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https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#1
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29777764/deformation-behavior-of-crystallized-mannitol-during-compression-using-a-rotary-tablet-press-simulator
#2
Nicolas Tarlier, Ian Soulairol, Noelia Sanchez-Ballester, Gilles Baylac, Adrien Aubert, Philippe Lefevre, Bernard Bataille, Tahmer Sharkawi
Mannitol is commonly used as a pharmaceutical excipient for tablets; the most widely used oral dosage form for drug delivery. For tableting, mannitol is provided in two different forms: native crystals and textured particles. In order to optimize its formulation, a good understanding of the mechanical behavior mechanism of mannitol is necessary. Thus, the aim of this study is to evaluate the deformation mechanism of native mannitol crystals presenting different particle sizes. Pharmaco-technical and compression studies were performed using mannitol with different mean diameters (160 µm, 50 µm and 25 µm)...
May 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29770665/-study-on-rapid-recognition-technique-of-schistosome-susceptibility-water-body-i-animal-skin-making-and-effect-assessment
#3
Peng Guo-Hua, Wei Wang-Yuan, Qian Ke, Hu Zhu-Hua, Li Shi-Zhu, Guo Jia-Gang, Yu Qing
OBJECTIVE: To develop a bionic animal skin and evaluate its detective effect of Schistosoma japonicum cercariae so as to provide a new technique for the monitoring of the schistosome susceptibility water body. METHODS: A bionic animal skin was made with pigskin and the experiments were carried out for evaluating its detective effects of S. japonicum cercariae in laboratory and simulate fields, and at the same time, the sentinel mouse method was used as the control...
April 17, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29770283/cardiac-amyloidosis-diagnosis-with-magnetic-resonance-imaging-a-case-report
#4
Meidi El Issa, Malik El Issa, Besma Sidia
Amyloidosis is a rare disease, which can affect various organs, such as the kidneys, heart, liver, respiratory and gastrointestinal tracts, and the nervous system. It still has a bad prognosis nowadays, despite chemotherapy and the new biotherapies. Its physiopathology corresponds to an irreversible, extracellular accumulation of fibrillous proteins in the tissues. Notwithstanding the fact that a clear diagnosis can be made with histology (of solid injured organs or a subcutaneous biopsy), magnetic resonance imaging (MRI) can show various advantages, especially to prove cardiac involvement, with great specificity and sensibility as well...
March 15, 2018: Curēus
https://www.readbyqxmd.com/read/29768583/self-reported-weight-and-height-are-valid-measures-to-determine-weight-status-results-from-the-brazilian-national-health-survey-pns-2013
#5
Naiara Ferraz Moreira, Verônica Gronau Luz, Caroline Camila Moreira, Rosângela Alves Pereira, Rosely Sichieri, Márcia Gonçalves Ferreira, Ana Paula Muraro, Paulo Rogério Melo Rodrigues
Self-reported measures have been used to obtain weight and height information in some epidemiological surveys. The validation of such information is necessary to guarantee data quality. This study assessed the validity of self-reported weight and height to determine weight status. Data were obtained in the Brazilian National Health Survey, a Brazilian household-based nationwide survey carried out in 2013. In this survey, 40,366 individuals (aged ≥ 18 years) provided self-reported and measured information about weight and height...
