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D Caillaud, P Chanez, R Escamilla, P-R Burgel, I Court-Fortune, P Nesme-Meyer, G Deslee, T Perez, J-L Paillasseur, C Pinet, G Jebrak, N Roche
BACKGROUND: Some studies suggest that asthma-COPD overlap syndrome (ACOS) is associated with worse outcomes than chronic obstructive pulmonary disease (COPD). The goal of this study was to further explore the clinical characteristics and survival of patients with ACOS identified in a real-life cohort of patients with COPD. METHODS: Data from the French COPD cohort 'INITIATIVES BronchoPneumopathie Chronique Obstructive' (n = 998 patients) were analyzed to assess the frequency of ACOS defined as a physician diagnosis of asthma before the age of 40 years and to analyze its impact...
January 2017: Allergy
Pier Luigi Temporelli
The epidemiology of chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are well known. Each of these conditions has an important impact on quality of life and functional status and on healthcare consumption. Through shared risk factors and pathophysiological mechanisms CHF and COPD coexist more frequently than expected from the respective populations observed by the pulmonologist or cardiologist. This has important prognostic and therapeutic implications. Several registry-based studies and post-hoc analyses of large randomized controlled trials evaluating COPD as a comorbidity in CHF outpatients have highlighted the negative prognostic impact of the comorbidity in terms of constraint in use of recommended treatments...
2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Alex Crawley, Tessa Laubscher, Patricia Muddiman, Lynette Kosar
No abstract text is available yet for this article.
May 2016: Canadian Family Physician Médecin de Famille Canadien
M Mekki, N B Mefteh, A Sayhi, N Ridene, M Mtaoua, E Rbia, N B Kahla, A Khelil
OBJECTIFS: La dyspnée est un motif de recours et d'admission fréquent aux urgences. Le type de la dyspnée, son mode de survenue, ses facteurs déclenchant, son caractère (inspiratoire, expiratoire) sont des éléments importants de l'interrogatoire. MéTHODES: Il s'agit d'une étude rétrospective, menée au SAU de l'Hôpital Maamouri de Nabeul, durant une année, incluant tout patient se présentant pour une dyspnée. Celle post-traumatique n'a pas été retenue dans notre série...
December 2015: Annales de Cardiologie et D'angéiologie
Thierry Perez, Pierre Régis Burgel, Jean-Louis Paillasseur, Denis Caillaud, Gaetan Deslée, Pascal Chanez, Nicolas Roche
BACKGROUND: Assessment of dyspnea in COPD patients relies in clinical practice on the modified Medical Research Council (mMRC) scale, whereas the Baseline Dyspnea Index (BDI) is mainly used in clinical trials. Little is known on the correspondence between the two methods. METHODS: Cross-sectional analysis was carried out on data from the French COPD cohort Initiatives BPCO. Dyspnea was assessed by the mMRC scale and the BDI. Spirometry, plethysmography, Hospital Anxiety-Depression Scale, St George's Respiratory Questionnaire, exacerbation rates, and physician-diagnosed comorbidities were obtained...
2015: International Journal of Chronic Obstructive Pulmonary Disease
F Salvati, M Signora, G Cardillo
The Authors fully share cricitisms voiced in international literature to NSCLC longsurvivors, in particular those remarkes related to advanced disease patients following various anti-tumor treatments ( mostly multimodal). To this point, even the NCCN version 3.2014 guidelines prove inadequate as they mostly focus on longsurvivors post-NSCLC early stage surgical resection. Although AIOM Working Group's recommendations for follow-up seem to be more adequate, still they lack depth with respect to advanced-stage bronchogenic carcinoma...
2015: La Clinica Terapeutica
F Lemoigne, E Barré, M Arsento, F Bily, G Gibelin, M Pelser, J-L Paillasseur, J Garcia-Macé, T Perez, N Roche
INTRODUCTION: This study evaluated a standardized procedure aiming at early detection of COPD in a consecutive population of employees visiting occupational medicine. METHODS: A total of 2818 employees were included by 22 occupational physicians in 5 centers. Respiratory symptoms, smoking status, occupational exposures and socioprofessional categories were collected. Subjects with at least one symptom and/or risk factor underwent spirometry. RESULTS: In this population aged 39±12 years, 2603 patients were free of known asthma or COPD...
