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https://www.readbyqxmd.com/read/28447959/using-measurable-dosimetric-quantities-to-characterize-the-inter-structural-tradeoff-in-inverse-planning
#1
Hongcheng Liu, Peng Dong, Lei Xing
Traditional inverse planning relies on the use of weighting factors to balance the conflicting requirements of different structures. The manual trial-and-error determination of the weighting factors has long been recognized as a time-consuming part of treatment planning. The purpose of this work is to develop an inverse planning framework that parameterizes the dosimetric tradeoff among the structures with physically meaningful quantities to simplify the search for clinically sensible plans. In this formalism, instead of using the weighting factors, permissible variation range of the prescription dose or dose volume histogram (DVH) of the involved structures are used to characterize the "importance" of the structures...
April 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28444961/biodiversity-and-ecosystem-function-making-sense-of-numerous-species-interactions-in-multi-species-communities
#2
Caroline Brophy, Áine Dooley, Laura Kirwan, John A Finn, Jack McDonnell, Thomas Bell, Marc W Cadotte, John Connolly
Understanding the biodiversity and ecosystem function relationship can be challenging in species-rich ecosystems. Traditionally, species richness has been relied on heavily to explain changes in ecosystem function across diversity gradients. Diversity-Interactions models can test how ecosystem function is affected by species identity, species interactions and evenness, in addition to richness. However, in a species-rich system, there may be too many species interactions to allow estimation of each coefficient, and if all interaction coefficients are estimable, they may be devoid of any sensible biological meaning...
April 26, 2017: Ecology
https://www.readbyqxmd.com/read/28442720/lattice-dynamics-and-elasticity-for-%C3%AE%C2%B5-plutonium
#3
Per Söderlind
Lattice dynamics and elasticity for the high-temperature ε phase (body-centered cubic; bcc) of plutonium is predicted utilizing first-principles electronic structure coupled with a self-consistent phonon method that takes phonon-phonon interaction and strong anharmonicity into account. These predictions establish the first sensible lattice-dynamics and elasticity data on ε-Pu. The atomic forces required for the phonon scheme are highly accurate and derived from the total energies obtained from relativistic and parameter-free density-functional theory...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28440997/-neisseria-meningitidis-a-clinical-case-with-multi-organ-affection
#4
Alejandro Medina-Reyes, Beatriz Díaz-Polanco, Diego Sandoval-Chávez, Manuel Nodal-Hernández, Juan R Ayala-Franco
Neisseria meningitidis (Nm) is an agent feared for decades in the medical field due to its important morbidity and mortality. Ironically between 10 and 15% of the population will be asymptomatic carriers of this germ, which will also be ready to activate and manifest itself as a sickness at the right moment. We present the case of a nine-year-old girl who arrived at the Pediatric Emergency Service (to the Hospital General Region number 35, in Ciudad Juárez, Chihuahua) with the disease in multiple organs, where the Nm was isolated in the cerebrospinal fluid and in skin injuries, displaying three serotypes of Nm...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28439239/development-of-automated-patch-clamp-technique-to-investigate-cftr-chloride-channel-function
#5
Arnaud Billet, Lionel Froux, John W Hanrahan, Frederic Becq
The chloride (Cl(-)) channel cystic fibrosis transmembrane conductance regulator (CFTR) is defective in cystic fibrosis (CF), and mutation of its encoding gene leads to various defects such as retention of the misfolded protein in the endoplasmic reticulum, reduced stability at the plasma membrane, abnormal channel gating with low open probability, and thermal instability, which leads to inactivation of the channel at physiological temperature. Pharmacotherapy is one major therapeutic approach in the CF field and needs sensible and fast tools to identify promising compounds...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28438105/design-functionality-and-validity-of-the-swincare-a-web-based-application-used-to-administer-cancer-registry-records
#6
Giovanni Benedetto, Alessia Di Prima, Salvatore Sciacca, Giuseppe Grosso
We described the design of a web-based application (the Software Integrated Cancer Registry-SWInCaRe) used to administer data in a cancer registry and tested its validity and usability. A sample of 11,680 records was considered to compare the manual and automatic procedures. Sensibility and specificity, the Health IT Usability Evaluation Scale, and a cost-efficiency analysis were tested. Several data sources were used to build data packages through text-mining and record linkage algorithms. The automatic procedure showed small yet measurable improvements in both data linkage process and cancer cases estimation...
April 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28436922/the-feasibility-of-manual-parameter-tuning-for-deformable-breast-mr-image-registration-from-a-multi-objective-optimization-perspective
#7
Kleopatra Pirpinia, Peter Bosman, Claudette Loo, Gonneke Winter-Warnars, Natasja Janssen, Astrid Scholten, Jan-Jakob Sonke, Marcel van Herk, Tanja Alderliesten
Deformable image registration is typically formulated as an optimization problem involving a linearly weighted combination of terms that correspond to objectives of interest (e.g., similarity, deformation magnitude). The weights, along with multiple other parameters, need to be manually tuned for each application, a task currently mainly addressed via trial-and-error approaches. Such approaches can only be successful if there is a sensible interplay between parameters, objectives, and desired registration outcome...
