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https://www.readbyqxmd.com/read/23024633/pde5-inhibitors-as-potential-tools-in-the-treatment-of-cystic-fibrosis
#1
Sabrina Noel, Barbara Dhooghe, Teresinha Leal
Despite great advances in the understanding of the genetics and pathophysiology of cystic fibrosis (CF), there is still no cure for the disease. Using phosphodiesterase type 5 (PDE5) inhibitors, we and others have provided evidence of rescued F508del-CFTR trafficking and corrected deficient chloride transport activity. Studies using PDE5 inhibitors in mice homozygous for the clinically relevant F508del mutation have been conducted with the aim of restoring F508del-CFTR protein function. We demonstrated, by measuring transepithelial nasal potential difference in F508del mice following intraperitoneal injection of sildenafil, vardenafil, or taladafil at clinical doses are able to restore the decreased CFTR-dependent chloride transport across the nasal mucosa...
2012: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/17911460/therapeutic-challenges-for-systemic-sclerosis-facts-and-future-targets
#2
M Cerinic Matucci, Angela Del Rosso, Perfetto Federico, Riccardo Livi, Ginevra Fiori, Francesca Bartoli, Jelena Blagojevic, Alessio Tempestini, Alberto Pignone
Pulmonary arterial hypertension (PAH) is an important cause of death in systemic sclerosis (SSc), despite the improvement of therapies. An early diagnosis and the use of drugs interfering with the main pathogenic pathways of PAH is pivotal for the improvement of prognosis in primary PAH and PAH secondary to autoimmune rheumatic diseases, mainly SSc. Lately, new specific therapies have been developed targeting prostacyclin, endothelin, and nitric oxide pathways, the major pathogenic pathways leading to endothelial dysfunction in PAH...
September 2007: Annals of the New York Academy of Sciences
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