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https://www.readbyqxmd.com/read/28945060/benefits-of-micronized-purified-flavonoid-fraction-as-adjuvant-therapy-on-the-inflammatory-response-after-sclerotherapy
#1
Vadim Y Bogachev, Boris V Boldin, Victor N Lobanov
BACKGROUND: Sclerotherapy is the treatment of choice for telangiectasias. The aim of this study was to investigate the systemic and local inflammatory response after sclerotherapy in women with chronic venous disease (CVD) and to assess the effects of micronized purified flavonoid fraction (MPFF) in combination with sclerotherapy on markers of inflammation and endothelial dysfunction. METHODS: 60 women with primary CVD CEAP class C1 were randomly assigned sclerotherapy in combination with MPFF treatment (N=30) or sclerotherapy alone (control) group (N=30)...
September 22, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28944952/bypassing-agent-prophylaxis-in-people-with-hemophilia-a-or-b-with-inhibitors
#2
REVIEW
Chatree Chai-Adisaksopha, Sarah J Nevitt, Mindy L Simpson, Maissaa Janbain, Barbara A Konkle
BACKGROUND: People with hemophilia A or B with inhibitors are at high risk of bleeding complications. Infusion of bypassing agents, such as recombinant activated FVII (rFVIIa) and plasma-derived activated prothrombin complex concentrate, are suggested as alternative therapies to factor VIII (haemophilia A) or IX (haemophilia B) for individuals who no longer respond to these treatments because they develop inhibitory antibodies. The ultimate goal of treatment is to preserve the individual's joints, otherwise destroyed by recurrent bleeds...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944917/application-of-a-co%C3%A2-expression-network-for-the-analysis-of-aggressive-and-non%C3%A2-aggressive-breast-cancer-cell-lines-to-predict-the-clinical-outcome-of-patients
#3
Ling Guo, Kun Zhang, Zhitong Bing
Breast cancer metastasis is a demanding problem in clinical treatment of patients with breast cancer. It is necessary to examine the mechanisms of metastasis for developing therapies. Classification of the aggressiveness of breast cancer is an important issue in biological study and for clinical decisions. Although aggressive and non‑aggressive breast cancer cells can be easily distinguished among different cell lines, it is very difficult to distinguish in clinical practice. The aim of the current study was to use the gene expression analysis from breast cancer cell lines to predict clinical outcomes of patients with breast cancer...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944752/a-randomised-controlled-study-of-the-effectiveness-of-breathing-retraining-exercises-taught-by-a-physiotherapist-either-by-instructional-dvd-or-in-face-to-face-sessions-in-the-management-of-asthma-in-adults
#4
Mike Thomas, Anne Bruton, Paul Little, Stephen Holgate, Amanda Lee, Lucy Yardley, Steve George, James Raftery, Jennifer Versnel, David Price, Ian Pavord, Ratko Djukanovic, Michael Moore, Sarah Kirby, Guiqing Yao, Shihua Zhu, Emily Arden-Close, Manimekalai Thiruvothiyur, Frances Webley, Mark Stafford-Watson, Elizabeth Dixon, Lynda Taylor
BACKGROUND: Asthma control is suboptimal, resulting in quality of life (QoL) impairment and costs. Breathing retraining exercises have evidence of effectiveness as adjuvant treatment, but are infrequently used. OBJECTIVES: To transfer the contents of a brief (three-session) physiotherapist-delivered breathing retraining programme to a digital versatile disc (DVD) and booklet format; to compare the effectiveness of the self-guided intervention with that of 'face-to-face' physiotherapy and usual care for QoL and other asthma-related outcomes; to perform a health economic assessment of both interventions; and to perform a process evaluation using quantitative and qualitative methods...
