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https://www.readbyqxmd.com/read/29908443/novel-pyrimidinic-selenourea-induces-dna-damage-cell-cycle-arrest-and-apoptosis-in-human-breast-carcinoma
#1
Flavio A R Barbosa, Tâmila Siminski, Rômulo F S Canto, Gabriela M Almeida, Nádia S R S Mota, Fabiana Ourique, Rozangela Curi Pedrosa, Antonio Luiz Braga
Novel pyrimidinic selenoureas were synthesized and evaluated against tumour and normal cell lines. Among these, the compound named 3j initially showed relevant cytotoxicity and selectivity for tumour cells. Three analogues of 3j were designed and synthesized keeping in view the structural requirements of this compound. Almost all the tested compounds displayed considerable cytotoxicity. However, 8a, one of the 3j analogues, was shown to be highly selective and cytotoxic, especially for breast carcinoma cells (MCF-7) (IC50  = 3...
June 11, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908379/simultaneous-supratentorial-and-infratentorial-pilocytic-astrocytoma-in-an-adult-patient-with-concurrent-neurofibromatosis-type-1-and-hiv-infection
#2
Dalila Forte, Anabela Nabais, Carlos Pontinha, Manuela Mafra, Luís Mateus
BACKGROUND: Neurofibromatosis type 1 (NF1) is a tumour predisposing condition, being Pilocytic Astrocytomas (PA) a common benign central nervous system (CNS) tumour occurring in this setting. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in non-optic or hypothalamic locations. CLINICAL CASE: A 41 year-old female patient with neurofibromatosis type 1 and uncontrolled human immunodeficiency virus (HIV) type 1 infection presents with a first generalized seizure and associated headache and ataxia...
June 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29908099/pathogenesis-of-primordial-odontogenic-tumour-based-on-tumourigenesis-and-odontogenesis
#3
Toshinari Mikami, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Ikuko Ogawa, Vanesa Pereira-Prado, Naoki Fujiwara, Fabio Ramoa Pires, Roman Carlos, Takashi Takata, Yasunori Takeda
OBJECTIVE: Primordial odontogenic tumour (POT) is a rare benign mixed epithelial and mesenchymal odontogenic tumour. POT is composed of dental papilla-like tissue covered with cuboidal to columnar epithelium that resembles to inner and outer enamel epithelium of the enamel organ without dental hard tissue formation. The aim of this study was to examine pathogenesis of POT based on tumourigenesis and odontogenesis. SUBJECTS AND METHODS: Six cases of POT were submitted for study...
June 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29908096/il-6-tnf-%C3%AE-levels-and-periodontal-status-changes-during-the-menstrual-cycle
#4
Hacer Sahin Aydınyurt, Yusuf Ziya Yuncu, Yasin Tekin, Abdullah Seckin Ertugrul
OBJECTIVES: Sex steroid hormones are thought to affect periodontal tissues. A clear understanding of the effect of the menstrual cycle on oral tissues would be an important milestone in the timing of dental interventions in the future. The aim of this longitudinal, prospective study was to evaluate clinical periodontal parameters and levels of interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluid (GCF) during the menstrual cycle. METHODS: Forty-five patients were included in this study...
June 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29907679/the-tumour-suppressor-opcml-promotes-axl-inactivation-by-the-phosphatase-ptprg-in-ovarian-cancer
#5
Jane Antony, Elisa Zanini, Zoe Kelly, Tuan Zea Tan, Evdoxia Karali, Mohammad Alomary, Youngrock Jung, Katherine Nixon, Paula Cunnea, Christina Fotopoulou, Andrew Paterson, Sushmita Roy-Nawathe, Gordon B Mills, Ruby Yun-Ju Huang, Jean Paul Thiery, Hani Gabra, Chiara Recchi
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL directly interacts with OPCML, preferentially so when AXL is activated by its ligand Gas6. As a consequence, AXL accumulates in cholesterol-rich lipid domains, where OPCML resides. Here, phospho-AXL is brought in proximity to the lipid domain-restricted phosphatase PTPRG, which de-phosphorylates the RTK/ligand complex...
