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https://www.readbyqxmd.com/read/29226766/a-case-report-of-living-donor-liver-transplantation-for-fulminant-hepatitis-related-to-hepatitis-e-virus-infection
#1
Keita Shimata, Yasuhiko Sugawara, Hidekazu Yamamoto, Hiroaki Okamoto, Koushi Uchida, Seiichi Kawabata, Kaori Isono, Shintaro Hayashida, Yukihiro Inomata
Hepatitis E virus (HEV) infection which may become fulminant, especially in elderly people is more common than previously recognized in develop countries. Here we report successful living-donor liver transplantation (LDLT) in a case of acute liver failure due to HEV. A 63-year-old Japanese man with no previous history of liver disease was admitted for severe acute hepatitis. Detection of anti-HEV immunoglobulin A established a diagnosis of this virus-related liver failure. The patient suffered from hepatic encephalopathy 10 days after symptom onset and underwent LDLT...
January 1, 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29226104/hepatitis-e-a-literature-review
#2
REVIEW
Juliana Ayres de Alencar Arrais Guerra, Katia Cristina Kampa, Daphne Gonçalves Benatti Morsoletto, Alcindo Pissaia Junior, Cláudia Alexandra Pontes Ivantes
Hepatitis E is the fifth known form of human viral hepatitis. Although not very common in our clinical practice, the incidence in Western countries is increasing. Infection with the hepatitis E virus (HEV) may be related to acute illness, liver failure, chronic hepatitis and cirrhosis. HEV itself is an RNA virus, with eight described genotypes (HEV 1-8), four of which more commonly affect humans and have, thus, been better studied. Besides liver manifestations, genotype 3 is also related to extra-hepatic manifestations, such as neurological, renal and rheumatological...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29214558/hepatitis-e-seroprevalence-and-genotyping-in-a-cohort-of-wild-boars-in-southern-germany-and-eastern-alsace
#3
Kilian Weigand, Kurt Weigand, Mathias Schemmerer, Martina Müller, Juergen J Wenzel
In the last few years it has been realized that the hepatitis E virus (HEV) is endemic in most industrialized countries and that it is a zoonotic disease. Potential reservoirs for HEV have been identified to be wild boars and deers, but HEV has also been found in domestic pigs and other animals. Due to the probable spread of the virus via contaminated food or contact to infected animals, HEV antibodies are present in more than 16% of the German adult population and rates are increasing with age. We collected blood from 104 wild boars in southern Germany and the border region of Alsace...
December 6, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/29214492/an-ethanol-extract-of-lysimachia-mauritiana-exhibits-inhibitory-activity-against-hepatitis-e-virus-genotype-3-replication
#4
Seong Eun Jin, Jung-Eun Kim, Sun Yeou Kim, Bang Ju Park, Yoon-Jae Song
Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon...
December 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29213060/structural-characterization-of-site-modified-nanocapsid-with-monodispersed-gold-clusters
#5
Marie C Stark, Mo A Baikoghli, Tanja Lahtinen, Sami Malola, Li Xing, Michelle Nguyen, Marina Nguyen, Aria Sikaroudi, Varpu Marjomäki, Hannu Häkkinen, R Holland Cheng
Hepatitis E Virus-like particles self-assemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions. Previously, the nanocapsid was engineered to specifically bind and enter breast cancer cells, where successful tumor targeting was demonstrated in animal models. In the present study, the nanocapsid surface was modified with a solvent-exposed cysteine to conjugate monolayer protected gold nanoclusters (AuNC). Unlike commercially available gold nanoparticles, AuNCs monodisperse in water and are composed of a discrete number of gold atoms, forming a crystalline gold core...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208866/acute-kidney-injury-in-patients-with-acute-viral-hepatitis-a-study-in-a-tertiary-care-hospital
#6
M A Rahman, D K Roy, C R Debnath, A S Roy, M A Muqueet, M S Kabir, S U Ahammed, M G Rabbani, M Asadujjaman, M B Hossain, M A Islam, N C Ray, G C Borman, M S Islam, S K Das, E H Khan, J Ara
This cross sectional observational study was done in the Department of Medicine, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh from May 2013 to April 2014 to find out the proportion of acute kidney injury among patients with acute viral hepatitis and to identify risk factors associated with development of acute kidney injury (AKI). A total of 100 patients with acute viral hepatitis were included purposively as study subjects. Among them 61 were male and 39 were female. They were divided into AKI group (n=6) and non-AKI group (n=94) on the basis of development of AKI...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29201778/liver-disease-in-sri-lanka
