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https://www.readbyqxmd.com/read/29457639/hepatitis-e-virus-infection-in-hiv-infected-patients-a-large-cohort-study-in-yunnan-province-china
#1
Shiyi Zhou, Li Ren, Xueshan Xia, Zhijiang Miao, Fen Huang, Yunlong Li, Mei Zhu, Zhenrong Xie, Yu Xu, Yuan Qian, Qiuwei Pan, Kunhua Wang
BACKGROUND & AIMS: Hepatitis E virus (HEV) infection in immunocompromised patients often results in distinct outcome, compared to the infection in general population. This study aimed to investigate the prevalence, potential risk factors and clinical features of HEV infection among HIV patients treated with antiretroviral therapy (ART) in Yunnan province, China. METHODS: A total of 770 HIV-infected patients between May 2015 and February 2016 were enrolled in Yunnan, China...
February 19, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29452164/proposal-for-a-new-subtype-of-the-zoonotic-genotype-3-hepatitis-e-virus-hev-3l
#2
Luca De Sabato, Philippe Lemey, Bram Vrancken, Lebana Bonfanti, Letizia Ceglie, Gabriele Vaccari, Ilaria Di Bartolo
The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains...
February 13, 2018: Virus Research
https://www.readbyqxmd.com/read/29450199/transfusion-transmitted-hepatitis-e-nat-screening-of-blood-donations-and-infectious-dose
#3
Jens Dreier, Cornelius Knabbe, Tanja Vollmer
The risk and importance of transfusion-transmitted hepatitis E virus (TT-HEV) infections by contaminated blood products is currently a controversial discussed topic in transfusion medicine. The infectious dose, in particular, remains an unknown quantity. In the present study, we illuminate and review this aspect seen from the viewpoint of a blood donation service with more than 2 years of experience in routine HEV blood donor screening. We systematically review the actual status of presently known cases of TT-HEV infections and available routine NAT-screening assays...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29446470/hev-and-hav-seroprevalence-in-men-that-have-sex-with-men-msm-an-update-from-milan-italy
#4
Letizia Greco, Sara Colonia Uceda Renteria, Davide Guarneri, Anna Orlandi, Antonella Zoccoli, Susanna Benardon, Marco Cusini, Giovanna Lunghi
Hepatitis E virus (HEV) is a feco-orally transmitted pathogen and one of the most common cause of acute hepatitis worldwide. Recent studies in developed countries suggested that a direct human-to-human contact such as for sexually transmitted diseases may play a significant role in the HEV spread. The aim of this study was to investigate the seroprevalence of HEV and HAV in a group of MSM, including subjects HIV and Treponema infected, in Milan, Italy. The overall anti HEV IgG seroprevalence in MSM was 10.2% (65/636), instead in the control group the detection rate was 5...
February 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29442296/first-report-of-the-presence-of-hepatitis-e-virus-in-scottish-harvested-shellfish-purchased-at-retail-level
#5
Zoe O'Hara, Claire Crossan, John Craft, Linda Scobie
Shellfish samples (n = 310) purchased from local supermarkets were analysed for the presence of hepatitis E virus (HEV) by nested RT-PCR and real-time qRT-PCR. Overall, 2.9% of samples tested positive for the presence of HEV. Phylogenetic analysis of HEV sequences revealed all as being genotype 3 HEV. This is the first report of the detection of HEV in commercially sold shellfish in Scotland. These findings may encourage further research that will help address the gaps in the knowledge in respect to foodborne transmission of HEV in Scotland and the rest of the United Kingdom...
February 13, 2018: Food and Environmental Virology
https://www.readbyqxmd.com/read/29441690/hepatitis-e-virus-infection-of-slaughtered-healthy-pigs-in-brazil
#6
A R Amorim, G S Mendes, G P A Pena, N Santos
Hepatitis E virus (HEV) is an emerging pathogen that can be transmitted through contaminated raw or undercooked meat derived from domestic pigs. HEV infections have been documented among pig herds, pig products and environmental samples raising concern about the spread of the virus. HEV genotypes 3 and 4 are considered zoonotic and have been linked to human cases. HEV was detected in 51 of 335 bile samples (15.2%) from healthy pigs in Minas Gerais, Brazil. Phylogenetic analysis of partial sequences from ORF1 and ORF2 regions yielded discordant results, assigning isolates to subtypes 3c and 3i, respectively, suggesting intragenotypic HEV recombination...
