Tianxu Liu, Qiyu He, Xinyue Yang, Yuebao Li, Disen Yuan, Qinghui Lu, Tianyu Tang, Guiwe Guan, Liwei Zheng, He Zhang, Changyou Xia, Xin Yin, Guochao Wei, Xiangmei Chen, Fengmin Lu, Lin Wang
BACKGROUND & AIMS: Hepatitis E virus (HEV), primarily genotype 1 (HEV-1), causes approximately 20.1 million infections, 44000 deaths, and 3000 stillbirths annually. Current evidence indicates that HEV-1 is only transmitted in humans. Here, we evaluated whether Mongolian gerbils can serve as animal models for HEV-1 infection. METHODS: Mongolian gerbils were used for HEV-1 and HEV-3 infection experiments. HEV infection parameters, including detection of HEV RNA and HEV antigen, liver function assessment, and histopathology, were evaluated...
April 5, 2024: Gastroenterology