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Platelet rich plasma skin

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https://www.readbyqxmd.com/read/27904271/histologic-evidence-of-new-collagen-formulation-using-platelet-rich-plasma-in-skin-rejuvenation-a-prospective-controlled-clinical-study
#1
Ozlem Karabudak Abuaf, Hamza Yildiz, Hüseyin Baloglu, Memet Ersan Bilgili, Hasan Aktug Simsek, Bilal Dogan
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. OBJECTIVE: This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. METHODS: This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27882464/analysis-of-reparative-activity-of-platelet-lysate-effect-on-cell-monolayer-recovery-in-vitro-and-skin-wound-healing-in-vivo
#2
N S Sergeeva, Ya D Shanskii, I K Sviridova, P A Karalkin, V A Kirsanova, S A Akhmedova, A D Kaprin
Platelet lysate prepared from donor platelet concentrate and pooled according to a developed technique stimulates migration of multipotent mesenchymal stromal cells of the human adipose tissue and promotes healing of the monolayer defect in cultures of human fibroblasts and multipotent mesenchymal stromal cells in vitro in concentrations close those of fetal calf serum (5-10%). Lysate of platelets from platelet-rich rat blood plasma stimulated healing of the skin defect by promoting epithelialization and granulation tissue formation...
November 23, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27863057/platelet-rich-plasma-based-bioactive-membrane-as-a-new-advanced-wound-care-tool
#3
Raffaele Spanò, Anita Muraglia, Maria R Todeschi, Marta Nardini, Paolo Strada, Ranieri Cancedda, Maddalena Mastrogiacomo
Chronic skin ulcers, consequence of diabetes and other pathological conditions, heavily compromise the patients' life quality and represent a high and constantly growing cost for National Health Services. Autologous Platelet Rich Plasma (PRP), has been proposed to treat these lesions. The absence of guidelines for the PRP production and the need of a fresh preparation for each treatment lead us to develop a protocol for the production of an allogenic PRP based bioactive membrane (BAM), standardized for platelet concentration and growth factor release...
November 13, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27827279/plasma-rich-in-growth-factors-promotes-dermal-fibroblast-proliferation-migration-and-biosynthetic-activity
#4
E Anitua, A Pino, G Orive
OBJECTIVE: The use of plasma rich in growth factors (PRGF) has gained importance in many medical fields due to its regenerative potential. The aim of this study is to evaluate the effects of PRGF on primary skin fibroblasts assessing cell proliferation, migration and secretion of growth factors. The age of the patients from who PRGF was prepared was also studied to determine whether it influenced the outcomes. METHOD: Human dermal fibroblasts were isolated from three healthy volunteers...
November 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27791311/platelets-rich-plasma-versus-minoxidil-5-in-treatment-of-alopecia-areata-a-trichoscopic-evaluation
#5
Moustafa A El Taieb, Hassan Ibrahim, Essam A Nada, Mai Seif Al-Din
Alopecia areata is a common cause of nonscarring alopecia that occurs in a patchy, confluent, or diffuse pattern. Dermoscopy is a noninvasive technique for the clinical diagnosis of many skin diseases. Topical minoxidil solution 5% and platelet rich plasma are important modalities used in treatment of alopecia areata. We aimed to evaluate the efficacy of PRP versus topical minoxidil 5% in the treatment of AA by clinical evaluation and trichoscopic examination. Ninety patients were allocated into three groups; the first was treated with topical minoxidil 5% solution, the second with platelets rich plasma injections, and the third with placebo...
October 28, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27778229/production-of-endothelial-progenitor-cells-from-skin-fibroblasts-by-direct-reprogramming-for-clinical-usages
#6
Phuc Van Pham, Ngoc Bich Vu, Thuy Thi-Thanh Dao, Ha Thi-Ngan Le, Lan Thi Phi, Ngoc Kim Phan
Endothelial progenitor cells (EPCs) play an important role in angiogenesis. However, they exist in limited numbers in the human body. This study was aimed to produce EPCs, for autologous transplantation, using direct reprogramming of skin fibroblasts under GMP-compliant conditions. Fibroblasts were collected and cultured from the skin in DMEM/F12 medium supplemented with 5% activated platelet-rich plasma and 1% antibiotic-antimycotic solution. They were then transfected with mRNA ETV2 and incubated in culture medium under hypoxia (5% oxygen) for 14 d...
October 24, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/27761085/outcome-of-intra-operative-injected-platelet-rich-plasma-therapy-during-follicular-unit-extraction-hair-transplant-a-prospective-randomised-study-in-forty-patients
#7
Suruchi Garg
CONTEXT: Platelet-rich plasma (PRP) therapy is finding importance in aesthetic medicine. AIM: The objective of this study was to study efficacy of PRP therapy in follicular unit extraction (FUE) hair transplant. MATERIALS AND METHODS: It is a single-blind, prospective randomised study on 40 FUE hair transplant subjects, allocated in two groups (PRP and non-PRP) alternately. PRP was injected intra-operatively immediately after creating slits over the recipient area in PRP group; and normal saline in non-PRP group...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27677916/biological-therapies-in-regenerative-sports-medicine
#8
Isabel Andia, Nicola Maffulli
Regenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action...
