keyword
https://read.qxmd.com/read/38537239/efficacy-of-diltiazem-2-rectal-gel-in-the-treatment-of-chronic-anal-fissure-a-retrospective-observational-study
#1
JOURNAL ARTICLE
Gabriel Martínez-Orea, Francisco J Rodríguez-Lucena, Celia García-González, Nieves Cano-Cuenca, Ana Candela-Fajardo, Rodrigo Bonilla-Peñarrubia
OBJECTIVE: The aim of this study is to describe the effectiveness and safety of a magistral formulation of diltiazem 2% rectal gel as a treatment for chronic anal fissure. MATERIAL AND METHODS: A retrospective observational study of all patients that began treatment with diltiazem 2% gel during 2019. The primary endpoint of the study was anal fissure healing. We also looked for differences in effectiveness between those initiating treatment and those who had been previously treated, long-term effectiveness through a 2-year follow-up and frequency of adverse effects...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537237/effects-of-different-surgical-treatments-on-pain-disability-anxiety-and-quality-of-life-in-lumbar-disc-herniation
#2
JOURNAL ARTICLE
Aydin S Apaydin, Bülent Bozyiğit, Zuhal Koç-Apaydin, Musa Güneş, Metehan Yana
OBJECTIVE: This study aims to compare the effects of microscopic microdiscectomy and microendoscopic discectomy on pain, disability, fear of falling, kinesiophobia, anxiety, quality of life in patients with lumbar disc herniation (LDH). METHODS: A total of 90 patients who underwent microscopic microdiscectomy (n = 40) and microendoscopic discectomy (n = 50) for LDH were included in this study. The patients' pain, disability, fear of falling, kinesiophobia, anxiety, and quality of life were evaluated before the surgery, in the early postoperative period and three months after...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537234/clinical-and-urodynamics-outcomes-in-pediatric-primary-bladder-diverticula-a-comparative-study
#3
JOURNAL ARTICLE
Birgül Karaaslan, Mehmet O Kuzdan
OBJECTIVE: This study aimed to compare the effects of bladder diverticula smaller than 30 (SD) mm and larger than 30 mm (LD) on bladder functions and urodynamics. MATERIALS AND METHODS: Our retrospective analysis involved a cohort of 40 pediatric patients diagnosed with primary bladder diverticula. RESULTS: The predicted mean bladder capacity (MBC) was 197.7 ± 95.8 mL, whereas the observed MBC was lower at an average of 170.1 ± 79...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537233/risk-factors-for-readmission-after-a-cholecystectomy-a-case-control-study
#4
JOURNAL ARTICLE
Daniel Garcia, Antonia Pastore, Javier Rodriguez, Fernando Crovari, Jaime Cerda, Patricia Rebolledo, Pablo Achurra, Eduardo Viñuela, Jorge Martinez, Martin Dib, Eduardo Briceño
OBJECTIVE: The aim of this study was to assess the risk factors associated with 30-day hospital readmissions after a cholecystectomy. METHODS: We conducted a case-control study, with data obtained from UC-Christus from Santiago, Chile. All patients who underwent a cholecystectomy between January 2015 and December 2019 were included in the study. We identified all patients readmitted after a cholecystectomy and compared them with a randomized control group. Univariate and multivariate analyses were conducted to identify risk factors...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537226/can-platelet-activation-markers-predict-preeclampsia-and-or-its-severity
#5
JOURNAL ARTICLE
Tuğçe Arslanoğlu, Kübra Kurt-Bilirer, Nihal Çallıoğlu, Selvi Aydın-Şenel, Işıl Turan-Bakırcı, İklil N Koç-Erol, Emre Kar, Zeliha Bayram, Ibrahim Polat
OBJECTIVE: This study aimed to evaluate the value of platelet activation markers in predicting preeclampsia and its severity. Preeclampsia is a serious pregnancy complication that affects 3-5% of pregnancies and can lead to significant morbidity and mortality for both the mother and the fetus. METHODS: The study included 99 patients diagnosed with preeclampsia and 60 healthy pregnant women as a control group. Platelet activation markers such as mean platelet volume (MPV), platelet distribution width (PDW), platelet count, and plateletcrit were evaluated along with other clinical parameters...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537201/prospective-evaluation-of-serum-free-thiols-in-inflammatory-bowel-disease-a-candidate-to-replace-c-reactive-protein-for-disease-activity-assessment
#6
JOURNAL ARTICLE
Anuj Bohra, Nicholas Batt, Krishneel Dutt, Pavel Sluka, Olga Niewiadomski, Abhinav Vasudevan, Daniel R Van Langenberg
BACKGROUND: Serum free thiols (SFTs) reflecting oxidative stress appear to correlate with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of SFTs concentrations vs endoscopic and histological activity, compare SFTs with established biomarkers, and identify clinical and laboratory parameters independently associated with SFT levels in IBD patients. METHODS: Patients with confirmed IBD undergoing routine ileocolonoscopy for activity assessment were prospectively recruited, with serum samples obtained concurrently for SFTs and routine bloods, plus fecal calprotectin and immunochemical tests were collected ±30 days from ileocolonoscopy...
