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https://www.readbyqxmd.com/read/29341054/-a-relational-ethical-model-for-the-assessment-of-decision-making-competence-in-psychiatry
#1
A Liégeois
Nowadays, partly due to legislation, decision-making competence is playing an ever-increasing role in psychiatry. So far, however, there are no clear criteria for evaluating the actual competence of the procedure.<br/> AIM: To develop a relational ethical model, including criteria and methodology, which can be used to assess and enhance decision-making competence mainly from a relational and ethical perspective.<br/> METHOD: Combination of a review of the literature and ethical reflection. First of all, a limited study was made of the literature relating to the concept of and criteria for decision-making competence...
2018: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29340775/global-versus-local-mechanisms-of-temperature-sensing-in-ion-channels
#2
REVIEW
Cristina Arrigoni, Daniel L Minor
Ion channels turn diverse types of inputs, ranging from neurotransmitters to physical forces, into electrical signals. Channel responses to ligands generally rely on binding to discrete sensor domains that are coupled to the portion of the channel responsible for ion permeation. By contrast, sensing physical cues such as voltage, pressure, and temperature arises from more varied mechanisms. Voltage is commonly sensed by a local, domain-based strategy, whereas the predominant paradigm for pressure sensing employs a global response in channel structure to membrane tension changes...
January 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29340506/-on-ethnographic-positions-in-the-anthropology-of-health-in-south-america
#3
María Epele
Ethnographies on health issues in populations that live in conditions of poverty, inequality and segregation have proliferated over the last decades in South America. The aim of this article is to problematize - preliminarily - certain patterns in the positions and relations of ethnographers with respect to study subjects and populations during their fieldwork and in the writing of study results. This paper examines the relationships between these ethnographic positions and the dominant theoretical perspectives in the region...
July 2017: Salud Colectiva
https://www.readbyqxmd.com/read/29337876/microenvironment-stimuli-hgf-and-hypoxia-differently-affected-mir-125b-and-ets-1-function-with-opposite-effects-on-the-invasiveness-of-bone-metastatic-cells-a-comparison-with-breast-carcinoma-cells
#4
Emanuela Matteucci, Paola Maroni, Francesco Nicassio, Francesco Ghini, Paola Bendinelli, Maria Alfonsina Desiderio
We examined the influence of microenvironment stimuli on molecular events relevant to the biological functions of 1833-bone metastatic clone and the parental MDA-MB231 cells. (i) In both the cell lines, hepatocyte growth factor (HGF) and the osteoblasts' biological products down regulated nuclear Ets-1-protein level in concomitance with endogenous miR-125b accumulation. In contrast, under hypoxia nuclear Ets-1 was unchanged, notwithstanding the miR-125b increase. (ii) Also, the 1833-cell invasiveness and the expression of Endothelin-1, the target gene of Ets-1/HIF-1, showed opposite patterns under HGF and hypoxia...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29336883/long-term-prognosis-of-pulpal-status-of-traumatized-teeth-exhibiting-contradictory-results-between-pulp-sensibility-test-and-ultrasound-doppler-flowmetry-a-retrospective-study
#5
So-Yeon Ahn, Dohyun Kim, Sung-Ho Park
INTRODUCTION: In this retrospective study, we investigated long-term (over 3 years) follow-up results of teeth that exhibited contradictory results between the pulp sensibility test (thermal or electric pulp test) and ultrasound Doppler flowmetry (UDF) until 1 year after trauma to inspect the prognosis of the pulp. METHODS: Data were collected from the records of trauma patients in our hospital between February 2012 and May 2015. The teeth that had continuously shown contrasting results on the pulp sensibility test and UDF until 1 year after trauma were chosen for the study...
January 12, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29335817/repurposing-existing-drugs-for-new-ampk-activators-as-a-strategy-to-extend-lifespan-a-computer-aided-drug-discovery-study
#6
Sepideh Mofidifar, Farzin Sohraby, Milad Bagheri, Hassan Aryapour
Dietary restriction is one of the several ways which could putatively extend organisms' lifespan, ranging from Saccharomyces cerevisiae to rodents, by activating the AMP-activated protein kinase (AMPK), an ATP/AMP sensor. Extensive researches have shown that aging reduces sensibility of AMPK and eventually causes energy imbalance in cells. Research in mammals' AMPK depicts that this signaling molecule could control autophagy, improve cellular stress resistance and suppress inflammatory responses. Hence, in this study we performed a drug repurposing of 1908 FDA-approved drugs in order to discover putative safe activators of AMPK and to find new applications for existing drugs...
