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Motivation and learning

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https://www.readbyqxmd.com/read/28222000/fast-prediction-of-protein-methylation-sites-using-a-sequence-based-feature-selection-technique
#1
Leyi Wei, Pengwei Xing, Gaotao Shi, Zhi-Liang Ji, Quan Zou
Protein methylation, an important post-translational modification, plays crucial roles in many cellular processes. The accurate prediction of protein methylation sites is fundamentally important for revealing the molecular mechanisms undergoing methylation. In recent years, computational prediction based on machine learning algorithms has emerged as a powerful and robust approach for identifying methylation sites, and much progress has been made in predictive performance improvement. However, the predictive performance of existing methods is not satisfactory in terms of overall accuracy...
February 16, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28220089/emotion-regulation-therapy-a-mechanism-targeted-treatment-for-disorders-of-distress
#2
Megan E Renna, Jean M Quintero, David M Fresco, Douglas S Mennin
"Distress disorders," which include generalized anxiety disorder and major depression are often highly comorbid with each other and appear to be characterized by common temperamental features that reflect heightened sensitivity to underlying motivational systems related to threat/safety and reward/loss. Further, individuals with distress disorders tend to utilize self-referential processes (e.g., worry, rumination, self-criticism) in a maladaptive attempt to respond to motivationally relevant distress, often resulting in suboptimal contextual learning...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28216068/stages-of-dysfunctional-decision-making-in-addiction
#3
REVIEW
Antonio Verdejo-Garcia, Trevor T-J Chong, Julie C Stout, Murat Yücel, Edythe D London
Drug use is a choice with immediate positive outcomes, but long-term negative consequences. Thus, the repeated use of drugs in the face of negative consequences suggests dysfunction in the cognitive mechanisms underpinning decision-making. This cognitive dysfunction can be mapped into three stages: the formation of preferences involving valuation of decision options; choice implementation including motivation, self-regulation and inhibitory processes; and feedback processing implicating reinforcement learning...
February 16, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28213443/changes-in-appetitive-associative-strength-modulates-nucleus-accumbens-but-not-orbitofrontal-cortex-neuronal-ensemble-excitability
#4
Joseph Ziminski, Sabine Hessler, Gabriella Margetts-Smith, Meike C Sieburg, Hans S Crombag, Eisuke Koya
Cues that predict the availability of food rewards influence motivational states and elicit food-seeking behaviors. If a cue no longer predicts food availability, animals may adapt accordingly by inhibiting food seeking responses. Sparsely activated sets of neurons, coined neuronal ensembles, have been shown to encode the strength of reward-cue associations. While alterations in intrinsic excitability have been shown to underlie many learning and memory processes, little is known about these properties specifically on cue-activated neuronal ensembles...
February 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28212966/estimating-preferences-for-complex-health-technologies-lessons-learned-and-implications-for-personalized-medicine
#5
Deborah A Marshall, Juan Marcos Gonzalez, Karen V MacDonald, F Reed Johnson
We examine key study design challenges of using stated-preference methods to estimate the value of whole-genome sequencing (WGS) as a specific example of genomic testing. Assessing the value of WGS is complex because WGS provides multiple findings, some of which can be incidental in nature and unrelated to the specific health concerns that motivated the test. In addition, WGS results can include actionable findings (variants considered to be clinically useful and can be acted on), findings for which evidence for best clinical action is not available (variants considered clinically valid but do not meet as high of a standard for clinical usefulness), and findings of unknown significance...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28210781/adolescent-cocaine-exposure-enhances-goal-tracking-behavior-and-impairs-hippocampal-cell-genesis-selectively-in-adult-bred-low-responder-rats
#6
M Julia García-Fuster, Aram Parsegian, Stanley J Watson, Huda Akil, Shelly B Flagel
RATIONALE: Environmental challenges during adolescence, such as drug exposure, can cause enduring behavioral and molecular changes that contribute to life-long maladaptive behaviors, including addiction. Selectively bred high-responder (bHR) and low-responder (bLR) rats represent a unique model for assessing the long-term impact of adolescent environmental manipulations, as they inherently differ on a number of addiction-related traits. bHR rats are considered "addiction-prone," whereas bLR rats are "addiction-resilient," at least under baseline conditions...
