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https://www.readbyqxmd.com/read/27922197/variability-in-the-performance-characteristics-of-igg-anti-hev-assays-and-its-impact-on-reliability-of-seroprevalence-rates-of-hepatitis-e
#1
Maja Kodani, Nourine Ahmed, Alexandra Tejada-Strop, Amanda Poe, Maxine M Denniston, Jan Drobeniuc, Saleem Kamili
Hepatitis E is a major public health problem in developing countries and is increasingly being recognized as a cause of substantial sporadic viral hepatitis infections in industrialized countries. Variable rates of hepatitis E seroprevalence have been reported from the same geographic regions depending on the assay used. In this study, we evaluated the performance characteristics of four assays which included two commercial assays, Wantai HEV-IgG ELISA kit (Wantai, China) and DS-EIA-ANTI-HEV-G kit (DSI, Italy), one NIH-developed immunoassay (NIH-55K, Kuniholm et al...
December 6, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27922191/full-length-genomic-sequence-analysis-of-new-subtype-3k-hepatitis-e-virus-isolates-with-99-97-nucleotide-identity-obtained-from-two-consecutive-acute-hepatitis-patients-in-a-city-in-northeast-japan
#2
Masahito Miura, Jun Inoue, Mio Tsuruoka, Tsutomu Nishizawa, Shigeo Nagashima, Masaharu Takahashi, Tooru Shimosegawa, Hiroaki Okamoto
Full-length genomic sequences of hepatitis E virus (HEV) obtained from two consecutive cases of acute self-limiting hepatitis E in a city in northeast Japan were determined. Interestingly, two HEV isolates from each patient shared nucleotide identity of 99.97% in 7,225 nucleotides, and a phylogenetic analysis showed that they formed a cluster of Japanese isolates that is considered as a new HEV subtype 3k. The high similarity of HEV sequences of two isolates from these patients in this study suggested that a subtype 3k HEV strain had spread via a commonly distributed food in the city, possibly pig liver...
December 6, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27919006/assessment-of-the-risk-of-foodborne-transmission-and-burden-of-hepatitis-e-in-switzerland
#3
Alexandra Müller, Lucie Collineau, Roger Stephan, Andrea Müller, Katharina D C Stärk
The objective of this study was i) to quantify the risk of hepatitis E for Swiss consumers by specified pork products and ii) to estimate the total burden of human food-borne hepatitis E in Switzerland. A quantitative risk assessment from slaughter to consumption was carried out according to the Codex Alimentarius framework. In the hazard characterization, assumptions were made due to the lack of a dose-response relationship for oral exposure to hepatitis E virus (HEV). The prevalence of HEV in 160 pig livers of 40 different Swiss fattening farms was examined and determined to be 1...
November 22, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27917096/hepatitis-e-virus-infection-and-cirrhosis-of-the-liver
#4
Jean-Marie Péron
No abstract text is available yet for this article.
September 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27913223/hepatitis-e-virus-infection-beyond-the-liver
#5
REVIEW
S Pischke, J Hartl, S D Pas, A W Lohse, B C Jacobs, A A van der Eijk
Hepatitis E virus (HEV) infections are not limited to the liver but may also affect other organs. Several diseases, including Guillain-Barré syndrome, neuralgic amyotrophy, glomerulonephritis, cryoglobulinemia, pancreatitis, lymphoma, thrombopenia, meningitis, thyreoiditis and myocarditis have been observed in the context of hepatitis E. To date the definite pathophysiological links between HEV and extrahepatic manifestations are not yet established. However, it is suggested that HEV-infection might be causative based on serological studies, case series, in vitro data and animal models...
November 29, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27911040/retrospective-study-evaluating-seroprevalence-of-hepatitis-e-virus-in-blood-donors-and-in-swine-veterinarians-in-italy-2004
#6
L De Sabato, I Di Bartolo, E Montomoli, C Trombetta, F M Ruggeri, F Ostanello
Hepatitis E is an emerging viral disease in developed countries, with sporadic cases occasionally linked to the consumption of raw or undercooked pork, wild boar or deer meat. Cases due to transfusion or transplantation have also been reported. In developed countries, hepatitis E is considered a zoonosis and pig is the main reservoir. In the last few years, several studies conducted in Europe reported variable seroprevalence rates among the general population, ranging between 0.26% and 52.5%. A higher seroprevalence was described among workers who come in contact with pigs...
