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JOURNAL ARTICLE
Theodoros P Vassilakopoulos, Alexia Piperidou, Zois Mellios, Evgenia Verigou, Eirini Katodritou, Christina Kalpadakis, Sotirios G Papageorgiou, Chrysovalantou Chatzidimitriou, Vassilios Prassopoulos, Marina P Siakantaris, Hara Giatra, Dimitrios Karantanis, Nikolaos Papathanasiou, Loukia Ligdi, Anastasia Kopsaftopoulou, Theoni Leonidopoulou, Vasileios Xanthopoulos, Stamatios Karakatsanis, Effimia Vrakidou, Sophia Chatziioannou, Dimitrios Drougkas, Eleftheria Hatzimichael, Gabriella Gainaru, Maria Palassopoulou, Maria Tsirogianni, Maria Kotsopoulou, Gerassimos Tsourouflis, Evangelia Skoura, Catherine Mainta, Evangelos Terpos, Christos Poziopoulos, Theodora Triantafyllou, Panayiotis Zikos, Argyro Koumarianou, Dimitra Liapi, Vassiliki Pappa, Evgenia Verrou, Panayiotis Tsirigotis, Vassiliki Labropoulou, Helen Papadaki, Ioannis Datseris, Argiris Symeonidis, Maria Bouzani, Maria Bakiri, Themis Karmiris, Maria K Angelopoulou, Phivi Rondogianni
No abstract text is available yet for this article.
November 2023: HemaSphere
#22
JOURNAL ARTICLE
Nader Kim El-Mallawany, Lisa Giulino-Roth, John M Burke, Michelle Hermiston, Carl E Allen
Pediatric non-Hodgkin lymphoma includes over 30 histologies (many with subtypes), with approximately 800 cases per year in the US, compared to >60,000 cases of adult NHL annually. Improvements in survival in pediatric and adolescent mature B cell NHL over the past 5 decades align with the overall success of the cooperative trial model with dramatic improvements in outcomes through dose escalation of chemotherapy and, more recently, targeted therapy with rituximab. Pediatric dose-intense strategies carry risks of long-term consequences, but treatment failure is nearly universally fatal...
November 2023: EJHaem
#23
REVIEW
Christian Steidl, Robert Kridel, Michael Binkley, Lindsay M Morton, Amy Chadburn
Lymphoid cancers are among the most frequent cancers diagnosed in adolescents and young adults (AYA), ranging from approximately 30%-35% of cancer diagnoses in adolescent patients (age 10-19) to approximately 10% in patients aged 30-39 years. Moreover, the specific distribution of lymphoid cancer types varies by age with substantial shifts in the subtype distributions between pediatric, AYA, adult, and older adult patients. Currently, biology studies specific to AYA lymphomas are rare and therefore insight into age-related pathogenesis is incomplete...
November 2023: EJHaem
#24
JOURNAL ARTICLE
Janet Bouttell, Heather Fraser, John R Goodlad, David Hopkins, Pam McKay, Karin A Oien, Bruce Seligmann, Stephan von Delft, Neil Hawkins
BACKGROUND AND OBJECTIVE: Adding gene expression profiles (GEPs) to the current diagnostic work-up of aggressive large B-cell lymphomas may lead to the reclassification of patients, treatment changes and improved outcomes. A GEP test is in development using TempO-Seq® technology to distinguish Burkitt lymphoma (BL) and primary mediastinal large B-cell lymphoma (PMBCL) from diffuse large B-cell lymphoma (DLBCL), and to classify patients with DLBLC and to predict the benefit of (e...
November 28, 2023: Applied Health Economics and Health Policy
#25
JOURNAL ARTICLE
Alison Hayes, Katherine Hughes, Cassia Hare, Lorraine Peschard, Armando S Lara, Luca Schiavo, Jane Dobson
A mediastinal mass was diagnosed in a 7-year-4-month-old neutered female mixed breed dog following a 3-week history of lethargy, hyporexia and pyrexia. Bi-cavitary imaging, needle aspirate cytology and flow cytometry confirmed WHO clinical stage IVb, intermediate to large T-cell lymphoma involving the mediastinum, liver and spleen. The dog initially responded to a multidrug chemotherapy protocol but clinical deterioration occurred 3 months later. The dog presented with anorexia, vomiting and diarrhoea, associated with marked faecal tenesmus and haematochezia, initially believed by the primary care practitioner to be related to chemotherapy toxicity...