May 10, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29765048/sensible-heat-has-significantly-affected-the-global-hydrological-cycle-over-the-historical-period
#6
G Myhre, B H Samset, Ø Hodnebrog, T Andrews, O Boucher, G Faluvegi, D Fläschner, P M Forster, M Kasoar, V Kharin, A Kirkevåg, J-F Lamarque, D Olivié, T B Richardson, D Shawki, D Shindell, K P Shine, C W Stjern, T Takemura, A Voulgarakis
Globally, latent heating associated with a change in precipitation is balanced by changes to atmospheric radiative cooling and sensible heat fluxes. Both components can be altered by climate forcing mechanisms and through climate feedbacks, but the impacts of climate forcing and feedbacks on sensible heat fluxes have received much less attention. Here we show, using a range of climate modelling results, that changes in sensible heat are the dominant contributor to the present global-mean precipitation change since preindustrial time, because the radiative impact of forcings and feedbacks approximately compensate...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29760481/protein-intake-in-hospitalized-older-people-with-and-without-increased-risk-of-malnutrition
#7
Emmelyne Vasse, Janne Beelen, Nicole M de Roos, Nancy Janssen, Lisette Cpgm de Groot
A protein intake of ≥1.2 grams per kg body weight (g/kg) is recommended for ill older adults. In a cross-sectional study, we investigated if this recommendation was met by 62 hospitalized adults of 65 years and older in a Dutch hospital. We compared protein intake between two subgroups based on the risk of malnutrition and the prescribed diet: a low risk group (n = 31) receiving a standard hospital diet and a medium/high risk group (n = 31) receiving a protein-enriched diet. A 24h-recall was performed to calculate protein intake per patient...
May 15, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29755710/laboratory-biomarkers-to-facilitate-differential-diagnosis-between-measles-and-kawasaki-disease-in-a-pediatric-emergency-room-a-retrospective-study
#8
Danilo Buonsenso, Giulia Macchiarulo, Maria Chiara Supino, Francesco La Penna, Simona Scateni, Alessandra Marchesi, Antonino Reale, Elena Boccuzzi
This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD criteria (p > 0.5) but significant differences in white blood cell count, neutrophils, CRP and LDH levels (p < 0.001). LDH value ≥ 800 mg/dl had sensibility of 89% and specificity of 90% for Measles while CRP ≥ 3 mg/dl had sensibility 89% and specificity of 85% for KD...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29753987/accounting-for-no-net-loss-a-critical-assessment-of-biodiversity-offsetting-metrics-and-methods
#9
Maria Jose Carreras Gamarra, James Philip Lassoie, Jeffrey Milder
Biodiversity offset strategies are based on the explicit calculation of both losses and gains necessary to establish ecological equivalence between impact and offset areas. Given the importance of quantifying biodiversity values, various accounting methods and metrics are continuously being developed and tested for this purpose. Considering the wide array of alternatives, selecting an appropriate one for a specific project can be not only challenging, but also crucial; accounting methods can strongly influence the biodiversity outcomes of an offsetting strategy, and if not well-suited to the context and values being offset, a no net loss outcome might not be delivered...
May 10, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29752700/neuro-radiological-features-can-predict-hypopituitarism-in-primary-autoimmune-hypophysitis
#10
Tommaso Tartaglione, Sabrina Chiloiro, Maria Elena Laino, Antonella Giampietro, Simona Gaudino, Angelo Zoli, Antonio Bianchi, Alfredo Pontecorvi, Cesare Colosimo, Laura De Marinis
Primary autoimmune hypophysitis (PAH) is considered an underdiagnosed disease, due to the difficulty in reaching a definitive diagnosis. PAH clinical diagnosis remains an exclusion diagnosis. We aimed to correlate PAH neuro-radiological signs to endocrine features and evaluate their prognostic role. 24 PAH cases were enrolled and classified according to neuro-radiological signs: in 12 adeno-hypophysitis (AHs), 8 infundibulo-neuro-hypophysitis (INHs) and 4 pan-hypophysitis (PHs). Secondary hypogonadism developed more frequently in INHs as compared to AHs (54...
May 11, 2018: Pituitary
https://www.readbyqxmd.com/read/29748830/-give-me-five-ultra-hypofractionated-radiotherapy-for-localized-prostate-cancer-non-invasive-ablative-approach
#11
Giulia Marvaso, Giulia Riva, Delia Ciardo, Sara Gandini, Cristiana Fodor, Dario Zerini, Sarah Pia Colangione, Giorgia Timon, Stefania Comi, Raffaella Cambria, Federica Cattani, Ottavio De Cobelli, Roberto Orecchia, Barbara A Jereczek-Fossa
Ultra-hypofractionated radiotherapy (RT) is given over a shorter time with larger doses with respect to conventional fractionation in patients with localized prostate cancer (PCa). The use of hypofractionation is supported both from the radiobiological point of view (the low α/β-ratio in PCa and dose escalation) and from the rising number of clinical evidences. The aim of this study is to review our data regarding oncological outcomes, namely biochemical progression-free survival (b-PFS) and clinical progression-free survival (c-PFS), acute and long-term toxicities in patients treated with a ultra-hypofractionated RT...
