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https://www.readbyqxmd.com/read/28894047/the-role-of-vitamin-c-in-epigenetic-regulation
#1
Jolanta Guz, Ryszard Oliński
Vitamin C (L-ascorbic acid) is a micronutrient best known for its anti-scurvy activity in humans. Vitamin C is involved in many biological processes involving enzymatic reactions that are catalyzed by members of dioxygenases which use Fe(II) and 2-oxoglutarate as a co-substrate.The article reviews recent data that suggest the involvement of ascorbate in dioxygenases catalyzed chromatin and DNA modifications which thereby contribute to epigenetic regulation. Concerning chromatin modification, the dioxygenases are involved in distinct demethylation reactions with varying specificity for the position of the lysine on the target histone...
August 24, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28891493/infantile-scurvy
#2
Simrat Kaur, Jatinder S Goraya
No abstract text is available yet for this article.
August 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28888398/basilar-portion-porosity-a-pathological-lesion-possibly-associated-with-infantile-scurvy
#3
Joanna Moore, Hannah E C Koon
Recent analysis of the juvenile (≤12 years) human remains from a 19th century site in Wolverhampton, England revealed a relatively high level of nutritional deficiency diseases within the population. Indeed, 41.7% of the 48 juvenile skeletons analysed exhibited a combination of porous and proliferative bone lesions consistent with the pathological alterations associated with nutritional stress. This paper describes a pathological lesion on the inferior surface of the basilar portion of the occipital bone, not previously reported in association with infantile scurvy, but which was exhibited by 90% (N=9) of the 10 scorbutic individuals identified during this study...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28888387/scurvy-at-the-agricultural-transition-in-the-atacama-desert-ca-3600-3200-bp-nutritional-stress-at-the-maternal-foetal-interface
#4
Anne Marie E Snoddy, Siân E Halcrow, Hallie R Buckley, Vivien G Standen, Bernardo T Arriaza
Studies of contemporary populations have demonstrated an association between decreased dietary diversity due to resource scarcity or underutilization and an increase in diseases related to poor micronutrient intake. With a reduction of dietary diversity, it is often the women and children in a population who are the first to suffer the effects of poor micronutrient status. Scurvy, a disease of prolonged vitamin C deficiency, is a micronutrient malnutrition disorder associated with resource scarcity, low dietary diversity, and/or dependence on high carbohydrate staple-foods...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28856210/development-and-implementation-of-an-hplc-ecd-method-for-analysis-of-vitamin-c-in-plasma-using-single-column-and-automatic-alternating-dual-column-regeneration
#5
Zlatuse D Clark, Elizabeth L Frank
OBJECTIVES: Vitamin C (l-ascorbic acid) is a water-soluble micronutrient necessary for human life. Inadequate intake can lead to the fatal disease scurvy. Measurement of vitamin C is used to assess nutritional status and to monitor supplementation. The goal of this study was to develop a chromatographic method for the quantitation of vitamin C in human plasma. DESIGN AND METHODS: Samples were prepared by protein precipitation, addition of internal standard, and reduction with dithiothreitol...
December 1, 2016: Pract Lab Med
https://www.readbyqxmd.com/read/28833652/bateman-purpura-dermatoporosis-a-localized-scurvy-treated-by-topical-vitamin-c-double-blind-randomized-placebo-controlled-clinical-trial
#6
P Humbert, F Fanian, T Lihoreau, A Jeudy, G E Pierard
BACKGROUND: Bateman purpura is characterized by diffuse senile skin atrophy, senile purpura and spontaneous stellar pseudo-cicatrices. Cutaneous changes in the course of aging have been related to lower levels of ascorbic acid into the dermis of elderly people. OBJECTIVE: In the present study, we postulate that senile purpura could be linked to dermal vitamin C deficiency and could be corrected by topical administration of this vitamin. METHODS: A 12-weeks, hemi-member (forearm or leg), randomized double-blind comparative study, was conducted in 18 patients with Bateman purpura aged over than 60 years...
August 17, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28690213/scurvy-an-almost-forgotten-disease
#7
Marta González-Sabín, Eloy Rodríguez-Díaz, Susana Mallo-García, Ivan Astola-Hidalgo
No abstract text is available yet for this article.
July 8, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28606012/scurvy-surprisingly-not-yet-extinct
#8
Žiga Rotar, Ivan Ferkolj, Matija Tomšič, Alojzija Hočevar
No abstract text is available yet for this article.
August 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28449021/scurvy-in-new-zealand-a-forgotten-disease
#9
James Bartley
No abstract text is available yet for this article.
April 28, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28440777/restricted-diet-in-fruits-causes-scurvy-in-a-child-of-7-years-old
#10
Rosmari Vázquez Gomis, Ignacio Izquierdo Fos, Consuelo Vázquez Gomis, José Pastor Rosado
No abstract text is available yet for this article.
February 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28410599/the-role-of-vitamin-c-in-the-treatment-of-pain-new-insights
#11
REVIEW
Anitra C Carr, Cate McCall
The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermore, accumulating evidence indicates that vitamin C administration can exhibit analgesic properties in some clinical conditions. The prevalence of hypovitaminosis C and vitamin C deficiency is high in various patient groups, such as surgical/trauma, infectious diseases and cancer patients. A number of recent clinical studies have shown that vitamin C administration to patients with chronic regional pain syndrome decreases their symptoms...