December 2, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27899274/systematic-identification-of-hepatitis-e-virus-orf2-interactome-reveals-that-tmem134-engages-in-orf2-mediated-nf-%C3%AE%C2%BAb-pathway
#7
Yabin Tian, Weijin Huang, Jun Yang, Zhiheng Wen, Yansheng Geng, Chenyan Zhao, Heqiu Zhang, Youchun Wang
Hepatitis E virus (HEV) is the causative agent of acute hepatitis E. Open reading frame 2 (ORF2) encodes the capsid protein of HEV, which is the main structural protein and may participate, together with the host factors, in viral entry and egress. However, it is still not clear which host proteins are involved in the interaction with ORF2 and what the functions of these ORF2-interacting proteins are. In this study, we have applied a split-ubiquitin yeast two-hybrid screening approach in combination with the pull-down and coimmunoprecipitation assays, identified and validated multiple interacting partners of ORF2 of genotype 1 and 4, which have diverse biological functions...
November 27, 2016: Virus Research
https://www.readbyqxmd.com/read/27893287/hepatitis-e-virus-in-wild-boar-in-northwest-poland-sensitivity-of-methods-of-detection
#8
Samart Dorn-In, Karin Schwaiger, Magdalena Twarużek, Jan Grajewski, Christoph Gottschalk, Manfred Gareis
In northwest Poland, 163 blood and 53 fecal samples of wild boars were collected in winter 2012/13 and 2013/14. All blood samples were tested for the presence of hepatitis E virus (HEV) ribonucleic acid (RNA) by two reverse transcription-polymerase chain reaction (RT-PCR) based methods and by anti-HEV IgG enzyme-linked immunosorbent assay (ELISA). About 17.2% of blood samples were seropositive. One-step nested RT-PCR turned out to be too insensitive (11.6% were positive). Therefore a two-step nested RT-PCR was applied where 25...
November 28, 2016: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/27891290/a-comparative-study-of-assay-performance-of-commercial-hepatitis-e-virus-enzyme-linked-immunosorbent-assay-kits-in-australian-blood-donor-samples
#9
Ashish C Shrestha, Robert L P Flower, Clive R Seed, Susan L Stramer, Helen M Faddy
Hepatitis E virus (HEV) is transfusion-transmissible and therefore poses a risk to blood transfusion safety. Seroprevalence studies are useful for estimating disease burden and determining risk factors. Considerable variability in the sensitivity of HEV antibody detection assays exists. This study aimed to compare the performances of commercially available HEV enzyme-linked immunosorbent assays (ELISA) in Australian blood donor samples. Plasma samples that tested positive (n = 194) or negative (n = 200) for HEV IgG (Wantai HEV IgG ELISA) were selected...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27890632/evidence-of-genotypes-1-and-3-of-avian-hepatitis-e-virus-in-wild-birds
#10
Xinquan Zhang, Ivana Bilic, Salome Troxler, Michael Hess
Although the presence of four genotypes of avian hepatitis E virus (HEV) in chickens has been demonstrated, its natural host range is still barely known. In this study, swab samples from 626 wild birds originating from 62 bird species were investigated for HEV detection by molecular methods. The aim was to explore the cross-species infection of avian HEV and to compare the genetic diversity between strains infecting chicken and wild birds. In total, 8 positive samples from 4 different bird species (song thrush, little owl, feral pigeon and common buzzard) were identified and further confirmed by partial sequencing of ORF3...
November 25, 2016: Virus Research
https://www.readbyqxmd.com/read/27887586/hepatitis-e-virus-seroepidemiology-a-post-earthquake-study-among-blood-donors-in-nepal
#11
Ashish C Shrestha, Robert L P Flower, Clive R Seed, Manita Rajkarnikar, Shrawan K Shrestha, Uru Thapa, Veronica C Hoad, Helen M Faddy
BACKGROUND: As one of the causative agents of viral hepatitis, hepatitis E virus (HEV) has gained public health attention globally. HEV epidemics occur in developing countries, associated with faecal contamination of water and poor sanitation. In industrialised nations, HEV infections are associated with travel to countries endemic for HEV, however, autochthonous infections, mainly through zoonotic transmission, are increasingly being reported. HEV can also be transmitted by blood transfusion...