May 10, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29748110/interoceptive-processing-deficit-a-behavioral-marker-for-subtyping-parkinson-s-disease
#12
Gabriella Santangelo, Carmine Vitale, Chiara Baiano, Alfonsina D'Iorio, Katia Longo, Paolo Barone, Marianna Amboni, Massimiliano Conson
BACKGROUND: Non-motor symptoms in Parkinson's disease (PD), such as cognitive, emotional, autonomic and somatosensory alterations, are not ubiquitous but vary between the tremor dominant (TD) and postural instability/gait difficulty (PIGD) subtypes of the syndrome. Non-motor phenomena (e.g., anxiety, depression and apathy) have been related to representation of autonomic and somatosensory sensations (interoception), and recent findings suggest interoceptive deficits in PD. OBJECTIVES: To test whether interoceptive processing is differently affected in TD and PIGD phenotypes, by assessing both interoceptive accuracy and sensibility in PD patients with TD and PIGD subtypes, and in healthy controls...
May 5, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29746903/randomized-clinical-trial-of-famciclovir-or-acyclovir-for-the-treatment-of-herpes-zoster-in-adults
#13
Henrique Pott Junior, Monalisa F Bocchi de Oliveira, Sheley Gambero, Roberto Bleuel Amazonas
BACKGROUND: This study investigated the safety and effectiveness of famciclovir compared to acyclovir in patients with herpes zoster to determine if both regimens are equally suited to treat uncomplicated herpes zoster patients for 7 days. METHODS: Patients were randomly assigned to receive either Famciclovir 500mg (one tablet) t.i.d. or Acyclovir 800mg (two capsules) five times daily for 7 days. The primary endpoint was defined as the time to full crusting of herpes zoster lesions...
May 7, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29745159/-responses-of-photosynthetic-characteristics-in-leaves-of-physocarpus-amurensis-and-p-opulifolius-to-drought-stress
#14
Nan Xu, Xiang Xin-Yue Meng, Xi Ming Zhao, Chang Ai, Jia Qi Sun, Si Yu Zhang, Cong Yang Zhang, Hui Hui Zhang
This experiment was conducted to study the responses of photosynthetic gas exchange parameters and the chlorophyll fluorescence parameters in leaves to soil drought. Furthermore, the drought resistance abilities of the endangered native Physocarpus amurensis and the introduced P. opulifolius as well as their differences were studied. The results showed that the leaves of P. opulifolius wilted significantly, while the leaf water content and water use efficiency of the native P. amurensis were higher on the 7th day after soil drought...
June 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29744638/effects-of-trigeminal-training-on-trigeminal-sensitivity-and-self-rated-nasal-patency
#15
Anna Oleszkiewicz, Timo Schultheiss, Valentin A Schriever, Jana Linke, Mandy Cuevas, Antje Hähner, Thomas Hummel
PURPOSE: Patients with the feeling of a congested nose not always suffer from an anatomical obstruction but might just have a low trigeminal sensibility, which prevents them from perceiving the nasal airstream. We examined whether intermittent trigeminal stimulation increases sensitivity of the nasal trigeminal nerve and whether this effect is accompanied by subjective improvement of nasal breathing. METHOD: Thirty-five patients (Mage  = 58.4 years; SD = 14...