September 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28944733/performance-based-risk-sharing-arrangements-for-pharmaceutical-products-in-the-united-states-a-systematic-review
#5
Justin S Yu, Lauren Chin, Jennifer Oh, Jorge Farias
BACKGROUND: Value for money is a growing necessity in today's U.S. health care system in which drug spending is expected to increase by an average rate of 6.7% yearly through 2025. In response to uncertainty about real-world clinical and economic outcomes for many drugs, health insurers and pharmacy benefit managers (PBMs) have implemented various contracts and arrangements with drug manufacturers that can collectively be described as performance-based risk-sharing arrangements (PBRSAs)...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944730/optimization-of-medication-use-at-accountable-care-organizations
#6
Chrisanne Wilks, Erik Krisle, Kimberly Westrich, Kristina Lunner, David Muhlestein, Robert Dubois
BACKGROUND: Optimized medication use involves the effective use of medications for better outcomes, improved patient experience, and lower costs. Few studies systematically gather data on the actions accountable care organizations (ACOs) have taken to optimize medication use. OBJECTIVES: To (a) assess how ACOs optimize medication use; (b) establish an association between efforts to optimize medication use and achievement on financial and quality metrics; (c) identify organizational factors that correlate with optimized medication use; and (d) identify barriers to optimized medication use...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944728/performance-based-risk-sharing-arrangements-u-s-payer-experience
#7
Joseph A Goble, Brian Ung, Sascha van Boemmel-Wegmann, Robert P Navarro, Andrew Parece
BACKGROUND: As a result of global concern about rising drug costs, many U.S. payers and European agencies such as the National Health Service have partnered with pharmaceutical companies in performance-based risk-sharing arrangements (PBRSAs) by which manufacturers share financial risk with health care purchasing entities and authorities. However, PBRSAs present many administrative and legal challenges that have minimized successful contract experiences in the United States. OBJECTIVE: To (a) identify drug and disease characteristics and contract components that contribute to successful PBRSA experiences and the primary barriers to PBRSA execution and (b) explore solutions to facilitate contract negotiation and execution...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944603/the-effect-of-side-of-implantation-on-unilateral-cochlear-implant-performance-in-patients-with-prelingual-and-postlingual-sensorineural-hearing-loss-a-systematic-review
#8
Véronique J C Kraaijenga, Tyche C Derksen, Inge Stegeman, Adriana L Smit
OBJECTIVE: Cerebral lateralization of language processing leads to a right ear advantage in normal hearing subjects. The aim of this study was to present a systematic overview of the effect of implantation side on postoperative cochlear implant performance in patients with symmetrical severe to profound sensorineural hearing loss. DATA SOURCES: PubMed, Embase and The Cochrane Library databases. RESEARCH METHODS: Databases were searched from database inception up to January 9(th) 2017 for cochlear implant and side and all synonyms...
September 25, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28944597/caloric-restriction-induced-decreases-in-dopamine-receptor-availability-are-associated-with-leptin-concentration
#9
Julia P Dunn, Naji N Abumrad, Robert M Kessler, Bruce W Patterson, Rui Li, Pamela Marks-Shulman, Robyn A Tamboli
OBJECTIVE: It has been previously reported that early after Roux-en-Y-gastric bypass, dopamine (DA) type 2 and 3 receptor (D2/3R) binding potential (BPND ) was decreased from preoperative levels. The current study aimed to determine whether calorie restriction without weight loss modifies D2/3R BPND and whether such changes are explained by neuroendocrine regulation. METHODS: Fifteen females with obesity (BMI = 39 ± 6 kg/m(2) ) were studied before and after ∼10 days of a very-low-calorie-diet (VLCD)...
September 25, 2017: Obesity
https://www.readbyqxmd.com/read/28944596/diet-quality-in-patients-with-end-stage-kidney-disease-undergoing-dialysis
#10
Lauren A Roach, Kelly Lambert, Jane L Holt, Barbara J Meyer
BACKGROUND: People on haemodialysis (HD) are at risk of consuming a poor quality diet. This includes inadequate intake of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA). OBJECTIVE: This study aims to investigate diet quality, with a particular focus on n-3 LCPUFA intake, in a population of incentre HD patients. DESIGN: Dietary intake was measured using three 24 hour recalls; the Polyunsaturated food frequency questionnaire (PUFA FFQ) and the Total Diet Score (TDS)...