September 28, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27667786/treatment-of-100-chronic-thalassemic-leg-wound-by-plasma-rich-platelets
#9
Hojjat Afradi, Yassaman Saghaei, Zohre A Kachoei, Vahid Babaei, Shahram Teimourian
OBJECTIVE: Thalassemia is a heterogeneous group of congenital hemoglobinopathies caused by mutations in the globin gene complex that result in an unbalanced globin synthesis. Unmatched globin chains bind to the cytosolic surface of red blood cell membrane where they cause oxidative damage that might in part be responsible for membrane weakness. The deformability of red blood cells and hypercoagulable state in thalassemic patients have been incriminated in leg ulcer formation, as this might cause ischemia to the skin and consequently friability and ulceration...
September 26, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27595866/platelet-rich-plasma-and-hyaluronic-acid-an-efficient-biostimulation-method-for-face-rejuvenation
#10
Betul Gozel Ulusal
BACKGROUND: Cosmetic applications of platelet-rich plasma (PRP) are new, and reports are scarce and dispersed in the literature. There are a variety of commercially available kits and injection techniques, and the number and intervals of injections vary. New investigations should focus on developing a standardized procedure for PRP preparation and application methods to augment its efficacy and potency. OBJECTIVES: In this report, we aim to provide data and commentary to assist and add to current guidelines...
September 5, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27555889/easy-to-use-preservation-and-application-of-platelet-rich-plasma-in-combination-wound-therapy-with-a-gelatin-sheet-and-freeze-dried-platelet-rich-plasma-a-case-report
#11
Naoki Morimoto, Natsuko Kakudo, Tsunekata Ogura, Tomoya Hara, Makoto Matsui, Masaya Yamamoto, Yasuhiko Tabata, Kenji Kusumoto
OBJECTIVE: Platelet-rich plasma is blood plasma enriched with platelets and contains various growth factors. Two major issues remain to be resolved in the use of platelet-rich plasma: the short biological activity after application, and the need to prepare platelet-rich plasma at each application instance. To overcome these problems, we developed a drug delivery system using gelatin hydrogel and preserved the excess platelet-rich plasma as freeze-dried platelet-rich plasma. We then applied combination treatment with a gelatin sheet and platelet-rich plasma at the first instance and freeze-dried platelet-rich plasma at the second instance in the treatment of a nonhealing wound...
2016: Eplasty
https://www.readbyqxmd.com/read/27530764/micro-needling-depth-penetration-presence-of-pigment-particles-and-fluorescein-stained-platelets-clinical-usage-for-aesthetic-concerns
#12
Gordon H Sasaki
BACKGROUND: Aesthetic micro-needling (MN) has demonstrated skin permeability to cosmeceutical ingredients and platelet-rich plasma by creating reversible micro-channels in the skin. OBJECTIVES: The purposes of this study were to determine: (1) actual needle depth-penetrations by adjusting needle lengths in a disposable tip of an electric MN device; (2) time-dependent passage of pigment and platelets; and (3) safety and efficacy profiles in patients. METHODS: Excised micro-needled pre-auricular skin was used to determine actual depths of tissue penetration with six needle lengths, and the presence of massaged pigment particles (histological examination) and fluorescein-labeled platelets (confocal laser microscopy) in 1 mm depth micro-channels over an hour...
August 16, 2016: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/27508491/anti-staphylococcal-activity-of-injectable-nano-tigecycline-chitosan-prp-composite-hydrogel-using-drosophila-melanogaster-model-for-infectious-wounds
#13
T R Nimal, Gaurav Baranwal, M C Bavya, Raja Biswas, R Jayakumar
Compared to the current treatment modalities, the use of an injectable hydrogel system, loaded with antibiotic encapsulated nanoparticles for the purpose of treating Staphylococcus aureus (S. aureus) chronic wound infections have several advantages. These include adhesiveness to infection site, reduced frequency of dressings, sustained drug release, inhibition of bacterial growth, and increased healing. In the present work tigecycline nanoparticles were loaded into chitosan-platelet-rich plasma (PRP) hydrogel...
August 31, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27474688/assessment-of-the-efficacy-and-safety-of-single-platelet-rich-plasma-injection-on-different-types-and-grades-of-facial-wrinkles
#14
Naema Y Elnehrawy, Zeinab A Ibrahim, Azza M Eltoukhy, Hala M Nagy
BACKGROUND: Platelet-rich plasma (PRP) is considered as a growing modality for tissue regeneration and a developing research area for clinicians and researchers. PRP injection treatment provides supraphysiological concentrations of growth factors that may help in accelerated tissue remodeling and regeneration. AIM OF THE STUDY: To evaluate the efficacy and safety of single autologous PRP intradermal injection for treatment of facial wrinkles and for facial rejuvenation...
