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https://www.readbyqxmd.com/read/27926988/prognosis-of-teeth-in-the-line-of-jaw-fractures
#1
Kamaldeep K Aulakh, Tejinder Kaur, Sumeet Sandhu
BACKGROUND/AIM: The decision as to whether teeth in the line of jaw fractures should be extracted or retained remains a controversial issue. The aim of this study was to assess the prognosis of teeth directly in the line of, and adjacent to jaw fracture sites. MATERIALS AND METHODS: The study consisted of 50 patients with facial fractures in the dentate region, the diagnosis of which was made on the basis of clinical and radiographic examinations. A total of 124 teeth were present in 69 fracture sites (50 patients), of which 89 teeth were evaluated both, clinically (tooth mobility, pocket depth, pulp sensibility) and with periapical radiographs (degree of fracture displacement, marginal bone loss, root resorption)...
December 7, 2016: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/27925103/health-needs-and-nursing-care
#2
Cristina Buischi Petersen, Regina Aparecida Garcia de Lima, Magali Roseira Boemer, Semiramis Melani Melo Rocha
Objective: to present the concept of needs according to different approaches to discuss the possibility of health care that incorporates a broader view of human vulnerabilities in health services. Methods: the arguments are founded on nursing theorists who worked on the construction of frameworks relevant to care, based on needs and on philosophers who show the possibility of identifying the vulnerabilities of human beings, defending art as a therapeutic instrument that can promote health care...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27919021/a-lost-track-in-ichd-3-beta-a-comprehensive-review-on-osmophobia
#3
Giorgio Zanchin, Matteo Fuccaro, Pierantonio Battistella, Mario Ermani, Federico Mainardi, Ferdinando Maggioni
BACKGROUND: Osmophobia (Os) has been reported to be much more prevalent in migraine (M) than in other primary headaches, and its high specificity in the differential diagnosis between M and tension-type headache (TTH) has been reported. Os was included in the ICHD II Appendix as a diagnostic criterion of M. It disappeared in ICHD-3 beta. To understand this choice, we reviewed the literature after 2004. METHODS: This was a systematic review. We searched in PubMed, MEDLINE and Cochrane library for "osmophobia", "odour/odorphobia AND headache", "odour/odor hypersensitivity AND headache" and "olfactory hypersensitivity AND headache"...
November 14, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27919011/cardiovascular-autonomic-and-hemodynamic-responses-to-vagus-nerve-stimulation-in-drug-resistant-epilepsy
#4
Iñigo Garamendi, Marian Acera, Marta Agundez, Lara Galbarriatu, Ainhoa Marinas, Iñigo Pomposo, Elena Valle, Jose-Alberto Palma, Juan C Gomez-Esteban
PURPOSE: Vagus nerve stimulation (VNS) is used as an adjunctive therapy for treating patients with drug-resistant epilepsy. The impact of VNS on cardiovascular autonomic function remains to be fully understood. We determined changes in cardiovascular sympathetic and parasympathetic, and hemodynamic function in association with VNS in patients with drug-resistant focal epilepsy. METHOD: Longitudinal (n=15) evaluation of beat-to-beat blood pressure (BP) and heart rate variability (HRV), baroreflex sensibility, and hemodynamic function performed before VNS implantation, 6-months after implantation, and a mean of 12-months after implantation; and cross-sectional study (n=14) of BP and HR variability and baroreflex sensitivity during VNS on and VNS off...
December 2, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27918902/development-of-an-intensive-care-unit-resource-assessment-survey-for-the-care-of-critically-ill-patients-in-resource-limited-settings
#5
Aleksandra Leligdowicz, Satish Bhagwanjee, Janet V Diaz, Wei Xiong, John C Marshall, Robert A Fowler, Neill Kj Adhikari
PURPOSE: Capacity to provide critical care in resource-limited settings is poorly understood because of lack of data about resources available to manage critically ill patients. Our objective was to develop a survey to address this issue. METHODS: We developed and piloted a cross-sectional self-administered survey in 9 resource-limited countries. The survey consisted of 8 domains; specific items within domains were modified from previously developed survey tools...