April 14, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28396889/gingival-bleeding-in-a-patient-with-autism-spectrum-disorder-a-key-finding-leading-to-a-diagnosis-of-scurvy
#12
Adela Planerova, Sherry Philip, Sharon Elad
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that can affect all aspects of life, including nutrition. This case reports a patient with ASD in which gingival bleeding was the key finding that led to a diagnosis of scurvy. The literature review discusses behavioral food aversions in patients with ASD that lead to significant nutritional deficiencies, such as scurvy. Through this case report, the objective is to raise clinical awareness to consider relatively rare diseases in patients with ASD who have atypical feeding patterns...
2017: Quintessence International
https://www.readbyqxmd.com/read/28362181/infantile-scurvy-revealed-by-spontaneous-orbital-hematoma
#13
Aurore Aziz, Fréderic Matonti, Valentine Bautrant, Jean-Marc Foletti, Danièle Denis
No abstract text is available yet for this article.
March 31, 2017: Orbit
https://www.readbyqxmd.com/read/28317301/early-diagnosis-of-scurvy-based-on-radiology-and-dietary-history
#14
Kazuhiro Uda, Masahiro Goto, Ayako Nigo, Tatsuo Kono
No abstract text is available yet for this article.
March 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28286794/gastrointestinal-bleeding-secondary-to-scurvy-in-an-alcoholic-malnourished-cirrhotic-patient
#15
Artur Sérgio Gião Antunes, Bruno Peixe, Horácio Guerreiro
No abstract text is available yet for this article.
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28231513/increasing-ascorbate-levels-in-crops-to-enhance-human-nutrition-and-plant-abiotic-stress-tolerance
#16
REVIEW
Richard C Macknight, William A Laing, Sean M Bulley, Ronan C Broad, Alexander At Johnson, Roger P Hellens
Ascorbate (or vitamin C) is an essential human micronutrient predominantly obtained from plants. In addition to preventing scurvy, it is now known to have broader roles in human health, for example as a cofactor for enzymes involved in epigenetic programming and as regulator of cellular iron uptake. Furthermore, ascorbate is the major antioxidant in plants and underpins many environmentally induced abiotic stress responses. Biotechnological approaches to enhance the ascorbate content of crops therefore have potential to improve both human health and abiotic stress tolerance of crops...
April 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28217165/headband-sign-on-magnetic-resonance-imaging-an-unusual-finding-of-scurvy-in-a-5-year-old-child-described-first-time
#17
Umesh I Patel, Jayendra R Gohil, Alpa N Parekh, Hardik R Chauhan
Scurvy usually presents with tender and painful limbs, swelling of joints, gum bleeding, poor wound healing, and muscle weakness. Here, we report a case of 5-year-old child with global developmental delay who presented with soft swelling of the head over scalp and protrusion of the left eye with extremely irritability. Neuroimaging was suggestive of diffuse extensive soft-tissue swelling involving the entire scalp with large necrotic collections with mild proptosis of the left orbit. It is not mentioned elsewhere, so we are giving name to this magnetic resonance imaging finding as "headband" sign or "turban" sign...
October 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28216897/high-performance-liquid-chromatography-diode-array-detector-method-for-the-simultaneous-determination-of-five-compounds-in-the-pulp-and-seed-of-sea-buckthorn
#18
Lu Zhao, E Wen, Halmuart Upur, Shuge Tian
CONTEXT: Sea buckthorn (Hippophae rhamnoides L.) as a traditional Chinese medicinal plant has various uses in Xinjiang. OBJECTIVE: A reversed-phase rapid-resolution liquid-chromatography method with diode array detector was developed for simultaneous determination of protocatechuic acid, rutin, quercetin, kaempferol, and isorhamnetin in the pulp and seed of sea buckthorn, a widely used traditional Chinese medicine for promoting metabolism and treating scurvy and other diseases...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28101580/crude-extract-and-solvent-fractions-of-calystegia-soldanella-induce-g1-and-s%C3%A2-phase-arrest-of-the-cell-cycle-in-hepg2-cells
#19
Jung Im Lee, In-Hye Kim, Taek-Jeong Nam
The representative halophyte Calystegia soldanella (L) Roem. et Schult is a perennial vine herb that grows in coastal dunes throughout South Korea as well as in other regions around the world. This plant has long been used as an edible and medicinal herb to cure rheumatic arthritis, sore throat, dropsy, and scurvy. Some studies have also shown that this plant species exhibits various biological activities. However, there are few studies on cytotoxicity induced by C. soldanella treatment in HepG2 human hepatocellular carcinoma cells...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28087031/dermoscopic-diagnosis-of-scurvy
#20
Carlos Gustavo Wambier, Mark Aaron Cappel, Betina Werner, Erika Rodrigues, Mariana Sandri Schumacher Welling, Mário Rodrigues Montemór Netto, Sarah Perillo de Farias Wambier
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
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