January 15, 2018: Biogerontology
https://www.readbyqxmd.com/read/29333806/asq-3-validation-of-the-ages-and-stages-questionnaire-for-the-detection-of-neurodevelopmental-disorders-in-argentine-children
#7
Ana M Romero Otalvaro, Nora Grañana, Nadia Gaeto, María de Los Á Torres, María N Zamblera, María A Vasconez, Claudia Misenta, María E Rouvier, Jane Squires
INTRODUCTION: The systematic assessment of child development in the first years of life is an essential component of pediatric health checkups. The Ages and Stages Questionnaire, third edition (ASQ-3) is the most validated scale, and has been recommended by the UNICEF to verify if children have a normal neurological development. It is a monitoring instrument to assess the main developmental areas, including communication, gross motor, fine motor, personal-social, and problem solving skills, and to compare the local population to the international development standards...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29331491/investigating-the-relationship-between-cardiac-interoception-and-autonomic-cardiac-control-using-a-predictive-coding-framework
#8
Andrew P Owens, Karl J Friston, David A Low, Christopher J Mathias, Hugo D Critchley
Predictive coding models, such as the 'free-energy principle' (FEP), have recently been discussed in relation to how interoceptive (afferent visceral feedback) signals update predictions about the state of the body, thereby driving autonomic mediation of homeostasis. This study appealed to 'interoceptive inference', under the FEP, to seek new insights into autonomic (dys)function and brain-body integration by examining the relationship between cardiac interoception and autonomic cardiac control in healthy controls and patients with forms of orthostatic intolerance (OI); to (i) seek empirical support for interoceptive inference and (ii) delineate if this relationship was sensitive to increased interoceptive prediction error in OI patients during head-up tilt (HUT)/symptom provocation...
January 9, 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29330763/safe-and-sensible-preprocessing-and-baseline-correction-of-pupil-size-data
#9
Sebastiaan Mathôt, Jasper Fabius, Elle Van Heusden, Stefan Van der Stigchel
Measurement of pupil size (pupillometry) has recently gained renewed interest from psychologists, but there is little agreement on how pupil-size data is best analyzed. Here we focus on one aspect of pupillometric analyses: baseline correction, i.e., analyzing changes in pupil size relative to a baseline period. Baseline correction is useful in experiments that investigate the effect of some experimental manipulation on pupil size. In such experiments, baseline correction improves statistical power by taking into account random fluctuations in pupil size over time...
January 12, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29330658/patient-specific-model-based-segmentation-of-brain-tumors-in-3d-intraoperative-ultrasound-images
#10
Elisee Ilunga-Mbuyamba, Juan Gabriel Avina-Cervantes, Dirk Lindner, Felix Arlt, Jean Fulbert Ituna-Yudonago, Claire Chalopin
PURPOSE: Intraoperative ultrasound (iUS) imaging is commonly used to support brain tumor operation. The tumor segmentation in the iUS images is a difficult task and still under improvement because of the low signal-to-noise ratio. The success of automatic methods is also limited due to the high noise sensibility. Therefore, an alternative brain tumor segmentation method in 3D-iUS data using a tumor model obtained from magnetic resonance (MR) data for local MR-iUS registration is presented in this paper...
January 12, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29329929/detoxification-genes-polymorphisms-in-sids-exposed-to-tobacco-smoke
#11
Laura Filonzi, Cinzia Magnani, Anna Maria Lavezzi, Marina Vaghi, Luana Nosetti, Francesco Nonnis Marzano
The best hypothesis to explain Sudden Infant Death Syndrome (SIDS) pathogenesis is offered by the "triple risk model", which suggests that an interaction of different variables related to exogenous stressors and infant vulnerability may lead to the syndrome. Environmental factors are triggers that act during a particular sensible period, modulated by intrinsic genetic characteristics. Although literature data show that one of the major SIDS risk factors is smoking exposure, a specific involvement of molecular components has never been highlighted...
January 9, 2018: Gene
https://www.readbyqxmd.com/read/29321852/ignorance-can-be-evolutionarily-beneficial
#12
Jared M Field, Michael B Bonsall
Information is increasingly being viewed as a resource used by organisms to increase their fitness. Indeed, it has been formally shown that there is a sensible way to assign a reproductive value to information and it is non-negative. However, all of this work assumed that information collection is cost-free. Here, we account for such a cost and provide conditions for when the reproductive value of information will be negative. In these instances, counterintuitively, it is in the interest of the organism to remain ignorant...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29313539/characterisation-of-the-electronic-structure-of-galvinoxyl-free-radical-by-variable-energy-ups-xps-and-nexafs-spectroscopy
#13
Ivan Ljubić, Antti Kivimäki, Marcello Coreno, Saša Kazazić, Igor Novak
Insights into the electronic structure of galvinoxyl - a prototype persistent free radical species - are of interest to elucidate its attractive photophysical and magnetic properties and to pave way for a sensible design of novel applications. To this end, we study the photoionization and photoexcitation UPS, XPS and NEXAFS spectra of the gas-phase galvinoxyl in the valence and core (C 1s and O 1s) regions using synchrotron X-ray radiation. We observe significant variations of relative band intensities with photon energy for valence ionizations below 10 eV which are rationalized in terms of the properties of the corresponding valence molecular orbitals...