March 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38537188/multimodal-ultrasonography-evaluation-in-thyroid-nodule-characterization-what-is-the-ideal-algorithm
#7
JOURNAL ARTICLE
Başak Erdemli Gürsel, Barış Çağlar, Rıfat Özpar, Özlem Saraydaroğlu, Gökhan Gökalp, Naile Bolca Topal
AIMS: The aim of this study is to investigate the diagnostic performances of Ultrasonography (US), Shear-wave Elastography (SWE), and Superb Microvascular Imaging (SMI) findings in the diagnosis of malignant thyroid nodules (MTNs) and to determine the US algorithm with the best diagnostic performance. MATERIAL AND METHODS: Eighty-one nodules in 77 patients who had underwent multimodal US with biopsy results, were evaluated. Echogenicity, nodule components, contours, presence and type of calcification, and size were analyzed with US...
March 27, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537186/can-the-width-of-lower-tongue-base-preoperative-sonography-measurements-predict-hypoxemia-during-esophagogastroduodenoscopy-under-sedation-in-asa-i-ii-patients
#8
JOURNAL ARTICLE
Hao Wu, Min Xia, Xu Chen, Sheng Wang, Wei Zhang
The most common complication during esophagogastroduodenoscopy (EGD) under sedation is hypoxemia. There is a scarcity of indicators to predict the risk of hypoxemia during EGD under sedation accurately. The width of the lower tongue base measured by ultrasound (US) is considered to be a significant predictor of the presence and severity of obstructive sleepapnea syndrome (OSAS), which develops hypoxemia by a similar mechanism to EGD under sedation. This study aimed to observe its ability to predict hypoxemia during EGD under sedation...
January 30, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537182/diagnostic-and-prognostic-efficacy-of-optic-nerve-sheath-diameter-in-patients-with-dysnatremia
#9
JOURNAL ARTICLE
Berika Kavaz Kuru, Ahmet Baydın, Metin Ocak, İskender Aksoy
AIM: This study aimed to investigate the diagnostic and prognostic value of optic nerve sheath diameter (ONSD) measurement in patients with dysnatremia. MATERIAL AND METHODS: This prospective clinical study included patients aged ≥18 years who were diagnosed with dysnatremia on admission to the emergency department. RESULTS: The present study included 65 patients (35 with hypernatremia [hypernatremia group] and 30 with hyponatremia [hyponatremia group]) and 14 healthy volunteers (control group)...
February 13, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537180/perfluorobutane-sonazoid-contrast-enhanced-ultrasound-to-diagnose-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#10
REVIEW
Yujia Chen, Wenjun Zhu, Yunyun Yi, Huali Cao, Fan Chen, Qinling Zhu
AIM: This meta-analysis aimed to assess the precision of Sonazoid contrast-enhanced ultrasound (CEUS) to distinguish hepatocellular carcinoma (HCC) from focal liver lesions (FLLs). MATERIAL AND METHODS: The Cochrane Library, Embase, PubMed, and Web of Science databases were systematically searched and checked for studies using Sonazoid CEUS to characterize HCC. A comprehensive meta-analysis was conducted, involving data pooling, subgroup analyses, meta-regression, and investigation of publication bias...