November 5, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27916120/development-and-statistical-assessment-of-a-paper-based-immunoassay-for-detection-of-tumor-markers
#6
Thiago Mazzu-Nascimento, Giorgio Gianini Morbioli, Luis Aparecido Milan, Fabiana Cristina Donofrio, Carlos Alberto Mestriner, Emanuel Carrilho
Paper-based assays are an attractive low-cost option for clinical chemistry testing, due to characteristics such as short time of analysis, low consumption of samples and reagents, and high portability of assays. However, little attention has been given to the evaluation of the performance of these simple tests, which should include the use of a statistical approach to define the choice of best cut-off value for the test. The choice of the cut-off value impacts on the sensitivity and specificity of the bioassay...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27912843/the-reduced-concentration-of-citrate-in-cancer-cells-an-indicator-of-cancer-aggressiveness-and-a-possible-therapeutic-target
#7
Icard Philippe, Lincet Hubert
Proliferating cells reduce their oxidative metabolism and rely more on glycolysis, even in the presence of O2 (Warburg effect). This shift in metabolism reduces citrate biosynthesis and diminishes intracellular acidity, both of which promote glycolysis sustaining tumor growth. Because citrate is the donor of acetyl-CoA, its reduced production favors a deacetylation state of proteins favoring resistance to apoptosis and epigenetic changes, both processes contributing to tumor aggressiveness. Citrate levels could be monitored as an indicator of cancer aggressiveness (as already shown in human prostate cancer) and/or could serve as a biomarker for response to therapy...
November 2016: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/27908660/targeting-of-multiple-senescence-promoting-genes-and-signaling-pathways-by-triptonide-induces-complete-senescence-of-acute-myeloid-leukemia-cells
#8
Yanyan Pan, Mei Meng, Nana Zheng, Zhifei Cao, Ping Yang, Xiaodong Xi, Quansheng Zhou
Leukemia cells aberrantly overexpress senescence-suppression telomerase reverse transcriptase (TERT) and down-regulate key senescence-promoting genes to escape complete senescence, resulting in immortalization and malignant progression. Accordingly, induction of complete senescence is a sensible strategy for anti-leukemia therapy. However, effective senescence-based anti-leukemia drugs with low toxicity are currently lacking. In this study, we found that triptonide (chemical name diterpene triepoxide), a small molecule derived from the herb Tripterygium wilfordii Hook, strongly induced complete senescence in cultured acute myeloid leukemia (AML) cell lines, and potently inhibited growth and colony formation of U937 and HL-60 AML cell line with IC50 values of 7...
November 28, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27895595/moving-from-histopathology-to-molecular-tools-in-the-diagnosis-of-molluscs-diseases-of-concern-under-eu-legislation
#9
REVIEW
Raquel Aranguren, Antonio Figueras
One of the main factors limiting molluscs production is the presence of pathogens and diseases. Disease agent transfer via transfers of live molluscs has been a major cause of disease outbreaks and epizootics. Because of that, the European Union has adopted several decisions and directives, the last in 2006 (2006/88/EC) to control movements of marine organisms over the European countries. Once the disease is established in a determined area its eradication is a complicated task because life cycle of pathogens are not completely known and only a good and early diagnosis of the disease could be the most appropriate way to deal with it...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27891706/rectal-intussusception-can-high-resolution-three-dimensional-ano-rectal-manometry-compete-with-conventional-defecography
#10
A Benezech, M Cappiello, K Baumstarck, J-C Grimaud, M Bouvier, V Vitton
BACKGROUND: Three-dimensional high-resolution anorectal manometry (3DHRAM), used for exploring anorectal disorders, was recently developed, providing interesting topographic data for the diagnosis of pelvic floor disorders such as excessive perineal descent. The aim of our study was to define a diagnostic strategy based on selected 3DHRAM parameters to identify rectal intussusceptions (RI), considering conventional defecography (CD) as the gold standard. METHODS: All patients referred to our center in the previous 6 months for 3DHRAM to explore fecal incontinence or constipation, and who previously achieved CD, were eligible...
