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Platelet rich plasma skin

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https://www.readbyqxmd.com/read/28423680/a-bioartificial-dermal-regeneration-template-promotes-skin-cell-proliferation-in-vitro-and-enhances-large-skin-wound-healing-in-vivo
#1
Peng Chang, Bingyu Guo, Qiang Hui, Xiaoyan Liu, Kai Tao
A novel bioartificial dermal regeneration template has been developed using platelet-rich plasma and acellular animal skin collagen sponge for the treatment of larger area and full thickness skin wounds. This platelet-rich plasma-collagen sponge keeps native skin structure and contains huge amounts of growth factors. The effect of this bioartificial dermal regeneration template was tested in vitro and in vivo via a mimic poor wound healing process by adding collagenase I into cell culture medium or the wound area...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28382785/autologous-platelet-rich-plasma-versus-readymade-growth-factors-in-skin-rejuvenation-a-split-face-study
#2
Heba I Gawdat, Amira M Tawdy, Rehab A Hegazy, Mohga M Zakaria, Ryham S Allam
BACKGROUND: The escalating urge for a youthful-looking skin instigates continuous innovations with minimally invasive procedures. Readymade growth factors and autologous platelet-rich plasma (PRP) represent such therapeutic interventions. OBJECTIVE: Compare the efficacy and safety of PRP to readymade growth factors in skin rejuvenation. PATIENTS AND METHODS: Twenty adult females with Fitzpatrick skin types III-IV and Glogau photoaging types II and III were enrolled in this study...
April 5, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28375975/autologous-pure-platelet-rich-plasma-dermal-injections-for-facial-skin-rejuvenation-clinical-instrumental-and-flow-cytometry-assessment
#3
Norma Cameli, Maria Mariano, Iole Cordone, Elva Abril, Serena Masi, Maria Laura Foddai
BACKGROUND: Platelet-rich plasma (PRP) is an emerging treatment in dermatology recently proposed for skin rejuvenation. OBJECTIVE: To evaluate the efficacy and safety of autologous pure PRP dermal injections on facial skin rejuvenation, investigating the cellularity of PRP samples. MATERIALS AND METHODS: Twelve patients underwent 3 sessions of PRP injection at 1-month intervals. The clinical and instrumental outcomes were evaluated before (T0) and 1 month (T1) after the end of treatment by means of transepidermal water loss, corneometry, Cutometer, Visioscan, and Visioface...
April 3, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28321425/adult-cells-combined-with-platelet-rich-plasma-for-tendon-healing-cell-source-options
#4
Eva Rubio-Azpeitia, Pello Sánchez, Diego Delgado, Isabel Andia
BACKGROUND: The combination of cells with platelet-rich plasma (PRP) may fulfill tendon deficits and help overcome the limited ability of tendons to heal. PURPOSE: To examine the suitability of 3 human cell types in combination with PRP and the potential impact of the tenocyte-conditioned media (CM) to enhance tendon healing. STUDY DESIGN: Controlled laboratory study. METHODS: Tenocytes, bone marrow-derived mesenchymal stem cells, and skin fibroblasts were cultured in 3-dimensional PRP hydrogels supplemented or not with CM, and cell proliferation and migration were examined...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28314112/can-mesenchymal-stem-cells-pretreated-with-platelet-rich-plasma-modulate-tissue-remodeling-in-a-rat-burn
#5
Hanan Hosni, Laila A Rashed, Soheir Mahfouz, Rania Elsayed Hussein, Marwa Alkaffas, Shaimaa Mostafa, Azza Abusree
AIM: To study the effect of PRP on BM-MSCs proliferation and to investigate their role on healing of experimental burn injury and possible mechanism of action. METHOD: Our work divided into in vitro and in vivo studies. In vitro study included,: MSCs and MSCs treated with PRP. TGF-β level and cell proliferation were assesed. In vivo study, 72 rats divided equally into 6 groups: control, burn, burn with MSCs, burn with PRP, burn with both MSCs and PRP and burn with MSCs pretreated with PRP...
March 17, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28272145/improved-survival-of-full-thickness-skin-graft-with-low-molecular-weight-heparin-protamine-micro-nanoparticles-including-platelet-rich-plasma
#6
Yuki Takabayashi, Masayuki Ishihara, Masahiro Kuwabara, Makoto Takikawa, Shingo Nakamura, Hidemi Hattori, Tomoharu Kiyosawa
BACKGROUND: Activated platelet-rich plasma secrets many growth factors (GFs), and low-molecular weight heparin-protamine micro/nanoparticles (LMWH-P M/NPs) significantly interact with, enhance, and stabilize the secreted GFs. OBJECTIVE: The purpose of this study was to evaluate the effects of LMWH-P M/NPs and GFs (from platelet-rich plasma) on full-thickness skin graft (FTSG). METHODS: A total of 96 inbred male rats were anesthetized and 4-cm full-thickness skin wound were created on dorsal skin of rats...
