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https://www.readbyqxmd.com/read/29677358/lysophosphatidic-acid-induces-ecm-production-via-activation-of-the-mechanosensitive-yap-taz-transcriptional-pathway-in-trabecular-meshwork-cells
#1
Leona T Y Ho, Nikolai Skiba, Christoph Ullmer, Ponugoti Vasantha Rao
Purpose: Lysophosphatidic acid (LPA), a bioactive lipid, has been shown to increase resistance to aqueous humor outflow (AH) through the trabecular meshwork (TM). The molecular basis for this response of the TM to LPA, however, is not completely understood. In this study, we explored the possible involvement of mechanosensitive Yes-associated protein (YAP) and its paralog, transcriptional coactivator with PDZ-binding domain (TAZ), transcriptional activation in extracellular matrix (ECM) production by LPA-induced contractile activity in human TM cells (HTM)...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29662755/cyr61-an-angiogenic-biomarker-to-early-predict-the-impaired-healing-in-diaphyseal-tibial-fractures
#2
Sabir Ali, Ajai Singh, Abbas Ali Mahdi, Rajeshwar Nath Srivastava
Background: Angiogenesis is a prerequisite for fracture repair, whereas insufficient blood supply is likely to result in impaired healing. In the present study, we aimed to determine the correlation of simple tibial fracture healing outcome with serial estimation of CYR61 expressions in the early phase of healing. Methods: In total, 107 adult fractured patients and 97 healthy controls were analysed. Peripheral blood samples were taken from controls (at once) and fractured patients at 4th , 7th , 10th , 15th , 20th and 28th days of post-fracture follow-ups to quantify the CYR61 mRNA and protein expression by qRT-PCR and Western blotting assay, respectively...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29644781/inpp4b-overexpression-and-c-kit-downregulation-in-human-achalasia
#3
E Bonora, F Bianco, A Stanzani, F Giancola, A Astolfi, V Indio, C Evangelisti, A M Martelli, E Boschetti, M Lugaresi, A Ioannou, F Torresan, V Stanghellini, P Clavenzani, M Seri, A Moonen, K Van Beek, M Wouters, G E Boeckxstaens, G Zaninotto, S Mattioli, R De Giorgio
BACKGROUND: Achalasia is a rare motility disorder characterized by myenteric neuron and interstitial cells of Cajal (ICC) abnormalities leading to deranged/absent peristalsis and lack of relaxation of the lower esophageal sphincter. The mechanisms contributing to neuronal and ICC changes in achalasia are only partially understood. Our goal was to identify novel molecular features occurring in patients with primary achalasia. METHODS: Esophageal full-thickness biopsies from 42 (22 females; age range: 16-82 years) clinically, radiologically, and manometrically characterized patients with primary achalasia were examined and compared to those obtained from 10 subjects (controls) undergoing surgery for uncomplicated esophageal cancer (or upper stomach disorders)...
April 11, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29575795/synthesis-and-effect-of-a-new-terbium-gibberellic-complex-on-the-histopathological-alteration-induced-by-gibberellic-acid-on-liver-and-kidney-of-mice-mus-musculus
#4
Amin A Seleem, Belal H M Hussein
The objective of this study was to synthesize Gibberellic lanthanide complex and evaluate its biological activity to reduce the Gibberellic acid toxicity on liver and kidney. The new bis (Gibberellic)-nitro-terbium(III) complex was characterized by different analytical methods: elemental analyses, Uv-vis, molar ratio, fluorescence, FT-IR, and TGA-DTA measurements. Thirty newborns were classified into three groups control, Gibberellic acid, and Terbium gibberellic acid complex. Livers and kidneys of studied groups proceed for general histology and immunohistochemical staining of Cyr61, cytochrome C, and TNFR2...
March 25, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29575527/inhibition-of-yes-associated-protein-suppresses-brain-metastasis-of-human-lung-adenocarcinoma-in-a-murine-model
#5
Ping-Chih Hsu, Jinbai Miao, Zhen Huang, Yi-Lin Yang, Zhidong Xu, Joanna You, Yuyuan Dai, Che-Chung Yeh, Geraldine Chan, Shu Liu, Anatoly Urisman, Cheng-Ta Yang, David M Jablons, Liang You
Yes-associated protein (YAP) is a main mediator of the Hippo pathway and promotes cancer development and progression in human lung cancer. We sought to determine whether inhibition of YAP suppresses metastasis of human lung adenocarcinoma in a murine model. We found that metastatic NSCLC cell lines H2030-BrM3(K-rasG12C mutation) and PC9-BrM3 (EGFRΔexon19 mutation) had a significantly decreased p-YAP(S127)/YAP ratio compared to parental H2030 (K-rasG12C mutation) and PC9 (EGFRΔexon19 mutation) cells (P < ...
