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Francisca Hernández-Hernández, Jaime Vargas-Arzola, Oliver Pedro Ríos-Cruz, Erika Córdova-Martínez, Patricia Manzano-Gayosso, Aristeo Segura-Salvador
Chromoblastomycosis is a chronic infection, caused by pigmented fungi affecting skin and subcutaneous tissues characterized by verrucous nodules or plaques. Fonsecaea pedrosoi and Cladophialophora carrionii are the prevalent agents in the endemic areas. Phoma is an uncommon agent of human infection and involved mainly with phaeohyphomycosis cases. The case of a patient with a history of laceration in foot followed by verrucous aspect and scaly lesions, which had evolved for 27 years is presented. On physical examination disease was clinically compatible with chromoblastomycosis and the microscopic examination of scales showed fumagoid cells...
October 7, 2016: Enfermedades Infecciosas y Microbiología Clínica
Fatih Mehmet Adibelli, Nilgun Karabicak, Ali Akal, Tugba Goncu, Omer Faruk Yilmaz, Mehmet Bayraktar
Conjunctival ulceration accompanied with secretion and pain was observed in a 30-year-old male, 3 days after a perforating corneal trauma. Cultures of conjunctival ulcer samples grew Fonsecaea pedrosoi, a major causative agent of chromoblastomycosis that is typically transmitted during trauma. The conjunctival ulcer was successfully treated with amphotericin B, itraconazole, and fluconazole. This case report summarizes the diagnosis and treatment of a conjunctival ulcer due to F. pedrosoi, which is a rare complication of contaminated ocular trauma...
July 2016: Arquivos Brasileiros de Oftalmologia
X Q Li, B L Guo, W Y Cai, J M Zhang, H Q Huang, P Zhan, L Y Xi, V A Vicente, B Stielow, J F Sun, G S de Hoog
Melanisation has been considered to be an important virulence factor of Fonsecaea monophora. However, the biosynthetic mechanisms of melanisation remain unknown. We therefore used next generation sequencing technology to investigate the transcriptome and digital gene expression data, which are valuable resources to better understand the molecular and biological mechanisms regulating melanisation in F. monophora. We performed de novo transcriptome assembly and digital gene expression (DGE) profiling analyses of parent (CBS 122845) and albino (CBS 125194) strains using the Illumina RNA-seq system...
2016: Studies in Mycology
Flávia F Costa, Sybren de Hoog, Roberto T Raittz, Vinicius A Weiss, Aniele C R Leão, Amanda Bombassaro, Jiufeng Sun, Leandro F Moreno, Emanuel M Souza, Fabio O Pedrosa, Maria Berenice R Steffens, Valter Baura, Michele Z Tadra-Sfeir, Eduardo Balsanelli, M Javad Najafzadeh, Renata R Gomes, Maria S Felipe, Marcus Teixeira, Germana D Santos, Liyan Xi, Mauro Antônio Alves de Castro, Vânia A Vicente
On the basis of multilocus phylogenetic data, Fonsecaea nubica was described in 2010 as a molecular sibling of F. monophora, an established agent of the human skin disease chomoblastomycosis in tropical zones. Genome analysis of these pathogens is mandatory to identify genes involved in the interaction with host and virulence.
2016: Genome Announcements
Amanda Bombassaro, Sybren de Hoog, Vinicius A Weiss, Emanuel M Souza, Aniele C R Leão, Flávia F Costa, Valter Baura, Michele Z Tadra-Sfeir, Eduardo Balsanelli, Leandro F Moreno, Roberto T Raittz, Maria Berenice R Steffens, Fabio O Pedrosa, Jiufeng Sun, Liyan Xi, Anamélia L Bocca, Maria S Felipe, Marcus Teixeira, Germana D Santos, Flávio Q Telles Filho, Conceição M P S Azevedo, Renata R Gomes, Vânia A Vicente
The black yeast Fonsecaea monophora is one of the main etiologic agents of chromoblastomycosis in humans. Its pathogenicity profile is more invasive than that of related Fonsecaea species, causing brain infection in addition to (sub)cutaneous infections.
2016: Genome Announcements
Prabhava Bagla, Michael Loeffelholz, Lucas S Blanton
Fungal infections are infrequent causes of brain abscesses. Fonsecaea monophora is a dematiaceous fungus that appears to be neurotropic. We report a case of Fonsecaea monophora infection in a patient with acquired immunodeficiency syndrome, and review previous reports of brain abscesses by this organism.
