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"hepatitis e"

Verena Klämbt, Marcus Panning, Maximilian Seidl, Karsten Häffner, Martin Pohl
HEV infection can lead to chronic hepatitis in immunosuppressed patients; extrahepatic manifestations are rarely seen. Here, we report a 13-year-old renal transplant patient with chronic hepatitis E and renal involvement. Ribavirin therapy led to temporary virus clearance and amelioration of kidney function. However, ribavirin therapy caused severe hyporegenerative anemia, which has so far only been reported in patients treated with a combination of ribavirin and interferon alpha.
April 17, 2018: Pediatric Transplantation
Caroline Charre, Christophe Ramière, Jérôme Dumortier, Florence Abravanel, Sébastien Lhomme, Rodica Gincul, Caroline Scholtès
Acute hepatitis E virus infection during pregnancy has a high fatality rate in developing countries. Little data are available on chronic infection in pregnant women. We report a case of chronic hepatitis E during treatment with infliximab and azathioprine, without adverse event during pregnancy and with spontaneous resolution after delivery.
May 2018: Emerging Infectious Diseases
Selam Niguse, Haftamu Hailekiros, Gerezgiher Buruh, Tadese Dejene, Nega Berhe, Tsehaye Asmelash
Existing literatures from developing countries show an increased mortality and morbidity related to hepatitis E virus during pregnancy as compared to the general population. Studies focusing on pregnant women are required for policy makers to improve maternal and child health. Therefore this study is aimed at determining the prevalence and associated risk factors of hepatitis E virus infection among pregnant women attending the health facilities of Tigray region, Northern Ethiopia. In this cross sectional study 846 pregnant women were included consecutively from April 2014 to February 2016...
April 16, 2018: Journal of Medical Virology
Thomas Horvatits, Ann-Kathrin Ozga, Dirk Westhoelter, Johannes Hartl, Carolin Manthey, Marc Lütgehetmann, Geraldine Rauch, Levente Kriston, Ansgar W Lohse, Richard Bendall, Heiner Wedemeyer, Harry R Dalton, Sven Pischke
BACKGROUND & AIMS: While hepatitis E virus (HEV) infections are a relevant topic in Europe, knowledge about epidemiology of HEV infections in the USA and Latin America is still limited. Aim of this study was to estimate anti-HEV IgG seroprevalence in the Americas and to assess whether low socioeconomic status is associated with HEV exposure. METHODS: We performed a systematic review and meta-analysis. Literature search was performed in PubMed for articles published 01/1994-12/2016...
April 16, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
A Rivero-Juarez, M Frias, P Lopez-Lopez, A Martinez-Peinado, M Á Risalde, T Brieva, I Machuca, Á Camacho, I García-Bocanegra, J C Gomez-Villamandos, A Rivero
Diagnosis of acute hepatitis E virus (HEV) infection is established by detection of anti-HEV IgM antibodies by ELISA or by amplification of serum viral RNA. Here, we evaluate the diagnostic value of testing HEV RNA in saliva to identify patients with acute HEV infection. Prospective proof-of-concept study including patients with acute hepatitis. Whole blood and neat saliva samples were obtained from all patients. Saliva samples were processed and analysed for HEV RNA by RT-PCR within 2 hr after collection...
April 16, 2018: Zoonoses and Public Health
Meng-Jie Bai, Na Zhou, Wei Dong, Guang-Xing Li, Wei Cong, Xing-Quan Zhu
OBJECTIVES: Hepatitis E virus (HEV) is a single-stranded RNA virus infecting a variety of animals and humans. However, little is known of HEV infection among cancer patients in China. This study provides new epidemiological data for the prevalence of co-infection of HEV in cancer patients, indicating that HEV infection is common in this group. METHODS: We recruited a total of 950 cancer patients and 950 control volunteers from Shandong Province, eastern China, to participate in our investigation...
April 12, 2018: International Journal of Infectious Diseases: IJID
H Fenaux, M Chassaing, S Berger, H Jeulin, A Gentilhomme, M Bensenane, J P Bronowicki, C Gantzer, I Bertrand, E Schvoerer
BACKGROUND AND OBJECTIVES: Hepatitis E virus (HEV) is emerging but its circulation between humans and the environment remains misunderstood. HEV ORF2 gene encodes the capsid playing a key role in viral interactions with surfaces, ORF3 products are involved in the viral cycle. Our aim was to study the molecular characteristics of ORF2 and ORF3 which could favor HEV fitness in patients and the environment. STUDY DESIGN: Samples from 69 patients with hepatitis (blood/stools), 20 urban wastewaters, 20 effluents of a pig slaughterhouse, 22 farm pigs (stools), 20 wild boars (liver/stools) were collected in North-Eastern France...