November 27, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27891629/capping-carious-exposures-in-adults-a-randomized-controlled-trial-investigating-mineral-trioxide-aggregate-versus-calcium-hydroxide
#11
R Kundzina, L Stangvaltaite, H M Eriksen, E Kerosuo
AIM: The aim of this multicentre, parallel-group randomized clinical trial was to compare the effectiveness of mineral trioxide aggregate (MTA) and a conventional calcium hydroxide liner (CH) as direct pulp capping materials in adult molars with carious pulpal exposure. METHODOLOGY: Seventy adults aged 18-55 years were randomly allocated to two parallel arms: MTA (White ProRoot, Dentsply, Tulsa Dental, Tulsa, OK, USA; n = 33) and CH (Dycal(®) , Dentsply DeTrey GmbH, Konstanz, Germany; n = 37)...
November 7, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27891569/chair-side-generated-posterior-monolithic-lithium-disilicate-crowns-clinical-survival-after-6%C3%A2-years
#12
Angelika Rauch, Sven Reich, Oliver Schierz
OBJECTIVES: The objective of this prospective clinical study was to evaluate the clinical performance of chair-side generated monolithic lithium disilicate crowns after 72 months. MATERIALS AND METHODS: Forty-one posterior full contour crowns made of lithium disilicate ceramic were inserted in 34 patients with a chair-side CAD/CAM technique. One crown per patient was randomly selected for evaluation at baseline, 6, 12, 24, 36, 48, 60 and 72 months according to the modified US Public Health Service criteria...
November 28, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27884354/computing-methods-for-composite-clinical%C3%A2-endpoints-in-unprotected-left-main-coronary-artery-revascularization-a-post-hoc-analysis-of-the-delta-registry
#13
Davide Capodanno, Giuseppe Gargiulo, Sergio Buccheri, Alaide Chieffo, Emanuele Meliga, Azeem Latib, Seung-Jung Park, Yoshinobu Onuma, Piera Capranzano, Marco Valgimigli, Inga Narbute, Raj R Makkar, Igor F Palacios, Young-Hak Kim, Pawel E Buszman, Tarun Chakravarty, Imad Sheiban, Roxana Mehran, Christoph Naber, Ronan Margey, Arvind Agnihotri, Sebastiano Marra, Martin B Leon, Jeffrey W Moses, Jean Fajadet, Thierry Lefèvre, Marie-Claude Morice, Andrejs Erglis, Ottavio Alfieri, Patrick W Serruys, Antonio Colombo, Corrado Tamburino
OBJECTIVES: The study sought to investigate the impact of different computing methods for composite endpoints other than time-to-event (TTE) statistics in a large, multicenter registry of unprotected left main coronary artery (ULMCA) disease. BACKGROUND: TTE statistics for composite outcome measures used in ULMCA studies consider only the first event, and all the contributory outcomes are handled as if of equal importance. METHODS: The TTE, Andersen-Gill, win ratio (WR), competing risk, and weighted composite endpoint (WCE) computing methods were applied to ULMCA patients revascularized by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) at 14 international centers...
November 28, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27882587/-pushing-the-button-while-pushing-the-argument-motor-priming-of-abstract-action-language
#14
Franziska Schaller, Sabine Weiss, Horst M Müller
In a behavioral study we analyzed the influence of visual action primes on abstract action sentence processing. We thereby aimed at investigating mental motor involvement during processes of meaning constitution of action verbs in abstract contexts. In the first experiment, participants executed either congruous or incongruous movements parallel to a video prime. In the second experiment, we added a no-movement condition. After the execution of the movement, participants rendered a sensibility judgment on action sentence targets...