January 2015: Revue des Maladies Respiratoires
Stefano Nardini, Gaetano Cicchitto, Fernando De Benedetto, Claudio F Donner, Mario Polverino, Claudio M Sanguinetti, Alberto Visconti
BACKGROUND: Non communicable chronic diseases (including respiratory ones) are the leading cause of death and disability. To cope with them we need to redesign the health system, improving primary prevention, screening, and outpatient services, while fully integrating different branches of the health service. The Italian Ministry of Health published extended guidelines on integrated COPD management (COPD-GL) in 2010. In2011 a condensed version was produced. These documents define appropriateness of management regarding both the specialist and the health service...
2014: Multidisciplinary Respiratory Medicine
Christophe Marti, Olivier Grosgurin, Nicolas Beysard, Fabrice Dami, Pierre-Nicolas Carron, Olivier Rutschmann
New evidences published this year are susceptible to change the management of several medical emergencies. Combined antiplatelet therapy might be beneficial for the management of TIA or minor stroke and rapid blood pressure lowering might improve the outcome in patients with intracerebral hemorrhage. A restrictive red cell transfusion strategy is indicated in case of upper digestive bleeding and coagulation factors concentrates are superior to fresh frozen plasma for urgent warfarin reversal. Prolonged systemic steroid therapy is not warranted in case of acute exacerbation of BPCO, and iterative physiotherapy is not beneficial after acute whiplash...
January 15, 2014: Revue Médicale Suisse
Nicolas Roche, Gaetan Deslée, Denis Caillaud, Graziella Brinchault, Isabelle Court-Fortune, Pascale Nesme-Meyer, Pascale Surpas, Roger Escamilla, Thierry Perez, Pascal Chanez, Christophe Pinet, Gilles Jebrak, Jean-Louis Paillasseur, Pierre-Régis Burgel
Reports regarding gender-related differences in COPD expression have provided conflicting results. In the French Initiatives BPCO real-world cohort, which contained 688 patients (146 women) when data were extracted, women were matched with men (1:3 ratio: n = 107:275) on age (5-year intervals) and FEV1 (5% predicted intervals) and comparisons were performed using univariate logistic regressions. For a given age and level of airflow obstruction, women with COPD had higher BOD scores due to more pronounced dyspnea and lower BMI, suggesting worse prognosis, and were more likely to exhibit anxiety, suggesting the need for specific assessment and care...
2014: Respiratory Research
Denis Caillaud, Pascal Chanez, Roger Escamilla, Pierre-Régis Burgel, Isabelle Court-Fortune, Pascale Nesme-Meyer, Gaëtan Deslee, Thierry Perez, Christophe Pinet, Nicolas Roche
BACKGROUND AND OBJECTIVE: Previous studies suggested that chronic nasal symptoms (CNS) are frequent in chronic obstructive pulmonary disease (COPD) subjects, but their contribution to dyspnoea and quality-of-life (QoL) impairment is not clearly established. METHODS: Data from the French COPD cohort 'Initiatives bronchopneumopathie chronique obstructive' were analyzed to assess the frequency of CNS (rhinorrhea, obstruction, anosmia) in COPD patients and analyze their impact and associated risk factors...
April 2014: Respirology: Official Journal of the Asian Pacific Society of Respirology
Domenico Loffredo, Alberto Marvaso, Sandro Ceraso, Nicola Cinelli, Aldo Rocca, Mario Vitale, Michele Rossi, Eugenio Genovese, Bruno Amato, Mariapia Cinelli
BACKGROUND: Liver represents the main organ subject to metastases from colorectal tumors. Resections of liver metastases from colorectal cancer have a well-considered therapeutic role underlined by survival of 5 years by approximately 50-60% of surgical cases as is deduced from an analysis of the most recent literature. The objective of surgery is to eradicate the metastases present and obtain a margin free from neoplastic impact of amplitude of approximately 1 cm with residual liver quantity at the end of the intervention that allows the patient to survive...
2013: BMC Surgery
Claudio Iannarone, Fabrizio Sacco, Marco Micozzi, Alessandra Fegiz, Silvia Fiorelli, Vincenza Vendittelli, Giovanni Pinto
Central venous catheter techniques find at present use for administering of NPT, for the drug injection ( especially chemiotherapeutic drugs) because of the possible damage of a few substances when perfused in a peripheral way. At present port-a-cath find their most extensive use: these are systems which can be set up and tolerated for many months. For the access to subclavian vein must be necessary put in supine decubitus, with light Trendelenburg position, with the opposite arm along the body and the head turned on the opposite side...
