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https://www.readbyqxmd.com/read/27915106/insights-gained-from-ancient-biomolecules-into-past-and-present-tuberculosis-a-personal-perspective
#1
REVIEW
Helen D Donoghue
Ancient and historical tuberculosis (TB) can be recognized by its typical paleopathology in human remains. Using paleomicrobiology, it is possible to detect many more individuals infected with TB but with no visible lesions. Due to advances in molecular analysis over the past two decades, it is clear that TB was widespread in humans from the Neolithic period until the present day. Past human populations were associated with different lineages of the Mycobacterium tuberculosis (MTB) complex, thereby elucidating early human migrations...
November 30, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27859562/vitamin%C3%A2-c-deficiency-and-diabetes-mellitus-easily-missed
#2
D J Christie-David, J E Gunton
Scurvy and vitamin C deficiency are usually considered to be of only historical interest. Interestingly, most animals can synthesize vitamin C, but not humans, higher primates, guinea-pigs and some bats. Deficiency results in the defective formation of collagen and connective tissues; symptoms of deficiency may include bruising, bleeding gums, petechiae, arthralgia and impaired wound healing [1,2]. This article is protected by copyright. All rights reserved.
November 18, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27851280/1645-cardiac-arrest-and-pulmonary-hypertension-in-scurvy-a-case-report
#3
Terry Dean, Neeru Kaushik, Sharon Williams, Jeffrey Fineman, Paul Kim
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27836062/back-to-the-future-1753-vitamin-c-remediates-scurvy-2016-folinic-acid-does-the-same-for-mthfd1-scid-with-the-help-of-exome-sequencing
#4
EDITORIAL
Roger H Kobayashi
No abstract text is available yet for this article.
November 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27795777/systematic-reviews-in-context-highlighting-systematic-reviews-relevant-to-africa-in-the-pan-african-medical-journal
#5
Charles Shey Wiysonge, Raoul Kamadjeu, Landry Tsague
Health research serves to answer questions concerning health and to accumulate facts (evidence) required to guide healthcare policy and practice. However, research designs vary and different types of healthcare questions are best answered by different study designs. For example, qualitative studies are best suited for answering questions about experiences and meaning; cross-sectional studies for questions concerning prevalence; cohort studies for questions regarding incidence and prognosis; and randomised controlled trials for questions on prevention and treatment...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27778040/modern-american-scurvy-experience-with-vitamin-c-deficiency-at-a-large-children-s-hospital
#6
Farahnaz Golriz, Lane F Donnelly, Sridevi Devaraj, Raj Krishnamurthy
BACKGROUND: Until recently scurvy has been viewed in developed countries as a disease of the past. More recently there have been reports of case series of children with scurvy who have had a delayed diagnosis after an extensive diagnostic workup that included imaging. Most of these children have had underlying neurologic conditions such as autism. OBJECTIVE: To review the medical records of children diagnosed with vitamin C (ascorbic acid) deficiency based on serum ascorbic acid levels at a large pediatric health care system, to determine imaging findings and utility of imaging in management, and to identify at-risk pediatric populations...
October 24, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27726750/imaging-findings-of-metabolic-bone-disease
#7
Connie Y Chang, Daniel I Rosenthal, Deborah M Mitchell, Atsuhiko Handa, Susan V Kattapuram, Ambrose J Huang
Metabolic bone diseases are a diverse group of diseases that result in abnormalities of (a) bone mass, (b) structure mineral homeostasis, (c) bone turnover, or (d) growth. Osteoporosis, the most common metabolic bone disease, results in generalized loss of bone mass and deterioration in the bone microarchitecture. Impaired chondrocyte development and failure to mineralize growth plate cartilage in rickets lead to widened growth plates and frayed metaphyses at sites of greatest growth. Osteomalacia is the result of impaired mineralization of newly formed osteoid, which leads to characteristic Looser zones...
October 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27682441/reversible-right-heart-failure-in-scurvy-rediscovery-of-an-old-observation
#8
Farrukh Abbas, Le Dung Ha, Richard Sterns, Laura von Doenhoff
No abstract text is available yet for this article.
October 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27673049/poster-293-pain-and-weakness-due-to-scurvy-and-other-vitamin-deficiencies-a-case-report
#9
Christine Chan, Sarah Eby
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27529239/vitamin-c-and-heart-health-a-review-based-on-findings-from-epidemiologic-studies
#10
REVIEW
Melissa A Moser, Ock K Chun
Vitamin C is a powerful dietary antioxidant that has received considerable attention in the literature related to its possible role in heart health. Although classical vitamin C deficiency, marked by scurvy, is rare in most parts of the world, some research has shown variable heart disease risks depending on plasma vitamin C concentration, even within the normal range. Furthermore, other studies have suggested possible heart-related benefits to vitamin C taken in doses beyond the minimal amounts required to prevent classically defined deficiency...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27503863/scurvy-and-the-enhancement-of-the-senses
#11
Jonathan Lamb
No abstract text is available yet for this article.
August 8, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27502755/-atypical-scurvy-associated-with-anorexia-nervosa
#12
R André, A Gabrielli, E Laffitte, O Kherad
INTRODUCTION: Scurvy, or "Barlow's disease", is a widely described disease involving cutaneous and mucosal lesions resulting from vitamin C deficiency. Herein, we report a case of scurvy in a 48-year-old woman that was unusual in its atypical cutaneous-mucosal presentation as well as its association with anorexia nervosa. PATIENTS AND METHODS: A 48-year-old woman treated for depression for several years was admitted to hospital for her impaired general state of health...
