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https://www.readbyqxmd.com/read/29780794/pediatric-scurvy-when-contemporary-eating-habits-bring-back-the-past
#1
Alice Brambilla, Cristina Pizza, Donatella Lasagni, Lucia Lachina, Massimo Resti, Sandra Trapani
Vitamin C deficiency is anecdotal in developed countries, mainly associated with underling clinical morbidities as autism or neurological impairment. Chronic insufficient dietary supply is responsible for vascular fragility and impaired bone formation, resulting in gingival bleeding, petechial lesions, articular and bone pain or limb swelling. Children may present anorexia, irritability, failure to thrive, limping or refusal to walk. Accordingly, pediatric scurvy is frequently misdiagnosed with osteomyelitis, septic arthritis, bone and soft tissue tumor, leukemia, bleeding disorders, and rheumatologic conditions...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29706829/scurvy-in-2017-in-the-usa
#2
Krishna M Baradhi, Shobana Vallabhaneni, Supriya Koya
Vitamin C deficiency may be common in third-world countries due to malnutrition, but it is currently rare in the USA. Initially, nonspecific symptoms like exhaustion and depression may make this disease difficult to diagnose until classical dermatological manifestations appear. Diagnosis mainly relies on clinical presentation, dietary history to identify risk factors, and dramatic recession of symptoms and signs following vitamin C therapy. Human beings cannot synthesize vitamin C and hence need 90% of vitamin C intake from fruits and vegetables...
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29663975/gingival-enlargement-caused-by-vitamin-c-deficiency-scurvy-in-a-boy
#3
Adesh Kakade, Mugdha S Raut, Anitha Santosh, Saurabh Nagar, Shivani Bansal, Rajiv S Desai
Localized gingival enlargement associated with vitamin C deficiency (scurvy) is rarely encountered in the modern era. The purpose of this paper is to report a case of extensive inflammatory gingival enlargement in the mandibular anterior region associated with vitamin C deficiency in a 10 year-old boy. There was a significant improvement of the gingival enlargement seven days after starting oral vitamin C supplementation. Vitamin C deficiency should be included in the differential diagnosis of any gingival enlargement, especially in children...
January 15, 2018: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/29626027/lesson-of-the-month-1-massive-spontaneous-haematomas-in-an-elderly-man
#4
Francesco Fiorini, Louise Braddick, Hasnain Hashim, Robert M Ayto, Alana Jacobs, Yetunde Baoku, Shahir S Hamdulay
A 73-year-old man presented with bilateral leg pain and swelling, and no history of trauma or bleeding disorders. Clinical examination, biochemistry and magnetic resonance imaging of the thighs were suggestive of muscle haematomas. These progressed significantly during the admission, requiring blood transfusion. Normal vascular anatomy on computed tomography, renal and liver function, and absence of infection made a bleeding diathesis more likely. This may be caused by coagulation defects, platelet disorders and vascular fragility...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29602889/adult-scurvy-associated-with-psychiatric-disorders-and-breast-feeding
#5
Stefania Urueña-Palacio, Bruno L Ferreyro, Lucas G Fernández-Otero, Pablo D Calo
Scurvy is a nutritional disease caused by ascorbic acid deficiency and is potentially fatal. It was originally described in the 18th century by James Lind and associated with long sea voyages and insufficient citrus consumption. Its prevalence has declined markedly over the years but has still been described sporadically in certain countries. A 22-year-old woman with an anxiety disorder and anorexia nervosa, recent pregnancy and ongoing breast feeding, presented with a 10-day history of spontaneous haematomas in the lower limbs, gingivorrhagia and fatigue...