November 25, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27885564/hepatitis-e-virus-infection-in-patients-on-dialysis-and-in-solid-organ-transplant-recipients-in-argentina-exploring-associated-risk-factors
#12
María Belén Pisano, Domingo Balderramo, Maribel Martínez Wassaf, Martín Lotto, Yanina Carlino, Viviana Elizabeth Ré, José D Debes
Infection with hepatitis E virus (HEV) leads to acute hepatitis infection in immunocompetent hosts. HEV genotype 3 can present with high frequency and lead to chronic infection in individuals with a compromised immune system. The risk factors related to increased seroprevalence or chronicity in this population are not entirely understood. Moreover, most studies addressing risk factors for HEV in non-endemic areas come from developed areas such as North America and Europe. In this study we evaluated seroprevalence, chronicity and risk factors for HEV in 120 transplant recipients and 88 patients on dialysis in Argentina...
November 25, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27876615/a-novel-avian-like-hepatitis-e-virus-in-wild-aquatic-bird-little-egret-egretta-garzetta-in-hungary
#13
Gábor Reuter, Ákos Boros, Róbert Mátics, Beatrix Kapusinszky, Eric Delwart, Péter Pankovics
Hepatitis E virus (HEV), family Hepeviridae, has public health concerns because of its zoonotic potential; however, the host species spectrum, animal to animal transmissions, the natural chain of hepevirus infections and the genetic diversity of HEV in wildlife especially in birds are less known. Using random amplification and next generation sequencing technology a genetically divergent avian HEV was serendipitously identified in wild bird in Hungary. HEV RNA was detected with high faecal viral load (1.33×10(8)genomiccopies/ml) measured by real-time PCR in faecal sample from a little egret (Egretta garzetta)...
December 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27876045/seroprevalence-of-avian-hepatitis-e-virus-and-avian-leucosis-virus-subgroup-j-in-chicken-flocks-with-hepatitis-syndrome-china
#14
Yani Sun, Taofeng Du, Baoyuan Liu, Shahid Faraz Syed, Yiyang Chen, Huixia Li, Xinjie Wang, Gaiping Zhang, En-Min Zhou, Qin Zhao
BACKGROUND: From 2014 to 2015 in China, many broiler breeder and layer hen flocks exhibited a decrease in egg production and some chickens developed hepatitis syndrome including hepatomegaly, hepatic necrosis and hemorrhage. Avian hepatitis E virus (HEV) and avian leucosis virus subgroup J (ALV-J) both cause decreasing in egg production, hepatomegaly and hepatic hemorrhage in broiler breeder and layer hens. In the study, the seroprevalence of avian HEV and ALV-J in these flocks emerging the disease from Shandong and Shaanxi provinces were investigated...
November 22, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27861224/neuralgic-amyotrophy-associated-with-hepatitis-e-virus-infection-first-case-in-the-united-states
#15
Jose D Avila, David Lacomis, Erek M Lam
Hepatitis E is an emerging viral infection in developed countries. It can present with multiple extra-hepatic manifestations, including neuralgic amyotrophy. We report a 52-year-old man who presented with neck and shoulder pain followed by orthopnea and left arm weakness. Electrodiagnostic testing showed left phrenic neuropathy and denervation in bilateral C5 and C6 myotomes. He also had elevated liver enzymes, which led to the diagnosis of acute hepatitis E. This is the first case of neuralgic amyotrophy associated with hepatitis E in the United States...
