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https://www.readbyqxmd.com/read/28733812/melatonin-increases-reactive-aggression-in-humans
#1
Jinting Liu, Ru Zhong, Wei Xiong, Haibo Liu, Christoph Eisenegger, Xiaolin Zhou
OBJECTIVE: Melatonin, a hormone released preferentially by the pineal gland during the night, affects circadian rhythms and aging processes. As animal studies have shown that melatonin increases resident-intruder aggression, this study aimed to investigate the impact of melatonin treatment on human aggression. METHODS: In a double-blind, randomized, placebo-controlled between-participant design, 63 healthy male volunteers completed the Taylor Aggression Paradigm (TAP) after oral administration of melatonin or placebo...
July 21, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28730284/a-novel-interplay-between-hotair-and-dna-methylation-in-osteosarcoma-cells-indicates-a-new-therapeutic-strategy
#2
Xingang Li, Hongming Lu, Guilian Fan, Miao He, Yu Sun, Kai Xu, Fengjun Shi
PURPOSE: Osteosarcoma (OS) is one of the most prevalent primary malignant bone tumors in adolescent. HOTAIR is highly expressed and associated with the epigenetic modifications, especially DNA methylation, in cancer. However, the regulation mechanism between HOTAIR and DNA methylation and the biological effects of them in the pathogenesis of osteosarcoma remains elusive. METHOD: Through RNA-sequencing and computational analysis, followed by a variety of experimental validations, we report a novel interplay between HOTAIR, miR-126, and DNA methylation in OS...
July 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28729521/influence-of-block-copolymer-feature-size-on-reactive-ion-etching-pattern-transfer-into-silicon
#3
Masoud Dialameh, Federico Ferrarese Lupi, Dario Imbraguglio, Fabio Zanenga, Alessio Lamperti, Davide Martella, Gabriele Seguini, Michele Perego, Andrea Mario Rossi, Natascia De Leo, Luca Boarino
A successful realization of sub 20 nm features on silicon is becoming the focus of many technological studies, strongly influencing the future performance of modern integrated circuits. Although reactive ion etching (RIE), at both micrometric and nanometric scale has already been the target of many studies, a better understanding of the different mechanisms involved at sub 20 nm size etching is still required. In this work, we investigated the influence of the feature size on etch rate of silicon, performed by Cryogenic RIE process through cylinder-forming polystyrene-block-polymethilmetacrhlate (PS-b-PMMA) DiBlock Copolymers (DBCs) masks with diameter ranging between 19 and 13 nm...
July 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28723493/proteinuria-in-patients-undergoing-renal-cancer-surgery-impact-on-overall-survival-and-stability-of-renal-function
#4
Zhiling Zhang, Juping Zhao, Joseph Zabell, Erick Remer, Jianbo Li, Jack Campbell, Wen Dong, Diego Aguilar Palacios, Tulsi Patel, Sevag Demirjian, Steven C Campbell
BACKGROUND: Proteinuria is included in the Kidney Disease: Improving Global Outcomes (KDIGO) risk stratification for chronic kidney disease (CKD) in the general population. However, the importance of proteinuria in patients with renal cancer has not been adequately studied. OBJECTIVE: To evaluate the prognostic impact of preoperative proteinuria on overall survival (OS) and renal function stability (RFS) for patients managed with renal cancer surgery. DESIGN, SETTING, AND PARTICIPANTS: From 1999 to 2008, 977 patients who underwent renal cancer surgery had preoperative data recorded for the glomerular filtration rate (GFR) estimated using the CKD Epidemiology Collaboration equation (G1 ≥90, G2 60-89, G3a 45-59, G3b 30-44, G4 15-29, and G5 <15ml/min/1...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720383/preliminary-behavioral-assessment-of-cagemates-living-with-conspecifics-submitted-to-chronic-restraint-stress-in-mice
#5
Paulo E Carneiro de Oliveira, Caroline R Zaniboni, Isabela M Carmona, Aura R Fonseca, Azair Canto-de-Souza
The capacity of rodents to recognize and respond to emotional signs from a conspecific is a valuable adaptive behavior, which provides essential skills for species survival. However, repeated exposure to aversive situations may elicit maladaptive behavioral responses in subjects that experience noxious episodes and their colony members. Previous findings by our group demonstrated that living with a subject in neuropathic pain induces anxiogenic-like behaviors and hypernociception in mice. Whereas chronic pain may be considered a stressful stimulus, we extended our findings on stress-induced emotional transfer...