April 5, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
M Allaire, C Bazille, J Selves, E Salamé, M Altieri
INTRODUCTION: In liver transplant (LT) patients, hepatitis E virus (HEV) can lead to acute liver failure, chronic hepatitis and graft cirrhosis. Few data on graft rejection associated with HEV are available and are subject to discussion. CASE REPORT: Here we report the case of a 58-year-old male patient who underwent LT in July 2015 for cirrhosis due to NASH and chronic alcohol intake complicated by hepatocellular carcinoma. LT was performed with a deceased donor isogroup and a mismatch CMV (donor+ and recipient-)...
April 10, 2018: Clinics and Research in Hepatology and Gastroenterology
Claude Kwe Yinda, Stephen Mbigha Ghogomu, Nádia Conceição-Neto, Leen Beller, Ward Deboutte, Emiel Vanhulle, Piet Maes, Marc Van Ranst, Jelle Matthijnssens
Most human emerging infectious diseases originate from wildlife and bats are a major reservoir of viruses, a few of which have been highly pathogenic to humans. In some regions of Cameroon, bats are hunted and eaten as a delicacy. This close proximity between human and bats provides ample opportunity for zoonotic events. To elucidate the viral diversity of Cameroonian fruit bats, we collected and metagenomically screened eighty-seven fecal samples of Eidolon helvum and Epomophorus gambianus fruit bats. The results showed a plethora of known and novel viruses...
January 2018: Virus Evolution
Siddharth Sridhar
I read with interest the work by Drave et al on the replication of hepatitis E virus (HEV) in neuronal cell lines (1). HEV is increasingly associated with a range of neurological manifestations including Guillain Barre Syndrome, neuralgic amyotrophy and encephalitis (2). Therefore, in-vitro work on this subject is timely and important. This article is protected by copyright. All rights reserved.
April 6, 2018: Journal of Viral Hepatitis
Z Yang, Y Hu, P Yuan, Y Yang, K Wang, L Y Xie, S L Huang, J Liu, L Ran, Z H Song
In the swine hepatitis E virus (HEV), open reading frame 2 (ORF2) is rich in antigenic determinants and neutralizing epitopes that could induce immune protection. We chose the Bac-to-Bac® Baculovirus Expression System to express fragments containing the critical neutralizing antigenic sites within the HEV ORF2 protein of pigs to obtain a recombinant baculovirus. The fragment of swine HEV ORF2 region (1198-1881bp) was cloned into vector pFastBacTM. A recombinant baculovirus, rBacmid-ORF2, was obtained after transposition and transfection...
March 2018: Polish Journal of Veterinary Sciences
Nicola J King, Joanne Hewitt, Anne-Marie Perchec-Merien
Historically in developed countries, reported hepatitis E cases were typically travellers returning from countries where hepatitis E virus (HEV) is endemic, but now there are increasing numbers of non-travel-related ("autochthonous") cases being reported. Data for HEV in New Zealand remain limited and the transmission routes unproven. We critically reviewed the scientific evidence supporting HEV transmission routes in other developed countries to inform how people in New Zealand may be exposed to this virus...
April 5, 2018: Food and Environmental Virology
Shahid Faraz Syed, Qin Zhao, Muhammad Umar, Mahmoud Alagawany, Imtiaz Ahmed Ujjan, Feroza Soomro, Nasrullah Bangulzai, Abdul Hameed Baloch, Mohamed Abd El-Hack, En-Min Zhou, Muhammad Asif Arain
The origin of hepatitis E virus (HEV) is not fully understood, but it is considered an emerging zoonotic pathogen. To date, HEV has been isolated from many animal species. The family Hepeviridae consists of two genera. The genus Orthohepevirus includes four distinct species (A, B, C, and D), each with distinct genotypes. Within the Orthohepevirus A species, HEV-1 and HEV-2 host ranges are restricted to humans, whereas genotypes 3 and 4 primarily infect a wide range of diverse animal species, in addition to being zoonotic to humans...