March 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29535639/vascular-endothelial-cell-specific-connective-tissue-growth-factor-ctgf-is-necessary-for-development-of-chronic-hypoxia-induced-pulmonary-hypertension
#6
Liya Pi, Chunhua Fu, Yuanquing Lu, Junmei Zhou, Marda Jorgensen, Vinayak Shenoy, Kenneth E Lipson, Edward W Scott, Andrew J Bryant
Chronic hypoxia frequently complicates the care of patients with interstitial lung disease, contributing to the development of pulmonary hypertension (PH), and premature death. Connective tissue growth factor (CTGF), a matricellular protein of the Cyr61/CTGF/Nov (CCN) family, is known to exacerbate vascular remodeling within the lung. We have previously demonstrated that vascular endothelial-cell specific down-regulation of CTGF is associated with protection against the development of PH associated with hypoxia, though the mechanism for this effect is unknown...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29510193/ccn1-cyr61-stimulates-melanogenesis-through-integrin-%C3%AE-6%C3%AE-1-p38-mapk-and-erk1-2-signaling-pathways-in-human-epidermal-melanocytes
#7
Zhongyi Xu, Li Chen, Min Jiang, Qianqian Wang, Chengfeng Zhang, Leihong Flora Xiang
Fibroblast-derived melanogenic paracrine mediators are known to play a role in melanogenesis. To investigate the effect of CCN1 (also called CYR61 or cysteine-rich 61) on melanogenesis, normal human epidermal melanocytes were treated with recombinant CCN1 protein. Our findings show that CCN1 activates melanogenesis through promoting melanosome maturation and up-regulation of MITF, TRP-1, and tyrosinase via the integrin α6β1, p38 MAPK, and ERK signaling pathways. Furthermore, we found that UVB irradiation stimulates the secretion of CCN1 from normal human dermal fibroblasts, and CCN1 knockdown in fibroblasts attenuates melanogenesis in melanocyte-fibroblast co-culture system...
March 3, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29506624/ccn3-a-key-matricellular-protein-distinctly-inhibits-tgf%C3%AE-1-mediated-smad1-5-8-signalling-in-human-podocyte-culture
#8
Tarunkumar Hemraj Madne, Mark Edward Carl Dockrell
Growth factors like TGFβ and CTGF (CCN2) plays a vital role in various cellular functions. TGFβ and CTGF are overexpressed in renal fibrosis. CTGF act as profibrotic stimuli to TGFβ. CCN3 is a member of CCN family which also comprises CCN1 (CYR61), CCN2 (CTGF), CCN4 (WISP-1), CCN5 (WISP-2) and CCN6 (WISP-3). CCN3 has been shown to antagonise CTGF. In this study, we investigated the role of CCN3 in TGFβ1-mediated signalling in human podocytes culture. This study describes the novel function of CCN3 in regulation of TGFβ1 mediated non-canonical Smad signalling in human podocytes culture...
February 28, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29473317/mir-634-sensitizes-glioma-cells-to-temozolomide-by-targeting-cyr61-through-raf-erk-signaling-pathway
#9
Zhigang Tan, Jizong Zhao, Yugang Jiang
Glioma is the most common intracranial malignant tumors, accounting for about 40% of intracranial tumors. Primary or secondary drug resistance is one of the main reasons for the failure of treatment. The oncogenic or tumor-suppressive roles of miR-634 have been revealed in different types of cancer. However, the role of miR-634 in glioma remains unknown and whether miR-634 could sensitize glioma cells to temozolomide also is unclear. Here, we aim to investigate the biological function of miR-634 and the possible mechanisms in glioma...