July 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28718657/bitter-taste-of-brassica-vegetables-the-role-of-genetic-factors-receptors-isothiocyanates-glucosinolates-and-flavor-context
#6
Martyna N Wieczorek, Michał Walczak, Marzena Skrzypczak-Zielińska, Henryk H Jeleń
It is well known that consumption of Brassica vegetables has beneficial effect on human's health. The greatest interest is focused on glucosinolates and their hydrolysis products isothiocyanates, due to their potential as cancer preventing compounds. Brassica vegetables are also rich in flavor compounds belonging to many chemical groups. The main sensory sensation related to these vegetable is their characteristic sharp and bitter taste, and unique aroma. Because of these features this group of vegetables is often rejected by consumers...
July 18, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28716047/protocol-adherence-for-continuously-titrated-interventions-in-randomized-trials-an-overview-of-the-current-methodology-and-case-study
#7
F Lauzier, N K Adhikari, A Seely, K K Y Koo, E P Belley-Côté, K E A Burns, D J Cook, F D'Aragon, B Rochwerg, M E Kho, S J W Oczkowksi, E H Duan, M O Meade, A G Day, F Lamontagne
BACKGROUND: The standard definition for protocol adherence is the proportion of all scheduled doses that are delivered. In clinical research, this definition has several limitations when evaluating protocol adherence in trials that study interventions requiring continuous titration. DISCUSSION: Building upon a specific case study, we analyzed a recent trial of a continuously titrated intervention to assess the impact of different definitions of protocol deviations on the interpretation of protocol adherence...
July 17, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28713507/multi-arrhythmias-detection-with-an-xml-rule-based-system-from-12-lead-electrocardiogram
#8
Abdeldjalil Khelassi, Sarra-Nassira Yelles-Chaouche, Faiza Benais
BACKGROUND: The computer-aided detection of cardiac arrhythmias stills a crucial application in medical technologies. The rule based systems RBS ensure a high level of transparency and interpretability of the obtained results. AIM: To facilitate the diagnosis of the cardiologists and to reduce the uncertainty made in this diagnosis. METHODS: In this research article, we have realized a classification and automatic recognition of cardiac arrhythmias, by using XML rules that represent the cardiologist knowledge...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28712634/management-of-dens-invaginatus-type-ii-associated-with-immature-apex-and-large-periradicular-lesion-using-platelet-rich-fibrin-and-biodentine
#9
Shruti Goel, Ruchika Roongta Nawal, Sangeeta Talwar
Dens invaginatus (DI) poses peculiar challenges in endodontic treatment of teeth because of distortion of pulpal space. A case of Oehlers type II DI with open apex and large periapical lesion is reported. The case was managed using cone-beam computed tomography (CBCT), operating microscope, platelet-rich fibrin (PRF), and Biodentine. A 15-year-old male patient presented with palatal swelling. Pulp sensibility testing of right maxillary lateral incisor was negative. Intraoral periapical digital radiograph revealed an Oehlers type II DI with open apex and periapical radiolucency...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28709600/challenges-in-conducting-clinical-trials-in-nephrology-conclusions-from-a-kidney-disease-improving-global-outcomes-kdigo-controversies-conference
#10
Colin Baigent, William G Herrington, Josef Coresh, Martin J Landray, Adeera Levin, Vlado Perkovic, Marc A Pfeffer, Peter Rossing, Michael Walsh, Christoph Wanner, David C Wheeler, Wolfgang C Winkelmayer, John J V McMurray
Despite the high costs of treatment of people with kidney disease and associated comorbid conditions, the amount of reliable information available to guide the care of such patients is very limited. Some treatments have been assessed in randomized trials, but most such trials have been too small to detect treatment effects of a magnitude that would be realistic to achieve with a single intervention. Therefore, KDIGO convened an international, multidisciplinary controversies conference titled "Challenges in the Conduct of Clinical Trials in Nephrology" to identify the key barriers to conducting trials in patients with kidney disease...