November 2023: Journal of Comparative Pathology
#26
JOURNAL ARTICLE
Sanshiro Nakao, Sho Tanaka, Kazuki Abe, Tomomi Komiyama, Yoshiya Sugiura, Chiaki Nakaseko, Naomi Shimizu
In recent years, lesbian, gay, bisexual, and transgender (LGBT) populations have been gaining acceptance in society. However, very few cases of malignancy in the LGBT population have been reported thus far. We herein report a transgender woman receiving estrogen supplementation who developed primary mediastinal large B-cell lymphoma (PMBCL) and was treated with dose-adjusted EPOCH-rituximab (DA-EPOCH-R) therapy. The patient achieved complete remission after the sixth course of DA-EPOCH-R therapy. To help this LGBT patient continue receiving chemotherapy smoothly on admission, adjusting the hospital environment, such as the allocation of rooms, was essential...
November 20, 2023: Internal Medicine
#27
JOURNAL ARTICLE
Philippe Decruyenaere, Edoardo Giuili, Kimberly Verniers, Jasper Anckaert, Katrien De Grove, Malaïka Van der Linden, Dries Deeren, Jo Van Dorpe, Fritz Offner, Jo Vandesompele
INTRODUCTION: Diffuse large B-cell lymphoma (DLBCL) and primary mediastinal B-cell lymphoma (PMBCL) are aggressive histological subtypes of non-Hodgkin's lymphoma. Improved understanding of the underlying molecular pathogenesis has led to new classification and risk stratification tools, including the development of cell-free biomarkers through liquid biopsies. The goal of this study was to investigate cell-free RNA (cfRNA) biomarkers in DLBCL and PMBCL patients. MATERIALS AND METHODS: Blood plasma samples (n=168) and matched diagnostic formalin-fixed paraffin-embedded (FFPE) tissue samples (n=69) of DLBCL patients, PMBCL patients and healthy controls were collected between 2016-2021...
2023: Frontiers in Oncology
#28
JOURNAL ARTICLE
Kodai Hasegawa, Ayako Matsumura, Kengo Katsuki, Masahiro Akimoto, Takayuki Sakuma, Yuki Nakajima, Takuya Miyazaki, Shin Fujisawa, Hideaki Nakajima
A 39-year-old woman with myotonic dystrophy (DM) presented with syncope and was diagnosed with primary mediastinal large B-cell lymphoma, clinical stage IA. PET-CT revealed an upper mediastinal mass with high FDG uptake (SUVmax, 14.8). She had muscle weakness associated with DM, but her performance status was preserved. She was treated with 6 cycles of dose-adjusted EPOCH-R therapy and localized irradiation for the residual mass, without severe adverse events or recurrence of syncope. Patients with DM should be monitored for cardiac events and muscle weakness when undergoing lymphoma treatment...
2023: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
#29
JOURNAL ARTICLE
Luisa Lorenzi, Silvia Lonardi, Michela Bonezzi, Stefania Zini, Mattia Bugatti, Arianna Valzelli, Flavia Melotti, Mattia Facchetti, Iacopo Ghini, Vincenzo Villanacci, Piera Balzarini, Marco Pizzi, Viviana Giustini, Anna Galvagni, Marco Chiarini, Angelo Paolo Dei Tos, William Vermi, Stefano Casola, Fabio Facchetti
Evaluation of B-cell clonality can be challenging in the interpretation of lymphoid infiltrates on tissue sections. Clonality testing based on IG gene rearrangements analysis by PCR (IG-PCR) is the gold standard. Alternatively, B-cell clonality can be assessed by the recognition of immunoglobulin light chain (IgLC) restriction, by immunohistochemistry (IHC), chromogenic in situ hybridization (ISH) or flow cytometry (FC). IG-PCR requires molecular facilities, and FC requires cell suspensions, both not widely available in routine pathology units...