September 24, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28944590/effect-of-the-use-of-earplugs-and-eye-mask-on-the-quality-of-sleep-in-intensive-care-patients-a-systematic-review
#11
REVIEW
Hana Locihová, Karel Axmann, Hana Padyšáková, Jakub Fejfar
Intensive care unit (ICU) environment has a very strong and unavoidable negative impact on patients' sleep. Sleep deprivation in ICU patients has been already studied and negative effects on their outcome (prolonged ICU stay, decreased recovery) and complication rates (incidence of delirium, neuropsychological sequels of critical illness) discussed. Several interventions potentially improving the sleep disturbance in ICU (sleep-promotion strategies) have been assumed and tested for clinical practice. We present a review of recent literature focused on chosen types of non-pharmacological interventions (earplugs and eye mask) analysing their effect on sleep quality/quantity...
September 25, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28944572/sizing-of-patent-ductus-arteriosus-in-adults-for-transcatheter-closure-using-the-balloon-pull-through-technique
#12
Nabil A Shafi, Gagan D Singh, Thomas W Smith, Jason H Rogers
OBJECTIVES: To describe a novel balloon sizing technique used during adult transcatheter patent ductus arteriosus (PDA) closure. In addition, to determine the clinical and procedural outcomes in six patients who underwent PDA balloon sizing with subsequent deployment of a PDA occluder device. BACKGROUND: Transcatheter PDA closure in adults has excellent safety and procedural outcomes. However, PDA sizing in adults can be challenging due to variable defect size, high flow state, or anatomical complexity...
September 25, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28944568/what-patients-and-members-of-their-support-networks-ask-about-transplant-program-data
#13
Cory R Schaffhausen, Marilyn J Bruin, Daryl Chesley, Maureen McBride, Jon J Snyder, Bertram L Kasiske, Ajay K Israni
Transplant patients often seek specific data and statistics to inform medical decision making; however, for many relevant measures, patient-friendly information is not available. Development of patient-centered resources should be informed by patient needs. This study used qualitative document research methods to review 678 detailed Scientific Registry of Transplant Recipients (SRTR) entries and summary counts of 55,362 United Network for Organ Sharing (UNOS) entries to provide a better understanding of what was asked and what requests were most common...
September 25, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28944563/a-randomized-controlled-trial-of-levodopa-in-patients-with-angelman-syndrome
#14
Wen-Hann Tan, Lynne M Bird, Anjali Sadhwani, Rene L Barbieri-Welge, Steven A Skinner, Lucia T Horowitz, Carlos A Bacino, Lisa M Noll, Cary Fu, Rachel J Hundley, Logan K Wink, Craig A Erickson, Gregory N Barnes, Anne Slavotinek, Rita Jeremy, Alexander Rotenberg, Sanjeev V Kothare, Heather E Olson, Annapurna Poduri, Mark P Nespeca, Hillary C Chu, Jennifer M Willen, Kevin F Haas, Edwin J Weeber, Paul A Rufo
Treatment for Angelman syndrome (AS) is currently limited to symptomatic interventions. A mouse model of AS has reduced calcium/calmodulin-dependent kinase II activity due to excessive phosphorylation of specific threonine residues, leading to diminished long-term potentiation. In a rat model of Parkinson disease, levodopa reduced phosphorylation of various proteins, including calcium/calmodulin-dependent kinase II. Further studies demonstrated that AS mice treated with levodopa performed better on rotarod testing than untreated AS mice...
September 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28944553/outcomes-for-bipolar-patients-assessed-in-the-french-expert-center-network-a-2-year-follow-up-observational-study-fondamental-advanced-centers-of-expertise-for-bipolar-disorder-face-bd
#15
Chantal Henry, Ophelia Godin, Philippe Courtet, Jean-Michel Azorin, Sébastien Gard, Frank Bellivier, Mircea Polosan, Jean-Pierre Kahn, Paul Roux, Valerie Aubin, Dominique Costagliola, Marion Leboyer, Bruno Etain
OBJECTIVE: A new health care system for patients with bipolar disorders was established in France under the auspices of Fondation FondaMental, based on thorough clinical assessment of patients and on close collaborations between expert centers and referring practitioners. We report the results of outcomes after 2 years of observational follow-up of adult patients assessed within the network. METHOD: A total of 984 patients were included in the study. We compared several parameters (e...