June 15, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29907623/unexpected-benefits-of-aging-for-favorable-responses-to-pd-1-blockade-in-melanoma
#6
Graham Pawelec
Immunosenescence might be expected to reduce the efficacy of checkpoint blockade, which depends on a functionally intact immune system. However, it seems that older melanoma patients may respond better to anti-PD1 treatment than younger patients, possibly due to their having fewer regulatory T-cells relative to CD8+ T-cells within tumour deposits.
June 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29907347/ophthalmological-changes-of-the-posterior-segment-in-patients-with-testicular-cancer-in-a-mixed-race-population-of-the-general-hospital-of-mexico
#7
D M Barba-Navarrete, D Moreno-Páramo, V E Corona-Montes, L E Tapia-López, E Montiel-Delgado
INTRODUCTION: The curing of a testicular tumour is currently feasible in more than 95% of patients, and in 80% of those with metastases. Until now, there has been no study or series of cases that describe the ocular changes of the posterior segment associated with testicular cancer. OBJECTIVE: To evaluate patients with a diagnosis of testicular cancer in order to determine the presence of changes in the posterior segment and the relationship to the stage. MATERIAL AND METHOD: An observational, cross-sectional, and descriptive study was conducted on 21 male patients (42 eyes) with a diagnosis of testicular cancer...
June 12, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29907185/density-measurement-of-demodex-canis-by-qpcr-and-analysis-of-serum-cytokine-levels-in-dogs-with-different-clinical-forms-of-demodicosis
#8
Naiani Domingos Gasparetto, Arleana do Bom Parto Ferreira Almeida, Luciano Nakazato, Eduardo Luzía França, Adenilda Cristina Honorio França, Danny Laura Gomes Fagundes, Juliano Bortolini, Valéria Régia Franco Sousa
OBJECTIVES: To quantify (by qPCR) the density of Demodex canis mites in the skin of dogs with demodicosis and in healthy dogs, as well as measuring the serum concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, and tumour necrosis factor-alfa (TNF-α). METHODS: Fifty-four dogs were divided into three groups: localized demodicosis (LD, n = 16), generalized demodicosis (GD, n = 22), and control group (CG, n = 16). All dogs were subjected to skin scraping, blood collection, and skin biopsy...
June 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29907144/a-rare-chd5-haplotype-and-its-interactions-with-environmental-factors-predicting-hepatocellular-carcinoma-risk
#9
Qin Xiao, Lianzhou Chen, Haiqing Luo, Hongmei Li, Qingming Kong, Fei Jiao, Shifeng Pang, Ming Zhang, Feifei Lan, Wenguo Fan, Hui Luo, Tao Tao, Xiao Zhu
BACKGROUND: CHD5 is a conventional tumour-suppressing gene in many tumours. The aim of this study was to determine whether CHD5 variants contribute to the risk of hepatocellular carcinoma (HCC). METHODS: Gene variants were identified using next-generation sequencing targeted on referenced mutations followed by TaqMan genotyping in two case-control studies. RESULTS: We discovered a rare variant (haplotype AG) in CHD5 (rs12564469-rs9434711) that was markedly associated with the risk of HCC in a Chinese population...
June 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29907142/malbac-based-chromosomal-imbalance-analysis-a-novel-technique-enabling-effective-non-invasive-diagnosis-and-monitoring-of-bladder-cancer
#10
Hao Liu, Wang He, Bo Wang, Kewei Xu, Jinli Han, Junjiong Zheng, Jun Ren, Lin Shao, Shiping Bo, Sijia Lu, Tianxin Lin, Jian Huang
BACKGROUND: The gold standard for bladder cancer detection is cystoscopy, which is an invasive procedure that causes discomfort in patients. The currently available non-invasive approaches either show limited sensitivity in low-grade tumours or possess unsatisfying specificity. The aim of the present study is to develop a new non-invasive strategy based on chromosomal imbalance levels to detect bladder cancer effectively. METHODS: We enrolled 74 patients diagnosed with bladder cancer (BC), 51 healthy participants and 27 patients who were diagnosed with non-malignant urinary disease (UD)...