July 29, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27438442/does-platelet-rich-plasma-therapy-increase-pigmentation
#15
Cagri A Uysal, Nilgun Markal Ertas
Platelet-rich plasma (PRP) is an autologous solution of plasma containing 4 to 7 times the baseline concentration of human platelets. Platelet-rich plasma has been widely popular in facial rejuvenation to attenuate wrinkles and has been practically used. The authors have been encountering various patients of increased hiperpigmentation following PRP applications that were performed to attenuate the postinflammatory hiperpigmentation especially after laser treatment. The authors have been using PRP for facial rejuvenation in selected patients and in 1 patient the authors have encountered increased pigmentation over the pigmented skin lesions that were present before the application...
July 19, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27410393/platelet-rich-plasma-bilayered-acellular-matrix-grafting-and-negative-pressure-wound-therapy-in-diabetic-foot-infection
#16
W Deng, J Boey, B Chen, S Byun, E Lew, Z Liang, D G Armstrong
UNLABELLED: Management and treatment of acute severe diabetic foot disease in patients with suboptimal glycaemic control is a critical issue in wound repair. This paper discusses the clinical efficacy of an aggressive surgical intervention combined with targeted use of regenerative medical therapies in limb preservation. Negative pressure wound therapy (NPWT), platelet-rich plasma (PRP), bilayered acellular matrix grafting and split-thickness skin grafting were combined to treat a patient with diabetes, foot necrotising fasciitis and gaseous gangrene...
July 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27394438/platelet-rich-plasma-prp-and-adipose-derived-mesenchymal-stem-cells-stimulatory-effects-on-proliferation-and-migration-of-fibroblasts-and-keratinocytes-in-vitro
#17
Talita Stessuk, Maria Beatriz Puzzi, Elinton Adami Chaim, Paulo César Martins Alves, Erich Vinicius de Paula, Andresa Forte, Juliana Massae Izumizawa, Carolina Caliári Oliveira, Fernando Frei, João Tadeu Ribeiro-Paes
The clinical use of tissue engineering associated with cell therapy is considered a new alternative therapy for the repair of chronic lesions with potential application in different medical areas, mostly in orthopedic and dermatological diseases. Platelet-rich plasma (PRP) is a rich source of growth factors and cytokines important for wound healing. Adipose-derived mesenchymal stem cells (ADSCs) have shown potential to accelerate the resolution of ulcers, to stimulate cell proliferation, and to benefit the quality of skin repair...
September 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27389012/platelet-rich-plasma-stimulates-human-dermal-fibroblast-proliferation-via-a-ras-dependent-extracellular-signal-regulated-kinase-1-2-pathway
#18
Tomoya Hara, Natsuko Kakudo, Naoki Morimoto, Takeshi Ogawa, Fangyuan Lai, Kenji Kusumoto
Platelet-rich plasma (PRP) contains a high concentration of several growth factors and contributes to soft-tissue engineering and wound healing. However, the effect of PRP on human dermal fibroblast proliferation and responses is unknown. This was investigated in the present study using PRP prepared from the whole human blood using the double-spin method. Human dermal fibroblast cultures were established from skin samples collected during plastic surgery. Platelet concentration and growth factor levels in PRP were estimated, and a cell proliferation assay was carried out after PRP treatment...
July 7, 2016: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/27347938/platelet-rich-plasma-loaded-poly-d-l-lactide-poly-ethylene-glycol-poly-d-l-lactide-hydrogel-dressing-promotes-full-thickness-skin-wound-healing-in-a-rodent-model
#19
Manle Qiu, Daoyun Chen, Chaoyong Shen, Ji Shen, Huakun Zhao, Yaohua He
Traditional therapeutic methods for skin wounds have many disadvantages, and new wound dressings that can facilitate the healing process are thus urgently needed. Platelet-rich plasma (PRP) contains multiple growth factors (GFs) and shows a significant capacity to heal soft tissue wounds. However, these GFs have a short half-life and deactivate rapidly; we therefore need a sustained delivery system to overcome this shortcoming. In this study, poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide) (PDLLA-PEG-PDLLA: PLEL) hydrogel was successfully created as delivery vehicle for PRP GFs and was evaluated systematically...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27335599/efficiency-of-carbon-dioxide-fractional-laser-in-skin-resurfacing
#20
Andrej Petrov
AIM: The aim of the study was to confirm the efficiency and safety of the fractional CO2 laser in skin renewal and to check the possibility of having a synergistic effect in patients who besides carbon dioxide laser are treated with PRP (platelet-rich plasma) too. MATERIAL AND METHODS: The first group (Examined Group 1 or EG1) included 107 patients treated with fractional CO2 laser (Lutronic eCO2) as mono-therapy. The second group (Control Group or CG) covered 100 patients treated with neither laser nor plasma in the same period but subjected to local therapy with drugs or other physio-procedures under the existing protocols for treatment of certain diseases...
June 15, 2016: Open Access Macedonian Journal of Medical Sciences
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