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Colorectal neoplasm and stage 4

Takuji Kawamura, Koji Uno, Kiyohito Tanaka, Yuki Ueda, Naokuni Sakiyama, Kensei Nishida, Kazuhito Rokutan, Kenjiro Yasuda
This retrospective study aimed to clarify the clinical characteristics of advanced colorectal neoplasms after colonoscopy, likely to have been missed on the previous colonoscopy. We reviewed a total of 5,768 consecutive colonoscopies performed from April 2010 to September 2013 in 4,841 patients, and analyzed advanced colorectal neoplasms after colonoscopy, particularly focusing on their morphological characteristics and locations, as compared with primary lesions, defined as lesions detected in their first colonoscopy or in a subsequent colonoscopy >5 years after the previous one...
2016: Journal of Medical Investigation: JMI
Tatsuo Yachida, Takeshi Nakajima, Satoru Nonaka, Keiko Nakamura, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Yoshihiro Moriya, Tsutomu Masaki, Yutaka Saito
BACKGROUND: After colorectal cancer and desmoid tumors, duodenal adenocarcinoma is the next leading cause of death in familial adenomatous polyposis (FAP) patients, but it has not been thoroughly investigated. PATIENTS AND METHODS: To investigate the clinical course of duodenal neoplasia, including adenoma and cancer, we investigated 77 Japanese FAP patients treated at the National Cancer Center Hospital, Tokyo, Japan. We evaluated the clinicopathologic features, Spigelman severity score, and management of duodenal neoplasms...
June 15, 2016: Journal of Clinical Gastroenterology
Name Name, Teeranut Boonpipattanapong, Anuwat Palanusont, Wanwisa Maneechay, Surasak Sangkhathat
BACKGROUND: There is an established link between obesity related metabolic derangement and colorectal cancer development. Recently, we developed a metabolic-colorectal cancer risk score. In this follow-up study, we studied its association with colorectal neoplasm by measuring two major metabolic syndrome biomarkers, leptin and adiponectin. OBJECTIVES: To evaluate the serum levels of leptin and adiponectin in patients with colorectal polyps and colorectal cancer and to determine any correlation with metabolic risk score...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
A Romaszko, E Świetlik, A Doboszyńska, P Szpruch, J Luks
Over the past 30 years there has been an increase in the survival of cancer patients resulting from the advances in cancer management and improved detection of cancer in its early stages. The aim of the study was to analyze the frequency of multiple malignancies in a sample of hospitalized patients in Poland. We analyzed retrospectively the records of 1112 cancer patients hospitalized in the period of January 2013 - August 2014. The criterion for inclusion into the group of multiple malignancy patients was the presence of at least two different malignancies...
2016: Advances in Experimental Medicine and Biology
A Cistaro, M Cucinotta, L Cassalia, A Priola, S Priola, M Pappalardo, P Coppolino, M De Simone, N Quartuccio
AIM: Peritoneal carcinomatosis is a common evolution of neoplasms and the terminal stage of disease. A new therapeutic technique, based on the total surgical removal of peritoneal lesions (peritonectomy procedure - PP) combined with the intraperitoneal chemohyperthermia (IPCH), has been developed. Proper patient selection is mandatory for optimizing the results of treatment. The aim of this study was to investigate the role of [(18)F]fluoro-2-deoxy-d-glucose Positron Emission Tomography/Computed Tomography ((18)F-FDG PET/CT) in patients with peritoneal carcinosis selected to undergo PP and IPCH...
July 2016: Revista Española de Medicina Nuclear e Imagen Molecular
Ignazio Tarantino, Felix J Hüttner, Rene Warschkow, Bruno M Schmied, Markus K Diener, Alexis Ulrich
BACKGROUND: The prognostic relevance of mucinous histology in colorectal cancer remains unclear, especially for rectal neoplasms. The objective of this study was to evaluate if mucinous subtype has a relevant impact on overall survival (OS) and cancer-specific survival (CSS) of patients with adenocarcinomas of the rectum. METHODS: On the basis of the data set of the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute of the United States, patients with rectal cancer between 2004 and 2011 were identified...
May 2016: Annals of Surgical Oncology
Arne Warth, Sandrina Körner, Roland Penzel, Thomas Muley, Hendrik Dienemann, Peter Schirmacher, Magnus von Knebel-Doeberitz, Wilko Weichert, Matthias Kloor
A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency, leading to accumulation of numerous mutations at repetitive DNA sequence stretches (microsatellites), known as high-level microsatellite instability (MSI-H). In colorectal cancer, MSI-H tumors show a clinical behavior different from microsatellite-stable (MSS) tumors. Data about the prevalence of MSI among non-small cell lung cancer (NSCLC) are conflicting, and clinical relevance of MSI is largely unknown. We analyzed a series of 480 pulmonary adenocarcinomas (ADC) for MSI using a sensitive mononucleotide marker panel (BAT25, BAT26, and CAT25)...