April 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28436631/-video-head-impulse-test-for-evaluation-of-vestibular-function-in-patients-with-vestibular-neuritis-and-benign-paroxysmal-positional-vertigo
#8
Qiongfeng Guan, Lisan Zhang, Wenke Hong, Yi Yang, Zhaoying Chen, Dan Zhang, Xingyue Hu
Objective: To assess the clinical application of video head impulse test (vHIT) for vestibular function in vestibular neuritis (VN) and benign paroxysmal positional vertigo (BPPV) patients. Methods: Thirty-three patients with VN and 43 patients with BPPV were enrolled from Sir Run Run Shaw Hospital and Ningbo Second Hospital from March 15 to September 10, 2015; and 50 healthy controls were also enrolled in the study. vHIT was used to quantitatively test the vestibulo-ocular reflex (VOR) gains of a pair of horizontal semicircular canals...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28435072/development-of-a-pseudovirus-based-assay-for-measuring-neutralizing-antibodies-against-coxsackievirus-b5
#9
Pan Chen, Xing Wu, Yao Su, Xiaotian Hao, Qunying Mao, Zhenglun Liang
Coxsackievirus B5 (CV-B5), an important Coxsackie B virus from genus Enteroviruse within the family Picornaviridae, has also been isolated from Hand, Foot, and Mouth Disease (HFMD) patients, and often associated with neurological manifestations. In this study, we found out that Coxsackievirus B3 (CV-B3) replicon RNA could be encapsidated with CV-B5 capsid to assemble infectious CV-B5 pseudovirus. We then utilized this single round infection system of CV-B5 to develop a neutralizing antibody quantification assay...
April 20, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28434054/patterns-of-gambling-activities-and-gambling-problems-among-italian-high-school-students-results-from-a-latent-class-analysis
#10
Nicola De Luigi, Dino Gibertoni, Emanuela Randon, Antonello E Scorcu
This study aims to provide an estimate of the prevalence of gambling among Italian adolescents and a description of their patterns of gambling activities (PGAs) using a latent class analysis on 13 different types of games. A nationwide sample of 10,959 Italian high school students was recruited in 2013. We assessed problem gambling using the South Oaks Gambling Screen: Revisited for Adolescent (SOGS-RA) scale. Approximately half (50.6%) of students reported gambling at least once in the previous year; 5.0% of them were problem gamblers and 9...
April 22, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28434023/developing-a-statistically-powerful-measure-for-quartet-tree-inference-using-phylogenetic-identities-and-markov-invariants
#11
Jeremy G Sumner, Amelia Taylor, Barbara R Holland, Peter D Jarvis
Recently there has been renewed interest in phylogenetic inference methods based on phylogenetic invariants, alongside the related Markov invariants. Broadly speaking, both these approaches give rise to polynomial functions of sequence site patterns that, in expectation value, either vanish for particular evolutionary trees (in the case of phylogenetic invariants) or have well understood transformation properties (in the case of Markov invariants). While both approaches have been valued for their intrinsic mathematical interest, it is not clear how they relate to each other, and to what extent they can be used as practical tools for inference of phylogenetic trees...
April 22, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28432482/the-sensible-health-care-professional-a-care-ethical-perspective-on-the-role-of-caregivers-in-emotionally-turbulent-practices
#12
Vivianne Baur, Inge van Nistelrooij, Linus Vanlaere
This article discusses the challenging context that health care professionals are confronted with, and the impact of this context on their emotional experiences. Care ethics considers emotions as a valuable source of knowledge for good care. Thinking with care ethical theory and looking through a care ethical lens at a practical case example, the authors discern reflective questions that (1) shed light on a care ethical approach toward the role of emotions in care practices, and (2) may be used by practitioners and facilitators for care ethical reflection on similar cases, in the particular and concrete context where issues around emotional experiences arise...
April 21, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28430212/phase-retrieval-for-attacking-fractional-fourier-transform-encryption
#13
Dezhao Kong, Xueju Shen, Liangcai Cao, Guofan Jin
An advanced iterative phase retrieval algorithm is applied to perform a ciphertext-only attack on the fractional Fourier transform-based double random phase encryption system. With the given complex amplitude of ciphertext and definite support of the object image, the original object image can be recovered by estimating the energy of support area in the recovered image. The encryption system can be attacked by analyzing the sensibility of fractional Fourier transform order keys and evaluating the energy of the object image support area...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28426478/advocating-for-a-sensible-firearm-injury-prevention-plan
#14
Peter T Masiakos, Andrew L Warshaw
No abstract text is available yet for this article.