August 5, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27426835/scurvy-from-a-selective-diet-in-children-with-developmental-delay
#13
Megumi Seya, Atsuhiko Handa, Daisuke Hasegawa, Toshihiro Matsui, Taiki Nozaki
No abstract text is available yet for this article.
October 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27416817/a-case-of-scurvy-uncommon-disease-presenting-as-panniculitis-purpura-and-oligoarthritis
#14
Danielle Mintsoulis, Nataliya Milman, Simone Fahim
IMPORTANCE: Scurvy remains prevalent in certain populations, including addicts, people of low socioeconomic status, and the severely malnourished. It classically presents as follicular hyperkeratosis and perifollicular hemorrhage of the lower extremities, as well as bleeding in other areas such as the gingiva and joints. This case presentation and literature review highlights the common pathophysiological findings associated with scurvy and current methods of diagnosis and treatment. OBSERVATION: The patient described in this case presented with sudden oligoarthritis and purpura of the lower extremities...
July 14, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27412971/history-of-health-in-the-indian-ocean-care-prevention-teaching-and-research-from-the-17-th-to-the-mid-20th-century
#15
P Aubry, B-A Gaüzère
In 1498, the Portuguese crossed the Cape of Good Hope. It was not until the period of 1633 and 1666, dates of the founding, respectively, of the Compagnie de l'Orient and the Compagnie des Indes orientales, that the way was definitively opened for trade between France and India. Because so many sailors developed scurvy after voyages that lasted 4 to 5 months, the French settled on Bourbon Island (Réunion) and Ile de France (Mauritius), to provide them with medical care. Created in 1689 by Louis XIV, the Navy Health Service was responsible for health in the colonies until it was replaced in 1890 by the Colonial Health Service...
May 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/27183028/human-collagen-prolyl-4-hydroxylase-is-activated-by-ligands-for-its-iron-center
#16
James D Vasta, Ronald T Raines
Collagen is the most abundant protein in animals. The posttranslational hydroxylation of proline residues in collagen contributes greatly to its conformational stability. Deficient hydroxylation is associated with a variety of disease states, including scurvy. The hydroxylation of proline residues in collagen is catalyzed by an Fe(II)- and α-ketoglutarate-dependent dioxygenase, collagen prolyl 4-hydroxylase (CP4H). CP4H has long been known to suffer oxidative inactivation during catalysis, and the cofactor ascorbate (vitamin C) is required to reactivate the enzyme by reducing its iron center from Fe(III) to Fe(II)...
June 14, 2016: Biochemistry
https://www.readbyqxmd.com/read/27177185/now-you-see-c-it
#17
Alexander E Domingo, Christopher B Ruser, Brittany Simone, Daniel G Federman
Bleeding disorders are common. In addition to thinking about disorders relating to abnormal platelets or clotting factors, clinicians should consider disorders of vascular integrity in their differential diagnosis. We present a patient with atypical, spontaneous bleeding that was due to scurvy, an often overlooked cause. Clinicians should be aware of the risk factors for the development of scurvy, such as poor dietary intake, male gender, smoking, alcohol abuse, as well as its classic manifestations, including gingival bleeding, spontaneous bruising, corkscrew hairs, and poor wound healing, A heightened awareness may lead to earlier diagnosis and treatment...
August 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27118080/gingival-bleeding-and-bloody-dialysate-a-case-report-of-scurvy-in-a-child-with-end-stage-renal-disease-receiving-peritoneal-dialysis
#18
Kulnipa Kittisakmontri, Napatsayod Swangtrakul, Wiralpatch Padungmaneesub, Pimlak Charoenkwan
Patients with chronic kidney disease (CKD) or end-stage renal disease are at risk for vitamin C deficiency and scurvy due to diet restriction, increased urinary loss of the water-soluble vitamin C with diuretics, and in case of patients who are on dialysis, through dialysates. The condition may be overlooked as the clinical manifestation of scurvy may be subtle, and some presentations may mimic clinical signs in CKD. We reported a case of scurvy presenting with gingival bleeding and blood dialysate in a 6-year-old girl with end-stage renal disease who was on continuous ambulatory peritoneal dialysis...
April 22, 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/27062477/lost-at-sea-in-search-of-a-diagnosis-a-case-of-unexplained-bleeding
#19
Lauren E Amos, Shannon L Carpenter, Mark F Hoeltzel
Scurvy results from a dietary deficiency of vitamin C (ascorbic acid) and is rarely thought of in modern day medicine. It now almost always occurs in pediatric patients with behavioral diagnoses, nutritionally restricted diets, and food allergies. Symptoms of scurvy include ecchymoses, bleeding gums, and arthralgias. Here, we present a 17-year-old male with autism spectrum disorder and a diet severely deficient in ascorbic acid due to textural aversion and food preferences. He presented with recurrent arthritis, hemarthrosis, bruising, and anemia...
July 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26990475/scurvy-in-the-present-times-vitamin-c-allergy-leading-to-strict-fast-food-diet
#20
Tarek Shaath, Ryan Fischer, Megan Goeser, Anand Rajpara, Daniel Aires
Scurvy results from a deficiency of vitamin C, a nutrient otherwise known as ascorbic acid. Today, scurvy is rare yet emerges in select patients. The patient reported herein developed scurvy secondary to deliberate avoidance of vitamin C-rich foods. Classic cutaneous manifestations of scurvy include follicular hyperkeratosis and perifollicular hemorrhage encompassing coiled "corkscrew" hairs and hairs bent into "swan-neck" deformities. Ecchymoses, purpura, and petechiae are also characteristically prominent...
January 2016: Dermatology Online Journal
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