May 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28246352/evaluation-of-subcutaneous-infiltration-of-autologous-platelet-rich-plasma-on-skin-wound-healing-in-dogs
#7
Haithem A Farghali, Naglaa A AbdElKader, Marwa S Khattab, Huda O Abubakr
Background: Platelet-rich plasma (PRP) is known to be rich in growth factors and cytokines which are crucial to the healing process. Objective: Studying the effect of subcutaneous infiltration of autologous PRP at the wound boundaries on wound epithelization and contraction. Material and Methods: Five adult male mongrel dogs were used. Bilateral acute full-thickness skin wounds (3cm diameter) were created on the thorax symmetrically. Right side wounds were subcutaneously infiltrated with activated PRP at day zero then every week for three consecutive weeks...
February 28, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28216682/use-of-canine-sourced-platelet-rich-plasma-in-a-feline-contaminated-cutaneous-wound
#8
Francesco Gemignani, Anna Perazzi, Ilaria Iacopetti
A 4-year-old neutered female domestic shorthaired cat was treated with canine sourced platelet-rich plasma at the Veterinary Hospital at University of Padua for a large skin defect on the left lateral neck region. The wound healed completely within 20 days and no adverse reaction was observed during the healing process.
February 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28207466/the-subunit-principle-in-scar-face-revision
#9
Ahmed Elshahat, Riham Lashin
Facial scaring is considered one of the most difficult cosmetic problems for any plastic surgeon to solve. The condition is more difficult if the direction of the scar is not parallel to relaxed skin tension lines. Attempts to manage this difficult situation included revisions using geometric designs, Z plasties or W plasties to camouflage the straight line visible scaring. The use of long-lasting resorbable sutures was tried too. Recently, the use of botulinum toxin during revision improved the results. Fractional CO2 lasers, microfat grafts, and platelet-rich plasma were added to the armamentarium...
February 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28203511/a-retrospective-look-at-integrating-a-novel-regenerative-medicine-approach-in-plastic-limb-reconstruction
#10
Edgardo R Rodriguez Collazo, Christopher R Rathbone, Brian R Barnes
Full-thickness wounds that have rendered patients candidates for amputation may require techniques that may include a combinatorial approach above traditional standard of care. The purpose of this retrospective study was to evaluate the effectiveness of an innovative approach whereby several therapies were combined to avoid amputation. Patients with full-thickness wounds who were previously recommended for amputation and were treated with the combinatorial approach of muscle flap reconstruction and concentrated bone marrow aspirate, platelet-rich plasma, INTEGRA Wound matrix, vacuum-assisted closure, and split-thickness skin grafts were assessed retrospectively...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28175965/effects-of-platelet-rich-plasma-on-tissue-expansion-in-rabbits
#11
Wang Jinming, Liu Caiyue, Wu Baojin, Liu Antang, Zhang Yingfan, Wang Hui, Zhu Lie, Jiang Hua
BACKGROUND: Tissue expansion has been widely applied in clinic practice. However, the expanded skin is always insufficient for clinical use and how to promote tissue expansion is still a challenge. Platelet-rich plasma (PRP) contains multiple tissue growth factors and has been widely utilized in hard- and soft-tissue augmentation. However, its feasibility to promote tissue expansion has not been explored. The purpose of this study was to evaluate the possible effect of PRP in tissue expansion...
February 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28161837/autologous-platelet-rich-plasma-prp-in-chronic-penile-lichen-sclerosus-the-impact-on-tissue-repair-and-patient-quality-of-life
#12
Francesco Casabona, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, Ilaria Baldelli
PURPOSE: Lichen sclerosus (LS) is a chronic inflammatory skin condition that frequently involves the anogenital region. Ongoing research is focused on finding more effective treatments for tissue repair and reducing symptoms. The aim of this study is to evaluate the effectiveness of platelet-rich plasma (PRP) local injections in penile LS. METHODS: Forty-five male patients affected by penile LS underwent injections of autologous PRP in the affected skin areas. Age at diagnosis and at first treatment, number of treatments, clinical conditions (phimosis, splitting, inflammation, synechiae, meatus stenosis), symptoms (pain, burning, itching), and functional impairment were considered...
April 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28090513/an-update-and-review-of-cell-based-wound-dressings-and-their-integration-into-clinical-practice
#13
REVIEW
Austin Pourmoussa, Daniel J Gardner, Maxwell B Johnson, Alex K Wong
Chronic wounds affect over 4 million individuals and pose a significant burden to the US healthcare system. Diabetes, venous stasis, radiation or paralysis are common risk factors for chronic wounds. Unfortunately, the current standard of care (SOC) has a high relapse rate and these wounds continue to adversely affect patients' quality of life. Fortunately, advances in tissue engineering have allowed for the development of cell-based wound dressings that promote wound healing by improving cell migration and differentiation...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27975027/use-of-platelet-rich-plasma-for-vulvovaginal-autoimmune-conditions-like-lichen-sclerosus
#14
Fariba Behnia-Willison, Nina Reza Pour, Behrang Mohamadi, Nadia Willison, Madeleine Rock, Ian W Holten, Robert O'Shea, Joseph Miller
BACKGROUND: Lichen sclerosus (LS) is an inflammatory dermatosis with autoimmune pathogenesis. Although relatively common, its true incidence is unknown and likely underestimated. LS is usually anogenital, but in around 10% of patients, it can present as extragenital lesions. Continuous administration of topical corticosteroids is the mainstay of medical treatment. Other treatments are available but are only occasionally prescribed along with or instead of topical steroids. Injection of platelet-rich plasma (PRP) into affected areas has been reported to result in the regeneration of normal skin...
