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https://www.readbyqxmd.com/read/29691994/chemical-biochemical-preclinical-and-clinical-studies-of-ganoderma-lucidum-polysaccharide-as-an-approved-drug-for-treating-myopathy-and-other-diseases-in-china
#1
REVIEW
Pengjiao Zeng, Zhihua Guo, Xuan Zeng, Cui Hao, Yiran Zhang, Meng Zhang, Yong Liu, Hui Li, Juan Li, Lijuan Zhang
Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. It is a highly prized vitality-enhancing herb for more than 2000 years. G. lucidum polysaccharide (GLPS) has been identified as one of the major bioactive components and developed into a drug named "Ji 731 Injection" in China since 1973. The large-scale production of the drug began in 1985 and approved by the Chinese FDA as "Polysaccharidum of G. lucidum Karst Injection" (Ling Bao Duo Tang Zhu She Ye) in 2000, which is applied intramuscularly...
April 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29691857/primary-tonsillar-mast-cell-tumour-in-a-dog
#2
C C Shekell, M J Thomson, R I Miller, J T Mackie
CASE REPORT: A 6-year-old speyed female Bull Arab-cross dog was found to have a small tonsillar nodule. Histological examination revealed a well-differentiated mast cell tumour (MCT). At initial staging, no evidence of concurrent cutaneous or visceral MCTs was found on a complete blood count, a single lateral thoracic radiograph, abdominal ultrasound or cytology of the spleen and regional lymph nodes. A diagnosis of primary tonsillar MCT was made. At 40 months postoperatively, the dog is alive with no evidence of gross tumour progression, in contrast to some previous reports of rapid disease progression and metastasis in dogs with primary oral MCTs...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29691856/in-this-issue-may-2018-antimicrobial-labelling-in-australia-%C3%A2-queensland-survey-of-rabies-vaccination-%C3%A2-antibody-response-to-hev-vaccine-%C3%A2-response-to-ibdv-infection-in-chickens-%C3%A2-outbreaks-of-winter-scours-in-merino-sheep-%C3%A2-tonsillar-mast-cell-tumour-in-a
#3
EDITORIAL
https://www.readbyqxmd.com/read/29691844/genetic-and-morphological-evaluation-game-score-for-patients-with-colorectal-liver-metastases
#4
G A Margonis, K Sasaki, S Gholami, Y Kim, N Andreatos, N Rezaee, A Deshwar, S Buettner, P J Allen, T P Kingham, T M Pawlik, J He, J L Cameron, W R Jarnagin, C L Wolfgang, M I D'Angelica, M J Weiss
BACKGROUND: This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS. METHODS: A cohort of patients who underwent resection for CRLM at the Johns Hopkins Hospital (JHH) was analysed to identify independent predictors of overall survival (OS) that can be assessed before operation; these factors were combined into the Genetic And Morphological Evaluation (GAME) score...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691839/gene-expression-profiles-for-a-prognostic-immunoscore-in-gastric-cancer
#5
D Zeng, R Zhou, Y Yu, Y Luo, J Zhang, H Sun, J Bin, Y Liao, J Rao, Y Zhang, W Liao
BACKGROUND: Increasing evidence has indicated an association between immune infiltration in gastric cancer and clinical outcome. However, reliable prognostic signatures, based on systematic assessments of the immune landscape inferred from bulk tumour transcriptomes, have not been established. The aim was to develop an immune signature, based on the cellular composition of the immune infiltrate inferred from bulk tumour transcriptomes, to improve the prognostic predictions of gastric cancer...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691476/lymphomas-driven-by-epstein-barr-virus-nuclear-antigen-1-ebna1-are-dependant-upon-mdm2
#6
Sana AlQarni, Yazeed Al-Sheikh, Donald Campbell, Mark Drotar, Adele Hannigan, Shelagh Boyle, Pawel Herzyk, Andrew Kossenkov, Kate Armfield, Lauren Jamieson, Mariarca Bailo, Paul M Lieberman, Penelope Tsimbouri, Joanna B Wilson
Epstein-Barr virus (EBV)-associated Burkitt's lymphoma is characterised by the deregulation of c-Myc expression and a restricted viral gene expression pattern in which the EBV nuclear antigen-1 (EBNA1) is the only viral protein to be consistently expressed. EBNA1 is required for viral genome propagation and segregation during latency. However, it has been much debated whether the protein plays a role in viral-associated tumourigenesis. We show that the lymphomas which arise in EµEBNA1 transgenic mice are unequivocally linked to EBNA1 expression and that both C-Myc and Mdm2 deregulation are central to this process...
