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Pierre-Régis Burgel, Jean-Louis Paillasseur, Wim Janssens, Jacques Piquet, Gerben Ter Riet, Judith Garcia-Aymerich, Borja Cosio, Per Bakke, Milo A Puhan, Arnulf Langhammer, Inmaculada Alfageme, Pere Almagro, Julio Ancochea, Bartolome R Celli, Ciro Casanova, Juan P de-Torres, Marc Decramer, Andrés Echazarreta, Cristobal Esteban, Rosa Mar Gomez Punter, MeiLan K Han, Ane Johannessen, Bernhard Kaiser, Bernd Lamprecht, Peter Lange, Linda Leivseth, Jose M Marin, Francis Martin, Pablo Martinez-Camblor, Marc Miravitlles, Toru Oga, Ana Sofia Ramírez, Don D Sin, Patricia Sobradillo, Juan J Soler-Cataluña, Alice M Turner, Francisco Javier Verdu Rivera, Joan B Soriano, Nicolas Roche
This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses.Data from 2409 COPD patients of French/Belgian COPD cohorts were analysed using cluster analysis resulting in the identification of subgroups, for which clinical relevance was determined by comparing 3-year all-cause mortality. Classification and regression trees (CARTs) were used to develop an algorithm for allocating patients to these subgroups...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Maeva Zysman, Gaëtan Deslee, Denis Caillaud, Pascal Chanez, Roger Escamilla, Isabelle Court-Fortune, Pascale Nesme-Meyer, Thierry Perez, Jean-Louis Paillasseur, Christophe Pinet, Gilles Jebrak, Nicolas Roche, Pierre-Régis Burgel
In patients with COPD, there is controversy regarding the association of blood eosinophil (Eos) levels with 1) exacerbation frequency and 2) the effect of inhaled corticosteroids for prevention of exacerbations. To determine whether Eos define subgroups of patients exhibiting attributes of COPD clinical phenotypes, we compared clinical features and mortality rates in COPD patients from the Initiatives BPCO French cohort categorized using different thresholds of blood Eos levels. The following data were collected at inclusion: medical and smoking history, occupational exposures, dyspnea, cough and sputum production, exacerbations in the previous year, history of allergy and asthma, nasal symptoms, body mass index, St George Respiratory Questionnaire (SGRQ) total score, post-bronchodilator spirometry, comorbidities, and medications...
2017: International Journal of Chronic Obstructive Pulmonary Disease
G Jébrak, P-R Burgel, D Caillaud, G Deslée, G Brinchault, P Chanez, I Court-Fortune, R Escamilla, P Nesme-Meyer, C Pinet, T Perez, J-L Paillasseur, N Roche
INTRODUCTION: We studied the pattern changes over time of medication prescriptions for COPD and their conformity with French and international recommendations using data from patients in the prospective French cohort "Initiatives BPCO". METHOD: Eight hundred and forty-six patients have been included during a first period from August, 2001 till May 2006 (n=425) and a second period from June, 2006 till June, 2012 (n=421). The pivotal date was based on the tiotropium availability in France...
May 2017: Revue des Maladies Respiratoires
G W Canonica, F Blasi, N Scichilone, L Simoni, A Zullo, C Giovannetti, C Briguglio, S Barsanti, R Antonelli Incalzi
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. The symptoms of COPD are troublesome, variable, can occur during all parts of the 24-h day and have a substantial impact on patients' health status, quality of life and healthcare resource utilization. Reducing symptoms, improving health status and increasing physical activity are major goals in the management of stable COPD. In order to provide effective, patient-oriented care, patients should be evaluated on the basis of lung function, frequency of symptoms and patient-perceived impact of symptoms on their lives and treatment decisions made on a case-by-case basis...
May 30, 2017: European Journal of Internal Medicine
O Galera, G Grimal, D Bajon, Y Darolles
INTRODUCTION: In spite of recommendations of the highest level of proof (rank A), the respiratory rehabilitation remains very widely sub-prescribed by general practitioners, who are nevertheless in the front line in the care and the follow-up of the patients affected by BPCO. MATERIAL AND METHODS: Semi-qualitative study with the general practitioners installed in the city of Montauban (Tarn-et-Garonne). RESULTS: The rate of answer was 57%...
April 18, 2017: Revue de Pneumologie Clinique
D Caillaud, P Chanez, R Escamilla, P-R Burgel, I Court-Fortune, P Nesme-Meyer, G Deslee, T Perez, J-L Paillasseur, C Pinet, G Jebrak, N Roche
BACKGROUND: Some studies suggest that asthma-COPD overlap syndrome (ACOS) is associated with worse outcomes than chronic obstructive pulmonary disease (COPD). The goal of this study was to further explore the clinical characteristics and survival of patients with ACOS identified in a real-life cohort of patients with COPD. METHODS: Data from the French COPD cohort 'INITIATIVES BronchoPneumopathie Chronique Obstructive' (n = 998 patients) were analyzed to assess the frequency of ACOS defined as a physician diagnosis of asthma before the age of 40 years and to analyze its impact...
