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Connie Y Chang, Daniel I Rosenthal, Deborah M Mitchell, Atsuhiko Handa, Susan V Kattapuram, Ambrose J Huang
Metabolic bone diseases are a diverse group of diseases that result in abnormalities of (a) bone mass, (b) structure mineral homeostasis, (c) bone turnover, or (d) growth. Osteoporosis, the most common metabolic bone disease, results in generalized loss of bone mass and deterioration in the bone microarchitecture. Impaired chondrocyte development and failure to mineralize growth plate cartilage in rickets lead to widened growth plates and frayed metaphyses at sites of greatest growth. Osteomalacia is the result of impaired mineralization of newly formed osteoid, which leads to characteristic Looser zones...
October 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Farrukh Abbas, Le Dung Ha, Richard Sterns, Laura von Doenhoff
No abstract text is available yet for this article.
October 2016: Circulation. Heart Failure
Christine Chan, Sarah Eby
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Melissa A Moser, Ock K Chun
Vitamin C is a powerful dietary antioxidant that has received considerable attention in the literature related to its possible role in heart health. Although classical vitamin C deficiency, marked by scurvy, is rare in most parts of the world, some research has shown variable heart disease risks depending on plasma vitamin C concentration, even within the normal range. Furthermore, other studies have suggested possible heart-related benefits to vitamin C taken in doses beyond the minimal amounts required to prevent classically defined deficiency...
2016: International Journal of Molecular Sciences
Jonathan Lamb
No abstract text is available yet for this article.
August 8, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
R André, A Gabrielli, E Laffitte, O Kherad
INTRODUCTION: Scurvy, or "Barlow's disease", is a widely described disease involving cutaneous and mucosal lesions resulting from vitamin C deficiency. Herein, we report a case of scurvy in a 48-year-old woman that was unusual in its atypical cutaneous-mucosal presentation as well as its association with anorexia nervosa. PATIENTS AND METHODS: A 48-year-old woman treated for depression for several years was admitted to hospital for her impaired general state of health...
August 5, 2016: Annales de Dermatologie et de Vénéréologie
Megumi Seya, Atsuhiko Handa, Daisuke Hasegawa, Toshihiro Matsui, Taiki Nozaki
No abstract text is available yet for this article.
October 2016: Journal of Pediatrics
Danielle Mintsoulis, Nataliya Milman, Simone Fahim
IMPORTANCE: Scurvy remains prevalent in certain populations, including addicts, people of low socioeconomic status, and the severely malnourished. It classically presents as follicular hyperkeratosis and perifollicular hemorrhage of the lower extremities, as well as bleeding in other areas such as the gingiva and joints. This case presentation and literature review highlights the common pathophysiological findings associated with scurvy and current methods of diagnosis and treatment. OBSERVATION: The patient described in this case presented with sudden oligoarthritis and purpura of the lower extremities...
July 14, 2016: Journal of Cutaneous Medicine and Surgery
P Aubry, B-A Gaüzère
In 1498, the Portuguese crossed the Cape of Good Hope. It was not until the period of 1633 and 1666, dates of the founding, respectively, of the Compagnie de l'Orient and the Compagnie des Indes orientales, that the way was definitively opened for trade between France and India. Because so many sailors developed scurvy after voyages that lasted 4 to 5 months, the French settled on Bourbon Island (Réunion) and Ile de France (Mauritius), to provide them with medical care. Created in 1689 by Louis XIV, the Navy Health Service was responsible for health in the colonies until it was replaced in 1890 by the Colonial Health Service...
May 1, 2016: Médecine et Santé Tropicales
James D Vasta, Ronald T Raines
Collagen is the most abundant protein in animals. The posttranslational hydroxylation of proline residues in collagen contributes greatly to its conformational stability. Deficient hydroxylation is associated with a variety of disease states, including scurvy. The hydroxylation of proline residues in collagen is catalyzed by an Fe(II)- and α-ketoglutarate-dependent dioxygenase, collagen prolyl 4-hydroxylase (CP4H). CP4H has long been known to suffer oxidative inactivation during catalysis, and the cofactor ascorbate (vitamin C) is required to reactivate the enzyme by reducing its iron center from Fe(III) to Fe(II)...
June 14, 2016: Biochemistry
Alexander E Domingo, Christopher B Ruser, Brittany Simone, Daniel G Federman
Bleeding disorders are common. In addition to thinking about disorders relating to abnormal platelets or clotting factors, clinicians should consider disorders of vascular integrity in their differential diagnosis. We present a patient with atypical, spontaneous bleeding that was due to scurvy, an often overlooked cause. Clinicians should be aware of the risk factors for the development of scurvy, such as poor dietary intake, male gender, smoking, alcohol abuse, as well as its classic manifestations, including gingival bleeding, spontaneous bruising, corkscrew hairs, and poor wound healing, A heightened awareness may lead to earlier diagnosis and treatment...