April 25, 2018: Oncogene
https://www.readbyqxmd.com/read/29691287/systematic-modelling-and-design-evaluation-of-unperturbed-tumour-dynamics-in-xenografts
#7
Zinnia P Patricia Parra Guillen, Victor Mangas Sanjuan, Maria Garcia-Cremades, Inaki F Troconiz, Gary Mo, Celine Pitou, Philip W Iversen, Johan E Wallin
Xenograft mice are largely used to evaluate the efficacy of oncological drugs during preclinical phases of drug discovery and development. Mathematical models provide a useful tool to quantitatively characterise tumour growth dynamics and also optimise upcoming experiments. To the best of our knowledge, this is the first report where unperturbed growth of a large set of tumour cell lines (n=28) has been systematically analysed using the model proposed by Simeoni in the context of non-linear mixed effect (NLME)...
April 24, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29691145/extended-endoscopic-endonasal-surgery-for-clival-chordoma-and-chondrosarcoma-our-experience-in-14-cases
#8
Diego Culebras, Jorge Torales, Luis Alberto Reyes, Luis Zapata, Sergio García, Pedro Roldán, Cristóbal Langdon, Issam Alobid, Joaquim Enseñat
OBJECTIVE: To report our experience in the management of chordoma and chondrosarcoma with extended endoscopic endonasal surgery. METHOD: We performed a retrospective analysis of a series of 14 patients with clival chordoma or chondrosarcoma who had extended endoscopic endonasal surgery from 2008 to 2016 performed by the same multidisciplinary team. RESULTS: We had fourteen patients (male/female 2:1), with a mean age of 49years for chordoma and 32 for chondrosarcoma...
April 21, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29689643/il-17a-promotes-the-invasion-metastasis-cascade-via-the-akt-pathway-in-hepatocellular-carcinoma
#9
Qing-Guo Xu, Jian Yu, Xing-Gang Guo, Guo-Jun Hou, Sheng-Xian Yuan, Yuan Yang, Yun Yang, Hui Liu, Ze-Ya Pan, Fu Yang, Fang-Ming Gu, Wei-Ping Zhou
We previously demonstrated that interleukin-17A (IL-17A) is associated with the progression of hepatocellular carcinoma (HCC). However, its role in the invasion-metastasis cascade of HCC and the efficacy of IL-17A-targeting therapeutics in HCC remain largely unknown. In this study, we found that IL-17A promoted intrahepatic and pulmonary metastasis of HCC cells in an orthotopic implant model. Moreover, our results showed that IL-17A induced epithelial-mesenchymal transition (EMT) and promoted HCC cell colonization in vitro and in vivo, and the role of IL-17A in invasion-metastasis was dependent on activation of the AKT pathway...
April 24, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29689363/a-review-of-the-genotoxic-mutagenic-and-carcinogenic-potentials-of-several-lower-acrylates
#10
REVIEW
Mina Suh, Deborah Proctor, Grace Chappell, Julia Rager, Chad Thompson, Susan Borghoff, Lavorgie Finch, Robert Ellis-Hutchings, Karin Wiench
Lower alkyl acrylate monomers include methyl-, ethyl-, n-butyl-, and 2-ethylhexyl acrylate. These acrylates are used in the manufacture of acrylic polymers and copolymers for plastics, food packaging, adhesives, and cosmetic formulations. Although there is limited potential for human environmental exposure, occupational exposure can occur via inhalation and dermal contact. Recently, new genotoxicity data have been generated, along with in silico and in vitro read-cross analyses, for these acrylates. The availability of high-throughput screening (HTS) data through the ToxCast™/Tox21 databases allows for consideration of computational toxicology and organization of these data according to the ten key characteristics of carcinogens...