June 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29907081/genome-wide-surveys-reveal-polarity-and-cytoskeletal-regulators-mediate-lkb1-associated-germline-stem-cell-quiescence
#11
Pratik Kadekar, Rita Chaouni, Emily Clark, Anna Kazanets, Richard Roy
BACKGROUND: Caenorhabditis elegans can endure long periods of environmental stress by altering their development to execute a quiescent state called "dauer". Previous work has implicated LKB1 - the causative gene in the autosomal dominant, cancer pre-disposing disease called Peutz-Jeghers Syndrome (PJS), and its downstream target AMPK, in the establishment of germline stem cell (GSC) quiescence during the dauer stage. Loss of function mutations in both LKB1/par-4 and AMPK/aak(0) result in untimely GSC proliferation during the onset of the dauer stage, although the molecular mechanism through which these factors regulate quiescence remains unclear...
June 15, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29906694/photo-induced-antibacterial-activity-of-a-porphyrin-derivative-isolated-from-the-harmful-dinoflagellate-heterocapsa-circularisquama
#12
Li Wencheng, Kichul Cho, Yasuhiro Yamasaki, Satoshi Takeshita, Kiju Hwang, Daekyung Kim, Tatsuya Oda
The dinoflagellate Heterocapsa circularisquama is highly toxic to bivalves. However, significant toxicity to finfish species has not been reported. We previously found that H. circularisquama has light-dependent haemolytic agents. Purification and chemical structural analyses revealed that the haemolytic agent H2-a is a porphyrin derivative, which exhibits light-dependent cytotoxicity toward tumour cells. To clarify the biological activity of H2-a further, its antibacterial activities against Gram-positive and Gram-negative bacteria were investigated in this study...
June 7, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29906537/phenolic-acid-and-flavonoid-rich-fraction-of-sasa-quelpaertensis-nakai-leaves-prevent-alcohol-induced-fatty-liver-through-ampk-activation
#13
Kalahe Hewage Iresha Nadeeka Madushani Herath, Jinhee Cho, Areum Kim, Tae Kil Eom, Ju-Sung Kim, Jae-Bum Kim, Yang Hoi Doh, Youngheun Jee
ETHNOPHARMACOLOGICAL RELEVANCE: Sasa quelpaertensis Nakai is an edible dwarf bamboo cultivated mainly in Jeju Island, South Korea and its leaf displays various health-promoting properties including antioxidant scavenging. AIM OF THE STUDY: In this study, we aimed at elucidating its hepatoprotective effect against alcohol-induced fatty liver. METHODS: In in vitro study, we evaluated the cytotoxicity and hepatoprotective effect of different solvent fractions (aqua, butanol, chloroform, ethyl acetate and hexane) of 80% EtOH extract of S...
June 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29906238/an-appreciation-of-the-science-and-philanthropy-of-sir-oliver-scott-founder-of-the-gray-cancer-institute
#14
Barry Danby Michael
This Commentary focuses on the landmark paper about hypoxia in radiotherapy by Gray, Scott et al published in 1953. By then, it was known that hypoxic regions in tumours could make them resistant to radiation treatment and that this was a possible cause of failure. The paper proposed that oxygen breathing could substantially decrease this resistance without incurring significant additional damage to normal tissues, thus reducing the likelihood of recurrence. Although the paper's supporting data were in some respects incomplete, the case it made was convincing and it prompted pilot clinical trials that combined radiotherapy with oxygen breathing, including under elevated pressure...