2012: Annali Italiani di Chirurgia
Pierre-Régis Burgel, Roger Escamilla, Thierry Perez, Philippe Carré, Denis Caillaud, Pascal Chanez, Christophe Pinet, Gilles Jebrak, Graziella Brinchault, Isabelle Court-Fortune, Jean-Louis Paillasseur, Nicolas Roche
BACKGROUND: Comorbidities are frequent in subjects with COPD, but their contribution to health-related quality of life (HRQoL) impairment is not clearly established. METHODS: Cross-sectional analysis of data from the French COPD cohort Initiatives BPCO. Data were recorded in stable state and included spirometry, dyspnea (modified Medical Research Council - mMRC-scale), mood disorders (hospital anxiety-depression scale) and physician-diagnosed comorbidities including diabetes, hypertension, coronary artery disease, chronic heart failure, venous thromboembolism...
February 2013: Respiratory Medicine
N Roche, B Aguilaniu, P-R Burgel, I Durand-Zaleski, D Dusser, R Escamilla, T Perez, C Raherison, T Similowski
INTRODUCTION: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a cause of suffering for patients and a burden for healthcare systems and society. Their prevention represents individual and collective challenge. The present article is based on the work of a group of experts who met on 5th and 6th May 2011 and seeks to highlight the importance of AECOPD. STATE OF THE ART: In the absence of easily quantifiable criteria, the definition of AECOPD varies in the literature, making identification difficult and affecting interpretation of study results...
June 2012: Revue des Maladies Respiratoires
Denis Caillaud, Franck Lemoigne, Philippe Carré, Roger Escamilla, Pascal Chanez, Pierre-Régis Burgel, Isabelle Court-Fortune, Gilles Jebrak, Christophe Pinet, Thierry Perez, Graziella Brinchault, Jean-Louis Paillasseur, Nicolas Roche
BACKGROUND: The contribution of occupational exposures to COPD and their interaction with cigarette smoking on clinical pattern of COPD remain underappreciated. The aim of this study was to explore the contribution of occupational exposures on clinical pattern of COPD. METHODS: Cross-sectional data from a multicenter tertiary care cohort of 591 smokers or ex-smokers with COPD (median FEV1 49%) were analyzed. Self-reported exposure to vapor, dust, gas or fumes (VDGF) at any time during the entire career was recorded...
2012: BMC Public Health
P Leghissa, M Santini, C Bancone, G Deleidi, R Valsecchi, G Mosconi
The purpose of this study is to analyse the various risk factors present in the artisan and semi industrial bread making technological cycle as well as verify the kind of illnesses and ailments encountered amongst the workforce. The objective being to identify a preventive action programme together with the necessary Health support measures. Our case study, drew upon a sample of 428 workers (252 bread makers and 176 sales staff). Each of them was asked to complete a questionnaire about the production process, the kind of exposure to wheat flour particles, smoking habits, present or past common allergy pathologies, the symptoms connected to the work, both in the allergic and osteomuscular field...
January 2011: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
G Jebrak
INTRODUCTION: COPD management guidelines have been proposed to improve the major outcomes for COPD patients. In clinical practice, COPD treatment is only partially consistent with current guidelines and recommendations. OBJECTIVE: Global initiative for chronic obstructive lung disease (GOLD) guidelines are based on a COPD severity scale and are subject to change as the evidence based evolves. The main purpose of our study was to access whether the treatments prescribed to patients with COPD were consistent with these guidelines...
2010: Revue des Maladies Respiratoires
P-R Burgel, J-L Paillasseur, D Caillaud, I Tillie-Leblond, P Chanez, R Escamilla, I Court-Fortune, T Perez, P Carré, N Roche
Classification of chronic obstructive pulmonary disease (COPD) is usually based on the severity of airflow limitation, which may not reflect phenotypic heterogeneity. Here, we sought to identify COPD phenotypes using multiple clinical variables. COPD subjects recruited in a French multicentre cohort were characterised using a standardised process. Principal component analysis (PCA) was performed using eight variables selected for their relevance to COPD: age, cumulative smoking, forced expiratory volume in 1 s (FEV(1)) (% predicted), body mass index, exacerbations, dyspnoea (modified Medical Research Council scale), health status (St George's Respiratory Questionnaire) and depressive symptoms (hospital anxiety and depression scale)...
September 2010: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
S A Beye, O Kane, T N Tchikangoua, A Ndiaye, P A Dieng, G Ciss, P S Ba, M Ndiaye
The aim of this study was to evaluate the anaesthetic assumption of responsibility of the surgery of the aneurism of under renal abdominal aorta. It was a retrospective study over two years (April 2005 - April 2007). Seven patients were operated, the mean age was 69,4 years. An operational pre evaluation was carried out among all patients including/understanding an interrogation, a clinical examination and a clinical assessment. All the patients profited from a general anaesthesia with controlled ventilation...
2009: Le Mali Médical
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