Read by QxMD icon Read

Alvan Feinstein

Giovanni A Fava
John Ioannidis has provided a lucid account, in the form of a report to David Sackett, of how evidence-based medicine (EBM) was hijacked to serve vested interests: major randomized controlled trials are largely done by and for the benefit of the industry; meta-analyses and guidelines are flooded with conflicts of interest; national and federal research funds are unable to address basic clinical questions. Nonetheless, EBM would remain a worthwhile goal. In this paper, in the form of a report to Alvan Feinstein, it is argued that current developments were largely predictable...
April 2017: Journal of Clinical Epidemiology
(no author information available yet)
Medicine is built up of single cases. Individual patients-single cases-are the essence of what medicine deals with. Every patient is important, and every case can be a lesson. Clinician, researcher, and epidemiologist Alvan Feinstein said, "In caring for patients, clinicians constantly perform experiments. During a single week of active practice, a busy clinician conducts more experiments than most of his laboratory colleagues do in a year."(1) Medicine stretches between the intertwined poles of being developed in the laboratories of the pharmaceutical industry and in the clinical practice of the "clinical champions"-the innovative clinician, therapist, nurse, or midwife...
March 2012: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
Elizabeth Heaton, Michelle M Levender, Steven R Feldman
BACKGROUND: Poor adherence to treatment is a significant problem throughout medicine and particularly in the treatment of dermatologic conditions with topical medications, which present unique barriers to adherence. PURPOSE: We reviewed the literature to assess whether timing of office visits can be used to improve adherence. METHODS: Studies examining adherence and office visits were identified using two search engines. PubMed was searched using the terms "medication adherence" OR "medication compliance" AND "visits...
April 2013: Journal of Dermatological Treatment
Rodolfo Rivas-Ruiz, Juan O Talavera
In the process of responding to questions generated during medical care, the number of articles appearing in the search is so vast that a strategy must be considered. This article describes the process to find and select the information to help us respond the needs of our patients. The judgment of the quality and relevance of the answer depends on each reader. Initially you have to look in places where there is medical arbitration for publications, reasons why we recommend PubMed. Start the search once the acronym PICO breakdown, where P is for patients, I intervention, C comparator and O outcome or result; these words are used as MeSH (Medical Subject Headings) and are linked with Boolean terms (and, or, and not)...
January 2012: Revista Médica del Instituto Mexicano del Seguro Social
G A Fava, E Tomba, N Sonino
'Clinimetrics' is the term introduced by Alvan R. Feinstein in the early 1980s to indicate a domain concerned with indexes, rating scales and other expressions that are used to describe or measure symptoms, physical signs and other clinical phenomena. Clinimetrics has a set of rules that govern the structure of indexes, the choice of component variables, the evaluation of consistency, validity and responsiveness. This review illustrates how clinimetrics may help expanding the narrow range of information that is currently used in clinical science...
January 2012: International Journal of Clinical Practice
Soriano-Sánchez José-Antonio, Marcos Baabor-Aqueveque, Francisco Silva-Morales
The main goal of improving pain and neurological deficit in the practice of spine surgery is changing for a more ambitious goal, namely to improve the overall quality of life and the future of patients through three major actions (1) preserving the vertebral anatomical structures; (2) preserving the paravertebral anatomical structures; and (3) preserving the functionality of the segment. Thus, three new concepts have emerged (a) minimal surgery; (b) minimal access surgery; and (c) motion preservation surgery...
2011: Acta Neurochirurgica. Supplement
Maria Pia Sormani
The 'Will Rogers phenomenon' is an apparent epidemiological paradox named after a remark made by the humorist Will Rogers about migration during the American economic depression of the 1930's: "When the Okies left Oklahoma and moved to California, they raised the average intelligence level in both states." In 1985, Alvan Feinstein proposed the name 'Will Rogers Phenomenon' to describe the 'stage migration' he observed in patients with cancer. Changes in the criteria for assigning patients to the various stages of a disease can produce spurious improvements in stage-specific prognosis, even though the outcome of individual patients has not changed...
December 2009: Journal of the Neurological Sciences
Robert M Jacobson, Gregory A Poland
Negative studies of vaccine adverse events occur with some frequency in the published literature. They serve important roles in fending off claims posed by the anti-vaccine movement and in reinforcing public health efforts to prevent diseases. Still, negative studies frequently suffer from concerns of adequate sample size. The double-significance Neyman-Pearson formula for sample size calculation that is now in vogue results in immense sample sizes that can lead to illogical interpretations. The late Professor Alvan R...