October 26, 2023: Virchows Archiv: An International Journal of Pathology
#30
Mahnosh Saleh, Noman Salih, Musa Kakakhel, Izhar Ullah, Hamza Siraj, Muhammad Naveed Tariq, Kamran Ahmad
Acute kidney injury from bilateral renal infiltration is rare in diffuse large B-cell lymphoma (DLBCL). We present the case of a 45-year-old woman with a three-month history of night sweats, weight loss, fever, and fatigue. Clinical evaluation revealed anemia, edema, cervical lymphadenopathy, and elevated blood pressure. Initial lab results indicated severe kidney injury, initially suspected to be chronic kidney disease, later ruled out. Radiological assessments confirmed mediastinal lymphadenopathy. A cervical lymph node biopsy led to a diagnosis of DLBCL...
September 2023: Curēus
#31
JOURNAL ARTICLE
Vincent Camus, Pierre-Julien Viailly, Fanny Drieux, Elena-Liana Veresezan, Pierre Sesques, Corinne Haioun, Eric Durot, Martine Patey, Cédric Rossi, Laurent Martin, Vinciane Rainville, Elodie Bohers, Philippe Ruminy, Dominique Penther, Sophie Kaltenbach, Julie Bruneau, Jérôme Paillassa, Olivier Tournilhac, Alexandre Willaume, Chloe Antier, Julien Lazarovici, Emilie Leveque, Pierre Decazes, Stéphanie Becker, David Tonnelet, Alina Berriolo-Riedinger, Philippe Gaulard, Herve Tilly, Thierry Jo Molina, Alexandra Traverse-Glehen, Fabrice Jardin
Primary mediastinal B-cell lymphoma (PMBL) is an uncommon entity of aggressive large B-cell lymphoma with an unusually good prognosis, except for 10-15% of chemorefractory cases with poor outcomes. To identify patients at high risk of chemorefractoriness, we performed molecular characterization of a retrospective multicenter cohort of PMBL patients treated with first-line immunochemotherapy. The traits of the patients with gene-expression profiling (GEP) data (n=120) were as follows: median [range] age of 34 [18-67] years, female sex 58...
October 20, 2023: Blood Advances
#32
JOURNAL ARTICLE
Marie Donzel, Florian Pesce, Alexis Trecourt, Razika Groussel, Emmanuel Bachy, Hervé Ghesquières, Juliette Fontaine, Nazim Benzerdjeb, Claire Mauduit, Alexandra Traverse-Glehen
Since the description of primary mediastinal large B-cell lymphoma (PMBL) as a distinct entity from diffuse large B-cell lymphomas (DLBCL), numerous studies have made it possible to improve their definition. Despite this, this differential diagnosis can be challenging in daily practice. However, in some centers, PMBL may be treated according to a particular regimen, distinct from those used in DLBCL, emphasizing the importance of accurate identification at diagnosis. This study aimed to describe the histological and molecular characteristics of PMBL to improve the accuracy of their diagnosis...
October 6, 2023: Cancers
#33
Yongzhen Chen, Yilun Wang, John Corrigan, Anza B Memon
Diagnosing B-cell lymphoma-associated mononeuritis multiplex is challenging due to its rarity and the potential co-existence of other causes of mononeuritis multiplex. Here, we report a case of a 74-year-old male who initially presented with left cranial neuropathies followed by right-sided extremity weakness with hyporeflexia, right facial involvement, and subsequently asymmetric weakness and multifocal muscle wasting. Minor improvements were observed with multiple rounds of steroid treatment. The diffuse large B-cell lymphoma diagnosis was eventually established six months later upon a repeat mediastinal lymph node biopsy and cerebrospinal fluid cytology...