February 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28210538/patient-and-primary-care-provider-attitudes-and-adherence-towards-lung-cancer-screening-at-an-academic-medical-center
#7
Duy K Duong, Salma Shariff-Marco, Iona Cheng, Harris Naemi, Lisa M Moy, Robert Haile, Baldeep Singh, Ann Leung, Ann Hsing, Viswam S Nair
Low dose CT (LDCT) for lung cancer screening is an evidence-based, guideline recommended, and Medicare approved test but uptake requires further study. We therefore conducted patient and provider surveys to elucidate factors associated with utilization. Patients referred for LDCT at an academic medical center were questioned about their attitudes, knowledge, and beliefs on lung cancer screening. Adherent patients were defined as those who met screening eligibility criteria and completed a LDCT. Referring primary care providers within this same medical system were surveyed in parallel about their practice patterns, attitudes, knowledge and beliefs about screening...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28210357/a-survey-of-emergency-medicine-residents-use-of-educational-podcasts
#8
Jeff Riddell, Anand Swaminathan, Monica Lee, Abdiwahab Mohamed, Rob Rogers, Salim R Rezaie
INTRODUCTION: Emergency medicine (EM) educational podcasts have become increasingly popular. Residents spend a greater percentage of their time listening to podcasts than they do using other educational materials. Despite this popularity, research into podcasting in the EM context is sparse. We aimed to determine EM residents' consumption habits, optimal podcast preferences, and motivation for listening to EM podcasts. METHODS: We created a survey and emailed it to EM residents at all levels of training at 12 residencies across the United States from September 2015 to June 2016...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28209429/nurses-experiences-of-what-constitutes-the-encounter-with-children-visiting-a-sick-parent-at-an-adult-icu
#9
Susanne Knutsson, Karin Enskär, Marie Golsäter
BACKGROUND: Despite a cultural change in visitation policies for children (0-17 years) in the intensive care unit (ICU) to a more open approach, children are still restricted from visiting for various reasons. To overcome these obstacles, it is vital to determine what is needed while encountering a child. AIM: To elucidate nurses' experiences of what constitutes the encounter with children visiting a sick parent in an adult ICU. METHOD: An explorative inductive qualitative design was used, entailing focus group interviews with 23 nurses working at a general ICU...
February 13, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28209208/food-safety-in-vietnam-where-we-are-at-and-what-we-can-learn-from-international-experiences
#10
Hung Nguyen-Viet, Tran Thi Tuyet-Hanh, Fred Unger, Sinh Dang-Xuan, Delia Grace
Food-borne diseases are attracting a lot of attention in Vietnam as a result of repeated episodes of adulterated and unsafe food. In this paper, we provide some perspectives on food safety in Vietnam from the point of view of an international research institution working on food safety with partners in the country. We argue that one of the key issues of food safety in Vietnam is that certain food value chain stakeholders lack ethics, which leads to the production and trading of unsafe foods in order to make profits irrespective of adverse health effects on consumers...
February 16, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28208882/pbl-trigger-design-by-medical-students-an-effective-active-learning-strategy-outside-the-classroom
#11
Maya Roche, Indira Kakkunje Adiga, Akshatha G Nayak
INTRODUCTION: Problem Based Learning (PBL) is known world over as an effective, active learning strategy with many benefits for the student. Usually, in medical schools, PBL triggers are designed by a well-trained group of faculty from basic and clinical sciences. The challenge was whether this task could be given to students in the first year of their curriculum and be executed by them effectively. AIM: To enhance active learning, comprehension and critical thinking with a view to promote horizontal and vertical integration between subjects...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207581/the-impact-of-an-interprofessional-oral-health-curriculum-on-trainees
#12
Oren Berkowitz, Madeline F Brisotti, Leslie Gascon, Michelle Henshaw, Laura B Kaufman
PURPOSE: Despite the prevalence of oral disease, the subject of oral health historically has been absent from medical education. We have developed an interprofessional curriculum in collaboration with our school of dentistry to teach oral health in the primary care setting to physician assistant (PA) students. The goal was to create and assess the impact of a curricular model that would be adaptable to various academic settings. METHODS: A blend of classroom, clinical skills lab, observations in the dental clinic, and observed structured clinical examinations was used to teach oral health to first-year (didactic year) PA students...
March 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28205186/optimisation-of-cognitive-performance-in-rodent-operant-touchscreen-testing-evaluation-and-effects-of-reinforcer-strength
#13
Benjamin U Phillips, Christopher J Heath, Zofia Ossowska, Timothy J Bussey, Lisa M Saksida
Operant testing is a widely used and highly effective method of studying cognition in rodents. Performance on such tasks is sensitive to reinforcer strength. It is therefore advantageous to select effective reinforcers to minimize training times and maximize experimental throughput. To quantitatively investigate the control of behavior by different reinforcers, performance of mice was tested with either strawberry milkshake or a known powerful reinforcer, super saccharin (1.5% or 2% (w/v) saccharin/1.5% (w/v) glucose/water mixture)...