March 18, 2005: Vaccine
Robert M Jacobson, Gregory A Poland
The development of combination vaccines as well as the improved manufacture of vaccines have resulted in the need for clinical studies seeking equivalence or non-inferiority as investigators seek to demonstrate that combination vaccines achieve the same levels of efficacy, immunogenicity, and safety as their individual counterparts. Given the nature of the statistical analysis, studies of equivalence require particular attention to sample size. The current double-significance method of Neyman-Pearson attempts to address problems with equivalence testing, but it leads to very large sample sizes and illogical results...
March 18, 2005: Vaccine
Andrew A Nierenberg, Nicoletta Sonino
No abstract text is available yet for this article.
May 2004: Psychotherapy and Psychosomatics
Gail Vitagliano, Jeptha P Curtis, John Concato, Alvan R Feinstein, Martha J Radford, Harlan M Krumholz
OBJECTIVES: To examine whether physical and cognitive impairments explain low use of beta-blockers in elderly patients and whether functionally impaired older adults have improved survival if a beta-blocker is prescribed at hospital discharge. DESIGN: Cross-sectional and retrospective cohort study. SETTING: Acute care hospitals in the United States. PARTICIPANTS: National cohort of 45,370 elderly acute myocardial infarction survivors, with no chart-documented contraindications to beta-blocker treatment...
April 2004: Journal of the American Geriatrics Society
Carmen Lara-Muñoz, Sergio Ponce De Leon, Alvan R Feinstein, Alicia Puente, Carolyn K Wells
BACKGROUND: An interest in measuring subjective phenomena such as pain, nausea, anxiety, etc. has led clinicians to develop three types of ratings: the visual analog scale (VAS); the verbal rating scale (VRS), and the numeric rating score (NRS). These ratings are regarded as global scales because they lack criteria to demarcate diverse dimensions or categories that comprise each scale. The purpose of this study was to evaluate validity and consistency of usage for these scales. Criterion for validity consisted of an experimentally controlled intensity for auditory stimuli...
January 2004: Archives of Medical Research
(no author information available yet)
No abstract text is available yet for this article.
May 2004: Psychotherapy and Psychosomatics
Sergio Ponce de Leon, Carmen Lara-Muñoz, Alvan R Feinstein, Carolyn K Wells
BACKGROUND: In a previous study of three types of global scales we found that verbal rating scales were particularly reliable for rating auditory stimuli. We now wanted to check the performance of the scales for rating experimentally controlled visual stimuli. METHODS: We used a prospective, experimentally controlled, clinimetric study, which was conducted at the Department of Psychiatry of the Autonomous University of Puebla Medical School in the state capital city of Puebla, Mexico...
March 2004: Archives of Medical Research
Alvan R Feinstein
No abstract text is available yet for this article.
2003: Perspectives in Biology and Medicine
John F Kurtzke
In his time with the Journal of Clinical Epidemiology and before, Dr. Alvan Feinstein espoused a philosophy of the study of epidemiology as a beneficial, valid science. Not only was Feinstein somewhat of a nonconformist in the field of epidemiology, he had a self-denigrating sense of humor as well. This sense of humor can be showcased by taking a look at one of the articles he approved for publication, which could be retitled as "The Finster Saga."
December 2002: Journal of Clinical Epidemiology
Alfredo Morabia
Alvan Feinstein was among the pioneers who perceived the need to apply epidemiologic principles and methods to clinical medicine. In his attempt to convert his peers to his own views, he was very liberal in criticizing the work of others. Epidemiologists still recall his 1988 article in Science entitled "Scientific Standards in Epidemiologic Studies of the Menace of Daily Life," in which he criticized observational epidemiology for its lack of scientific rigor. In this context, Feinstein's work has also been the center of controversies...
December 2002: Journal of Clinical Epidemiology
J André Knottnerus
The "iatrotropic stimulus" is a typical example of Alvan Feinstein's terminology and his clinical way of thinking about medical research. Feinstein specified "interiatric referral" as an additional important factor affecting "the likelihood that patients will appear at the particular setting in which research is being conducted." He emphasized these phenomena as highly relevant for clinical judgment, clinical research, and clinical epidemiology. This has stimulated the realization of original clinical research in international primary medical care...
December 2002: Journal of Clinical Epidemiology
Jan P Vandenbroucke
When thinking of a new study, the most important task is to define its goals and to choose a design to match those goals. Alvan Feinstein described how he went about consulting others on defining a research question in his book, "Clinical Epidemiology, the Architecture of Clinical Research." In this paper, the author reminisces about how he learned and tried to apply those principles.
December 2002: Journal of Clinical Epidemiology
Walter O Spitzer
Dr. Alvan R. Feinstein, late editor of the Journal of Clinical Epidemiology, is remembered by his fellow editor in this article. His role is highlighted as an innovative gatekeeper of clinical and epidemiological communications and as an effective secret mentor of his younger partner. The profile of his editorial practice is summarized as "six commandments" and the Golden Rule of pursuing attainable excellence.
December 2002: Journal of Clinical Epidemiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"