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Platelet rich plasma skin

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https://www.readbyqxmd.com/read/29126293/commentary-on-effect-of-use-of-platelet-rich-plasma-prp-in-skin-with-intrinsic-aging-process
#1
Matthew D McLeod, William G Austen
No abstract text is available yet for this article.
November 4, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29076239/use-of-epidermal-skin-grafts-in-chronic-wounds-a-case-series
#2
Peter Am Everts, Marco Warbout, Diana de Veth, Merel Cirkel, Nicole E Spruijt, Jaap Buth
In stalled, chronic wounds, more aggressive and proactive wound closure efforts are needed. We describe adjunctive use of epidermal grafting in patients with chronic wounds. Wound bed preparation consisted of surgical necrotectomy or sharp debridement, hyperbaric oxygen therapy, negative pressure wound therapy, compression therapy, platelet-rich plasma therapy and/or heparan sulphate agents. Epidermal grafts were harvested from the patient's thigh and applied to the wound. Wound and donor site healing was monitored...
October 27, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29058626/combined-platelet-rich-plasma-and-lipofilling-treatment-provides-great-improvement-in-facial-skin-induced-lesion-regeneration-for-scleroderma-patients
#3
Francesco Virzì, Paola Bianca, Alessandro Giammona, Tiziana Apuzzo, Simone Di Franco, Laura Rosa Mangiapane, Maria Luisa Colorito, Dario Catalano, Emanuela Scavo, Annalisa Nicotra, Antonina Benfante, Giuseppe Pistone, Valentina Caputo, Francesco Dieli, Roberto Pirrello, Giorgio Stassi
BACKGROUND: The use of stem cells, including mesenchymal stem cells (MSCs), for regenerative medicine is gaining interest for the clinical benefits so far obtained in patients. This study investigates the use of adipose autologous tissue in combination with platelet-rich plasma (PRP) to improve the clinical outcome of patients affected by systemic sclerosis (SSc). METHODS: Adipose-derived mesenchymal stem cells (AD-MSCs) and PRPs were purified from healthy donors and SSc patients...
October 23, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29049258/autologous-platelet-rich-plasma-thrombin-gel-combined-with-split-thickness-skin-graft-to-manage-postinfectious-skin-defects-a-randomized-controlled-study
#4
Barbara Hersant, Mounia SidAhmed-Mezi, Romain Bosc, Jean-Paul Meningaud
BACKGROUND: Managing cutaneous substance loss after debridement is challenging, especially if it is secondary to necrotizing soft tissue infection, such as necrotizing fasciitis and Fournier gangrene. After skin graft reconstruction, the healing process is longer and may be difficult, depending on the wound site, skin defect size, and patient comorbidities. OBJECTIVE: The aim of this study was to investigate whether autologous platelet-rich plasma (A-PRP) could accelerate and improve wound healing after cutaneous reconstruction for tissue loss secondary to soft tissue infection...
November 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29040421/effect-of-use-of-platelet-rich-plasma-prp-in-skin-with-intrinsic-aging-process
#5
Luiz Charles-de-Sá, Natale Ferreira Gontijo-de-Amorim, Christina Maeda Takiya, Radovan Borojevic, Donatella Benati, Paolo Bernardi, Andrea Sbarbati, Gino Rigotti
Background: In previous papers, we demonstrated that the treatment of human photoaged skin with stromal-vascular fraction-enriched fat or expanded adipose-derived stem cells showed a decrease of elastosis and the appearance of new oxytalan elastic fibers in dermis and an increase in the vascular network. The utilization of fat plus platelet-rich plasma (PRP) led to an increase in the vascular permeability and reactivity of the nervous component. Objectives: The purpose of this study was to analyze the histologic and ultrastructural changes of human skin after the injection of only PRP in the retroauricular area that was not exposed to sun and did not present the photoaging process, in comparison with our previous results...
September 7, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29026811/the-use-of-platelet-rich-plasma-for-storage-of-surplus-harvested-skin-grafts
#6
Ilknur Keskin, Nilufer Ayturk, Mustafa Sutcu, Mustafa Keskin, Tangul Mudok
BACKGROUND: There is a need for improved methods and storage media to sustain the tissue viability of autologous skin grafts. OBJECTIVE: To compare histological changes in human skin grafts stored in platelet-rich plasma (PRP) with those of grafts stored in saline. METHODS: Eight circular, 3-mm full-thickness skin graft samples were harvested from the abdominal skin of each of 5 patients scheduled to undergo an abdominoplasty procedure. Four of these graft samples were stored in saline, and the other 4 were stored in saline mixed with PRP prepared from the patient's own venous blood...