February 13, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29435117/replication-of-hepatitis-e-virus-in-the-ovary-and-promotion-of-oocyte-apoptosis-in-rabbits-infected-with-hev-4
#7
Junqing An, Tianlong Liu, Ruiping She, Qiaoxing Wu, Jijing Tian, Ruihan Shi, Wenzhuo Hao, Xinxin Ren, Yue Yang, Yiyao Lu, Yifei Yang, Yuanheng Wu
Hepatitis E virus (HEV) infection can induce infertility and miscarriage in pregnant women and infect neonates through vertical transmission. However, the mechanism of infertility and vertical transmission remains unclear. In the present study, we evaluated the replication of HEV in the ovary and structural and molecular changes induced by HEV after intraperitoneal injection of HEV in rabbits. Positive- and negative-strand HEV RNA was detected in the ovaries at 28 and 49 days post-infection. Positive HEV open reading frames 2 and 3 signals were observed in the ovaries by immunohistochemistry staining...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29433428/comparison-of-hepatitis-e-virus-seroprevalence-between-hbsag-positive-population-and-healthy-controls-in-shandong-province-china
#8
Li Zhang, Zechun Jiang, Jingjing Lv, Jiaye Liu, Bingyu Yan, Yi Feng, Li Li, Guomin Zhang, Fuzhen Wang, Aiqiang Xu
BACKGROUND: Persons with chronic hepatitis B (CHB) infection were reported to suffer severe disease after hepatitis E virus (HEV) superinfection, but the studies regarding HEV seroprevalence in this population were limited. A recent study in Vietnam found higher HEV seroprevalence among CHB patients compared with healthy controls. METHODS: A community-based case-control study was conducted in two counties of Shandong province, China, where hepatitis E incidence was at the highest (Rushan) and lowest (Zhangqiu) in the province based on data from routine public health surveillance...
February 12, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29422085/substitution-of-amino-acid-residue-v1213-in-the-helicase-domain-of-the-genotype-3-hepatitis-e-virus-reduces-virus-replication
#9
Dianjun Cao, Yan-Yan Ni, Xiang-Jin Meng
BACKGROUND: Genotype 3 hepatitis E virus (HEV) infection is generally associated with mild disease. However, recently eight genotype 3 HEV isolates were identified from patients with severe hepatitis. Importantly, three mutations (S605P, I978V and V1213A) in these genotype 3 isolates were found to be typical of genotype 4 HEV, which is sometime associated with more severe hepatitis. Therefore in this study we seek to determine if these unique mutations contribute to enhanced virus replication and thus potentially severe disease...