November 24, 2016: Cognitive Science
https://www.readbyqxmd.com/read/27881806/how-do-gloves-affect-cutaneous-sensibility-in-medical-practice-two-new-applied-tests
#15
Peter Mylon, Matt J Carré, Nicolas Martin, Roger Lewis
In order to quantify the effect of medical gloves on tactile performance, two new Simulated Medical Examination Tactile Tests (SMETT) have been developed to replicate the tactile and haptic ability required in medical examinations: the 'Bumps' test and the 'Princess and the Pea' (P&P) test. A pilot study was carried out using 30-40 subjects for each test in order to investigate the suitability of the tests for medical glove evaluation. Tests were performed with latex and nitrile examination gloves and without gloves...
November 23, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/27881189/pharmaceutical-patenting-and-the-transformation-of-american-medical-ethics
#16
Joseph M Gabriel
The attitudes of physicians and drug manufacturers in the US toward patenting pharmaceuticals changed dramatically from the mid-nineteenth century to the mid-twentieth. Formerly, physicians and reputable manufacturers argued that pharmaceutical patents prioritized profit over the advancement of medical science. Reputable manufactures refused to patent their goods and most physicians shunned patented products. However, moving into the early twentieth century, physicians and drug manufacturers grew increasingly comfortable with the idea of pharmaceutical patents...
November 24, 2016: British Journal for the History of Science
https://www.readbyqxmd.com/read/27881172/eigenspace-based-beamformer-using-oblique-signal-subspace-projection-for-ultrasound-plane-wave-imaging
#17
Saeid Aliabadi, Yuanyuan Wang, Jinhua Yu, Jinxin Zhao, Wei Guo, Shun Zhang
BACKGROUND: The Eigenspace-based beamformers, by orthogonal projection of signal subspace, can remove a large part of the noise, and provide better imaging contrast upon the minimum variance beamformer. However, wrong estimate of signal and noise component may bring dark-spot artifacts and distort the signal intensity. The signal component and noise and interference components are considered uncorrelated in conventional eigenspace-based beamforming methods. In ultrasound imaging, however, signal and noise are highly correlated...
November 24, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27881153/verification-of-trex1-as-a-promising-indicator-of-judging-the-prognosis-of-osteosarcoma
#18
Jinyi Feng, Ruilong Lan, Guanxiong Cai, Jinluan Lin, Xinwen Wang, Jianhua Lin, Deping Han
BACKGROUND: The study aimed to explore the correlation between the expression of TREX1 and the metastasis and the survival time of patients with osteosarcoma as well as biological characteristics of osteosarcoma cells for the prognosis judgment of osteosarcoma. METHOD: The correlation between the expression of TREX1 protein and the occurrence of pulmonary metastasis in 45 cases of osteosarcoma was analyzed. The CD133(+) and CD133(-) cell subsets of osteosarcoma stem cells were sorted by the flow cytometry...
November 24, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27877848/towards-sensible-toxicity-testing-for-nanomaterials-proposal-for-the-specification-of-test-design
#19
Annegret Potthoff, Mirco Weil, Tobias Meißner, Dana Kühnel
During the last decade, nanomaterials (NM) were extensively tested for potential harmful effects towards humans and environmental organisms. However, a sound hazard assessment was so far hampered by uncertainties and a low comparability of test results. The reason for the low comparability is a high variation in the (1) type of NM tested with regard to raw material, size and shape and (2) procedures before and during the toxicity testing. This calls for tailored, nanomaterial-specific protocols. Here, a structured approach is proposed, intended to lead to test protocols not only tailored to specific types of nanomaterials, but also to respective test system for toxicity testing...
December 2015: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27876709/low-energy-microscopic-models-for-iron-based-superconductors-a-review
#20
Rafael M Fernandes, Andrey V Chubukov
The development of sensible microscopic models is essential to elucidate the normal-state and superconducting properties of the iron-based superconductors. Because these materials are mostly metallic, a good starting point is an effective low-energy model that captures the electronic states near the Fermi level and their interactions. However, in contrast to cuprates, iron-based high-T c compounds are multi-orbital systems with Hubbard and Hund interactions, resulting in a rather involved 10-orbital lattice model...
November 23, 2016: Reports on Progress in Physics
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