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Hypercoagulability predictors

Mi Ji Lee, Jong-Won Chung, Myung-Ju Ahn, Seonwoo Kim, Jin Myoung Seok, Hye Min Jang, Gyeong-Moon Kim, Chin-Sang Chung, Kwang Ho Lee, Oh Young Bang
BACKGROUND AND PURPOSE: Patients with active cancer are at an increased risk for stroke. Hypercoagulability plays an important role in cancer-related stroke. We aimed to test whether 1) hypercoagulability is a predictor of survival, and 2) correction of the hypercoagulable state leads to better survival in patients with stroke and active cancer. METHODS: We recruited consecutive patients with acute ischemic stroke and active systemic cancer between January 2006 and July 2015...
January 2017: Journal of Stroke
Zhikun Liu, Haijun Guo, Feng Gao, Qiaonan Shan, Jie Li, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng
AIM: Plasma fibrinogen and D-dimer have been reported to predict survival in several types of malignancies. The aim of this study is to investigate their predictive value in patients with hepatocellular carcinoma (HCC). METHODS: We retrospectively analyzed plasma fibrinogen and D-dimer levels from 252 subjects: control (n = 20), hepatitis (n = 20), cirrhosis (n = 20), and HCC (n = 192) subjects. The clinical involvement and prognostic value of fibrinogen and D-dimer was analyzed in HCC subjects...
December 3, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Archana Hinduja, Kaustubh Limaye, Rahul Ravilla, Appalnaidu Sasapu, Xenofon Papanikolaou, Lai Wei, Michel Torbey, Sarah Waheed
OBJECTIVES: Patients with multiple myeloma (MM) are at increased risk of arterial thrombosis. Our aim was to determine the risk factors, mechanisms and outcome of strokes in these patients. METHODS: We conducted a retrospective matched case-control study from our database of MM patients enrolled in Total Therapy (TT) 2, TT3a and TT3b protocols who developed a vascular event (transient ischemic attack, ischemic stroke, or intracerebral hemorrhage) from October 1998 to January 2014...
2016: PloS One
Giulia Malaguarnera, Vito Emanuele Catania, Antonio Francaviglia, Michele Malaguarnera, Filippo Drago, Massimo Motta, Saverio Latteri
BACKGROUND: The mechanism for hypercoagulability in malignancy is not entirely understood. Although several studies report contrasting finding about the link between elevated plasma levels of the lipoprotein(a) [Lp(a)] and the possible recurrence of venous thromboembolism, we perform a study to evaluate the impact of the Lp(a) in the development of portal vein thromboembolism (PVT) in patients with HCC. METHODS: We compared 44 PVT patients with 50 healthy subjects and 50 HCC patients...
November 7, 2016: Aging Clinical and Experimental Research
K-W Nam, C K Kim, T J Kim, S J An, A M Demchuk, Y Kim, S Jung, M-K Han, S-B Ko, B-W Yoon
BACKGROUND AND PURPOSE: The occurrence of stroke in cancer patients is caused by conventional vascular risk factors and cancer-specific mechanisms. However, cryptogenic stroke in patients with cancer was considered to be more related to cancer-specific hypercoagulability. In this study, we investigated the potential of the D-dimer level to serve as a predictor of early neurologic deterioration (END) in cryptogenic stroke patients with active cancer. METHODS: We recruited 109 cryptogenic stroke patients with active cancer within 72 h of symptom onset...
January 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Po-Chi Hsu, Yu-Chuen Huang, John Y Chiang, Hen-Hong Chang, Pei-Yung Liao, Lun-Chien Lo
BACKGROUND: Diabetes mellitus (DM) is a hypercoagulable state and is associated with highly increased risk of vascular complications. In the theory of traditional Chinese medicine (TCM), these vascular complications are classified as blood stasis. Diagnosis of the tongue plays an important role in TCM; a bluish tongue, petechiae, and engorged sublingual collateral vessels are manifestations of blood stasis. This study aimed to characterize the tongue manifestations of blood stasis and derive a relationship between blood stasis and vascular disorders in patients with type 2 DM...
August 27, 2016: BMC Complementary and Alternative Medicine
William R Stetler, Julius Griauzde, Yamaan Saadeh, Thomas J Wilson, Wajd N Al-Holou, Neeraj Chaudhary, B Gregory Thompson, Aditya S Pandey, Joseph J Gemmete
INTRODUCTION: Patients with an unruptured intracranial aneurysm treated with coil embolization are routinely admitted to the intensive care unit (ICU) after the procedure; however, this practice is questionable. The purpose of this study was to determine if routine admission to the ICU is necessary for patients undergoing coil embolization of an unruptured intracranial aneurysm. METHODS: We conducted a retrospective cohort study of all patients undergoing elective endovascular treatment of an unruptured intracranial aneurysm between 2005 and 2012 at our institution...