August 2017: Kidney International
https://www.readbyqxmd.com/read/28708626/effects-of-hydraulic-loading-rate-and-aeration-mode-on-nitrogen-removal-and-nitrogen-functional-gene-abundances-in-subsurface-wastewater-infiltration-systems
#11
Yafei Sun, Jing Pan, Shiyue Qi, Hexin Fei
Matrix dissolved oxygen, nitrogen removal and nitrogen functional gene abundances in two artificial aeration modes, continuous aeration (CA) and intermittent aeration (IA), in subsurface wastewater infiltration systems (SWISs) under different hydraulic loading rates (HLRs) were investigated. Aeration not only successfully created aerobic conditions at 50 cm depth, but also did not change anoxic or anaerobic conditions at 80 and 110 cm depths. Meanwhile, aeration significantly enhanced chemical oxygen demand, NH4(+)-N, and total nitrogen (TN) removal and the enrichment of nitrogen removal functional genes (amoA, nxrA, napA, narG, nirK and qnorB) compared to the non-aerated SWIS, especially for high HLRs...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28708441/safe-monsplasty-technique
#12
Audrey Patoué, Antoine De Runz, Raphael Carloni, Sylvie Aillet, Eric Watier, Nicolas Bertheuil
INTRODUCTION: To improve their health and quality of life, obese patients undergo consultation after weight loss. In these patients, the sub-umbilical abdominal and pubic regions are often characterized by redundant skin, creating aesthetic and functional discomfort. Monsplasty is an important step in abdominoplasty or bodylift procedures. We report on an original technique used to correct deformity in the pubic region following weight loss. METHODS: All interventions were performed by the same surgeon between April and December 2015...
July 14, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28705928/miniaturized-radiochemical-purity-testing-for-99m-tc-hmpao-99m-tc-hmdp-and-99m-tc-tetrofosmin
#13
Ana de la Fuente, Roberta Zanca, Angela Gabriella Cataldi, Roberto Boni, Martina Sollini, Elena Lazzeri, Giuliano Mariani, Paola Anna Erba
Quick methods are functional in clinical practice in order to ensure the fastest availability of radiopharmaceuticals. For this purpose, we investigated the radiochemical purity of the widely used (99m)Tc-HMDP (hydroxymethylene diphosphonate), (99m)Tc-HMPAO (hexamethylpropyleneamine oxime) and (99m)Tc-Tetrofosmin by reducing time as compared to the manufacturer's method. Methods: We applied a miniaturized chromatographic method with a reduced strip development from 18 cm to 9 cm for all three radiopharmaceuticals...
July 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28705637/-do-children-with-attention-deficit-and-hyperactivity-disorder-adhd-have-a-diferent-gait-pattern-relationship-between-idiopathic-toe-walking-and-adhd
#14
Víctor Soto Insuga, Beatriz Moreno Vinués, Rebeca Losada Del Pozo, María Rodrigo Moreno, Marta Martínez González, Raquel Cutillas Ruiz, Carmen Mateos Carmen
INTRODUCTION: Idiopathic toe-walking (ITW) is described as a gait pattern with no contact between the heels and the ground in children older than 3years. The diagnosis is clinical, making it necessary to rule out other neurological and orthopaedic conditions. A relationship between ITW and vestibular dysfunction and/or proprioceptive sensibility has been proposed. Children with neurodevelopmental disorders (autism, language and cognitive disorders) often have ITW. OBJECTIVES: To determine the frequency of ITW in children with attention deficit disorder and hyperactivity (ADHD)...
July 10, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28705456/feeling-touch-on-the-own-hand-restores-the-capacity-to-visually-discriminate-it-from-someone-else-hand-pathological-embodiment-receding-in-brain-damage-patients
#15
Carlotta Fossataro, Valentina Bruno, Patrizia Gindri, Lorenzo Pia, Anna Berti, Francesca Garbarini
The sense of body ownership, i.e., the belief that a specific body part belongs to us, can be selectively impaired in brain-damaged patients. Recently, a pathological form of embodiment has been described in patients who, when the examiner's hand is located in a body-congruent position, systematically claim that it is their own hand (E+ patients). This paradoxical behavior suggests that, in these patients, the altered sense of body ownership also affects their capacity of visually discriminating the body-identity details of the own and the alien hand, even when both hands are clearly visible on the table...