March 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29594144/an-unexpected-case-of-scurvy-in-a-peritoneal-dialysis-patient
#6
Raymonda El Khoury, Mitchell Warren, Saba Ali, James L Pirkle
This case describes an obese adult male peritoneal dialysis patient who presented with a pruritic follicular rash. Nutrient deficiency was not suspected initially in this case because there was no history of protein-calorie malnutrition, but the patient reported a diet devoid of fruits and vegetables and had not been taking his dialysis vitamin as prescribed. Skin biopsy showed follicular hyperkeratosis with fragmented hair shafts and corkscrew hairs consistent with scurvy. After supplementation with ascorbic acid 500 mg twice daily for 2 weeks, the rash resolved completely...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29542802/assessing-childhood-stress-in-early-mediaeval-croatia-by-using-multiple-lines-of-inquiry
#7
Mario Novak, Vlasta Vyroubal, Željko Krnčević, Maja Petrinec, Rachel Howcroft, Ron Pinhasi, Mario Slaus
Childhood stress, using both subadult and adult remains from early mediaeval (8th -11th c. CE) sites on the eastern Adriatic coast is analysed in this report. A total of 242 individuals (83 subadults, 69 adult females, and 90 adult males) were assessed for the presence of linear enamel hypoplasia, cribra orbitalia, sub-periosteal new bone formation, and scurvy. In addition, the dietary profile of nine subadults was assessed by the analysis of carbon and nitrogen stable isotopes from bulk collagen. Over three quarters of individuals with preserved permanent dentition (44/56 or 78...
May 1, 2018: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/29537414/james-lind-and-the-disclosure-of-failure
#8
S Justman
Though James Lind is renowned as a pioneer of the clinical trial, he records the 1747 trial aboard the Salisbury in passing, never followed up on it, never campaigned for clinical trials as a means of medical discovery, and eventually pronounced scurvy an insoluble enigma. The case can be made that in confessing his lack of an unfailing remedy for scurvy and his trouble making sense of the disease's behaviour, Lind did medicine a greater service than by conducting his now-famous trial. At the time, medical progress was hindered by the all-too-common practice of proclaiming success and concealing failure...
December 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29496210/response-to-gonz%C3%A3-lez-et-al-s-comment-upon-basilar-portion-porosity-a-pathological-lesion-possibly-associated-with-infantile-scurvy
#9
J Moore, H E C Koon
No abstract text is available yet for this article.
March 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29496209/comment-upon-basilar-portion-porosity-a-pathological-lesion-possibly-associated-with-infantile-scurvy
#10
A González Martín, F J Robles Rodríguez, O Cambra-Moo, J Rascón Pérez, M Campo Martín
No abstract text is available yet for this article.
March 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29477224/dietary-vitamin-c-in-human-health
#11
REVIEW
Matthew Granger, Peter Eck
Vitamin C is essential to prevent scurvy in humans and is implicated in the primary prevention of common and complex diseases such as coronary heart disease, stroke, and cancer. This chapter reviews the latest knowledge about dietary vitamin C in human health with an emphasis on studies of the molecular mechanisms of vitamin C maintenance as well as gene-nutrient interactions modifying these relationships. Epidemiological evidence indicates 5% prevalence for vitamin C deficiency and 13% prevalence for suboptimal status even in industrialized countries...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29425711/scurvy-as-a-mimicker-of-osteomyelitis-in-a-child-with-autism-spectrum-disorder
#12
Laura M Kinlin, Ana C Blanchard, Shawna Silver, Shaun K Morris
A case of scurvy in a 10-year-old boy with autism spectrum disorder is described. His clinical presentation was initially thought to be due to osteomyelitis, for which empirical antimicrobial therapy was initiated. Further invasive and ultimately unnecessary investigations were avoided when scurvy was considered in the context of a restricted diet and classic signs of vitamin C deficiency. Infectious diseases specialists should be aware of scurvy as an important mimicker of osteoarticular infections when involved in the care of patients at risk of nutritional deficiencies...
April 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29382002/latent-scurvy-with-tiredness-and-leg-pain-in-alcoholics-an-underestimated-disease-three-case-reports
#13
Christine Lux-Battistelli, Daniel Battistelli
RATIONALE: Scurvy is often diagnosed at the state of well-established signs as, for example, skin and visceral purpura, gums involvement, loss of healthy teeth, which derive mostly from disturbance of collagen metabolism. Little is known about the state of latent scurvy, which symptoms are nonspecific and may mimic more common conditions such as weakness, leg pain, and muscle aching. PATIENT CONCERNS: We report 3 cases of extreme lassitude and leg pain in alcoholics...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29369263/do-you-c-what-i-c-emergency-department-evaluation-and-diagnosis-of-pediatric-scurvy-in-an-autistic-child-with-a-restricted-diet
#14
James Burhop, Jennifer Gibson, Justin de Boer, Cyrus Heydarian
Scurvy in modern times may not be as rare as previously thought. The link between adequate intake of vitamin C and scurvy has been known since ancient times and is recorded in Ebers Papyrus. Recent reports indicate that, with restricted diets, vitamin C deficiency is being seen in infants exclusively fed plant-based formula and children with oral aversion, autism, restricted diets, and cerebral palsy. Additional at-risk groups include the older adults and patients having alcoholism. Often costly, emergency department visits and elaborate diagnostic studies lead to fruitless results when a simple diet history is often overlooked...