February 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29020977/platelet-rich-plasma-stimulates-angiogenesis-in-mice-which-may-promote-hair-growth
#7
Hanxiao Cheng, Jufang Zhang, Jinsheng Li, Ming Jia, Yuyan Wang, Haiyan Shen
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets in plasma. In this paper, we aimed to investigate the effect of PRP on hair growth. METHODS: Platelet-rich plasma and platelet-poor plasma were prepared by sterile centrifugation and injected into shaved dorsal skin of mice (n = 10). Saline injection was used in the control group. The length of randomly plucked hairs was measured at 8, 13, 18 days after PRP injection. Histological examination was preformed to observe the histologic changes of skins...
October 11, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29019860/the-addition-of-prp-to-facial-lipofilling-a-double-blind-placebo-controlled-randomized-trial
#8
J C N Willemsen, J Van Dongen, M Spiekman, K M Vermeulen, M C Harmsen, B van der Lei, H P J D Stevens
BACKGROUND: Lipofilling is a treatment modality to restore tissue volume, but may also rejuvenate the aging skin. Platelet-rich plasma has been reported to augment the efficacy of lipofilling, both on graft take and rejuvenation by altering the ADSC. Authors hypothesized that PRP addition would increase the rejuvenating effect while shortening recovery time. METHODS: The study conducted was a single-centre, double blinded, placebo-controlled randomized trial (2012-2015)...
October 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28948378/a-comparative-study-between-platelet-rich-plasma-and-platelet-poor-plasma-effects-on-angiogenesis
#9
Minoo Shahidi, Mousa Vatanmakanian, Masoumeh Kourosh Arami, Fatemeh Sadeghi Shirazi, Najibeh Esmaeili, Samaneh Hydarporian, Soudeh Jafari
Platelet-rich plasma (PRP) has been established as an autologous source for therapeutic angiogenesis. The purpose of this study was to evaluate PRP angiogenic effects compared to platelet-poor plasma (PPP) in vitro and in vivo. The effects of PRP on vascular endothelial growth factor receptor-2 (VEGFR2) and CD34 expression were evaluated using real-time PCR, flow cytometry, western blot, immunocytochemistry and pathological study, as were carried out in both human umbilical endothelial cell culture and rat skin...
September 25, 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/28887865/plasma-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#10
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28886194/a-new-rabbit-model-of-impaired-wound-healing-in-an-x-ray-irradiated-field
#11
Kazutoshi Fujita, Soh Nishimoto, Toshihiro Fujiwara, Yohei Sotsuka, Maki Tonooka, Kenichiro Kawai, Masao Kakibuchi
Radiation is an important therapy for cancer with many benefits; however, its side effects, such as impaired wound healing, are a major problem. While many attempts have been made to overcome this particular disadvantage, there are few effective treatments for impaired wound healing in an X-ray-irradiated field. One reason for this deficiency is the lack of experimental models, especially animal models. We have previously reported a mouse model of impaired wound healing in which the irradiation area was restricted to the hindlimbs...
2017: PloS One
https://www.readbyqxmd.com/read/28863268/2-years-outcome-of-thread-lifting-with-absorbable-barbed-pdo-threads-innovative-score-for-objective-and-subjective-assessment
#12
Yasser Helmy Ali
BACKGROUND: Thread lifting rejuvenation procedures are re-evolved again, after developing of absorbable threads, with very popular spread among plastic surgeons and dermatologists but with little articles have been written in literature about absorbable threads. Objective to evaluate two years' outcome of absorbable barbed thread lifting used for facial rejuvenation. METHODS: Prospective comparative study both objectively and subjectively and follow up assessment for 24 months...
September 1, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28807118/efficacy-of-autologous-platelet-rich-plasma-combined-with-hyaluronic-acid-on-skin-facial-rejuvenation-a-prospective-study
#13
LETTER
Barbara Hersant, Mounia SidAhmed-Mezi, Jeremy Niddam, Simone La Padula, Warren Noel, Khaled Ezzedine, Anne Marie Rodriguez, Jean Paul Meningaud
No abstract text is available yet for this article.
September 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28782384/skin-microneedling-plus-platelet-rich-plasma-versus-skin-microneedling-alone-in-the-treatment-of-atrophic-post-acne-scars-a-split-face-comparative-study
#14
Mohamed Kotb Ibrahim, Shady Mahmoud Ibrahim, Amany Mohamed Salem
INTRODUCTION: Acne scarring is a permanent disfiguring sequel, which can take varied morphological forms. Many therapeutic measures have been performed to improve acne scarring such as microneedling. Our objective is to evaluate the efficacy and safety of microneedling alone versus microneedling combined with platelet rich plasma in the treatment of post acne. METHODS: The study included 35 patients with mild to severe post acne atrophic scar. All the patients received four sequential treatments of skin microneedling alone on the right side of the face and skin microneedling followed by topical application of platelet rich plasma (PRP) on the left side of the face with an interval of 3 weeks...