November 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27966263/molecular-and-microarray-based-analysis-of-diversity-among-resting-and-osteogenically-induced-porcine-mesenchymal-stromal-cells-of-several-tissue-origin
#15
Samet Bayraktar, Pascal Jungbluth, René Deenen, Jan Grassmann, Johannes Schneppendahl, Daphne Eschbach, Armin Scholz, Joachim Windolf, Christoph V Suschek, Vera Grotheer
Mesenchymal stromal cells (MSC) play a pivotal role in modern therapeutic approaches in bone healing disorders. Although bone marrow-derived MSC are most frequently used, the knowledge that many other adult tissues represent promising sources for potent MSC has gained acceptance. In the present study, the osteogenic differentiation potential of porcine skin fibroblasts (FB) as well as bone marrow- (BMSC), adipose tissue- (ASC), and dental pulp-derived stromal cells (DSC) were evaluated. However, additional application of BMP-2 significantly elevated the delayed osteogenic differentiation capacity of ASC and FB cultures...
December 14, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27904271/histologic-evidence-of-new-collagen-formulation-using-platelet-rich-plasma-in-skin-rejuvenation-a-prospective-controlled-clinical-study
#16
Ozlem Karabudak Abuaf, Hamza Yildiz, Hüseyin Baloglu, Memet Ersan Bilgili, Hasan Aktug Simsek, Bilal Dogan
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. OBJECTIVE: This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. METHODS: This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27882464/analysis-of-reparative-activity-of-platelet-lysate-effect-on-cell-monolayer-recovery-in-vitro-and-skin-wound-healing-in-vivo
#17
N S Sergeeva, Ya D Shanskii, I K Sviridova, P A Karalkin, V A Kirsanova, S A Akhmedova, A D Kaprin
Platelet lysate prepared from donor platelet concentrate and pooled according to a developed technique stimulates migration of multipotent mesenchymal stromal cells of the human adipose tissue and promotes healing of the monolayer defect in cultures of human fibroblasts and multipotent mesenchymal stromal cells in vitro in concentrations close those of fetal calf serum (5-10%). Lysate of platelets from platelet-rich rat blood plasma stimulated healing of the skin defect by promoting epithelialization and granulation tissue formation...
November 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27863057/platelet-rich-plasma-based-bioactive-membrane-as-a-new-advanced-wound-care-tool
#18
Raffaele Spanò, Anita Muraglia, Maria R Todeschi, Marta Nardini, Paolo Strada, Ranieri Cancedda, Maddalena Mastrogiacomo
Chronic skin ulcers, consequence of diabetes and other pathological conditions, heavily compromise the patients' life quality and represent a high and constantly growing cost for National Health Services. Autologous Platelet Rich Plasma (PRP), has been proposed to treat these lesions. The absence of guidelines for the PRP production and the need of a fresh preparation for each treatment lead us to develop a protocol for the production of an allogenic PRP based bioactive membrane (BAM), standardized for platelet concentration and growth factor release...
November 13, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27827279/plasma-rich-in-growth-factors-promotes-dermal-fibroblast-proliferation-migration-and-biosynthetic-activity
#19
COMPARATIVE STUDY
E Anitua, A Pino, G Orive
OBJECTIVE: The use of plasma rich in growth factors (PRGF) has gained importance in many medical fields due to its regenerative potential. The aim of this study is to evaluate the effects of PRGF on primary skin fibroblasts assessing cell proliferation, migration and secretion of growth factors. The age of the patients from who PRGF was prepared was also studied to determine whether it influenced the outcomes. METHOD: Human dermal fibroblasts were isolated from three healthy volunteers...
November 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27791311/platelets-rich-plasma-versus-minoxidil-5-in-treatment-of-alopecia-areata-a-trichoscopic-evaluation
#20
RANDOMIZED CONTROLLED TRIAL
Moustafa A El Taieb, Hassan Ibrahim, Essam A Nada, Mai Seif Al-Din
Alopecia areata is a common cause of nonscarring alopecia that occurs in a patchy, confluent, or diffuse pattern. Dermoscopy is a noninvasive technique for the clinical diagnosis of many skin diseases. Topical minoxidil solution 5% and platelet rich plasma are important modalities used in treatment of alopecia areata. We aimed to evaluate the efficacy of PRP versus topical minoxidil 5% in the treatment of AA by clinical evaluation and trichoscopic examination. Ninety patients were allocated into three groups; the first was treated with topical minoxidil 5% solution, the second with platelets rich plasma injections, and the third with placebo...
January 2017: Dermatologic Therapy
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