deficit whether chemotherapy is preferred over decompressive laminectomy. OBJECTIVE: To underline, in this case series, the efficiency of initial chemotherapy before upfront surgery in the setting of high-grade spinal cord or cauda equina compression of primary Ewing sarcoma...
November 2015: Neurosurgery
https://www.readbyqxmd.com/read/26166072/systematic-review-of-en-bloc-resection-in-the-management-of-ewing-s-sarcoma-of-the-mobile-spine-with-respect-to-local-control-and-disease-free-survival
#14
REVIEW
Mathew David Sewell, Kimberly-Anne Tan, Nasir A Quraishi, Corina Preda, Peter P Varga, Richard Williams
There is no consensus on the optimal method of local control in Ewing's sarcoma (ES) of the mobile spine. Recent reports have suggested that en bloc resection may improve local control and survival. The authors therefore performed a systematic review to answer the following questions: (1) What is the outcome of en bloc resection for ES of the mobile spine with respect to local control and disease-free survival (DFS)? (2) How should residual ES of the mobile spine be treated?Inclusion criteria were articles published between the years 1960 and 2014 in English that contained more than five patients...
July 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25993237/chemotherapy-for-bone-sarcomas-in-adults-the-md-anderson-experience
#15
REVIEW
Robert S Benjamin, Michael J Wagner, J Andrew Livingston, Vinod Ravi, Shreyaskumar R Patel
Increasing age is an adverse prognostic factor in the treatment of primary bone tumors. There are few published data on treatment of primary bone tumors in adults. This paper presents data from the Department of Sarcoma Medical Oncology at The University of Texas MD Anderson Cancer Center, summarizing our treatment results. To treat primary osteosarcoma, we used 90 mg/m2 of doxorubicin as a continuous intravenous infusion over 48 to 96 hours and 120 to 160 mg/m2 of cisplatin intravenously or intra-arterially...
2015: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/25954672/unusual-presentation-of-a-primary-ewing-s-sarcoma-of-the-spine-with-paraplegia-a-case-report
#16
Karthik Kailash Kannan, Rajkumar Jayachandran Sundarapandian, Vignesh Jayabalan Surulivel
Ewing's sarcoma is a primary malignancy of the bone affecting individuals in the second decade of life. Primary sarcomas of the spine are rare and the occurrence of Primary Ewing's sarcoma in the spine is very rare. Ewing's sarcoma occurring in the spine is divided into two types, Ewing's sarcoma of sacral spine which are very aggressive with poor prognosis and Ewing's sarcoma of the non sacral spine which is an extremely rare occurrence. Patient may present with neurological deficit when the tumour extends into the spinal canal causing spinal cord compression...
March 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25802527/a-unique-case-of-primary-ewing-s-sarcoma-of-the-cervical-spine-in-a-53-year-old-male-a-case-report-and-review-of-the-literature
#17
Marshall T Holland, Oliver E Flouty, Liesl N Close, Chandan G Reddy, Matthew A Howard
Extraskeletal Ewing's sarcoma (EES) is a rare presentation, representing only 15% of all primary Ewing's sarcoma cases. Even more uncommon is EES presenting as a primary focus in the spinal canal. These rapidly growing tumors often present with focal neurological symptoms of myelopathy or radiculopathy. There are no classic characteristic imaging findings and thus the physician must keep a high index of clinical suspicion. Diagnosis can only be definitively made by histopathological studies. In this report, we discuss a primary cervical spine EES in a 53-year-old man who presented with a two-month history of left upper extremity pain and acute onset of weakness...
2015: Case Reports in Medicine
https://www.readbyqxmd.com/read/25557999/developing-a-prognostic-model-for-localized-ewing-sarcoma-family-of-tumors-a-single-institutional-experience-of-224-cases-treated-with-uniform-chemotherapy-protocol
#18
Bivas Biswas, S Rastogi, S A Khan, N K Shukla, S V S Deo, S Agarwala, B K Mohanti, M C Sharma, Sreenivas Vishnubhatla, S Bakhshi
BACKGROUND: Data on patients with localized Ewing sarcoma family of tumors (ESFT) who have received a uniform chemotherapy protocol are minimal. METHODS: This is a single institutional review of patients with ESFT treated between June 2003 and November 2011. RESULTS: 224/374 (60%) patients with ESFT presented with localized disease; median age was 15 years (range: 0.1-55). Ninety-nine patients underwent surgery of which 50 received adjuvant radiotherapy; 80 patients received radical radiotherapy following neoadjuvant chemotherapy...
May 2015: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25006293/a-rare-case-of-translocation-12-22-p13-q-in-ewing-s-sarcoma
#19
S K Kousar Jahan, Mangala Gowri Mayanna, B L Kavitha, Akkamahadevi Patil, Prasanna Kumari
Cytogenetic or immunohistochemical studies are often required to differentiate Ewing's sarcoma (ES) from other small round cell tumors. Herein we report a case of 13-year-old boy who presented with a large presacral lesion. Hemogram and biochemical parameters were normal except lactate dehydrogenase showing value of 96.40/IU/L, magnetic resonance imaging of the spine showed a large mass in presacral lesion (8 cm × 7 cm × 9 cm), with destruction of the sacrum (S2 S3 and S4) with interspinal extension. Bone scan showed multiple pelvic bone lesions, radiograph of chest, ultrasound of abdomen, pelvis and electrocardiogram were within normal limits...
January 2014: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/24896744/primary-tumors-of-the-spine
#20
REVIEW
Sebnem Orguc, Remide Arkun
Spinal tumors consist of a large spectrum of various histologic entities. Multiple spinal lesions frequently represent known metastatic disease or lymphoproliferative disease. In solitary lesions primary neoplasms of the spine should be considered. Primary spinal tumors may arise from the spinal cord, the surrounding leptomeninges, or the extradural soft tissues and bony structures. A wide variety of benign neoplasms can involve the spine including enostosis, osteoid osteoma, osteoblastoma, aneurysmal bone cyst, giant cell tumor, and osteochondroma...
July 2014: Seminars in Musculoskeletal Radiology
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