July 5, 2016: Journal of Neurointerventional Surgery
Jihyun Yang, Jun Yong Lee, Young Ju Na, Sung Yoon Lim, Myung-Gyu Kim, Sang-Kyung Jo, Wonyong Cho
BACKGROUND: Renal infarction (RI) is an uncommon disease that is difficult to diagnose. As little is known about clinical characteristics of this disease, we investigated its underlying risk factors and outcomes. METHODS: We performed a retrospective single-center study of 89 patients newly diagnosed with acute RI between January 2002 and March 2015 using imaging modalities. Clinical features, possible etiologies, and long-term renal outcome data were reviewed. RESULTS: The patients' mean age was 63...
June 2016: Kidney Research and Clinical Practice
Georgios N Kalambokis, Aikaterini Oikonomou, Leonidas Christou, Nikolaos I Kolaitis, Epameinondas V Tsianos, Dimitrios Christodoulou, Gerasimos Baltayiannis
BACKGROUND & AIMS: Several lines of evidence suggest that the hemostatic disorders of cirrhosis may have a significant clinical impact. We investigated the independent predictive value of components of the hemostatic system on the occurrence of ascites, variceal bleeding (VB), and survival. METHODS: One hundred and two patients with thrombocytopenia (Child-Pugh class A/B/C: 34/34/34) were enrolled. Platelet counts, factors (F) II, V, VII, and VIII, antithrombin, protein C (PC), FVIII-to-PC ratio as an index of procoagulant imbalance, von Willebrand factor antigen (vWF-Ag), and model for end-stage liver disease (MELD) were evaluated...
November 2016: Journal of Hepatology
I Vasilenko, E Vlasova, V Metelin, A Balkanov, O Bichenkov
INTRODUCTION: Close correlation between oncologic diseases and blood coagulation disturbances dictates a necessity of prognosis of the main disease course and contemporary prevention of the thrombotic complications revealed. For this purpose, the global test for the hemostasis system assessment was used to reveal bleeding and thrombogenesis risks - "Thrombodynamics" (TD) allowing analysis in the real time of the thrombogenesis parameters in conditions the most resembling the natural functioning of the blood coagulation system...
April 2016: Thrombosis Research
Z K Tan, P Casipit, N S Pandit
INTRODUCTION: Literature has reported tumour thrombus along the inferior vena cava as a result of underlying renal cell carcinoma (RCC) or along the portal vein from hepatocellular carcinoma (HCC). However, tumor thrombus is a rather uncommon complication of a metastatic tumour deposit in the superior vena cava in lung adenocarcinoma. Detection of tumour thrombus at the time of cancer diagnosis is a significant predictor of morbidity and mortality. Unlike RCC with vena caval extension where surgical resection provides meaningful long term survival, lung adenocarcinoma with vena cava involvement has a very dismal outcome...
April 2016: Thrombosis Research
Javad Parvizi, Ronald Huang, Maryam Rezapoor, Behrad Bagheri, Mitchell G Maltenfort
BACKGROUND: Venous thromboembolism (VTE) after total joint arthroplasty (TJA) is a potentially fatal complication. Currently, a standard protocol for postoperative VTE prophylaxis is used that makes little distinction between patients at varying risks of VTE. We sought to develop a simple scoring system identifying patients at higher risk for VTE in whom more potent anticoagulation may need to be administered. METHODS: Utilizing the National Inpatient Sample data, 1,721,806 patients undergoing TJA were identified, among whom 15,775 (0...
September 2016: Journal of Arthroplasty
Sharon Orbach-Zinger, Leonid A Eidelman, Alexander Lutsker, Galia Oron, Benjamin Fisch, Avi Ben-Haroush
OBJECTIVES: In vitro fertilization (IVF) induced elevated estrogen levels are associated with a hypercoagulable state. Thromboelastogram (TEG) is a point of care whole blood hemostasis analyzer which measures functionality of clotting parameters. Our study's objective was to examine the influence of the early and late follicular phase of an IVF simulation cycle on coagulation parameters as measured by TEG and to evaluate the influence of age on coagulation parameters. STUDY DESIGN: In a single center, prospective, observational trial, 46 women undergoing IVF therapy were studied...