March 2016: Virchows Archiv: An International Journal of Pathology
Roseane Mendes Silva, Vanessa Maria de Lima Pazine Campanholo, Ana Paula Ribeiro Paiotti, Ricardo Artigiani Neto, Celina Tizuko Fujiyama Oshima, Daniel Araki Ribeiro, Nora Manoukian Forones
Colorectal cancer is the third most common cancer worldwide in both sexes, with similar geographic patterns between genders. This neoplasm has good prognosis if the disease is diagnosed at early stages. The aim of this study was to evaluate the effect of red grape juice on the expression of COX-2 and Ki-67 expression following colon carcinogenesis induced by azoxymethane (AOM). Thirty-five rats were randomly distributed into seven groups (n=5 per group): G1: SHAM or negative control received only saline; G2 (positive control): animals received 15 mg/kg AOM; G3: animals received 1% red grape juice 2 weeks before the administration of AOM; G4: animals received 2% red grape juice 2 weeks before the administration of AOM; G5: animals received 1% red grape juice 4 weeks after the last administration of AOM; G6: animals received 2% red grape juice 4 weeks after the last administration of AOM; G7: animals received only 2% red grape juice...
November 2015: Environmental Toxicology and Pharmacology
Francesco Iachetta, Federica Domati, Luca Reggiani-Bonetti, Valeria Barresi, Giulia Magnani, Luigi Marcheselli, Claudia Cirilli, Monica Pedroni
Although surgery alone represents a curative approach for patients with pT3N0M0 colon cancer, about 15-20% of these patients develop a relapse of disease. Microsatellite instability (MSI) is one of the most important molecular markers in colorectal cancer. The aim of this study was to investigate the prognostic relevance of MSI in all pT3N0M0 tumors recorded in the Cancer Registry of the Province of Modena--(Northern Italy) within the 2002-2006 period in patients who showed a relapse of disease during the 5-year period of follow-up (59 cases)...
February 2016: Internal and Emergency Medicine
Zbigniew Lorenc, Mieszko Norbert Opiłka, Celina Kruszniewska-Rajs, Antoni Rajs, Dariusz Waniczek, Małgorzata Starzewska, Justyna Lorenc, Urszula Mazurek
BACKGROUND: Colorectal Cancer (CRC) is one of the most frequently diagnosed neoplasms and also one of the main death causes. Cell adhesion molecules are taking part in specific junctions, contributing to tissue integrality. Lower expression of the cadherins may be correlated with poorer differentiation of the CRC, and its more aggressive phenotype. The aim of the study is to designate the cadherin genes potentially useful for the diagnostics, prognostics, and the treatment of CRC. MATERIAL AND METHODS: Specimens were collected from 28 persons (14 female and 14 male), who were operated for CRC...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Guido Kroemer, Lorenzo Galluzzi, Laurence Zitvogel, Wolf Hervé Fridman
The first study demonstrating that human colorectal carcinoma (CRC) is under robust immunosurveillance was published a decade ago. Today, it is clear that CRC patients with Stage III lesions abundantly infiltrated by effector memory T cells have a better prognosis than subjects with Stage I neoplasms exhibiting no or poor immune infiltration. Thus, immunological parameters have a superior prognostic value for CRC patients than TNM staging or the Dukes classification. In spite of the fact that CRC is the first neoplasia found to be under immunological control, most attempts made so far to cure this malignancy with immunotherapy have failed...
July 2015: Oncoimmunology
Ayan Mao, Pei Dong, Xiaoling Yan, Guangyu Hu, Qingkun Chen, Wuqi Qiu
OBJECTIVE: To conduct with a cost analysis of the colorectal neoplasm screening program in Beijing, and provide data evidence for decision making. METHODS: Based on stratified cluster sampling method, we carried out a 2-stage colorectal neoplasm screening program within 6 districts, Dongcheng, Xicheng, Chaoyang, Haidian, Fengtai and Shijingshan, of Beijing city between October, 2012 to May. 2013. The first stage of the program was to conducting a cancer risk level evaluation for community residents who were forty years older and the second stage's task was to providing clinical exam for those high risk people who were selected from the first stage...
May 2015: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Li-Chun Chang, Han-Mo Chiu, Chia-Tung Shun, Jin-Tung Liang, Jaw-Town Lin, Chien-Chuan Chen, Yi-Chia Lee, Ming-Shiang Wu
BACKGROUND: Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in adenoma stage and a comprehensive survey of oncogenic mutations in EGFR signaling pathway according to different morphologic subtypes has not been performed. METHODS: A total of 94 neoplasms, including 34 polypoid adenoma, 16 lateral spreading tumors-granular (LST-G), 20 non-granular LST (LST-NG), and 24 depressed tumors, were subjected for mutational analysis of KRAS (exon 2), BRAF (exon 11 and 15), PIK3CA (exon 9 and 20), AKT (exon 4), EGFR (exon 18-24) and HER2 (exon18-24)...
2014: BMC Gastroenterology
B Seifert, O Májek, M Zavoral, N Král, S Suchánek, O Ngo, L Dušek
INTRODUCTION: The nationwide Colorectal Cancer Screening Programme was introduced in the Czech Republic in 2000. The aim of this article is to describe the employment of faecal occult blood tests (FOBTs) by the Czech population within the screening programme, and to provide information on the latest results of the programme. MATERIAL AND METHODS: Data on the development of the colorectal cancer (CRC) burden in the Czech population is obtained from the Czech National Cancer Registry, a database required by the Czech law that has been collecting comprehensive data on cancer patients since 1977...
