Cheng Zhang, Wenjing Wei, Shuo Tu, Bo Liang, Chun Li, Yining Li, Weicheng Luo, Yiqing Wu, Xiaohui Dai, Yi Wang, Lijuan Zheng, Liang Hao, Chunbo Zhang, Zhijun Luo, Ye-Guang Chen, Xiaohua Yan
TGF-β and Hippo signaling are two critical pathways engaged in cancer progression by regulating both oncogenes and tumor suppressors, yet how the two pathways coordinately exert their functions in the development of hepatocellular carcinoma (HCC) remains elusive. In this study, we firstly conducted an integrated analysis of public liver cancer databases and our experimental TGF-β target genes, identifying CYR61 as a pivotal candidate gene relating to HCC development. The expression of CYR61 is downregulated in clinical HCC tissues and cell lines than that in the normal counterparts...
March 21, 2024: Journal of Biological Chemistry