June 2016: Medical Mycology Case Reports
Dongmei Shi, Wei Zhang, Guixia Lu, G Sybren de Hoog, Guanzhao Liang, Huan Mei, Hailin Zheng, Yongnian Shen, Weida Liu
Chromoblastomycosis is caused by dematiaceous fungi. It develops after inoculation of the organism into the skin. We report a case of chromoblastomycosis in a pulmonary tuberculosis patient without known history of trauma. The lesions were initially diagnosed as sporotrichosis and skin tuberculosis. Histopathology of scales and skin biopsy specimen revealed sclerotic bodies, the hallmark of chromoblastomycosis. The causative organism was identified as Fonsecaea monophora by rDNA ITS sequencing. The lesions recovered markedly after two month treatment with oral terbinafine 250 mg daily according to drug sensitive test in vitro in combination with local thermotherapy...
March 2016: Medical Mycology Case Reports
Yingdan Chen, Songchao Yin, Meirong Li, Rongzhang Chen, Ling Wei, Han Ma, Shuwen Deng, Gert Sybren de Hoog, Wei Lai, Chun Lu, Peiying Feng
A first auricular case of chromoblastomycosis due to Fonsecaea nubica is reported in a 42-year-old Chinese male. He presented a slightly verrucous, erythematous plaque on his right auricle which had gradually extended over a 10-year period, and the patient reported a history of dog flea sting before onset of the lesions. Diagnosis was based on histopathological and mycological examination of clinical samples, which revealed muriform cells. Identification of the aetiological agent was assessed by morphological characteristics and confirmed at species level by sequencing of the rDNA internal transcribed spacer (ITS)...
October 2016: Mycoses
C Nayyar, N Gulati, B L Sherwal
Dematiaceous fungi are the etiological agents of phaeohyphomycosis and are now increasingly being recognized for causing disease in humans. A high level of suspicion and routine fungal cultures are required to identify these cases. There is no consensus regarding their management. Here, an unusual presentation of phaeohyphomycosis (secondary to Fonsecaea pedrosoi) presenting as a disseminated infection in a case of nephrotic syndrome is described.
May 2016: Indian Journal of Nephrology
Tsuyoshi Ushigami, Kazushi Anzawa, Takashi Mochizuki
Fonsecaea pedrosoi sensu lato is a major causative agent of dematiaceous fungal infection in Japan. Recent sequence analysis of the internal transcribed spacer (ITS) regions of the ribosomal RNA gene has shown that this species can be separated into three species: F. pedrosoi sensu stricto, F. monophora and F. nubica. The cell walls of dematiaceous fungi including the genus Fonsecaea contain melanin, which is important for their virulence. Polyketide synthase (PKS1) is an enzyme required for melanin synthesis...
May 10, 2016: Journal of Dermatology
Marilia M Ogawa, Marcella P Peternelli, Milvia M S S Enokihara, Angela S Nishikaku, Sarah Santos Gonçalves, Jane Tomimori
Chromoblastomycosis and phaeohyphomycosis are melanized fungal infections, which affect skin and subcutaneous tissues in immunocompetent and immunosuppressed patients, as solid-organ transplant recipients, respectively. In this present study, we report six cases of melanized fungal infection in kidney transplant recipients. In five cases, culture of tissue specimens identified two cases of Exophiala spp. and three cases of Fonsecaea spp. Molecular identification was performed in three cases based on sequencing of rDNA (ITS region) that revealed the following agents: Exophiala xenobiotica, Exophiala bergeri and Fonsecaea monophora...
June 2016: Mycopathologia
Hirak Jyoti Raj, Banashree Majumdar, Atul Jain, Prasanta Kumar Maiti, Gobinda Chatterjee
INTRODUCTION: Verrucous plaques mimicking chromoblastomycosis are frequently seen in dermatology outpatient departments (OPD). However, no scientific evaluation has been carried out till date from eastern India. So this present endeavour is aimed at a thorough study of those cases to readdress the challenges in diagnosis and management in chromoblastomycosis from this part of the country. AIM: The study is to observe the incidence of proved chromoblastomycosis cases from clinically mimicking conditions and to note therapeutic prospects by use of different antifungal agents...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
Brun Sophie, Zumelzu Coralie, Hoanganh Mai Ba, Levy Annie, Garcia-Hermoso Dea, Laroche Liliane, Izri Arezki
Chromoblastomycosis is a rare and chronic cutaneous and subcutaneous infection caused by black fungi and mostly reported in tropical and subtropical areas. Here we report the first case of chromoblastomycosis from Bangladesh. Molecular biology permitted to identify Fonsecaea nubica, and the patient responded well to antifungal treatment alone.