2014: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Małgorzata Ławniczak, Alicja Gawin, Halina Jaroszewicz-Heigelmann, Wiesława Rogoza-Mateja, Joanna Raszeja-Wyszomirska, Andrzej Białek, Katarzyna Karpińska-Kaczmarczyk, Teresa Starzyńska
AIM: To determine the prevalence and characteristics of additional primary malignancies in gastric cancer (GC) patients. METHODS: GC patients (862 total; 570 men, 292 women; mean age 59.8 ± 12.8 years) diagnosed at the Department of Gastroenterology at Pomeranian Medical University over a period of 23 years were included in this retrospective analysis of a prospectively maintained database. Mean follow-up time was 31.3 ± 38.6 mo (range 1-241 mo). The following clinicopathological features of patients with synchronous tumors were compared to those with metachronous tumors: age, sex, symptom duration, family history of cancer, tumor site, stage (early vs advanced), histology, and blood group...
June 21, 2014: World Journal of Gastroenterology: WJG
Xavier Serra-Aracil, Aleidis Caro-Tarrago, Laura Mora-López, Alex Casalots, Pere Rebasa, Salvador Navarro-Soto
BACKGROUND: Colorectal adenomatous polyps are considered premalignant lesions, although a high percentage are already malignant at the time of their removal. Full-thickness excision in patients with adenoma detected in preoperative biopsy enables much more accurate pathology examination and has shown that local surgery is appropriate for T1 adenocarcinoma. OBJECTIVE: To determine whether full-thickness excision during transanal endoscopic surgery is the treatment of choice for rectal adenoma, and to identify possible predictors of invasive adenocarcinoma associated with this type of lesion...
July 2014: Diseases of the Colon and Rectum
Remzi Beştaş, M Ali Kaplan, Abdurrahman Işikdoğan
BACKGROUND/AIMS: In the present study, we analyzed serum vascular endothelial growth factor (VEGF) levels and its correlation with the other clinicopathological characteristics of patients with colorectal carcinoma (CRC). METHODOLOGY: Seventy-one patients (F/M, 29/42; Mean age +/- SD, 53.3 +/- 13.1 years) were included. The results of serum VEGF were analysed with respect to stage, gender, age, CEA, metastases and topographical tumour localization. RESULTS: Patients with stage 3-4 disease had significantly higher values of VEGF (253...
March 2014: Hepato-gastroenterology
Sander B Schouten, Anthonius F J De Bruin, Martijn P Gosselink, Alex L Nigg, Mat van Iterson, Katherina Biermann, Mike Kliffen, Erwin van der Harst
BACKGROUND/AIMS: Anastomotic leakage after low anterior resection may be the result of poor vascular supply from the proximal anastomotic loop. The purpose of this study was to investigate the correlation between colonic microvessel density and anastomotic breakdown. METHODOLOGY: Between 2006 and 2009, a consecutive series of 81 patients underwent double-stapled low anterior resection followed by a colorectal anastomosis. Symptomatic anastomotic leakage occurred in 14 patients (17%)...
January 2014: Hepato-gastroenterology
Turgay Simsek, Nuh Zafer Canturk, Zeynep Canturk, Oktay Ahmet Yirmibesoglu, Zülfü Bayhan, Sarpkaya Oz
BACKGROUND/AIMS: To evaluate association of serum lipids and fasting plasma glucose levels with colorectal cancer. METHODOLOGY: This prospective case control study was conducted with 347 patients with colorectal carcinoma and 310 age and gender matched healthy controls who were examined for annual check-up. Total cholesterol, serum lipids and fasting glucose levels were measured in both groups. Body weight and body mass indices were also evaluated. RESULTS: The mean serum cholesterol level was 167...
January 2014: Hepato-gastroenterology
M-C Etienne-Grimaldi, A Mahamat, M Chazal, P Laurent-Puig, S Olschwang, M-P Gaub, J-L Formento, P Formento, A Sudaka, V Boige, A Abderrahim-Ferkoune, D Benchimol, T André, S Houry, J-L Faucheron, C Letoublon, F-N Gilly, J-R Delpero, P Lasser, B Pradere, D Pezet, F Penault-Llorca, G Milano
BACKGROUND: To test the prognostic value of tumour protein and genetic markers in colorectal cancer (CRC) and examine whether deficient mismatch repair (dMMR) tumours had a distinct profile relative to proficient mismatch repair (pMMR) tumours. METHODS: This prospective multicentric study involved 251 stage I-III CRC patients. Analysed biomarkers were EGFR (binding assay), VEGFA, thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) expressions, MMR status, mutations of KRAS (codons 12-13), BRAF (V600E), PIK3CA (exons 9 and 20), APC (exon 15) and P53 (exons 4-9), CpG island methylation phenotype status, ploidy, S-phase, LOH...
May 27, 2014: British Journal of Cancer
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