January 9, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29309604/detecting-gametocytes-how-sensitive-is-sensible
#14
Lisette Meerstein-Kessel, Teun Bousema, Will Stone
No abstract text is available yet for this article.
December 22, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29307022/fluorescein-videoangiography-during-extracranial-to-intracranial-bypass-surgery-preliminary-results
#15
Alessandro Narducci, Julia Onken, Marcus Czabanka, Nils Hecht, Peter Vajkoczy
BACKGROUND: Over the last years, intraoperative use of fluorescein is gaining ground in the field of neurosurgery, due to development of a microscope-integrated YELLOW 560 module, with reported experiences in brain malignancies, aneurysms, and arteriovenous malformation surgery. The aim of this study is to determine the feasibility and value of fluorescein videoangiography during bypass procedures. METHODS: The authors enrolled 11 patients who underwent extracranial-to-intracranial bypass for moyamoya disease, atherosclerotic steno-occlusive cerebrovascular disease, and flow replacement during a giant middle cerebral artery (MCA) aneurysm treatment...
January 6, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29306992/health-and-welfare-of-women-and-child-survival-a-key-to-nation-building
#16
Meharban Singh
Health of women has a profound effect on the health and welfare of communities, countries and the world at large. A large number of social, economic, educational, political and religious dimensions impact the lives of girls and women with repercussions on their health and status in society and welfare of their children. It is a sad reality that a large number of children, adolescents and women worldwide have limited or no access to essential health care services, nutrition and education. Gender inequity and discrimination against girls cannot be bridged unless there are equal opportunities for healthcare and education for boys and girls...
January 6, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29305762/the-dance-of-attention-toward-an-aesthetic-dimension-of-attention-deficit
#17
Kasper Levin
What role does the aesthetics of bodily movement play in the understanding of attention among children diagnosed with attention-deficit/hyperactivity disorder (ADHD)? This article animates a phenomenological approach to attention and embodiment with a special focus on the relation between aesthetic or expressive bodily movement and behavioral awareness in children diagnosed with ADHD. However, beyond this it is argued that the aesthetic aspect of movement calls for an expansion of the phenomenological perspective...
January 5, 2018: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/29304922/the-appropriate-use-of-opioids-in-the-treatment-of-refractory-restless-legs-syndrome
#18
Michael H Silber, Philip M Becker, Mark J Buchfuhrer, Christopher J Earley, William G Ondo, Arthur S Walters, John W Winkelman
Restless legs syndrome (RLS) is a distinct disorder, differing from chronic pain in many ways. Refractory RLS is characterized by unresponsiveness to dopamine agonists or alpha-2-delta ligands due to inadequate efficacy, augmentation, or adverse effects. This may result in severely impaired quality of life, profound insomnia, and suicidal depression. Opioid therapy is a mainstay in the management of these patients. This article summarizes the basic science and clinical evidence in support of their use, including the positive result of a large controlled multicenter study of 306 subjects, and outlines an approach to their use in clinical practice...
January 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29303371/the-management-of-deep-seated-low-grade-lipomatous-lesions
#19
Zeid Al-Ani, Malee Fernando, Victoria Wilkinson, Nikhil Kotnis
Deep-seated, low grade lipomatous lesions detected on imaging often cause uncertainty for diagnosis and treatment. Confidently distinguishing lipomas from well-differentiated liposarcomas (WDL) is often not possible on imaging. The approach to management of such lesions varies widely between institutions. Applying an evidenced-based approach set around published literature that clearly highlights how criteria such as lesion size, location, age and imaging features can be used to predict the risk of WDL and subsequent de-differentiation would seem sensible...
January 5, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29301631/primary-prevention-with-statins%C3%A2-in%C3%A2-the%C3%A2-elderly
#20
REVIEW
Martin Bødtker Mortensen, Erling Falk
The burden of atherosclerotic cardiovascular disease (ASCVD) in high-income countries is mostly borne by the elderly. With increasing life expectancy, clear guidance on sensible use of statin therapy to prevent a first and potentially devastating ASCVD event is critically important to ensure a healthy aging population. Since 2013, 5 major North American and European guidelines on statin use in primary prevention of ASCVD have been released by the American College of Cardiology/American Heart Association, the UK National Institute for Health and Care Excellence, the Canadian Cardiovascular Society, U...
January 2, 2018: Journal of the American College of Cardiology
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