May 9, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29743486/the-relation-between-natural-variations-in-ocean-heat-uptake-and-global-mean-surface-temperature-anomalies-in-cmip5
#16
Sybren Drijfhout
It is still unclear whether a hiatus period arises due to a vertical redistribution of ocean heat content (OHC) without changing ocean heat uptake (OHU), or whether the increasing radiative forcing is associated with an increase in OHU when global mean surface temperature (GMST) rise stalls. By isolating natural variability from forced trends and performing a more precise lead-lag analysis, we show that in climate models TOA radiation and OHU do anti-correlate with natural variations in GMST, when GMST leads or when they coincide, but the correlation changes sign when OHU leads...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742462/the-link-between-interoceptive-processing-and-anxiety-in-children-diagnosed-with-autism-spectrum-disorder-extending-adult-findings-into-a-developmental-sample
#17
E R Palser, A Fotopoulou, E Pellicano, J M Kilner
Anxiety is a major associated feature of autism spectrum disorders. The incidence of anxiety symptoms in this population has been associated with altered interoceptive processing. Here, we investigated whether recent findings of impaired interoceptive accuracy (quantified using heartbeat detection tasks) and exaggerated interoceptive sensibility (subjective sensitivity to internal sensations on self-report questionnaires) in autistic adults, can be extended into a school-age sample of children and adolescents (n = 75)...
May 6, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29741143/zinc-finger-nuclease-combines-with-cisplatin-and-trichostatin-a-enhances-the-antitumor-potency-in-cervical-cancer-cells
#18
Ci Ren, Hui Wang, Wencheng Ding, Chun Gao, Xiaomin Li, Hui Shen, Liming Wang, Da Zhu, Peng Wu, Ding Ma
Cervical cancer is the third-most common malignant tumor among women worldwide, which seriously endangers the life and health of Chinese women. The primary etiological factor of cervical cancer is persistent infection with high-risk human papillomavirus (HR-HPV), particularly HPV16 and HPV18. HR-HPV express oncoproteins E6 and E7, both of which play key roles in the progression of cervical carcinogenesis. Zinc Finger Nucleases (ZFNs) targeting HPVE7 induce specific shear of the E7 gene, weakening the malignant biological effects, hence showing great potential for clinical transformation...
May 9, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29740769/degradation-of-carbendazim-in-water-via-photo-fenton-in-raceway-pond-reactor-assessment-of-acute-toxicity-and-transformation-products
#19
Elizângela Pinheiro da Costa, Sue Ellen C Bottrel, Maria Clara V M Starling, Mônica M D Leão, Camila Costa Amorim
This study aimed at investigating the degradation of fungicide carbendazim (CBZ) via photo-Fenton reactions in artificially and solar irradiated photoreactors at laboratory scale and in a semi-pilot scale Raceway Pond Reactor (RPR), respectively. Acute toxicity was monitored by assessing the sensibility of bioluminescent bacteria (Aliivibrio fischeri) to samples taken during reactions. In addition, by-products formed during solar photo-Fenton were identified by liquid chromatography coupled to mass spectrometry (UFLC-MS)...
May 8, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29739528/innovative-educational-initiatives-to-train-psychodynamic-psychiatrists-in-underserved-areas-of-the-world
#20
REVIEW
César A Alfonso, Marco Christian Michael, Sylvia Detri Elvira, Hazli Zakaria, Rasmon Kalayasiri, Aida Syarinaz A Adlan, Mahdieh Moinalghorabaei, Petrin Redayani Lukman, Mohammad San'ati, Katerina Duchonova, Timothy B Sullivan
Psychodynamic psychiatry remains a challenging subject to teach in underserved areas, where enthusiasm to learn is substantial. Besides logistical and psychiatric workforce shortcomings, sensible cultural adaptations to make psychodynamic psychiatry relevant outside of high-income countries require creative effort. Innovative pedagogical methods that include carefully crafted mentoring and incorporate videoconferencing in combination with site visits can be implemented through international collaborations. Emphasis on mentoring is essential to adequately train future psychodynamic psychotherapy supervisors...
June 2018: Psychiatric Clinics of North America
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