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https://www.readbyqxmd.com/read/28433500/psychometric-characteristics-of-the-matrics-consensus-cognitive-battery-in-a-large-pooled-cohort-of-stable-schizophrenia-patients
#1
Anastasia Georgiades, Vicki G Davis, Alexandra S Atkins, Anzalee Khan, Trina W Walker, Antony Loebel, George Haig, Dana C Hilt, Eduardo Dunayevich, Daniel Umbricht, Michael Sand, Richard S E Keefe
The MATRICS Consensus Cognitive Battery (MCCB) was developed to assess cognitive treatment effects in schizophrenia clinical trials, and is considered the FDA gold standard outcome measure for that purpose. The aim of the present study was to establish pre-treatment psychometric characteristics of the MCCB in a large pooled sample. The dataset included 2616 stable schizophrenia patients enrolled in 15 different clinical trials between 2007 and 2016 within the United States (94%) and Canada (6%). The MCCB was administered twice prior to the initiation of treatment in 1908 patients...
April 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28424634/when-the-second-language-takes-the-lead-neurocognitive-processing-changes-in-the-first-language-of-adult-attriters
#2
Kristina Kasparian, Karsten Steinhauer
Although research on multilingualism has revealed continued neuroplasticity for language-learning beyond what was previously expected, it remains controversial whether and to what extent a second language (L2) acquired in adulthood may induce changes in the neurocognitive processing of a first language (L1). First language (L1) attrition in adulthood offers new insight on neuroplasticity and the factors that modulate neurocognitive responses to language. To date, investigations of the neurocognitive correlates of L1 attrition and of factors influencing these mechanisms are still scarce...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28398342/two-subgroups-of-antipsychotic-naive-first-episode-schizophrenia-patients-identified-with-a-gaussian-mixture-model-on-cognition-and-electrophysiology
#3
N Bak, B H Ebdrup, B Oranje, B Fagerlund, M H Jensen, S W Düring, M Ø Nielsen, B Y Glenthøj, L K Hansen
Deficits in information processing and cognition are among the most robust findings in schizophrenia patients. Previous efforts to translate group-level deficits into clinically relevant and individualized information have, however, been non-successful, which is possibly explained by biologically different disease subgroups. We applied machine learning algorithms on measures of electrophysiology and cognition to identify potential subgroups of schizophrenia. Next, we explored subgroup differences regarding treatment response...
April 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28393676/deficit-in-phonological-processes-a-characteristic-of-the-neuropsychological-profile-of-children-with-nf1
#4
Yves Chaix, Valérie Lauwers-Cancès, Nathalie Faure-Marie, Catherine Gentil, Sandrine Lelong, Elisabeth Schweitzer, Diana Rodriguez, Stéphanie Iannuzzi, Isabelle Kemlin, Nathalie Dorison, François Rivier, Maryline Carniero, Elodie Preclaire, Sébastien Barbarot, Laurence Lion-François, Pierre Castelnau
Learning disabilities are one of the most frequent complications of neurofibromatosis type 1 (NF1) in children. Studies of the effects of the neurocognitive deficit on academic performance are relatively rare, owing to the small size of the populations concerned. However, research is needed to develop effective rehabilitation programs. In the present study, we explored the impact of a possible phonological deficit on the reading abilities of children with NF1. A multicenter, cross-sectional study was conducted in France on two groups of 75 children with or without NF1 aged 8-12 years, matched for age, sex, handedness, and reading level...
April 10, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28387210/impact-of-cognition-and-clinical-factors-on-functional-outcome-in-patients-with-bipolar-disorder
#5
A Soni, P Singh, R Shah, S Bagotia
OBJECTIVE: To examine the role of different clinical variables and cognition on functional outcome in patients with bipolar disorder. METHODS: A total of 61 euthymic patients with bipolar disorder and 30 healthy individuals were included in the study. The patients were divided into low functioning (n = 30) or high functioning (n = 31) subgroups based on functioning level measured by Global Assessment of Functioning Scale score. Groups were subjected to neurocognitive and clinical assessment...