September 26, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28713711/the-role-of-human-adult-peripheral-and-umbilical-cord-blood-platelet-rich-plasma-on-proliferation-and-migration-of-human-skin-fibroblasts
#15
Seyedeh-Sara Hashemi, Mahdokht Mahmoodi, Ali Reza Rafati, Farzad Manafi, Davood Mehrabani
BACKGROUND: Wound healing is a complex and dynamic process following damage in tissue structures. Due to extensive skin damage caused by burn injuries, this study determined the role of human adult peripheral and umbilical cord blood platelet-rich plasma on proliferation and migration in human skin fibroblasts. METHODS: Platelet-rich plasma (5, 10, 15, 20 and 50% PRP) from human umbilical cord blood and adult peripheral blood were provided and added to fibroblasts cultured from a human skin sample...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28694685/differential-effect-of-platelet-rich-plasma-fractions-on-%C3%AE-1-integrin-signaling-collagen-biosynthesis-and-prolidase-activity-in-human-skin-fibroblasts
#16
Tomasz Guszczyn, Arkadiusz Surażyński, Ilona Zaręba, Edyta Rysiak, Janusz Popko, Jerzy Pałka
The study was conducted to evaluate the effects of platelet-rich plasma (PRP), supernatant of PRP (SPRP) obtained by centrifugation, and supernatant of activated PRP (SActi-PRP) obtained by Ca(2+) solution-treated PRP on collagen biosynthesis, prolidase activity, and β1-integrin signaling in cultured human skin fibroblasts. Incubation of fibroblasts with 5% PRP for 24 h contributed to ~5-fold increase in collagen biosynthesis compared to the control. In the cells treated with 5% of SPRP or SActi-PRP, collagen biosynthesis showed a 3-fold increase of the control...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28689433/experimental-and-early-investigational-drugs-for-androgenetic-alopecia
#17
REVIEW
Hongwei Guo, Wendi Victor Gao, Hiromi Endo, Kevin John McElwee
Treatments for androgenetic alopecia constitute a multi-billion-dollar industry, however, currently available therapeutic options have variable efficacy. Consequently, in recent years small biotechnology companies and academic research laboratories have begun to investigate new or improved treatment methods. Research and development approaches include improved formulations and modes of application for current drugs, new drug development, development of cell-based treatments, and medical devices for modulation of hair growth...
August 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28625328/platelet-rich-plasma-for-the-treatment-of-photodamage-of-the-skin-of-the-hands
#18
J O Cabrera-Ramírez, A G Puebla-Mora, A González-Ojeda, D García-Martínez, J A Cortés-Lares, A R Márquez-Valdés, G I Contreras-Hernández, J Bracamontes-Blanco, J A Saucedo Ortiz, C Fuentes-Orozco
BACKGROUND: Platelet-rich plasma (PRP) provides growth factors that stimulate fibroblast activation and induce the synthesis of collagen and other components of the extracellular matrix. The objective of this study was to evaluate the effect of PRP in the treatment of photodamage of the skin of the hands. MATERIAL AND METHODS: Experimental study enrolling persons with photoaged skin on the dorsum of the hands (Glogau photoaging scale, type III, or Fitzpatrick wrinkle classification, type II) were included between August 2012 and January 2013...
October 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28615133/platelet-rich-plasma-with-keratinocytes-and-fibroblasts-enhance-healing-of-full-thickness-wounds
#19
Jia Xian Law, Shiplu Roy Chowdhury, Aminuddin Bin Saim, Ruszymah Bt Hj Idrus
Advances in tissue engineering led to the development of various tissue-engineered skin substitutes (TESS) for the treatment of skin injuries. The majority of the autologous TESS required lengthy and costly cell expansion process to fabricate. In this study, we determine the possibility of using a low density of human skin cells suspended in platelet-rich plasma (PRP)-enriched medium to promote the healing of full-thickness skin wounds. To achieve this, full-thickness wounds of size 1.767 cm(2) were created at the dorsum part of nude mice and treated with keratinocytes (2 × 10(4) cells/cm(2)) and fibroblasts (3 × 10(4) cells/cm(2)) suspended in 10% PRP-enriched medium...
June 7, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28538802/the-effect-of-intradermal-administration-of-inactive-platelet-rich-plasma-on-flap-viability-in-rats
#20
Erkan Orhan, Ahmet Çağrı Uysal, Engin Başer, Dürdane Keskin, Çiğdem Demiroğlu-Yakut
Purpose: To evaluate the effect of inactive form of platelet rich plasma (PRP) on the flap viability. Methods: Thirty six rats were used. Rats were divided into six groups then 9x3 cm random pattern skin flaps were elevated from dorsum of all rats. For precluding vascularization from the base, a silicone layer was placed under the flap in groups 2(only flap+silicone), 4(saline+silicone) and 6(PRP+silicone). In groups 1(only flap), 2(only flap+silicone) nothing was done except flap surgery...
April 2017: Acta Cirúrgica Brasileira
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