April 19, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28421696/assessing-causality-in-drug-policy-analyses-how-useful-are-the-bradford-hill-criteria-in-analysing-take-home-naloxone-programs
#15
Anna Olsen, David McDonald, Simon Lenton, Paul M Dietze
The Bradford Hill criteria for assessing causality are useful in assembling evidence, including within complex policy analyses. In this paper, we argue that the implementation of take-home naloxone (THN) programs in Australia and elsewhere reflects sensible, evidence-based public health policy, despite the absence of randomised controlled trials. However, we also acknowledge that the debate around expanding access to THN would benefit from a careful consideration of causal inference and health policy impact of THN program implementation...
April 18, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28421269/thermal-balance-of-nellore-cattle
#16
Cíntia Carol de Melo Costa, Alex Sandro Campos Maia, Sheila Tavares Nascimento, Carolina Cardoso Nagib Nascimento, Marcos Chiquitelli Neto, Vinícius de França Carvalho Fonsêca
This work aimed at characterizing the thermal balance of Nellore cattle from the system of indirect calorimetry using a facial mask. The study was conducted at the Animal Biometeorology Laboratory of the São Paulo State University, Jaboticabal, Brazil. Five male Nellore weighing 750 ± 62 kg, at similar ages and body conditions were distributed in four 5 × 5 Latin squares (5 days of records and five schedules) during 20 days. Physiological and environmental measurements were obtained from the indirect calorimetry system using a facial mask...
April 18, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28414695/imaging-criteria-to-predict-surgical-difficulties-during-stapes-surgery
#17
Claire Parra, Stéphanie Trunet, Benjamin Granger, Yann Nguyen, Georges Lamas, Daniele Bernardeschi, Rémi Hervochon, Frédéric Tankere
BACKGROUND AND PURPOSE: Stapes surgery for otosclerosis can be challenging if access to the oval window niche is restricted. The aim of this study was to determine the accuracy of the computed tomographic (CT) scan in the evaluation of anatomical distances, and to analyze its reliability in predicting surgical technical difficulties. MATERIAL AND METHODS: A total of 96 patients (101 ears) were enrolled in a prospective study between 2012 and May 2015. During surgery, we evaluated the distance D1 between the stapes and the facial nerve, distance D2 between the promontory and the facial nerve after ablation of the superstructure, and the intraoperative discomfort of the surgeon...
April 13, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28412981/differences-in-the-use-of-everyday-technology-among-persons-with-mci-sci-and-older-adults-without-known-cognitive-impairment
#18
Camilla Malinowsky, Anders Kottorp, Anders Wallin, Arto Nordlund, Eva Björklund, Ilse Melin, Anette Pernevik, Lena Rosenberg, Louise Nygård
BACKGROUND: To use valid subjective reports sensible to cognitive decline is vital to identify very early signs of dementia development. Use of everyday technology (ET) has been shown to be sensitive to differentiate adults with mild cognitive impairment (MCI) from controls, but the group with subjective cognitive impairment (SCI) has not yet been examined. This study aims to investigate and compare self-perceived ability in ET use and number of ETs reported as actually used in a sample of older adults with SCI, MCI, and older adults with no known cognitive impairment, i...
April 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28411475/extensibility-effect-of-poly-3-hexylthiophene-on-the-glucose-sensing-performance-of-mixed-poly-3-hexylthiophene-octadecylamine-glucose-oxidase-langmuir-blodgett-films
#19
Ke-Hsuan Wang, Wen-Ping Hsu, Liang-Huei Chen, Wei-Don Lin, Yuh-Lang Lee
Poly(3-hexylthiophene) (P3HT) is utilized as a material to enhance the glucose sensing performance of glucose oxidase (GOx) Langmuir-Blodgett (LB) films. To enhance the extensibility and homogeneity of the P3HT in the LB films, octadecylamine (ODA) is introduced. The characteristics of the mixed P3HT/ODA Langmuir monolayers are investigated first and then, utilized as template layers to adsorb GOx from the subphase, preparing P3HT/ODA/GOx Langmuir-Blodgett films for glucose sensing. The results show that P3HT molecules tend to aggregate at the air/liquid interface and, furthermore, the P3HT monolayer has a weak ability to adsorb GOx from the subphase...
April 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28408709/heritability-of-the-severity-of-the-metabolic-syndrome-in-whites-and-blacks-in-3-large-cohorts
#20
Solomon K Musani, Lisa J Martin, Jessica G Woo, Michael Olivier, Matthew J Gurka, Mark D DeBoer
BACKGROUND: Although dichotomous criteria for the metabolic syndrome (MetS) appear heritable, it is not known whether MetS severity as assessed by a continuous MetS score is heritable and whether this varies by race. METHODS AND RESULTS: We used SOLAR (Sequential Oligogenic Linkage Analysis Routines) to evaluate heritability of Adult Treatment Panel-III MetS and a sex- and race-specific MetS severity Z score among 3 large familial cohorts: the JHS (Jackson Heart Study, 1404 black participants), TOPS (Take Off Pounds Sensibly, 1947 white participants), and PLRS (Princeton Lipid Research Study, 229 black and 527 white participants)...
April 2017: Circulation. Cardiovascular Genetics
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