June 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29905981/alterations-in-desmosomal-adhesion-at-protein-and-ultrastructure-levels-during-the-sequential-progressive-grades-of-human-oral-tumorigenesis
#15
Sharada Sawant, Harsh Dongre, Chetan Ahire, Shilpi Sharma, Sayli Jamghare, Yashvi Kansara, Pallavi Rane, Deepak Kanojia, Asawari Patil, Devendra Chaukar, Sudeep Gupta, Anil D'Cruz, Milind Vaidya, Prabhakar Dongre
With the aim of developing early diagnostic/prognostic markers for oral cancer, desmosomal adhesion in sequentially progressive grades of tissues from oral normal/disorders (normal, hyperplastic, dysplastic, non-metastatic/metastatic tumours, and metastatic nodes) was investigated at protein and ultrastructural levels using immunohistochemistry and transmission electron microscopy, respectively. The expression of desmosomal proteins was higher in hyperplastic tissues than in normal tissues but was significantly decreased in subsequent progressive stages of the disease...
June 15, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29905800/superior-and-inferior-vena-cava-obstruction-an-unusual-presentation-of-a-rare-primary-cardiac-tumour
#16
Polonca Kogoj, Rok Zbacnik, Zvezdana Dolenc-Stražar, Tomislav Klokocovnik, Marta Cvijic
No abstract text is available yet for this article.
June 13, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29905434/the-role-of-steroid-metabolome-analysis-for-the-diagnosis-and-follow-up-of-adrenocortical-tumours
#17
Vasileios Chortis
The diagnostic work up of adrenal tumours, often incidentally discovered, has emerged as an ever-increasing diagnostic problem for clinical endocrinologists. No imaging modality has sufficiently high sensitivity and specificity at differentiating benign from malignant adrenal lesions. It has long been observed that adrenocortical carcinomas (ACCs) present an immature pattern of steroidogenesis, dominated by steroid hormone precursors. Modern mass spectrometry-based assays can generate multi-steroid metabolite profiles in urine collections, which can detect differences between ACCs and benign adrenocortical adenomas (ACAs)...
June 14, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29905156/two-cases-of-opercular-myoclonic-anarthric-status-epilepticus
#18
Amaia Muñoz-Lopetegi, Gorka Fernández García de Eulate, Jon Rodríguez-Antigüedad Muñoz, Alberto Bergareche, Juan José Poza
Opercular myoclonic-anarthric status epilepticus (OMASE) is a rare form of epilepsia partialis continua presenting as fluctuating dysarthria, or even anarthria. The condition is caused by an epileptogenic lesion involving the opercular cortex of either hemisphere. Speech impairment is secondary to bilateral epileptic activity affecting the glossopharyngeal muscles. This bilateral nature of the condition is due to the fact that innervation of cranial nerves V, VII, IX, X and XII from the opercular area of the primary motor cortex is bilateral...
June 15, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29904728/transcriptomic-profiling-of-human-skin-biopsies-in-the-clinical-trial-setting-a-protocol-for-high-quality-rna-extraction-from-skin-tumours
#19
Marina Danilenko, Robert Stones, Neil Rajan
Transcriptomic profiling of skin disease using next generation sequencing allows for detailed information on aspects of RNA biology including gene expression, non-coding regulatory elements and gene splicing. The application of RNA sequencing to human skin disease and cancer is often hampered by degraded RNA. Here we describe a protocol that allows for consistently intact RNA to be extracted from snap frozen skin biopsy samples, which has been validated in a clinical trial setting. Human skin tumour punch biopsies (n=28) ranging from 4-6mm in diameter were obtained from 14 patients with an inherited skin tumour syndrome (CYLD cutaneous syndrome) and frozen in liquid nitrogen prior to being stored at -80°C...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29904193/cancer-re-educating-tumour-associated-macrophages-with-nanoparticles
#20
Megan Cully
No abstract text is available yet for this article.
June 15, 2018: Nature Reviews. Drug Discovery
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