March 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/28377704/electroencephalography-eeg-in-the-study-of-equivalence-class-formation-an-explorative-study
#6
Erik Arntzen, Hanna S Steingrimsdottir
Teaching arbitrary conditional discriminations and testing for derived relations may be essential for understanding changes in cognitive skills. Such conditional discrimination procedures are often used within stimulus equivalence research. For example, the participant is taught AB and BC relations and tested if emergent relations as BA, CB, AC and CA occur. The purpose of the current explorative experiment was to study stimulus equivalence class formation in older adults with electroencephalography (EEG) recordings as an additional measure...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28374660/reward-learning-deficits-in-parkinson-s-disease-depend-on-depression
#7
M H M Timmer, G Sescousse, M E van der Schaaf, R A J Esselink, R Cools
BACKGROUND: Depression is one of the most common and debilitating non-motor symptoms of Parkinson's disease (PD). The neurocognitive mechanisms underlying depression in PD are unclear and treatment is often suboptimal. METHODS: We investigated the role of striatal dopamine in reversal learning from reward and punishment by combining a controlled medication withdrawal procedure with functional magnetic resonance imaging in 22 non-depressed PD patients and 19 PD patients with past or present depression...
April 4, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28364141/long-term-neuropsychological-outcomes-of-childhood-onset-acute-disseminated-encephalomyelitis-adem-a-meta-analysis
#8
REVIEW
Karen L O Burton, Tracey A Williams, Sarah E Catchpoole, Ruth K Brunsdon
The long-term neurocognitive prognosis of childhood onset acute disseminated encephalomyelitis (ADEM) is unclear. This review and quantitative synthesis of the available literature examined whether there are long-term impacts of childhood ADEM on neurocognitive functioning. A search of online databases (MEDLINE, EMBASE, EBSCO CINAHL, PsycINFO and the Cochrane Database of Systematic Reviews) from their inception to October 2015 and reference lists identified 13 papers eligible for inclusion in the systematic review; seven of these were eligible for inclusion in meta-analyses...
March 31, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28360787/using-neuropsychometric-measurements-in-the-differential-diagnosis-of-specific-learning-disability
#9
Sevil Turgut Turan, Emel Erdoğan Bakar, Gülsen Erden, Sirel Karakaş
INTRODUCTION: The aim of this study was to develop a neuropsychometric battery for the differential diagnosis of specific learning disability (SLD), with specific respect to attention deficit hyperactivity disorder (ADHD), and to help resolve the conflicting results in the literature by an integrative utilization of scores on both the Bannatyne categories and neuropsychological tests. METHODS: The sample included 168 primary school boys who were assigned to SLD (n=21), ADHD (n=45), SLD and ADHD (n=57), and control groups (n=45)...
June 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28358565/learning-remembering-and-predicting-how-to-use-tools-distributed-neurocognitive-mechanisms-comment-on-osiurak-and-badets-2016
#10
Laurel J Buxbaum
The reasoning-based approach championed by Francois Osiurak and Arnaud Badets (Osiurak & Badets, 2016) denies the existence of sensory-motor memories of tool use except in limited circumstances, and suggests instead that most tool use is subserved solely by online technical reasoning about tool properties. In this commentary, I highlight the strengths and limitations of the reasoning-based approach and review a number of lines of evidence that manipulation knowledge is in fact used in tool action tasks. In addition, I present a "two route" neurocognitive model of tool use called the "Two Action Systems Plus (2AS+)" framework that posits a complementary role for online and stored information and specifies the neurocognitive substrates of task-relevant action selection...
April 2017: Psychological Review
https://www.readbyqxmd.com/read/28347685/distinguishing-age-related-cognitive-decline-from-dementias-a-study-based-on-machine-learning-algorithms
#11
Füsun Er, Pınar Iscen, Sevki Sahin, Nilgun Çinar, Sibel Karsidag, Dionysis Goularas
BACKGROUND AND AIM: This study aims to examine the distinguishability of age-related cognitive decline (ARCD) from dementias based on some neurocognitive tests using machine learning. MATERIALS AND METHODS: 106 subjects were divided into four groups: ARCD (n=30), probable Alzheimer's disease (AD) (n=20), vascular dementia (VD) (n=21) and amnestic mild cognitive impairment (MCI) (n=35). The following tests were applied to all subjects: The Wechsler memory scale-revised, a clock-drawing, the dual similarities, interpretation of proverbs, word fluency, the Stroop, the Boston naming (BNT), the Benton face recognition, a copying-drawings and Öktem verbal memory processes (Ö-VMPT) tests...