April 21, 2018: Toxicology
https://www.readbyqxmd.com/read/29689238/pseudomesotheliomatous-type-of-sarcomatoid-squamous-cell-lung-cancer-presenting-with-hemothorax
#11
Niravkumar K Sangani, Santosh Mathew Naliath
A 44 year old male presented with spontaneous massive hemothorax. Computed tomography (CT) scan revealed thickened and nodular pleura with no evidence of lung tumour. Patient underwent right open total pleurectomy. Histopathology and Immunohistochemistry studies of the pleura confirmed poorly differentiated sarcomatoid squamous cell carcinoma of lung with metastasis to pleura. The carcinoma was psuedomesothelimatous type due to its presentation as diffuse pleural thickening. This presentation of sarcomatoid cancer as pseudomesotheliomatous type with massive hemothorax is rare and can be considered as differential diagnosis in diffuse pleural thickening or hemothorax, especially in absence of clinically identifiable primary lung tumour...
April 21, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29688881/surveillance-guidelines-based-on-recurrence-patterns-for-upper-tract-urothelial-carcinoma
#12
Jennifer A Locke, Reza Hamidizadeh, Wassim Kassouf, R Ricardo Rendon, David Bell, Jonathan Izawa, J Joseph Chin, Anil Kapoor, Bobby Shayegen, Jean-Baptiste Lattouf, Fred Saad, Louis Lacombe, Yves Fradet, Adrien Fairey, Niels-Eric Jacobson, Darrel Drachenberg, Ilias Cagiannos, Alan So, Peter C Black
INTRODUCTION: Upper tract urothelial carcinoma (UTUC) accounts for 5% of all urothelial tumours. Due to its rarity, evidence regarding postoperative surveillance is lacking. The objective of this study was to develop a post-radical nephroureterectomy (RNU) surveillance protocol based on recurrence patterns in a large, multi-institutional cohort of patients. METHODS: Retrospective clinical and pathological data were collected from 1029 patients undergoing RNU over a 15-year period (1994-2009) at 10 Canadian academic institutions...
April 12, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29688585/reappraisal-of-classification-of-distal-cholangiocarcinoma-based-on-tumour-depth
#13
H Aoyama, T Ebata, M Hattori, M Takano, H Yamamoto, M Inoue, Y Asaba, M Ando, M Nagino
BACKGROUND: In the eighth edition of the AJCC cancer staging classification, the T system for distal cholangiocarcinoma (DCC) has been revised from a layer-based to a depth-based approach. The aim of this study was to propose an optimal T classification using a measured depth in resectable DCC. METHODS: Patients who underwent pancreatoduodenectomy for DCC at 32 hospitals between 2001 and 2010 were included. The distance between the level of the naive bile duct and the deepest cancer cells was measured as depth of invasion (DOI)...
April 24, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29688280/the-occurrence-of-benign-brain-tumours-in-transgender-individuals-during-cross-sex-hormone-treatment
#14
Nienke M Nota, Chantal M Wiepjes, Christel J M de Blok, Louis J G Gooren, Saskia M Peerdeman, Baudewijntje P C Kreukels, Martin den Heijer
Benign brain tumours may be hormone sensitive. To induce physical characteristics of the desired gender, transgender individuals often receive cross-sex hormone treatment, sometimes in higher doses than hypogonadal individuals. To date, long-term (side) effects of cross-sex hormone treatment are largely unknown. In the present retrospective chart study we aimed to compare the incidence of common benign brain tumours: meningiomas, pituitary adenomas (non-secretive and secretive), and vestibular schwannomas in transgender individuals receiving cross-sex hormone treatment, with those reported in general Dutch or European populations...
