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https://www.readbyqxmd.com/read/28278190/sickness-behavior-in-feverish-children-is-independent-of-the-severity-of-fever-an-observational-multicenter-study
#1
François Corrard, Christian Copin, Alain Wollner, Annie Elbez, Véronique Derkx, Stéphane Bechet, Corinne Levy, Michel Boucherat, Robert Cohen
BACKGROUND. OBJECTIVES: Behavioral changes in a febrile child are usually considered to stem from the fever. We studied sickness behavior (SB) in terms of its clinical components and its relation to fever. METHODS: This observational, multicenter study included children aged 6 months to 3 years who were either febrile (fever ≥12 hours, ≥ 39°C and ≥38°C at inclusion) or non-febrile and well. The child had to have been awake for the 2 hours preceding the consultation and cared for by the parent who brought him/her to the doctor...
2017: PloS One
https://www.readbyqxmd.com/read/28254724/fast-algal-eco-toxicity-assessment-influence-of-light-intensity-and-exposure-time-on-chlorella-vulgaris-inhibition-by-atrazine-and-dcmu
#2
Alexandre Camuel, Benoit Guieysse, Cynthia Alcántara, Quentin Béchet
In order to develop a rapid assay suitable for algal eco-toxicity assessments under conditions representative of natural ecosystems, this study evaluated the short-term (<1h) response of algae exposed to atrazine and DCMU using oxygen productivity measurements. When Chlorella vulgaris was exposed to these herbicides under 'standard' low light intensity (as prescribed by OECD201 guideline), the 20min-EC50 values recorded via oxygen productivity (atrazine: 1.32±0.07μM; DCMU: 0.31±0.005μM) were similar the 96-h EC50 recorded via algal growth (atrazine: 0...
February 28, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28248242/a-proof-of-concept-to-bridge-the-gap-between-mass-spectrometry-imaging-protein-identification-and-relative-quantitation-msi-lc-ms-ms-lf
#3
Laëtitia Théron, Delphine Centeno, Cécile Coudy-Gandilhon, Estelle Pujos-Guillot, Thierry Astruc, Didier Rémond, Jean-Claude Barthelemy, Frédéric Roche, Léonard Feasson, Michel Hébraud, Daniel Béchet, Christophe Chambon
Mass spectrometry imaging (MSI) is a powerful tool to visualize the spatial distribution of molecules on a tissue section. The main limitation of MALDI-MSI of proteins is the lack of direct identification. Therefore, this study focuses on a MSI~LC-MS/MS-LF workflow to link the results from MALDI-MSI with potential peak identification and label-free quantitation, using only one tissue section. At first, we studied the impact of matrix deposition and laser ablation on protein extraction from the tissue section...
October 26, 2016: Proteomes
https://www.readbyqxmd.com/read/28219340/very-high-mhc-class-iib-diversity-without-spatial-differentiation-in-the-mediterranean-population-of-greater-flamingos
#4
Mark A F Gillingham, Arnaud Béchet, Alexandre Courtiol, Manuel Rendón-Martos, Juan A Amat, Boudjéma Samraoui, Ortaç Onmuş, Simone Sommer, Frank Cézilly
BACKGROUND: Selective pressure from pathogens is thought to shape the allelic diversity of major histocompatibility complex (MHC) genes in vertebrates. In particular, both local adaptation to pathogens and gene flow are thought to explain a large part of the intraspecific variation observed in MHC allelic diversity. To date, however, evidence that adaptation to locally prevalent pathogens maintains MHC variation is limited to species with limited dispersal and, hence, reduced gene flow...
February 20, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28201740/how-long-does-wolbachia-remain-on-board
#5
Marc Bailly-Bechet, Patricia Martins-Simões, Gergely Szöllősi, Gladys Mialdea, Marie-France Sagot, Sylvain Charlat
No abstract text is available yet for this article.