March 24, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28343184/regulatory-role-of-ngfs-in-neurocognitive-functions
#12
Ashutosh Kumar, Vikas Pareek, Muneeb A Faiq, Pavan Kumar, Khursheed Raza, Pranav Prasoon, Subrahamanyam Dantham, Sankat Mochan
Nerve growth factors (NGFs), especially the prototype NGF and brain-derived neurotrophic factor (BDNF), have a diverse array of functions in the central nervous system through their peculiar set of receptors and intricate signaling. They are implicated not only in the development of the nervous system but also in regulation of neurocognitive functions like learning, memory, synaptic transmission, and plasticity. Evidence even suggests their role in continued neurogenesis and experience-dependent neural network remodeling in adult brain...
March 27, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28335872/cognitive-impairment-in-euthymic-pediatric-bipolar-disorder-a-systematic-review-and-meta-analysis
#13
REVIEW
Liana R Elias, Kamilla W Miskowiak, Antônio M O Vale, Cristiano A Köhler, Hanne L Kjærstad, Brendon Stubbs, Lars V Kessing, Eduard Vieta, Michael Maes, Benjamin I Goldstein, André F Carvalho
OBJECTIVE: To perform a systematic review and meta-analysis of studies investigating neurocognition in euthymic youths with bipolar disorder (BD) compared to healthy controls (HCs). METHOD: A systematic literature search was conducted in the PubMed/MEDLINE, PsycINFO, and EMBASE databases from inception up until March 23, 2016, for original peer-reviewed articles that investigated neurocognition in euthymic youths with BD compared to HCs. Effect sizes (ES) for individual tests were extracted...
April 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28334676/manual-motor-speed-dysfunction-as-a-neurocognitive-endophenotype-in-euthymic-bipolar-disorder-patients-and-their-healthy-relatives-evidence-from-a-5-year-follow-up-study
#14
P Correa-Ghisays, V Balanzá-Martínez, G Selva-Vera, J Vila-Francés, E Soria-Olivas, J Vivas-Lalinde, C San Martín, A M Borrás, R Ayesa-Arriola, J Sanchez-Moreno, J Sánchez-Ort, B Crespo-Facorro, E Vieta, R Tabarés-Seisdedos
BACKGROUND: Few studies have examined Manual Motor Speed (MMS) in bipolar disorder (BD). The aim of this longitudinal, family study was to explore whether dysfunctional MMS represents a neurocognitive endophenotype of BD. METHODS: A sample of 291 subjects, including 131 BD patients, 77 healthy first-degree relatives (BD-Rel), and 83 genetically-unrelated healthy controls (HC), was assessed with the Finger-Tapping Test (FTT) on three occasions over a 5-year period...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28333901/influence-of-the-recurrent-syncope-episodes-on-neurocognitive-functions-in-patients-with-vasovagal-syncope
#15
Joanna Jędrzejczyk-Spaho, Artur Z Pietrucha, Agnieszka Borowiec, Irena Bzukała, Mateusz Wnuk, Ewa Konduracka, Jadwiga Nessler
The aim of study was to evaluate an influence of recurrent syncope episodes on the neurocognitive functions (NCF) in patients with suspected VVS. AIM: The aim of study was to evaluate an influence of recurrent syncope episodes on the neurocognitive functions (NCF) in patients with suspected VVS. MATERIALS AND METHODS: Study population: 24 pts. (16 women) aged 17-70 yrs (mean age 40 years), with suspected VVS, referred to HUTT (head-up tilt test). All pts. underwent initial evaluation regarding to the number and circumstances of the syncopal and/or presyncopal spells...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28322777/preeclampsia-and-cognitive-impairment-later-in-life
#16
Julie A Fields, Vesna D Garovic, Michelle M Mielke, Kejal Kantarci, Muthuvel Jayachandran, Wendy M White, Alissa M Butts, Jonathan Graff-Radford, Brian D Lahr, Kent R Bailey, Virginia M Miller
BACKGROUND: Hypertension is a risk factor for cerebrovascular disease and cognitive impairment. Women with hypertensive episodes during pregnancy report variable neurocognitive changes within the first decade following the affected pregnancy. However, long-term follow-up of these women into their postmenopausal years has not been conducted. OBJECTIVE: The aim of this study was to examine whether women with a history of preeclampsia were at increased risk of cognitive decline 35-40 years after the affected pregnancy...