January 23, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29311535/the-medicinal-usage-and-restriction-of-ginseng-in-britain-and-america-1660-1900
#15
Heasim Sul
This article demonstrates the medicinal usage of ginseng in the West from 1660 to 1914. Asian[Korea] ginseng was first introduced into England in the early 17th century, and North American ginseng was found in the early 18th century. Starting from the late 17th century doctors prescribed ginseng to cure many different kinds of ailments and disease such as: fatigue general lethargy, fever, torpidity, trembling in the joints, nervous disorder, laughing and crying hysteria, scurvy, spermatic vessel infection, jaundice, leprosy, dry gripes and constipation, strangury, yellow fever, dysentery, infertility and addictions of alcohol, opium and tobacco, etc...
December 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/29274306/scurvy-a-not-so-ancient-disease
#16
Audrey W Jiang, Mahima Vijayaraghavan, Elliot G Mills, Anthony R Prisco, Joseph R Thurn
No abstract text is available yet for this article.
December 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29198404/paleopathological-rigor-and-differential-diagnosis-case-studies-involving-terminology-description-and-diagnostic-frameworks-for-scurvy-in-skeletal-remains
#17
Haagen D Klaus
Diverse pathological processes can produce overlapping or even indistinguishable patterns of abnormal bone formation or destruction, representing a fundamental challenge in the understanding of ancient diseases. This paper discusses increasing rigor in differential diagnosis through the paleopathological study of scurvy. First, paleopathology's use of descriptive terminology can strive to more thoroughly incorporate international standards of anatomical terminology. Second, improved observation and description of abnormal skeletal features can help distinguish between anemia or vitamin C deficiency...
December 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29198402/introduction-scientific-rigor-in-paleopathology
#18
Jane E Buikstra, Della C Cook, Katelyn L Bolhofner
This introductory chapter to the Special Issue on "Scientific Rigor in Paleopathology" serves to orient and introduce the chapters that follow through a detailed consideration of paleopathology as a 21st century intellectual field. In this vein, we first make the significant point that paleopathology is a profoundly interdisciplinary endeavor, encompassing aspects of the biomedical science, the humanities, and the social sciences. Thus, we suggest that no one practitioner can personally command the range of skills necessary for a 21st century paleopathologist...
December 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29099364/nutrition-for-oral-health-and-oral-manifestations-of-poor-nutrition-and-unhealthy-habits
#19
Matthew Pflipsen, Yevgeniy Zenchenko
The availability of proper nutrients is critical for the growth, development, maintenance, and repair of healthy dentition and oral tissues. Deficiencies particularly relevant to the dental practice are those in folate and other B complex vitamins; vitamins A, C, and D; calcium; fluoride; and protein. A lack of these nutrients affects nearly every structure in the oral cavity, causing or contributing to scurvy, cleft palate, enamel hypoplasia, poor mineralization, caries, and other pathoses. Damage to the dentition can also be observed in individuals with unhealthy habits; for example, a diet high in sugars will promote processes such as demineralization and caries...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/28894047/the-role-of-vitamin-c-in-epigenetic-regulation
#20
REVIEW
Jolanta Guz, Ryszard Oliński
Vitamin C (L-ascorbic acid) is a micronutrient best known for its anti-scurvy activity in humans. Vitamin C is involved in many biological processes involving enzymatic reactions that are catalyzed by members of dioxygenases which use Fe(II) and 2-oxoglutarate as a co-substrate.The article reviews recent data that suggest the involvement of ascorbate in dioxygenases catalyzed chromatin and DNA modifications which thereby contribute to epigenetic regulation. Concerning chromatin modification, the dioxygenases are involved in distinct demethylation reactions with varying specificity for the position of the lysine on the target histone...
August 24, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
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