#7
REVIEW
Hasitha S Wijewantha
Liver disease in Sri Lanka is mainly due to alcoholic liver disease and nonalcoholic fatty liver disease. In contrast to other South Asian countries, the prevalence of hepatitis B and C is low in Sri Lanka and prevalence of hepatitis A is intermediate. The few reported cases of hepatitis E in Sri Lanka are mainly in people who have traveled to neighboring South Asian countries. Wilson's disease, autoimmune hepatitis, hemochromatosis, drug-induced liver disease, and primary biliary cirrhosis are recognized causes of liver disease in Sri Lanka...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29201777/current-treatment-of-acute-and-chronic-hepatitis-e-virus-infection-role-of-antivirals
#8
REVIEW
Ananta Shrestha, Birendra P Gupta, Thupten K Lama
Hepatitis E virus (HEV) infection results in nearly 20 million new infections, resulting in 70,000 deaths globally each year. Previously thought as a disease limited to developing nations with poor sanitation and hygiene, it is increasingly recognized that even the most developed nations are not spared. A clear dichotomy in epidemiology of HEV is noted between developing and industrialized nations. The HEV genotypes 1 and 2 are common in Asia and Africa and are transmitted mainly by contaminated drinking water...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29194722/the-rna-genome-of-hepatitis-e-virus-robustly-triggers-antiviral-interferon-response
#9
Wenshi Wang, Yijin Wang, Changbo Qu, Shan Wang, Jianhua Zhou, Wanlu Cao, Lei Xu, Buyun Ma, Mohamad S Hakim, Yuebang Yin, Tiancheng Li, Maikel P Peppelenbosch, Jingmin Zhao, Qiuwei Pan
The outcomes of hepatitis E virus (HEV) infection are diverse, ranging from asymptomatic carrier, self-limiting acute infection, fulminant hepatitis to persistent infection. This is closely associated with the immunological status of the host. This study aims to understand the innate cellular immunity as the first-line defense mechanisms in response to HEV infection. Phosphorylation of STAT1, a hallmark of the activation of antiviral interferon (IFN) response, was observed in the liver tissues of majority of HEV infected patients, but not in the liver of uninfected individuals...
December 1, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29194671/chronic-hepatitis-e-in-patients-with-indolent-lymphoma-after-treatment-with-rituximab-and-bendamustine
#10
Khaled Alnuaimi, Julie Lavolé, Caroline Lascoux-Combes, Anne-Marie Roque Afonso, Philippe Sogni, Stanislas Pol, Vincent Mallet
No abstract text is available yet for this article.
December 1, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29192575/-current-dilemmas-on-the-transmission-of-hepatitis-e-virus
#11
E de Weerd-de Jong, A M Peters, J C Rahamat-Langendoen, N M A Blijlevens
Immunocompromised patients are especially at risk for developing chronic hepatitis E virus (HEV) infection, which may result in progressive liver disease and cirrhosis. In addition, treatment of chronic HEV infection in these patients often includes dose reduction of immunosuppressive therapy and this may lead to severe flare-ups of the underlying condition or even rejection of transplant material. Therefore prevention of HEV transmission is being more and more recognised as an essential step to stop increasing HEV seroprevalence...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29187150/identification-of-pathogens-for-differential-diagnosis-of-fever-with-jaundice-in-the-central-african-republic-a-retrospective-assessment-2008-2010
#12
Christelle Luce Bobossi Gadia, Alexandre Manirakiza, Gaspard Tekpa, Xavier Konamna, Ulrich Vickos, Emmanuel Nakoune
BACKGROUND: Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbovirus), parasites (malaria) and bacteria (leptospirosis). In the Central African Republic (CAR), only yellow fever is included on the list of diseases for surveillance...
November 29, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29186448/hepatitis-e-virus-seroprevalence-and-correlates-of-anti-hev-igg-antibodies-in-the-rakai-district-uganda
#13
Denali Boon, Andrew D Redd, Oliver Layendecker, Ronald Engle, Hanh Nguyen, Ponsiano Ocama, Iga Boaz, Anthony Ndyanabo, Valerian Kiggundu, Steven J Reynolds, Ronald H Gray, Maria Wawer, Robert H Purcell, Gregory D Kirk, Thomas C Quinn, Lara Stabinski
A cross-sectional study was conducted of 500 HIV-infected adults frequency matched on age, sex, and community to 500 HIV-uninfected individuals in the Rakai District, Uganda to evaluate seroprevalence of anti-hepatitis E virus (HEV) IgG antibodies. HEV seroprevalence was 47%, and one individual was actively infected with a genotype 3 virus. Using modified Poisson regression, male sex (PRR=1.247 [95%CI: 1.071-1.450]) and chronic HBV infection (PRR=1.377 [95%CI: 1.090-1.738]) were associated with HEV seroprevalence...