September 2023: Curēus
#34
JOURNAL ARTICLE
C M Lanier, N Razavian, R T Hughes
PURPOSE/OBJECTIVE(S): The role of radiotherapy (RT) for diffuse large B-cell lymphoma (DLBCL) is unclear. In patients treated with upfront chemotherapy for DLBCL, indications for RT are often considered to be bulky (7.5 cm +) or extranodal disease. This is thought to improve outcomes through improvement in local control. Many trials call into question the actual benefit of RT. Alliance/CALGB 50303 was a randomized phase III trial comparing two chemotherapy regimens for the treatment for DLBCL in which no patients were to receive RT...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#35
JOURNAL ARTICLE
G Khelashvili, M Mielke, N Murphy, E D Donnelly, P Yadav, B B Mittal, I J Das
PURPOSE/OBJECTIVE(S): Hodgkin's lymphoma has been treated with combined modality therapy (chemotherapy and radiation) with a very high degree of success. Total Nodal Irradiation (TNI) performed with large AP/PA mantle fields for treatment of axillary, cervical, and mediastinal lymphatics, provide adequate coverage to the mediastinum and bilateral axillae and hila, while blocking lungs. The para-aortic and pelvic lymph nodes are treated with the so called inverted-Y AP/PA fields, which often includes the spleen in cases of TNI...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#36
JOURNAL ARTICLE
N Yegya-Raman, C M Wright, C J Ladbury, J Chew, S Zhang, S Y Sun, S Burke, J Baron, A J Sim, M J LaRiviere, J C Yang, T J Robinson, Y D Tseng, S A Terezakis, S E Braunstein, S V Dandapani, S Schuster, E A Chong, J P Plastaras, N B Figura
PURPOSE/OBJECTIVE(S): To report an ILROG multi-institutional analysis of bridging radiotherapy (BRT) prior to CD19-targeting chimeric antigen receptor T-cell (CAR T) therapy for relapsed/refractory aggressive B-cell lymphomas (BCL). MATERIALS/METHODS: Weretrospectively reviewed 115 patients (pts) with diffuse large BCL (n = 101, 88%), primary mediastinal BCL (n = 11, 10%), mantle cell lymphoma (n = 2, 2%), and T-cell/histiocyte rich large BCL (n = 1, 1%) who received BRT prior to commercial CAR T from 2018-2020 across 6 institutions...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#37
JOURNAL ARTICLE
Parviz Mardani, Mohammad Nekooeian, Saba Zangeneh, Hooman Kamran, Reza Shahriarirad, Mohammad Hossein Anbardar, Armin Amirian, Masoud Vafabin
BACKGROUND: Intrathoracic Solitary Fibrous Tumors (SFT) mainly arise from the pleura; however, these tumors may also originate from the mediastinum. We present a rare case of posterior SFT extending to several mediastinal sites and with an unusual large size, successfully treated with surgical resection. CASE PRESENTATION: A 66-year-old female presented with an initial manifestation of ambiguous pain in the chest and dysphagia and later developed pitting edema in both lower extremities and cachexia five months before admission...
September 23, 2023: Journal of Cardiothoracic Surgery
#38
Alexander T Phan, Johnny S Randhawa, Brandon Johnston, Chayanne Khosravi, Aldin Malkoc, Sarkis Arabian
Primary mediastinal B-cell lymphoma (PMBCL) is a rare subtype of non-Hodgkin lymphoma. Typical symptoms include cough, chest pain, and dyspnea; however, cardiac tamponade as the primary manifestation is exceedingly rare. We hereby present a case of a 34-year-old male with a past medical history of obesity, who presented to our emergency department with a chronic dry cough for 4 months. On admission, computed tomography demonstrated a large 11.1-cm diameter anterior mediastinal mass, and echocardiography demonstrated cardiac tamponade physiology...
August 2023: Journal of Medical Cases
#39
JOURNAL ARTICLE
Nikolaos Papathanasiou
18 F-FDG PET/CT is the imaging modality of choice for the accurate initial staging of most lymphomas. Hodgkin's, Diffuse Large B-cell and follicular lymphomas show avid FDG uptake, while a minority of Non-Hodgkin lymphoma subtypes namely MALT, marginal and small lymphocytic lymphoma demonstrate low or moderate avidity. As a rule of thumb, indolent lymphomas show lower FDG activity than aggressive ones. PET/CT has increased sensitivity in the detection of nodal involvement even in small or normal-sized nodes...
2023: Hellenic Journal of Nuclear Medicine
#40
JOURNAL ARTICLE
Manisha Uppal, Ahmad Hassan, Jalil Ahari
A female patient in her 50s presented to the hospital with a 2 months history of shortness of breath and productive cough. She also had ongoing fatigue and unintentional weight loss. Investigations demonstrated a normal white cell count and elevated lactate dehydrogenase). A CT scan of the chest revealed multiple bilateral cavitary lung masses and pulmonary nodules. Bronchoscopy with transbronchial biopsy and fine needle aspiration of mediastinal lymph node was performed. The histopathology was consistent with the non-germinal centre B cell subtype of diffuse large B cell lymphoma (DLBCL)...
August 27, 2023: BMJ Case Reports
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