February 15, 2017: Learning & Behavior
https://www.readbyqxmd.com/read/28194005/genetic-inhibition-of-neurotransmission-reveals-role-of-glutamatergic-input-to-dopamine-neurons-in-high-effort-behavior
#14
M A Hutchison, X Gu, M F Adrover, M R Lee, T S Hnasko, V A Alvarez, W Lu
Midbrain dopamine neurons are crucial for many behavioral and cognitive functions. As the major excitatory input, glutamatergic afferents are important for control of the activity and plasticity of dopamine neurons. However, the role of glutamatergic input as a whole onto dopamine neurons remains unclear. Here we developed a mouse line in which glutamatergic inputs onto dopamine neurons are specifically impaired, and utilized this genetic model to directly test the role of glutamatergic inputs in dopamine-related functions...
February 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28193135/a-longitudinal-investigation-of-the-relationship-between-motivation-and-late-second-language-speech-learning-in-classroom-settings
#15
Kazuya Saito, Jean-Marc Dewaele, Keiko Hanzawa
The current study set out to examine the role of learner motivation in second language (L2) speech learning in English-as-a-Foreign-Language classrooms. The motivational orientations of 40 first-year university Japanese students were surveyed via a tailored questionnaire and linked to their spontaneous speech development, elicited via a timed picture description task at the onset and end of one academic semester, in terms of perceived comprehensibility (i.e., ease of understanding) and accentedness (i.e., linguistic nativelikeness)...
January 1, 2017: Language and Speech
https://www.readbyqxmd.com/read/28192524/correction-linking-individual-learning-styles-to-approach-avoidance-motivational-traits-and-computational-aspects-of-reinforcement-learning
#16
Kristoffer Carl Aberg, Kimberly C Doell, Sophie Schwartz
[This corrects the article DOI: 10.1371/journal.pone.0166675.].
2017: PloS One
https://www.readbyqxmd.com/read/28191003/want-more-learn-less-motivation-affects-adolescents-learning-from-negative-feedback
#17
Yun Zhuang, Wenfeng Feng, Yu Liao
The primary goal of the present study was to investigate how positive and negative feedback may differently facilitate learning throughout development. In addition, the role of motivation as a modulating factor was examined. Participants (children, adolescents, and adults) completed two forms of the guess and application task (GAT). Feedback from the Cool-GAT task has low motivational salience because there are no consequences, while feedback from the Hot-GAT task has high motivational salience as it pertains to receiving a reward...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28188587/circadian-rhythms-and-substance-abuse-chronobiological-considerations-for-the-treatment-of-addiction
#18
REVIEW
Ian C Webb
Reward-related learning, including that associated with drugs of abuse, is largely mediated by the dopaminergic mesolimbic pathway. Mesolimbic neurophysiology and motivated behavior, in turn, are modulated by the circadian timing system which generates ∼24-h rhythms in cellular activity. Both drug taking and seeking and mesolimbic dopaminergic neurotransmission can vary widely over the day. Moreover, circadian clock genes are expressed in ventral tegmental area dopaminergic cells and in mesolimbic target regions where they can directly modulate reward-related neurophysiology and behavior...
February 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28188200/stop-think-a-simple-approach-to-encourage-the-self-assessment-of-learning
#19
Richard Guy, Bruce Byrne, Marian Dobos
A simple "stop think" approach was developed to encourage the self-assessment of learning. A key element was the requirement for students to rate their feeling of difficulty before [FOD(pre)] and after [FOD(post)] completing each of three authentic anatomy and physiology concept map exercises. The cohort was divided into low- (group L) and high-performing (group H) groups (based on final subject marks). Both FOD(pre) (group L) and FOD(post) (groups L and H) were significantly negatively correlated with score for some maps...
March 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28187726/results-and-lessons-learned-from-a-prevention-of-weight-gain-program-for-low-income-overweight-and-obese-young-mothers-mothers-in-motion
#20
Mei-Wei Chang, Roger Brown, Susan Nitzke
BACKGROUND: Mothers In Motion (MIM), a community-based lifestyle behavioral intervention, was designed and conducted to help low-income overweight and obese young mothers prevent further weight gain via promotion of stress management, healthy eating, and physical activity. This paper presents intervention effect on body weight (primary outcome) and summarizes lessons learned. METHODS: Participants (N = 612) were recruited from 7 Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) offices in Michigan and were individually randomized to an intervention n= 410) or a comparison (n =202) group (2: 1 ratio)...
February 10, 2017: BMC Public Health
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