November 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29176816/a-large-outbreak-of-hepatitis-e-virus-genotype-1-infection-in-an-urban-setting-in-chad-likely-linked-to-household-level-transmission-factors-2016-2017
#14
Alexander Spina, Annick Lenglet, David Beversluis, Marja de Jong, Larissa Vernier, Craig Spencer, Fred Andayi, Charity Kamau, Simone Vollmer, Boris Hogema, Andrea Irwin, Roger Ngueremi Yary, Açyl Mahamat Ali, Ali Moussa, Prince Alfani, Sibylle Sang
BACKGROUND: In September 2016, three acutely jaundiced (AJS) pregnant women were admitted to Am Timan Hospital, eastern Chad. We described the outbreak and conducted a case test-negative study to identify risk factors for this genotype of HEV in an acute outbreak setting. METHODS: Active case finding using a community based surveillance network identified suspected AJS cases. Pregnant or visibly ill AJS cases presenting at hospital were tested with Assure® IgM HEV rapid diagnostic tests (RDTs) and some with Polymerase Chain Reaction (PCR) in Amsterdam; confirmed cases were RDT-positive and controls were RDT-negative...
2017: PloS One
https://www.readbyqxmd.com/read/29174543/new-models-to-study-hepatitis-e-virus-replication-and-particular-characteristics-of-infection-the-needle-hides-in-the-hay-stack
#15
EDITORIAL
Yannick Debing, Michael A Schmid, Johan Neyts
No abstract text is available yet for this article.
November 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29173594/serological-evidence-of-hepatitis-e-virus-infection-in-zoo-animals-and-identification-of-a-rodent-borne-strain-in-a-syrian-brown-bear
#16
Carina Spahr, René Ryll, Tobias Knauf-Witzens, Thomas W Vahlenkamp, Rainer G Ulrich, Reimar Johne
Hepatitis E virus (HEV) is the causative agent of hepatitis E, an emerging infectious disease of humans. HEV infections have also been described in various animal species. Whereas domestic pigs and wild boars are well-known animal reservoirs for HEV, the knowledge on natural HEV infection in zoo animals is scarce so far. Here, we analysed 244 sera from 66 mammal species derived from three zoos in Germany using a commercial double antigen sandwich ELISA. HEV-specific antibodies were detected in 16 animal species, with the highest detection rates in suids (33...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29173588/a-comprehensive-study-of-hepatitis-e-virus-infection-in-pigs-entering-a-slaughterhouse-in-slovenia
#17
Petra Raspor Lainšček, Ivan Toplak, Andrej Kirbiš
Hepatitis E is a zoonotic viral disease of pigs with increasing public health concern in industrialized countries. Presented broad study of hepatitis E virus (HEV) presence in pigs in Slovenia is the first attempt to overview the HEV situation in pigs entering a slaughterhouse and, further, to analyse the possibility of HEV entering into the food supply chain. 2433 samples from 811 clinically healthy pigs were collected at four slaughterhouses in Slovenia. Sampling covered three different age groups of pigs and three different types of samples (faeces, bile and liver) important for tracing HEV in a pig population...
December 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29168441/detection-of-hev-specific-antibodies-in-four-non-human-primate-species-including-great-apes-from-different-zoos-in-germany
#18
C Spahr, T Knauf-Witzens, L Dähnert, M Enders, M Müller, R Johne, R G Ulrich
The hepatitis E virus (HEV) has been described in humans and various animal species in different regions of the world. However, the knowledge on natural HEV infection in non-human primates and the corresponding risk of zoonotic transmission is scarce. To determine whether primates in captivity are affected by HEV infection, we investigated 259 individual sera of clinically healthy non-human primates of 14 species from nine German zoos. Using a commercial double-antigen-sandwich ELISA and a commercial IgG ELISA, 10 animals (3·9%) reacted positive in at least one assay...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29167341/novel-synthesis-and-phenotypic-analysis-of-mutant-clouds-for-hepatitis-e-virus-genotype-1
#19
Shubhra Agarwal, Prasith Baccam, Rakesh Aggarwal, Naga Suresh Veerapu
Many RNA viruses exist as an ensemble of genetically-diverse, replicating populations, known as mutant cloud. The genetic diversity (cloud size) and composition of this mutant cloud may influence several important phenotypic features of the virus, including its replication capacity. We applied a straightforward, bacterium-free approach using error-prone PCR coupled with reverse genetics to generate infectious mutant RNA clouds of varying genetic diversity from a genotype 1 strain of hepatitis E virus (HEV)...
November 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29162935/hepatitis-e-virus-advances-and-challenges
#20
REVIEW
Ila Nimgaonkar, Qiang Ding, Robert E Schwartz, Alexander Ploss
At least 20 million hepatitis E virus (HEV) infections occur annually, with >3 million symptomatic cases and ∼60,000 fatalities. Hepatitis E is generally self-limiting, with a case fatality rate of 0.5-3% in young adults. However, it can cause up to 30% mortality in pregnant women in the third trimester and can become chronic in immunocompromised individuals, such as those receiving organ transplants or chemotherapy and individuals with HIV infection. HEV is transmitted primarily via the faecal-oral route and was previously thought to be a public health concern only in developing countries...
November 22, 2017: Nature Reviews. Gastroenterology & Hepatology
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