February 13, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28067913/impaired-h3k36-methylation-defines-a-subset-of-head-and-neck-squamous-cell-carcinomas
#6
Simon Papillon-Cavanagh, Chao Lu, Tenzin Gayden, Leonie G Mikael, Denise Bechet, Christina Karamboulas, Laurie Ailles, Jason Karamchandani, Dylan M Marchione, Benjamin A Garcia, Ilan Weinreb, David Goldstein, Peter W Lewis, Octavia Maria Dancu, Sandeep Dhaliwal, William Stecho, Christopher J Howlett, Joe S Mymryk, John W Barrett, Anthony C Nichols, C David Allis, Jacek Majewski, Nada Jabado
Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs) are deadly and common cancers. Recent genomic studies implicate multiple genetic pathways, including cell signaling, cell cycle and immune evasion, in their development. Here we analyze public data sets and uncover a previously unappreciated role of epigenome deregulation in the genesis of 13% of HPV-negative HNSCCs. Specifically, we identify novel recurrent mutations encoding p.Lys36Met (K36M) alterations in multiple H3 histone genes...
January 9, 2017: Nature Genetics
https://www.readbyqxmd.com/read/27978898/-risk-factors-for-long-term-result-of-endovascular-treatment-for-auto-immune-disease-related-abdominal-aorta-pseudo-aneurysm
#7
W Ye, X Di, Q Liu, Y J Li, Y H Zheng, R Zeng, X J Song, Z L Liu, C W Liu
Objective: To summarize results of endovascular treatment for auto-immune disease related abdominal aorta pseudo-aneurysm(AIPA), and to analysis clinical predictors of long term major adverse clinical events(MACE). Methods: Retrospectively collected endovascular treatment for AIPA cases in Peking Union Medical College Hospital within 2000 to 2015. Twenty-nine cases with AIPA treated by endovascular therapy were enrolled in this study. Twenty five cases were male, range from 23 to 67 years old, mean age was (39...
December 6, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27938463/effectiveness-of-endoscopic-cricopharyngeal-myotomy-in-adults-with-neurological-disease-systematic-review
#8
REVIEW
Ó Gilheaney, P Kerr, S Béchet, M Walshe
OBJECTIVE: To determine the effectiveness of endoscopic cricopharyngeal myotomy on upper oesophageal sphincter dysfunction in adults with upper oesophageal sphincter dysfunction and neurological disease. DATA SOURCES: Published and unpublished studies with a quasi-experimental design investigating endoscopic cricopharyngeal myotomy effects on upper oesophageal sphincter dysfunction in humans were considered eligible. Electronic databases, grey literature and reference lists of included studies were systematically searched...
December 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27912317/production-of-bacillus-amyloliquefaciens-og-and-its-metabolites-in-renewable-media-valorisation-for-biodiesel-production-and-p-xylene-decontamination
#9
Augusto Etchegaray, François Coutte, Gabrielle Chataigné, Max Béchet, Ramon H Z Dos Santos, Valérie Leclère, Philippe Jacques
Biosurfactants are important in many areas; however, costs impede large-scale production. This work aimed to develop a global sustainable strategy for the production of biosurfactants by a novel strain of Bacillus amyloliquefaciens. Initially, Bacillus sp. strain 0G was renamed B. amyloliquefaciens subsp. plantarum (syn. Bacillus velezensis) after analysis of the gyrA and gyrB DNA sequences. Growth in modified Landy's medium produced 3 main recoverable metabolites: surfactin, fengycin, and acetoin, which promote plant growth...
January 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/27883016/sexual-display-complexity-varies-non-linearly-with-age-and-predicts-breeding-status-in-greater-flamingos
#10
Charlotte Perrot, Arnaud Béchet, Céline Hanzen, Antoine Arnaud, Roger Pradel, Frank Cézilly
The long-lived greater flamingo (Phoenicopterus roseus) is famous for performing conspicuous group displays during which adults try to acquire a new mate each year with varying success. We examined variation in the sexual display complexity (SDC) of wild flamingos aged between 4 and 37 yrs. SDC was defined as the product of richness (the number of different display movements) and versatility (the number of transitions between movements) within a 5 min behavioral sequence. In both sexes, date in the pairing season had a linear and positive effect on SDC, whereas age had a quadratic effect, with SDC increasing until about age 20yrs, and declining afterwards...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27817170/hospital-pharmacists-seen-through-the-eyes-of-physicians-qualitative-semi-structured-interviews
#11
Clare Béchet, Renaud Pichon, André Giordan, Pascal Bonnabry
Background Pharmacist-physician collaboration can lead to many positive outcomes. However, collaboration between healthcare providers is complex and rarely performed optimally. Objectives To study physician-pharmacist collaboration in hospital settings, from the physician's point of view. Setting Eight regional non-teaching hospital facilities, within a local area of northwest Switzerland, supplied by an independent central pharmacy. Method Physicians were sampled using a maximal variation purposive method...
