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https://www.readbyqxmd.com/read/28814036/prosthetic-design-directives-low-cost-hands-within-reach
#1
G K Jones, A Rosendo, R Stopforth
Although three million people around the world suffer from the lack of one or both upper limbs 80% of this number is located within developing countries. While prosthetic prices soar with technology 3D printing and low cost electronics present a sensible solution for those that cannot afford expensive prosthetics. The electronic and control design of a low-cost prosthetic hand, the Touch Hand II, is discussed. This paper shows that sensorless techniques can be used to reduce design complexities, costs, and provide easier access to the electronics...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813974/a-cosmetic-prosthetic-digit-with-bioinspired-embedded-touch-feedback
#2
Diego Barone, Marco D'Alonzo, Marco Controzzi, Francesco Clemente, Christian Cipriani
Partial hand amputation is the most frequent amputation level worldwide, accounting for approximately 90% of all upper limb amputations. Passive cosmetic prostheses represent one of the possible choices for its treatment, probably the most affordable one. However, these devices restore very limited motor function and subtle sensory feedback. The latter is an important component for restoring the body schema. In this work we present a simple yet potentially effective and low cost cosmetic digital prosthesis that embeds touch feedback; we dubbed this DESC-finger...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28812671/sulfate-radicals-enable-a-non-enzymatic-krebs-cycle-precursor
#3
Markus A Keller, Domen Kampjut, Stuart A Harrison, Markus Ralser
The evolutionary origins of the Krebs cycle (tricarboxylic acid cycle) are not currently clear. Despite the existence of a simple non-enzymatic Krebs cycle catalyst being dismissed only a few years ago as 'an appeal to magic', citrate and other intermediates have since been discovered on a carbonaceous meteorite and do interconvert non-enzymatically. To identify a metabolism-like non-enzymatic Krebs cycle catalyst, we used combinatorial, quantitative high-throughput metabolomics to systematically screen iron and sulfate compounds in a reaction mixture that orients on the typical components of Archaean sediment...
March 13, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812307/the-development-of-perceptual-averaging-learning-what-to-do-not-just-how-to-do-it
#4
Pete R Jones, Tessa M Dekker
The mature visual system condenses complex scenes into simple summary statistics (e.g., average size, location, orientation, etc.). However, children, often perform poorly on perceptual averaging tasks. Children's difficulties are typically thought to represent the suboptimal implementation of an adult-like strategy. This paper examines another possibility: that children actually make decisions in a qualitatively different way to adults (optimal implementation of a non-ideal strategy). Ninety children (6-7, 8-9, 10-11 years) and 30 adults were asked to locate the middle of randomly generated dot-clouds...
August 15, 2017: Developmental Science
https://www.readbyqxmd.com/read/28811922/being-sensible-about-suicides
#5
John Watts
No abstract text is available yet for this article.
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28811032/recent-advancements-and-future-trends-in-environmental-analysis-sample-preparation-liquid-chromatography-and-mass-spectrometry
#6
REVIEW
Virginia Pérez-Fernández, Lucia Mainero Rocca, Pierpaolo Tomai, Salvatore Fanali, Alessandra Gentili
Among the thousands of chemicals having potential to enter the environment, the NORMAN network has identified at least 700 substances categorized into 20 classes in the European surface waters. Pesticides, pharmaceuticals, disinfection by-products, wood preservation and industrial chemicals are the prominent classes. Since the impact of these substances on aquatic life and human health might be dramatic, action is urgently required at multiple levels; one of them is just related to the development of more and more sensible and selective analytical methods...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28808349/dysregulation-of-photosynthetic-genes-in-oceanic-prochlorococcus-populations-exposed-to-organic-pollutants
#7
Maria-Carmen Fernández-Pinos, Maria Vila-Costa, Jesús M Arrieta, Laura Morales, Belén González-Gaya, Benjamin Piña, Jordi Dachs
The impact of organic pollutants on oceanic ecosystem functioning is largely unknown. Prochlorococcus, the most abundant known photosynthetic organism on Earth, has been suggested to be especially sensible to exposure to organic pollutants, but the sub-lethal effects of organic pollutants on its photosynthetic function at environmentally relevant concentrations and mixtures remain unexplored. Here we show the modulation of the expression of two photosynthetic genes, rbcL (RuBisCO large subunit) and psbA (PSII D1 protein), of oceanic populations of Prochlorococcus from the Atlantic, Indian and Pacific Oceans when exposed to mixtures of organic pollutants consisting of the non-polar fraction of a seawater extract...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807690/synergistic-effect-of-quercetin-and-ph-responsive-deae-chitosan-carriers-as-drug-delivery-system-for-breast-cancer-treatment
#8
Rafael de Oliveira Pedro, Francisco M Goycoolea, Susana Pereira, Carla C Schmitt, Miguel G Neumann
Amphiphilic chitosans, which may self-assemble in aqueous solution to form nanoaggregates with different conformations depending to the environmental pH, can be used as drug transport and delivery agents, when the target pH differs from the delivery medium pH. In this study, quercetin, a bioactive flavonoid, was encapsulated in a pH-responsive system based on amphiphilic chitosan. The hydrophilic reagent 2-chloro-N,N-diethylethylamine hydrochloride (DEAE), also known to inhibit the proliferation of cancer cells, was used as a grafting agent...