February 25, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537176/toward-development-of-a-novel-proprioceptive-trail-making-test-comparing-healthy-dancers-and-non-dancers
#11
JOURNAL ARTICLE
Madison R Card, Anthony J Ryals
There is a pressing need for ecologically valid versions of traditional neuropsychological tests indexing executive function (EF), such as the Trail-Making Task (TMT), that incorporate movement and bodily awareness in healthy participants with varying abilities. We designed a proprioceptive version of the TMT (pTMT) that involved coordinated gross motor movement and proprioceptive awareness to investigate whether this measure of visual attention, task switching, and working memory positively correlated with a computerized version of the TMT (the dTMT)...
March 27, 2024: Perceptual and Motor Skills
https://read.qxmd.com/read/38537154/the-future-of-liver-transplantation
#12
JOURNAL ARTICLE
Sandy Feng, Garrett R Roll, Foad J Rouhani, Alberto Sanchez Fueyo
Over the last 50 years, liver transplantation has evolved into a procedure routinely performed in many countries worldwide. Those able to access this therapy frequently experience a miraculous risk-benefit ratio since, particularly if they face imminently life threatening disease. Over the decades, the success of liver transplantation, with dramatic improvements in early post-transplant survival, has aggressively driven demand. However, in spite of the emergence of living donors to augment deceased donors as a source of organs, supply has lagged far behind demand...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537151/development-and-validation-of-a-machine-learning-prognostic-model-of-m5c-related-immune-genes-in-lung-adenocarcinoma
#13
JOURNAL ARTICLE
Xiong Cao, Yuxing Ji, Jiajia Li, Zhikang Liu, Chang Chen
BACKGROUND: The aim of this retrospective research was to develop an immune-related genes significantly associated with m5C methylation methylation (m5C-IRGs)-related signature associated with lung adenocarainoma (LUAD). METHODS: We introduced transcriptome data to screen out m5C-IRGs in The Cancer Genome Atlas (TCGA)-LUAD dataset. Subsequently, the m5C-IRGs associated with survival were certificated by Kaplan Meier (K-M) analysis. The univariate Cox, least absolute shrinkage and selection operator (LASSO) regression, and xgboost...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38537134/nk-cell-elicited-gasdermin-d-dependent-hepatocyte-pyroptosis-induces-neutrophil-extracellular-traps-that-facilitates-hbv-related-acute-on-chronic-liver-failure
#14
JOURNAL ARTICLE
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo
BACKGROUND AIMS: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537096/compliance-with-a-who-guideline-for-cardiovascular-disease-prevention-a-population-based-cross-sectional-study-in-argentina
#15
JOURNAL ARTICLE
Pablo Gulayin, Laura Gutierrez, Fernando Lanas, Nora Mores, Jacqueline Ponzo, Matías Calandrelli, Rosana Poggio, Vilma Irazola
INTRODUCTION: Current recommendations for cardiovascular disease (CVD) prevention are guided CVD risk classification. This study aims to analyze the level of compliance with pharmacological and non-pharmacological recommendations outlined in the World Health Organization (WHO) CVD prevention clinical practice guideline within the general population of two cities in Argentina. METHODS: We analyzed the compliance with preventive recommendations from the WHO 2007 Guidelines for Management of Cardiovascular Risk in two cities of Argentina participating in the CESCAS population-based study in the Southern Cone of Latin America...