December 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27738757/high-throughput-strategies-for-the-discovery-and-engineering-of-enzymes-for-biocatalysis
#12
REVIEW
Philippe Jacques, Max Béchet, Muriel Bigan, Delphine Caly, Gabrielle Chataigné, François Coutte, Christophe Flahaut, Egon Heuson, Valérie Leclère, Didier Lecouturier, Vincent Phalip, Rozenn Ravallec, Pascal Dhulster, Rénato Froidevaux
Innovations in novel enzyme discoveries impact upon a wide range of industries for which biocatalysis and biotransformations represent a great challenge, i.e., food industry, polymers and chemical industry. Key tools and technologies, such as bioinformatics tools to guide mutant library design, molecular biology tools to create mutants library, microfluidics/microplates, parallel miniscale bioreactors and mass spectrometry technologies to create high-throughput screening methods and experimental design tools for screening and optimization, allow to evolve the discovery, development and implementation of enzymes and whole cells in (bio)processes...
February 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/27699134/full-field-interferometry-for-counting-and-differentiating-aquatic-biotic-nanoparticles-from-laboratory-to-tara-oceans
#13
Martine Boccara, Yasmina Fedala, Catherine Venien Bryan, Marc Bailly-Bechet, Chris Bowler, Albert Claude Boccara
There is a huge abundance of viruses and membrane vesicles in seawater. We describe a new full-field, incoherently illuminated, shot-noise limited, common-path interferometric detection method that we couple with the analysis of Brownian motion to detect, quantify, and differentiate biotic nanoparticles. We validated the method with calibrated nanoparticles and homogeneous DNA or RNA viruses. The smallest virus size that we characterized with a suitable signal-to-noise ratio was around 30 nm in diameter. Analysis of Brownian motions revealed anisotropic trajectories for myoviruses...
September 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27595445/comparative-impact-of-pneumococcal-conjugate-vaccines-on-pneumococcal-meningitis-according-to-underlying-conditions
#14
Robert Cohen, Emmanuelle Varon, Stéphane Béchet, Stéphane Bonacorsi, Corinne Levy
BACKGROUND: Several underlying conditions increase the risk of pneumococcal meningitis (PM) in childhood. Patients with these diseases are initially considered as an important target of pneumococcal conjugate vaccines (PCVs). Limited data are available for PM in children with underlying conditions. To understand the benefits of PCV7 followed by PCV13 in this vulnerable population, we analyzed the data for a large cohort of pediatric patients with PM in France from 2001 to 2014. METHODS: We conducted hospital-based active surveillance with 227 pediatric wards working with 168 microbiology departments throughout France...
September 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27530728/diagnostic-accuracy-of-the-modified-evan-s-blue-dye-test-in-detecting-aspiration-in-patients-with-tracheostomy-a-systematic-review-of-the-evidence
#15
Sibylle Béchet, Fiona Hill, Órla Gilheaney, Margaret Walshe
Oropharyngeal aspiration (OPA) is a common occurrence in patients with tracheostomy. The modified Evan's blue dye test (MEBDT) is an easily administered bedside procedure for the assessment of tracheostomised patients. However, studies evaluating the diagnostic accuracy of the MEBDT reach conflicting results. Therefore, we conducted a systematic review to determine the overall accuracy of the MEBDT in detecting OPA in adults with tracheostomy. The search strategy incorporated searching electronic databases, checking reference lists and citations and retrieving unpublished data...
August 16, 2016: Dysphagia
https://www.readbyqxmd.com/read/27401173/senca-a-multilayered-codon-model-to-study-the-origins-and-dynamics-of-codon-usage
#16
Fanny Pouyet, Marc Bailly-Bechet, Dominique Mouchiroud, Laurent Guéguen
Gene sequences are the target of evolution operating at different levels, including the nucleotide, codon, and amino acid levels. Disentangling the impact of those different levels on gene sequences requires developing a probabilistic model with three layers. Here we present SENCA (site evolution of nucleotides, codons, and amino acids), a codon substitution model that separately describes 1) nucleotide processes which apply on all sites of a sequence such as the mutational bias, 2) preferences between synonymous codons, and 3) preferences among amino acids...