February 8, 2018: Virology Journal
https://www.readbyqxmd.com/read/29417054/aujeszky-s-disease-and-hepatitis-e-viruses-transmission-between-domestic-pigs-and-wild-boars-in-corsica-evaluating-the-importance-of-wild-domestic-interactions-and-the-efficacy-of-management-measures
#10
François Charrier, Sophie Rossi, Ferran Jori, Oscar Maestrini, Céline Richomme, François Casabianca, Christian Ducrot, Johan Jouve, Nicole Pavio, Marie-Frédérique Le Potier
Wildlife species as reservoirs of infectious pathogens represent a serious constraint in the implementation of disease management strategies. In the Mediterranean island of Corsica, the dynamics of hepatitis E virus (HEV) and Aujeszky's disease virus (ADV) are suspected to be influenced by interactions between wild and domestic pigs. To improve our understanding of these influences, we first compared the seroprevalences of both viruses in domestic pig populations from different locations with contrasted levels of wild-domestic interactions, ADV vaccination, biosafety, and farm husbandry...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29417024/fulminant-hepatitis-e-in-an-infant
#11
Drishti Tolani, Ira Shah
Hepatitis E virus (HEV) is an enterically transmitted infection that is typically self-limited. It spreads by fecally contaminated water within endemic areas. Hepatitis E infection occurs in both sporadic and epidemic forms in developing countries. HEV infection is usually subclinical in children but in a pregnant woman, it manifests commonly as fulminant hepatic failure. A few cases of acute liver failure caused primarily by HEV infection in children have been reported. We present a case of fulminant hepatitis E in a 1-year-old child...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29415584/management-of-chronic-viral-hepatitis-in-the-hematological-patient
#12
Laura Ambra Nicolini, Emanuela Zappulo, Claudio Viscoli, Malgorzata Mikulska
Infection with HBV and HCV represents a growing challenge in the management of patients with hematological malignancies. Recently, hepatitis E (HEV) was recognized as an endemic infection in developed countries and as an emerging health problem in immunocompromised patients. Areas covered: We reviewed the current knowledge on the impact of chronic viral hepatitis in the hematological setting. Epidemiological features, screening strategies and indications for treatment and monitoring have been explored and commented...
February 8, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29415517/distribution-of-porcine-cytomegalovirus-in-infected-donor-pigs-and-in-baboon-recipients-of-pig-heart-transplantation
#13
Uwe Fiebig, Jan-Michael Abicht, Tanja Mayr, Matthias Längin, Andrea Bähr, Sonja Guethoff, Almuth Falkenau, Eckhard Wolf, Bruno Reichart, Tomoyuki Shibahara, Joachim Denner
The porcine cytomegalovirus (PCMV) is a herpesvirus that may pose a risk for xenotransplantation using pig cells, tissues, or organs. Here, three orthotopic pig heart transplantations into baboons were studied. To detect PCMV, a real-time PCR and a Western blot assay based on four PCMV protein sequences, including two tegument proteins, were used. The transmission of PCMV from the donor pig to the recipient baboon was found in two cases, despite PCMV not being detected in the blood of the donor pigs by real-time PCR...
February 6, 2018: Viruses
https://www.readbyqxmd.com/read/29414183/hepatitis-e-outbreak-at-a-nursing-home-for-aged-people-in-hokkaido-japan-between-february-and-march-2016
#14
Setsuko Ishida, Kaori Matsuura, Shima Yoshizumi, Masahiro Miyoshi, Takahisa Sugisawa, Mitsuhiro Tanida, Motohiko Okano
BACKGROUND: Infection with hepatitis E virus (HEV) genotypes 3 and 4 are usually asymptomatic but can occasionally result in life-threatening acute hepatitis. To date, only sporadic cases together with a few outbreaks have been documented. Seroprevalence studies with assays for the detection of HEV IgG antibodies, suggest that HEV is more prevalent than previously thought, even in non-endemic regions. OBJECTIVES: The aim of this study was to characterize an outbreak of hepatitis E (HE) in a nursing home for aged people between February and March 2016...
January 29, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29410449/origin-and-dispersal-of-hepatitis-e-virus
#15
Diego Forni, Rachele Cagliani, Mario Clerici, Manuela Sironi
Hepatitis E virus (HEV, genus Orthohepevirus) is a common cause of hepatitis worldwide. Human-infecting HEV strains (Orthohepevirus A) include human-restricted and enzootic genotypes. Viruses in the Orthohepevirus A species also infect rabbits (HEV-3ra), camels, and swine. Using a selection-informed method, we dated the origin of the Orthohepevirus genus at least 21 million years ago, whereas the Orthohepevirus A species originated in Asia, most likely from a human-infecting ancestor that existed ~4500 to 6800 years ago...