April 23, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29688026/incidental-pulmonary-embolism-in-oncology-patients-with-current-macroscopic-malignancy-incidence-in-different-tumour-type-and-impact-of-delayed-treatment-on-survival-outcome
#15
Maung Maung Myat Moe, Sridhar Redla
OBJECTIVES: To evaluate the incidence and outcome of incidental PE (iPE) in patients with current macroscopic malignancy and delayed anticoagulation due to late reporting of CT scan. METHODS: Reports of CT thorax with iv contrast done on oncology patients between 01.01.15 and 31.12.15 in two district general hospitals in UK were reviewed. Electronic patient records of iPE patients were reviewed for demographic and treatment information. RESULTS: 26 iPEs were reported in 1,604 scans (731 patients), incidence 1...
April 24, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29687953/has-tailored-tissue-selective-tumour-ablation-in-men-with-prostate-cancer-come-of-age
#16
EDITORIAL
Mark Emberton
No abstract text is available yet for this article.
May 2018: BJU International
https://www.readbyqxmd.com/read/29687553/model-predicting-the-microvascular-invasion-and-satellite-lesions-of-hepatocelluar-carcinoma-after-hepatectomy
#17
Junyi Shen, Tianfu Wen, Weixia Chen, Changli Lu, Lvnan Yan, Jiayin Yang
BACKGROUND: Microvascluar invasion and satellite lesion (MS), important unfavourable pathological factors, significantly contribute to tumour recurrence and impair the prognosis in hepatocelluar carcinoma. We aimed to construct a model for the prediction of MS in order to plan treatment better. METHODS: A total of 1135 consecutive patients with hepatocelluar carcinoma who received radical hepatectomy at West China Hospital were randomly assigned to a training set and a validation set...
April 24, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29687464/protective-effects-of-sea-cucumber-holothuria-atra-extract-on-testicular-dysfunction-induced-by-immune-suppressant-drugs-in-wistar-rats
#18
D Y Saad, M M Soliman, A A Mohamed, G B Youssef
The current study was aimed to evaluate the protective effect of Holothurian atra (HA) extract; naturally occurring marine resource, against methotrexate (MTX) induced testicular dysfunction. Mature rats received either MTX (20 mg/kg, intraperitoneally) or saline on the 7th day of experiment al design. Seven days prior and after MTX-injection, rats received HA at dose of 300 mg/kg intragastrically (HA + MTX group; HA group alone). Serum was extracted and testicular tissues were examined for the changes in serum biochemistry (liver & kidney biomarkers, testicular hormones and antioxidants), molecular and histopthological alterations using RT-PCR and immunohistochemistry...
April 23, 2018: Andrologia
https://www.readbyqxmd.com/read/29687416/mrecist-criteria-to-assess-recurrent-thyroid-carcinoma-treatment-response-after-radiofrequency-ablation-a-prospective-study
#19
S Mazzeo, R Cervelli, R Elisei, G Tarantini, C Cappelli, E Molinaro, D Galleri, L De Napoli, C Comite, R Cioni, P Vitti, D Caramella
PURPOSE: Surgical removal is recommended for recurrent thyroid carcinomas (RTCs) unable to uptake radioiodine and/or not responsive to chemotherapy. However, repeated neck dissection is difficult for surgeons. Thus, radiofrequency ablation (RFA) was proposed for RTCs. The aim of this prospective study is to assess RTC treatment response after RFA, according to well-established criteria. METHODS: Sixteen lesions in 13 patients were treated by RFA. All patients refused/were excluded from repeated surgery or other conventional therapy...
April 23, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29687283/extended-endoscopic-supracerebellar-infratentorial-eesi-approach-for-a-complex-pineal-region-tumour-a-technical-note
#20
Saurabh Sinha, Elizabeth Culpin, John McMullan
Endoscopic-assisted approaches have been shown to be a suitable alternative to the standard microscopic approach to pineal region tumours. With extension laterally into the ventricles, the 0° endoscope and microscope have significant limitations. We describe the extended endoscopic supracerebellar infratentorial (EESI) approach using angled endoscopes for a complex pineal region tumour that extended into the lateral ventricle. A 15-year-old boy presented with headaches and ataxia. MRI revealed a pineal region tumour extending into the lateral ventricle...
April 23, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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