March 27, 2024: Revista de la Facultad de Ciencias Médicas
https://read.qxmd.com/read/38537077/nomogram-for-predicting-difficult-total-laparoscopic-hysterectomy-a-multi-institutional-retrospective-model-development-and-validation-study
#16
JOURNAL ARTICLE
Yin Chen, Jiahong Jiang, Min He, Kuiyan Zhong, Shuai Tang, Li Deng, Yanzhou Wang
BACKGROUND: Total laparoscopic hysterectomy (TLH) is the most commonly performed gynecological surgery. However, the difficulty of the operation varies depending on the patient and surgeon. Subsequently, patient's outcomes and surgical efficiency are affected. We aimed to develop and validate a pre-operative nomogram to predict the operative difficulty in patients undergoing TLH. METHODS: This retrospective study included 663 patients with TLH from XXX Hospital and 102 patients from YYY Hospital in Chongqing, China...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537072/clinicopathologic-characteristics-and-outcomes-of-prostate-cancer-incidentally-discovered-at-the-time-of-radical-cystoprostatectomy-a-population-based-cohort-study
#17
JOURNAL ARTICLE
Kan Wu, Xu Liu, Yaxiong Tang, Xianding Wang, Xiang Li
OBJECTIVE: This study aimed to comprehensively analyze the clinical characteristics and prognosis of patients with concomitant bladder cancer (BCa) and prostate cancer (PCa) using a large population-based database. METHODS: Within the Surveillance, Epidemiology, and End Results (SEER) database (2000-2019), we identified patient with concomitant PCa at the time of radical cystoprostatectomy (RCP). Logistic regression and propensity score matching (PSM) analyses were employed to identify risk factors and mitigate confounders, respectively...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537071/metabolic-tumor-burden-as-a-prognostic-indicator-after-neoadjuvant-chemotherapy-in-pancreatic-cancer
#18
JOURNAL ARTICLE
Woohyung Lee, Minyoung Oh, Jae Seung Kim, Minkyu Sung, Kwangpyo Hong, Bong Jun Kwak, Yejong Park, Eunsung Jun, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Changhoon Yoo, Kyu-Pyo Kim, Inkeun Park, Jae Ho Jeong, Heung-Moon Chang, Baek-Yeol Ryoo, Jung Bok Lee, Song Cheol Kim
BACKGROUND: There is no standardized assessment for evaluating response although neoadjuvant chemotherapy (NAT) is widely accepted for borderline resectable or locally advanced pancreatic cancer (BRPC or LAPC). This study was aimed to evaluate NAT response using positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG-PET/CT) parameters alongside carbohydrate antigen (CA) 19-9 levels. METHODS: Patients who underwent surgery after NAT for BRPC and LAPC between 2017 and 2021 were identified...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537063/impella-as-bridge-to-durable-left-ventricular-assist-device-in-acute-myocardial-infarction-cardiogenic-shock-patients
#19
JOURNAL ARTICLE
Silvia Ajello, Marina Pieri, Sara Dormio, Luca Baldetti, Savino Altizio, Filippo Consolo, Pasquale Nardelli, Alessandro Ortalda, Anna Mara Scandroglio
Implantation of durable left ventricular assist device (LVAD) in cardiogenic shock (CS) patients after acute myocardial infarction (AMI) poses specific challenges (small left ventricular size, acute infarct area, need for antithrombotic therapy, status Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) 1 with impaired organ function and derangements in coagulation and inflammatory parameters) which may affect outcomes. We reviewed data of all AMI-CS patients who were implanted LVAD after Impella support at a referral center with the aim to analyze feasibility, timing, and outcomes of durable LVAD implantation after tMCS with Impella due to AMI-CS...
March 28, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38537050/deep-anterior-lamellar-keratoplasty-and-penetrating-keratoplasty-in-macular-corneal-dystrophy-comparison-of-visual-and-topographic-outcomes-and-complications
#20
JOURNAL ARTICLE
Ayşe Tüfekçi Balıkçı, Ayşe Burcu, Züleyha Yalnız Akkaya, Evin Singar, Selma Uzman
PURPOSES: This study aims to assess and compare the postoperative visual and topographic outcomes, complications, and graft survival rates following deep anterior lamellar keratoplasty and penetrating keratoplasty in patients with macular corneal dystrophy. METHODS: In this study we enrolled 59 patients (23 male; and 36 female) with macular corneal dystrophy comprising 81 eyes. Out of these, 64 eyes underwent penetrating keratoplasty, while 17 eyes underwent deep anterior lamellar keratoplasty...
2024: Arquivos Brasileiros de Oftalmologia
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