September 12, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28944523/a-new-method-for-analysing-transition-to-psychosis-joint-modelling-of-time-to-event-outcome-with-time-dependent-predictors
#16
Hok Pan Yuen, Andrew Mackinnon, Barnaby Nelson
An active area in psychosis research is the identification of predictors of transition to a psychotic state among those who are assessed as being at high risk of psychosis. Many of the potential predictors are time dependent in the sense that they may change over time and are measured at a number of assessment time points. Examples are various psychopathological measures such as negative symptoms, positive symptoms, depression, and anxiety. Most research in transition to psychosis has not made use of the dynamic nature of these measures, probably because suitable statistical methods and software have not been easily available...
September 24, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28944461/hearing-aids-for-mild-to-moderate-hearing-loss-in-adults
#17
REVIEW
Melanie A Ferguson, Pádraig T Kitterick, Lee Yee Chong, Mark Edmondson-Jones, Fiona Barker, Derek J Hoare
BACKGROUND: The main clinical intervention for mild to moderate hearing loss is the provision of hearing aids. These are routinely offered and fitted to those who seek help for hearing difficulties. By amplifying and improving access to sounds, and speech sounds in particular, the aim of hearing aid use is to reduce the negative consequences of hearing loss and improve participation in everyday life. OBJECTIVES: To evaluate the effects of hearing aids for mild to moderate hearing loss in adults...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944453/personalised-digital-interventions-for-reducing-hazardous-and-harmful-alcohol-consumption-in-community-dwelling-populations
#18
REVIEW
Eileen Fs Kaner, Fiona R Beyer, Claire Garnett, David Crane, Jamie Brown, Colin Muirhead, James Redmore, Amy O'Donnell, James J Newham, Frank de Vocht, Matthew Hickman, Heather Brown, Gregory Maniatopoulos, Susan Michie
BACKGROUND: Excessive alcohol use contributes significantly to physical and psychological illness, injury and death, and a wide array of social harm in all age groups. A proven strategy for reducing excessive alcohol consumption levels is to offer a brief conversation-based intervention in primary care settings, but more recent technological innovations have enabled people to interact directly via computer, mobile device or smartphone with digital interventions designed to address problem alcohol consumption...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944413/longer-term-baerveldt-to-trabectome-glaucoma-surgery-comparison-using-propensity-score-matching
#19
Tigran Kostanyan, Tarek Shazly, Kevin B Kaplowitz, Steven Z Wang, Sushma Kola, Eric N Brown, Nils A Loewen
PURPOSE: To apply propensity score matching to compare Baerveldt glaucoma drainage implant (BGI) to Trabectome-mediated ab interno trabeculectomy (AIT). Recent data suggests that AIT can produce results similar to BGI which is traditionally reserved for more severe glaucoma. METHODS: BGI and AIT patients with at least 1 year of follow-up were included. The primary outcome measures were intraocular pressure (IOP), number of glaucoma medications, and a Glaucoma Index (GI) score...
September 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28944378/treatment-of-single-and-multiple-miller-class-i-and-iii-gingival-recessions-at-crown-restored-teeth-in-maxillary-esthetic-areas
#20
Anton Sculean, Raluca Cosgarea, Christos Katsaros, Nicole Birgit Arweiler, Richard John Miron, Herbert Deppe
OBJECTIVE: To clinically evaluate the outcomes following surgical coverage of single and multiple Miller Class I and III gingival recessions at crown-restored teeth in the esthetic area by means of the modified coronally advanced tunnel (MCAT). METHOD AND MATERIALS: Eight systemically healthy patients (5 females) with a total of 23 single or multiple maxillary Miller Class I or III gingival recessions were consecutively treated with MCAT in conjunction with a subepithelial connective tissue graft (SCTG)...
September 22, 2017: Quintessence International
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