March 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29449645/egfr-pi3k-pdk1-pathway-regulates-yap-signaling-in-hepatocellular-carcinoma-the-mechanism-and-its-implications-in-targeted-therapy
#10
Hongwei Xia, Xinyu Dai, Huangfei Yu, Sheng Zhou, Zhenghai Fan, Guoqing Wei, Qiulin Tang, Qiyong Gong, Feng Bi
The epidermal growth factor receptor (EGFR) pathway and Hippo signaling play an important role in the carcinogenesis of hepatocellular carcinoma (HCC). However, the crosstalk between these two pathways and its implications in targeted therapy remains unclear. We found that the activated EGFR signaling could bypass RhoA to promote the expression of YAP(Yes-associated protein), the core effector of the Hippo signaling, and its downstream target Cyr61. Further studies indicated that EGFR signaling mainly acted through the PI3K-PDK1 (Phosphoinositide 3-kinase-Phosphoinositide-dependent kinase-1) pathway to activate YAP, but not the AKT and MAPK pathways...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29414775/the-maz-transcription-factor-is-a-downstream-target-of-the-oncoprotein-cyr61-ccn1-and-promotes-pancreatic-cancer-cell-invasion-via-craf-erk-signaling
#11
Gargi Maity, Inamul Haque, Arnab Ghosh, Gopal Dhar, Vijayalaxmi Gupta, Sandipto Sarkar, Imaan Azeem, Douglas McGregor, Abhishek Choudhary, Donald R Campbell, Suman Kambhampati, Sushanta K Banerjee, Snigdha Banerjee
Myc-associated zinc-finger protein (MAZ) is a transcription factor with dual roles in transcription initiation and termination. Deregulation of MAZ expression is associated with the progression of pancreatic ductal adenocarcinoma (PDAC). However, the mechanism of action of MAZ in PDAC progression is largely unknown. Here, we present evidence that MAZ mRNA expression and protein levels are increased in human PDAC cell lines, tissue samples, a subcutaneous tumor xenograft in a nude mouse model, and spontaneous cancer in the genetically engineered PDAC mouse model...
March 23, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29407579/skin-and-scale-regeneration-after-mechanical-damage-in-a-teleost
#12
Rita A Costa, Deborah M Power
Skin wound healing has been widely studied in mammalian models but the information on teleost cutaneous healing is sparse and frequently considered in the context of viral or bacterial infections or parasitic infestations in aquaculture. In the present study a detailed time course (0 h, 6 h, 1, 2, 3 and 4 days) coupled to morphology and gene expression analysis revealed rapid regeneration of skin without scarring in a marine teleost after a superficial wound caused by the loss of a large area of scales...
March 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29401606/cysteine-rich-protein-61-regulates-adipocyte-differentiation-from-mesenchymal-stem-cells-through-mammalian-target-of-rapamycin-complex-1-and-canonical-wnt-signaling
#13
Yongxu Yang, Qi Qi, Yi Wang, Yaru Shi, Weili Yang, Yunzhu Cen, Endong Zhu, Xiaoxia Li, Di Chen, Baoli Wang
Emerging evidence suggests that cysteine-rich protein 61 (CYR61) plays a role in the differentiation and development of chondrocytes, osteoblasts, and osteoclasts; however, little is known about its role in adipogenesis. The current study indicates that the expression level of Cyr61 was altered in primary cultured marrow stromal cells and the established mesenchymal cell line, C3H10T1/2, after adipogenic treatment. Overexpressing Cyr61 repressed C3H10T1/2 and primary marrow stromal cells to differentiate into mature adipocytes...
January 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29368096/decitabine-augments-cytotoxicity-of-cisplatin-and-doxorubicin-to-bladder-cancer-cells-by-activating-hippo-pathway-through-rassf1a
#14
Madhuram Khandelwal, Vivek Anand, Sandeep Appunni, Amlesh Seth, Prabhjot Singh, Sandeep Mathur, Alpana Sharma
Genetic abnormalities and epigenetic alterations both play vital role in initiation as well as progression of cancer. Whereas genetic mutations cannot be reversed, epigenetic alterations such as DNA methylation can be reversed by the application of DNA methyltransferase inhibitor decitabine. Epigenetic silencing of RASSF1A and involvement of hippo pathway both have been shown to involve in chemo-resistance. Purpose of this study was to observe the effect of combination treatment of decitabine with cisplatin or doxorubicin on bladder cancer cells involving hippo pathway through RASSF1A...
January 24, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29364834/quercetin-suppresses-cyr61-mediated-multidrug-resistance-in-human-gastric-adenocarcinoma-ags-cells
#15
Ho Bong Hyun, Jeong Yong Moon, Somi Kim Cho
Cysteine-rich angiogenic inducer 61 (CYR61) is an extracellular matrix-associated protein involved in survival, tumorigenesis, and drug resistance. Therefore, we examined the effects of flavones against CYR61-overexpressing human gastric adenocarcinoma AGS (AGS-cyr61) cells, which show remarkable resistance to 5-fluorouracil (5-FU), adriamycin (ADR), tamoxifen (TAM), paclitaxel (PAC), and docetaxel (DOC). Among the tested flavones, quercetin had the lowest 50% inhibitory concentration (IC50 ) and significantly reduced the viability of AGS-cyr61 cells compared with AGS cells...