2016: Genome Biology and Evolution
https://www.readbyqxmd.com/read/27378730/ube2d2-is-not-involved-in-murf1-dependent-muscle-wasting-during-hindlimb-suspension
#17
Polge Cécile, Nathalie Koulmann, Agnès Claustre, Marianne Jarzaguet, Bernard Serrurier, Lydie Combaret, Daniel Béchet, Xavier Bigard, Didier Attaix, Daniel Taillandier
The Ubiquitin Proteasome System (UPS) is mainly responsible for the increased protein breakdown observed in muscle wasting. The E3 ligase MuRF1 is so far the only enzyme known to direct the main contractile proteins for degradation (i.e. troponin I, myosin heavy chains and actin). However, MuRF1 does not possess any catalytic activity and thus depends on the presence of a dedicated E2 for catalyzing the covalent binding of polyubiquitin (polyUb) chains on the substrates. The E2 enzymes belonging to the UBE2D family are commonly used for in vitro ubiquitination assays but no experimental data suggesting their physiological role as bona fide MuRF1-interacting E2 enzymes are available...
July 1, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27330068/esbl-producing-escherichia-coli-st131-versus-non-st131-evolution-and-risk-factors-of-carriage-among-french-children-in-the-community-between-2010-and-2015
#18
André Birgy, Corinne Levy, Philippe Bidet, Franck Thollot, Véronique Derkx, Stéphane Béchet, Patricia Mariani-Kurkdjian, Robert Cohen, Stéphane Bonacorsi
OBJECTIVES: The objective of this study was to evaluate the evolution and risk factors of ESBL-producing Enterobacteriaceae (ESBL-E) carriage in children in the community for a long period distinguishing ST131 and non-ST131 Escherichia coli. PATIENTS AND METHODS: In this prospective study, rectal samples were obtained from children aged 6-24 months by community paediatricians between 2010 and 2015. Demographic characteristics and risk factors for ESBL-E carriage were collected...
October 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27239420/docosahexaenoic-acid-supplementation-prior-to-fasting-prevents-muscle-atrophy-in-mice
#19
Christiane Deval, Frédéric Capel, Brigitte Laillet, Cécile Polge, Daniel Béchet, Daniel Taillandier, Didier Attaix, Lydie Combaret
BACKGROUND: Muscle wasting prevails in numerous diseases (e.g. diabetes, cardiovascular and kidney diseases, COPD,…) and increases healthcare costs. A major clinical issue is to devise new strategies preventing muscle wasting. We hypothesized that 8-week docosahexaenoic acid (DHA) supplementation prior to fasting may preserve muscle mass in vivo. METHODS: Six-week-old C57BL/6 mice were fed a DHA-enriched or a control diet for 8 weeks and then fasted for 48 h...
December 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27239408/ube2b-is-implicated-in-myofibrillar-protein-loss-in-catabolic-c2c12-myotubes
#20
Cécile Polge, Roza Leulmi, Marianne Jarzaguet, Agnes Claustre, Lydie Combaret, Daniel Béchet, Anne-Elisabeth Heng, Didier Attaix, Daniel Taillandier
BACKGROUND: Skeletal muscle protein loss is an adaptive response to various patho-physiological situations, and the ubiquitin proteasome system (UPS) is responsible for the degradation of the bulk of muscle proteins. The role of E2 ubiquitin-conjugating enzymes is still poorly understood in skeletal muscle. METHODS: We screened for E2s expression levels in C2C12 myotubes submitted to the catabolic glucocorticoid dexamethasone (Dex). RESULTS: One micromolar Dex induced an accumulation of proteasome substrates (polyUb conjugates) and an overexpression of the muscle-specific E3 ligase MuRF1 and of six E2 enzymes, UBE2A, UBE2B, UBE2D1, UBE2D2, UBE2G1, and UBE2J1...
June 2016: Journal of Cachexia, Sarcopenia and Muscle
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