December 2015: Medical Mycology Case Reports
Marcel Wüthrich, Huafeng Wang, Mengyi Li, Tassanee Lerksuthirat, Sarah E Hardison, Gordon D Brown, Bruce Klein
Chromoblastomycosis is a chronic skin infection caused by the pigmented saprophytic mould Fonsecaea pedrosoi. Chronicity of infection can be broken by a coordinated innate recognition of the spores by pattern recognition receptors. While Mincle signaling via the Syk/Card9 pathway is required for fungal recognition by host cells, it is not sufficient for host control. Exogenously applied TLR agonists are necessary to promote the induction of proinflammatory cytokines and clearance of infection in vivo. Here, we investigated whether costimulation by TLR agonists fosters the development of adaptive immune responses, by examining the development of fungus-specific T cells...
September 2015: European Journal of Immunology
Conceição M P S de Azevedo, Renata R Gomes, Vania A Vicente, Daniel W C L Santos, Sirlei G Marques, Mariana M F do Nascimento, Caroline E W Andrade, Raimunda R Silva, Flávio Queiroz-Telles, G Sybren de Hoog
We report a fatal case of a chromoblastomycosis-like infection caused by a novel species of Fonsecaea in a 52-year-old immunocompetent Caucasian male from an area of chromoblastomycosis endemicity in Brazil. The patient had a 30-year history of slowly evolving, verrucous lesions on the right upper arm which gradually affected the entire arm, the left hemifacial area, and the nose. Subsequent dissemination to the brain was observed, which led to death of the patient. The internal transcribed spacer (ITS) and partial large subunit (LSU), BT2, and CDC42 genes of the isolates recovered from skin and brain were sequenced, confirming the novelty of the species...
August 2015: Journal of Clinical Microbiology
Winai Chaidaroon, Napaporn Tananuvat, Pimploy Chavengsaksongkram, Nongnuch Vanittanakom
PURPOSE: To report 2 unusual cases of fungal keratitis due to Fonsecaea pedrosoi. METHODS: Two patients were diagnosed with Fonsecaea pedrosoi keratitis. Their files were reviewed for predisposing factors, clinical characteristics, microbiological study, treatment, and outcome. RESULTS: Two consecutive patients presented with brownish pigmented corneal ulcers in their eyes after sustaining eye trauma from vegetative matter. In both cases, corneal scrapings were collected for microscopic examination and culture...
January 2015: Case Reports in Ophthalmology
Mina Zarei, Samantha Schneider, Alexandra Villasante, Gabriel Villada, Tejas Patel, Shasa Hu, Paolo Romanelli
Chromoblastomycosis (CBM) is a slowly progressive cutaneous and subcutaneous mycosis mostly seen in tropical and subtropical areas and Fonsecaea pedrosoi is the most common cause. The authors describe the case of a diabetic Haitian woman, presenting with a chronic verrucous plaque without any history of trauma. Her histopathologic results showed epidermal hyperplasia and sclerotic bodies, which are diagnostic for CBM. Her therapy began with itraconazole 200 mg tablets twice a day. The unique feature of this patient is the coincidence of diabetes and CBM...
September 2015: American Journal of Dermatopathology
(no author information available yet)
No abstract text is available yet for this article.
2015: PloS One
Sadia Khan, Anil Kumar, Vivek Vinod, Vivek Prabhakar, Malini Eapen, Jacob Thomas, Kavitha Dinesh, Shamsul Karim
Chromoblastomycosis is a chronic subcutaneous mycosis commonly caused by Fonsecaea, Phialophora, and Cladophialophora spp. Out of these, Fonsecaea pedrosoi is the most common etiological agent, implicated in 70%-90% of the cases reported worldwide. The histopathological diagnosis of chromoblastomycosis is based on visualization of medlar or sclerotic bodies in the tissue. These sclerotic bodies divide by planar division. Rarely, budding is seen in these sclerotic bodies. As this entity can be confused with phaeohyphomycosis, it is important to be aware of such a presentation also...
March 2015: Journal of Infection in Developing Countries
O Carolina Rojas, Rafael B R León-Cachón, Antonio Alí Pérez-Maya, Marcelino Aguirre-Garza, María G Moreno-Treviño, Gloria M González
Chromoblastomycosis is a chronic granulomatous disease caused frequently by fungi of the Fonsecaea genus. The objective of this study was the phenotypic and molecular identification of F. pedrosoi strains isolated from chromoblastomycosis patients in Mexico and Venezuela. Ten strains were included in this study. For phenotypic identification, we used macroscopic and microscopic morphologies, carbohydrate assimilation test, urea hydrolysis, cixcloheximide tolerance, proteolitic activity and the thermotolerance test...
May 2015: Mycoses
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