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Ashutosh Singh, Pradeep Kumar Singh, Anil Kumar, Jagdish Chander, Geetika Khanna, Pradip Roy, Jacques F Meis, Anuradha Chowdhary
Melanized or black fungi are a heterogeneous group of fungi causing cutaneous to systemic diseases with high mortality. These fungi are rarely reported as agent of human infections primarily due to difficulties in their classical identification. In this study we examined using molecular methods and MALDI-TOF MS the diversity of melanized fungi (MF) isolated from patients in 19 medical centers in India. Overall, during a 4-year period, 718 (5.3%) clinical specimens yielded MF. Of these, 72 (10%) isolates had clinical significance and were identified primarily by sequencing the ITS and LSU regions...
January 18, 2017: Journal of Clinical Microbiology
A Serda Kantarcioglu, Josep Guarro, Sybren De Hoog, Hulya Apaydin, Nuri Kiraz
Cladophialophora bantiana is a phaeoid fungus that only rarely has been isolated from sources other than the human brain. It has a particular tropism for the central nervous system (CNS). We have integrated and updated large-scale data related to several aspects of C. Bantiana and reviewed all the available reports on its cerebral infections, focusing on their geographical distribution, infection routes, immune status of infected individuals, type and location of infections, clinical manifestations and treatment and outcome, briefly looking over the spectrum of other disease entities associated with C...
December 22, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Partha Roy, S Prasanna, Dudhat Vaibhav Laxmikant, C N Chaudhari
No abstract text is available yet for this article.
October 2016: Medical Journal, Armed Forces India
L F A Guimarães, M Halpern, A S de Lemos, E F de Gouvêa, R T Gonçalves, M A A da Rosa Santos, M Nucci, G Santoro-Lopes
INTRODUCTION: Invasive fungal disease (IFD) is an important complication after solid organ transplantation (SOT). A marked geographic variation in the epidemiology of IFD after kidney transplantation (KT) has been suggested by the results of previous studies. Nevertheless, data from Latin American centers are scarce. OBJECTIVE: This study sought to describe the epidemiology of IFD at a Brazilian KT center. METHODS: This study was a retrospective single-center cohort study that included patients who underwent KT between 1998 and 2009 and were followed up until July 2015...
September 2016: Transplantation Proceedings
Vipul M Patel, Bhavin Kapadiya, Viral Shah
Phaeohyphomycosis is a term used to describe infections caused by dematiaceous fungi, i.e. fungi which contain melanin in their cell wall. Cladophialophora bantiana has been implicated to cause brain abscess in immunocompromised patients. Infection caused by Cladophialophora bantiana in an immunocompetent host is relatively rare. Surgical site infection at abdominal subcutaneous tissue caused by Cladophialophora bantiana was noted in this case, which was rarely reported.
May 2016: Journal of the Association of Physicians of India
Francisca Hernández-Hernández, Jaime Vargas-Arzola, Oliver Pedro Ríos-Cruz, Erika Córdova-Martínez, Patricia Manzano-Gayosso, Aristeo Segura-Salvador
Chromoblastomycosis is a chronic infection, caused by pigmented fungi affecting skin and subcutaneous tissues characterized by verrucous nodules or plaques. Fonsecaea pedrosoi and Cladophialophora carrionii are the prevalent agents in the endemic areas. Phoma is an uncommon agent of human infection and involved mainly with phaeohyphomycosis cases. The case of a patient with a history of laceration in foot followed by verrucous aspect and scaly lesions, which had evolved for 27 years is presented. On physical examination disease was clinically compatible with chromoblastomycosis and the microscopic examination of scales showed fumagoid cells...
October 7, 2016: Enfermedades Infecciosas y Microbiología Clínica
Stefanie Desmet, Liesbeth Smets, Katrien Lagrou, Inge Derdelinckx, Jeroen Neyt, Johan Maertens, Raf Sciot, Philip Demaerel, Bert Bammens
Cladophialophora bantiana is a neurotropic dematiaceous fungus which rarely causes disseminated disease. We report a case of proven C. bantiana osteomyelitis in a renal transplant recipient, complicated with probable cerebral disease. Stable disease was reached after combined antifungal therapies, immune enhancement and amputation of the infected lower limb.