August 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28807371/treatment-outcome-following-direct-pulp-capping-using-bioceramic-materials-in-mature-permanent-teeth-with-carious-exposure-a%C3%A2-pilot%C3%A2-retrospective-study
#9
S Linu, M S Lekshmi, V S Varunkumar, V G Sam Joseph
INTRODUCTION: The aim of this study was to investigate the sequelae of direct pulp capping (DPC) using mineral trioxide aggregate (MTA) and Biodentine in mature permanent teeth with carious exposure. METHODS: Clinical records of 30 patients (15 each with MTA and Biodentine) treated with DPC technique from January 2015 to June 2015 were retrieved. Success rates (based on symptoms, sensibility tests, and radiographic analysis) and adverse events were analyzed. RESULTS: The patients were reviewed at 1, 3, 6, 12, and 18 months after treatment...
August 11, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28806738/partial-igf-1-deficiency-is-sufficient-to-reduce-heart-contractibility-angiotensin-ii-sensibility-and-alter-gene-expression-of-structural-and-functional-cardiac-proteins
#10
José Luis González-Guerra, Inma Castilla-Cortazar, Gabriel A Aguirre, Úrsula Muñoz, Irene Martín-Estal, Elena Ávila-Gallego, Miriam Granado, Juan E Puche, Ángel Luis García-Villalón
Circulating levels of IGF-1 may decrease under several circumstances like ageing, metabolic syndrome, and advanced cirrhosis. This reduction is associated with insulin resistance, dyslipidemia, progression to type 2 diabetes, and increased risk for cardiovascular diseases. However, underlying mechanisms between IGF-1 deficiency and cardiovascular disease remain elusive. The specific aim of the present work was to study whether the partial IGF-1 deficiency influences heart and/or coronary circulation, comparing vasoactive factors before and after of ischemia-reperfusion (I/R)...
2017: PloS One
https://www.readbyqxmd.com/read/28806102/effects-of-alcohol-consumption-on-blood-pressure-in-hypertensive-women
#11
Naomi Deirdre Lakshmi Fisher, Endel John Orav, Grace Chang
BACKGROUND: Problem drinking carries significant health burdens, including an increased risk of hypertension. The effect of chronic alcohol intake on blood pressure (BP) in women is understudied and poorly understood. OBJECTIVES: We sought to examine the relationships between drinking habits and BP in hypertensive women. METHODS: We analyzed drinking habits in 113 women followed in the Brigham and Women's Hospital Hypertension Clinic for at least one year...
August 14, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28804980/using-bayes-factors-to-evaluate-evidence-for-no-effect-examples-from-the-sips-project
#12
Zoltan Dienes, Simon Coulton, Nick Heather
AIMS: To illustrate how Bayes Factors are important for determining the effectiveness of interventions. METHOD: We consider a case where inappropriate conclusions were publicly drawn based on significance testing, namely the SIPS Project (Screening and Intervention Programme for Sensible drinking), a pragmatic, cluster-randomized controlled trial in each of two healthcare settings and in the criminal justice system. We show how Bayes Factors can disambiguate the non-significant findings from the SIPS Project and thus determine whether the findings represent evidence of absence or absence of evidence...
August 13, 2017: Addiction
https://www.readbyqxmd.com/read/28801739/-the-new-treatment-procedures-of-the-dguv-from-the-perspective-of-an-injury-type-procedure-vav-clinic
#13
REVIEW
M Oberst
The new treatment procedures of the German Statutory Accident Insurance (DGUV) have ramifications for the injury type procedure clinics (VAV) from medical, economic and structural aspects. Whereas the latter can be assessed as positive, the medical and economical aspects are perceived as being negative. Problems arise from the partially unclear formulation of the injury type catalogue, which results in unpleasant negotiations with the occupational insurance associations with respect to financial remuneration for services rendered...
August 11, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28801221/the-aminoacyl-trna-synthetases-had-only-a-marginal-role-in-the-origin-of-the-organization-of-the-genetic-code-evidence-in-favor-of-the-coevolution-theory
#14
Massimo Di Giulio
The coevolution theory of the origin of the genetic code suggests that the organization of the genetic code coevolved with the biosynthetic relationships between amino acids. The mechanism that allowed this coevolution was based on tRNA-like molecules on which - this theory - would postulate the biosynthetic transformations between amino acids to have occurred. This mechanism makes a prediction on how the role conducted by the aminoacyl-tRNA synthetases (ARSs), in the origin of the genetic code, should have been...