August 2016: Postgraduate Medicine
Kulnipa Kittisakmontri, Napatsayod Swangtrakul, Wiralpatch Padungmaneesub, Pimlak Charoenkwan
Patients with chronic kidney disease (CKD) or end-stage renal disease are at risk for vitamin C deficiency and scurvy due to diet restriction, increased urinary loss of the water-soluble vitamin C with diuretics, and in case of patients who are on dialysis, through dialysates. The condition may be overlooked as the clinical manifestation of scurvy may be subtle, and some presentations may mimic clinical signs in CKD. We reported a case of scurvy presenting with gingival bleeding and blood dialysate in a 6-year-old girl with end-stage renal disease who was on continuous ambulatory peritoneal dialysis...
April 22, 2016: Journal of Renal Nutrition
Lauren E Amos, Shannon L Carpenter, Mark F Hoeltzel
Scurvy results from a dietary deficiency of vitamin C (ascorbic acid) and is rarely thought of in modern day medicine. It now almost always occurs in pediatric patients with behavioral diagnoses, nutritionally restricted diets, and food allergies. Symptoms of scurvy include ecchymoses, bleeding gums, and arthralgias. Here, we present a 17-year-old male with autism spectrum disorder and a diet severely deficient in ascorbic acid due to textural aversion and food preferences. He presented with recurrent arthritis, hemarthrosis, bruising, and anemia...
July 2016: Pediatric Blood & Cancer
Tarek Shaath, Ryan Fischer, Megan Goeser, Anand Rajpara, Daniel Aires
Scurvy results from a deficiency of vitamin C, a nutrient otherwise known as ascorbic acid. Today, scurvy is rare yet emerges in select patients. The patient reported herein developed scurvy secondary to deliberate avoidance of vitamin C-rich foods. Classic cutaneous manifestations of scurvy include follicular hyperkeratosis and perifollicular hemorrhage encompassing coiled "corkscrew" hairs and hairs bent into "swan-neck" deformities. Ecchymoses, purpura, and petechiae are also characteristically prominent...
January 2016: Dermatology Online Journal
J Loureiro-Amigo, M López-Corbeto
No abstract text is available yet for this article.
August 2016: Revista Clínica Española
S J Padayatty, M Levine
Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts as a cofactor for fifteen mammalian enzymes. Two sodium-dependent transporters are specific for ascorbic acid, and its oxidation product dehydroascorbic acid is transported by glucose transporters. Ascorbic acid is differentially accumulated by most tissues and body fluids. Plasma and tissue vitamin C concentrations are dependent on amount consumed, bioavailability, renal excretion, and utilization...
September 2016: Oral Diseases
Isidro Vitoria, Berta López, Jacinto Gómez, Carolina Torres, María Guasp, Inmaculada Calvo, Jaime Dalmau
Scurvy is a rare disease in developed countries. Risk groups include children with restricted diets, mainly patients who are autistic or have cerebral palsy. Furthermore, consumption of plant-based beverages has increased in recent years, especially in developed countries. When plant-based beverages are the exclusive diet in the first year of life and not consumed as a supplement to formula or breastfeeding, it can result in severe nutritional problems. We report a case of scurvy after exclusive intake of almond beverages and almond flour from 2...
February 2016: Pediatrics
K Hofheinz, I Ganzleben, S Schliep, J Wacker, G Schett, B Manger
BACKGROUND: In December 2014 a patient presented to our clinic with the clinical symptoms of vasculitis. However, treatment with glucocorticoids did not lead to any improvement; therefore, the differential diagnostics were extended to other indications and ultimately led to the diagnosis of scurvy. OBJECTIVE: This article describes the clinical picture of scurvy and its relationship to rheumatic diseases based on a clinical case and additional information from the literature...
March 2016: Zeitschrift Für Rheumatologie
Nina S Ma, Cynthia Thompson, Sharon Weston
Scurvy was diagnosed in seven children at Boston Children's Hospital. All of the children had a developmental disorder and autism was the most common. They had a long-standing history of food selectivity with diets devoid of fruits and vegetables, and none of the children were supplemented with a multivitamin. They presented with limp, and an elaborate panel of tests and procedures were undertaken before the diagnosis of scurvy was made. Treatment with vitamin C led to rapid recovery of symptoms. This report emphasizes the importance of considering nutritional causes of musculoskeletal symptoms in children with autism and restrictive diets...
April 2016: Journal of Autism and Developmental Disorders
Chanika Angsanuntsukh, Kulapat Chulsomlee, Anan Taracheewin, Suphaneewan Jaovisidha, Thira Woratanarat, Patarawan Woratanarat
This case report aimed to describe the clinical presentation, treatments and prognosis of a child who had scurvy and traumatic injury of the left thigh. A 30-month-old boy had presented with left hip pain two weeks after falling down on the floor while walking. He developed pain, warmness of the left hip and thigh, and finally was unable to bear weight. He also had a high fever gingival hemorrhage, dental caries, petechiae, positive rolling test and limited range of motion of the left hip. The radiographs revealed Wimberger's ring and Frenkel line as scurvy...
September 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
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