June 2016: Medical Mycology Case Reports
Chee Sian Kuan, Chun Yoong Cham, Gurmit Singh, Su Mei Yew, Yung-Chie Tan, Pei-Sin Chong, Yue Fen Toh, Nadia Atiya, Shiang Ling Na, Kok Wei Lee, Chee-Choong Hoh, Wai-Yan Yee, Kee Peng Ng
Cladophialophora bantiana is a dematiaceous fungus with a predilection for causing central nervous system (CNS) infection manifesting as brain abscess in both immunocompetent and immunocompromised patients. In this paper, we report comprehensive genomic analyses of C. bantiana isolated from the brain abscess of an immunocompetent man, the first reported case in Malaysia and Southeast Asia. The identity of the fungus was determined using combined morphological analysis and multilocus phylogeny. The draft genome sequence of a neurotrophic fungus, C...
2016: PloS One
A Serda Kantarcioglu, Josep Guarro, G Sybren de Hoog, Hulya Apaydin, Nuri Kiraz, Ilker Inanç Balkan, Resat Ozaras
BACKGROUND: Cladophialophora bantiana is a melanised mold with a pronounced tropism for the central nervous system, almost exclusively causing human brain abscesses. CASE REPORT: We describe a case of cerebral infection by this fungus in an otherwise healthy 28-year-old coal-miner. Environmental occurrence, route of entry, and incubation period of this fungus are unknown, but our case is informative in that the first symptoms occurred about eight weeks after known traumatic inoculation...
October 2016: Revista Iberoamericana de Micología
Erika Usui, Yusuke Takashima, Kazuhiko Narisawa
A novel species of Cladophialophora is herein described from the natural environment of secondary forest soil in Japan, which was able to be colonized by the host plant root. Morphological observations indicated that the isolate is distinct from previously identified species, and, thus, is described as the new species, C. inabaensis sp. nov.
September 29, 2016: Microbes and Environments
Barbara Blasi, Caroline Poyntner, Tamara Rudavsky, Francesc X Prenafeta-Boldú, Sybren De Hoog, Hakim Tafer, Katja Sterflinger
A collection of 163 strains of black yeast-like fungi from the CBS Fungal Biodiversity Center (Utrecht, The Netherlands), has been screened for the ability to grow on hexadecane, toluene and polychlorinated biphenyl 126 (PCB126) as the sole carbon and energy source. These compounds were chosen as representatives of relevant environmental pollutants. A microtiter plate-based culture assay was set up in order to screen the fungal strains for growth on the selected xenobiotics versus glucose, as a positive control...
March 15, 2016: Geomicrobiology Journal
S Deng, W Pan, W Liao, G S de Hoog, A H G Gerrits van den Ende, R G Vitale, H Rafati, M Ilkit, A H Van der Lee, A J M M Rijs, P E Verweij, S Seyedmousavi
Primary central nervous system phaeohyphomycosis is a fatal fungal infection due mainly to the neurotropic melanized fungiCladophialophora bantiana,Rhinocladiella mackenziei, andExophiala dermatitidis.Despite the combination of surgery with antifungal treatment, the prognosis continues to be poor, with mortality rates ranging from 50 to 70%. Therefore, a search for a more-appropriate therapeutic approach is urgently needed. Ourin vitrostudies showed that with the combination of amphotericin B and flucytosine against these species, the median fractional inhibitory concentration (FIC) indices for strains ranged from 0...
April 2016: Antimicrobial Agents and Chemotherapy
Prashant Verma, Somenath Karmakar, Deepika Pandhi, Archana Singal, Pravesh Yadav, Shashi Khare
A 45-year-old accountant residing in Delhi, India, presented to our dermatology clinic with a small asymptomatic plaque on the little finger of his left hand of 3 months' duration. The onset of the lesion was insidious and gradually progressed to 4 cm across at the time of his first visit. The patient had undergone renal transplantation twice (the first procedure 3 months prior and the second 18 months prior). Since then, he had been receiving cyclosporine A (400 mg daily) and prednisolone (40 mg) daily in immunosuppessive doses...