April 2, 2018: Microbial Pathogenesis
Yifei Yang, Ruihan Shi, Majid H Soomro, Fengjiao Hu, Fang Du, Ruiping She
Previous studies demonstrated that Mongolian gerbils can be infected by hepatitis E virus (HEV), which induces the hepatic injury. Here, the mitochondria in hepatocytes from HEV-infected gerbils were considerably swollen, thin cristae. After HEV infection, the activity of superoxide dismutase significantly decreased ( p < 0.01), while malondialdehyde concentrations significantly increased, compared with those in the control group ( p < 0.01). Adenosine triphosphatase levels decreased significantly in the hepatocyte of the inoculated groups, compared with those in control group ( p < 0...
2018: Frontiers in Microbiology
Bin Zhu, Jinlin Liu, Yang Fu, Bo Zhang, Ying Mao
Viral hepatitis, as one of the most serious notifiable infectious diseases in China, takes heavy tolls from the infected and causes a severe economic burden to society, yet few studies have systematically explored the spatio-temporal epidemiology of viral hepatitis in China. This study aims to explore, visualize and compare the epidemiologic trends and spatial changing patterns of different types of viral hepatitis (A, B, C, E and unspecified, based on the classification of CDC) at the provincial level in China...
April 2, 2018: International Journal of Environmental Research and Public Health
Krzysztof Korzeniewski
Travelling during pregnancy has become increasingly common. Many pregnant women travel for pleasureand recreation and a lot of them continue to work and therefore often travel on business, sometimes to areas with poor standards of sanitation and limited access to health care providers. During pregnancy, it is extremely important that a woman has a regular access to maternal health care, also in temporary destinations, especially in areas characterised by harsh environmental conditions, and places where the prevalence of infectious diseases is high...
2018: International Maritime Health
Anna-Lena Sander, Victor Max Corman, Alexander N Lukashev, Jan Felix Drexler
The enterically transmitted hepatitis A (HAV) and hepatitis E viruses (HEV) are the leading causes of acute viral hepatitis in humans. Despite the discovery of HAV and HEV 40-50 years ago, their evolutionary origins remain unclear. Recent discoveries of numerous nonprimate hepatoviruses and hepeviruses allow revisiting the evolutionary history of these viruses. In this review, we provide detailed phylogenomic analyses of primate and nonprimate hepatoviruses and hepeviruses. We identify conserved and divergent genomic properties and corroborate historical interspecies transmissions by phylogenetic comparisons and recombination analyses...
April 2, 2018: Cold Spring Harbor Perspectives in Medicine
(no author information available yet)
Infection with hepatitis E virus (HEV) is a significant cause of morbidity and mortality, representing an important global health problem. Our understanding of HEV has changed completely over the past decade. Previously, HEV was thought to be limited to certain developing countries. We now know that HEV is endemic in most high-income countries and is largely a zoonotic infection. Given the paradigm shift in our understanding of zoonotic HEV and that locally acquired HEV is now the commonest cause of acute viral hepatitis in many European countries, the focus of these Clinical Practice Guidelines will be on HEV genotype 3 (and 4)...
March 31, 2018: Journal of Hepatology
Y Cheng, X F Liu, L Meng, X T Yang, D P Liu, K F Wei, X J Jiang, H X Liu, Y H Zheng
Objective: To optimize the warning threshold values of common communicable diseases in Gansu province, and improve the early warning effect. Method: An early warning model was set up for influenza, scarlet fever, other infectious diarrheal diseases, dysentery, typhoid and paratyphoid, viral hepatitis type E and hand foot and mouth disease (HFMD) respectively in Gansu by using the moving percentile method and cumulative sum method. By calculating the sensitivity, specificity, predictive value of positive test, predictive value of negative test, Youden' index and receiver-operating characteristic curve, the optimum early warning threshold values for communicable diseases in Gansu were selected...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Daniel Sedhom, Melroy D'Souza, Elizabeth John, Vinod Rustgi
Although the overall prevalence is on the decline, viral hepatitis still plays a major role in the development of acute liver failure (ALF) worldwide. Hepatitis A, B, D, and E contribute to most fulminant viral courses. These viruses have not gained much attention in recent years yet remain relevant from a clinical perspective as the incidence in certain populations is on the increase. Other viral therapies and immunotherapies are currently being examined as treatments for hepatitis D and hepatitis E. Clinicians should still maintain a high index of suspicion for viral causes in approaching patients with ALF...
May 2018: Clinics in Liver Disease
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