March 18, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28320844/the-effects-of-obstructive-sleep-apnea-syndrome-on-the-dentate-gyrus-and-learning-and-memory-in-children
#17
Jiook Cha, Johanna A Zea-Hernandez, Sanghun Sin, Katharina Graw-Panzer, Keivan Shifteh, Carmen R Isasi, Mark E Wagshul, Eileen E Moran, Jonathan Posner, Molly E Zimmerman, Raanan Arens
Obstructive sleep apnea syndrome (OSAS) is associated with intermittent hypoxia and sleep loss. In children, impairments of cognitive function are important manifestations, but the underlying pathology is unknown. We hypothesized that OSAS would affect the dentate gyrus, a hippocampal subdivision essential to neurogenesis and cognition, and that this impact would further affect cognitive function in children. In children with OSAS (n = 11) and control subjects (n = 12; age and sex matched), we performed diffusion tensor imaging and structural MRI, polysomnography, and neuropsychological assessments...
April 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28318904/dual-memory-neural-networks-for-modeling-cognitive-activities-of-humans-via-wearable-sensors
#18
Sang-Woo Lee, Chung-Yeon Lee, Dong-Hyun Kwak, Jung-Woo Ha, Jeonghee Kim, Byoung-Tak Zhang
Wearable devices, such as smart glasses and watches, allow for continuous recording of everyday life in a real world over an extended period of time or lifelong. This possibility helps better understand the cognitive behavior of humans in real life as well as build human-aware intelligent agents for practical purposes. However, modeling the human cognitive activity from wearable-sensor data stream is challenging because learning new information often results in loss of previously acquired information, causing a problem known as catastrophic forgetting...
February 20, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28306607/orexin-a-aggravates-the-impairment-of-hippocampal-neurons-caused-by-intermittent-hypoxemia-by-the-oxr-plc%C3%AE-1-erk1-2-pathway
#19
Guohua Li, Shi Tang, Heng Chi, Weiwei Huang, Shanshan Lu, Xin Lv, Xiaomin Liu, Yan Li, Yanpeng Wang, Jiyou Tang
Obstructive sleep apnea is a highly prevalent but under-recognized disorder that causes neurocognitive deficits such as spatial memory and learning deficits. These deficits are frequently accompanied by an increase in orexin-A, which has been shown to be involved in learning and memory as well as in neuronal apoptosis in brain areas involved in cognition, such as the hippocampus. The aim of this work was to study the possible harmful effects of orexin-A on intermittent hypoxemia-induced hippocampal neuronal damage and to investigate the potential underlying molecular mechanisms and signaling pathways in vitro...
April 12, 2017: Neuroreport
https://www.readbyqxmd.com/read/28299557/beyond-a-reading-disability-comments-on-the-need-to-examine-the-full-spectrum-of-abilities-disabilities-of-the-atypical-dyslexic-brain
#20
Jeffrey W Gilger
A panel of practioners and researchers convened to consider how to advance a broader understanding of the neurocognitive profile of people with dyslexia. While a great deal of research has been conducted on the reading process, the panel recognized that the "dyslexia brain" may be unique in other ways as well. In particular, the panel focused on complex nonverbal/spatial skills and correlated attributes such as career choice. The conclusion of the panel was that there is more to be learned about how people with dyslexia reason spatially and how these qualities manifest in academic, personal, and career behaviors...
March 15, 2017: Annals of Dyslexia
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