June 23, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28704892/is-electrocochleography-still-helpful-in-early-diagnosis-of-meniere-disease
#16
Fulvio Mammarella, Melissa Zelli, Theodoros Varakliotis, Alberto Eibenstein, Claudio Maria Pianura, Gianluca Bellocchi
BACKGROUND AND OBJECTIVES: Despite the extensive research for the Meniere's disease (MD), it's pathophysiology still remains uncertain and questionable among scientists. Clinical symptoms and audiometric tests form the basis for the diagnosis. Nevertheless the differential diagnosis can be extremely challenging, due to subjective and not specific results. Incorrect diagnosis is most likely and for this reason there is a great demand for objective and reliable tests. SUBJECTS AND METHODS: The presence of endolymphatic hydrops is necessary condition but non enough for the diagnosis...
July 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28704209/robotic-hand-assisted-training-for-spinal-cord-injury-driven-by-myoelectric-pattern-recognition-a-case-report
#17
Zhiyuan Lu, Kai-Yu Tong, Henry Shin, Argyrios Stampas, Ping Zhou
A 51-year-old man with an incomplete C6 spinal cord injury sustained 26 yrs ago attended twenty 2-hr visits over 10 wks for robot-assisted hand training driven by myoelectric pattern recognition. In each visit, his right hand was assisted to perform motions by an exoskeleton robot, while the robot was triggered by his own motion intentions. The hand robot was designed for this study, which can perform six kinds of motions, including hand closing/opening; thumb, index finger, and middle finger closing/opening; and middle, ring, and little fingers closing/opening...
July 12, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28702055/evaluation-of-sensibility-threshold-for-interocclusal-thickness-of-patients-wearing-complete-dentures
#18
Kujtim Sh Shala, Linda J Dula, Teuta Pustina-Krasniqi, Teuta Bicaj, Enis F Ahmedi, Zana Lila-Krasniqi, Arlinda Tmava-Dragusha
OBJECTIVE: The aim of this study was to evaluate sensibility threshold for interocclusal thickness in experienced and nonexperienced denture wearers after the insertion of new complete dentures. MATERIALS AND METHODS: A total of 88 patients with complete dentures have participated in this study. The research was divided into two experimental groups, compared with the previous experience prosthetic dental treatment. The sensibility threshold for interocclusal thickness was measured with metal foil with 8 μm thickness and width of 8 mm, placed between the upper and lower incisor region...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28701167/a-combined-experimental-and-numerical-study-on-upper-airway-dosimetry-of-inhaled-nanoparticles-from-an-electrical-discharge-machine-shop
#19
Lin Tian, Yidan Shang, Rui Chen, Ru Bai, Chunying Chen, Kiao Inthavong, Jiyuan Tu
BACKGROUNDS: Exposure to nanoparticles in the workplace is a health concern to occupational workers with increased risk of developing respiratory, cardiovascular, and neurological disorders. Based on animal inhalation study and human lung tumor risk extrapolation, current authoritative recommendations on exposure limits are either on total mass or number concentrations. Effects of particle size distribution and the implication to regional airway dosages are not elaborated. METHODS: Real time production of particle concentration and size distribution in the range from 5...
July 12, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28694432/seasonal-variation-modulates-coral-sensibility-to-heat-stress-and-explains-annual-changes-in-coral-productivity
#20
Tim Scheufen, Wiebke E Krämer, Roberto Iglesias-Prieto, Susana Enríquez
The potential effects of seasonal acclimatization on coral sensitivity to heat-stress, has received limited attention despite differing bleaching thresholds for summer and winter. In this study, we examined the response of two contrasting phenotypes, termed winter and summer, of four Caribbean reef corals to similar light and heat-stress levels. The four species investigated were categorized into two groups: species with the ability to harbour large number of symbionts, Orbicella annularis and O. faveolata, and species with reduced symbiont density (Montastraea cavernosa and Pseudodiploria strigosa)...
July 10, 2017: Scientific Reports
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