January 2017: Allergy
Pier Luigi Temporelli
The epidemiology of chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are well known. Each of these conditions has an important impact on quality of life and functional status and on healthcare consumption. Through shared risk factors and pathophysiological mechanisms CHF and COPD coexist more frequently than expected from the respective populations observed by the pulmonologist or cardiologist. This has important prognostic and therapeutic implications. Several registry-based studies and post-hoc analyses of large randomized controlled trials evaluating COPD as a comorbidity in CHF outpatients have highlighted the negative prognostic impact of the comorbidity in terms of constraint in use of recommended treatments...
2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Alex Crawley, Tessa Laubscher, Patricia Muddiman, Lynette Kosar
No abstract text is available yet for this article.
May 2016: Canadian Family Physician Médecin de Famille Canadien
M Mekki, N B Mefteh, A Sayhi, N Ridene, M Mtaoua, E Rbia, N B Kahla, A Khelil
OBJECTIFS: La dyspnée est un motif de recours et d'admission fréquent aux urgences. Le type de la dyspnée, son mode de survenue, ses facteurs déclenchant, son caractère (inspiratoire, expiratoire) sont des éléments importants de l'interrogatoire. MéTHODES: Il s'agit d'une étude rétrospective, menée au SAU de l'Hôpital Maamouri de Nabeul, durant une année, incluant tout patient se présentant pour une dyspnée. Celle post-traumatique n'a pas été retenue dans notre série...
December 2015: Annales de Cardiologie et D'angéiologie
Thierry Perez, Pierre Régis Burgel, Jean-Louis Paillasseur, Denis Caillaud, Gaetan Deslée, Pascal Chanez, Nicolas Roche
BACKGROUND: Assessment of dyspnea in COPD patients relies in clinical practice on the modified Medical Research Council (mMRC) scale, whereas the Baseline Dyspnea Index (BDI) is mainly used in clinical trials. Little is known on the correspondence between the two methods. METHODS: Cross-sectional analysis was carried out on data from the French COPD cohort Initiatives BPCO. Dyspnea was assessed by the mMRC scale and the BDI. Spirometry, plethysmography, Hospital Anxiety-Depression Scale, St George's Respiratory Questionnaire, exacerbation rates, and physician-diagnosed comorbidities were obtained...
2015: International Journal of Chronic Obstructive Pulmonary Disease
F Salvati, M Signora, G Cardillo
The Authors fully share cricitisms voiced in international literature to NSCLC longsurvivors, in particular those remarkes related to advanced disease patients following various anti-tumor treatments ( mostly multimodal). To this point, even the NCCN version 3.2014 guidelines prove inadequate as they mostly focus on longsurvivors post-NSCLC early stage surgical resection. Although AIOM Working Group's recommendations for follow-up seem to be more adequate, still they lack depth with respect to advanced-stage bronchogenic carcinoma...
2015: La Clinica Terapeutica
F Lemoigne, E Barré, M Arsento, F Bily, G Gibelin, M Pelser, J-L Paillasseur, J Garcia-Macé, T Perez, N Roche
INTRODUCTION: This study evaluated a standardized procedure aiming at early detection of COPD in a consecutive population of employees visiting occupational medicine. METHODS: A total of 2818 employees were included by 22 occupational physicians in 5 centers. Respiratory symptoms, smoking status, occupational exposures and socioprofessional categories were collected. Subjects with at least one symptom and/or risk factor underwent spirometry. RESULTS: In this population aged 39±12 years, 2603 patients were free of known asthma or COPD...
January 2015: Revue des Maladies Respiratoires
Stefano Nardini, Gaetano Cicchitto, Fernando De Benedetto, Claudio F Donner, Mario Polverino, Claudio M Sanguinetti, Alberto Visconti
BACKGROUND: Non communicable chronic diseases (including respiratory ones) are the leading cause of death and disability. To cope with them we need to redesign the health system, improving primary prevention, screening, and outpatient services, while fully integrating different branches of the health service. The Italian Ministry of Health published extended guidelines on integrated COPD management (COPD-GL) in 2010. In2011 a condensed version was produced. These documents define appropriateness of management regarding both the specialist and the health service...
2014: Multidisciplinary Respiratory Medicine
Christophe Marti, Olivier Grosgurin, Nicolas Beysard, Fabrice Dami, Pierre-Nicolas Carron, Olivier Rutschmann
New evidences published this year are susceptible to change the management of several medical emergencies. Combined antiplatelet therapy might be beneficial for the management of TIA or minor stroke and rapid blood pressure lowering might improve the outcome in patients with intracerebral hemorrhage. A restrictive red cell transfusion strategy is indicated in case of upper digestive bleeding and coagulation factors concentrates are superior to fresh frozen plasma for urgent warfarin reversal. Prolonged systemic steroid therapy is not warranted in case of acute exacerbation of BPCO, and iterative physiotherapy is not beneficial after acute whiplash...