January 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29357009/the-matricellular-protein-ccn1-in-tissue-injury-repair
#16
REVIEW
Ki-Hyun Kim, Jong Hoon Won, Naiyuan Cheng, Lester F Lau
The expression of Ccn1 (Cyr61) is essential for cardiovascular development during embryogenesis, whereas in adulthood it is associated with inflammation, wound healing, injury repair, and related pathologies including fibrosis and cancer. Recent studies have found that CCN1 plays a critical role in promoting wound healing and tissue repair. Mechanistically, CCN1 functions through direct interaction with specific integrin receptors expressed in various cell types in the wound tissue microenvironment to coordinate diverse cellular functions for repair...
March 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29351359/cyr61-ccn1-regulates-sclerostin-levels-and-bone-maintenance
#17
Gexin Zhao, Bau-Lin Huang, Diana Rigueur, Weiguang Wang, Chimay Bhoot, Kemberly R Charles, Jongseung Baek, Subburaman Mohan, Jie Jiang, Karen M Lyons
CYR61/CCN1 is a matricellular protein that resides in the extracellular matrix, but serves regulatory rather than structural roles. CYR61/CCN1 is found in mineralized tissues and has been shown to influence bone healing in vivo and osteogenic differentiation in vitro. In this study we generated Cyr61 bone-specific knockout mice to examine the physiological role of CYR61/CCN1 in bone development and maintenance in vivo. Extensive analysis of Cyr61 conditional knockout mice showed a significant decrease in both trabecular and cortical bone mass as compared to WT littermates...
January 19, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29345157/evaluation-of-serum-cysteine-rich-protein-61-levels-in-patients-with-coronary-artery-disease
#18
Jingang Deng, Xiaoxian Qian, Jianping Li, Yanghua Li, Yang Li, Yijun Luo
AIM: The aim is to evaluate serum cysteine-rich protein 61 (Cyr61) levels in patients with coronary artery disease (CAD). PATIENTS & METHODS: Serum Cyr61 levels were measured in 180 patients with CAD and 74 participants without CAD. RESULTS: Serum Cyr61 levels were significantly higher in CAD patients. Patients with acute coronary syndrome showed significantly higher Cyr61 than those with stable angina pectoris. Serum Cyr61 levels in complex lesion group were significantly higher...
January 18, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29336471/neuroprotective-effects-of-p53-microrna%C3%A2-22-regulate-inflammation-and-apoptosis-in-subarachnoid-hemorrhage
#19
Shui Yu, Yi-Jun Zeng, Xiao-Chuan Sun
The present study aimed to investigate whether the neuroprotective effects of p53/microRNA‑22 regulate inflammation and apoptosis in subarachnoid hemorrhage (SAH). In a mouse model of SAH, microRNA‑22 expression was upregulated. In addition, downregulation of microRNA‑22 in HEB cells increased the mRNA expression levels of interleukin (IL)‑6, induced cysteine rich angiogenic inducer 61 (Cyr61) expression, and suppressed the protein expression levels of B‑cell lymphoma 2‑associated X protein (Bax) and caspase‑3 activity...
April 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29319180/wisp1-promotes-non-alcoholic-fatty-liver-disease-and-skeletal-muscle-insulin-resistance-via-tlr4-jnk-signaling
#20
Tae Woo Jung, Changmuk Kang, Jiwon Goh, Soo In Chae, Hyoung-Chun Kim, Tae Jin Lee, A M Abd El-Aty, Ji Hoon Jeong
Wnt1-inducible signaling pathway protein-1 (WISP1) is a Cyr61/CTGF/NOV (CCN) family matricellular protein involved in adipogenesis and low-grade inflammation in obesity. However, the roles of WISP1 in hepatic steatosis and insulin resistance in skeletal muscle remain elusive. Mouse primary hepatocytes and differentiated mouse skeletal muscle cells (C2C12) were treated with various concentrations of WISP1 and the functions and signaling pathways were analyzed by Western blot analysis. In vivo transfection for WISP1 knockdown was also performed to examine the effects of WISP1 on hepatic steatosis and skeletal muscle insulin resistance...
January 10, 2018: Journal of Cellular Physiology
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