August 9, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28798430/contemporary-operative-caries-management-consensus-recommendations-on-minimally-invasive-caries-removal
#15
A Banerjee, J E Frencken, F Schwendicke, N P T Innes
The International Caries Consensus Collaboration (ICCC) presented recommendations on terminology, on carious tissue removal and on managing cavitated carious lesions. It identified 'dental caries' as the name of the disease that dentists should manage, and the importance of controlling the activity of existing cavitated lesions to preserve hard tissues, maintain pulp sensibility and retain functional teeth in the long term. The ICCC recommended the level of hardness (soft, leathery, firm, and hard dentine) as the criterion for determining the clinical consequences of the disease and defined new strategies for carious tissue removal: 1) Selective removal of carious tissue - including selective removal to soft dentine and selective removal to firm dentine; 2) stepwise removal - including stage 1, selective removal to soft dentine, and stage 2, selective removal to firm dentine 6 to 12 months later; and 3) non-selective removal to hard dentine - formerly known as complete caries removal (a traditional approach no longer recommended)...
August 11, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28794447/the-role-of-local-heating-in-the-2015-indian-heat-wave
#16
Debjani Ghatak, Benjamin Zaitchik, Christopher Hain, Martha Anderson
India faced a major heat wave during the summer of 2015. Temperature anomalies peaked in the dry period before the onset of the summer monsoon, suggesting that local land-atmosphere feedbacks involving desiccated soils and vegetation might have played a role in driving the heat extreme. Upon examination of in situ data, reanalysis, satellite observations, and land surface models, we find that the heat wave included two distinct peaks: one in late May, and a second in early June. During the first peak we find that clear skies led to a positive net radiation anomaly at the surface, but there is no significant sensible heat flux anomaly within the core of the heat wave affected region...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28792427/the-psychosexual-impact-of-postmastectomy-breast-reconstruction
#17
Alexandra M Hart, Ximena Pinell-White, Albert Losken
BACKGROUND: The surgical management of breast cancer with mastectomy and breast reconstruction (BR) has been shown to increase the quality of life of cancer survivors. Yet the impact of surgery on sexuality, femininity, and condition of intimate relationships as a measure for sexual health has not been fully evaluated. METHODS: Ninety-six women who underwent mastectomy and immediate BR participated in the series. Surveys assessed patients' level of sexual health in the areas of femininity, sexual confidence during intimate relationships, and the role of breast sensibility in sexual satisfaction as compared with how they felt preoperatively...
November 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28789798/development-of-a-validated-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-method-for-determination-of-acid-diterpenes-in-copaifera-oleoresins
#18
Jonas Joaquim Mangabeira da Silva, Eduardo José Crevelin, Luiza Junqueira Carneiro, Hervé Rogez, Rodrigo Cassio Sola Veneziani, Sérgio Ricardo Ambrósio, Luiz Alberto Beraldo Moraes, Jairo Kenupp Bastos
Species of Copaifera genus (Fabaceae - Caesalpinoiodidaeae) produces an important commercial oleoresin that displays many medicinal properties. Copaifera oleoresins (COR) are composed mainly of a mixture of diterpenes and sequiterpenes, and the main reported acid diterpenes for this genus are kaurenoic, copalic, hardwickiic and polyaltic acids. An ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for identification and quantification of nine acid diterpenes...
July 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28777994/nitrogen-removal-and-n2o-emission-in-subsurface-wastewater-infiltration-systems-with-without-intermittent-aeration-under-different-organic-loading-rates
#19
Yingying Jiang, Yafei Sun, Jing Pan, Shiyue Qi, Qiuying Chen, Deli Tong
Nitrogen removal, N2O emission and nitrogen removal functional gene abundances in intermittent aerated (IA) and non-aerated (NA) subsurface wastewater infiltration systems (SWISs) under different organic loading rates (OLRs) were investigated. Aeration successfully created aerobic condition at 50cm depth and did not change anoxic or anaerobic condition at 80 and 110cm depths under OLR of 5.3, 10.9 and 16.5g BOD/(m(2)d). Meanwhile, aeration enhanced COD, NH4(+)-N, TN removal and the enrichment of nitrogen removal functional genes (amoA, nxrA, napA, narG, nirS, nirK, qnorB and nosZ) compared to NA SWIS...
July 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28777969/method-validation-and-nanoparticle-characterization-assays-for-an-innovative-amphothericin-b-formulation-to-reach-increased-stability-and-safety-in-infectious-diseases
#20
Maraine Catarina Tadini, Ana Maria de Freitas Pinheiro, Daniel Blascke Carrão, Ana Luiza Scarano Aguillera Forte, Sofia Nikolaou, Anderson R M de Oliveira, Andresa Aparecida Berretta, Franciane Marquele-Oliveira
Drug Delivery Systems (DDS) of known drugs are prominent candidates towards new and more-effective treatments of various infectious diseases as they may increase drug bioavailability, control drug delivery and target the site of action. In this sense, the encapsulation of Amphotericin B (AmB) in Nanostructured Lipid Carriers (NLCs) designed with pH-sensible phospholipids to target infectious tissues was proposed and suitable analytical methods were validated, as well as, proper nanoparticle characterization were conducted...
July 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
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