May 2015: Skinmed
Anza Khader, Betsy Ambooken, Manikoth Payyanadan Binitha, Saji Francis, Ashokan K Kuttiyil, Deepthi Nalini Sureshan
Cladophialophora bantiana is a neurotropic dematiaceous fungus which only rarely affects the skin. We report a case of disseminated cutaneous phaeohyphomycosis caused by Cladophialophora bantiana in an immunocompromised female who presented with multiple pyogenic granuloma-like nodules, dermatophytosis-like plaque, and subcutaneous cysts on the upper and lower extremities without systemic involvement. Biopsy revealed black yeasts resembling sclerotic bodies and culture yielded irregular, velvety, grey colonies with black reverse...
September 2015: Indian Journal of Dermatology, Venereology and Leprology
Merja Rantala, Stella Attia, Pirkko Koukila-Kähkölä, Sybren de Hoog, Marjukka Anttila, Terttu Katila
We present an unusual equine endometritis case associated with Cladophialophora bantiana in a 15-year-old mare. The mare displayed infertility and uterine fluid accumulation with numerous black, hairy granules. Microscopically, the fluid revealed numerous septate, dark fungal hyphae and conidia in chains. Culture yielded C. bantiana (CBS 138271); the species was confirmed by internal transcribed spacer (ITS) sequencing. Treatment was unsuccessful. C. bantiana causes cerebral phaeohyphomycosis in humans, while animal cases are rare...
September 2015: Journal of Clinical Microbiology
Sadia Khan, Anil Kumar, Vivek Vinod, Vivek Prabhakar, Malini Eapen, Jacob Thomas, Kavitha Dinesh, Shamsul Karim
Chromoblastomycosis is a chronic subcutaneous mycosis commonly caused by Fonsecaea, Phialophora, and Cladophialophora spp. Out of these, Fonsecaea pedrosoi is the most common etiological agent, implicated in 70%-90% of the cases reported worldwide. The histopathological diagnosis of chromoblastomycosis is based on visualization of medlar or sclerotic bodies in the tissue. These sclerotic bodies divide by planar division. Rarely, budding is seen in these sclerotic bodies. As this entity can be confused with phaeohyphomycosis, it is important to be aware of such a presentation also...
March 2015: Journal of Infection in Developing Countries
Katja Sterflinger, Ksenija Lopandic, Barbara Blasi, Caroline Poynter, Sybren de Hoog, Hakim Tafer
The fungal genus Cladophialophora comprises many species which cause severe and even fatal infections in humans as well as environmental strains able to degrade polyaromatic hydrocarbons. The draft genome of Cladophialophora immunda presented here is the first whole-genome sequence within this important genus.
2015: Genome Announcements
Anna Brischetto, Sarah Kidd, Rob Baird
We describe the first case of possible pulmonary chromoblastomycosis in the absence of any identified cutaneous lesions in a relatively immunosuppressed man. The causative organism was Cladophialophora arxii, which is a rare pathogen that has only been described as causing human disease two times previously.
April 2015: American Journal of Tropical Medicine and Hygiene
Anthony B Zambelli, Catherine A Griffiths
This report describes a 6-year-old neutered male feline immunodeficiency-positive cat with repeated abdominal and thoracic effusions. The cat was diagnosed with and treated for lymphosarcoma but remission was short-lived and, on re-evaluation, a fungal peritoneal exudate was noted. Cytology of the organisms is described and the culture elucidated Cladosporium carrionii, an important cause of chromoblastomycosis. Treatment with itraconazole was unsuccessful in this case.
April 2015: Journal of Feline Medicine and Surgery
Anas Mansour, Kim Jordan
Cladophialophora bantiana, a dematiaceous fungus from the family Phaeohyphomycetes, is highly neurotropic and primarily reported as a rare cause of brain abscess. Pulmonary infection and disease outside the central nervous system is extremely rare, particularly in immunocompetent patients. We report an unusual case of disseminated cladosporiosis in a young man with a new diagnosis of prediabetes but no other identifiable risk factors for disease. Fungal cultures were positive for C. bantiana from brain abscess aspiration, vertebral bone cultures and subcarinal lymph node biopsy...
November 14, 2014: BMJ Case Reports
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