June 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Yasufumi Gon, Shuhei Okazaki, Yasukazu Terasaki, Tsutomu Sasaki, Toshiki Yoshimine, Manabu Sakaguchi, Hideki Mochizuki
OBJECTIVE: To clarify the characteristics of cryptogenic stroke in patients with active cancer. METHODS: Patients with or without cancer diagnosed with acute ischemic stroke between January 2006 and February 2015 were extracted from a prospectively collected stroke database of Osaka University Hospital. Patients were categorized according to the presence of active cancer and known stroke mechanisms. RESULTS: Among 1191 patients with acute ischemic stroke, 145 (12%) had active cancer...
April 2016: Annals of Clinical and Translational Neurology
Yong-Won Shin, Soon-Tae Lee, Keun-Hwa Jung, Do-Yong Kim, Chul-Kee Park, Tae Min Kim, Seung Hong Choi, Kon Chu, Sang Kun Lee
Patients with active cancer experience ischemic stroke via cryptogenic mechanisms, with cancer-associated hypercoagulability being considered a major contributor to such strokes. Despite the remarkably shortened survival of these patients, the clinical predictors of survival are poorly understood. We determined the clinical factors including D-dimer levels serving as the predictors of overall survival in these patients. Retrospective study was conducted on cancer patients who visited our hospital for acute ischemic stroke with cryptogenic mechanisms from April 2012 through November 2014...
June 2016: Journal of Neuro-oncology
Ping Gong, Sheng-Hua Yang, Sha Li, Song-Hui Luo, Rui-Xiang Zeng, Yan Zhang, Yuan-Lin Guo, Cheng-Gang Zhu, Rui-Xia Xu, Jian-Jun Li
Increased d-dimer is indicative of a hypercoagulable state and found to be associated with acute coronary syndromes. The present study aimed to evaluate whether plasma d-dimer levels could predict subsequent major clinical events in patients with coronary artery disease (CAD). First, 2209 angiographic-proven patients with CAD were consecutively enrolled. Then, all patients were subjected to follow up for an average of 18 months (ranged from 14 to 1037 days). The relationships of the plasma d-dimer with the severity of CAD and future clinical outcomes were evaluated...
October 2016: Clinical and Applied Thrombosis/hemostasis
Joan R Williams, Milton T M Little, Patricia A Kramer, Stephen K Benirschke
OBJECTIVES: This study examined the incidence and risk factors of preoperative deep vein thrombosis (DVT) in patients presenting to an outpatient setting with an isolated calcaneal fracture. DESIGN: Retrospective chart review. SETTING: All patients included in the study presented to the treating surgeon at a Level I trauma center with isolated calcaneal fractures as an outpatient between 2005 and 2013. METHODS: These patients were either referred from outside hospitals, had been evaluated in the emergency department initially and presented for definitive care, or presented initially to the outpatient clinic...
July 2016: Journal of Orthopaedic Trauma
Eric W Sankey, Joseph Lopez, Shuting Susan Zhong, Harlyn Susarla, Ignacio Jusué-Torres, Jason Liauw, Judy Huang, Michael Streiff, Henry Brem, Chad R Gordon
BACKGROUND: Despite advancements in materials and techniques used for cranial reconstruction, complication rates following reconstructive cranioplasty remain significant. METHODS: In this study, the authors assessed the association of perioperative anticoagulation use and/or a hypercoagulable state with minor (i.e., not requiring surgical intervention) and major (i.e., surgical intervention required) complications after reconstructive cranioplasty for large skull defects...
February 2016: Plastic and Reconstructive Surgery
Camille Ettelaie, Mary Ew Collier, Sophie Featherby, Naima E Benelhaj, John Greenman, Anthony Maraveyas
BACKGROUND: Despite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear. METHODS: In this study the upregulation of TF release upon activation of various cancer cell lines, and the correlation with TF and PAR2 expression and/or activity was examined. Microvesicle release was induced by PAR2 activation in seventeen cell lines and released microvesicle density, microvesicle-associated TF activity, and phoshpatidylserine-mediated activity were measured...
2016: Thrombosis Journal
Janette Bester, Mia-Jeanne van Rooy, Sthembile Mbotwe, Wiebren Duim, Etheresia Pretorius
Transient ischemic attack (TIA) is an important predictor of future ischemic events, including stroke. Due to the typically brief period of neurologic dysfunction, patients often overlook the importance of reporting a TIA. We have recently shown that platelet activation plays an important role in TIA pathology. In a similar vein, smoking is associated with a hypercoagulable state and is also one of the important risk factors for stroke. Here we present an interesting case where a 61-year-old male, with hypercholesterolemia, and a previous heart valve replacement, developed a TIA 5 months after he started smoking...
2016: Ultrastructural Pathology
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