February 7, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29408465/prevalence-of-hepatitis-e-virus-rna-and-antibodies-in-a-cohort-of-kidney-transplant-recipients-in-central-brazil
#16
Jerusa Marielle Nunes Seabra de Oliveira, Nara Rubia de Freitas, Sheila Araújo Teles, Fernanda de Oliveira Bottino, Andreza Sálvio Lemos, Jaqueline Mendes de Oliveira, Vanessa de Paula, Marcelo Alves Pinto, Regina Maria Bringel Martins
OBJECTIVE: To assess the prevalence of hepatitis E virus (HEV) RNA and antibodies among kidney transplant recipients (KTR) in Central Brazil. The presence of chronic HEV infection was also investigated. METHODS: A cohort study was conducted among 316 KTR treated at a referral center for kidney transplantation in Goiânia, Brazil. All serum samples were tested for the presence of HEV RNA (real-time PCR) and anti-HEV IgG/IgM (ELISA). Anti-HEV positive samples were confirmed using an immunoblot test...
February 2, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29406242/live-recombinant-lactococcuslactis-expressing-avian-hepatitis-virus-orf2-protein-immunoprotection-against-homologous-virus-challenge-in-chickens
#17
Dian Wang, Yue Zhang, Chunli Ma, Dexing Ma, Qin Zhao, Fen Wang, Yuchen Huang, Jian Li, Lili Zhang, En-Min Zhou
Avian hepatitis E virus (aHEV) is a pathogen associated with hepatitis-splenomegaly syndrome in chickens. To date, no commercial vaccine is available for preventing aHEV infection. In this study, three recombinant LactococcuslactisNZ9000experimental live vaccines expressing cytoplasmic, secreted, and cell wall-anchored forms of aHEV truncated ORF2 protein spanning amino acids 249-606 (ΔORF2) were constructed using pTX8048 vector and characterized. Each chicken was immunized three times at two-week intervals with one of the three live aHEV ORF2 vaccines (experimental group) or with live vaccine containing empty vector only (control group)...
February 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29404765/the-identification-and-characterization-of-novel-rat-hepatitis-e-virus-strains-in-bali-and-sumbawa-indonesia
#18
Putu Prathiwi Primadharsini, Mulyanto, I Dewa Nyoman Wibawa, Joko Anggoro, Tsutomu Nishizawa, Masaharu Takahashi, Suljid Jirintai, Hiroaki Okamoto
All three genetic groups of ratHEV have been found in Indonesia, suggesting the presence of additional variants of ratHEV in unexamined areas of Indonesia. A total of 242 wild rats were captured in Bali and Sumbawa, Indonesia, during 2014-2016. Among them, 4.1% were seropositive for anti-ratHEV IgG and two (0.8%) had detectable ratHEV RNA: ratESUMBAWA-140L and ratEBali2016D-047L, sharing 84.9-85.4% and 86.9-92.1% nucleotide identity with the reported G2 strains, respectively. The provisional criteria supported the notion that the ratEBali2016D-047L and ratESUMBAWA-140L strains were novel G2 variants...
February 5, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29404525/hepatitis-e-virus-replication-and-interferon-responses-in-human-placental-cells
#19
Leonard Knegendorf, Svenja A Drave, Viet Loan Dao Thi, Yannick Debing, Richard J P Brown, Florian W R Vondran, Kathrin Resner, Martina Friesland, Tanvi Khera, Michael Engelmann, Birgit Bremer, Heiner Wedemeyer, Patrick Behrendt, Johan Neyts, Thomas Pietschmann, Daniel Todt, Eike Steinmann
Hepatitis E virus (HEV) is a member of the genus Orthohepevirus in the family Hepeviridae and the causative agent of hepatitis E in humans. HEV is a major health problem in developing countries, causing mortality rates up to 25% in pregnant women. However, these cases are mainly reported for HEV genotype (gt)1, while gt3 infections are usually associated with subclinical courses of disease. The pathogenic mechanisms of adverse maternal and fetal outcome during pregnancy in HEV-infected pregnant women remain elusive...
February 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29404519/elucidating-the-differences-in-pathogenicity-between-hepatitis-e-virus-genotypes-the-quest-continues
#20
EDITORIAL
Ann-Sofie Vercouter, Philip Meuleman
No abstract text is available yet for this article.
February 2018: Hepatology Communications
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