December 2016: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/27853931/hepatitis-e-virus-genotype-3-in-slurry-samples-from-swine-farming-activities-in-italy
#16
G La Rosa, S Della Libera, M Brambilla, C Bisaglia, G Pisani, A R Ciccaglione, R Bruni, S Taffon, M Equestre, M Iaconelli
Hepatitis E virus (HEV) is an emergent causative agent of acute hepatitis, transmitted by fecal-oral route. Infection with HEV is a global cause for morbidity and mortality throughout the world: it mainly causes large outbreaks in endemic areas and sporadic autochthonous cases in industrialized countries where HEV infections seem to be an emergent zoonotic disease. Infection of porcine livestock and its relationship with the human cases have been demonstrated. The present study describes an investigation on the prevalence and diversity of HEV in pig slurry in Italy...
November 16, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27843081/hepatitis-e-virus-emerging-from-the-shadows-in-developed-countries
#17
REVIEW
Harry R Dalton, Jerard Seghatchian
Following the discovery of HEV in the 1980s, it became apparent that HEV is endemic in a number of developing countries in Asia, Africa and Mexico. In these geographical settings HEV is spread oral faecally by HEV genotypes (gt) 1 and 2, which are obligate human pathogens. Infection occurs oro-faecally, often as a result in the breakdown of fragile sanitary infrastructure allowing drinking water supplies to become contaminated with human sewage. Hepatitis E usually causes a self-limiting hepatitis in young adults with sporadic cases and occasional dramatic outbreaks involving hundreds or thousands of cases...
November 1, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27836843/waterborne-viruses-and-f-coliphage-in-mixed-use-watersheds-microbial-associations-host-specificity-and-affinities-with-environmental-land-use-factors
#18
Tineke H Jones, Julie Brassard, Edward Topp, Graham Wilkes, David R Lapen
: From years 2008 to 2014, a total of 1155 water samples were collected (spring-fall) from 24 surface water sampling sites located on mixed-used but predominantly agricultural (i.e., dairy livestock production) watersheds in eastern Ontario, Canada. Water was analyzed for viable F-DNA and F-RNA (GI-GIV) coliphage and a suite of molecularly detected viruses (norovirus (GI-GIV), TTV, rotavirus, kobuvirus, adenovirus, astrovirus, hepatitis A, and hepatitis E). F-DNA and FRNA coliphage were detected in 33 and 28% of the samples at maximum concentrations of 2000 and 16300 PFU 100 mL(-1), respectively...
November 11, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27836809/persistence-of-antibodies-acquired-by-natural-hepatitis-e-virus-infection-and-the-effects-of-vaccination
#19
Yingying Su, Shoujie Huang, Meng Guo, Jun Zhao, Huan Yu, Wengang He, Hanmin Jiang, Yijun Wang, Xuefeng Zhang, Jiaping Cai, Changlin Yang, Zhongze Wang, Fengcai Zhu, Ting Wu, Jun Zhang, NingShao Xia
OBJECTIVES: Naturally acquired anti-hepatitis E virus (HEV) immunity can protect against new HEV infections. The aim of this study was to analyze the persistence of naturally acquired anti-HEV IgG and anti-HEV IgG concentrations after vaccination. METHODS: We examined the seropositivity rates of participants included in a phase III clinical efficacy trial (67 months follow-up) for a HEV vaccine (Hecolin(®)) and predicted long-term persistence using mixed-effect models...
November 8, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27836355/exacerbation-of-hepatitis-e-virus-infection-during-anti-tnf%C3%AE-treatment
#20
Patrick Behrendt, Stefan Lüth, Werner Dammermann, Svenja Drave, Richard J P Brown, Daniel Todt, Ulrike Schnoor, Eike Steinmann, Heiner Wedemeyer, Sven Pischke, Christof Iking-Konert
Chronic hepatitis E virus (HEV) infection may occur in immunocompromised patients. Previous studies report that different immunosuppressive agents interfere with viral replication. However, the role of TNFα in HEV infection is currently unknown. Here, we describe a case of severe exacerbation of a chronic HEV infection in a patient undergoing treatment with a TNFα-inhibitor for psoriatic arthritis despite potent anti-HEV T-cell responses. We used state-of-the-art HEV cell culture methods to test antiviral effects of different drugs and a cytokine release assay to assess HEV specific T cell immunity...
November 8, 2016: Joint, Bone, Spine: Revue du Rhumatisme
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