January 15, 2014: Revue Médicale Suisse
Nicolas Roche, Gaetan Deslée, Denis Caillaud, Graziella Brinchault, Isabelle Court-Fortune, Pascale Nesme-Meyer, Pascale Surpas, Roger Escamilla, Thierry Perez, Pascal Chanez, Christophe Pinet, Gilles Jebrak, Jean-Louis Paillasseur, Pierre-Régis Burgel
Reports regarding gender-related differences in COPD expression have provided conflicting results. In the French Initiatives BPCO real-world cohort, which contained 688 patients (146 women) when data were extracted, women were matched with men (1:3 ratio: n = 107:275) on age (5-year intervals) and FEV1 (5% predicted intervals) and comparisons were performed using univariate logistic regressions. For a given age and level of airflow obstruction, women with COPD had higher BOD scores due to more pronounced dyspnea and lower BMI, suggesting worse prognosis, and were more likely to exhibit anxiety, suggesting the need for specific assessment and care...
2014: Respiratory Research
Denis Caillaud, Pascal Chanez, Roger Escamilla, Pierre-Régis Burgel, Isabelle Court-Fortune, Pascale Nesme-Meyer, Gaëtan Deslee, Thierry Perez, Christophe Pinet, Nicolas Roche
BACKGROUND AND OBJECTIVE: Previous studies suggested that chronic nasal symptoms (CNS) are frequent in chronic obstructive pulmonary disease (COPD) subjects, but their contribution to dyspnoea and quality-of-life (QoL) impairment is not clearly established. METHODS: Data from the French COPD cohort 'Initiatives bronchopneumopathie chronique obstructive' were analyzed to assess the frequency of CNS (rhinorrhea, obstruction, anosmia) in COPD patients and analyze their impact and associated risk factors...
April 2014: Respirology: Official Journal of the Asian Pacific Society of Respirology
Domenico Loffredo, Alberto Marvaso, Sandro Ceraso, Nicola Cinelli, Aldo Rocca, Mario Vitale, Michele Rossi, Eugenio Genovese, Bruno Amato, Mariapia Cinelli
BACKGROUND: Liver represents the main organ subject to metastases from colorectal tumors. Resections of liver metastases from colorectal cancer have a well-considered therapeutic role underlined by survival of 5 years by approximately 50-60% of surgical cases as is deduced from an analysis of the most recent literature. The objective of surgery is to eradicate the metastases present and obtain a margin free from neoplastic impact of amplitude of approximately 1 cm with residual liver quantity at the end of the intervention that allows the patient to survive...
2013: BMC Surgery
Claudio Iannarone, Fabrizio Sacco, Marco Micozzi, Alessandra Fegiz, Silvia Fiorelli, Vincenza Vendittelli, Giovanni Pinto
Central venous catheter techniques find at present use for administering of NPT, for the drug injection ( especially chemiotherapeutic drugs) because of the possible damage of a few substances when perfused in a peripheral way. At present port-a-cath find their most extensive use: these are systems which can be set up and tolerated for many months. For the access to subclavian vein must be necessary put in supine decubitus, with light Trendelenburg position, with the opposite arm along the body and the head turned on the opposite side...
2012: Annali Italiani di Chirurgia
Pierre-Régis Burgel, Roger Escamilla, Thierry Perez, Philippe Carré, Denis Caillaud, Pascal Chanez, Christophe Pinet, Gilles Jebrak, Graziella Brinchault, Isabelle Court-Fortune, Jean-Louis Paillasseur, Nicolas Roche
BACKGROUND: Comorbidities are frequent in subjects with COPD, but their contribution to health-related quality of life (HRQoL) impairment is not clearly established. METHODS: Cross-sectional analysis of data from the French COPD cohort Initiatives BPCO. Data were recorded in stable state and included spirometry, dyspnea (modified Medical Research Council - mMRC-scale), mood disorders (hospital anxiety-depression scale) and physician-diagnosed comorbidities including diabetes, hypertension, coronary artery disease, chronic heart failure, venous thromboembolism...
February 2013: Respiratory Medicine
N Roche, B Aguilaniu, P-R Burgel, I Durand-Zaleski, D Dusser, R Escamilla, T Perez, C Raherison, T Similowski
INTRODUCTION: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a cause of suffering for patients and a burden for healthcare systems and society. Their prevention represents individual and collective challenge. The present article is based on the work of a group of experts who met on 5th and 6th May 2011 and seeks to highlight the importance of AECOPD. STATE OF THE ART: In the absence of easily quantifiable criteria, the definition of AECOPD varies in the literature, making identification difficult and affecting interpretation of study results...
June 2012: Revue des Maladies Respiratoires
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